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RANDY SCHEKMAN Department of Molecular and Cell Biology, Howard Hughes Medical Institute, University of California, Berkeley, USA
GENES AND PROTEINS THAT CONTROL THE SECRETORY PATHWAY Nobel Lecture, 7 December 2013 by RANDY SCHEKMAN Department of Molecular and Cell Biology, Howard Hughes Medical Institute, University of California, Berkeley, USA. Introduction George Palade shared the 1974 Nobel Prize with Albert Claude and Christian de Duve for their pioneering work in the characterization of organelles interrelated by the process of secretion in mammalian cells and tissues. These three scholars established the modern field of cell biology and the tools of cell fractionation and thin section transmission electron microscopy. It was Palade’s genius in particular that revealed the organization of the secretory pathway. He discovered the ribosome and showed that it was poised on the surface of the endoplasmic reticulum (ER) where it engaged in the vectorial translocation of newly synthesized secretory polypeptides (1). And in a most elegant and technically challenging investigation, his group employed radioactive amino acids in a pulse-chase regimen to show by autoradiograpic exposure of thin sections on a photographic emulsion that secretory proteins progress in sequence from the ER through the Golgi apparatus into secretory granules, which then discharge their cargo by membrane fusion at the cell surface (1). He documented the role of vesicles as carriers of cargo between compartments and he formulated the hypothesis that membranes template their own production rather than form by a process of de novo biogenesis (1). As a university student I was ignorant of the important developments in cell biology; however, I learned of Palade’s work during my first year of graduate school in the Stanford biochemistry department. -
Broadcast and on Demand Bulletin Issue Number 299 22/02/16
Ofcom Broadcast and On Demand Bulletin Issue number 299 22 February 2016 1 Ofcom Broadcast and On Demand Bulletin, Issue 299 22 February 2016 Contents Introduction 3 Broadcast Standards cases In Breach Azmat-e-Islam Peace TV Urdu, 12 and 13 September 2015, 14:00 5 Derren Brown: Something Wicked This Way Comes Watch, 6 December 2015, 09:10 13 Jessie Disney Channel, 23 October 2015, 15:55 16 Geo News Geo News, 28 October 2015, 16:00 22 Big Tunes Brit Asia TV, 30 September 2015, 09:30 29 Trend ATN Bangla UK, 22 June 2015, 10:00 31 Resolved Geoff Lloyd with Annabel Port Absolute Radio, 14 January 2016, 18:40 35 Broadcast Licence Conditions cases In Breach Retention and production of recordings 1 Ummah FM (Reading), 12 to 14 November 2015 38 Tables of cases Investigations Not in Breach 40 Complaints assessed, not investigated 41 Complaints outside of remit 49 Investigations List 51 2 Ofcom Broadcast and On Demand Bulletin, Issue 299 22 February 2016 Introduction Under the Communications Act 2003 (“the Act”), Ofcom has a duty to set standards for broadcast content as appear to it best calculated to secure the standards objectives1. Ofcom also has a duty to secure that every provider of a notifiable On Demand Programme Services (“ODPS”) complies with certain standards requirements as set out in the Act2. Ofcom must include these standards in a code, codes or rules. These are listed below. The Broadcast and On Demand Bulletin reports on the outcome of investigations into alleged breaches of those Ofcom codes and rules below, as well as licence conditions with which broadcasters regulated by Ofcom are required to comply. -
Pan Macmillan AUTUMN CATALOGUE 2021 PUBLICITY CONTACTS
Pan Macmillan AUTUMN CATALOGUE 2021 PUBLICITY CONTACTS General enquiries [email protected] Alice Dewing FREELANCE [email protected] Anna Pallai Amy Canavan [email protected] [email protected] Caitlin Allen Camilla Elworthy [email protected] [email protected] Elinor Fewster Emma Bravo [email protected] [email protected] Emma Draude Gabriela Quattromini [email protected] [email protected] Emma Harrow Grace Harrison [email protected] [email protected] Jacqui Graham Hannah Corbett [email protected] [email protected] Jamie-Lee Nardone Hope Ndaba [email protected] [email protected] Laura Sherlock Jess Duffy [email protected] [email protected] Ruth Cairns Kate Green [email protected] [email protected] Philippa McEwan [email protected] Rosie Wilson [email protected] Siobhan Slattery [email protected] CONTENTS MACMILLAN PAN MANTLE TOR PICADOR MACMILLAN COLLECTOR’S LIBRARY BLUEBIRD ONE BOAT MACMILLAN Nine Lives Danielle Steel Nine Lives is a powerful love story by the world’s favourite storyteller, Danielle Steel. Nine Lives is a thought-provoking story of lost love and new beginnings, by the number one bestseller Danielle Steel. After a carefree childhood, Maggie Kelly came of age in the shadow of grief. Her father, a pilot, died when she was nine. Maggie saw her mother struggle to put their lives back together. As the family moved from one city to the next, her mother warned her about daredevil men and to avoid risk at all cost. Following her mother’s advice, and forgoing the magic of first love with a high-school boyfriend who she thought too wild, Maggie married a good, dependable man. -
Five Great Ideas of Biology
GREATGREAT IDEASIDEAS OFOF BIOLOGYBIOLOGY Paul Nurse KITP Public Lecture, Feb 24, 2010 THETHE CELLCELL The basic unit of life ROBERTROBERT HOOKEHOOKE’’SS MICROSCOPEMICROSCOPE Cork Image: Past Present STEMSTEM IMAGES:IMAGES: PASTPAST ANDAND PRESENTPRESENT Nehemiah Grew (1682) ANTONIANTONI VANVAN LEEUWENHOEKLEEUWENHOEK MICROORGANISMSMICROORGANISMS VANVAN LEEUWENHOEK?LEEUWENHOEK? THEODORTHEODOR SCHWANNSCHWANN “We have seen that all organisms are composed of essentially like parts, namely, of cells.” (1839) RUDOLFRUDOLF VIRCHOWVIRCHOW “Every animal appears as a sum of vital units, each of which bears in itself the complete characteristics of life.” (1858) CELLCELL Rockefeller Nobel Prize Winners in Cell Biology George E. Palade (1974) Christian de Duve (1974) Albert Claude (1974) Günter Blobel (1999) MAMMALIANMAMMALIAN EMBRYOEMBRYO SPERMSPERM ANDAND EGGEGG THETHE CELLCELL The basic unit of life Underpins all reproduction and development Stem cells THETHE GENEGENE Basis of heredity GREGORGREGOR MENDELMENDEL MENDELMENDEL’’SS GARDENGARDEN PEASPEAS PEASPEAS 1919TH CENTURYCENTURY CHROMOSOMESCHROMOSOMES EDOUARDEDOUARD VANVAN BENEDENBENEDEN’’SS NEMATODENEMATODE CHROMOSOMESCHROMOSOMES PNEUMOCOCCUSPNEUMOCOCCUS Avery, MacLeod and McCarty, Rockefeller University (1944) DNADNA MOLECULEMOLECULE CENTRALCENTRAL DOGMADOGMA THETHE GENEGENE Basis of heredity Genotype to phenotype Implications for what we are EVOLUTIONEVOLUTION BYBY NATURALNATURAL SELECTIONSELECTION Life evolves Mechanism of natural selection ERASMUSERASMUS ANDAND CHARLESCHARLES DARWINDARWIN -
Medical Students in England and France, 1815-1858
FLORENT PALLUAULT D.E.A., archiviste paléographe MEDICAL STUDENTS IN ENGLAND AND FRANCE 1815-1858 A COMPARATIVE STUDY University of Oxford Faculty of Modern History - History of Science Thesis submitted for the degree of Doctor in Philosophy Trinity 2003 ACKNOWLEDGMENTS In the first instance, my most sincere gratitude goes to Dr Ruth Harris and Dr Margaret Pelling who have supervised this thesis. Despite my slow progress, they have supported my efforts and believed in my capacities to carry out this comparative study. I hope that, despite its defects, it will prove worthy of their trust. I would like to thank Louella Vaughan for providing an interesting eighteenth-century perspective on English medical education, sharing her ideas on my subject and removing some of my misconceptions. Similarly, I thank Christelle Rabier for her support and for our discussions regarding her forthcoming thesis on surgery in England and France. My thanks naturally go to the staff of the various establishments in which my research has taken me, and particularly to the librarians at the Wellcome Library for the History and Understanding of Medicine in London, the librarians in the History of Science Room at the Bibliothèque nationale de France in Paris, and to Bernadette Molitor and Henry Ferreira-Lopes at the Bibliothèque Inter-Universitaire de Médecine in Paris. I am grateful to Patricia Gillet from the Association d’entraide des Anciens élèves de l’École des Chartes for the financial support that the Association has given me and to Wes Cordeau at Texas Supreme Mortgage, Inc. for the scholarship that his company awarded me. -
Wtd021996.Pdf
The Case of the MolectlEar Mowetnap: The structure and function of serpins 3 The rerpinr are highly eifenive pmteaie inhibitm. tenaciously gnpping their pmtcin target So ruccerrful is thc leipin mecha- nism that an emodinanly diverie range of adaptations has evolved. In some rerpinr inhibitoiy act~ilyis anwaled by par- timlii ligands. In some ofthe rerpini' more disant mlatber. inhtbtoiy artivly has been lost altogether and eherfunnronr gained. II in the homone ciden thymxine- and cortiro. stemid.binding globulini. Serpinr aie partiwlady important in the conml ofpmteoiflic carcadeder in the blood ansthmmbin inhibits blood clotting. CI-inhibitor c~nmlsmmplement anbation. and the inappm- pnately named SI-antitiypGn inhibits the elartare releasedby inflammatoiy leukocltei. Abnomalitiei of plarma rerpini are iurptisingiy common. and cause a vatiefy of direares - mainly of the dmilation.Ai many as one in a loo0 people har an amnhmm. bin abnomab, and ths a predspmiuon 10 thmmbosiit. The best-studiedabnormal sepini are ~mamofol-anti. Wdn. Some IO per cent of Eumpeam <anyone oftwo mylationi (5 or 7.) that mwlt in a mild (S) or severe (2) plaima deficiency ofthe Inhibitor. About I ~n2wO Eumpeanr caqE combination alvanant genes (ZZ or Si),reeruhing ins severe al-antilvprin deficiencF inhib&totorleveliare imulciem to pmten the elarric tissue ofthe lungs. leading to the dennrc- Dve disease emphysema in adulthood. Although Z antnn>rin is wtheiized in homqgoter. it is ineiütiently secreted. Innead. 4 discovered this daes appearto happen: Z sntwrin rerdiiy A SHARED PATHOLOGY pobmerized imo bng fibnh. whale hepatmfie indw~nswere The of ihe explanation for this shared molemlar pathology recently Gas L@: found to conrirl of emangkdanutvpYin fibnb became apparent when &IIthe known piaims repin mutations The physiological and The modelcould also explain the rapidly pmgreirive liver cir- were plotted an the 1hree.dimenrionaIlemplate nmum rhe~(n8nfancy. -
Descendants of Thomas Hodgkin
Descendants of Thomas Hodgkin Charles E. G. Pease Pennyghael Isle of Mull Descendants of Thomas Hodgkin 1-Thomas Hodgkin died on 29 Jul 1709. Thomas married Ann Alcock on 21 May 1665. Ann died on 24 Apr 1689. They had three children: Thomas, John, and Elizabeth. Noted events in their marriage were: • They had a residence in Shutford, Banbury, Oxfordshire. 2-Thomas Hodgkin was born on 29 Mar 1666 in Shutford, Banbury, Oxfordshire and died in 1740 at age 74. Thomas married Elizabeth. They had seven children: Ann, Thomas, John, Mary, Elizabeth, Hannah, and Richard. 3-Ann Hodgkin was born on 24 Dec 1696. Ann married _____ Hall. 3-Thomas Hodgkin was born on 7 Aug 1699 and died on 6 Feb 1752 in Penn's Neck, New Jersey. USA at age 52. General Notes: Emigrated to Pennsylvania. 3-John Hodgkin was born on 31 Oct 1701 in Shipston on Stour, Warwickshire and died on 9 Oct 1786 at age 84. Noted events in his life were: • Miscellaneous: Until 1931, Shipston on Stour was part of Worcestershire. John married Susanna Hitchman. They had three children: John, Susanna, and Thomas. 4-John Hodgkin1 was born on 25 May 1741, died on 31 May 1815 in Shipston on Stour, Warwickshire at age 74, and was buried on 4 Jun 1815. Noted events in his life were: • He worked as a Woolstapler in Shipston on Stour, Warwickshire. John married Elizabeth Gibbs1 on 28 Feb 1765. Elizabeth died on 29 Apr 1805. They had five children: John, Susanna, Mary, Elizabeth, and Anna. 5-John Hodgkin1,2,3 was born on 11 Feb 1766 in Shipston on Stour, Warwickshire and died on 29 Sep 1845 in Tottenham, London at age 79. -
Innate Immunity and Dendritic Cells in Kidney Disease and the Nobel Prize
EDITORIALS www.jasn.org Innate Immunity and Dendritic nately, Janeway died in 2003 and was no longer eligible to receive the prize. Cells in Kidney Disease and the The discoveries of Hoffmann and Janeway alerted immu- nologists all over the world to the possibility of a new signal- Nobel Prize ing pathway, and in 1998, Bruce Beutler and colleagues at the † Howard Hughes Medical Institute in Dallas first identified Hans-Joachim Anders* and Christian Kurts TLR4 as recognizing bacterial endotoxin.5 Beutler’s approach *Medizinische Poliklinik, Klinikum der Universita¨t Mu¨ nchen-LMU, Campus Innenstadt, Munich, Germany; and †Institutes of Molecu- was as clever as simple. He took advantage of two well-known lar Medicine and Experimental Immunology (IMMEI), University lipopolysaccharide-resistant mouse strains to map the newly Clinic of Bonn, Bonn, Germany discovered loci of the Toll genes. In doing so, he realized that J Am Soc Nephrol 22: ●●●–●●●, 2011. endotoxin resistance was linked to loss-of-function muta- doi: 10.1681/ASN.2011100975 tions in the Tlr4 gene. Two more circumstances encouraged researchers from many disciplines to rush into this new area of science, pro- On December 10, 2011, the Nobel Prize for Physiology or ducing more than 18,000 related publications within the last Medicine will honor the work of Jules Hoffmann, Bruce 15 years: first, Tlr4 mutant mice as well as suitable immuno- Beutler, and Ralph Steinman for their landmark discoveries stimulatory compounds, now discovered as agonists for dis- in the field of immunology. This recognition brings wide at- tinct TLRs, became available at relatively low costs to every- tention to a paradigm shift in understanding how multicel- one, and second, Shizou Akira, in Osaka, produced null mice lular organisms sense and interpret their external and inter- for most TLRs and many other related genes, and did not nal environments in maintaining homeostasis or initiating hesitate to share them with collaborators and competitors. -
April 28 Sir Paul Nurse
MONDAY, APRIL 26th 8 pm We look forward to welcoming to Kenton SIR PAUL NURSE RATHER THAN GIVE A TALK, WE ARE VERY FORTUNATE IN THAT SIR PAUL IS HAPPY TO ANSWER QUESTIONS ON HIS EXTENSIVE CAREER AND HOBBIES PLEASE HAVE YOUR QUESTIONS READY OR SEND THEM IN BEFORE THE MEETING Paul Nurse is a geneticist and cell biologist who has worked on how the eukaryotic cell cycle is controlled. His major work has been on the cyclin dependent protein kinases and how they regulate cell reproduction. He is Director of the Francis Crick Institute in London, and has served as President of the Royal Society, Chief Executive of Cancer Research UK and President of Rockefeller University. He shared the 2001 Nobel Prize in Physiology or Medicine and has received the Albert Lasker Award, the Gairdner Award, the Louis Jeantet Prize and the Royal Society's Royal and Copley Medals. He was knighted by The Queen in 1999, received the Legion d'honneur in 2003 from France, and the Order of the Rising Sun in 2018 from Japan. He served for 15 years on the Council of Science and Technology, advising the Prime Minister and Cabinet, and is presently a Chief Scientific Advisor for the European Union. As well as his many medical accomplishments, amazingly Paul also has time to fly planes and engage in varied hobbies Paul flies gliders and vintage aeroplanes and has been a qualified bush pilot. He also likes the theatre, hill-walking, going to museums and art galleries, and running very slowly. All our Zoom sessions are available on the Kenton https://us02web.zoom.us/j/3531782577? YouTube channel: pwd=N0tlSWxxUGZmOEUrM1ZzclJFN1pzdz09 Kenton Shul In The Park Goes Live. -
Nobel Laureates
The Rockefeller University » Nobel Laureates Sunday, December 15, 2013 Calendar Directory Employment DONATE AWARDS & HONORS University Overview & Nobel Laureates Quick Facts History Since the institution's founding in 1901, 24 Nobel Prize winners have been associated with the university. Of these, two Faculty Awards are Rockefeller graduates (Edelman and Baltimore) and six laureates are current members of the Rockefeller faculty (Günter Blobel, Christian de Duve, Paul Greengard, Roderick MacKinnon, Paul Nurse and Torsten Wiesel). Nobel Prize Albert Lasker Awards Ralph M. Roderick Paul Nurse National Medal of Science Steinman MacKinnon 2001 Institute of Medicine 2011 2003 Physiology or National Academy of Physiology or Chemistry Medicine Sciences Medicine Gairdner Foundation International Award Campus Map & Views Travel Directions Paul Günter R. Bruce NYC Resources Greengard Blobel Merrifield Office of the President 2000 1999 1984 Physiology or Physiology or Chemistry Chief of Staff Medicine Medicine Board of Trustees and Corporate Officers Sustainability Torsten N. David Albert Contact Wiesel Baltimore Claude 1981 1975 1974 Physiology or Physiology or Physiology or Medicine Medicine Medicine Christian George E. Stanford de Duve Palade Moore 1974 1974 1972 Physiology or Physiology or Chemistry Medicine Medicine William H. Gerald M. H. Keffer Stein Edelman Hartline 1972 1972 1967 Chemistry Physiology or Physiology or Medicine Medicine Peyton Joshua Edward L. Rous Lederberg Tatum 1966 1958 1958 http://www.rockefeller.edu/about/awards/nobel/[2013/12/16 7:42:49] The Rockefeller University » Nobel Laureates Physiology or Physiology or Physiology or Medicine Medicine Medicine Fritz A. John H. Wendell Lipmann Northrop M. Stanley 1953 1946 1946 Physiology or Chemistry Chemistry Medicine Herbert S. -
All Living Organisms Are Organised Into Large Groups Called Kingdoms. Fungi Were Orig
What are fungi and how important are they? All living organisms are organised into large groups called Kingdoms. Fungi were originally placed in the Plant Kingdom then, scientists learned that fungi were more closely related to animals than to plants. Then scientists decided that fungi were not sufficiently similar to animals to be placed in the animal kingdom and so today fungi have their own Kingdom – the Fungal Kingdom. There are thought to be around up to 3.8 million species of fungi, of which only 120,000 have been named. The fungal kingdom is largely hidden from our view and we usually only see the “fruit” of a fungus. The living body of a fungus is called a mycelium and is made up of a branching network of filaments known as hyphae. Fungal mycelia are usually hidden in a food source like wood and we only know they are there when they develop mushrooms or other fruiting bodies. Some fungi only produce microscopic fruiting bodies and we never notice them. Fungi feed by absorbing nutrients from the organic material that they live in. They digest their food before they absorb it by secreting acids and enzymes. Different fungi have evolved to live on various types of organic matter, some live on plants (Magneportha grisea – the rice blast fungus), some on animals (Trichophyton rubrum - the athlete’s foot fungus) and some even live on insects (Cordyceps australis). Helpful fungi Most of us use fungi every day without even knowing it. We eat mushrooms and Quorn, but we also prepare many other foods using fungi. -
ILAE Historical Wall02.Indd 10 6/12/09 12:04:44 PM
2000–2009 2001 2002 2003 2005 2006 2007 2008 Tim Hunt Robert Horvitz Sir Peter Mansfi eld Barry Marshall Craig Mello Oliver Smithies Luc Montagnier 2000 2000 2001 2002 2004 2005 2007 2008 Arvid Carlsson Eric Kandel Sir Paul Nurse John Sulston Richard Axel Robin Warren Mario Capecchi Harald zur Hauser Nobel Prizes 2000000 2001001 2002002 2003003 200404 2006006 2007007 2008008 Paul Greengard Leland Hartwell Sydney Brenner Paul Lauterbur Linda Buck Andrew Fire Sir Martin Evans Françoise Barré-Sinoussi in Medicine and Physiology 2000 1st Congress of the Latin American Region – in Santiago 2005 ILAE archives moved to Zurich to become publicly available 2000 Zonismide licensed for epilepsy in the US and indexed 2001 Epilepsia changes publishers – to Blackwell 2005 26th International Epilepsy Congress – 2001 Epilepsia introduces on–line submission and reviewing in Paris with 5060 delegates 2001 24th International Epilepsy Congress – in Buenos Aires 2005 Bangladesh, China, Costa Rica, Cyprus, Kazakhstan, Nicaragua, Pakistan, 2001 Launch of phase 2 of the Global Campaign Against Epilepsy Singapore and the United Arab Emirates join the ILAE in Geneva 2005 Epilepsy Atlas published under the auspices of the Global 2001 Albania, Armenia, Arzerbaijan, Estonia, Honduras, Jamaica, Campaign Against Epilepsy Kyrgyzstan, Iraq, Lebanon, Malta, Malaysia, Nepal , Paraguay, Philippines, Qatar, Senegal, Syria, South Korea and Zimbabwe 2006 1st regional vice–president is elected – from the Asian and join the ILAE, making a total of 81 chapters Oceanian Region