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Meduni Wien Imagebroschuere
We shape the future Key numbers IN THE TOP 100 worldwide in the medicine category of leading university rankings 8,000 students outpatient treatments annually at Vienna General Hospital 5,750 employees operations annually, including 750 transplants Doing everything to support health Founded in 1365 as the medical faculty of the University of Vienna and made an independent university in 2004, today MedUni Vienna is among Europe’s most highly respected centres of medical training and research. 2 Focused programmes of study MedUni Vienna has an educational offering that ranges from undergraduate degrees to continuing education courses and PhD programmes. MEDICINE DEGREE DENTISTRY DEGREE PROGRAMME PROGRAMME MEDICAL INFORMATICS PHD PROGRAMMES MASTER’S PROGRAMME POSTGRADUATE APPLIED MEDICAL CONTINUING SCIENCE DOCTORAL EDUCATION COURSES PROGRAMME AND CERTIFICATE COURSES Measurable success Since its establishment as an independent university in 2004, research output has grown at MedUni Vienna. This can be seen in the university’s consistent upward progress in significant rankings including the US News Best Global Universities Rankings and the QS World University Rankings. 3 Gerard van Swieten Carl von Rokitansky Josef Skoda Ignaz Philipp Semmelweis Karl Landsteiner Róbert Bárány 4 City of Medicine Medical pioneers: the Vienna School of Medicine Modern medicine was born in the theories of Ignaz Philipp Jewish heritage or dissident Vienna. Gerard van Swieten, Semmelweis in clinical practice thinkers, and were murdered, personal physician to Empress for the first time anywhere in expelled or forced to flee by Maria Theresa, introduced bed- the world. In the 20th century, the National Socialist regime side teaching into medical edu- Karl Landsteiner and Róbert – among them Sigmund Freud, cation in the 18th century. -
August and Marie Krogh August and Marie Krogh
August and Marie Krogh August and Marie Krogh LIVES IN SCIENCE Bodil Schmidt-Nielsen, Dr. Odont, Dr. phil. Professor Emeritus and Aqjunct Professor, Department of Physiology, University of Florida SPRINGER NEW YORK 1995 Oxford University Press Oxford New York Toronto Delhi Bombay Calcutta Madras Karachi Kuala Lumpur Singapore Hong Kong Tokyo Nairobi Dar es Salaam Cape Town Melbourne Auckland Madrid and associated companies in Berlin lbadan Copyright © 1995 by the American Physiological Society Originally published by American Physiological Society in 1995 Softcover reprint of the hardcover 1st edition 1995 Oxford is a registered trademark of Oxford University Press AII rights reserved. No part of this publication may be reproduced, stored in a retrieval system, or transmitted, in any form or by any means, electronic, mechanical, photocopying, recording, or otherwise, without the prior permission of Oxford University Press. Library of Congress Cataloging-in-Publication Data Schmidt-Nielsen, Bodil. August and Marie Krogh : lives in science by Bodil Schmidt-Nielsen. p. cm. Includes index. ISBN 978-1-4614-7530-9 (eBook) DOI 10.1007/978-1-4614-7530-9 1. Krogh, August, 1874-1949. 2. Krogh, Marie, 1874-1943. 3. Physiologists-Denmark-Biography. I. Title. QP26.K76S35 1995 591.1'092-dc20 [B] 94-20655 9 8 7 6 5 4 3 2 1 Printed in the United States of America on acid-free paper Preface When my father August Krogh died in 1949, 1 was with him in Den mark. My stay in Denmark was prolonged for another two months due to a concussion 1 sustained in an automobile accident, which occurred shortly after his death. -
Medicine Merit Badge Requirements
Columbia-Montour Council MEDICINE NOTES FOR SCOUTS: LIMITED TO 20 SCOUTS 1. Scouts are required to obtain the Medicine merit badge book, study its contents and be prepared to discuss all requirements with the counselor. 2. All items listed in bold type are prerequisites that MUST be completed prior to the event and emailed to your counselor at least 2 weeks before MBC. 3. Scouts are required to download and use the Workbook, and have all requirements filled out before they arrive the day of the event, which may be downloaded at http://www.MeritBadge.org . 4. Counselor: Ralph Baker 570-271-1049, [email protected] Medicine merit badge requirements 1. Discuss with your counselor the influence that EIGHT of the following people or events had on the history of medicine: a. Hippocrates b. William Harvey c. Antoine van Leeuwenhoek d. Edward Jenner e. Florence Nightingale f. Louis Pasteur g. Gregor Mendel h. Joseph Lister i. Robert Koch j. Daniel Hale Williams k. Wilhelm Conrad Roentgen l. Marie and Pierre Curie m. Walter Reed n. Karl Landsteiner o. Alexander Fleming p. Charles Richard Drew q. Helen Taussig r. James Watson and Francis Crick s. Jonas Salk 2. Explain the Hippocratic Oath to your counselor, and compare to the original version to a more modern one. Discuss to whom those subscribing to the original version of the oath owe the greatest allegiance. 3. Discuss the health-care provider-patient relationship with your counselor, and the importance of such a relationship in the delivery of quality care to the patient. Describe the role of confidentiality in this relationship. -
Animal Models of Obesity and Diabetes Mellitus
UC Davis UC Davis Previously Published Works Title Animal models of obesity and diabetes mellitus. Permalink https://escholarship.org/uc/item/3z3879vp Journal Nature reviews. Endocrinology, 14(3) ISSN 1759-5029 Authors Kleinert, Maximilian Clemmensen, Christoffer Hofmann, Susanna M et al. Publication Date 2018-03-01 DOI 10.1038/nrendo.2017.161 Peer reviewed eScholarship.org Powered by the California Digital Library University of California REVIEWS Animal models of obesity and diabetes mellitus Maximilian Kleinert1–4, Christoffer Clemmensen1–3, Susanna M. Hofmann3,5,6, Mary C. Moore7, Simone Renner3,8, Stephen C. Woods9, Peter Huypens3,10, Johannes Beckers3,10,11, Martin Hrabe de Angelis3,10,11, Annette Schürmann3,12, Mostafa Bakhti3,5,13, Martin Klingenspor14,15,16, Mark Heiman17, Alan D. Cherrington7, Michael Ristow18, Heiko Lickert3,5,13, Eckhard Wolf3,8, Peter J. Havel19, Timo D. Müller1–3 and Matthias H. Tschöp1–3 Abstract | More than one-third of the worldwide population is overweight or obese and therefore at risk of developing type 2 diabetes mellitus. In order to mitigate this pandemic, safer and more potent therapeutics are urgently required. This necessitates the continued use of animal models to discover, validate and optimize novel therapeutics for their safe use in humans. In order to improve the transition from bench to bedside, researchers must not only carefully select the appropriate model but also draw the right conclusions. In this Review, we consolidate the key information on the currently available animal models of obesity and diabetes and highlight the advantages, limitations and important caveats of each of these models. On the current trajectory, over half of the adult pop- To tackle these objectives, researchers rely on diverse ani- ulation in the United States will be obese by 2030, and mal models that span multiple species and strategic scien- similar increments are likely to occur in other developed tific approaches. -
100858 AVANCES 26 5Indd
avances en Diabetología Av Diabetol. 2010;26:373-82 Historical perspective From pancreatic extracts to artificial pancreas: history, science and controversies about the discovery of the pancreatic antidiabetic hormone V: The controversy. Who discovered insulin? A. de Leiva-Pérez1, E. Brugués-Brugués1,2, A. de Leiva-Hidalgo1,2,3,4 1Fundación DIABEM. 2Servicio de Endocrinología y Nutrición e Instituto de Investigación. Hospital de la Santa Creu i Sant Pau. Barcelona. 3Centro de Historia de la Ciencia. Universitat Autònoma de Barcelona. 4CIBER-BBN-ISCIII The Nobel Prize controversy were provided by two members of the objection was to making an award on “he- The 1923 Nobel Award Nobel Committee: John Sjöqvist, Profes- resy evidence” from unknown persons or of Physiology or Medicine sor of Chemistry and Pharmacy, and Hans on statements in the two appraisals, like In April 1923, a total of 57 nominations Christian Jacobaeus, Professor of Internal “it is beyond doubt”, or comments as with merits were reviewed by the Nobel Medicine. Sjökvist arrived to the same ”things that are thought as very possible”; Committee. The examiners concluded conclusion as A. Krogh: the prize should the Assembly should take only verifi able that the discovery of insulin was of funda- be divided between Banting and Macleod. facts. The Committee reconsidered and mental importance. The archives of the Professor Göran Liljstrand was the Secre- reconfirmed its previous recommenda- Karolinska Institute depict that Macleod tary of the Nobel Committee from 1918 to tion. August Krogh was identifi ed as the and Banting were nominated for the fi rst 1960. He was a great friend of August source of the “heresy evidence”; he time in 1923: Banting by G.W. -
(Rh) Factor Studies, Dr. Bruce Chown, and the Faculty Of
THE BIRTH OF A MEDICAL RESEARCH PROGRAMME. THE RHESUS (RH) FACTOR STUDIES, DR. BRUCE CHOWN, AND THE FACULTY OF MEDICINE, UNIVERSITY OF MANITOBA, 1883-1946. By C. Peter W. Warren A Thesis submitted to the Faculty of Graduate Studies of the University of Manitoba in partial fulfilment of the requirements of the degree of MASTER OF ARTS Joint Master‟s Program Departments of History University of Manitoba / University of Winnipeg Winnipeg Copyright © 2011 by C. Peter W. Warren i NOTE TO READERS Dr. C. Peter Warren passed away suddenly on 3 May 2011. He had finished this thesis, and we were in the process of scheduling his defence. Dr. Warren did not defend the thesis, but Dr. Greg Smith, Chair of the Joint Master‟s Program, and Dr. J Doering, Dean of the Faculty of Graduate Studies, agreed with Dr. Warren‟s family that the thesis should be made available for future scholars. Dr. Warren‟s thesis examining committee (Drs. Esyllt Jones, Emőke J. E. Szathmáry and Gerald Friesen) read the thesis and suggested a small number of typographical and editorial changes, and I am very grateful to them for their commitment to finishing this project. In two cases, I have inserted comments [ed.:] in order to clarify particular points. Apart from a small number of obvious omissions and errors which I have silently corrected, the work and words are as Dr. Warren wrote them. James Hanley Associate Professor of History University of Winnipeg 15 August 2011 ii Abstract The thesis is an analysis of the birth of the Rhesus (Rh) Factor Research Programme in the Faculty of Medicine, University of Manitoba. -
Balcomk41251.Pdf (558.9Kb)
Copyright by Karen Suzanne Balcom 2005 The Dissertation Committee for Karen Suzanne Balcom Certifies that this is the approved version of the following dissertation: Discovery and Information Use Patterns of Nobel Laureates in Physiology or Medicine Committee: E. Glynn Harmon, Supervisor Julie Hallmark Billie Grace Herring James D. Legler Brooke E. Sheldon Discovery and Information Use Patterns of Nobel Laureates in Physiology or Medicine by Karen Suzanne Balcom, B.A., M.L.S. Dissertation Presented to the Faculty of the Graduate School of The University of Texas at Austin in Partial Fulfillment of the Requirements for the Degree of Doctor of Philosophy The University of Texas at Austin August, 2005 Dedication I dedicate this dissertation to my first teachers: my father, George Sheldon Balcom, who passed away before this task was begun, and to my mother, Marian Dyer Balcom, who passed away before it was completed. I also dedicate it to my dissertation committee members: Drs. Billie Grace Herring, Brooke Sheldon, Julie Hallmark and to my supervisor, Dr. Glynn Harmon. They were all teachers, mentors, and friends who lifted me up when I was down. Acknowledgements I would first like to thank my committee: Julie Hallmark, Billie Grace Herring, Jim Legler, M.D., Brooke E. Sheldon, and Glynn Harmon for their encouragement, patience and support during the nine years that this investigation was a work in progress. I could not have had a better committee. They are my enduring friends and I hope I prove worthy of the faith they have always showed in me. I am grateful to Dr. -
Health and the People Part Four: Modern Medicine
TURTON SCHOOL HISTORY DEPARTMENT – KNOWLEDGE ORGANISER – GCSE Modern treatment of disease The impact of war and technology on surgery Modern public health Modern treatment of disease: the development of The impact of war and technology on surgery: plastic surgery; blood transfusions; X‐rays; transplant surgery; modern surgical methods, including lasers, radiation therapy During the Boer War of 1899 to 1902, the government discovered that half the pharmaceutical industry; penicillin, its discovery and keyhole surgery. the volunteers for the army were unfit for service. In the 1900s, therefore, by Fleming, its development; new diseases and the Liberal government passed a string of welfare reforms based on 'the treatments, antibiotic resistance; alternative Surgeons in WW1 had the opportunity to experiment with new techniques. Surgeons developed techniques to repair broken bones, and perform skin grafts – plastic personal principle' – the belief that the government had a responsibility to treatments. surgery. Surgery of the eye, ear, nose and throat all improved rapidly. care for the individual citizen: X‐rays were first discovered 20 years before the war. Hospitals installed X‐ray machines, but it was the First World War which confirmed their importance. X‐rays 1906, local authorities were given the right to provide free school The key discovery in the twentieth century was the immediately improved the success rate of surgeons in removing deeply lodged bullets and shrapnel which would otherwise have caused fatal infections. During WW1 the meals for poor children development of Penicillin; following advances occurred: 1907, the School Medical Service gave free health checks Alexander Fleming 1908, the government introduced pensions for old people Penicillin was discovered by Alexander Fleming when Scientists didn’t know about different blood groups. -
Krogh's Principle for Musculoskeletal Physiology and Pathology
Journal of Musculoskeletal J Musculoskelet Neuronal Interact 2018; 18(3):284-291 and Neuronal Interactions Perspective Article Krogh’s principle for musculoskeletal physiology and pathology Seth W. Donahue Department of Biomedical Engineering, University of Massachusetts, USA Abstract August Krogh was a comparative physiologist who used frogs, guinea pigs, cats, dogs, and horses in his research that led to his Nobel Prize on muscle physiology. His idea to choose the most relevant organism to study problems in physiology has become known as Krogh’s principle. Indeed, many important discoveries in physiology have been made using naturally occurring animal models. However, the majority of research today utilizes laboratory mouse and rat models to study problems in physiology. This paper discusses how Krogh’s principle can be invoked in musculoskeletal research as a complementary approach to using standard laboratory rodent models for solving problems in musculoskeletal physiology. This approach may increase our ability to treat musculoskeletal diseases clinically. For example, it has been noted that progress in osteogenesis imperfecta research has been limited by the absence of a naturally occurring animal model. Several examples of naturally occurring animal models are discussed including osteoarthritis and osteosarcoma in dogs, resistance to disuse induced bone and skeletal muscle loss in mammalian hibernators, and bone phenotypic plasticity in fish lacking osteocytes. Many musculoskeletal diseases (e.g., osteoarthritis) occur naturally in companion animals, which may provide clues on etiology and progression of musculoskeletal diseases and accelerate the development of pharmaceutical therapies for humans. Keywords: Animal Models, Comparative Physiology, Companion Animals, Evolutionary Physiology, Musculoskeletal August Krogh: his research and his principle plant, insect, amphibian, bird, mammal) to study problems in physiology. -
Timeline of Immunology
TIMELINE OF IMMUNOLOGY 1549 – The earliest account of inoculation of smallpox (variolation) occurs in Wan Quan's (1499–1582) 1718 – Smallpox inoculation in Ottoman Empire realized by West. Lady Mary Wortley Montagu, the wife of the British ambassador to Constantinople, observed the positive effects of variolation on the native population and had the technique performed on her own children. 1796 – First demonstration of smallpox vaccination (Edward Jenner) 1837 – Description of the role of microbes in putrefaction and fermentation (Theodore Schwann) 1838 – Confirmation of the role of yeast in fermentation of sugar to alcohol (Charles Cagniard-Latour) 1840 – Proposal of the germ theory of disease (Jakob Henle) 1850 – Demonstration of the contagious nature of puerperal fever (childbed fever) (Ignaz Semmelweis) 1857–1870 – Confirmation of the role of microbes in fermentation (Louis Pasteur) 1862 – Phagocytosis (Ernst Haeckel) 1867 – Aseptic practice in surgery using carbolic acid (Joseph Lister) 1876 – Demonstration that microbes can cause disease-anthrax (Robert Koch) 1877 – Mast cells (Paul Ehrlich) 1878 – Confirmation and popularization of the germ theory of disease (Louis Pasteur) 1880 – 1881 -Theory that bacterial virulence could be attenuated by culture in vitro and used as vaccines. Proposed that live attenuated microbes produced immunity by depleting host of vital trace nutrients. Used to make chicken cholera and anthrax "vaccines" (Louis Pasteur) 1883 – 1905 – Cellular theory of immunity via phagocytosis by macrophages and microphages (polymorhonuclear leukocytes) (Elie Metchnikoff) 1885 – Introduction of concept of a "therapeutic vaccination". Report of a live "attenuated" vaccine for rabies (Louis Pasteur and Pierre Paul Émile Roux). 1888 – Identification of bacterial toxins (diphtheria bacillus) (Pierre Roux and Alexandre Yersin) 1888 – Bactericidal action of blood (George Nuttall) 1890 – Demonstration of antibody activity against diphtheria and tetanus toxins. -
Polyuria) Mellitus – Sweet
Hormones: the birth of a concept and how it gained recognition U3A Course, Spring Series 2017 Gil Barbezat What I plan to talk about: • First Session: History of hormones; concepts to chemicals Stories behind some key discovery milestones Technological help in advances • Second Session: How hormones work Hormones’ role in digestion Gut hormones in excess (tumours) What do you associate with the word ‘Hormone’ • Sex, Puberty, Menopause? • Body building, Athletes? • Maybe? Digestion Urine production Blood production and BP Brain function • Regulates our entire metabolism Early ‘application’ - Eunuchs • Intentional castration • Summerian city of Lagash in 21st C BCE Southern Mesopotamia (Iraq) • Applications: Guardians of rulers or women Singers Courtiers and domestics Why did this happen? Albrecht von Haller (1708 – 77) • Swiss poet, naturalist, theologian, anatomist, physiologist • “Father of experimental physiology” • Body ‘emanations’: Bile digests fat Body a reactive organism Salivary gland duct a blood vessel (MD) Theophile de Bordeu (1722 – 76) • French poet, philosopher, physician • Organs specific sensibilities • Each organ of the body produced a specific ‘emanation’ (humour) which it secreted into the bloodstream Claude Bernard (1813 – 78) Claude Bernard • Vaudeville comedy to medicine Med School in Paris 1834; physiology • Father of “Experimental medicine” Vivisection • ‘Milieu interieur’ Walter Bradford Cannon (1871 – 1945) • American physiologist at Harvard • Worked in lab of Henry Bowditch, a pupil of Bernard • Enlarged Bernard’s -
Banting and Best: the Extraordinary Discovery of Insulin
106 Rev Port Endocrinol Diabetes Metab. 2017;12(1):106-115 Revista Portuguesa de Endocrinologia, Diabetes e Metabolismo www.spedmjournal.com Artigo de Revisão Banting and Best: The Extraordinary Discovery of Insulin Luís Cardosoa,b, Dírcea Rodriguesa,b, Leonor Gomesa,b, Francisco Carrilhoa a Department of Endocrinology, Diabetes, and Metabolism, Centro Hospitalar e Universitário de Coimbra, Coimbra, Portugal b Faculty of Medicine of the University of Coimbra, Coimbra, Portugal INFORMAÇÃO SOBRE O ARTIGO ABSTRACT Historial do artigo: Diabetes was a feared disease that most certainly led to death before insulin discovery. During the first Recebido a XX de XXXX de 201X two decades of the 20th century, several researchers tested pancreatic extracts, but most of them caused Aceite a XX de XXXX de 201X Online a 30 de junho de 2017 toxic reactions impeding human use. On May 1921, Banting, a young surgeon, and Best, a master’s student, started testing the hypothesis that, by ligating the pancreatic ducts to induce atrophy of the exocrine pancreas and minimizing the effect of digestive enzymes, it would be possible to isolate the Keywords: internal secretion of the pancreas. The research took place at the Department of Physiology of the Diabetes Mellitus University of Toronto under supervision of the notorious physiologist John MacLeod. Banting and Insulin/history Best felt several difficulties depancreatising dogs and a couple of weeks after the experiments had Pancreatic Extracts/history begun most of the dogs initially allocated to the project had succumbed to perioperative complications. When they had depancreatised dogs available, they moved to the next phase of the project and prepared pancreatic extracts from ligated atrophied pancreas.