albert and mary lasker foundation

110 East 42nd Street Suite 1300 New York, ny 10017 November 3, 2003 tel 212 286-0222 fax 212 286-0924 Greetings: www.laskerfoundation.org james w. fordyce On behalf of the Albert and Mary Lasker Foundation, I invite you to submit a nomination Chairman neen hunt, ed.d. for the 2004 Albert Lasker Medical Research Awards. President mrs. anne b. fordyce The Awards will be offered in three categories: Basic Medical Research, Clinical Medical Vice President Research, and Special Achievement in Medical Science. This is the 59th year of these christopher w. brody Treasurer awards. Since the program was first established in 1944, 68 Lasker Laureates have later w. michael brown Secretary won Nobel Prizes. Additional information on previous Lasker Laureates can be found jordan u. gutterman, m.d. online at our web site http://www.laskerfoundation.org. Representative Albert Lasker Medical Research Awards Program Nominations that have been made in previous years may be updated and resubmitted in purnell w. choppin, m.d. accordance with the instructions on page 2 of this nomination booklet. daniel e. koshland, jr., ph.d. mrs. william mccormick blair, jr. the honorable mark o. hatfied Nominations should be received by the Foundation no later than February 2, 2004. Directors Emeritus A distinguished panel of jurors will select the scientists to be honored. The 2004 Albert Lasker Medical Research Awards will be presented at a luncheon ceremony given by the Foundation in New York City on Friday, October 1, 2004.

Sincerely,

Joseph L. Goldstein, M.D. Chairman, Awards Jury Albert Lasker Medical Research Awards ALBERT LASKER MEDICAL2004 RESEARCH AWARDS

PURPOSE AND DESCRIPTION OF THE AWARDS

The major purpose of these Awards is to recognize and honor individuals who have made signifi- cant contributions in basic or clinical research in diseases that are the main cause of death and disability. The Award winners may reside in any country of the world.

The Awards are intended to recognize contributions that have opened new fields of research, advanc- ing novel concepts or their applications in a particular biomedical discipline. These advances may consist of a specific contribution or a long series of contributions that demonstrate the nominee’s significant leadership towards the development of research concepts or their clinical application.

A list of previous recipients of the Lasker Awards in Basic Medical Research, Clinical Medical Research and Special Achievement in Medical Science is included at the end of this booklet.

Each Award consists of an honorarium, a citation and an inscribed statuette of the Winged Victory of Samothrace, symbolizing victory over death and disease.

When the Award is given to more than one individual in a category, the honorarium will be divided among the winners, and each will receive a statuette and a citation. More than one scientist may be nominated if they have worked as a team, or if they independently have made comparable contri- butions in their field. No more than three individuals will be considered for an Award in the basic or clinical category.

The Jurors’ evaluations of the contributions of the nominees depend heavily on the information supplied in the nomination forms. Therefore, the nomination should be accurate, detailed, current and complete. Supporting letters that specifically address the nominee’s scientific accomplishments will be helpful to the Jury.

1 Basic Medical Research Award ($50,000)

This Award honors the scientist or scientists who have made fundamental investigations that open new areas of biomedical science.

Clinical Medical Research Award ($50,000)

This Award honors the scientist or scientists whose contributions, directly or indirectly, have led to the improvement of the clinical management or treatment of patients and to the alleviation or elimination of one of the major medical causes of disability or death.

Special Achievement Award in Medical Science ($25,000)

This Award was inaugurated in 1996. It honors a scientist whose contributions to research are of unique magnitude and immeasurable influence on the course of science, health, or medicine, and whose professional career has engendered within the biomedical community the deepest feelings of awe and respect.

NOMINATION INFORMATION REQUIRED FOR MEDICAL RESEARCH AWARDS

1) For all nominations, on page 5 please provide a suggested short citation which highlights the research for which you wish your nominee(s)’s to be recognized, and provide a short summary of the nominee(s)’s scientific contributions.

2) Questions 1 and 2 (on pages 6 and 7) apply only to Basic and Clinical Award nominations.

3) Nominators for the Special Achievement Award should utilize only pages 4, 5, and 8 from this booklet, and should follow other instructions below.

4) Please provide the following additional information: a) a brief one-page biography including awards received by each nominee; b) on an additional page, a list of six (6) peer-reviewed journal references that substantiate the state- ments made in your nomination. DO NOT send reprints.

5) Supporting letters from colleagues familiar with the nominee(s)’s work can be either included with the nomination package or mailed separately.

6) No nominations or support letters are automatically carried forward from previous years. If you wish to renominate a previous candidate, please update the earlier nomination and resubmit it by com- pleting this 2004 nomination form. The 2004 nomination should contain all the pertinent previous material submitted, including updated letters of support, and any significant developments in the research contributions which have occurred since the nomination was last submitted. Complete, updated information should be included to permit review of each nomination without reference to previous nominations.

2 7) Submit ONE (1) ORIGINAL and TWO (2) COPIES of the above requested information. Please do not staple or bind any of the material you are submitting. Instead, using binder clips, please arrange each set in the following order: the completed nomination forms; the brief one-page biography; the list of six peer-reviewed journal references; and any enclosed support letters.

8) Submit ONE COPY of a complete curriculum vitae, including publications, of each nominee.

9) The nomination and supporting letters should be received by the Foundation no later than February 2, 2004.

MAIL THE COMPLETED NOMINATION TO:

Albert Lasker Medical Research Awards 110 East 42nd Street, Suite 1300 New York, NY 10017 Attention: David Keegan

FOR INFORMATION OR ADDITIONAL NOMINATION FORMS, PLEASE NOTIFY DAVID KEEGAN AT THE FOUNDATION:

Phone: 212-286-0222 Fax: 212-286-0924 E-mail: [email protected]

Please note that nomination forms may be downloaded from our website (www.laskerfoundation.org) for printing purposes only.

Nominations should be received by the Foundation no later than February 2, 2004.

3 ALBERT LASKER MEDICAL2 RESEARCH00 AWARDS4 Please check the appropriate Award.

Basic Medical Research Award (no more than 3 nominees) Clinical Medical Research Award (no more than 3 nominees) Special Achievement Award in Medical Science (1 nominee only)

NOMINEE NAME

TITLE

ORGANIZATION NAME AND ADDRESS

TELEPHONE FAX E-MAIL

NOMINEE NAME

TITLE

ORGANIZATION NAME AND ADDRESS

TELEPHONE FAX E-MAIL

NOMINEE NAME

TITLE

ORGANIZATION NAME AND ADDRESS

TELEPHONE FAX E-MAIL

NOMI NATOR NAME

TITLE

ORGANIZATION NAME AND ADDRESS

TELEPHONE FAX E-MAIL

4 NOMINEE(S)’S NAME(S)

SUGGESTED CITATION FOR NOMINEE(S)’S AWARD (35 words or less).

SUMMARY OF NOMINEE(S)’S SCIENTIFIC CONTRIBUTIONS (150 words or less).

5 NOMINEE(S)’S NAME(S)

Please answer the following two questions regarding the nominee(s)’s scientific contributions.

1) WHY DOES THE NOMINEE(S)’S WORK REPRESENT A MAJOR ADVANCE IN EITHER THE BASIC OR CLINICAL SCIENCES AND WHAT ARE HIS OR HER ORIGINAL CONTRIBUTIONS THAT LED TO THIS ADVANCE?

LIMIT RESPONSE TO NO MORE THAN 2 PAGES 6 NOMINEE(S)’S NAME(S)

7 NOMINEE(S)’S NAME(S)

2) WHO IN YOUR OPINION SHOULD SHARE IN THIS AWARD AND WHY?

LIMIT RESPONSE TO THIS PAGE 8 NOMINEE’S NAME

NOMINATION FOR SPECIAL ACHIEVEMENT IN MEDICAL SCIENCE AWARD.

Please highlight the outstanding achievements of the individual whom you are nominating as well as your reason why he or she is deserving of recognition from the Lasker Foundation.

LIMIT RESPONSE TO THIS PAGE 9 ALBERT LASKER MEDICAL RESEARCH AWARDS 1946-2003 WINNERS

BASIC RESEARCH 1989 1978 1963 AWARDS Michael J. Berridge Hans W. Kosterlitz Lyman C. Craig Alfred G. Gilman* John Hughes 2003 Edwin G. Krebs* Solomon H. Snyder 1962 Robert G. Roeder Yasutomi Nishizuka Choh H. Li 1977 2002 1988 K. Sune D. Bergström* 1960 James E. Rothman Thomas R. Cech* Bengt Samuelsson* M.H.F. Wilkins* Randy W. Schekman Phillip A. Sharp* John R.Vane* F.H.C. Crick* James D. Watson* 2001 1987 1976 James V. Neel Mario Capecchi Leroy Hood Rosalyn S.Yalow* L.S. Penrose Martin J. Evans Philip Leder Ernest Ruska Oliver Smithies Susumu Tonegawa* 1975 James Hillier Roger C.L. Guillemin* 2000 1986 Andrew V. Schally* 1959 Aaron Ciechanover Rita Levi-Montalcini* Frank J. Dixon Albert Coons Avram Hershko Stanley Cohen* Henry G. Kunkel Jules Freund Alexander Varshavsky 1985 1974 1958 1999 Michael S. Brown* Ludwik Gross Peyton Rous* Clay M. Armstrong Joseph L. Goldstein* Howard E. Skipper Theodore Puck Bertil Hille Sol Spiegelman Alfred D. Hershey* Roderick MacKinnon* 1984 Howard M. Temin* Gerhard Schramm Michael Potter Heinz Fraenkel-Conrat 1998 Georges J. F. Köhler* 1971 Irvine H. Page Lee Hartwell* César Milstein* Seymour Benzer Yoshio Masui Sydney Brenner* 1957 Paul Nurse* 1983 Charles Yanofsky Isaac Starr Eric R. Kandel* 1997 Vernon B. Mountcastle 1970 1956 Mark S. Ptashne Earl W. Sutherland* Karl Meyer 1982 Francis O. Schmitt 1996 J. Michael Bishop* 1969 Robert F. Furchgott* Raymond L. Erikson Bruce Merrifield* 1955 Ferid Murad* Hidesaburo Hanafusa Karl Paul Link Harold E. Varmus* 1968 Carl J. Wiggers 1995 Robert C. Gallo Marshall W. Nirenberg* Peter C. Doherty* H. Gobind Khorana* 1954 Jack L. Strominger 1981 William F. Windle Edwin B. Astwood Emil R. Unanue Barbara McClintock* John F. Enders* Don C. Wiley 1967 Albert Szent-Gyorgyi* Rolf M. Zinkernagel* 1980 Bernard B. Brodie Paul Berg* 1953 1994 Herbert W. Boyer 1966 Hans A. Krebs* Stanley B. Prusiner* Stanley N. Cohen George E. Palade* Michael Heidelberger A. Dale Kaiser George Wald* 1993 1965 Günter Blobel* 1979 Robert W. Holley* 1952 Walter Gilbert.* Sir F. MacFarlane Burnet* 1991 Frederick Sanger* 1964 Edward B. Lewis* Roger Wolcott Sperry* Renato Dulbecco* Christiane Nüsslein-Volhard* Harry Rubin * Denotes Nobel PrizeWinner 1951 1997 1980 1964 Karl F. Meyer Alfred Sommer Professor Sir Cyril A. Clarke Nathan S. Kline Ronald Finn 1950 1996 Vincent J. Freda 1963 George Wells Beadle* Porter Warren Anderson Jr. John G. Gorman Michael E. DeBakey David H. Smith William Pollack Charles Huggins* 1949 John B. Robbins André Cournand* Rachel Schneerson 1978 1962 William S. Tillett Michael Heidelberger Joseph E. Smadel L.R. Christensen 1995 Robert Austrian Barry J. Marshall Emil C. Gotschlich 1960 1948 Karl Paul Link Vincent du Vigneaud* 1994 1977 Irving S. Wright Selman A. Waksman* John Allen Clements Inge G. Edler Edgar V. Allen René J. Dubos C. Hellmuth Hertz 1993 1959 1947 Donald Metcalf 1976 John Holmes Dingle Oswald T. Avery Raymond P. Ahlquist Gilbert Dalldorf Thomas Francis, Jr. 1991 J. W. Black* Robert E. Gross Homer Smith Yuet Wai Kan 1975 1958 1946 1989 Godfrey N. Hounsfield* Robert W. Wilkins Carl Ferdinand Cori * Etienne-Emile Baulieu William Oldendorf 1957 1988 1974 Rustom Jal Vakil Vincent P. Dole John Charnley Nathan S. Kline CLINICAL RESEARCH Robert H. Noce AWARDS 1987 1973 Henri Laborit Mogens Schou Paul M. Zoll Pierre Deniker 2003 William B. Kouwenhoven Heinz E. Lehmann Marc Feldmann 1986 Richard E. Shope Ravinder N. Maini 1972 Myron Essex Min Chiu Li 1956 2002 Robert C. Gallo Luc Montagnier Roy Hertz Louis N. Katz Willem J. Kolff Denis Burkitt Jonas E. Salk Belding H. Scribner 1985 Joseph H. Burchenal V. Everett Kinsey Bernard Fisher V. Anomah Ngu Arnall Patz 2001 John L. Ziegler Robert G. Edwards 1984 Edmund Klein 1955 Emil Frei III Paul C. Lauterbur* C. Walton Lillehei 2000 Emil J. Freireich Morley Cohen Harvey J. Alter 1983 James F. Holland Herbert E. Warden Michael Houghton Donald Pinkel Richard L. Varco F. Mason Sones, Jr. Paul P. Carbone The Hoffmann-La Roche 1999 1982 Vincent T. DeVita, Jr. Research Laboratories David W. Cushman Eugene J. Van Scott Squibb Institute for Medical Roscoe O. Brady Miguel A. Ondetti Isaac Djerassi Research Elizabeth F. Neufeld C. Gordon Zubrod Edward H. Robitzek 1998 1981 Irving Selikoff Alfred J. Knudson, Jr. 1965 Walsh McDermott Louis Sokoloff Peter C. Nowell Albert B. Sabin Carl Muschenheim Janet C. Rowley

* Denotes Nobel PrizeWinner 1954 1997 1984 1957 Alfred Blalock Victor A. McKusick Henry J. Heimlich Frank G. Boudreau Helen B. Taussig C.J. Van Slyke and Robert E. Gross 1996 1983 Reginald M. Atwater Paul C. Zamecnik Maurice R. Hilleman (posthumously) 1953 Saul Krugman Paul Dudley White 1994 1956 Maclyn McCarty 1979 William P. Shepard 1952 Sir John Wilson Conrad A. Elvehjem 1955 Frederick S. McKay 1978 Robert D. Defries H. Trendley Dean PUBLIC SERVICE The Honorable Elliot L. The Menninger Foundation— AWARDS Richardson Drs. Karl and William 1951 Theodore Cooper Menninger Elise L’Esperance 2003 Nursing Services of the U.S. 1976 Public Health Service— Catherine Macfarlane Christopher Reeve William G. Lennox World Health Organization Lucile Petry Leone Frederic A. Gibbs 2001 Pearl McIver 1975 Margaret G. Arnstein William H. Foege 1950 Jules Stein 1954 George Papanicolaou 2000 1973 Leona Baumgartner Betty Ford 1949 Warren Magnuson, Harold P. Freeman 1953 Max Theiler* David J. Mahoney United States Senator Felix J. Underwood Edward C. Kendall* The Science Times of The New Earle B. Phelps Philip S. Hench* York Times 1968 (posthumously) Congressman John Edward Porter Lister Hill, United States Senator 1946 1952 John Friend Mahoney 1995 1967 G. Brock Chisholm Carl Landsteiner* The Honorable Mark O. Hatfield Representative Claude Pepper (posthumously) Howard A. Rusk Alexander S. Wiener 1993 1966 Philip Levine 1951 Paul G. Rogers, Esq. Eunice Kennedy Shriver Florence R. Sabin Nancy S.Wexler 1965 1950 SPECIAL ACHIEVEMENT 1991 Lyndon Baines Johnson, President of the United States Eugene Lindsay Bishop IN MEDICAL SCIENCE Robin Chandler Duke Thomas P. O’Neill, Jr. 1963 1949 2002 1989 Congressman Melvin R. Laird Marion W. Sheahan James E. Darnell. Jr. Congressman Oren Harris Lewis Thomas 1948 2000 1988 1960 R.E. Dyer, M.D. Sydney Brenner* Martha M. Eliot Lowell P. Weicker, Jr., John B. Grant Abel Wolman 1999 United States Senator 1947 Seymour S. Kety 1986 1959 Alice Hamilton Maurice Pate 1998 Dr. Ma Haide (George Hatem) 1946 Daniel E. Koshland, Jr. 1985 1958 Alfred Newton Richards Fred L. Soper Lane W. Adams Basil O’Connor Ann Landers—Eppie Lederer

* Denotes Nobel PrizeWinner