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THE 2018 LASKER MEDICAL RESEARCH AWARDS

Nomination Packet albert and mary lasker foundation

November 1, 2017

Greetings:

On behalf of the Albert and Mary Lasker Foundation, I invite you to submit a nomination for the 2018 Lasker Medical Research Awards.

Since 1945, the Lasker Awards have recognized the contributions of , physicians, and public citizens who have made major advances in the understanding, diagnosis, treatment, cure, and prevention of disease.

The Medical Research Awards will be offered in three categories in 2018: Basic Research, Clinical Research, and Special Achievement.

The Lasker Foundation seeks nominations of outstanding scientists; nominations of women and minorities are encouraged.

Nominations that have been made in previous years are not automatically reconsidered. Please see the Nomination Requirements section of this booklet for instructions on updating and resubmitting a nomination.

The Foundation accepts electronic submissions. For information on submitting an electronic nomination, please visit www.laskerfoundation.org.

Lasker Awards often presage future recognition of the Nobel committee, and they have become known popularly as “America’s Nobels.” Eighty-seven Lasker laureates have received the , including 40 in the last three decades. Additional information on the Awards Program and on Lasker laureates can be found on our website, www.laskerfoundation.org.

A distinguished panel of jurors will select the scientists to be honored with Lasker Medical Research Awards. The 2018 Awards will be presented at a luncheon ceremony given by the Foundation in City on Friday, September 21, 2018.

Sincerely,

Joseph L. Goldstein, M. D. Chair Lasker Medical Research Awards Jury

405 Lexington Avenue 32nd Floor New York, NY 10174 tel 212-286-0222 www.laskerfoundation.org THE 2018 LASKER MEDICAL RESEARCH Purpose and Description of the Awards AWARDS The purpose of these Awards is to honor individuals who have made significant contributions in basic or clinical research in diseases that are the main cause of death and disability. The Award winners may reside in any country of the world. ALBERT LASKER BASIC MEDICAL RESEARCH AWARD A list of previous recipients of the Lasker Awards in Basic Medical Research, Clinical Medical Research, and Special For a fundamental discovery that opens up Achievement in Medical is included at the end a new area of biomedical science. of this booklet.

LASKER~DEBAKEY CLINICAL MEDICAL Each Award consists of an honorarium, a citation and an RESEARCH AWARD inscribed statuette of the Winged Victory of Samothrace,

For a major advance that improves the lives symbolizing victory over death and disease. of many thousands of people. When the Award is given to more than one individual in a category, the honorarium will be divided among the LASKER~KOSHLAND SPECIAL ACHIEVEMENT winners, and each will receive a statuette and a citation. AWARD IN MEDICAL SCIENCE More than one may be nominated if they have

For research accomplishments and scientific worked as a team, or if they independently have made statesmanship that engender the deepest comparable contributions in their field. No more than feelings of awe and respect. three individuals will be considered for an Award in the Basic or Clinical category.

The Jurors’ evaluations of the contributions of the nomi- nees depend heavily on the information supplied in the nomination forms. Therefore, the nomination should be accurate, detailed, current and complete. Supporting letters that specifically address the nominee’s scientific accomplishments will be helpful to the Jury. Nomination Requirements

1. No more than three individuals will be considered 3. All nominations must include the following for an Award in the Basic or Clinical category. additional information: Nominators for the Basic or Clinical Award should a. A brief one-page biography including major provide the following: awards received by each nominee. a. A short citation (30 words or less) that highlights b. A one-page list of six (6) peer reviewed journal the nominee(s)’s research worthy of a . references that substantiate the statements made b. A concise summary (150 words or less) of the in your nomination. Do NOT submit reprints. nominee(s)’s scientific contributions to this research. 4. No more than five (5) letters of support per c. A description of how the nominee(s)’s work nomination will be accepted. Letters in support of represents a major advance in either basic or clinical Basic nominations should address the of the sciences and how his or her original contributions nominee(s)’s discoveries, and how those discoveries led to this advance. (Limit response to 2 pages or less). have opened up a new area of biomedical science. d. A list of other scientist(s), in addition to your Letters in support of Clinical nominations should nominee(s), who should be considered for this address uniquely innovative contributions of the award, and why. Please Note: The Jury considers nominee(s) that have advanced patient care for this question a crucial one, and nominations many thousands of people. Letters of support can without a complete response will be returned. be either included in the nomination package or (Limit response to 1 page or less). mailed separately.

2. Special Achievement Awards are intended to honor 5. Previous nominations and support letters are not a single individual. Nominators for the Special automatically carried forward. If you wish to Achievement Award should provide the following: re-nominate a previous candidate, please update a. A short citation (30 words or less) that highlights the earlier nomination and resubmit it by completing the nominee’s career in research worthy of this a 2018 nomination form. The 2018 nomination Special Achievement Award. should contain all pertinent previously submitted material, including updated letters of support and b. A description of the outstanding achievements any significant new developments. of the individual and the reasons why he or she is deserving of Lasker recognition. (Limit response 6. Nominations and all supporting materials must to 2 pages or less). be received by the Foundation no later than February 5, 2 0 1 8.

Submitting a Nomination

Email your completed nomination packet, Please note: along with supporting materials As an alternative to completing this nomination (PDF or Word documents), to packet, you may securely submit an online [email protected] nomination and all supporting materials. It is not necessary to send printed materials. To do so, please visit www.laskerfoundation.org However, if you prefer to submit a nomination by mail or courier, send to:

Lasker Medical Research Awards : David Keegan 405 Lexington Avenue, 32nd Floor New York, NY 10174 2018 LASKER MEDICAL RESEARCH AWARDS

Please check the appropriate Award.

BASIC MEDICAL RESEARCH AWARD (no more than 3 nominees)

CLINICAL MEDICAL RESEARCH AWARD (no more than 3 nominees)

SPECIAL ACHIEVEMENT AWARD IN MEDICAL SCIENCE (1 nominee only)

Nominee NAME

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ORGANIZATION NAME AND ADDRESS

TELEPHONE FAX E-MAIL

Nominee NAME

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ORGANIZATION NAME AND ADDRESS

TELEPHONE FAX E-MAIL

Nominee NAME

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ORGANIZATION NAME AND ADDRESS

TELEPHONE FAX E-MAIL

Nominator NAME

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ORGANIZATION NAME AND ADDRESS

TELEPHONE FAX E-MAIL NOMINEES’ NAME

NOMINATION FOR BASIC MEDICAL RESEARCH AWARD OR CLINICAL MEDICAL RESEARCH AWARD

Suggested citation for nominee(s)’s award (30 words or less).

For example: “For the discovery of ...” or “For the development of ...” or “For the pioneering studies of ...”

Summary of nominee(s)’s scientific contributions (150 words or less). NOMINEES’ NAME

NOMINATION FOR BASIC MEDICAL RESEARCH AWARD OR CLINICAL MEDICAL RESEARCH AWARD

1. Why does the nominee(s)’s work represent a major advance in either the basic or clinical sciences and what are his or her original contributions that led to this advance?

LIMIT RESPONSE TO NO MORE THAN 2 PAGES NOMINEES’ NAME NOMINEES’ NAME

NOMINATION FOR BASIC MEDICAL RESEARCH AWARD OR CLINICAL MEDICAL RESEARCH AWARD

2. List other scientist(s), in addition to your nominee(s), who should be considered for this award, and why. Please Note: The Jury considers this question a crucial one, and nominations without a complete response will be returned.

LIMIT RESPONSE TO THIS PAGE NOMINEE’S NAME

NOMINATION FOR SPECIAL ACHIEVEMENT IN MEDICAL SCIENCE AWARD

Suggested citation for nominee(s)’s award (30 words or less).

For example: “For the discovery of ...” or “For the development of ...” or “For the pioneering studies of ...”

Highlight the outstanding achievements of the individual whom you are nominating as well as the reason why he or she is deserving of recognition from the Lasker Foundation.

LIMIT RESPONSE TO THIS AND THE NEXT PAGE NOMINEE’S NAME THE LASKER AWARDS 1946 – 2017

Basic Research 2003 1987 1974 Awards Robert G. Roeder Ludwik Gross Howard E. Skipper 2002 Sol Spiegelman 2017 * James E. Rothman Howard M. Temin Michael N. Hall * * Randy W. Schekman * 1986 1971 2016 Rita Levi-Montalcini * 2001 William G. Kaelin, Jr. Stanley Cohen * Peter J. Ratcliffe * * Martin J. Evans 1985 Gregg L. Semenza * Michael S. Brown * * 1970 2015 Joseph L. Goldstein * 2000 Stephen J. Elledge Earl W. Sutherland * 1984 Evelyn M. Witkin Aaron Ciechanover * * Michael Potter 1969 2014 Georges J. F. Köhler * Bruce Merrifield * César Milstein * 1999 1968 Clay M. Armstrong 1983 Marshall W. Nirenberg * 2013 Bertil Hille Eric R. Kandel * H. Gobind Khorana * Richard H. Scheller Roderick MacKinnon * Vernon B. Mountcastle William F. Windle Thomas C. Südhof * 1998 1982 1967 2012 Lee Hartwell * J. Michael Bishop * Bernard B. Brodie Michael Sheetz Yoshio Masui Raymond L. Erikson 1966 * Hidesaburo Hanafusa Harold E. Varmus * George E. Palade * 1997 Robert C. Gallo 1965 2011 Mark S. Ptashne Franz-Ulrich Hartl 1981 Robert W. Holley * Arthur L. Horwich 1996 Barbara McClintock * 1964 Robert F. Furchgott * 2010 * 1980 * Douglas Coleman * Harry Rubin Jeffrey M. Friedman 1995 Herbert W. Boyer 1963 Peter C. Doherty Stanley N. Cohen * Lyman C. Craig 2009 Jack L. Strominger A. Dale Kaiser Emil R. Unanue * 1962 Don C. Wiley 1979 * Choh H. Li Rolf M. Zinkernagel Walter Gilbert * 2008 * * 1960 Victor R. Ambros 1994 * M.H.F. Wilkins David C. Baulcombe Stanley B. Prusiner * * Gary B. Ruvkum 1978 F.H.C. Crick * 1993 Hans W. Kosterlitz James D. Watson * 2007 Günter Blobel * John Hughes James V. Neel Ralph M. Steinman * Solomon H. Snyder L.S. Penrose 1991 Ernest Ruska * 2006 Edward B. Lewis * 1977 James Hillier Elizabeth H. Blackburn Christiane Nüsslein-Volhard K. Sune D. Bergström * * * 1959 Carol W. Greider * Bengt Samuelsson * Albert Coons Jack W. Szostak * 1989 John R. Vane * Michael J. Berridge Jules Freund 2005 Alfred G. Gilman 1976 * 1958 Ernest A. McCulloch Edwin G. Krebs Rosalyn S. Yalow * * Peyton Rous James E. Till * 1975 2004 Alfred D. Hershey 1988 Roger C. L. Guillemin * * Gerhard Schramm Pierre Chambon Thomas R. Cech Andrew V. Schally * * Heinz Fraenkel-Conrat Ronald M. Evans Phillip A. Sharp Frank J. Dixon * Irvine H. Page Elwood V. Jensen Henry G. Kunkel

* DENOTES NOBEL PRIZE WINNER ** NOBEL LAUREATE PRIOR TO LASKER AWARD 1957 2013 1995 1973 Isaac Starr Graeme M. Clark Barry J. Marshall * Paul M. Zoll Ingeborg Hochmair William B. Kouwenhoven 1956 Blake S. Wilson 1994 Karl Meyer John Allen Clements 1972 Francis O. Schmitt 2012 Min Chiu Li Roy Calne 1993 Roy Hertz 1955 Thomas E.Starzl Donald Metcalf Denis Burkitt Karl Paul Link Joseph H. Burchenal Carl J. Wiggers 2011 1991 V. Anomah Ngu Youyou * John L. Ziegler 1954 Edmund Klein Edwin B. Astwood 2010 1989 Emil Frei III John F. Enders * Etienne-Emile Baulieu Emil J. Freireich Albert Szent-Gyorgyi James F. Holland ** 2009 1988 Donald Pinkel 1953 Brian J. Druker Vincent P. Dole Paul P. Carbone Hans A. Krebs Nicholas B. Lydon Vincent T. DeVita, Jr. * 1987 Charles L. Sawyers Eugene J. Van Scott Mogens Schou Isaac Djerassi * 2008 C. Gordon Zubrod 1986 1952 Akira Endo Myron Essex F. 1971 * 2007 Robert C. Gallo Edward D. Freis 1951 Alain Carpentier * Karl F. Meyer Albert Starr 1970 1985 Robert A. Good 1950 2006 Bernard Fisher Aaron T. Beck George Wells Beadle 1969 * 1984 George C. Cotzias 2005 1949 Paul C. Lauterbur * Alec Jeffries André Cournand 1968 * Edwin M. Southern 1983 William S. Tillett John H. Gibbon, Jr. F. Mason Sones, Jr. L.R. Christensen 2004 1967 1982 1948 Charles D. Kelman Robert Allan Phillips Roscoe O. Brady Vincent du Vigneaud * 2003 Elizabeth F. Neufeld 1966 Selman A. Waksman * René J. Dubos Sidney Farber Ravinder N. Maini 1981 Louis Sokoloff 1947 1965 2002 Oswald T. Avery Albert B. Sabin Willem J. Kolff 1980 Homer Smith Belding H. Scribner Cyril A. Clarke 1964 Ronald Finn 1946 Nathan S. Kline 2001 Vincent J. Freda Carl Ferdinand Cori * Robert G. Edwards * John G. Gorman 1963 William Pollack Michael E. DeBakey 2000 Charles Huggins Harvey J. Alter 1978 * Clinical Research Michael Houghton Michael Heidelberger 1962 Awards Robert Austrian Joseph E. Smadel 1999 Emil C. Gotschlich David W. Cushman 1960 2017 Miguel A. Ondetti 1977 Karl Paul Link Douglas R. Lowy Inge G. Edler Irving S. Wright John T. Schiller 1998 C. Hellmuth Hertz Edgar V. Allen Alfred J. Knudson, Jr. 2016 Peter C. Nowell 1976 1959 Ralf F.W. Bartenschlager Janet D. Rowley Raymond P. Ahlquist John Holmes Dingle Charles M. Rice J. W. Black Gilbert Dalldorf Michael J. Sofia 1997 * Robert E. Gross Alfred Sommer 1975 2015 Godfrey N. Hounsfield 1958 James P. Allison 1996 * William Oldendorf Robert W. Wilkins Porter Warren Anderson, Jr. 2014 David H. Smith 1974 John B. Robbins John Charnley Mahlon R. DeLong Rachel Schneerson

* DENOTES NOBEL PRIZE WINNER ** NOBEL LAUREATE PRIOR TO LASKER AWARD ** *

NOBEL LAUREATEPRIOR TOLASKER AWARD DENOTES NOBEL PRIZE WINNER Philip Levine S. Wiener Alexander John Friend Mahoney 1946 Thomas Francis, Jr. 1947 Philip S. Hench Edward C. Kendall Max Theiler 1949 George Papanicolaou 1950 Frederic A. Gibbs William G. Lennox Catherine Macfarlane L’EsperanceElise 1951 H. TrendleyDean Frederick S. McKay Conrad A. Elvehjem 1952 Dudley White Paul 1953 Robert E. Gross B.Helen Taussig Alfred Blalock 1954 Carl Muschenheim Walsh McDermott SelikoffIrving Edward H. Robitzek L. VarcoRichard E. WardenHerbert Morley Cohen C. WaltonLillehei 1955 PatzArnall V. Everett Kinsey Jonas E. Salk Louis N. Katz 1956 Richard E. Shope Heinz E. Lehmann Pierre Deniker Henri Laborit Robert H. Noce Nathan S. Kline Jal VakilRustom 1957

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** * Sydney Brenner 2000 James Jr. E. Darnell. 2002 2004 Joseph G. Gall 2006 2008 J. WeatherallDavid 2010 Tom Maniatis Donald D. Brown 2012 Mary-Claire King 2014 Bruce M. Alberts 2016 Special Achievement Michael R. Bloomberg 2009 National Institutes of Clinical Center of the 2011 Melinda Gates 2013 Médecins Sans Frontières 2015 Planned Parenthood 2017 Awards Public Service Maclyn McCarty 1994 Paul C. Zamecnik 1996 A. McKusickVictor 1997 Daniel E. Koshland, Jr. 1998 Seymour S. Kety 1999 in Medical Science

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Lister Hill 1968 Warren Magnuson 1973 Jules Stein 1975 World Health Organization 1976 Theodore Cooper L. RichardsonElliot 1978 John Wilson 1979 Saul Krugman Maurice R. Hilleman 1983 Henry J. Heimlich 1984 Ann Landers (Eppie Lederer) Lane W.Adams 1985 Ma Haide (George Hatem) 1986 Lowell P. Weicker, Jr. 1988 Lewis Thomas 1989 Thomas P. O’Neill, Jr. Robin Chandler Duke 1991 S. WexlerNancy Paul G. Rogers 1993 Mark O. Hatfield 1995 John Edward Porter The Science Times of David J. Mahoney Harold P. Freeman 2000 William H. Foege 2001 ReeveChristopher 2003 Nancy G. Brinker 2005 Anthony S. Fauci 2007 The NewYork Times

Fred L. Soper Alfred Newton Richards 1946 1947 Martha M. Eliot R.E. Dyer 1948 Marion W.Sheahan 1949 Eugene Lindsay Bishop 1950 Florence R. Sabin 1951 Howard A. Rusk G. Brock Chisholm 1952 Earle B. Phelps Felix J. Underwood 1953 Leona Baumgartner 1954 Margaret G. Arnstein Pearl McIver U.S. Public Health Service Nursing of the Services Karl and William Menninger Robert D. Defries 1955 William P. Shepard 1956 Reginald M. Atwater C.J. VanSlyke Frank G. Boudreau 1957 Basil O’Connor 1958 Maurice Pate 1959 John B. Grant 1960 Oren Harris Melvin R. Laird 1963 Lyndon Baines Johnson 1965 Eunice Shriver 1966 Claude Pepper 1967

DESIGN MALCOLM GREAR DESIGNERS