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Anne McLaren Edith Saunders Francis Crick 1927-2007 1865-1945 1916-2004 Known for mouse genetics Known for plant genetics Known for the double helix Fame 62 Fame 41 Fame 99 Impact 77 Impact 28 Impact 93 Nobel Prizes 0 Nobel Prizes 0 Nobel Prizes 1 Number of Children 3 Number of Children 0 Number of Children 3 Special Power (ethics) 18 Special Power (vigour) 30 Special Power (communication) 3 McLaren’s studies of mice and other mammals With William Bateson and Reginald Punnett, Working with James Watson and inspired by revealed that the external environment Saunders confirmed Mendel’s results but also Rosalind Franklin’s X-ray images, Crick built influences an embryo’s gene expression during showed that inheritance of combinations like the double-helix structure of DNA. He also development, which paved the way for in vitro flower colour and pollen shape would break proposed the central dogma of molecular fertilisation and fertility treatment in humans. Mendel’s laws, now known to be due to biology: information cannot flow from genetic linkage. proteins to genes. Frederick Sanger Mary Lyon Paul Nurse 1918-2013 1925-2014 1949- Known for DNA sequencing Known for X-chromosome inactivation Known for the cell cycle Fame 82 Fame 63 Fame 74 Impact 92 Impact 81 Impact 92 Nobel Prizes 2 Nobel Prizes 0 Nobel Prizes 1 Number of Children 3 Number of Children 0 Number of Children 2 Special Power (boating) 1 Special Power (rigour) 22 Special Power (astronomy) 7 One of only four scientists with two Nobels, Lyon helped explain why women who After Leland Hartwell identified the gene that Sanger won his first for methods that identify only ‘carry’ a genetic disorder can exhibit controls when yeast cells can enter a growth amino acids in proteins and shared his second symptoms. She proposed that in female phase during the cell-division cycle, Nurse with Walter Gilbert for reading the sequence of mammals, one of the two X chromosomes is discovered the gene controlling whether cells nucleotide letters in DNA. randomly silenced during early development, a can pass a checkpoint before they divide in two. process dubbed ‘Lyonisation’. Ronald Fisher William Bateson William Hamilton 1890-1962 1861-1926 1936-2000 Known for population genetics Known for Mendelian genetics Known for kin selection Fame 87 Fame 70 Fame 74 Impact 94 Impact 50 Impact 98 Nobel Prizes 0 Nobel Prizes 0 Nobel Prizes 0 Number of Children 8 Number of Children 3 Number of Children 3 Special Power (eccentricity) 2 Special Power (feminism) 20 Special Power (curiosity) 11 A genius in statistics, Fisher incorporated Bateson was an early champion of Mendelian Hamilton showed that natural selection Mendel’s concept of heredity into Charles principles. After Mendel’s research from 1865 can still favour costly social behaviours like Darwin’s theory of natural selection. With was rediscovered in 1900, he coined the term altruism if it helps relatives (kin) as they share fellow population geneticists JBS Haldane ‘genetics’ for the study of heredity and, with the same genes, a theory of evolutionary and Sewall Wright, he developed the Edith Saunders, founded the Genetics Society. fitness made famous by Richard Dawkins’ book modern evolutionary synthesis. The Selfish Gene. Charlotte Auerbach Christiane Nüsslein-Volhard Elizabeth Blackburn 1899-1994 1942- 1948- Known for chemical mutagenesis Known for embryonic development Known for telomeres Fame 68 Fame 69 Fame 82 Impact 50 Impact 88 Impact 96 Nobel Prizes 0 Nobel Prizes 1 Nobel Prizes 1 Number of Children 0 Number of Children 0 Number of Children 1 Special Power (teaching) 28 Special Power (philanthropy) 12 Special Power (mentoring) 8 After Hermann Muller had shown that radiation By creating mutant insects and comparing Blackburn and Jack Szostak discovered DNA can generate mutations in fruit flies, Auerbach their abnormal features, Nüsslein-Volhard sequences called telomeres that cap the and JM Robson showed that mustard gas and Eric Wieschaus identified key genes ends of chromosomes to protect the genetic could also alter genes, revealing that chemical that control the number and orientation of material. With Carol Greider, she then identified mutagens can affect genes too. segments in the body of a fruit-fly embryo. the enzyme that builds those telomeres. François Jacob Gregor Mendel Oswald Avery 1920-2013 1822-1884 1877-1955 Known for gene regulation Known for the laws of inheritance Known for the genetic material Fame 68 Fame 100 Fame 80 Impact 79 Impact 32 Impact 56 Nobel Prizes 1 Nobel Prizes 0 Nobel Prizes 0 Number of Children 4 Number of Children 0 Number of Children 0 Special Power (philosophy) 6 Special Power (perseverance) 25 Special Power (eloquence) 23 Jacob and Jacques Monod’s work on E. coli Mendel’s breeding experiments with pea plants Together with Colin MacLeod and Maclyn showed that genetic switches control the showed that characteristics such as flower McCarty, Avery’s experiments isolated the production of proteins using instructions from colour and seed shape are inherited according material that enabled Pneumococcus bacteria DNA, which involved copying that information as to specific laws and determined by unseen to inherit virulent features, which suggested an intermediate now known as ‘messenger RNA’. factors, units of heredity now called ‘genes’. that genes are made of that material, the molecule DNA. Sydney Brenner Tomoko Ohta Tsuneko Okazaki 1927-2019 1933- 1933- Known for organ development Known for nearly-neutral evolution Known for DNA replication Fame 77 Fame 57 Fame 52 Impact 89 Impact 80 Impact 59 Nobel Prizes 1 Nobel Prizes 0 Nobel Prizes 0 Number of Children 3 Number of Children 1 Number of Children 2 Special Power (mischief) 4 Special Power (persuasiveness) 21 Special Power (resilience) 24 Brenner followed the effects of mutations on After Motoo Kimura had suggested that One strand in the double helix cannot be the development of nematode worms to reveal mutations which are neither good nor bad will copied continuously during replication so how cells divide and differentiate to form spread by chance, Ohta’s theory of molecular cells will combine pieces of DNA, short various organs, which John Sulston and Robert evolution revealed how mildly harmful ‘nearly sequences of nucleotides discovered by Horvitz later showed requires programmed neutral’ mutations can persist in a population’s Tsuneko and her husband Reiji that are cell death. gene pool. now called ‘Okazaki fragments’. Barbara McClintock Esther Lederberg George Beadle 1902-1992 1922-2006 1903-1989 Known for mobile genetic elements Known for bacterial genetics Known for one gene - one enzyme Fame 91 Fame 71 Fame 69 Impact 78 Impact 52 Impact 60 Nobel Prizes 1 Nobel Prizes 0 Nobel Prizes 1 Number of Children 0 Number of Children 0 Number of Children 1 Special Power (independence) 10 Special Power (music) 27 Special Power (climbing) 15 McClintock discovered transposable elements Lederberg discovered lambda phage, a virus Beadle and Edward Tatum exposed bread or ‘jumping genes’ in maize (corn) that can that infects E. coli, and the ‘Fertility factor’ that mould to X-rays and found that genetic move around chromosomes. With Harriet many bacteria need for sexual reproduction. mutations alter the enzyme that catalyses Creighton, she also observed that genes are She also invented techniques that helped her a particular biochemical reaction, which exchanged by chromosomal crossover during first husband Joshua win a Nobel prize. suggested that each gene encodes the the process of meiosis. instructions for making one enzyme. Janet Rowley Jennifer Doudna Marshall Nirenberg 1925-2013 1964- 1927-2010 Known for cancer genetics Known for CRISPR gene editing Known for the genetic code Fame 61 Fame 71 Fame 69 Impact 86 Impact 98 Impact 72 Nobel Prizes 0 Nobel Prizes 0 Nobel Prizes 1 Number of Children 4 Number of Children 1 Number of Children 0 Special Power (cycling) 13 Special Power (gardening) 17 Special Power (precision) 14 Rowley showed that cancer is a genetic Doudna and Emmanuelle Charpentier modified Nirenberg helped crack the genetic code that disease by observing the movement a bacterial defence system that uses a genetic translates instructions encoded in DNA to the or ‘translocation’ of DNA between two sequence called ‘CRISPR’ to guide the enzyme language of proteins. With Heinrich Matthaei, he chromosomes in patients with leukaemia, a Cas9 to cut viral DNA, creating a gene-editing deciphered the first ‘codon’ to demonstrate that discovery that enabled the development of tool that can target specific DNA sequences. each of DNA’s code words is three letters long. chemotherapy drugs. Mary-Claire King Nettie Stevens Phillip Sharp 1946- 1861-1912 1944- Known for human genetics Known for sex determination Known for split genes Fame 74 Fame 74 Fame 64 Impact 86 Impact 32 Impact 100 Nobel Prizes 0 Nobel Prizes 0 Nobel Prizes 1 Number of Children 1 Number of Children 0 Number of Children 3 Special Power (activism) 19 Special Power (creativity) 29 Special Power (farming) 5 King isolated BRCA1 and BRCA2, genes that Stevens discovered that sex is determined by Sharp and Richard Roberts revealed that genes normally suppress tumours but can cause chromosomes after observing that mealworm are not always a continuous DNA sequence breast cancer when mutated. With Allan Wilson, eggs fertilised by sperm carrying a large but are split into segments that can be spliced she also showed that amino acid sequences in X chromosome produced female beetles, together in alternative
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    111 let Nobelových cen MENDEL FORUM 2011 Projekt „Od fyziologie k medicíně“ CZ.1.07/2.3.00/09.0219, který je prezentován v rámci konference Mendel Forum 2011, je spolufinancován Evropským sociálním fondem a státním rozpočtem České republiky. Mendelianum MZM, Brno Ústav fyziologie FVL VFU Brno ÚŽFG AV ČR, v.v.i., Brno ISBN 978-80-7305-132-7 MENDEL FORUM 2011 25. - 26. října 2011 Dietrichsteinský palác Zelný trh, Brno PROGRAM úterý 25. října 2011 8:30 – 9:00 registrace, zahájení Sekce: OD FYZIOLOGIE K MEDICÍNĚ 9:00 – 9:30 Od fyziologie k medicíně: vzdělávací projekty (I. Fellnerová) 9:30 – 10:00 Fyziologie/medicína v Nobelových cenách (J. Doubek) Sekce: GENETIKA-MENDEL 9:30 – 10:00 Mendel Memorial Medal Mendel Lecture (S. Zadražil) 10:30 – 11:00 diskuse, přestávka s občerstvením 2 11:00 - 11:30 Mendel – neustálá výzva (J. Sekerák) 11:30 – 12:00 Mendel, Biskupský dvůr a počátky vědy na Moravě (J. Mitáček) s navazující odpolední prohlídkou Biskupského dvora středa 26. října 2011 Sekce: NOBELOVY CENY 21. STOLETÍ 9:00 – 9:30 Nobelovy ceny v novém tisícíletí (E. Matalová) 9:30 – 10:00 Helicobacter pylori (M. Heroldová) 10:00 – 10:30 Umlčování genů (M. Buchtová) 10:30 – 11:00 přestávka 3 11:00 – 11:30 Telomery a nesmrtelnost (L. Dubská) 11:30 – 12:00 In vitro fertilizace (B. Kuřecová) s navazující diskusí a občerstvením ************************************** 111 let Nobelových cen http://nobelprize.org/nobel_prizes/about/ 4 Seznam přednášejících, kontakty doc. RNDr. Marcela Buchtová, Ph.D Ústav živočišné fyziologie a genetiky AV ČR, v.v.i., Brno, Fakulta veterinárního lékařství, VFU Brno [email protected], www.iapg.cas.cz prof.