Nihonbashi Honcho 2-3-11, Nihonbashi Life Science Building 10th Floor, Chuo-ku, Tokyo 103-0023, Japan Phone (within(within Japan):Japan): 03-3241-4911; 03-3241-4911; Phone Phone (outside (outside Japan): Japan): +81-3-3241-4911 +81-3-3241-4911, Fax Fax (within (within Japan): Japan): 03-3241-3757; 03-3241-3757; Fax (outsideFax (outside Japan): Japan): +81-3-3241-3757 +81-3-3241-3757 (Monday-Friday (Monday-Friday 9:00-17:00) 9:00-17:00) Website: Website: www.link-j.org www.link-j.org

Published: Jul. 1, 2020 Building Ecosystem to Create Innovation in Life Science

LINK-J (Life Science Innovation Network Japan) builds platforms centered in Nihonbashi, Tokyo for networking Nihonbashi has been Tokyo’s pharmaceutical and exchanging information with people around the world. We serve people involved in life science research and its industry in the broad sense including preventative, presymptomatic and health and longevity medicine district for 400 years such as regenerative medicine, precision medicine, drug development, medical devices and healthcare IT. LINK-J is headquartered in Nihonbashi, the historic area of Tokyo where Japan’s leading pharmaceutical By encouraging the activation and creation of an innovative life science industry in Japan and the world, we companies have had headquarters for the past 400 years and where expertise in the life sciences contribute to the larger vision of a society where we can live healthily and happily. comes together. Nihonbashi is located in central Tokyo, where information, people and investors meet from all over the world. Visitors enjoy the urban environment which gives them access to many commercial and lodging facilities. We Meet with key operators. Attend events & programs create and distribute information from Nihonbashi, this historically and geographically unique place. to aid product development of your concepts.

Guide and Support Pharmaceutical Campanies

Network and Collaborate Financial Institutes Daiichi Sankyo

LINK-J Nihonbashi- Life Science Bldg Facilities Muromachi Mitsui Tower Takeda Astellas

Bank of Japan

Chugai Chuo Street Astellas Take off Grow Life Science Hub Connect Come Together Matching and pitching events for Acceleration funding procurement programs for and alliance building Metropolitan Expressway Nihonbashi entrepreneurs and Networking events startups Nomura Securities for various subfields within the life science Promoting field Tokyo Stock Bank of America Exchange collaboration between Merrill Lynch members and various international organizations TOKYO STATION

1 2 Large Symposiums

We organize symposiums with 300-500 attendees throughout the year. We invite leaders in the field to discuss wide-ranging issues related to regenerative medicine, AI, medical devices, genomes, cancer, etc. EVENTS & • Industry-Government-Academia Regenerative Medicine Symposium (2016 - ) • AI × Life Science Symposium (2017) • Possibilities of Genome: The Challenge to Create a New Industry PROGRAMS (2018) • Innovation in Cancer Medicine (2019)

Networkings

We host evening networking events with our LINK-J Supporters, who are entrepreneurs and experienced professionals in the fields of research and development, management, law and finance. We also host and co-host many global-scale events and receptions with international universities and corporations such as UC San LINK-J creates networking and collaboration Diego and many European and North American organizations. opportunities (Steps 1 & 2) and guiding and supporting Networking Events (Steps 3 & 4) activities to build an ecosystem that - UCSD fosters innovation. 510 + Events/years - UCLA - Princeton University We help commercialize or develop ideas and Seminars with Embassies and Governments concepts into products by organically connecting key - San Diego players in the life sciences field such as startups, large - Queensland, Australia corporations, academia and venture capital through - Sweden organizing events and programs. - Israel

Business Tours

We regularly host tours to visit the world’s life science clusters. You can experience each region’s cutting-edge research and network. • Singapore Life Science Business Tour • Eurobiomed Southern France Business Tour • San Diego Tour

Acceleration Programs

We administer programs such as “Out of Box Consulting Room” to discuss research concepts for free and “SAND BOX” which creates results through collaboration of a collective of students and young people from diverse backgrounds. We also organize our own pitch contest as well as co-sponsor entrepreneurial support programs hosted by venture capitals and accelerators with complementary agendas such as ZENTECH DOJO NIHONBASHI” (Sponsor: Indee Japan) and “BRAVE” (Sponsor: Beyond Next Ventures).

3 4 Number of members, demographics 434 in Total

IP and legal: 2% Medical and social A wide range of key players from industry, government, services: 1% Others: 5% and academia have joined us. Fields represented include pharmaceuticals, regenerative medicine, medical devices, VC: 5% Biomed and education and research, healthcare services, consulting, venture pharmaceutical: capital, intellectual property and law. Medical and Regenerative testing devices medicine: 9% 34% MEMBERS Membership A 49 Medical IT Membership B 245 services 12% Support for Membership C 140 commercialization Education and Consulting19% research 13% Membership types

There are 3 types of LINK-J memberships: A, B, C. Membership A is for corporations with 100+ employees. Membership B is for corporations with up to 100 employees including startups and non-profit organizations (Universities, Research institute). Membership C is for individuals. The A and B memberships allow for the member organizations to use the conference rooms and temporary Top players of the life science field all over the world working rooms for hosting meetings, events and receptions. are joining LINK-J. You can benefit by joining this network and becoming a part of our community. 430+ Members Membership A Membership B Membership C (Corporations) (Corporations and NPOs) (Individuals)

· Individuals such as doctors · Corporations with up to 100 · Employees and providers of employees corporations and organizations Corporations with 100+ employees · Non-profit organizations · Employees and providers of (Universities, Research institute) non-profit organizations · College and graduate students Entrance fee: 100,000 yen Entrance fee: 30,000 yen Entrance fee: 2,000 yen Membership fee: 500,000 yen Membership fee: 120,000 yen Membership fee: 3,000-30,000 yen

Benefit

Events and Programs (members’ special prices)

Networking

Consulting by LINK-J Supporters

Use of the LINK-J Exclusive Communication Lounge (Complimentary)

Use of the Service Office (Separate contacts applyed)

Events and programs notification service on the LINK-J website and via e-mail

Publication on the homepage, brochure, etc.

Private use of the exclusive LINK-J communication lounge (Members Price)

Use of the conference room or temporary working room (Members Price)

5 6 Domestic and International Collaborations

We have agreed on partnering with 11 organizations including universities around the world. We collaborate through hosting programs and events, exchanging publications, materials and information, providing services to each other’s members, visiting, joint hosting and/or sponsorship of activities and collaborating on advertisements. COLLABORATIONS

One Nucleus MedCity Institute for Advanced Biosciences, University of California, Los Angeles Keio University Eurobiomed Kawasaki City BIOCOM Yokohama City

University of California, San Diego Kyoto Research Park Foundation for Biomedical Research and Innovation at Kobe

LINK-J will continue to provide valuable information and increased chances for networking in collaboration with renowned institutions, organizations and universities across the world. 11 Collaborations

Date of MOU signed Name of organization

May 2016 University of California, San Diego (UCSD), USA

May 2016 BIOCOM, USA

June 2017 Eurobiomed, France

July 2017 Kyoto Research Park, Corp., Japan

December 2017 One Nucleus, UK

Foundation for Biomedical Research and Innovation at January 2018 Kobe, Japan

Institute for Advanced Biosciences, Keio University, April 2018 Japan

June 2018 MedCity, UK

August 2018 City of Kawasaki, Japan

June 2019 University of California, Los Angeles (UCLA), USA

August 2019 City of Yokohama, Japan

7 8 Board members

Chairman of Chairman, Graduate School of Medicine, Keio University / Professor, Department of Physiology, Hideyuki Okano, M.D., Ph.D. the Board Graduate School of Medicine, Keio University Vice Chairman Yoshiki Sawa, M.D., Ph.D. Professor, Department of Cardiovascular Surgery, Osaka University Graduate School of Medicine of the Board Director Takashi Ueda Executive Managing Officer, Mitsui Fudosan Co., Ltd. Director Akihiko Soyama President and Chief Executive Officer of Life Science Innovation Network Japan Auditor Yutaro Kikuchi Director, Kikuchi Sogo Law Office ORGANIZATIONS Auditor Shigeru Sugimoto Managing Partner, Sakura & Co. Management Advisory Committee

Special Advisor Yoichiro Matsumoto, Dr. Eng. President, Tokyo University of Science Special Advisor Shinya Yamanaka, M.D., Director and Professor, Center for iPS Cell Research and Application (CiRA) Kyoto University; Nobel Ph.D. laureate in Physiology / Medicine Special Advisor Peter F. Cowhey, Ph.D. Dean, School of Global Policy & Strategy, University of California, San Diego Advisor Shinji Asonuma Executive Vice-President for Industry-Government-Academia Collaboration, Kyoto University Advisor Hironori Kasahara, Ph.D. Senior Executive Vice President for Research and IT Promotion, Waseda University Advisor Hidetoshi Kotera Executive Director, RIKEN Advisor Isao Teshirogi, Ph.D. President, The Federation of Pharmaceutical Manufacturers' Associations of JAPAN (FPMAJ) / President and CEO of Shionogi & Co., Ltd. Advisor George Nakayama President, Japan Pharmaceutical Manufacturers Association (JPMA) / Chairman and CEO, Daiichi Sankyo Co., Ltd. Advisor Ken-ichiro Hata, D.D.S., Ph.D. Chairman, Forum for Innovative Regenerative Medicine (FIRM) / President and CEO, Japan Tissue Our activities are supported by management advisory Engineering Co., Ltd. (J-TEC) committee members and supporters who possess Advisor Toshiaki Higashihara President & CEO, Hitachi, Ltd. specialized expertise and experience. Advisor Kenichi Matsumoto Chairman, the Japan Federation of Medical Devices Associations / Chairman, Sakura Global Holding Co., Ltd + Advisor Masaaki Mizuno, M.D., Ph.D. Director and Clinical Professor, Center for Advanced Medicine and Clinical Research, Department of The management advisory committee is composed 35 Supporters Advanced Medicine, Nagoya University Hospital of industry leaders who strongly support us with their Advisor Yoshinori Yajima Director, Office of Cooperative Research and Development, Tohoku University Advisor Toshiya Watanabe, Ph.D. Professor, Institute for Future Initiatives, University of Tokyo broad-based knowledge and experience. They also Advisor Masanobu Komoda President and CEO, Mitsui Fudosan Co., Ltd. offer strategic advice to the Board of Directors. LINK-J has recruited a number of supporters, people Supporters with knowledge spanning diverse fields and whose skill sets range from research and development to Masanori Akita MTI Ltd. Toru J. Seo, Ph.D. Pfizer Japan Inc. Tsuyoshi Ito Beyond Next Ventures Tohru Takashi, Ph.D. Japan Agency for Medical Research and management, law, and finance. Our supporters, who Development include entrepreneurs and experts, participate in many Taro Inaba REMIGES Ventures Shunichi Takahashi, Ph.D. Bayer Yakuhin, Ltd. of the events that we put together and offer one-on-one Yo Iwami, M.D., Ph.D. MedPeer, Inc. Koichiro Tsujimaru, Ph.D. Tsujimaru International Patent Office Atsushi Usami, Ph.D. The University of Tokyo Edge Capital Co., Ltd. Shingo Tsuda INDEE Japan Ltd. advice to LINK-J special members. Takahiro Uchida, M.D. Japanese Organization for Medical Device Takuma Nakatsuka POC Clinical Research Inc. Ph.D., MSc. Development, Inc. Hajime Oshita MedVenture Partners, Inc. Shogo Nishida Boston Consulting Group Jun Otomo, Ph.D. Hitachi, Ltd. Takato Noumi, Ph.D. FORESIGHT & LINX K.K. Hardy TS Kagimoto, M.D. Healios K.K. Nobuhiko Hibara, Ph.D. Waseda Business School Hiroaki Kato, M.D. Aillis Inc. Ryuji Hiramatsu, Ph.D. Foundation for Biomedical Research and Innovation at Kobe Hiroyuki Kanoh Forum for Innovative Regenerative Medicine Kinji Fuchikami Mitsui & Co. Global Investment, Inc.

Tomy Kamada, Ph.D. TomyK Ltd. Ikkei Matsuda, Ph.D., MBA Science, Art & Research for Reconstruction (SARR)

Makio Kitazawa Boston Consulting Group Masashi Matsunaga, Ph.D. Biospire Japan, Ltd. Hiroaki Kitano, Ph.D. Sony Computer Science Laboratories Keita Mori SanBio Company Limited

Takashi Kiyoizumi, M.D., Ph.D. University of California, San Diego (UCSD) Daiki Moriyama Deloitte Tohmatsu Venture Support Co., Ltd. Masashi Kiyomine Kicker Ventures Yuji Yamamoto, M.D., MBA MinaCare Co., Ltd. Yohei Sawayama Coral Capital Masayuki Yokota Tokyo Stock Exchange, Inc. Aki Shimauchi INDEE Medical, Inc. Hayato Watanabe, CFA Locust Walk Japan, LLC Tsutomu Sugaya Nobelpharma Co., Ltd. Ulrike Schaede, Ph.D. University of California, San Diego (UCSD)

9 10 Conference Rooms

There are various sized rooms that can be used for meetings, lectures, seminars, happy hours, special events, etc. These spaces are also equipped with sound and audio-visual facilities necessary for presentations. (Some incur extra charges)

• Nihonbashi Life Science Hub FACILITIES • Nihonbashi Life Science Building (B1, 2, 3, 9 and 10th floors) • Nihonbashi Life Science Building 2 (9th floor)

Communication Lounges

The LINK-J Communication Lounge is exclusively for members. There are books, complementary drinks and snacks for sale in the members-only area. The 10th floor lounge in Nihonbashi Life Science Building and foyer area of the Nihonbashi Life Science Hub is available for meets- and-greets, receptions, etc.

• Nihonbashi Life Science Hub • Nihonbashi Life Science Building (1st and 10th floors) We operate conference rooms and communication • Ueno Building (8th floor) lounges for the exclusive use of LINK-J members located in the middle of Nihonbashi, an easily accessible center of business. We help you build a new network 9+ buildings Temporary Working Rooms and create your new business in a bright and open atmosphere. On the 3rd floor of the Nihonbashi Life Science Building, there is a space that can be reserved for up to 7 days on a per-day basis.

Serviced Offices

We offer a wide-range of possibilities from secured individual booths to open desks and are pleased to accommodate your needs. You can also register this location as your office. This space is also furnished and does not require a deposit allowing you to keep your startup fees low. • 5th floor, Nihonbashi Life Science Building • 8th floor, Tosho Building • 8th floor Ueno Building

Offices

We rent out small to large sized offices to adjust to the size of your business. • Nihonbashi Life Science Building • Nihonbashi Life Science Building 2 • MFPR Nihonbashi Honcho Building • Ueno Building • LAUNCH Nihonbashi Ningyocho • Fukushima Building • Nihonbashi Honcho 3-Chome Building

11 12 Location:

Life Science Innovation Network Japan (LINK-J)

Address:Nihonbashi Honcho 2-3-11, Nihonbashi Life Science Building 10th Floor, Chuo-ku, Tokyo 103-0023, Japan Phone (within Japan): 03-3241-4911; Phone (outside Japan): +81-3-3241-4911 Fax (within Japan): 03-3241-3757; Fax (outside Japan): +81-3-3241-3757

Nihonbashi Life Science Locations

Shuto Expressway Route No. 1 Ueno Line Tokyo Metro Ginza Line Exit 4 ACCESS Exit 1 Tokyo Metro Hibiya Line Showa-dori Street Kodenmacho Station Exit 3

④Tosho Seijo IshiiIshiiSeijo Building Sobu Line ⑨ Nihonbashi Honcho 3-Chome Building Honcho Exit 8 ③ JR Sobu Rapid Line Exit 6 Nihonbashi Life Science Building 2 Shin-Nihonbashi Station Exit 5 Tokyo Metro Hibiya Line Exit 4 ⑤ MFPR Nihonbashi Honcho Building Exit 2 Edo-dori Street Suginomori Shrine Daiichi Sankyo Headquarters NOF Horidomecho Chuo-dori Street Nihonbashi Honcho Building Underpass

Nihonbashi Muromachi ① Nihonbashi Life Science Building Mitsui Tower Exit A10

Exit A9 Doutor ■■Doutor Doutor ■■Doutor ⑥ Ueno Building YUITOYUITO Lawson ■■Lawson Nihonbashi Astellas Nihonbashi Life Science Facilites are located in a Exit A8 Fukutoku Shrine ■ Mitsui Building Starbucks convenient location that is about a 10-minute walk from Tokyo Metro Ginza Line Honcho 2-chome Tokyo Metro Hibiya Line Mitsukoshi-mae Station Exit A6 COREDO Ningyocho Station Muromachi 2 Horidome Children’s Park Tokyo station and is accessible with many subway lines. Nihonbashi COREDO Exit A4 Mitsui Tower Muromachi 1 Exit A7 ② Nihonbashi Life Science Hub ⑦ Nihonbashi is also a place with a high concentration of Bank of Japan (Muromachi Chibagin Mitsui Building 8th floor) LAUNCH Nihonbashi Ningyocho Exit A5 Mitsui Main building commercial facilities with many historic buildings while COREDO Muromachi 3 Exit A5 ⑧ Fukushima Building Toei Subway Asakusa Line Ningyocho Station being a robust hub of business activities. Exit A4 Mitsukoshi Main building Seven-Eleven ■ We invite you to creatively innovate with us! Exit A3 Tokyo Metro Hanzomon Line Exit A1 Mitsukoshi-mae Station Mitsukoshi Annex building ■ Seven-Eleven Exit A2 Toei Subway Asakusa Line Exit B4 Tokyo Metro Hanzomon Line Edobashi-kita

① ② ③ ④ ⑤ ⑥ ⑦ ⑧ ⑨

① Nihonbashi Life Science Building (LSB) Nihonbashi Honcho 2-3-11, Chuo-ku, Tokyo 103–0023 A 3-minute walk from Exit A6 of the “Mitsukoshi-mae” station on the Tokyo Metro LINK-J Headquarters Ginza and Hanzomon lines A 2-minute walk from Exit No. 5 of the “Shin-nihonbashi” station on the JR Sobu Rapid Line ② Nihonbashi Life Science Hub (HUB) Nihonbashi Muromachi 1-5-5, Chuo-ku, Tokyo 103–0022 Directly connected to “Mitsukoshi-mae” station on the Tokyo Metro Ginza and Hanzomon lines Directly connected to “Shin-nihonbashi” station on the JR Sobu Rapid Line ③ Nihonbashi Life Science Building 2 (LSB2) Nihonbashi Honcho 3-11-5, Chuo-ku, Tokyo 103–0023 ④ Tosho Building Nihonbashi Honcho 3-8-3, Chuo-ku, Tokyo 103–0023 ⑤ MFPR Nihonbashi Honcho Building Nihonbashi Honcho 3-7-2, Chuo-ku, Tokyo 103–0023 ⑥ Ueno Building Nihonbashi Horidomecho 1-9-10, Chuo-ku, Tokyo 103–0012 ⑦ LAUNCH Nihonbashi Ningyocho Nihonbashi Ningyocho 3-7-6, Chuo-ku, Tokyo 103–0013 ⑧ Fukushima Building Nihonbashi Muromachi 1-5-3, Chuo-ku, Tokyo 103–0022 ⑨ Nihonbashi Honcho 3-Chome Building Nihonbashi Honcho 3-8-5, Chuo-ku, Tokyo 103–0023

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