The Newsletter of the NIH Alumni Association
Summer 1993 Vol. 5, No . 2 date Nobel Laureate Harold Varmus Nominated as 14th NIH Director Ruth Kirschstein Named Acting Director President Clinton on A ug. 3 announced his intention to nominate Dr. Harold Eliot Varmus as the 14th director of th e National Institutes of Health. A Senate confirmation process must precede Yarmus· taking over leadership of the institutes. Winner of the Nobel Prize in 1989 for his work in cancer research. Va1111us. 53. is a professor of microbi ology. biochemistry. and biophysics. and the American Cancer Society pro fessor vfmoh:cu/ur >1iro/O£)' iJI l/Je Uni versity of California, San Francisco. He is a leader in the stu dy of cancer causing genes called "oncogenes," and an intemationall-y fecogni:z.ed authof\t-y Dr. Ruth l. Kirschsteln , acting NIH director on retroviruses. the viruses that cause Dr. Harold E. Varmus , direclor-designale AIDS and many cancers in animnl.. FIC 25 Years Old In '93 Thirty-eight-year NIH veteran Dr. Research Festival '93 Schedule Ruth Kirschstein. director of NIGM S Scholars-in-Residence (See Director p. 6) NIHAA Members Invited Program Celebrates To Alumni Symposium In This Issue Tile fas\ morning ofNCH Rc:-.c;\rch Nursing cell/er /J1·1·111111•s Festival '93-Monday. Sept. 20-has This year. the Fogarty Intern ational 17th i11s1it11tc• 111 NII/ p. ? been designated National lnsritute of Center (FIC) is 25 years old . T he cen Greeri11gs from 1/,11 1w11• NII /AA prl'sidt'lll. Diabetes and Digestive and Kidney Tltolll(IS .I. K 1•1111edy. .Ir. fl. 3 ter was created by Executive Order in Diseases Alumni Day. This event is Cale11dar fl· .J 1968 as a memorial to the late Rep. being celebrated with a symposium Ne11•s fro111a11d11/m111 NIIlt\A mc•m/Jers John E. Fogarty who. during his long entitled ..Contribution of Basic Science mul/ oreip,11 chafltt•rs fl· 9 career as a congressman from Rhode to Biomedical Research.. sponsored by Sde11cl' research updm<·s i11 Island. became a powerful advocate of //1111w11 g1·111•1i1·.w11tli1•s fl.l.J N IH and NIDOK in honor of Dr. internat ional collaboration in health /low i111em111i<11w/ i.v Niii? p.18 Elizabeth F. Neufe ld, recipient of the research. In his later years in Congress, I frrhert G111frc1111d re111i11i,,·ces 1993 Distinguished A lumni A wmd. he became deeply interes ted in imern a aho111 his years as PICsd1nlar 11.19 Neufeld was chosen for her outstand tional health and was often a member A loo~ at Sw11e lloutc p.10 ing contributions toward the under of the U.S. delegation to the World AIDS co11fen•111·e to /I(' ht'itl m NII/ 11.21 standing and diagnosis of a group of Health Assembly where he advocated 81·rnadi111• l-lealy·s prrfiw1· 111 hereditary diseases known as mucopoly ··111\'es11111•111for l/111111111i1y" p.22 collaborative research at the intern a saccharide storage disorders. including Niii Not1'.t 11.2.> tional level. Hurler's and Hunter" s syndromes. Niii Re1ms/1<'ctin'.1 11.30 W hen the FlC was founded th e These often fata l disorders are charac Cli11irnl Cemer .Jll//1 a1111i1·1•rs11ry Scholars-in-Residence Program was c1•/l'im11itJ11 higlilightl'll 11.31 terized by an excessively high accumu crcaiccl to bring biomedical scientists lation ofmucopolysaccharide. within (see Scholars p . I 7) (See Symposium p. 7) N I H A A UPDATE
Nursing Center Becomes 17th Institute at NIH Thank you to our friends Whai"s in a name? If the staff of the The NIH AA wannly welcomes the fol new National lnstitute of Nursing lowing organizations that joined in the cate Research were asked this question, the gory of..Friends .. and wishes to acknowl edge its apprec iation for their generous answer would surely be "a lot more support: than one would think." Formerly the A111erica11 Association ofRetired National Center for Nursing Research, Persons the newly created institute, its staft, U11iwrsity ofAlabama School of friends. colleagues and the nursing Medicine at Birmingha111 Amerirnn Cvc111a111id community are looking forward to cele Boehringer ingelheim brating the new status. Boehri11ger Mannheim "People ask me why institute status NATIONAL INSTITUTE OF N URSING RESEARC H Unfrersity ofSouthern California is so important.'' said Dr. Ada Sue The National Institute of Nursing Research School ofMedici11e Florida Clinical Practice Association. Hinshaw. NINR director. ;'I tell them logo. The NR stands for nursin gresearch , Inc. that it is a matter of perception, which and the fl ame symbolizesknowledge. Hmw rrd Unfrersity Sc/roof ofDe111al includes a sense of stabi lity, stature and Medicine something I am proud ro support.·· importance for nursing research within Unfrersiry ofIowa College of The institute·s pw·pose is to provide a Medicine the health research community." strong scientific base for nursing prac R. W . .lolrnson Phar111ace111ical The change from center to institute Research lnsti1111e tice, answering such questions as: how began on the evening ofJune I 0, when Marion Merrell Dow Research lnsriwte can nurses help mothers-to-be prevent President Clinton signed the NJ 1-1 Revi Mehar1:,· Medical College low birth weight babies? How can the Miles. /11 c. talization Act of 1993, thus creating the extent of a child's pain be dete1mined Unfrersity ofMinnesota Program in N INR. a mo ng other things. HHS Critinil Cun: S11rge1y so that the right help can be given? Secretary Donna Shalala then signed U11i1-ersity ofNorth Carolina Sc/root of What can nurses do to help women deal the corresponding Federal Register Medicine w ith the typical symptoms of meno Parke-Dal'is Plwrmacewical Research notice on June 14, which formally added pau se? How can older people live Pe1111 Sime Unirersity College of the seventeenth insti tute to NlH. In her Medicine & Unirersi1y Hospiwl independent lives as long as possible? press release announcing the NlNR. Mediwl College ofPen11syfl'(l11ia Jn addition to ameliorating illness, Smi//1Kli11e Beeclram Secretary Shalala said, " I nm particular nurse scientists study health promotion Unil'ersity ofTe111ressee College of ly pleased that nursing research has and disease prevention. including how De111isrrv received this recognition. Nursing Wye//1-Ayerst to moti vate people to adopt healthy research makes a vital contribution to lifestyles. lnnova tive approaches are We also would like IO thank Glaxo Inc .. improving th e nation's health. Strength Sandoz Research lnstiLUte and 1he Upjohn also developed and tested to improve ening th at research role is certain ly Company for bearing the considerable the delivery of health care through high expense of underwriting NIH AA Upd(J[l'. quality nursing services. N ursing The Foundation for Advanced Education research is strongly collaborative. in the Sciences (FAES) has generously and continually supported NTHAA. Nurse scientists work closely with We would also like to express our deep many health disciplines to find answers appreciation 10 1he following contributors to to health problems. Nll-IAA -sponsored events in 1992: According to Hinshaw . ..What has Clrarles Rfrer Laboratories been especially gratifying is the sup Nmirmal For111dc11io11 for Infectious Diseases port. encouragement and assistance of Peptide Technology Limited our NIH colleagues dating from the Ta/.:aro S/r11:0 Co.. Ltd. time we first arrived on campus in Wamer-La111ber1/Parke·D(/\·is 1986. We lpok forward ro continuing Plwr111ace11tical Researclr. OLLI' good relationships and productive Credit collaborations as we all work towards NIHAA Updme is supporred by gr<1111sfro111 furthering re search in the interest of Ghr.ro Inc.. Sando: Research l11sti1111c and Dr. Ada Sue Hinshaw good health.,. tire Upjolrn Comptmy.
2 SUMMER 1 9 9 3
Greetings from the New NIHAA President, Thomas J. Kennedy, Jr. The NIHAA Updme is the 11ell'sleuer ofthe NIH Alumni A.1·sotiatio11. The NIHAA office The high light~ r perhaps more is a1 9!01 Old Ce(Jr gc1ow11 Rd .. Bct!tesdo. accurately. the l ow li ght~f the past MD 20814. (301) 530-0567. year was the calamity th at befell Joe Editor's Note Held. president of NlHAA. Out of the The NIHAJ\ Updme ll'elcomes leuers and blue last October he had a serious intra news from readers. \Ve wish not only to cranial hemorrhage from an aneurysm: bring alumni news about NI/-/ , bw also to sen 1e as a means f or reporting information was suspended precariously between about al11 11111i- their co 11cems. information life and death for a seemingly endless 011 recent appointments. honors. books pub period, and then hung for an agonizing lished and other de1·elopmews ofiwerest to their col/eag1ll!s. If you lull'e 11ell'S about ly extended interval in a state in which 1•011rse/f or a/Joi// otlter al1111111i, or com th e completeness of recovery was in i11ems "" and s11ggestio 11 .~fo r the NIHAA deep doubt. But I guess it was a high Update. plettse drop a note to the ediwr. We reserl'e the right to edit materials. light after all because. all of a sudden. Editor: Harriet R. Greenwald everything changed for th e beuer and Joe is now his old self-energetic, full NIHAA Newsletter Etlitorial i\dvisory Committee or bright ideas, and working hard to Robert G. Martin. Clwirman Dr. Th omas J. Kennedy, Jr. Linda J. Brown Michael M. Goffe.mum inspire us all onward and upward. Jerome G. Green Harriet R. Greenll'ald Again. personal experience brings tion of imramural research at 11-1 . Victoria A. /larden Col/ee11 He11ric/1se11 home th e realization th at modern medi f/ m·ve}' Klein Almer Louis Nmkins John Sherman presented the NI HAA Lois A°.Sal:111a11 Philip£. Sclwmbra cine is full of wonders. Public Service Award. a framed water Eli:abeth II. Singer Richard G. \Vytw During Joe's long incapacity. John color of the William 1-1 . 1atcher Bldg. N!HAA News /el/er Board of Co11trib11ti11g Editors Sherman. vice president. and Cal done by Stonn Whaley. retired associ Giorgio Bemardi N. Fra 11 /.:li11 8 111111 Baldwin, secrewry-treasurer. stepped ate direc tor for communications and Bernard D. DMis Roger 0. £11eberg into the breech smartly and kept rh e NlHAA board member. Enriched with lfrnrrk Eisenberg Donald S. Fredritk.wm Lars A. Hanson Walter W. Holland board functioning . moothly. We owe appropriate sentiments. the presentation George Klein Richard M. Krause both a big vote of thanks. had the intimacy and immediacy of a Robert Q. Mt1rston Carlos Monge T he headline on one story in the last citation th at could only come from a Roger Monier Seymour Pl'rt )' Michael Selt1 issue of rhe Update jumped th e gun by collabora1or who had known and NIHAA /Joard of Directors and Officers a soup9on. Rep. W illiam 1-1 . Natcher admired the awardee for almost as long Thomas .I. Ke1111er. .Ir .. Presidem (D-Ky.) got his .. brick and monar" as the la11er had served on the House Calvin 8. IJaldwii1 . .Ir.. Vice Preside/I/ recognition as deseribed. when ground appropriations committee. Mr. .loli11 P. Sl1emw11. Vi<·e President was broken in September 1992 for th e Natchc1"s acceptance-courtly. modest Marr£. Sears. Secretll/'\' Nariey G. S!tej]ield. Trei1.mrer new building on the NIH campus th at and moving-made incontestably evi Joe R. lleld. President 1991-1993 will bear his name. However. it was dent his convictions about the mar Gordon D. Wallace. President 1990-1991 not until the annual meeting of the velous promise that biomedical Nmha11il'l I. /J(' rli11 Wi/lit1m R. Carmi/ NIHA A on M ay 15. 1993. that our research holds for 1he health and well Belia L. Ceja Peter Cvndliffe Marguerite Coomes J. Richard Cmw organization's first Public Service being of the American people. He .loh11 L. Dec~er .lames T. Duff A ward was bestowed. The occasion earnestly solicited our advice in helping Gio B. Gori Mary Calley 1-/artman was a very joyous and heartwarming him make rhe right decisions on the /.eon .lambs Willit1111 S . .Jordan, .Ir. lloward Kefll .lo.1·eph Keyes . .Ir. one. Mr. Natcher came early and scope. direction and magnitude of Tt'l'I')' L. Lierman Thomas E. Malone stayed late. Before his invcstilllre. he national programs in biomedical and Clwl·les Miller. II Paul Parkman mingled with a splendid turnout of our behavioral research in both his fom1al Joseph Perpil'h Sew11011r Perrr Paul Q. Pt'terson Dm•id P. Rail members and heard a most illuminated acceptance speech and his personal and Man•in Sc l11ll'idt•mu111 Rr111dv Sl'lwols review by Lance Liott a. deputy director informal conversations with members llrl(' 11 R. SC'l1mc>der Ril'lu1rrt'L. St•gfiel l'or intramural research, about the cur after the meeting was adjourned. Emma Sltdw11 S11sa1111e A. Stoi/Jc>r John P. Ur: Srorm \Vlialey rent status as well as the future direc- (See Greetings p . ./)
3 N I H A A UPDATE
Greetings (co111i1111ed from p. J) Betimes. to our surprise and delight, he sat through the routine. perhaps tedious, ritual of an annual business meet ing. Mr. Natcher"s ex traordinary commit ment to improving the health or people through research became ev ident again recently when th at "olc magician'' pulled al least fi ve rabbits out or the hat to add more than $600 million over last (FY 1993) year"s level and $269 mil lion over the Prcsident·s request for th is year to the 1-l ouse·s appropriation for NIH in what is probably the most grim budget year in th e last forty. Since the Senate will not act until September. the final Congressional word has yet to be spoken. But there is no doubt as 10 where Bill atcher"s heart lies. Acting NIHAA President John Sherman (I) pre sents to Rep. William H. Natcher (D-Ky.) the The Nll-IAA annual meeting ra tified 1993 NIHAA Public Service Award . the slate of officers and board members elected by the members and the board: a wann welcome from a distinguished heard from Richard Klausner his per these are listed on p. 3 in the masthead. group of NIH scientists and had the sonal saga, a clinical associate of yes Nat Berlin, in residence at N II-I for a opponunity to socialize with them in teryear and now just elected to the sabbatical. was pressed into service to the congenial atmosphere of the Mary NAS; and soothing words ofencour help the A lumni Association design an Woodard Lasker Center. T hey also agement were offered by two young event, perhaps an annual one, th at would enable ii to make a rinite and visible contribution to the advancement of public policy in the domain of bio medical research. Working alone at first. but gradually picking up A lan Schechter. Gordon Wallace. John Sherman and yours tru ly as collabora 1ors. a '"Fonun on th e Future of Bio medical Research.. is now in a late state of gestation. Stay tuned for details. The Alumni Association. on June 30, 1993. the eve of the new ··house staff' year. cosponsored w ith the Office or Education. a reception for the incoming clinical associates. This was the sec ond consecutive year in which we played this role and it is our hope that th e reception and NIHAA's role in it Dr. Bruce Chabner, director of the Division of Cancer Treatment, NCI, talks with two of the will become a regular item on the N IH incoming clinical associates at the welcoming reception on June 30 at the Mary Woodard Calendar of Events. The tyros received Lasker Center.
4 SUMMER 1 9 9 3
Calendar of Exhibits and Upcoming Events scientists, Griffin Rodgers, NIDDK. and Michele Evans. N IA . wh o had bers of the N IH A lumni Association started as clinical associates in just the September-December have been invited to tour the newly last few years. M any of you probably An exhibit in honor of the 500th anni opened Howard Hughes Medica l remember the an xieties and misgivings versary of ..Paracelsus and the Medical Institute. 4000 Jone Bridge Road. that plagued you as you embarked upon Revolution of the Renaissance·· is on Chevy Chase at 2:00 p.m. Postcards your stint as a clinical associate. It was display in the front lobby of the N LM with detnils will be mailed in a nice affair! That's th e sort of thing (Bldg. 38, 8600 Rockville Pike) unt il September LO local chapter members. your dues money supports. Dec. 3 1. For furth er information call On T hursday. Oct. 2 1, 1993. from The A lumni A ssociation is gradually Dr. Philip Teigen at the History of Medi 5:30 to 7:30 p.m. the NIHAA will hos t expanding both what ir is doing and its cine Division. NLM, (30 I) 496-5405. a reception at the Embassy of the ambitions for what it would like to do Federal Republic of Germany to honor to assist N IH. My interactions w ith the the visiting German cientistS at IH. members of th e association who volun September-November Invitation:.. w ill be mailed in teer their time and effort so generously Research Festival '93 September. have persuaded me th at all feel th ey Sept. 20-NIH/NIDDK A lumni owe a profound debt of gratitu de to this Symposium on M onday morning October- April 1994 grem federal agency, the National from 8:45 to 12 noon in Masur lnstillltes of 1-l ealrh. T he only limita Auditorium. Bldg. 10. The r:oundation for Advanced tions on repayment are our ability to Sept. 20. 2 1 and 22-Adcl itional sym Education in th e Sciences. Inc .• will conceive ways to do it and our capabili posia, workshops and coord inated sponsor nine concerts in the 1993-94 ty to amass the resources to concretize poster sessions season. our aspirations. Thus the board and Sept. 23 and 24-Technical Sales The concert dates are: officers solicit and welcome the Association Scientific Equipment Oct. I 0-Peter Serkin. piano thought and ideas of the members on Show Oct. 17-Tokyo String Quartet activities th at could be incorporated Nov. 2 1- Ridge En semble with C. Medicine for the Public: into NIHAA ·s agenda. Obviously, our Raim. piano reach hus long exceeded our grasp- Sept. 28-Glaucoma: Don' t Lose Sight Jan. 30. 1994-Richard Goode, piano the damnable fate of all impecunious of lt Feb. 13-Trio Fontaney organizat ions committed to great cau ses. Oct. 5- Understanding the Healing Mar. 13-Emanuele Segre, guitar. and In the past year, the NlHAA has Arts: Alternative Medicine at NIH Friends begun to try to enlist institutional mem Oct. 12- Uptight or Laid-back: How Mar. 27-Michel Lerhiec and Friends bers from among individuals and orga We Handle Stress Apr. I 0-Duo Canino-Ballista nizations that also have reason to be Oct. 19-Blood Transfu sions: I ssues Apr. 17-Auryn String Quartet grateful for the NIH-dri ven advances in and Answers May I-Andras Schiff and Y uuko science and that are in a much beuer Oct. 26-Spinal Cord Injury: New Shiokawa (this concert has been position to provide additional impetus Developments in T reatment rescheduled to replace the concert of to our effons. If you have the ear of Nov. 9-0besity: The Whys and Mar. 14, 1993. canceled because of any such potential contributors, encour W herefores snow). age them to make common cause with A lecture series on health and disease Concert s arc held on Sundays at 4 us. A lso, strange as it may seem, the sponsored by the Clinical Center, NIH. p.m. in Masur A uditorium. Bldg. 10. NIH has neither a record of who has The lectures are free and held on Tues T ickets arc required. For more infor worked on the campus nor any ideas as day evenings at 7 in Masur A uditorium, 1nation call (30 I ) 496-7976. to how former staff can be located. For Bldg. I 0. For informat ion call (30 I ) that reason. please let us know the 496-2563. For more infonnation about various whereabouts of any of your er. twhile lectures and events at NIH. call (30 1) Bethesda colleagues who are not now October 496- 1766. For information about members of the NIHAA. On Saturday. Oct. 9. 1993. the mem N IHAA call (30 1) 530-0567.
5 N I H A A UPDA T E
responsible for causing 1umors in commi11ee that advised the Department Director (comin11ed from p. I) chickens. they discovered a nonviral src of Defense on the use of $2 10 million ror th e past 19 years, took over on July gene. very similar 10 v-src. presenl in allocated by Congress last year for I as acting NIH director ar the request the nom1al cells of birds and mammal s. breast cancer research. In J 986. he of Secretary Shalala. who also elevated In recelll years. his work has chaired the subcommittee of 1he Kirschstein 10 status as IH deputy assumed special relevance to A IDS , lmernmional Committee on 1he di rec tor. 1hrough a focus on biochemical proper Taxonomy of' Viruses thal gave the ·The role of an acting director or ties of HIV. and LO breast cancer. A IDS virus its name HIV. NIH is to maintain stability and the cur through investigation of mammary Varmus was born Dec. 18. 1939. and rent activities of IH as a whole in an tumors in mice. His research activities auendcd public schools in Freeport. appropria1c and excclle111 fashion so arc curremly supported by grants from Long Island. N. Y. ; his father Frank that the new NIH direc1or can move NIH. including an Outstanding prac1iced family medicine. and his right in:· said Kirschs1cin. Investigator Gram from NCI, a drug mother Bearrice was a psychiatric .. I want everyone at IH to know cl iscovery program for A IDS from social worker. He is a graduate of 1ha1 there will be no long interim period N I A ID. and a structural biology pro Amherst College (B.A. 196 1). where he when th ere's no one in ch
6 SUMMER 1 9 9 3
Symposium (continued f rom p. I) Arthur Kornberg, Stuart Korn feld, and the cells and ti ssues. leading to skeletal Jack Strominger, the program is of abno1malities, mental retardation, interest not only to fonner NIH'ers, but blindness. and deafness. al so to the present NTH intramural com She demonstrated that this group of munity. disorders results from defects in It is hoped that NTHAA members degradative enzymes. resulting in wi ll return to the Bethesda campus, mucopolysaccharide accumulation in attend the NIDDK symposium, and the lysosomes, thus defin ing these dis stay co panicipate in the activities that eases as lysosomal storage disorders. wilJ fo llow. The 1993 NTH Research Festi val will continue Monday afternoon, Sept. 20 with a plenary session on "Clin ical Applications of Gene Therapy." This year's organizing committee, chaired by Dr. [rwi n Kopin, NLNDS scienti fic director. has chosen "Molecular The NIH Oistinguished Alumni Award is a Medicine'' as the general theme. On replica of the statue "Healing Waters" by (See Symposium p. 8) Azriel Awret, which is located near the escalator on the first fl oor of Bldg. 10.
National Institute of Diabetes and Digestive and Kidney Diseases 1993 Distinguished Alumni Symposium Monday, Sept. 20, 1993 Masur Auditorium 8:45 a.m. - 12 noon
Opening Rema rks Dr. J ack Strominger Dr. Phillip Gorden Harvard University Dr. Elizabeth f . Neufeld Director, NIDDK 8:45 a.m. Presentation ofPeptides to the Her work led to an ability Lo diagnose Immune System by Cl(ISS I c111d correctl y these disorders in pati ents and Speakers Class II Major 1-listocompmibiliry to the development of prenatal screen Dr. Robert J. Lefkowitz Complex Molecules 10:20 a.m. ing for these diseases. In addi tion to Duke Uni versity Medical Center providing deeper insights inro the Molecular Approaches to l111erdict Dr. Stuart Kornfeld mechanisms of basic cell biology. her Signalling or Desensiti:ation of Washington University School of work has possible implications for G Protein-Coupled Receptors Medicine enzy me replacement therapy LO treat 8: 50 a.m. Trafficking of Proteins to these cond itions. Dr. Richard Axel Lysosomes I0:50 a.m. Neufeld was a biochemist with Howard Hughes Medical Insti tute, NIDDK from 1963 to 1984. during Colum bia University Dr. Elizabeth F. Neufeld which ti me she served as chi ef of the The Moleculcll' Biology o.f' Smell UCLA School of Medicine Genetics and Biochemistry Bra nch. 9:20 a. m. The Hurler Syndrome. Revisited Presently, she is professor and chair of Dr. Arthur Kornberg I I :20 a.m. the department of biological chemistry Stanford University School of Presentation of Distinguished at the UCLA School of Medi cine. Medicine Alumna Award by Dr. P hillip Ln honori ng Elizabeth Neufel.d as For tlte Lo11e of Enzymes 9:50 a.m. Gorden I I :50 a.m. NIDDK alumna of 1993. and with Richard Axel, Robert Lefkowitz.
7 N I H A A U P D A T E
Symposium (co111i1111edfro111 p. 7) Tuesday. Sept 21, there will two sym NIH Research Festival '93 General Schedule of Events posia. both scheduled for the morning on "Transcriptional Comror· and MONDAY, SEPT. 20 "Cellular and Functioning Imaging ... Symposia On Wednesday. Sept. 22 in the mom 8:45 a.m.-12:00 noon NfDDK Alumni Symposium: ing there also will be two symposia on Comribmions ofBasic Science to Biomedical Research "'Signal Transduction and intracellular Bldg. 10. Masur Auditorium Trafficking" and ..Biobehavior and 2:30 p.m.-5:00 p.m. Plenary Session: Clinical Applications ofGene Therapy Health" (See blue sidebar). Bldg. 10, Masur Auditorium Fort y-six interactive workshops will Poster Session L be conducted on Tuesday and 12:00-7:30 p.m. Posters (See poster session listings) Wednesday, which will highlight topics Research Festival tents, Park ing Lot 10-0, soulhwesr of Bldg. 10 of particular interest to researchers from NI H's diverse intramural pro TUESDAY, SEPT. 21 gram. They wi ll be held in various Symposia locations throughout the campus. 8:30-1 I :00 a.m. Transcrip1ionol Control Bldg. I0. Masur Auditorium There will be two equal-length poster 8:30-1 I :00 a.m. Cellular and F1111ctio11al lmogint: sessions al the fest ival. one on Monday, Bldg. 10, Lipsett Amphitheater Sept. 20 and another on Tuesday. Sept. Workshops 1·15 2 1. Five hundred posters will exhibit 2:30 p.m.-5:00 p.m. See workshop listings for titles and locations some of the work being done in NI H Poster Session 2 laboratories. The posters wi ll be dis 12:00-7:30 p.m. Posrers (See poster session listings) played in the Research Festival tents Research Festival tents in Parking Lot 10-0. southwest of Bldg. 10 that will be set up in parking lot I0-0 southwest of the Clinical Center. WEDNESDAY, SEPT. 22 The Technical Sales Association will Symposia provide refreshments for each poster 8:30 a.m.-11 :00 a.m. Signal Tro11sduc1io11 (Jf/d /111racel/11lar Tmfficking session. No picnic wi ll be held this Bldg. 10, Masur Auditorium year. Thu rsday. Sept. 23. and Friday, 8:30 a.m.-1 1: 00 a.m. Biobehavior and Heafl/1 Sept. 24 have been reserved for the Bldg. 10. Lipsett Amphitheater TSA scientific equipment show in the Workshops 16-46 Research Festival tents. There will be 8:30 a.m.-1 1: 00 p.m. Workshop 16-30 See listings for ti tles and locations over 300 exhibitors: it is one of the 2:30 p.m.-5:00 p.m. Workshop 31-45 See listings for titles and locations largest shows on 1he east coast. 8:30 a.m.-5:00 p.m. Special Workshop 46 The Research Festival wa. started 8 Comp11101io11 and Theore1ical Me1hodsfor Molecular Medicine Bldg. 12A years ago by Dr. Abner Notkins. former THURSDAY, SEPT. 23 AND FRIDAY, SEPT. 24 director of intramural research. NIDR. Technical Sales Association (TSA) Equipment Show Efforts by Notkins. subsequent com 9:30 a.m.-4:00 p.m. Exhibits mi11ee chairpersons. the addition of the Research Festival tents in Parking Lot 10-0, southwest of Bldg. 10 Al umni Symposium presentations fou r years ago, and the NIH Special Projects Programs with complete listing of symposia, posters and workshop titles Orficc headed by Thomas Flavin , have and locations will be available at the Visitor In formati on Center in Bldg. 10 made the event a great success. and in 3 1A. Shuttle bus service will be available on a frequent and regular The booklet detailing workshops and basis throughout the NIH reservation during the festival. Parking spaces in poster sessions is now available. For the 41-B lot will be available. but limited in number. Registration is not information call the NIHAA office at required for any of the events. For more information call the NI H Visitor (30 1) 530-0567 or the NIH Visitor Information Center at (30 1) 496-1 776. Information Center at (301) 496-1776.
8 SUMMER 1 g g 3
News From and About NIHAA Members, and Foreign Chapters
College of Physicians the John Phillips rant living in Greenwich, Conn. She Dr. David Axelrod, who was at NTH Memorial Award for his distinguished has written a book on Knowing in the Laboratory of Biology of contribmions in clinical medicine. Yourself The book was written in col Viruses. NIALD, from 1962 to 1965 Over the past 27 years, he has pio laboration with Dr. William H. and then a virologist al Nll-l from 1965 neered many studies in immunology. Hampton. to 1968, became New York State microbiology and rheumatology that Commissioner of Health in 1979. He have improved the understanding of the Dr. George CaneUos, chief of med retired in 199 1 because of a severe molecular basis of antibody function, ical oncology at the Dana-Farber stroke. Friends of his have establi shed the properties of immunoglobulins. Cancer fnstitute, Boston, who was at an endowment in his honor to support gene sequencing and the sequencing of NCI from 1963-65 as a clinical associ fellowships at the State University of antibodies. ate, then from 1967-74 a senior investi New York. School of Public Health, gator, and from 1974-75 acting clinical which he founded. Contributions and Dr. Baruch S. Blumberg, who was director, has assumed the presidency of iofomiarion may be referred to the in the geographic medicine and genet the American Society of Clinical Dav id Axelrod Public Health ics section ofNIAMD from 1957 to Oncology. Endowment, Administration Bldg., 1964, is master ofBalliol College at Rm. 23 1, The Uni versity of Albany Oxford Universit y, England. He was Dr. Paul Carbone, who was at NCI Foundation, 1400 Washington Ave.. inducted in to the National In ventors from l %0 to 1976 in the Di vision of Albany, N.Y. 12222. Hall of Fame this spring, along with Cancer Treatment, Medicine Branch, is Dr. Irving Millman, adjunct professor director of the University of Wisconsin Dr. J. Claude Bennett, who was a of microbiology al Hahnemann Comprehensive Cancer Center. research associate in molecular biology Uni versity, Philadelphia. They were Recently he was appointed associate at NIH from 1962 to 1964, is Spencer both honored for developing rests and a dean for program development at the professor of medical sciences and vaccine to identify and protect humans University of Wisconsin Medical chairman of the department of medi exposed ro the hepatitis B virus. School. He also has been named the cine at the University of Alabama at Virginia Wartawa Bascom professor in Binningham. He received at the 1993 Michael Brown, who was at NCI cancer research by the Board of Ann ual Session of the American from 1972 to 1979, is now a vice presi Regents. This professorship was estab dent with R.0.W. Sciences, Inc. The lished to advance the quality of cancer company is seeking doctoral level med research and patienr care within rhe ical research consultanrs wilh a record medical school by supporting a faculty of at least l 0 years of research and pub member. lication, to support public and private sector research programs for new med Dr. Mark Davis, a posrdoctoraJ and ical interventions including drugs. stafffell ow at NIH from 1980 to I 983, devices, and medical technologies. is professor of microbiology and Expertise is needed in clinical trials immunology and a Howard Hughes research, biostatistics, regulatory Medical Insrin1te investigator at aJfairs, medical affairs, epidemiology, Stanford University. He was recently outcomes research, and phannacoeco elected to the Nati.onal Academy of nomics. Please contact Brown at (30 I) Sciences. 294-55 l l. Dr. Vincent DeVita, Jr., ninth direc Virginia Schroeder Burnham, who tor of NCI from 1981 to 1988, was has been a consultant and member of named director of the Yale University various advisory councils and commit Comprehensive Cancer Center. He tees at NIH. is now a writer and consul- (Comi1111ed on nex1 page)
9 N I H A A U P D A T E
(Co11ti1111edfro111 previous page) fessor of medicine, University of 1953 and then worked in several insti leaves Memorial Sloan-Kettering Kentucky College of Medicine. tutes at NIH, retired as professor emeri Cancer Center, New York, where he tus in 1985 after 8 years at Johns Carl A. Fretts, who was director of Hopkins School of Hygiene 10 SUMMER 1 9 9 3 Treatment was also elected to the board of direc from 197 J-73 tors of the American Association for and then 1979 Cancer Research. 81, is now back at NIH as William A. Millar Il, who worked a senior in the Marine Hospital phannacy as a investigator in resident and a sraff pharmacist from the Clinical 1959- 1960, and from 1960-62 as a staff Investigations pharmacist at NCl in U1e PHS hospital Branch, NCl, in Baltimore, is now CEO/president of with responsi PRxN in Ledyard, Conn. PRxN is a bil ity for managed care network providing em clinical trials ployers and groups with comprehensive in central ner prescription programs. It is an enter vous system prise owned by the Masantucket Pequot and GI tract lndian Tribe in Connecticut. The oper tumors. ation is located at Mashantucket. one of Rosen. acting Cl inical Center director the oldest continuously occupied reser (above). Dr. Thomas E. Malone, former vations in the United Stares. depury director of NU-I and longtime Dr. H. Ronald Kaback, a senior NIH employee. has retired from his lat Dr. Stephen R. Max, who was a investi garor at the National Heart est job as vice president for biomedical guest worker/postdoctoral fellow at Institute from 1964 to 1968, who is a research at the American Association NINDS from 1968 to 1970. reports that professor at the Uni versit y of of Medical Colleges. He came to the he is now dean of the graduate school California, Los Angeles and the association in 1988 from a position as Howard Hughes Medical lnsritute. was associate vice chancellor for research at awarded. with Dr. Peter C. Nowell. the the University of Maryland Graduate 3M 1993 Life Science Award. The School ( 1986- 1988). In his years with award was given to the pair at the AAMC he has directed a broad spec Experimental Biology '93 meeting in trum of research-related programs and New Orleans in March. Kaback was activities including addressing funding, selected because his "contributions dur manpower. animal welfare, technology ing the past three decades have been transfer, uni versity-industry relations cent ml to the development of srudies of and scientific integrity, staffing the transport and energy tTansduction in Advisory Panel on Biomedical biological membranes at the molecular Research and tracking the NIH strare level. .. The work from Ka back· s gic plan. Recently he was elected to laboratory has been seuing the pace and the board of directors of NIHAA. style for most of the work done in gra dient coupled transport during the past Dr. John Minna, former chief, NCL three decades. Following the presenta Navy Medical Oncology Branch, tion of the award. he gave a lecture on Division of Cancer Treatment, NCI, is "Molecular Biology of Membrane now director of the new Harold C. Transport: The Ecstasy and the Simmons Cancer Center at the Agony." Uni versity of Texas Southwestern and vice president for research at Medical Center. Dallas. Recendy he Hahnemann University. Philadelphia, Dr. Richard S. Kaplan, formerly received the C. Chester Stock Awa rd at as we ll as professor of biological chem clini cal associate and $enior inves ti ga the Memorial Sloan-Kettering CH ncer istry and neurology. tor at NCI in the Di vision of Cancer Center's academic convocation. He (Continued 0 11 next page) 11 N I H A A UPDATE (Co111in11edfrom prel'ious page) and appreciation of the problems these whatever the awardee wishes. " I don ·1 Dr. Robert K. O ldham, who was countries face. not the least of which is know what I'm going to do with it," director of the Biological Response child health. The response, to elate, of said Silbergelcl. " I had just come back Modifiers Program and associate direc th e United States has been gratifying from an aggravating meeting a1 the tor in the Division of Cancer Treatment , and, I hope. will be mutually beneficial EPA when I got the call. It's kind of NCI. from 1980 to 1984, is director of to all concerned.'' overwhelming. My first reaction was. the Biological Therapy Institute in ·This is my daughter'-she·s 12. and Franklin, Tenn. Recently he wrote a Dr. Kar l Piez, a scientist and chief of called me once in a strange voice, book on BioErhics Opportunities. Risks the Laboratory of Biochemistry, NIDR. telling me I 'd won the louery." c111d Ethics: The Privatiza1io11 of from 1952 ro 1982, has returned 10 the Cancer Research. Washing1on area from Palo Alto where Dr. John H. Tuohy, who was a he was vice president for research at senior investigator and chief in the solid Dr. Georges Peters, who was at Celtrix Ph armaceutica ls. Collagen Corp. tumor chemotherapy service ror NCI at NIH as a clinical associate from 1966 From 1991 10 1993. he was a scholar the Clinical Center from 1953 to 1956. to 1968, is now in th e division of pedi in-residence. FIC. Now he is a profes is now a senior consultant in internal atrics/infectious diseases at Rhode sor in the department of biochem istry medicine al the Aimed Forces Hospital. Island Hospital, Providence. He writes and molecular biology at Jefferson King Abdulaziz airbase. Dhahran, that he has "just returned from a two Medical College, Thomas Jefferson Saudi Arabia and clinical associate pro week professional visit on behalf of rhe Universicy in Philadelphia. Currently. fessor of medicine. King Faisal Univer U.S. Agency for International Develop he is also president of the Foundation sity School or Medicine and Medical ment 10 two newly founded Central for Advanced Education in the Sciences. Sciences. Dammam. Saudi Arabia. In Asian republics. Uzbekistan and Kyr sending in his membership application gyzstan, in rhe former Soviet Union. Dr. Ellen K. Silbergeld, who was at he wanted it 10 "affinn my affection The visit was to advise those govern N INCDS from 1975-8 1. and NICHD for, and loyalty to our alma muter. " ments on childhood immunizations from 1982-84. is now professor at the (remember chose diseases we grew up University or Maryland Medical School Dr. I. Bernard Weinstein, a clinical with but our children did not-measles. and chief t0xics scientist. Environmen associate in the metabolism service at polio. diphtheria, etc.). This trip was tal Defense Fund. She is the recipient NCI from 1957 to 1959, is now director fruitful, albeit challenging, in many of a MacArthur Foundation grant of of the Columbia-Presbyterian Cancer respects, particularly my education in $290,000. The prize may be used for Center. It is th e new name of the Columbia University Comprehensive Cancer Center. T his change refl ects ··the true diversity of the cancer center and its close working relationships with various units or Columbia University and Presbyterian ... he said. Dr. Samuel W ells, a clinica l associ ate in the Surgery Branch, NCI, 1964 66, is chairman. department of surgery, Washington University School of Medi cine. He is a member of the National Cancer Advisory Board and recently became president of the Society of Surgical Oncology. Dr. Donald Morron. an NIHAA alumni member. and medical director ofJohn Wayne Dr. Georges Peters (r) shaking handswith the deputy minister of health, Republic of Cancer Institute. completed his tem1 as Uzbekustan, after presenting him with a copy of the American Academy of Pediatrics Red president and is now chaimian of the Book on Dec. 10, 1992 In Tashkent. executive council. 12 SUMME R 1 9 9 3 Dr . Nancy S. W exler , who was a Attention health scientist administrator with NIHAA wants to hear from its members. Please type or print your note for a future NINOS from 1976 to 1983 . is professor issue and mail it to Update at 9101 Old Georgetown Rd. , Bethesda, Md. 20814 of clinical neuropsychology in rhe departments of neurology and psych iarry of 1he College of Physicians and Sur Name geons. Columbia Universi1y. She is also Home Phone the president of the I lcreditary Disease Foundation. For the Human Genome Home address Leclures. she delivered on May 20 a tu lk entitled, "Long Day's Journey into Night: The Search f'o r 1he 1-lunlington's News, include dates/position at NIH and photo if possible Disease Gene:· about the long but recently concl uded search for rhe Huntingron's disease gene. Dr. Peter Wiernik, associate director in the Division or Cancer Treatment from 1966 to 1982. and now al A lbert Suggestions for newsletter Einstein Cancer Center. was ins1allcd as president of 1hc /\mcrican Radium Socic1y al its annual meeting in April. Suggestions for NIHAA Or. G. Donald W hedon, former dircct0r of N IADDK. has been elected a fellow of the Royal Society of Medi cine. Lac;1 October al 1hc society in London he attended 1hc celebration of the 25 th anniversary or the anglo-ameri can Royal Society of Medicine Founda tion. highlighted by a 1hrcc-day confer ence en titled ...The impact of molecular medicine on clinical practice ... 13 N I H A A UPDATE Science Research Updates in Human Genetics M urray Goldstein. ''W ith such infor mation in hand. scientists may be able NINOS Hails Discovery of Gene spinal cord that control voluntary to develop new treatments for nervous for Familial ALS movemems. A lthough patients do not system lllmors. such as drugs to mimic lose sensation or mentul alertness. they the gene's normal function." The cur Officials at I DS hailed the identi eventually become physically disabled. rent study was conducted by INDS fication of a gene associated with the have difficulty speaking and swallow grantee Dr. James Gusella at Massa familial form of ALS (Lou Gehrig's ing. and may succumb to in fec tions. chusetts General Hospital. Dr. Roswell disease). " This discovery is extremely particularly pneumonia. Death usually Eldridge. now-retired I DS scientist. important because it marks the first occurs in about 5 years. Currently. and 18 other collaborators. identificat ion of a specific gene for a there is no cure or preventive measure: ncurodegenerative disease of adull however. several therapeutic approach life.'' said Dr. Carl M. Leventhal. direc es are under investigation Scientists Link Fatal Disorder to tor of the NINOS program that con Chromosome 18 tri buted to support for the research reported in the Mar. 3 issue of Nature. NINOS Grantees Identify Scientists at I DS have linked a " It also suggests a likely mechanism for NF2 Gene deadly brain disorder, called Niemann the damage to nerve cells in familial Pick type C disease. to a small region ALS and. possibly. other brain disor Scientists have identified a gene that of human chromosome 18. These lind ders.·· normally prevents development of ings. reported in the Pron•edings of the In the study, Dr. Daniel R. Rosen of tumors and, when damaged, causes an Nario11al Academy r~f Sciences. may M m;sachusetts General 1l ospirnl und n inheri1ed disorder with mult iple bruin eventually lead LO improved diagnosis team of international investigator:. and spinal cord tumors called neurofi and treatment for the inherited disorder showed that mutations in a gene that bromatosis type 2 (NF2). T heir res ults and yield new insight into the metabo codes for the enzyme superoxicle dis appeared in the Mar. 12 issue of Cell. lism or cholesterol inside the body's mutase I (SOD I) were tightly linked to .. Right off the bat. this advance will cells. the occurrence of ALS among 13 fami improve diagnosis for NF2 patients. ·These findings represelll a critical lies. SOD I works inside cells to help With further research, it will help sci step forward in identifying the faulty neutra lize the toxic effects or free radi entists uncover the biological basis of gene that causes Niemann-Pick type C cals. which are highly reactive mole this disorder and should lead to the disease. Once that is accomplished. we cules that can trigger destructive chem development of specific treatments,'' will be poised to develop specific, ica l chain reactions. Excess levels of said Dr. Philip Sheridan, chief of the effective treatment for this devastating free radicals have been suggested as a Developmental Neurology Branch. disorder:· said Dr. Ro coe Brady. chief cause of tissue damage in Parkinson's NINDS. which partly funded the study. of NINDS's Developmental and disease. A lzheimer's disease. trauma, .. Furthermore. this discovery offers a Metabolic Neurology B ranch. stroke. and other neurological diseases. valuable clue about the causes of brain About 200 to 300 Americans have ··11 is intriguing that the gene the ~ci and nervous sys tem tumors in the popu iemann-Pick type C disease, in which en tists have identified plays a vital role lation at large.'' faulty metabolism of choles terol within in controlling metabolism of free radi Each year, more than 40.000 cells leads to abnormal cholesterol cals,'' Leventhal said. ·These findings Americans develop tumors in the brajn buildup in the brain. liver. and spl een. should stimulate additional research to and spinal cord. NF2. currently treated Affected children typically develop define th e role or free rad icals in ALS by managing the tumors as th ey occur, normally until school age. then begin to and 01her brain disorders." affects one of every 40.000 children regress. The lirst symptoms of the d1~ As many as 30.000 Americans suffer born in the United States. ease can be subtle. such as declining from ALS. Most cases of the disease ··Understanding how a fau lty NF2 performance in school, but as the dis occur sporadically: however, about 5 gene leads to excessive cell growth will ease progresses. brain damage worsens. percent to I 0 perce111 arc familial. ALS teach us about the basic biology of causing progressive dementia and strikes in midlife and causes degenera tumors in the brain and elsewhere in motor problems. including difficulty tion of th e nerve cells in th e brain and the body." said N INDS direc tor Dr. with walking. talking, and swallowing. 14 S U MME R 1 9 9 3 Most patienrs die before they reach the " By locating the gene most likely tain patients with ALD. the oil does not age of 20. responsible for ALO, science has seem to ameliorate more severe fonns "I have high hopes that identifying achieved a major step forward in its of the disease. and is not a cure for 1he disease gene for Niemann-Pick C efforts to understand this debiti tating ALD. wi ll help us learn more about how cho disease:' said Dr. Duane Alexander. In this study, investigators used a lesierol is processed inside cells of the NICHD director. "This finding offers technique known as positional cloning brain and other organs." said Dr. Peter hope to all those who suffer from ALO. to identify a gene that was partially G. Pentchev, an NINOS biochemist as well as their families." deleted in six out of 85 patienrs with who has been conducting l\'iemann ALO is an X-linked genetic disorder ALO. In the nonnal population, no Pick C research for more than a decade. that is passed on by females. but affects deletions in this gene are found. ''This informalion, in turn, could offer onl y males. The disease is relatively Although investigators originall y sus vital insights into how this process goes rare, affecting approximately one out of pected that the gene would code for an awry not only in this disorder, but also every 20.000 males. It causes the enzyme. known as VLCFA CoA. that in such common killers as heart djsease breakdown of a fatty substance, known for some time has been thought to be and stroke.·· as myelin, that forms an insulating bar impUcated in ALO, it actually codes for In the current study, a collaborati ve rier around nerve fibers. a different kind of protein. This protein team including scientists at NIMH ana The basic mechanism underl ying is one of a family of proteins (ATP lyzed DNA samples from 12 affected ALO involves a defective gene located binding proteins) that transport mole fami lies and identified a small region on the X chromosome, which ultimate cules, including proteins. across cell on chromosome 18 most likely to house ly leads to an excess of very long-chain membranes. The abnormal protein the recessive disease gene. "We've fatty acids (VLCFA). Nonnally, underlying cystic fibrosis. which is not drastically reduced the size of the hunr VLCFA are metabolically broken down related to ALO. is p~m of this protein for this gene." Pentchev said. ''The in peroxisomes. which are enzyme-con fam il y. region we've identified covers less than taining cell structures that produce and With the discovery of the gene most 3 percent of chromosome 18. and with break down hydrogen peroxide. Jn likely responsible for ALO, research in a little luck, we should identify the pre people with ALD. however. this this area has taken a giant stride for cise gene soon . ., process is impaired. resulting in exces ward. If indeed this is the correct Scientists will then be ready to deter sive amounts of VLCFA. This build up gene-and investigators are virtually mine the corresponding protein defect damages the myelin in a process known certain that it is-a number of avenues and to devise new treatments, including as demyelination. which occurs when have suddenly opened up. according to drugs designed to intervene in the dis the myelin sheath surrounding nerve NICHD grantee Dr. Hugo Moser, ease process and protein or gene cells is progressively destroyed. In director of the Kennedy Krieger replacemenr therapy, Brady added. addition. ALO results in progressive Jnstirute's Center for Research on mental deterioration. blindness, and Menral Retardation and Related adrenal atrophy. This is the disease in Aspects of Human Development. and ALO Gene Probably Found NICHD its most severe fom1, however, which one of the srudy · s coauthors. Grantees Report occurs when onset is early in child First, knowing the location of the hood. Ln adults. ALO may cause gene will enable doctors to identi fy NICHD has announced that institute milder symptoms. indjviduals who have the gene, either in supported scientists have located the The disease was recently brought to the carrier or active states. Currently. gene that codes for adrenoleukodystro public attention with the release of the tests used to identify ALO carriers are phy (ALO). a genetic disease character movie Loren:o's Oil. a dramatic not LOO percent accurate. Second, with ized by progressive deterioration of accounr of one family's search for a further study it will enable scientists to cells in the central nervous system. cure for their son suffering from ALO. understand how the biochemical abnor This hi ghly significant find ing may Loreozo's oil, a mixture of glyceryl tri mality leads to the neurological deficit. eventually pave the way for an inten oleate and glyceryl trierucate oils, nor "One of the very great puzzles is that sive effort to test the possibility of gene malizes the levels of VLCFA in plas only half of the patients with the bio- therapy for ALO. ma. Willie it may be beneficial to cer- (Co111in11ed 011 ne.w page) 15 N I H A A U P D A T E (Co111i11 11ed fro111 previous page) said. "Tile region 1hat we've discovered genetic factor was involved. Further chemical deficit ge1 the severe disease. represents a significant variation in the more. the maternal Link sugges1ed 1ha1 and 1he 01her half do not." Moser human gene1ic repertoire. I f the gene homosexuality might be associated explained. " Identifying 1he gene will itself can be isolated. then it will be with the X chromosome. which is the permit us to understand how the disease important to understand how it interacts sex-linked chromosome that men inher process comes about.·· with Olher genes. the brain. and the it only from their mothers. Ultimately. the finding may lead to environment 10 innuence a trait as com Explicit evidence for a genetic link gene therapy for A LO. The investiga- plex and variable as human sexuality."' was obtained by studying the X chro 1ors now are trying to develop a trans Hamer is with NCI and conducted ma. ome DNA of' 40 pairs of gay bro1h genic animal model. which is a normal the srudy as part of th e insLitute's eff'or1 ers. The scien tists used a technique animal inl'o which a defec1ive gene has to identify genetic factors involved in called linkage mapping to search for been introduced. If successful. such a cancers that are frequently found in gay patterns of similarity in the genetic model would hold enormous promise men infected with 1he AIDS virus. infom1a1ion of related individuals. for effons to develop an effective gene Harner and colleagues studied the Thiny-threc of the gay sibling pair~ had or alternative therapy such as drug family histories or 11 4 gay men and coinherited gene1ic markers in 1he same treatment. found that their bro1hers, ma1ernal chromosome region called Xq28. sug The immediate next step is to obtain uncles. and maternal male cousins were gesting that 65 percent of' the families proof th at this is the correc1 gene by more likely 10 be homosexual 1han studied were transmitting a gene for adding it to cells in culture that lack it would be expected among the general homosexual orientation. to sec if the biochemical defect present male population. In some families, gay "The statis1ical significance of the in ALO is corrected. relatives could be traced back for three results was better than 99 percent. generati ons. Because the homosexual which means 1hat the possibility of uncles and male cousins of the gay sub obtaining our findings by chance is New Study Finds Genetic Link to jects were raised in different house extremely unlikely," said Hamer. Homosexuality holds, the scientists hypothesized that a However. he noted that replication on A new study has found a correlatfon between a specific region of the X chromosome and male homosexuality. The finding represents new evidence thm sexual orientation may be influ enced by heredity. The study conducted by NLH scien tists titled "'A Linkage Between DNA M arkers on the X Chromosome and Male Sexual Orientation" was reported in 1he July 16 issue of Science. The authors are Dr. Dean 1-1 . Hamer. Stella Hu, Dr. V ictoria L. Magnuson. Dr. Nan Hu, and Dr. Angela M.L. Pattatucci. By analyzing the inheri1ance of genetic markers in pairs of homosexual brothers, the scientists localized the region related to sexual ori entation to a minute segment of the human genome. However, a specific gene has not yet been isolated. Hamer, chief author of the study, Or. De an H. Hamer 16 SUMMER 1 9 9 3 Scholars (co111in11ed ji·o111 p. I ) selected individuals to be invited. an independent population of fami lies from all over the world to NIH in order Sufficient funds were available in the will be necessary to confirm the results. to conduct ·'advanced studies" in the first budget for seven invitations to be The scientists do not know why health sciences. The center was also issued. The first scholar. nominated by seven of the 40 pairs of gay brothers designated co administer international Dr. Marshall Nirenberg in the fall of did not coinherit the Xq28 genetic fellowshjp programs already in exis 1969. was Dr. Uriel Linauer. from the marker. Hamer postulated that these tence and to take over cenain interna Weizmann Institute of Science in Lsrael. gay men may have inherited other tional responsibilities from 1he Office He was followed by Ors. Manubu Sasa genes that are associated with homo of International Research (OIR), which (Japan). John Edsall (USA). Jeffries sexuality. or they might have been had been part of the NIH director's Wyman (USA). Isaac Berenblum innuenced by environmental factors or office. T he scholars program was seen (I srael). Torsten Teorell (Sweden). life experiences. as a new central focus of 1he FrC pro Daniel Bovet (Italy). Ragnar Grnnit ''Given the intricacies or human grams. (Sweden). Frank Fenner (Australia) and behavior. ii is not surprising that a sin Prior to institu1ion of the program Percy Garnham (UK ). to name a few of gle genetic locus I regionl fails to there was much discussion about the the early parc icipants in the program. account for all of the variation seen in meaning of advanced swdy; whether or From the beginning the program has the study group:· said Hamer. "What not the program should have an extra been closely associated w ith the intra is remarkable is that we can account for mural component: should the program mural programs of the instiru1es and at least some of the inherited variability be devoted 10 particular problems and divisions of NIH. All the early schol wi th a fa ir degree of statistical confi how th e scholars should relate to NIH ars were nominated by NTH staff and dence.'' staff. The need for such a program was were associated with laboratories on The scientists are also studying the strongly felt by the leaders of NIH and campus where they were treated as families or lesbians. Preliminary results by th en assistant secre1<1 ry for health of members of the;:ir 11 011 1i11a1or·s l lished from which tJ1e FIC director (Comi11 11ed 011 next page) 17 SUMMER 1 9 9 3 "Thank you NIH" Reminiscences of a Fogarty Scholar-in-Residence (1987 to 1989) By Dr. f/erherr G11tfre1111d The award of a Fogart y scholarship is an honor, which is accompanied by remarkably few responsibilities. The candidate is proposed, assessed and then offered 12 monlhs of hospitali1y at one of the world's finest inslitutions for biomedical research. When l was invit ed to come 10 NIH as a Fogarty schol ar-in-residence I gave some thought to the best way to use this opportunity. The title "scholar" conjured up ideas in my mind. I remembered my own inter pretation of the distinciion between scholarship and research. drawn in a le11er to British universi ties by a seoior Dr. Gutlreund, emeritus professor of physical biochemistry, University of Bristol School of academic administrator. Scholarship is Medical Sciences, Bristol , UK, is shown in a recent photo at the C & O canal on the using ex isting knowledge for a synthe Maryland side of Great Falls park. sis and appraisal. while resea rch is the acquisition of new knowledge. The lat those who spend all their time in their cult to persuade some or the most inter ter is not restricted to new fac ts, it office in the Stone House. with visits to esting scholars to come to discussions clearly also includes the explanation of the library, and others who are hardly at lunch time or in the late afternoon fact s. ever seen there except to collect their because they were 100 busy in the labo When Mary and I arrived in mail. The lauer could just as well have rntory. Even the " regular" dinners Bethesda in January 1987, with two come under the visiting scientist became very ''irregular.'' severe snow storms imminent. I already scheme ro do a specific piece of collab I was originally asked by the head of knew the area and NIH campus well. orative laboratory research. a section whether I wanted to spend My wife was also familiar with the I grew up in the very gregarious some rime in Bethesda 10 collaborate North American way of life and soon atmosphere of academic life in with him on a project close to both our go1 involved in an interesting research Cambridge during the postwar years. hearts. It was for this venture that he project with deut' children at Gallaudet A lthough I managed without this at proposed me 10 the Fogarty University. We had great advantages various times since, rh e elegan t sur lntermuional Center for a scholarship. over some of my fo llow scholars who roundings of Stone House made me By the time I was offered the scholar had a cultural shock, no U.S. money feel that some effort should be made ship both my host and I had different and wives who had language difficul towards its use as an intellectual center. and divergent interest!\. This conlirms ties. Although Lhe delightful small Peter Condliffe, who was head of the the conclusion that Fogart y scholars house we rent ed turned out 1101 to be scholars program at the time, had all shou ld not be chosen for 100 specific a entirely weatherprool', we setl'led in the social and intellectual a1 tribu1·es of a reason, and rhat assured success of the quick ly. ''head of a small Oxbridge house." time spent at NIH depends on the I soon round out th at different schol This was only marginally successful scholars having wide interests. ars used their time in Bethesda in dif since he did not have the final word in I was in the fort unate position that ferent ways. The two extremes are the selection of scholars. It was diffi- (Co111i1111ed 0111/ie next pal{e) 19 N I H A A UPDATE Investment For Humanity and relates 10 that central guiding mis sion. Woven throughout LJ1is plan is a Ediwr's Nme: On June 30. 1993. Or. Bernadine Healy fi rm recognition of I) a commitment to resigned as NII-I director and returned 10 the Cleveland basic and clinical research as the means Clinic Foundation. One of her great areas of interest was of expanding our knowledge base: 2) the development of a strategic plan for N II-I . Here is the the importance of nurruring and sus preface she wrote for .. Investment for Hum.anity: A taining a robust and varied human capi Stra tegic Vision for th e National Inst itutes of Health." ial base; and 3) the need for sophis1ica1- ed infras1ruc1u re to accomplish bo1h. ·· . .. w i11ter l'e 11e. el'en br ieJly, be1111ee11 m11·f ello11' crea- A lthough the specific initiatives may 111n1,1· and 1/J eir suffering or deallt. is our 1110.1·1 a11t!temic change as science and 1he needs of amwer 10 1/te q11es1io11 of011r !t1111 w 11 i1y." society change, N IH 's fundamental Howard Sack ler, American playwrig/11 mission and purpose will remain The National Institutes of Health was ported institutions nationwicle- partici immutable .... established more than a century ago to paic in this process. The plan is a The benefits of that investment improve and safeguard the health or vision. not a blueprint: it is a frame extend also to our Nation's economy. every American. Today. N IH contin work. not a manual of operations; it is a The biotechnology, bioengineering. and ues to pursue science for the sake of beginning, not an end. It defines an pharmaceutical industries (and rela1ed each man. woman, and child in 1hc N IH flexible enough 10 respond to soci Ii fe-scicnce-based corporal ions) are United Stales, reflec ting 1he central ety's changing health care needs and increasingly import ant to improving the tenet of our democratic society: 1hc dynamic eno11 eh tn open ever more Nation's economy-cre;1ting new j obs. belief in th e value and sanctity of the promising frontiers of' rundamemal technologies, products, and services. In individual. Science for the sake of the research. A lthough a new underraking many regions of the country, biomed citizen is an idea rhat has grown up for N LH. the Strategic Plan does not ical science is a great catalyst for the with America. Thus. it is no accident sever Lies with the past. Rather, it creation of skilled, high-level jobs and that the United States. the world's builds on past accomplishments, orga is responsible for considerable econom greatest democracy. has created the nizational strengths. and approaches of ic productivity. NIH is the engine LJrnt world's greatest biomedical research proven value. This document also drives this emerging "bioeconomy:" an establishment. dedicated IO serving not affirms our commitment to the individ economy thtll will lead to better health, th e stale, but the individuals who make uals who are the NIH: they are th e lower health care coses, and sustained up 1he state .... source of our creati ve advances, pri economic growth. The NIH Strategic NI 1-1 ·s intellectual capi ta l base and marily through their insights, initia Plan will help ensure that our Nalion scien ti fic reso urces are devoted to tives, and individual talent. remains at the forefront of the burgeon addressing the most challenging. urgent l 11l'es1me111 for H11ma11i1y is predi ing economy. public health and biomedical questions cated upon the need to create an envi /111 •e.\'//11em for Humanity pledges the of our time. The growing complexity ronment that promotes creativity on the NIH community to address the oppor or these challenges-ranging from part of individual scientists. The pur tunities. challenges, and needs for the reducing the suffering from heart disease sui t of research opportunities that are future with vigor. dedica tion. and and cancer to finding a cure for A lOS closely aligned with our Nation's integrity. In 1urn, it also calls for a reci couplcd with lhe urgem neecl to manage health goals and our citizens· individ procal commitment from this Nation's prudently the U.S. taxpayers· $ 10 bil ual needs is also centra l to our plan. By citizens and their elected represenla lion in ves tmcm in N IH. requires th at we focusing Nll-l 's organizalional thinking, ri ves, not only lo sustain. but also to think very carefu lly about our fut ure. the Strategic Plan articulates how our enhance th e stre ngth and vita lity of this T hat is precisely what occurred as we community defines its priorities for un ique institution-this republic of sci embarked upon our strategic planning investment. ence-they have created and nurtured effort. The leadership of NIH along The Strategic Plan starts with our over many years. For NIH to fulfill its with some 2.000 representatives of the statemenL of mission - science in p11r mission of pursuing science for the scienti fic community-from our intra .rni1 of k11011'/edge 10 i111prol'e /111111011 sake of each citizen, our vital enterprise mural commun i1 y and from N II-I-sup- ltea/1/t. A ll th at follows derives from must be a national priori1y. 22 SUMMER 1 9 9 3 research 10 define 1he sites and mechanism damcn1al co111 ribu1ions 10 our understanding NIH Notes -· February of action of toxicanls thal ahcr 1he male of' cancer e1iology and prevention" ... Dr. reproductive system. especially 1he tes1es ... Lvnn Gerber, chief. Dcpartmenl of 1993 to July 1993 Dr. Gio"anni Cizza of 1he Dcvelopmemal R~habilitation Medicine. Clinical Center. Endocrinology Branch. NICHD. has received has received 1he Public Health Service AWARDS AND HONORS 1wo awards-the 1992 AGS/Merck Sharp award for exceptional achievement in & Dohme New lnvestil!alOr Award from the orphan product:. development. The award Dr. Seymour Benzer, an NIGMS grantee American Geriatric S~iety scientific pro cited her innovaiive and creative design of and 1hc James G. Roswell professor of neu grams committee. and the Henry Christian braces for children wi1h osteogenesis impcr roscience al 1he California lns1itu1e of Award from the American Federa1ion for fec1a. The devices allow children wi1h bri1- Technology, was recently awarded the Clinical Research. Bolh awards were given 1le bone disease 10 be more mobile and Cral'oord Prize for his work on genetic 10 him for his work in aging research ... Dr. aclive ... Or. Thomas Glynn. ac1ing associ mutmi ons 1ha1 a!Tccl fruit ny behavior. He Francis S. Collins. newly named director ate direcior of 1he Cancer Control Science wi ll share the $338,000 award wilh a Bri ti sh of the Nati onal Cen1er for Hum an Genome Program and chief of the Cancer Prevention scic 111is1 who is also siudying behavioral Research, has been elecied to the Na1ional and~Comrol Ex1r:imural Research Branch. gcnc1ics. The winners are chosen by the Academy of Sciences ... Dr.. f 11cqucline N. recen1ly received the Joseph W. Cullen Swedish Academy of Sciences. which also Crawley. chief of the unil on behavioral Memorial Award. which memorializes the selccls 1hc winners of Nobel Prizes in sci neurophannacology within 1 !Ml-l's former depu1y director of the Division of ence ... Or. .lay A. llerzofsky, chief of the Experimental Therapcuiic~ Branch. deliv Cancer Prevention and Comrol and program molecular imn;unogcneiics and vaccine ered on May 4 1he 20th Malhi Ide Solowey coordinator for 1 Crs Smoking Tobacco research seciion. Metabolism Branch. Leciure Award in the euroscicnces. She and Cancer Program from 1982 10 1989. a1 Division of Cancer Biology. Diagnosis, and presented the results of her research in a 1he annual meeting of the American Socic1y Cemers. NC I, has been elected prcsidenl of leciure titled. "Coexis1encc or Neuropep- for Prcvcmive On~ology. Glynn has con 1he America n Socie1y for Clinical 1ides wi1h 'Classical' Neuro1ransmi 11ers: sulted on tobacco issues with a wide varie1y lnves1iga1i on ... Or. Roscoe 0. Brady, chief Func 1i onal Studies Relevanl 10 Neuropsych of interna1ional and domestic organizations of NlNDs·s Developmemal and Metabolic intric Disorders .. ... Dr. Anthony S. Fauci, ... Dr. Steve Gordon, chief of the Muscu lo Neurology Branch, recently received the NIAID director, was the recipient or several skeleial Diseases Branch. NIAMS, recen1ly 1992 Warren Alpert Founda1ion Prize for honors and awards: he was presen1ecl by 1he received an award from 1he American his 30 years of groundbreaking research in American Medical Association ils Dr. Sociely for Bone and Mineral Research "in 1he area or lipid s1oragc disorder . I-l e has Nathan Davis Award for Ou1standing graieful appreciation of his exemplary guid dclined much of whal is known or lhC bio Public Service. and recenily received hon ance and service in direc1ing research up chcmis1ry of 1his group of disorders and has orary dociorates from 1hc Medical College pon in the field of bone and miner.ii metab Mimul:ued invcs1iga1ion across the field of or Wisconsin. Ba1es College in Maine and olism" ... Dr. Florence Haseltine, director biomedical research ... Or. Samuel Broder, Bard College in New York. In addition. he of 1c 1-m·s Center for Populaiion Research. NCI direcior. was clec1ed 10 the Naiional presented c'Ommence111en1 addresses al the was elec1ecl 10 1he 1a1ional Academy of Academy of Sciences' Institute of Medicine Medical College of Wisconsin. Bard and Sciences· lns1i1u1 e or Medicine ... Dr. ... Dr. Bcrn11rd Brooks, head of DCRT's Stan ford Universi1y School of Medicine ... Anne-Marie Hccgaard, a visiting fell ow in molecular graphics and simulati on secti on, .Julie F. Foley of 1he Experime111al 1he Bone Research Branch ar NIDR. is 1he wns l1011ored recently as the guest speaker al Toxicology Branch. NIEMS, received the winnerofihe Merck Sharp & Dohme Young Howard Universi1y's 271h amiual Percy L. Diamond Cover Meril Awnrd for a manu lnves1iga1or Award from 1hc American Julion Memorial Leeiure. Following hi s scripl published in 1he Jounuil of Socic1y for Bone and Mineral Research. 1alk. "Molecular Dynamics for Problems in J-Ji.wotcc/1110/ogy. She was 1he lead author She was honored for an abstract she wrote S1rnc1ural Biology." he wa~ presented with on a p;1pcr that no1 only demons1ra1ed origi on biglycan. ;1 proiein found in bone. and iii. a special commemora1ivc plaque by nulity but was of widespread imercst to the possible role in the development of bone Howard's chap1er of the Sigma Xi Research journars readers ... Dr. .J oseph P. abnom1ali1ies al>sociatcd with Tumer'i. and Socie1y. which sponsored the lcc1ure ... Dr. Frnumeni, Jr., associaie dircc1or for epi triple-X-syndromci; ... Dr. Ada Sue Debo rah Carr>cr, a biologist wi1h the demiology and bios1a1istics in NCrs Hinshaw, director of the National lnstilute catnrac1 sec1 io11 of NEJ's Labora1ory of Division of Cancer Eiiology. was honored or Nursing Research. recently was named Mechanism of Ocular Disease, recently with 1wo awards: he received from 1he Heal1h Leader of the Year by the received 1hc Alcon Award for ou1s1anding American Socie1y of Preven1i ve Oncology Commissioned Officers Associmion of the con1ributions 10 vision research. The work i1 s Disiinguished Achievement Award for U.S. Public 1-l eahh Service. Esiablished in for which she received 1he Alcon award is ''his ou1siandin2 achievemen1 in cancer prc 1987. the award recognizes individuals who 1i1 lcd 1he "Role of 1he Polyol Paihway in veniion and co1~1ro1:· and he also was 1he have made no1able con1ribu 1ions to 1he Diabc1ic Complicaiions" ... Dr. Robert recipient of the American Associa1ion for heahh of 1he nation. She received lhe <1ward Chapin. u toxicologis1 in the reproductive Cancer Research's newesl award. the Ameri al 1he USPl-IS Profc~ s ional Associaiion·s 1oxicology group at NIEHS. has been cnn Cancer Society Award for Research 281h Annual Mce1ing in Scousdale. Ariz .. i.clcc1cd as 1he Young Andrologis1 of the Excellence in Cancer Epidemiology and where she presented a taJI.. on .. Quality of Year for 1993 by the American Society C>f Prevention. for .. his uns1inting cledicaiion 10 Life: A ursing Focus" ... Dr. Peter M. Andrology. He was honored for his cancer epidemiology which has yielded fun- Howley, chief of the Labora1ory of Tumor (Col/fi1111ed 011 11ex1 page) 23 N H A A UPDATE Virus Biology. NCI. has been elec1ed 10 lns1iiu1e Alumni Association. He was cited chief of IC HD"s Developmental and 1heNaiional Academy of Sciences. He left "for extraordinal)' achievement in executive Molecular Immunity Branch. was elecied to NIH in July to bccomechaimian of patholo management and personal leadership result the National Academy of Sciences· Institute gy at Harvard School of Medicine ... Or. ing in distingui shed achievements in public of Medicine ... Dr. Martin Rodbell , chief Ruth L. Kirschstein, N IGMS di rector and service·• ... Dr. David J. Lim, director or of 1he signal transduction section in NlEHS" acting Nlli di rec1or. has received from th e the division of intramural research. NI DCD. L:iboratory of Cellular and Molecular Federation of American Societies for recently received the 1992 Shambaugh Phannacology. was elected to membership Experimental Biology its 1993 Public Prize in Ciiro. Egypt. from M. Nasser in lhe American Academy of Arts and Service Award. Ki rschs1ein. who has direct Kotby. president of the Collegium Otorhino Sciences. He also recently received an hon ed NIGMS for 19 years. was honored for laryngologicum Amicitae Sacrum. He orary doc1ora1e degree from the Universi1e her .. strong leadership in the lields of basic received the award for his outslanding con de Montpellier in Montpellicr Cedex. biomedical research, research training and tributiorL~ in auditory neurobiology and France. He was honored. al the university's women·s health issues." according to oto logy. The Shambaugh Prize, established 700th anniversary celebration. for hi s con FASEB president Dr. Shu Chien. He in 1949 in honor of the prominent American ti nuing contributions to the advancement of described her leadership during her 38-year otolaryngologisl George E. Shambaugh. Sr. . biomedical research in the area of receptor federal career ~L~ bo1h a scientist and an is awarded once every two years ... Or. mechanism. and his discoveries of the role administrator as "effective. intelljgent and Douglas R. Lowy of the Laboratory of of GTP-binding proieins. 1em1ed transduc compassionate..... Dr. Ri cha rd D. Cellular Oncology. NCI. received the ers. in mediating 1he actions on cell surface Kla usner. chief of the Cell Bio logy and Wallace P. Rowe Award for Excellence in reccpiors of light. hom1ones. and a variety Metabolism Branch. NICHD, and assistant Virologic Research. He was cited for ··out of other chemical signaJ s ... Or. Anne clinical professor or medicine, USU HS, was standing and innovative contributions to the S~aman , director of the Division of elected to the National Academy of papilJomavirus field. leading to advances in Extramural Research and Training. NIEHS. Sciences ... Dr. Cla ude B. Klee, chief of the understanding of the molecular biology who graduated from Auburn University NCl's Laboratory of Biochemistry in the of bovine and human papillomaviruses and with a S.S. degree in chemistry in 1965 Division of Cancer Biology. Diagnosis. and providing a basis for prevention of infcc- wilh highest honors-the outstanding grad Centers. delivered the NIH Lec1ure on June 1ion .. ... Or. Henry Masur, chief of the ua1e in the School of Chemislry-and recip 28. She reviewed research on calcium-reg Clinical Centcr·s Critical Care Medjcine ient of the University President ·s Award. has ulated reactions. She has made intriguing Depanment. has been selected for member been honored as a distinguished alumna of discoveries about calcium-regulated cellular ship in the Association of American the school ... Dr. Michael B. Sporn, chief processes that have yielded important new Physicians. He also received the 1993 of the Laboratory of Chemoprevention. insights into the mechanisms of cellular Distinguished C linical Teacher Award from NCL was selected by the University of communica1ion ... Or. Hynda Kleinman, the NIH clinical associaies ... Dr. Karin Chicago Cancer Research Cenicr as 1he chief of the cell biology section in NIDR ·s O.B. Nelson, medical officer in 1he 1993 Simon M. Shubi12 Cancer Lecturer. Laborniory of Developmental Biology. is Neuroepidemiology Branch, Nl OS. The lectureship "rewards excellence in can the 1993 winner of the WISE Award for recently received the annual Distinguished cer research" with a cash prize and a bronze Scientific Achievement. She was honored Clinical Jnvestigator Award from 1he medal ... Dr. George F. Vande Woude, for "being the most out standing woman sci American Epilepsy Society and Milken clirec1or of NCl"s ABL-Basic Research cnt is1 in the federal government." She has Family Medical Foundation ar the society's Program at the Frederick Cancer Research been al the forefront of research on the 41h Annual Research Awards Program. and Development Center, was e lected to the structure and function of basement mem Nelson was recognized for her work. along National Academy of Scie11ces ... Dr. branes-the ex1racellular marrices that sur with Dr. Jon:is Ellenberg. chief of the Nadarajcn A. Vydeling um of the Division round all blood vessels. glands. muscles. Intramural Biomeiry and Field Studies of Research Grants· special review sec1ion and nerves. She and coworkers developed Branch. NINOS. and other colleagues. on was honored recently as the gues1 speaker at and patented a basement membrane extract neonatal febrile and nonfebrile seizure dis St. Peter's College in New Jersey. He deliv called Matrigel. which is now widely used orders in c hildren ... Or. William E. Pa ul, ered the 42nd Mendel Lecture e ntitled to culture rissues that were previously difli chief of !he Laboratory of Imm unology. ··cancer Cachcxia: The Depletion of Stored cult or impossible 10 grow in the laboratory NlAID, was elected to membership in the Fa!"' ... G ladys Whitted, an NlH small and ... Or. Patricia A. Kruk, visiting fellow in American Academy of Arts and Sciences ... disadvantaged business utilization special NIA 's Laboraiory of Molecular Genetics a1 Dr. Vivia n Pinn, director of NIH's Oflice ist. was recently honored by the ational the Gerontology Research Center. is the of Research on Women's Health. was Federation of Black Women Business wi nner of the 1992-1993 Outsianding recently honored by her alma mater. Owners at its first annual Negro History Dissertation Award from the American Wellesley College. for outstanding achieve Month Black Women Business Awards lun Association of Anatomists. She won for her ment in medicine. A 1962 graduate of the cheon. Honoring women who "have dissertat ion entitled, ''Human Ovarian coll ege, she was one or four to receive the achieved a level of independe111 economic Surface Epithelial Cell s in Culture: Chnrac Alumnae Achievement Award for 1993 ... success mani fcstecl through the owner of a terization and Matrix lnt errelaiionships·· ... Dr. Judith Ra poport, chief, Child business or who have proven to be a great Dr. Cla ude Lenfant, NHLBI director. Psychiatry Branch. NIMH. was clecled to asscl to our community:· she was recog received the Federal excclllive of the Year the National Academy of Sciences· Institute nized for her ·'excellent performance" in her Award for 1992 from the Federal Executive of Medicine ... Dr. J ohn Bennett Robbins, position at IH. 24 SUMMER 1 9 9 3 APPOINTMENTS AND branch chi ef for several mon ths prior to her for the NIH. FDA. and CDC. She plans to PERSONNEL CHANGES new appointment. The focus of the branch focus on improving the basic patent and is the control and prevention of STD's li censing services provided to the ICDs by Dr. William Ul attner has been named through a national STD program ... Dr. her office ... Dr . .la)' Moskowitz has been chief of the Viral Epidemiology Branch in Richard J. Hodes. a senior investigator and named IH deputy director for science poli the Epidemiology and Biostatistics Program. chief of the immune regulation sec~on in cy and technology transfer. He will address which is pan of NCl's Division of Cancer NC!'s Experimental l.;munology Br.inch. emerging social. legal. ethical and econom Etiology. This branch was fom1cd out of has been named director of the ational ic consequences of biomedical and behav the viral epidemiology and the family stud Institute on Aging. He succeeds acting ion1l research. and l>romote ll1e lH strate ies sections or the Environmental Epidemi gic planning process. He has served NIH ology Branch. II will continue its focus on since 1969 and was most recently N11-1 human retroviruses. HTLV and HI V. and associate director for science policy and expand where appropriate into a num ber of legislation ... Dr. Kcnji Nakamura has other areas ... Dr. Geoffrey P. Cheung assumed a posi ti on in the Grants Associates recent ly joined NCRR as a program officer Program. I-l e joined the program in Novem for the General Clinical Research Centers ber 1992. His primary research effon. con Programs. He is responsible for the admin ducted at the University of Illinois and the istration of a portfolio of GCRC gran ts ... National Center for Toxicological Research. Margarite Curtis-Farrell has been named has been in the area of tu1nor biology wi th the EEO officer for the Division of Resc Research and Technology. Before 1hc Granls Brnnch (now called 1he Division of appointment. he served as OCRT"s associ Extramural Activities). where he served as a1c director. He has been conncc1ed wi1h chief or 1he program analysis and reporting N IH"i; biomed ical computing environment section from 1963 to 1973. He firs t came to ror more than 20 years ... Dr. Susana N fH in the summer of 195 1, when NIH was Scrrutc-Sztcin has been appointed chie f" of surrounded by farms and Rockville Pike the Rheumaiic D iseases Branch. N IAMS. was a country road. He was a biologist and Prior to 1his appoin1men1. she was chief of worked in several laboratories. In June the autoimmuni1y sec1ion and a medica l 1953. he lransfcrred lO C l"s Laboratory of officer in 1he Division of" Allergy. Immuno Biology. where he worked under Or. Howard logy. and Transplan1a 1i o11. N IA IO. She will Andcrvont. He became chief of the program plan. aclm inis1er. and direct the instilutc"s analysis and reporti ng section in NCl 's ex tra mural rcsc~1rch programs in arthritis Research Grant s Branch in 1963. He has a11 d re lated scientific disciplines. She will always been a dedicated volunteer and he also pa nicipa1e wi1h the insl illltc"s na tional will continue his volunteer contributions in advisory board and other organiza1ions in retirement ... Elsie Cerulli, who has se rved developing na1ional policies. legisla1ive as reference and bibliographic services ~ec ac1ivi1ies. and overall goal:. related to the 1992. and as deputy dircc1or for extramural tion chief in the NIH Library for 1he pasl 10 lield of rhcuma1ic diseases ... Dr. W illiam research resources since 199 t . Prior to that. years or her 20-ycar federal career. hn~ ,J. Sharrock recen tly joined the N IAMS she direcicd NCR R's General Clinica l rc1ircd. She has been responsible for eollec staff :is a prognun dircc1or within the Bone Resea rch Cemers Program. which oversees tion development of I.he library's 111 a1erials, Biology and Bone D iseases Branch. He a nationwide network of 72 centers in major which includes deciding which jo11rnnls. will be managing a portfolio or gran1s in teaching hospitals in which physicians con books, and other library resources 10 obtain. basic bone research. including 1he cellular. duct research on human health. As a scien rc1ain. or remove based on library user needs molecular. and dcvclopmc111al biology of tist. Vai1L1kai1is has made significant contri and available space. Additionally. ~he has hone cell me1abolism by local and sys1emic butions 10 1he development of 1hc lin.1 spc overseen opcr:uion of the circula1inn/1,l'rvicc hormones and grow1h fac1ors. He will also ci lic pregnancy assay. For these uchicve desks. distribution of free MEDLINE access administer 1raining and career awards in rnents. she received the Clinical Raclioassay codes. the processing of compu ter sea rches. 1h esc area. He is a 1992 graduate of the N IH Socie1y·s 1980 M allinckrodt Award for and coordination of the library·s M EDLINE Grant s Associaies Program. Prior to com lnves1iga tive Rese;1rch. The pregnancy test and Gr:ucful Med training courses. Her ing to N IH, he was assis1an1 professor in 1he she developed continues to be used. It has retirement plans include moving to Bel Air. dcpartmem of biochemistry at 1hc Univer evolved into over-the-counter procluc1s ror Md .• and enjoying bird watching and walk si1y of Minnesota ... Dr. George Stone has early pregnancy dc:ec1ion and for moni1or ing ... K enneth Cooke, NEI exccu1ivc ofli reccmly joined the Grants Associates Pro ing pa1ients with lllmors developed from cer. retired recemly af1cr 32 years of gov gram. His research experience is in neuro placental tissues ... Dr. M aureen •'Jake'' ernment service. He spcn1 15 of 1hose years science and cell biology ... Dr. Margaret W ilson. an administra tive officer in the with NEI, and the remainder in other N IH Tucker has been named chief" of the Genetic Division of Cancer Tremmcni, has been instiu11es. He came to N IH in 1968 to work Epidemiology Branch. which was created appoin1ecl NCI assis tant director ror cancer in a lab a1 NCI. Shortly after his arrival, he when the Epidemiology and B ios1a1istics panel and ethics. She will also be executive became the first N IH employee to enroll in Program of NCl's Division of Cancer Etiol secretary of the President's Cancer Panel. as the inhouse N IH Management Intern ogy was reorganized. This new branch wa:. well as 1he deputy ethics counselor for NCI. Program. From there he worked at N ICHD crca1cd because of changes and advances in as a budge1 analyst. mid in 1972 accepted the field ... Or . Bcrm1dctle T yr ee has RETIREMENTS the position of" 1El"s budge1 officer. After joined the NCRR staff as a scientific review 4 years. he left NEI to become N IA ID"s administrator in 1hc Oflicc or Review. She Rachel E. Brown, head nurse of 1he surgi deputy executive ol'licer. In 1981. Cooke first came to NI 1-1 in 198 I as a staff fe llow ca l oncology unit, cancer nursing service (2 retu rned to NEI to become executive offi in N IDR. and returned as a grants associate East). re1ired in January af"ter a 40-year cer, a posi1ion he held until his retirement in in 1991 af1er working as a staff invcstiga1or nursing career, 30 or which were spen t at December 1992. His retiremen1 plans will at Howard University Cancer Center and as the Clinical Center. Her unique 1ouch was involve continuing his hobby of buying. a biochemist al 1hc Naval Medical Resea rch evidcm not only in her rclmions wi1h her restoring. and selling amiques and antique lnstiwte ... Or. Judi th Vailukaitis has been colleagues bu1 also with her patients and lighting ... .Jam es .). Doherty, a writer and appoin1ed director of" the National Cemer their fami lies. As yet. she has no special public infomrntion special ist at NCRR. f"or Research Resources. She replaces Dr. plans for her ret iremcnt. though she docs recently retired after 17 yea rs of' fcdcrul ser Robert Whitney, who res igned in September not rule out volunteer work in her CQm111u vice. He was information officer for the 1992 to accept a posit ion as deputy ~ urgco n ni1y ... Hllrry Y. Cankr, chief or NCl"s D ivision or Rescnrch Services and then general. She is a reproductive neuroen Resea rch Analysis and Evaluation Branch. NCR R from 1982 to 1992 and completed clocrinologis1 whose career combines man retired rece nt ly after 43 years of federa l ser his federal service as special assistant 10 the agerial and scicmilic expertise. She served vice. He has been RAEB chief since 1973. director of CRR. He pcrfom1cd a wide a~ acting director of NCRR ~ince September He transferred in 1960 to the Cl Research array of du1ie~. from writing and editing 26 SUMMER 1 9 9 3 newsleuer.; 10 handling media relations. counselor for the division. In 1973. she par she worked as a social science analyst in the Much of his activity was devoted to helping ticipated in the fH Upward Mobility Laboratory of Developmental Psychology. infom1 the public that research with animals Program and rctumed to college where she especially on behavior.ii stud ies \\ ith chil is essentiul and lab animals arc treated received her bachelor·s degree in social dren and 1hcir parents ... George W. humanely. His hobbies include reading and welfare and rehabilitation and psychology lllakeslee, 77. a medical instrument maker Civil War history and walking along and in 1979. She was appointed the fir.;t DRG who retired in 1975 after working in the exploring the C&O Canal ... David EEO officer in 198 1. In retirement. she Biomedical Engineering and l ns~1enta t ion Me rriman in the Division of Security plans to devote more time 10 gardening and Branch at 1IH. died May 15 at a hospital in Operations has re1i red after 32 yea rs of fed wi ll be visiting her second home in North Ormond Beach, Fla .. of complications after eral service, 27 of 1hosc spcnt ul NIH. He Carolina. She also plans to continue her heart surgery ... Gregory R. Bowman, 33. joined the police force 27 years ago when it work as a volunteer in Prince Georgc·s secrcwry for NCRR 's Bi ological Models was known as a guard force. In the pas t yea r County ... Or. Charles "Chuck" Zierdt and Materials Re,~c arch Program since its he has served as a management analys1 and Dene Zicrl, both in the clinical pa1hol creation in 1989. died or pneumonia Apr. I. work ing in DSO's adminis1ra1ive office. ogy microbiology service al 1he Clinical Aflcr a stint in the Air Force his federal For many years he worked at the animal Center, have retired. He came to 1he Clinical civil career began in 1983 when he went to facility at Poolesville and he recalled a Center in 1956. She joined the Slaff two work for the Naval Air System Command funny story from hi s days there when the years later. They married in 1967. Between as a clerk/typist. He then went on to work form pond was open to NIH empl oyees and them. they' ve published. together and sepa at Walter Recd Army Medical Center and their families for fi shing. "One Saturday. rately. 11 8 scienti fic papers. In retirement the Dcpartmem of Navy before joining Dr. Robert Marston. then the director of he will continue his hobby. restoring antique ORR in 1989. (D RR later merged with NIH. came 10 go lishing. I-l e wa~ wearing cars. Gardening. crafts. wri ting. grandchil DRS to form the current NCRR) ... Dr. old shorts. a hat. and had no identification dren. and great grandchildren will keep Dale C. Cameron, 80. a retired U.S. Public on him. I did no1 recognize him. so I them both busy. Health Service officer. died of an aortic refused him entry:· Instead of a reprimand. aneurysm May 12 at a hospital in San Merriman received a letter of commenda DEATHS Diego. From 19-15 to 1954. he worked at tion from the dircc1or for performing his the ational Institute of Mental Health and duty ... John Stanford Nance. Jr., recently Dr. Hazel M. Aslakson. 79. a fom1cr offi at St. Elizabeths Hospital from 1960 to retired us NHLBI admi nistrative officer. a cial at IH who also had been an Am1y 1967 when he retired as superintendent. He post he has held for 16 years. He had nu rse and educator. died of cancer Apr. I at retired wi th the rank of assistant surgeon served al NHLB I since 1968 (when ii was her home in Fairfax. From 1968 to 1974 general. From 1967 10 1974. he was chief the Heart Insti tute) and at NIH since 1962. she had been project grants section chief in of drug dependency programs at the World when he join ed the Office of the Director as Nlffs nu rsing division. In 1992. she Hcu hh Organization in Geneva ... Dr. an administrati ve 1rainee. As a volunteer he returned 10 the Washington :irca after retir Theodore Cooper. 64, the board chaimtan has performed magic shows for children ut ing from East Carolina University where she and chief cxccu1i ve officer of 1hc Upjohn the Clinical Cen1er - a service he will con- was associate dean in 1hc nursing school and Co .. died Apr. 22 at 1he University of 1inuc to do. He performed a li11lc magic wo rked on 1he surgical curriculu m al the Virginia Medical Cc111cr in Charlottesville, during hi s rarewell when he wore a 1-shin uni vers i1 y·s medical school ... Anne Marie where he was being treated for bone mar with the slogan "I'm Retired. Having a Good Bahre, 58. an official of horse groups in row cancer. He had first come to NIH in Time Is My Job" ... Carl E. "Mickey" Montgomery and Frederick counties. died 1956 as a staff fell ow wi th the National Newmun, an x-rny 1echni cian at the Clinical May 22 as a result of injuries sulTcrcd thlll Heart lns1i1111e·s Clinic or Surgery. ln 1960. Center, has rc1ircd after a 35-year federa l day when she was thrown from a horse he joined the surgical faculty of St. Loui s career. Aflcr a s1in1 in 1he Army he came drnwn carriage. A member of1he NI H Golf Uni versity School of Medicine where he out 10N I1-1 in December 1963 10 begin work League and past member of 1hc NII-I Sailing rose through the ranks 10 professor. After in 1h1.: diagnostic radi ology dcpar1me111. He Association. she was known at NII-I for 1961. he served as director of that universi evcn1uall y moved 10 NHLBl's cardiac helping her husband Jim Buhre establish the ty's Center of Cardiovascular Research. In ca thetcrizat ion labora1ory where he worked Technical Sales Associution·s tent shows 1966. the Universi ty of cw Mexico on corom1ry dilatation procedures. research during the week or Re carch Festival :11 Medical School recruited him to be profes that led 10 a direct impact on the communi NIH ... Or. James H. Baxter. Jr., 79. a sor and chaim1an. depanment of phannacol ty. Newman has had a lifelong interest in medical director in the U.S. Public Health ogy. and professor of surgery. I-le secured a music. especially jazz percussion. I-le plays Service who retired from IH as a research leave of absence 10 return 10 rH to become the drums and the marimba. and planl> to scientist. died of a heart ailment May 5 at Hi's associate director for Anificial Hean immerse himself in music ... Emma his home in Bethesda. He joined IH in Myocardial Infarction Program. In March Twyman, EEO officer for the Division of 1950 and specialized in kidney diseases and 1968. he was named the seventh director of Research Grants. retired after a career 1han related heart problem at the NHLBI. He t HI and the first under the redesignatcd spanned more than 30 years. She began retired in 1976 ... Barbara Ellen llelmonl, name I-ILi. On Apr. 19. 197-1. he moved work ing for NIH in 1963. in 1hc Clinical an NIH employee for more than 26 years. downtown us HEW deputy assistum secre Center nutrition department. In 1970. she died on May 8 from chronic pulmonary dis t:lry for health. and on July I. 1975 was 1ook a posi 1i o11 al DRG as a clerk typist. and ease. Much of her NIH career centered sworn in as HEW assistant secreta ry for later became the library techn ician and EEO around children. From 1976 until her death health (sec photo). Hi s government service (Co111i1111ed 011 11ex1 pa111') 27 N I H A A UPDATE ended on Jan. 20. 1977. and shortly there testS ... Blanche E. Fors, a retired adminis assistant chief of the planning and control nfter he was appointed dean and provost of trative a5si~t.in1 in 1he digestive di!>t:il!>C section uf the Plant Engineering Branch ... 1he Cornell University School of Medicine branch of NIH. died of heart ailment~ Feb. 4 Lester Goodman, 65. a former chief of the until joining the Upjohn Co. in 1980. He at her home in Bethesda. She began work Biomedical Engineering and became executive vice president and was ing at NlH in 1961 and retired in 1976 ... Instrumentation Branch at NIH . died Apr. n:uncd board vice chltinnan in I 984 and Dr. Karl Fra nk, 76. who retired in 1979 12 al the Crystal Ci1y Nursing Center in chief executive officer in 1987. A devoted after 27 years as a neurophysiologisl at Arlington. He had a degenerative brain dis and pa.~sionatc NIH supporter, Cooper NlH, died of Parkinson ·s disease Feb. 25 at ease. He joined NIH in L965. Ln 1975. he responded unfailingly to every request for the Meridian nursing home in Silver Spring. moved to Minneapolis where he worked advice and council on IH programs. poli He lived at the Aspcnwood Retirement with a company specializing in cardiac cies and personnel. The NIHAA is espe Center. He was chief of tJ1e Laboratory of pacemakers. In 1989. he became a consul- cially in his debt for spearheading tJ1e cam Neural Control in the National lnstitule of 1ant to Case Wes1em Reserve u111il he paign 1ha1 raised 1he funds 1hat have sup Neurological and Communicative became ill and returned to 1he Washington ported the last 1wo years of publication of Disorders. conducting research in the area in 1983 ... Annie S. Gulik, I 00. a 1his newsletter ... Frances Irene CrJan, 67. development or devices 10 aid the neurolog retired purchasing agent with the General a secreiary at NIH from I 962 to 1975. died ically disabled ... Or. Walter R enrJ Services Administra1ion and a volun1eer a1 or emphysema Apr. 12 at her home in F r e~·gang, J r., a rel ired neurologist at lH. died of heart ailments Apr. I I at Villa Annapolis. She was secretary to the direc IMH. where he did basic research in nerve Rosa ursing Home in Mitchellville. Mel .... tors of the National Eye lnstitule and the and muscle physiology, died of cancer July Or. Alonzo R. Hayden, 68. a research Na1ional lns1i1u1e of Child Heahh and 20 at his home in Washington. He wenl to chemis1 at NIH. died of colon cancer Mar. Human Developmcnl and 10 1he executive work al NIMH in 1952 where he served as 2 1 at hi s home in Yonkers. N.Y. In 1952. he officer of the Naii onal Jns1i1ute of Neuro chief of 1he secti on of membrane physiolo joined lhc staff at NIH and specialized in logical Diseases trnd Stroke ... Or. E ldon gy and later as a senior researcher and med immunological identification of species in Eagles. 82. a physician who re1ired in 1979 ical director. He retired in I 972. For one meat. He left NIH in 1958 to work al as long1ime deputy director of the lns1itute of year he was a clinical professor of neurolo Walter Reed Army Medical Center and then eurological and Communicative Diseases gy at Georgetown University medical for tlle Department of Agriculture. He and S1roke, rlir,d nf congc~tive heart failure school. He also w:is a visiting scientist :11 moved to Yonkers in 1983 ... Dr. Mar. 14 at Montgomery General Hospital Cambridge University in England and a vis W illiam ina Armstrong Himwich, 8 I. a During his 15 years wi1h N INCDS. he was i1ing professor at the University of retired medical researcher who specialized clcpu1y to three instilutc directors. An experl Heidelberg in Germany ... Norman .). in various aspec1s of the brain and drngs in communicative disorders. wi1h an exten Gettings. who worked ai N"l H from I 949 that affec1 the nervous system. died of a sive background in public health. he was until he rc1irccl in I 978. d ied Mar. I I al stroke May I 1 at Howard County General known for his contribution to the study of Suburban Hospital in Bethesda. He held lhe Hospi1al in Columbia. She moved to 1hc hearing loss in school children in PittSburgh. position of acting maintenance superinten Washing1on area afler she retired in 1977 which set national standards for hearing dent when the Clinical Center first was from Galesburg State Research Ho pital in sensitivity and resuhcd in improved hearing completed and occupied. and retired as Ga.Jesburg, Ill. From 1979 to 1981 she was an indexer al 1hc National Library of Medicine ... Edith A. J ones, 73. a die1itian and nu1ritionis1 who was a retired NIH offi cial, died June 24 at Washington Adventis1 Hospital after surgery for a heart ailment. She joined the Public Health Service in the early I 950"s. In 1953. she became nu1rition department chief of NIH "s Clinical Center and remained 1herc as the chief dietitian officer before retiring in I 983 ... Dr. J .B. Horner Kuper, 83. a physicist and fonner department chainnan of Brookhaven National Laboratory on Long Island. died June 8 at the Glacier Hill Retiremenl Residence in Ann Arbor. Mich. of compli cations from a fall. Before Wnrlcl W:1r n he worked al NIH as a physicist ... Stephanie Lanterma n, 38, an employee of the Foundation for Advanced Education in the Sciences Inc .. died Mar. 10 at her home in J- Bethesda after a hean auack. She worked for the foundation since 1972 handling 1he Dr. Theodore Co oper is being sworn in as HEW assistant secretary for health by then HEW details and opera1ion of running the gradu secretary Caspar Weinberger. Cooper's wife " Patsy" is in the center and President Gerald ate school at I H as the a.-;sis1ant regis1rar Ford is on Cooper's right. (Photo courtesy of Mary Calley Hartman.) 28 SUMMER 1 9 9 3 ... Rose Ann LaRuc. 79. a fom1er adminis named for Hudson who was chief of the affairs where he coordinated cancer trative assistant at N IH. died of cancer July NIH Laboratory of ChemiSLI)' from 1929 10 research with 01J1er nations ... Waller I at her home in Treasure Island. Fla. She 1951. Richtmycr worked closely with Raymond Sceery. 73. a lawyer and psychi worked at NIH in the 1970's ... Dr. J a mes Hudson when he was in the laboratory. He atric social worker with the U.S. Public r. Lore, 70. a retired psychologist. speech also coedited the two-volume editi on of Health Service who retired as a captain in pathologist and audiologist. died of a heart ..The Collected Papers ofC.S. Hudson ..... 1987. died of cancer Mar. 17 at Bethesda ailment at his home in Arlington. His body Dr. William L. Roberson, 72. a retired Nav:1I Hospital. He joined the staff of NLH was found Feb. 24. He was a grants associ physician with the U.S. Public Health in 1956 and worked on a range of projects ate at NIH ... Patricia Stanton McLean, Service who worked at the National Cancer involving 2.500 newlywed couples. manic 77. a retired educator and leader in the den lnstirme. died on Mar. 10 al his home in depressivc patients. children with h)'Perac- tal hygienist profess ion. died of heart dis Mc Lean, Va. He was commissioned in the 1ivity. people with anorexia nervosa and ease on June 8 at the Westchester County U.S. Public Health Service in 1948 and in obsessive compulsive disorder. With all 1he Medical Center. She retired in 1977 as the 1962 was assigned to NCI. At the rime of projec ts he provided psychotherapy for director of Colu mbia University's Division his retirement in 1984 he was program individuals and families. He also coumeled of Dental Hygiene and was an assistant director of the Cancer Ce111ers Branch ... NIH employees with alcohol. drug. mental dean at Columbia's School of Demal ;met Roger L. Robertson, 73. a program analyst health and legal problems. He contributed Oral Surgery. She was a consultant 10 NIH with the Nati onal Institute of Mental Health extensively to the professional literature . ... Mary Bertha Medley, 80. the human for 2 1 years before retiring in 1979. died of After his official retiremelll he continued resources manager o r the Cystic Fibrosis cancer May 7 al his home in Kensington ... collaborating on several research projects ... Foundation and a former personnel official George R. Rogers, 64. an independent con Sally J . Stanley. 55. a member of the at NlH. died of a heart a11ack June 26 at her tractor affiliated with Blind Industries. Inc .. NHLBI intramural program for 33 years. home in Rockville. She began working for for more than 42 years and manager of died on Feb. 11 after a brief illness. She NIH in 1947 and retired as labor relations Bldg. 3 1's concession stand. died July I. started working at 1 rH in 1960 and joined chief in 1977. She worked for the Cystic He and his wife Margaret handled the brisk what is now the Laboratory of Cellular Fibrosis Foundation from 1980 until her snack business in Bldg. 31 for approximate Metabolism ... Dr. Michael Edward death ... .Julian M. Morris, 51. an employ ly 10 years ... Dr. Albert Sabin. 86. who Stanley, -l9. a Columbia University neuro ee :it N lH for :ilmost 30 years. died Apr. 18 developed the oml vaccine for poliomyc lit i ~ . scientist known nationally for research on at hi s home in Washington. D.C.. from died of congestive bean failure. Mar. 3 at the biochemistry of suicide. died at his complications related 10 AIDS. In 1963. he Georgetown University Medical Center. It home in Short Hills. N.J. of a hean a11ack. joined the NIH lnfonnati on Office as an has been estimated that by the time of his He was a consuhant for the National intern and in 1970 was named infonnation death about 5 million cases of polio and Ins1i1u1c of Mental Health. which provided officer al 1he National Eye lns1i1u1e where 500.000 deaths had been prevented by his grams for much of his work ... Dorothy he served 29 N I H A A UPDATE Smadel. 56. chief of the Laboratory of the opening day of the IH Child NIH Retrospectives Virology and Rickcttsiology of the NIH Development Center-the nursery Division of Biologics Standards, world school for children of NIH employees renowned for his pioneering assaul1s on .. . Two eminent women scien 1is1s-Dr. infectious diseases including typhoid Margaret Mead. world-famed an1hro fever. scrub lyphus •ind Rocky Mountain pologist. and Dame Janet Yuughan. an sported fever. died July 21 at University outstanding British pathologist have Hospital. Ballimore. after a hon illness. been appointed Fogarty Scholar -in Residence. This is 1he lirs1 time women Summer 1953 have been invited to join the program. On July 2, 1he Clinical Center was dedicated by DHEW Secretary Oveta Culp Hobby. extending 1he clinical ...... aspecLS of NIH" s research programs ... - ·- The NIH Record On July 6. the first pa1ien1 was admitted Summer 1973 --::.:- - 10 1he Clinical Cen1er by Dr. Roy Hem . - (see photo below). On May 29. 1973. Dr. Rober! S. Summer 1983 Stone was sworn in as the tenth director of NTH. Stone had been vice president Dr. Wallace Prescott Rowe. chief of for health sciences and dean of 1he the Labora1ory of Viral Disease~. School of Medicine a1 the University of NlAID, a world-renowned virologis1 New Mexico, Albuquerque ... The Clini and a leader in rccombinanl DNA cal Center commemorated 1he 201h anni research. died of cancer. July 4. at versary of its opening wi1h a day-long Johns Hopkins Hospi1al. Baltimore. 1he scien1iftc seminar on the impac1 of basic city of his binh ... Dr. T. Franklin Summer l963 science on clinical research and med Williams was insialled a second direc ical practice ... June 18. 1973. marked tor of the ational ln, 1itute on Aging. The impac1 of clen1al research in 1he United Sta1es during 1he past J 5 years was surveyed by speakers in a scientific scm i nur held on June 14 in observance or 1hc fifteenth anniversary or the Nmional lns1i1u1c of Dental Research ... Charles Meredith, a 67-year-old The new 9-story. uir-condi1ionecl farm er, was the first patient Wes1wood Building, located at 5333 admitted to the Clinical Center Wes1bard Avenue. Beth esda, soon will under the care of Dr. Roy Hertz house 1he offices of nearly 1.000NI1-1 (rear), who treated him with hor employees. including 1he Division or mone therapy. "We had mar Research Grants. 1he Naiional fns1iwtc velous, wonderful nurses," Hertz of General Medical Sciences. and all said of the Clinical Center staff. Standing behind Meredith is ex1ramural programs excep1 those of Nadine Luxmore and holding the NIMH ... Dr. DeWi11 Sletten. Jr.. for chart on his side is Elizabeth mer clirec1or of in1ramural research, Walker. Na1 ional lnsti1u1 e of Ar1hri1is and Metnbolic Diseases. was honored with a farewell recept ion in Wilson Hall, Friday. May 24. He became dean of 1he new Ru1gers Universi 1y M edical School las1 November ... Dr. Joseph E. 30 SUMMER 1 9 9 3 Clinical Center's 40th Anniversary Highlighted by Alumni, Nobelists Dr. Julius Axelrod: " I think I came to NIH at the right lime. II was the right place for me. I think if I worked any place else I Dr. Christian B. Anfinsen: "I remember this place with tremendous affection and grateful never would have gotten as far as I have. " ness, because of the set up here. It was so ideal for producing scientific work. " Dr. Marshall W. Nirenberg: "I have to say that I'm proud to be part of an institution ... that's contributed so much to the advance ment of biomedical sciences. And I also Dr. D. Carlton Gajdusek: "I came here in 1958. I was told 'you can do anything you want.' sense the opportunities that lie just around II was right. It was a period of logarithmic expansion." the corner for the next new discoveries. " 31