Insight from the Sociology of Science
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The Joys and Burdens of Our Heroes 12/05/2021
More Fun Than Fun: The Joys and Burdens of Our Heroes 12/05/2021 An iconic photo of Konrad Lorenz with his favourite geese. Photo: Willamette Biology, CC BY-SA 2.0 This article is part of the ‘More Fun Than Fun‘ column by Prof Raghavendra Gadagkar. He will explore interesting research papers or books and, while placing them in context, make them accessible to a wide readership. RAGHAVENDRA GADAGKAR Among the books I read as a teenager, two completely changed my life. One was The Double Helix by Nobel laureate James D. Watson. This book was inspiring at many levels and instantly got me addicted to molecular biology. The other was King Solomon’s Ring by Konrad Lorenz, soon to be a Nobel laureate. The study of animal behaviour so charmingly and unforgettably described by Lorenz kindled in me an eternal love for the subject. The circumstances in which I read these two books are etched in my mind and may have partly contributed to my enthusiasm for them and their subjects. The Double Helix was first published in London in 1968 when I was a pre-university student (equivalent to 11th grade) at St Joseph’s college in Bangalore and was planning to apply for the prestigious National Science Talent Search Scholarship. By then, I had heard of the discovery of the double-helical structure of DNA and its profound implications. I was also tickled that this momentous discovery was made in 1953, the year of my birth. I saw the announcement of Watson’s book on the notice board in the British Council Library, one of my frequent haunts. -
書 名 等 発行年 出版社 受賞年 備考 N1 Ueber Das Zustandekommen Der
書 名 等 発行年 出版社 受賞年 備考 Ueber das Zustandekommen der Diphtherie-immunitat und der Tetanus-Immunitat bei thieren / Emil Adolf N1 1890 Georg thieme 1901 von Behring N2 Diphtherie und tetanus immunitaet / Emil Adolf von Behring und Kitasato 19-- [Akitomo Matsuki] 1901 Malarial fever its cause, prevention and treatment containing full details for the use of travellers, University press of N3 1902 1902 sportsmen, soldiers, and residents in malarious places / by Ronald Ross liverpool Ueber die Anwendung von concentrirten chemischen Lichtstrahlen in der Medicin / von Prof. Dr. Niels N4 1899 F.C.W.Vogel 1903 Ryberg Finsen Mit 4 Abbildungen und 2 Tafeln Twenty-five years of objective study of the higher nervous activity (behaviour) of animals / Ivan N5 Petrovitch Pavlov ; translated and edited by W. Horsley Gantt ; with the collaboration of G. Volborth ; and c1928 International Publishing 1904 an introduction by Walter B. Cannon Conditioned reflexes : an investigation of the physiological activity of the cerebral cortex / by Ivan Oxford University N6 1927 1904 Petrovitch Pavlov ; translated and edited by G.V. Anrep Press N7 Die Ätiologie und die Bekämpfung der Tuberkulose / Robert Koch ; eingeleitet von M. Kirchner 1912 J.A.Barth 1905 N8 Neue Darstellung vom histologischen Bau des Centralnervensystems / von Santiago Ramón y Cajal 1893 Veit 1906 Traité des fiévres palustres : avec la description des microbes du paludisme / par Charles Louis Alphonse N9 1884 Octave Doin 1907 Laveran N10 Embryologie des Scorpions / von Ilya Ilyich Mechnikov 1870 Wilhelm Engelmann 1908 Immunität bei Infektionskrankheiten / Ilya Ilyich Mechnikov ; einzig autorisierte übersetzung von Julius N11 1902 Gustav Fischer 1908 Meyer Die experimentelle Chemotherapie der Spirillosen : Syphilis, Rückfallfieber, Hühnerspirillose, Frambösie / N12 1910 J.Springer 1908 von Paul Ehrlich und S. -
Discovery of DNA Structure and Function: Watson and Crick By: Leslie A
01/08/2018 Discovery of DNA Double Helix: Watson and Crick | Learn Science at Scitable NUCLEIC ACID STRUCTURE AND FUNCTION | Lead Editor: Bob Moss Discovery of DNA Structure and Function: Watson and Crick By: Leslie A. Pray, Ph.D. © 2008 Nature Education Citation: Pray, L. (2008) Discovery of DNA structure and function: Watson and Crick. Nature Education 1(1):100 The landmark ideas of Watson and Crick relied heavily on the work of other scientists. What did the duo actually discover? Aa Aa Aa Many people believe that American biologist James Watson and English physicist Francis Crick discovered DNA in the 1950s. In reality, this is not the case. Rather, DNA was first identified in the late 1860s by Swiss chemist Friedrich Miescher. Then, in the decades following Miescher's discovery, other scientists--notably, Phoebus Levene and Erwin Chargaff--carried out a series of research efforts that revealed additional details about the DNA molecule, including its primary chemical components and the ways in which they joined with one another. Without the scientific foundation provided by these pioneers, Watson and Crick may never have reached their groundbreaking conclusion of 1953: that the DNA molecule exists in the form of a three-dimensional double helix. The First Piece of the Puzzle: Miescher Discovers DNA Although few people realize it, 1869 was a landmark year in genetic research, because it was the year in which Swiss physiological chemist Friedrich Miescher first identified what he called "nuclein" inside the nuclei of human white blood cells. (The term "nuclein" was later changed to "nucleic acid" and eventually to "deoxyribonucleic acid," or "DNA.") Miescher's plan was to isolate and characterize not the nuclein (which nobody at that time realized existed) but instead the protein components of leukocytes (white blood cells). -
Cambridge's 92 Nobel Prize Winners Part 2 - 1951 to 1974: from Crick and Watson to Dorothy Hodgkin
Cambridge's 92 Nobel Prize winners part 2 - 1951 to 1974: from Crick and Watson to Dorothy Hodgkin By Cambridge News | Posted: January 18, 2016 By Adam Care The News has been rounding up all of Cambridge's 92 Nobel Laureates, celebrating over 100 years of scientific and social innovation. ADVERTISING In this installment we move from 1951 to 1974, a period which saw a host of dramatic breakthroughs, in biology, atomic science, the discovery of pulsars and theories of global trade. It's also a period which saw The Eagle pub come to national prominence and the appearance of the first female name in Cambridge University's long Nobel history. The Gender Pay Gap Sale! Shop Online to get 13.9% off From 8 - 11 March, get 13.9% off 1,000s of items, it highlights the pay gap between men & women in the UK. Shop the Gender Pay Gap Sale – now. Promoted by Oxfam 1. 1951 Ernest Walton, Trinity College: Nobel Prize in Physics, for using accelerated particles to study atomic nuclei 2. 1951 John Cockcroft, St John's / Churchill Colleges: Nobel Prize in Physics, for using accelerated particles to study atomic nuclei Walton and Cockcroft shared the 1951 physics prize after they famously 'split the atom' in Cambridge 1932, ushering in the nuclear age with their particle accelerator, the Cockcroft-Walton generator. In later years Walton returned to his native Ireland, as a fellow of Trinity College Dublin, while in 1951 Cockcroft became the first master of Churchill College, where he died 16 years later. 3. 1952 Archer Martin, Peterhouse: Nobel Prize in Chemistry, for developing partition chromatography 4. -
Introduction and Historical Perspective
Chapter 1 Introduction and Historical Perspective “ Nothing in biology makes sense except in the light of evolution. ” modified by the developmental history of the organism, Theodosius Dobzhansky its physiology – from cellular to systems levels – and by the social and physical environment. Finally, behaviors are shaped through evolutionary forces of natural selection OVERVIEW that optimize survival and reproduction ( Figure 1.1 ). Truly, the study of behavior provides us with a window through Behavioral genetics aims to understand the genetic which we can view much of biology. mechanisms that enable the nervous system to direct Understanding behaviors requires a multidisciplinary appropriate interactions between organisms and their perspective, with regulation of gene expression at its core. social and physical environments. Early scientific The emerging field of behavioral genetics is still taking explorations of animal behavior defined the fields shape and its boundaries are still being defined. Behavioral of experimental psychology and classical ethology. genetics has evolved through the merger of experimental Behavioral genetics has emerged as an interdisciplin- psychology and classical ethology with evolutionary biol- ary science at the interface of experimental psychology, ogy and genetics, and also incorporates aspects of neuro- classical ethology, genetics, and neuroscience. This science ( Figure 1.2 ). To gain a perspective on the current chapter provides a brief overview of the emergence of definition of this field, it is helpful -
Biography (Modified, After Festetics 1983)
Konrad Lorenz’s Biography (modified, after Festetics 1983) 1903: Konrad Zacharias Lorenz (KL) was born in Altenberg /Austria on Nov. 7 as the last of three children of Emma Lorenz and Dr. Adolf Lorenz, professor for orthopedics at the Medical branch of the University of Vienna. In the same year the representative and spacious Altenberg family home was finished. 1907: KL starts keeping animals, such as spotted newts in aquaria, raises some ducklings and is not pleased by his first experiences with a dachshound. Niko Tinbergen, his lifelong colleague and friend, is born on April 15 in Den Haag, The Netherlands. 1909: KL enters elementary school and engages in systematic studies in crustaceans. 1910: Oskar Heinroth, biologist and founder of "Vergleichende Verhaltensforschung" (comparative ethology) from Berlin and fatherlike scientific mentor of the young KL publishes his classical paper on the ethology of ducks. 1915: KL enters highschool (Schottengymnasium Wien), keeps and breeds songbirds. 1918: Wallace Craig publishes the comparative ethology of Columbidae (pigeons), a classics of late US biologist Charles O. Whitman, who was like O. Heinroth, a founding father of comparative ethology. 1921: KL excels in his final exams. Together with friend Bernhard Hellmann, he observes and experiments with aggression in a cichlid (Herichthys cyanoguttatum). This was the base for KL's psychohydraulic model of motivation. 1922: Father Adolf sends KL to New York to take 2 semesters of medicine courses at the ColumbiaUniversity, but mainly to interrupt the relationship of KL with longterm girlfriend Gretl Gebhart, his later wife. This paternal attempt to influence the mate choice of KL failed. -
2862 001 OCR DBL ZIP 0.Pdf
, , .- GREAT SCIENTIFIC EXPERIMENTS Twenty Experiments that Changed our View of the World ROM HARRE Oxford New York OXFORD UNIVERSITY PRESS 1983 Whi'te Oalt OXford Um'wrsity Press, Waftoff Street, OXfordOX'2 6DP LondonGlasgov) New Yorn Toronto Delhi &mbay Calcutta Madras Knrachi Kuala'LumpurSingapore HangKnng·Tokyo Nairobi Dar es Salaam Cape Town Mel~urne Auckland and associates in Beirut Berlin [hac/an Mexico City Nicosia © Phaidon Press limited 1981 First published by Phaidon Press Limited /981 First issued as an Oxford University Press Paperback 1983 All n'ghts reserved. No port of this publication may be reproduced, stored in a retrieval system, or transmitted, in any form or by atiy means, electronic, mechanical, photocopying, recording, or otherwise, without ., the prior permission oj Oxford University Press This book is sold subject to the condition that it shall n(Jt,~by way oftrade or otherwise, be Jent, re-sold, hired out or otheruxse circulated without the pilblisher's prior consent in any fonn of binding or cover other than that in which it is published and ulithout a similar condition including this condition being imposed on the subsequent purchaser British Library Cataloguing in Publication Data Ham, Rom Great scientific experiments.-{Oxford paperbacks) 1. Science-experiments-History 1. Title SfJ1'.24 Q125 ISBN 0-19-286036-4 library of Congress Cataloging in Publication Data , Harrl, Rmnimo. Great scientific experimetus. (Oxford paperbacks) " Biblwgraphy: p. Includes index. 1. Scieni:e-MethodlJ~(Ue studies. 2.-Science-Expen"men/$-PhI1osopf!y. 3. Science-Histo1y--Sources. 4. Scientists_Biograpf!y. I. Title. QI75.H32541983 507'.2 82';'19035 ISBN 0-19-286036-4 (pbk.) Printed in Great Britain by R. -
Synapses, Sea Slugs, and Psychiatry
J Neurol Neurosurg Psychiatry 2001;70:1–3 1 J Neurol Neurosurg Psychiatry: first published as 10.1136/jnnp.70.1.1 on 1 January 2001. Downloaded from EDITORIAL Synapses, sea slugs, and psychiatry This year’s Nobel Prize in physiology or medicine, announced literature than medicine. However, his Austrian contempo- on 9 October 2000, has gone to Arvid Carlsson, Paul Green- rary, Wagner von Jauregg, became the first psychiatrist lau- gard, and Eric Kandel. The citation states that the prize is reate in 1927 for his observations on the beneficial eVects shared for pioneering discoveries in slow synaptic transmis- of induced fever (for example, malaria) on the symptoms of sion, which are “crucial for an understanding of how the nor- neurosyphillis—not, it has to be said, a treatment that has mal functioning of the brain and how disturbances in this sig- stood the test of time. But European psychiatry at the fin de nal can give rise to neurological and psychiatric diseases” siecle was resolutely biological. Egaz Moniz, the Portu- (www.nobel.se/announcement/2000/medicine.html). Carls- guese neurosurgeon who developed psychosurgery, shared son proved the importance of dopamine as a neurotransmitter the prize in 1949, although the invention of arterial angio- and subsequently its role in Parkinson’s disease and graphy was perhaps a more enduring legacy. Neuroscien- schizophrenia. The strongest pillar of the dopamine theory of tists have been so rewarded on many occasions—but as in schizophrenia is the linear relation between potency of anti- this year, the contributions tended to be at the “basic” psychotic drugs and their dopamine antagonist potential. -
MCDB 5220 Methods and Logics April 21 2015 Marcelo Bassalo
Cracking the Genetic Code MCDB 5220 Methods and Logics April 21 2015 Marcelo Bassalo The DNA Saga… so far Important contributions for cracking the genetic code: • The “transforming principle” (1928) Frederick Griffith The DNA Saga… so far Important contributions for cracking the genetic code: • The “transforming principle” (1928) • The nature of the transforming principle: DNA (1944 - 1952) Oswald Avery Alfred Hershey Martha Chase The DNA Saga… so far Important contributions for cracking the genetic code: • The “transforming principle” (1928) • The nature of the transforming principle: DNA (1944 - 1952) • X-ray diffraction and the structure of proteins (1951) Linus Carl Pauling The DNA Saga… so far Important contributions for cracking the genetic code: • The “transforming principle” (1928) • The nature of the transforming principle: DNA (1944 - 1952) • X-ray diffraction and the structure of proteins (1951) • The structure of DNA (1953) James Watson and Francis Crick The DNA Saga… so far Important contributions for cracking the genetic code: • The “transforming principle” (1928) • The nature of the transforming principle: DNA (1944 - 1952) • X-ray diffraction and the structure of proteins (1951) • The structure of DNA (1953) How is DNA (4 nucleotides) the genetic material while proteins (20 amino acids) are the building blocks? ? DNA Protein ? The Coding Craze ? DNA Protein What was already known? • DNA resides inside the nucleus - DNA is not the carrier • Protein synthesis occur in the cytoplasm through ribosomes {• Only RNA is associated with ribosomes (no DNA) - rRNA is not the carrier { • Ribosomal RNA (rRNA) was a homogeneous population The “messenger RNA” hypothesis François Jacob Jacques Monod The Coding Craze ? DNA RNA Protein RNA Tie Club Table from Wikipedia The Coding Craze Who won the race Marshall Nirenberg J. -
Nikolaas Tinbergen: the Careful Scientist), Respectively, by Sindhu Radhakrishna in This Issue
Editorial T N C Vidya, Associate Editor We are happy to bring to you, an issue that celebrates Niko- laas Tinbergen, who along with Konrad Lorenz and Karl von Frisch, laid the foundations of the field of ethology, the study of animal behaviour. In the late 19th and early 20th centuries, animal behaviour was largely approached either through vital- ism and purposive psychology (in England and then America), suggesting that behaviour was the outcome of mystical forces Email: within individuals that could, therefore, not be explained through [email protected] physico-chemical processes, or through comparative psychology (in America) that placed an almost exclusive emphasis on learn- ing as the process responsible for behaviour. Comparative psy- chologists at that time often anthropomorphised animal behaviour and relied on laboratory experiments to test animals. Ethologists Lorenz, Tinbergen, and von Frisch (in Europe), on the other hand, articulated how animal behaviour itself could be an evolved phe- nomenon. The behaviour showed by an animal could, therefore, be inherited, have survival value, and be acted upon by natu- ral selection. This was in contrast to the view of comparative psychologists who thought that mental faculties – and not be- haviours – evolved and allowed various species to learn appro- priate behaviours. Therefore, ethologists tended to focus on an- imal behaviour in the natural environment and study instinctive behaviours – behaviours that animals displayed in response to specific stimuli even in the absence of prior experience. How- ever, they realized that learning could also be important in some species at least. Lorenz, Tinbergen, and von Frisch carried out careful observations and experiments on insects, fishes, and birds. -
In 1953 in England James Watson and Francis Crick Discovered the Structure of DNA in the Now-Famous Scientific Narrative Known As the “Race Towards the Double Helix”
THE NARRATIVES OF SCIENCE: LITERARY THEORY AND DISCOVERY IN MOLECULAR BIOLOGY PRIYA VENKATESAN In 1953 in England James Watson and Francis Crick discovered the structure of DNA in the now-famous scientific narrative known as the “race towards the double helix”. Meanwhile in France, Roland Barthes published his first book, Writing Degree Zero, on literary theory, which became the intellectual precursor for the new human sciences that were developing based on Saussurean linguistics. The discovery by Watson and Crick of the double helix marked a definitive turning point in the development of the life sciences, paving the way for the articulation of the genetic code and the emergence of molecular biology. The publication by Barthes was no less significant, since it served as an exemplar for elucidating how literary narratives are structured and for formulating how textual material is constructed. As Françoise Dosse notes, Writing Degree Zero “received unanimous acclaim and quickly became a symptom of new literary demands, a break with tradition”.1 Both the work of Roland Barthes and Watson and Crick served as paradigms in their respective fields. Semiotics, the field of textual analysis as developed by Barthes in Writing Degree Zero, offered a new direction in the structuring of narrative whereby each distinct unit in a story formed a “code” or “isotopy” that categorizes the formal elements of the story. The historical concurrence of the discovery of the double helix and the publication of Writing Degree Zero may be mere coincidence, but this essay is an exploration of the intellectual influence that both events may have had on each other, since both the discovery of the double helix and Barthes’ publication gave expression to the new forms of knowledge 1 Françoise Dosse, History of Structuralism: The Rising Sign, 1945-1966, trans. -
James Watson and Francis Crick
James Watson and Francis Crick https://www.ducksters.com/biography/scientists/watson_and_crick.php biographyjameswatsonandfranciscrick.mp3 Occupation: Molecular biologists Born: Crick: June 8, 1916 Watson: April 6, 1928 Died: Crick: July 28, 2004 Watson: Still alive Best known for: Discovering the structure of DNA Biography: James Watson James Watson was born on April 6, 1928 in Chicago, Illinois. He was a very intelligent child. He graduated high school early and attended the University of Chicago at the age of fifteen. James loved birds and initially studied ornithology (the study of birds) at college. He later changed his specialty to genetics. In 1950, at the age of 22, Watson received his PhD in zoology from the University of Indiana. James Watson and Francis Crick https://www.ducksters.com/biography/scientists/watson_and_crick.php James D. Watson. Source: National Institutes of Health In 1951, Watson went to Cambridge, England to work in the Cavendish Laboratory in order to study the structure of DNA. There he met another scientist named Francis Crick. Watson and Crick found they had the same interests. They began working together. In 1953 they published the structure of the DNA molecule. This discovery became one of the most important scientific discoveries of the 20th century. Watson (along with Francis Crick, Rosalind Franklin, and Maurice Wilkins) was awarded the Nobel Prize in Physiology or Medicine in 1962 for the discovery of the DNA structure. He continued his research into genetics writing several textbooks as well as the bestselling book The Double Helix which chronicled the famous discovery. Watson later served as director of the Cold Spring Harbor Lab in New York where he led groundbreaking research into cancer.