SIR PAUL NURSE President, Royal Society of London; Director, UK Centre for Medical Research and Innovation; Nobel Laureate

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SIR PAUL NURSE President, Royal Society of London; Director, UK Centre for Medical Research and Innovation; Nobel Laureate

Program on SCIENCE & DEMOCRACY Science, Technology & Society LECTURE SERIES 2013 HARVARD KENNEDY SCHOOL HARVARD UNIVERSITY SIR PAUL NURSE President, Royal Society of London; Director, UK Centre for Medical Research and Innovation; Nobel Laureate MAKING SCIENCE WORK WITH PANELISTS WEDNESDAY Eric Lander Broad Institute and Biology, MIT February 6, 2013 Lisa Randall 5:00-7:00pm Physics, Harvard University Pfizer Lecture Hall Charles Rosenberg Mallinckrodt Chemistry Lab B23 History of Science, Harvard University 12 Oxford Street MODERATED BY Sheila Jasanoff Harvard University Harvard Kennedy School CO-SPONSORED BY Program on Harvard University Harvard School of Harvard University Center for the Engineering and Graduate School Science, Technology & Society Environment Applied Sciences of Design HARVARD KENNEDY SCHOOL HARVARD UNIVERSITY http://sts.hks.harvard.edu/ Program on SCIENCE & DEMOCRACY Science, Technology & Society LECTURE SERIES 2013 HARVARD KENNEDY SCHOOL HARVARD UNIVERSITY Sir Paul Nurse is a British geneticist and cell biologist. He became the 60th President of The Royal Society in December 2010. As a geneticist, he studied the mechanisms which control the division and shape of cells. In 2001, he was awarded the Nobel Prize for Physiology or Medicine for the discovery of the key protein regulators of the cell cycle. He has been Professor of Microbiology at the University of Oxford, CEO of the Imperial Cancer Research Fund and Cancer Research UK, and President of The Rockefeller University, New York. Since 2011, he has been Director and CEO of the Francis Crick Institute in London. Nurse has received the Royal Society’s Copley Medal (2005), the French Legion d’Honneur (2002), and is a Foreign Honorary Member of the American Academy of Arts and Sciences (2006). He was knighted in 1999 for services in cancer research and cell biology. For more information on the Science & Democracy Lecture Series, please visit the HKS STS website at http://sts.hks.harvard.edu/ USA USA Cambridge, Massachusetts, 02138 02138 Massachusetts, Massachusetts, Cambridge, Cambridge, 79 JFK Street Street JFK JFK 79 79 Center for the Environment the for Center School School Kennedy Kennedy Harvard Harvard Harvard University Harvard Society Society & & Technology Technology Science, Science, on on Program Program Program on Science, Technology & Society HARVARD KENNEDY SCHOOL HARVARD UNIVERSITY http://sts.hks.harvard.edu/.

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RANDY SCHEKMAN Department of Molecular and Cell Biology, Howard Hughes Medical Institute, University of California, Berkeley, USA
GENES AND PROTEINS THAT CONTROL THE SECRETORY PATHWAY Nobel Lecture, 7 December 2013 by RANDY SCHEKMAN Department of Molecular and Cell Biology, Howard Hughes Medical Institute, University of California, Berkeley, USA. Introduction George Palade shared the 1974 Nobel Prize with Albert Claude and Christian de Duve for their pioneering work in the characterization of organelles interrelated by the process of secretion in mammalian cells and tissues. These three scholars established the modern field of cell biology and the tools of cell fractionation and thin section transmission electron microscopy. It was Palade’s genius in particular that revealed the organization of the secretory pathway. He discovered the ribosome and showed that it was poised on the surface of the endoplasmic reticulum (ER) where it engaged in the vectorial translocation of newly synthesized secretory polypeptides (1). And in a most elegant and technically challenging investigation, his group employed radioactive amino acids in a pulse-chase regimen to show by autoradiograpic exposure of thin sections on a photographic emulsion that secretory proteins progress in sequence from the ER through the Golgi apparatus into secretory granules, which then discharge their cargo by membrane fusion at the cell surface (1). He documented the role of vesicles as carriers of cargo between compartments and he formulated the hypothesis that membranes template their own production rather than form by a process of de novo biogenesis (1). As a university student I was ignorant of the important developments in cell biology; however, I learned of Palade’s work during my first year of graduate school in the Stanford biochemistry department.
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Discovery of DNA Structure and Function: Watson and Crick By: Leslie A
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Cambridge's 92 Nobel Prize Winners Part 2 - 1951 to 1974: from Crick and Watson to Dorothy Hodgkin
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MCDB 5220 Methods and Logics April 21 2015 Marcelo Bassalo
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In 1953 in England James Watson and Francis Crick Discovered the Structure of DNA in the Now-Famous Scientific Narrative Known As the “Race Towards the Double Helix”
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Innate Immunity and Dendritic Cells in Kidney Disease and the Nobel Prize
EDITORIALS www.jasn.org Innate Immunity and Dendritic nately, Janeway died in 2003 and was no longer eligible to receive the prize. Cells in Kidney Disease and the The discoveries of Hoffmann and Janeway alerted immu- nologists all over the world to the possibility of a new signal- Nobel Prize ing pathway, and in 1998, Bruce Beutler and colleagues at the † Howard Hughes Medical Institute in Dallas first identified Hans-Joachim Anders* and Christian Kurts TLR4 as recognizing bacterial endotoxin.5 Beutler’s approach *Medizinische Poliklinik, Klinikum der Universita¨t Mu¨ nchen-LMU, Campus Innenstadt, Munich, Germany; and †Institutes of Molecu- was as clever as simple. He took advantage of two well-known lar Medicine and Experimental Immunology (IMMEI), University lipopolysaccharide-resistant mouse strains to map the newly Clinic of Bonn, Bonn, Germany discovered loci of the Toll genes. In doing so, he realized that J Am Soc Nephrol 22: ●●●–●●●, 2011. endotoxin resistance was linked to loss-of-function muta- doi: 10.1681/ASN.2011100975 tions in the Tlr4 gene. Two more circumstances encouraged researchers from many disciplines to rush into this new area of science, pro- On December 10, 2011, the Nobel Prize for Physiology or ducing more than 18,000 related publications within the last Medicine will honor the work of Jules Hoffmann, Bruce 15 years: first, Tlr4 mutant mice as well as suitable immuno- Beutler, and Ralph Steinman for their landmark discoveries stimulatory compounds, now discovered as agonists for dis- in the field of immunology. This recognition brings wide at- tinct TLRs, became available at relatively low costs to every- tention to a paradigm shift in understanding how multicel- one, and second, Shizou Akira, in Osaka, produced null mice lular organisms sense and interpret their external and inter- for most TLRs and many other related genes, and did not nal environments in maintaining homeostasis or initiating hesitate to share them with collaborators and competitors.
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James Watson and Francis Crick
James Watson and Francis Crick https://www.ducksters.com/biography/scientists/watson_and_crick.php biographyjameswatsonandfranciscrick.mp3 Occupation: Molecular biologists Born: Crick: June 8, 1916 Watson: April 6, 1928 Died: Crick: July 28, 2004 Watson: Still alive Best known for: Discovering the structure of DNA Biography: James Watson James Watson was born on April 6, 1928 in Chicago, Illinois. He was a very intelligent child. He graduated high school early and attended the University of Chicago at the age of fifteen. James loved birds and initially studied ornithology (the study of birds) at college. He later changed his specialty to genetics. In 1950, at the age of 22, Watson received his PhD in zoology from the University of Indiana. James Watson and Francis Crick https://www.ducksters.com/biography/scientists/watson_and_crick.php James D. Watson. Source: National Institutes of Health In 1951, Watson went to Cambridge, England to work in the Cavendish Laboratory in order to study the structure of DNA. There he met another scientist named Francis Crick. Watson and Crick found they had the same interests. They began working together. In 1953 they published the structure of the DNA molecule. This discovery became one of the most important scientific discoveries of the 20th century. Watson (along with Francis Crick, Rosalind Franklin, and Maurice Wilkins) was awarded the Nobel Prize in Physiology or Medicine in 1962 for the discovery of the DNA structure. He continued his research into genetics writing several textbooks as well as the bestselling book The Double Helix which chronicled the famous discovery. Watson later served as director of the Cold Spring Harbor Lab in New York where he led groundbreaking research into cancer.
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April 28 Sir Paul Nurse
MONDAY, APRIL 26th 8 pm We look forward to welcoming to Kenton SIR PAUL NURSE RATHER THAN GIVE A TALK, WE ARE VERY FORTUNATE IN THAT SIR PAUL IS HAPPY TO ANSWER QUESTIONS ON HIS EXTENSIVE CAREER AND HOBBIES PLEASE HAVE YOUR QUESTIONS READY OR SEND THEM IN BEFORE THE MEETING Paul Nurse is a geneticist and cell biologist who has worked on how the eukaryotic cell cycle is controlled. His major work has been on the cyclin dependent protein kinases and how they regulate cell reproduction. He is Director of the Francis Crick Institute in London, and has served as President of the Royal Society, Chief Executive of Cancer Research UK and President of Rockefeller University. He shared the 2001 Nobel Prize in Physiology or Medicine and has received the Albert Lasker Award, the Gairdner Award, the Louis Jeantet Prize and the Royal Society's Royal and Copley Medals. He was knighted by The Queen in 1999, received the Legion d'honneur in 2003 from France, and the Order of the Rising Sun in 2018 from Japan. He served for 15 years on the Council of Science and Technology, advising the Prime Minister and Cabinet, and is presently a Chief Scientific Advisor for the European Union. As well as his many medical accomplishments, amazingly Paul also has time to fly planes and engage in varied hobbies Paul flies gliders and vintage aeroplanes and has been a qualified bush pilot. He also likes the theatre, hill-walking, going to museums and art galleries, and running very slowly. All our Zoom sessions are available on the Kenton https://us02web.zoom.us/j/3531782577? YouTube channel: pwd=N0tlSWxxUGZmOEUrM1ZzclJFN1pzdz09 Kenton Shul In The Park Goes Live.
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