ELEVENTH WORLD CONFERENCE ON THE FUTURE OF SCIENCE Venice, Fondazione Giorgio Cini - September 17, 18, 19, 2015

Precision Medicine: Present Challenges for Future Cures

The future of medicine is being increasingly articulated around the notion of precision, with the promise of therapies that target no longer the general or average identity of diseases but rather their concrete and singular unfolding in individuals, a promise that has already been fulfilled in a few brilliant cases.

Importantly, it is not only therapies that are being reframed around the goal of greater precision. From diagnosis to prevention all the way to the very fabric of health care systems, the entire edifice of medicine, in its complex ramifications through our rapidly changing societies, is being challenged by the growing ambition to the precision and, sometimes, the personalization of cure and care, meant in their widest sense.

It is as much a molecular as a societal frontier, whereby the increasingly molecular and digital gaze of biomedicine meets the equally forceful digitalization of our social life, generating that intimate intertwining between “big data biology” and “big data society” that acts as a defining feature of our future-oriented present. For the 11th edition of our Future of Science Conference, leading experts across multiple disciplines will confront for the first time the various paths ahead towards precision medicine and the best ways to tread them as conscious citizens.

For information and registration [email protected] - www.thefutureofscience.org

Conference Commitees

 President - Umberto Veronesi  Vice President - Kathleen Kennedy Townsend  Secretary General - Chiara Tonelli  Organizing Commitee - Carlo Bucci, Pasquale Gagliardi, Armando Peres, Lucio Pinto, Monica Ramaioli, Giada Tronchetti Provera  Scientific Commitee - Zhores Alferov, Peter Atkins, J.Michael Bishop, Claudio Bordignon, Claude Cohen-Tannoudji, Daniel Dennett, Luc Montagnier, Paul Nurse, Philip Pettit, Carlo Rubbia  Program Commitee – Maria Ines Colnaghi, Delia Colombo, Fulvio Luccini, Michela Matteoli, Emanuele Montanari, Pier Giuseppe Pelicci, Telmo Pievani, Emilio Quintè, Carlo Alberto Redi, Giuseppe Testa, Lisa Vozza.

The Conference is organized by:

update July 24, 2015

Thursday – September 17, 2015 – h. 5.00/7.00 p.m.

WELCOME ADDRESSES

Umberto Veronesi President The Future of Science

Giovanni Bazoli President Giorgio Cini Foundation

Marco Tronchetti Provera President Silvio Tronchetti Provera Foundation

Kathleen Kennedy Townsend Vice President The Future of Science

Chiara Tonelli Secretary General The Future of Science

OPENING LECTURES Precisely Now: the Time to Giuseppe Professor of Molecular Biology, University of Shape Precision Medicine Testa Milan; Director, Laboratory of Stem Cell Across Cure and Care Epigenetics, European Institute of Oncology

Airc Lecture Precision medicine: How to Joseph Professor of Neurological Surgery, Chair in exploit the growing knowledge Costello Molecular Neuro-Oncology, University of on the evolving genomes of cells California, San Francisco to improve cancer prevention and therapy

CONFERENCE SESSIONS Friday - September 18, 2015 – h. 9.00/18.00 p.m.

Digitizing the Environment: Pier Giuseppe Professor of Pathology, University of Milan; Epigenomic Medicine and the Pelicci Director, Department of Experimental Oncology, Environmental Impact on European Institute of Oncology Health and Disease In Good Company: Our Julie Segre Senior Investigator, Microbial Genomics Section Microbial Ecosystem in Health National Human Genome Research Institute, NIH and Disease Cyber-Physical Systems for Alberto The Buttner Chair, Department of Electrical Medical Data Collection and Sangiovanni- Engineering and Computer Sciences, University of Analysis Vincentelli California at Berkeley Big Data meets Big Science and Edward Dove Global Alliance for Genomics and Health; Big Ethics: Emerging Trends, University of Edinburgh, School of Law Regulatory Challenges and Opportunities for Engagement Is so-called clinical Big Data Alexander Professor of Microbiology, Director Institute for actually sufficient? Hoffman Quantitative and Computational Biosciences, University of California, Los Angeles (UCLA)

Local biologies in the age of Margaret Lock Professor Emerita, Department of Social precision medicine Studies of Medicine and Department of Anthropology, McGill University Bioelectronic Medicine Kris Famm Head of Bioelectronics R&D unit at GSK – GlaxoSmithKline, UK Gender-specific medicine: a Giovannella Baggio Full Professor, Chair of Gender Medicine, task for the third Department of Molecular Medicine, millennium University of Padua Druggable Future: What it Guido Guidi Head Pharma Region Europe, Novartis Takes and How We Can Get There Round Table - Giovannella Full Professor, Chair of Gender Medicine, Department Baggio of Molecular Medicine, University of Padua Getting personal: societal, Professor of Regenerative Medicine, University of Milan political and ethical - Giulio Cossu and The University of Manchester challenges of precision medicine - Carlo Alberto Member of the Accademia dei Lincei; Professor of Developmental Biology, Department of Biology and Redi Biotechnology, University of Pavia

- Giuseppe Testa Professor of Molecular Biology, University of Milan; Director, Laboratory of Stem Cell Epigenetics, European Institute of Oncology

Saturday - September 19, 2015 – h. 9.00/13.00 p.m.

Nuclear transfer: genetic Carlo Alberto Redi Nuclear transfer: genetic reprogramming and reprogramming and cloning cloning Regenerative medicine today: Giulio Cossu Professor of Regenerative Medicine, University achievements, hopes and hypes of Milan and The University of Manchester The Formation of Future Doctors Gianluca Vago Rector, University of Milan

Access to health care – political Walter General Director, Directorate General for aspects Bergamaschi Health, Regione Lombardia Emergent epidemiological Francesco Longo Professor, Department of Policy Analysis and trends and new organizational Public Management and SDA/CERGAS Bocconi modes for Health Care Systems University

Organising Secretariat Fondazione Umberto Veronesi, +39 02 76018187 [email protected] www.thefutureofscience.org