Nihonbashi Honchomuromachi 2-3-11, 3-3-9, Nihonbashi Life IT ScienceBuilding Building 2th Floor, 10th Chuo-ku, Floor, Chuo-ku, 103 Tokyo-0022 103, -0023, Japan Phone (within(within Japan):Japan): 03-3241-4911; 03-3241-4911; Phone Phone (outside (outside Japan): Japan): +81-3-3241-4911 +81-3-3241-4911, Fax Fax (within (within Japan): Japan): 03-3241-3757; 03-3241-3757; Fax (outsideFax (outside Japan): Japan): +81-3-3241-3757 +81-3-3241-3757 (Monday-Friday (Monday-Friday 9:00-17:00) 9:00-17:00) Website: Website: www.link-j.org www.link-j.org

Published: Oct. 1, 2020 Building Ecosystem to Create Innovation in Life Science

LINK-J (Life Science Innovation Network Japan) builds platforms centered in Nihonbashi for networking and Tokyo Nihonbashi and Doshomachi exchanging information with people around the world. We serve people involved in life science research and its industry in the broad sense including preventative, presymptomatic and health and longevity medicine such have been pharmaceutical district for 400 years as regenerative medicine, precision medicine, drug development, medical devices and healthcare IT. LINK-J is headquartered in Tokyo Nihonbashi, the historic area of Tokyo where Japan’s leading pharmaceutical By encouraging the activation and creation of an innovative life science industry in Japan and the world, we companies have had headquarters for the past 400 years and where expertise in the life sciences comes contribute to the larger vision of a society where we can live healthily and happily. together.

Nippon Chemiphar Bakuroyokoyama Sta. Nihonbashi is located in central Kanda Tokyo Nihonbashi Sta. Ono Tokyo, where information, Meet with key operators. Attend events & programs Kowa Kodemmacho Sta. Torii people and investors meet Ayumi Tosho Building Nihonbashi Honcho 3-Chome Building Daiichi Snakyo from all over the world. Visitors to aid product development of your concepts. MFPR Nihonbashi Honcho Building Senju Kracie Wakamoto enjoy the urban environment

Nihonbashi Life Science Building2 Takeda which gives them access to Alfresa Building Novo Nordisk Nihonbashi many commercial and lodging Muromachi Nihonbashi Life Science Building Guide and Support Tower Teikoku Astellas facilities. We create and LAUNCH Building Fuso Network and Collaborate Head Office distribute information from Ningyocho Sta. Santen Zeria Chugai Nihonbashi, this historically Toray Nihonbashi Life Science Hub Fukushima Building and geographically unique -mae Mitsubishi Tanabe Sta. place. Kissei

Biogen Japan

Take off COREDO 日本橋 Grow Nihonbashi Sta. Pharmaceutical Companies Connect TOKYO AstraZeneca Come Together Station LINK-J Facilities Matching and pitching events for Acceleration funding procurement Nippon Shinyaku Kayabacho Sta. Many Japanese representative Kita-shinchi Sta. programs for and alliance building Osaka Doshomachi entrepreneurs and pharmaceutical companies have their Bayer Networking events Fukushima Sta. startups roots in Osaka Doshomachi. There are for various subfields Toray also many excellent life sciences related Kyorin Oebashi Sta. within the life science GlaxoSmithKline Osaka City Hall Promoting field universities and research organizations Naniwabashi Sta. collaboration between Astellas Yodoyabashi Sta. in this area. Pharma members and Nippon Shinyaku Higobashi Shionogi Kitahama Sta. LINK-J further accelerate the real Sta. Ono various international Kissei Nihon organizations Teikoku exchange between people across Fuso Ayumi fields in this area where a variety of Takeda Nippon Zoki life sciences related businesses, such as Torii Sumitomo Dainippon Merck KGaA, Darmstadt, Germany Mitsubishi Tanabe pharmaceuticals, medical equipment, Senju Lifescience HUB West Otsuka Nippon Chemiphar regenerative medicine, and health Kowa related services, are being developed Asuka Honmachi Sta. Sakaisuji Honmachi Sta. through the mutual cooperation between Awaza Sta. Mochida industry, academia, and government.

Map of Japan Pharmaceutical Manufacturers Association member organizations and companies.

Hisamitsu

1 2 Large Symposiums

We organize symposiums with 300-500 attendees throughout the year. We invite leaders in the field to discuss wide-ranging issues related to regenerative medicine, AI, medical devices, genomes, cancer, etc. EVENTS & • Industry-Government-Academia Regenerative Medicine Symposium (2016 - ) • AI × Life Science Symposium (2017) • Possibilities of Genome: The Challenge to Create a New Industry PROGRAMS (2018) • Innovation in Cancer Medicine (2019)

Networkings

We host evening networking events with our LINK-J Supporters, who are entrepreneurs and experienced professionals in the fields of research and development, management, law and finance. We also host and co-host many global-scale events and receptions with international universities and corporations such as UC San LINK-J creates networking and collaboration Diego and many European and North American organizations. opportunities (Steps 1 & 2) and guiding and supporting Networking Events (Steps 3 & 4) activities to build an ecosystem that - UCSD fosters innovation. 510 + Events/years - UCLA - Princeton University We help commercialize or develop ideas and Seminars with Embassies and Governments concepts into products by organically connecting key - San Diego players in the life sciences field such as startups, large - Queensland, Australia corporations, academia and venture capital through - Sweden organizing events and programs. - Israel

Business Tours

We regularly host tours to visit the world’s life science clusters. You can experience each region’s cutting-edge research and network. • Singapore Life Science Business Tour • Eurobiomed Southern France Business Tour • San Diego Tour

Acceleration Programs

We administer programs such as “Out of Box Consulting Room” to discuss research concepts for free and “SAND BOX” which creates results through collaboration of a collective of students and young people from diverse backgrounds. We also organize our own pitch contest as well as co-sponsor entrepreneurial support programs hosted by venture capitals and accelerators with complementary agendas such as ZENTECH DOJO NIHONBASHI” (Sponsor: INDEE Japan) and “BRAVE” (Sponsor: Beyond Next Ventures).

3 4 Number of members, demographics 448 in Total

IP and legal: 2% Medical and social A wide range of key players from industry, government, services: 2% Others: 5%

and academia have joined us. Fields represented include VC: 4% pharmaceuticals, regenerative medicine, medical devices, Biomed and education and research, healthcare services, consulting, venture pharmaceutical: capital, intellectual property and law.(as of Sept.24 2020) Medical and Regenerative testing devices medicine: 10% 34% MEMBERS Membership A Medical IT 55 services Membership B 258 11% Membership C Education and Support for 135 research 12% commercialization Consulting 20%

Membership types

There are 3 types of LINK-J memberships: A, B, C. Membership A is for corporations with 100+ employees. Membership B is for corporations with up to 100 employees including startups and non-profit organizations (Universities, Research institute). Membership C is for individuals. The A and B memberships allow for the member organizations to use the conference rooms and temporary Top players of the life science field all over the world working rooms for hosting meetings, events and receptions. are joining LINK-J. You can benefit by joining this network and becoming a part of our community. 440+ Members Membership A Membership B Membership C (Corporations) (Corporations and NPOs) (Individuals)

· Individuals such as doctors · Corporations with up to 100 · Employees and providers of employees corporations and organizations Corporations with 100+ employees · Non-profit organizations · Employees and providers of (Universities, Research institute) non-profit organizations · College and graduate students Entrance fee: 100,000 yen Entrance fee: 30,000 yen Entrance fee: 2,000 yen Membership fee: 500,000 yen Membership fee: 120,000 yen Membership fee: 3,000-30,000 yen

Benefit

Events and Programs (members’ special prices)

Networking

Consulting by LINK-J Supporters

Use of the LINK-J Exclusive Communication Lounge (Complimentary)

Use of the Service Office (Separate contacts applyed)

Events and programs notification service on the LINK-J website and via e-mail

Publication on the homepage, brochure, etc.

Private use of the exclusive LINK-J communication lounge (Members Price)

Use of the conference room or temporary working room (Members Price)

5 6 Domestic and International Collaborations

We have agreed on partnering with 14 organizations including universities around the world. We collaborate through hosting programs and events, exchanging publications, materials and information, providing services to each other’s members, visiting, joint hosting and/or sponsorship of activities and collaborating on advertisements. COLLABORATIONS One Nucleus Institute for Advanced Biosciences, Oxford University Innovation MedCity Keio University University of California, Los Angeles Kanagawa Eurobiomed Osaka Kawasaki City BIOCOM Yokohama City

University of California, San Diego Kyoto Research Park

Foundation for Biomedical Research and Innovation at Kobe

LINK-J will continue to provide valuable information and increased chances for networking in collaboration with Date of MOU signed Name of organization renowned institutions, organizations and universities across the world. 14 Collaborations May 2016 University of California, San Diego (UCSD), USA

May 2016 BIOCOM, USA

June 2017 Eurobiomed, France

July 2017 Kyoto Research Park, Corp., Japan

December 2017 One Nucleus, UK

Foundation for Biomedical Research and Innovation at January 2018 Kobe, Japan

April 2018 Institute for Advanced Biosciences, Keio University, Japan

June 2018 MedCity, UK

August 2018 City of Kawasaki, Japan

June 2019 University of California, Los Angeles (UCLA), USA

August 2019 City of Yokohama, Japan

July 2020 Oxford University Innovation（OUI）,UK

September 2020 Osaka, Japan

September 2020 Kanagawa, Japan

7 8 Board members

Chairman of Chairman, Graduate School of Medicine, Keio University / Professor, Department of Physiology, Hideyuki Okano, M.D., Ph.D. the Board Graduate School of Medicine, Keio University Vice Chairman Yoshiki Sawa, M.D., Ph.D. Professor, Department of Cardiovascular Surgery, Osaka University Graduate School of Medicine of the Board Director Takashi Ueda Executive Managing Officer, Co., Ltd. Director Akihiko Soyama President and Chief Executive Officer of Life Science Innovation Network Japan Auditor Yutaro Kikuchi Director, Kikuchi Sogo Law Office ORGANIZATIONS Auditor Shigeru Sugimoto Managing Partner, Sakura & Co. Management Advisory Committee

Special Advisor Yoichiro Matsumoto, Dr. Eng. President, Tokyo University of Science Special Advisor Shinya Yamanaka, M.D., Director and Professor, Center for iPS Cell Research and Application (CiRA) Kyoto University; Nobel Ph.D. laureate in Physiology / Medicine Special Advisor Peter F. Cowhey, Ph.D. Dean, School of Global Policy & Strategy, University of California, San Diego Advisor Shinji Asonuma Executive Vice-President for Industry-Government-Academia Collaboration, Kyoto University Advisor Hironori Kasahara, Ph.D. Senior Executive Vice President for Research and IT Promotion, Waseda University Advisor Hidetoshi Kotera Executive Director, RIKEN Advisor Isao Teshirogi, Ph.D. President, The Federation of Pharmaceutical Manufacturers' Associations of JAPAN (FPMAJ) / President and CEO of Shionogi & Co., Ltd. Advisor George Nakayama President, Japan Pharmaceutical Manufacturers Association (JPMA) / Chairman and CEO, Co., Ltd. Advisor Ken-ichiro Hata, D.D.S., Ph.D. Chairman, Forum for Innovative Regenerative Medicine (FIRM) / President and CEO, Japan Tissue Our activities are supported by management advisory Engineering Co., Ltd. (J-TEC) committee members and supporters who possess Advisor Toshiaki Higashihara President & CEO, , Ltd. specialized expertise and experience. Advisor Kenichi Matsumoto Chairman, the Japan Federation of Medical Devices Associations / Chairman, Sakura Global Holding Co., Ltd + Advisor Masaaki Mizuno, M.D., Ph.D. Director and Clinical Professor, Center for Advanced Medicine and Clinical Research, Department of The management advisory committee is composed 35 Supporters Advanced Medicine, University Hospital of industry leaders who strongly support us with their Advisor Takuro Ueda Director, Office of Cooperative Research and Development, Tohoku University Advisor Toshiya Watanabe, Ph.D. Professor, Institute for Future Initiatives, University of Tokyo broad-based knowledge and experience. They also Advisor Masanobu Komoda President and CEO, Mitsui Fudosan Co., Ltd. offer strategic advice to the Board of Directors. LINK-J has recruited a number of supporters, people Supporters with knowledge spanning diverse fields and whose skill sets range from research and development to Masanori Akita MTI Ltd. Toru J. Seo, Ph.D. Pfizer Japan Inc. Tsuyoshi Ito Beyond Next Ventures Tohru Takashi, Ph.D. Japan Agency for Medical Research and Development management, law, and finance. Our supporters, who Taro Inaba REMIGES Ventures Shunichi Takahashi, Ph.D. Bayer Yakuhin, Ltd. include entrepreneurs and experts, participate in many Yo Iwami, M.D., Ph.D. MedPeer, Inc. Koichiro Tsujimaru, Ph.D. Tsujimaru International Patent Office of the events that we put together and offer one-on-one Atsushi Usami, Ph.D. The University of Tokyo Edge Capital Co., Ltd. Shingo Tsuda INDEE Japan Ltd. Takahiro Uchida, M.D. Japanese Organization for Medical advice to LINK-J special members. Takuma Nakatsuka POC Clinical Research Inc. Ph.D., MSc. Device Development, Inc. Hajime Oshita MedVenture Partners, Inc. Shogo Nishida Boston Consulting Group Jun Otomo, Ph.D. Hitachi, Ltd. Takato Noumi, Ph.D. FORESIGHT & LINX K.K. Hardy TS Kagimoto, Healios K.K. Nobuhiko Hibara, Ph.D. Waseda Business School M.D. Hiroaki Kato, M.D. Aillis Inc. Ryuji Hiramatsu, Ph.D. Foundation for Biomedical Research and Innovation at Kobe Hiroyuki Kanoh Forum for Innovative Regenerative Medicine Kinji Fuchikami Mitsui & Co. Global Investment, Inc. Tomy Kamada, Ph.D. TomyK Ltd. Ikkei Matsuda, Ph.D., MBA Science, Art & Research for Reconstruction (SARR) Masashi Matsunaga, Makio Kitazawa Boston Consulting Group Biospire Japan, Ltd. Ph.D. Hiroaki Kitano, Ph.D. Computer Science Laboratories Mika Mizunuma, Ph.D. Craif, Inc Takashi Kiyoizumi, M.D., Ph.D. University of California, San Diego Keita Mori SanBio Company Limited Masashi Kiyomine Kicker Ventures Daiki Moriyama Deloitte Tohmatsu Venture Support Co., Ltd. Yohei Sawayama Coral Capital Yuji Yamamoto, M.D., MBA MinaCare Co., Ltd. Aki Shimauchi INDEE Medical, Inc. Masayuki Yokota , Inc. Tsutomu Sugaya Nobelpharma Co., Ltd. Hayato Watanabe, CFA Locust Walk Japan, LLC Ulrike Schaede, Ph.D. University of California, San Diego (UCSD)

9 10 Conference Rooms

There are various sized rooms that can be used for meetings, lectures, seminars, happy hours, special events, etc. These spaces are also equipped with sound and audio-visual facilities necessary for presentations. (Some incur extra charges)

• Nihonbashi Life Science Hub FACILITIES • Nihonbashi Life Science Building • Nihonbashi Life Science Building2 • Lifescience Hub West

Communication Lounges

The LINK-J Communication Lounge is exclusively for members. There are books, complementary drinks and snacks for sale in the members-only area. The 10th floor lounge in Nihonbashi Life Science Building and foyer area of the Nihonbashi Life Science Hub is available for meets- and-greets, receptions, etc.

• Nihonbashi Life Science Hub We operate conference rooms and communication • Nihonbashi Life Science Building (1st and 10th floors) lounges for the exclusive use of LINK-J members located • Ueno Building in the middle of Nihonbashi, an easily accessible • Tosho Building center of business. We help you build a new network 10+ buildings • Lifescience Hub West and create your new business in a bright and open atmosphere. Temporary Working Rooms

On the 3rd floor of the Nihonbashi Life Science Building, there is a space that can be reserved for up to 7 days on a per-day basis.

Serviced Offices

We offer a wide-range of possibilities from secured individual booths to open desks and are pleased to accommodate your needs. You can also register this location as your office. This space is also furnished and does not require a deposit allowing you to keep your startup fees low. • 5th floor, Nihonbashi Life Science Building • Ueno Building • Tosho Building • Lifescience Hub West

Offices and Laboratory

We rent out small to large sized offices to adjust to the size of your business. The wet lab facilities necessary for practical application of research results and creation of innovation.

11 12 Location:

Exit 4 Life Science Innovation Network Japan (LINK-J) Exit 1 Tokyo Metro Line Kodenmacho Station Address:2F Nihonbashi IT building, 3-3-9 Nihonbashi muromachi, Chuo-ku, Tokyo 103-0022Exit, Japan 3 Phone (within Japan): 03-3241-4911; Phone (outside Japan): +81-3-3241-4911 Fax (within Japan): 03-3241-3757; Fax (outside Japan): +81-3-3241-3757 Seijo IshiiIshiiSeijo Sobu Line

Honcho ９ Exit 8 4 ACCESS JR Sobu Rapid Line Exit 6 5 Shin-Nihonbashi Station Exit 5 3 Exit 4

Exit 2 -dori Street Suginomori Shrine LINK-J Daiichi Sankyo Headquarters NOF Horidomecho Chuo-dori Street Nihonbashi Honcho Building Underpass 6 Nihonbashi Muromachi Mitsui Tower Exit A10 １

Exit A9 Doutor ■■Doutor Doutor ■■Doutor YUITOYUITO Lawson ■■Lawson Nihonbashi Astellas Exit A8 Fukutoku Shrine ■ Mitsui Building Tokyo Metro Hibiya Line Starbucks Tokyo Metro Line Honcho 2-chome Ningyocho Station Mitsukoshi-mae Station Exit A6 COREDO Muromachi 2 Horidome Children’s Park Nihonbashi COREDO 7 Exit A4 Mitsui Tower Muromachi 1 Exit A7 Bank of Japan Exit A5 Mitsui Main building 2 COREDO Muromachi 3 Nihonbashi Life Science Facilites are located in a Exit A5 Toei Subway Line Exit A4 8 Ningyocho Station convenient location that is about a 10-minute walk from Mitsukoshi Main building Exit A3 Seven-Eleven ■ and is accessible with many subway lines. Nihonbashi Honcho 2-3-11, Chuo-ku, Tokyo 103–0023 ①Tokyo Nihonbashi Metro Hanzomon Life LineScience BuildingExit A1 (LSB) Mitsukoshi-mae Station Mitsukoshi Annex building ■ Seven-Eleven Nihonbashi is also a place with a high concentration of Nihonbashi Muromachi 1-5-5, Chuo-ku, Tokyo 103–0022 ② Nihonbashi Life ScienceExit HubA2 (HUB) commercial facilities with many historic buildings while ③ Nihonbashi Life ScienceExit Building B4 Tokyo 2 (LSB2) Metro Hanzomon Line Nihonbashi Honcho 3-11-5,Toei Subway Chuo-ku, Asakusa Tokyo Line103–0023 being a robust hub of business activities. ④ Tosho Building Nihonbashi Honcho 3-8-3, Chuo-ku, Tokyo 103–0023 We invite you to creatively innovate with us! ⑤ MFPR Nihonbashi Honcho Building Nihonbashi Honcho 3-7-2, Chuo-ku, Tokyo 103–0023 ⑥ Ueno Building Nihonbashi Horidomecho 1-9-10, Chuo-ku, Tokyo 103–0012 ⑦ LAUNCH Nihonbashi Ningyocho Nihonbashi Ningyocho 3-7-6, Chuo-ku, Tokyo 103–0013 ⑧ Fukushima Building Nihonbashi Muromachi 1-5-3, Chuo-ku, Tokyo 103–0022 ⑨ Nihonbashi Honcho 3-Chome Building Nihonbashi Honcho 3-8-5, Chuo-ku, Tokyo 103–0023

① ② ③

④ ⑤ ⑥

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⑦ ⑧ ⑨

⑩

⑩ Lifescience Hub West

Bingo-machi 4-1-3,, Chuo-ku, Osaka-city, Osaka, 541-0051

13 14