February 26, 2013 u vol. 110 u no. 9 u 3199–3652

Cover image: Pictured is an illustration showing membranous vesicles transported by motor proteins along microtubules, overlaid on a super-resolution image of the microtubule net-  work captured by using stochastic optical reconstruction microscopy (STORM). Stefan Bálint et al. studied the effects of 3D microtubule architecture on cargo transport at microtubule– microtubule intersections by correlating single particle trajectories of lysosomes with super- resolution images of the microtubule network. The findings suggest that motor activity is highly regulated to maneuver through cytoskeletal obstructions, and provide insights into the impact of cytoskeletal geometry on cargo transport. See the article by Bálint et al. on pages 3375–3380. Illustration courtesy of Álex Salmerón (Digivision, Reus, Spain). Background  image courtesy of Stefan Bálint, Ione Verdeny Vilanova, and Melike Lakadamyali. From the Cover

3375 Intracellular transport dynamics 3339 Acetylation and the circadian clock 3549 Brain metabolism and animal size 3615 Insect antenna grooming 3621 Bilin signaling in green algae

Contents SCIENCE AND CULTURE

3205 Weaving weather Raven Hanna THIS WEEK IN PNAS

3199 In This Issue RETROSPECTIVE

LETTERS (ONLINE ONLY) 3206 The kingdoms of Carl Woese Larry Gold

E786 Need for conclusive evidence that positive and negative reciprocity are unrelated Boris Egloff, David Richter, and Stefan C. Schmukle INNER WORKINGS E787 Reply to Egloff et al.: On the relationship between positive and negative reciprocity 3208 Filming chimpanzee gestures Toshio Yamagishi Sandeep Ravindran

OPINION CORE CONCEPTS

3201 Mortgaging the future of chinese paleontology Xiaoming Wang 3209 Epigenetics Sarah C. P. Williams

NEWS FEATURE COMMENTARIES 3202 Foraging flights Stephen Ornes 3210 Protein acetylation links the circadian clock to mitochondrial function Guillaume Rey and Akhilesh B. Reddy Free online through the PNAS open access option. See companion article on page 3339

PNAS u February 26, 2013 u vol. 110 u no. 9 u iii–viii Downloaded by guest on September 28, 2021 3212 Learning from cancer how to defeat bacteria MEDICAL SCIENCES José N. Onuchic, Patricia A. Jennings, 3225 Selective capacity of metreleptin administration to + and Eshel Ben-Jacob reconstitute CD4 T-cell number in females with See companion article on page 3477 acquired hypoleptinemia 3214 Glucocerebrosidase in the pathogenesis and treatment Giuseppe Matarese, Claudia La Rocca, Hyun-Seuk of Parkinson disease Moon, Joo Young Huh, Mary T. Brinkoetter, Sharon Anthony H. V. Schapira and Matthew E. Gegg Chou, Francesco Perna, Dario Greco, Holly P. Kilim, See companion article on page 3537 Chuanyun Gao, Kalliope Arampatzi, Zhaoxi Wang, and Christos S. Mantzoros 3216 Allometry of brain metabolism See full research article on page E818 of www.pnas.org Robert S. Balaban See companion article on page 3549 MICROBIOLOGY 3218 Surprising roles for bilins in a green alga 3227 Captured retroviral envelope syncytin gene associated Jean-David Rochaix with the unique placental structure of higher ruminants See companion article on page 3621 Guillaume Cornelis, Odile Heidmann, Séverine A. Degrelle, Cécile Vernochet, Christian Lavialle, Claire Letzelter, Sibylle Bernard-Stoecklin, Alexandre Hassanin, Baptiste Mulot, Michel Guillomot, Isabelle Hue, Thierry Heidmann, PNAS PLUS and Anne Dupressoir See full research article on page E828 of www.pnas.org 3220 SIGNIFICANCE STATEMENTS

BIOLOGICAL SCIENCES PERSPECTIVE GENETICS E808 Male-specific lethal complex in Drosophila counteracts 3229 Animals in a bacterial world, a new imperative for the histone acetylation and does not mediate dosage life sciences fi compensation Margaret McFall-Ngai, Michael G. Had eld, Thomas C. G.  Lin Sun, Harvey R. Fernandez, Ryan C. Donohue, Bosch, Hannah V. Carey, Tomislav Domazet-Loso, Angela E. Jilong Li, Jianlin Cheng, and James A. Birchler Douglas, Nicole Dubilier, Gerard Eberl, Tadashi Fukami, Scott F. Gilbert, Ute Hentschel, Nicole King, Staffan Kjelleberg, Andrew H. Knoll, Natacha Kremer, Sarkis K. MICROBIOLOGY Mazmanian, Jessica L. Metcalf, Kenneth Nealson, Naomi E. E838 Deubiquitinase function of arterivirus papain-like Pierce, John F. Rawls, Ann Reid, Edward G. Ruby, protease 2 suppresses the innate immune response Mary Rumpho, Jon G. Sanders, Diethard Tautz, in infected host cells and Jennifer J. Wernegreen Puck B. van Kasteren, Ben A. Bailey-Elkin, Terrence W. James, Dennis K. Ninaber, Corrine Beugeling, Mazdak Khajehpour, Eric J. Snijder, Brian L. Mark, and Marjolein Kikkert PHYSICAL SCIENCES

SYSTEMS BIOLOGY APPLIED MATHEMATICS E848 Coupling mutagenesis and parallel deep sequencing 3237 Generation of dispersion in nondispersive nonlinear to probe essential residues in a genome or gene waves in thermal equilibrium William P. Robins, Shah M. Faruque, and John J. Mekalanos Wonjung Lee, Gregor Kovacic, and David Cai

AUTHOR SUMMARIES APPLIED PHYSICAL SCIENCES 3242 Morphology transition in lipid vesicles due to in-plane BIOLOGICAL SCIENCES order and topological defects Linda S. Hirst, Adam Ossowski, Matthew Fraser, Jun Geng, BIOCHEMISTRY Jonathan V. Selinger, and Robin L. B. Selinger 3221 Human mitochondrial holocytochrome c synthase’s 3248 Mechanical model of blebbing in nuclear heme binding, maturation determinants, and complex lamin meshworks formation with cytochrome c Chloe M. Funkhouser, Rastko Sknepnek, Takeshi Brian San Francisco, Eric C. Bretsnyder, and Robert G. Kranz Shimi, Anne E. Goldman, Robert D. Goldman, See full research article on page E788 of www.pnas.org and Monica Olvera de la Cruz

DEVELOPMENTAL BIOLOGY 3254 How superhydrophobicity breaks down Periklis Papadopoulos, Lena Mammen, Xu Deng, 3223 BMP4-mediated brown fat-like changes in white adipose Doris Vollmer, and Hans-Jürgen Butt tissue alter glucose and energy homeostasis Shu-Wen Qian, Yan Tang, Xi Li, Yuan Liu, You-You Zhang, Hai-Yan Huang, Rui-Dan Xue, Hao-Yong Yu, Liang Guo, EARTH, ATMOSPHERIC, AND PLANETARY SCIENCES Hui-Di Gao, Yan Liu, Xia Sun, Yi-Ming Li, Wei-Ping Jia, 3259 Vegetation engineers marsh morphology through and Qi-Qun Tang multiple competing stable states See full research article on page E798 of www.pnas.org Marco Marani, Cristina Da Lio, and Andrea D’Alpaos

iv u www.pnas.org Downloaded by guest on September 28, 2021 3264 Probabilistic framework for assessing the ice sheet BIOLOGICAL SCIENCES contribution to sea level change Christopher M. Little, Nathan M. Urban, and Michael Oppenheimer ANTHROPOLOGY

3423 Fossil evidence for a hyperdiverse sclerophyll flora 3298 Strontium isotopes document greater human mobility – at the start of the Balkan Neolithic under a non Mediterranean-type climate   J. M. Kale Sniderman, Gregory J. Jordan, Dusan Boric and T. Douglas Price and Richard M. Cowling

APPLIED BIOLOGICAL SCIENCES ENGINEERING 3304 Defining a protective epitope on factor H binding 3270 Particle shape enhances specificity of protein, a key meningococcal virulence factor and antibody-displaying nanoparticles vaccine antigen Sutapa Barua, Jin-Wook Yoo, Poornima Kolhar, Aditya Enrico Malito, Agnese Faleri, Paola Lo Surdo, Daniele Veggi, Wakankar, Yatin R. Gokarn, and Samir Mitragotri Giulietta Maruggi, Eva Grassi, Elena Cartocci, Isabella Bertoldi, Alessia Genovese, Laura Santini, Giacomo 3276 Geometry of Miura-folded metamaterials Romagnoli, Erica Borgogni, Sébastien Brier, Carla Lo Passo, Mark Schenk and Simon D. Guest Maria Domina, Flora Castellino, Franco Felici, Stijn van der Veen, Steven Johnson, Susan M. Lea, Christoph M. Tang, Mariagrazia Pizza, Silvana Savino, Nathalie Norais, Rino PHYSICS Rappuoli, Matthew J. Bottomley, and Vega Masignani 3282 Interaction phenomena in graphene seen through quantum capacitance 3310 Ultralocalized thermal reactions in G. L. Yu, R. Jalil, Branson Belle, Alexander S. Mayorov, Peter subnanoliter droplets-in-air Blake, Frederick Schedin, Sergey V. Morozov, Leonid A. Eric Salm, Carlos Duarte Guevara, Piyush Dak, Ponomarenko, F. Chiappini, S. Wiedmann, Uli Zeitler, Brian Ross Dorvel, Bobby Reddy, Jr., Muhammad Mikhail I. Katsnelson, A. K. Geim, Kostya S. Novoselov, Ashraf Alam, and Rashid Bashir and Daniel C. Elias 3316 Vaccinia virus-mediated melanin production allows MR and optoacoustic deep tissue imaging and laser-induced 3287 Incommensurate antiferromagnetism in a pure spin thermotherapy of cancer system via cooperative organization of local and Jochen Stritzker, Lorenz Kirscher, Miriam Scadeng, itinerant moments Nikolaos C. Deliolanis, Stefan Morscher, Panagiotis Yejun Feng, Jiyang Wang, D. M. Silevitch, B. Mihaila, Symvoulidis, Karin Schaefer, Qian Zhang, Lisa Buckel, J. W. Kim, J.-Q. Yan, R. K. Schulze, Nayoon Woo, Michael Hess, Ulrike Donat, William G. Bradley, Vasilis A. Palmer, Y. Ren, Jasper van Wezel, P. B. Littlewood, Ntziachristos, and Aladar A. Szalay and T. F. Rosenbaum

3293 Anomalous superfluid density in quantum critical superconductors BIOCHEMISTRY Kenichiro Hashimoto, Yuta Mizukami, Ryo Katsumata, 3321 Quantitative analysis of the time course of Aβ Hiroaki Shishido, Minoru Yamashita, Hiroaki Ikeda, Yuji oligomerization and subsequent growth steps Matsuda, John A. Schlueter, Jonathan D. Fletcher, Antony using tetramethylrhodamine-labeled Aβ Carrington, Daniel Gnida, Dariusz Kaczorowski, Kanchan Garai and Carl Frieden and Takasada Shibauchi 3327 Bipartite determinants mediate an evolutionarily conserved interaction between Cdc48 and the 20S peptidase Dominik Barthelme and Robert T. Sauer SOCIAL SCIENCES 3333 Pharmacological modulation of circadian rhythms by synthetic activators of the deacetylase SIRT1 ANTHROPOLOGY Marina M. Bellet, Yasukazu Nakahata, Mohamed Boudjelal, 3298 Strontium isotopes document greater human mobility Emma Watts, Danuta E. Mossakowska, Kenneth A. Edwards, at the start of the Balkan Neolithic Marlene Cervantes, Giuseppe Astarita, Christine Loh,   Dusan Boric and T. Douglas Price James L. Ellis, George P. Vlasuk, and Paolo Sassone-Corsi

3339 Circadian acetylome reveals regulation of mitochondrial SUSTAINABILITY SCIENCE metabolic pathways 3264 Probabilistic framework for assessing the ice sheet Selma Masri, Vishal R. Patel, Kristin L. Eckel-Mahan, Shahaf contribution to sea level change Peleg, Ignasi Forne, Andreas G. Ladurner, Pierre Baldi, Christopher M. Little, Nathan M. Urban, Axel Imhof, and Paolo Sassone-Corsi and Michael Oppenheimer See Commentary on page 3210 3639 Integrating indigenous livelihood and lifestyle 3345 Structure of an actin-related subcomplex of the SWI/SNF objectives in managing a natural resource chromatin remodeler Éva Elizabeth Plagányi, Ingrid van Putten, Trevor Hutton, Heidi L. Schubert, Jacqueline Wittmeyer, Margaret M. Roy A. Deng, Darren Dennis, Sean Pascoe, Tim Skewes, Kasten, Kaede Hinata, David C. Rawling, Annie Héroux, and Robert A. Campbell Bradley R. Cairns, and Christopher P. Hill

PNAS u February 26, 2013 u vol. 110 u no. 9 u v Downloaded by guest on September 28, 2021 3351 Positive and negative feedback loops in the p53 and 3417 Chicken hemogen homolog is involved in the mRNA 3′ processing pathways chicken-specific sex-determining mechanism Emral Devany, Xiaokan Zhang, Ji Yeon Park, Bin Tian, Tomohiro Nakata, Manabu Ishiguro, Nana Aduma, and Frida Esther Kleiman Hiroe Izumi, and Asato Kuroiwa 3357 Rules that govern UPF1 binding to mRNA 3′ UTRs Tatsuaki Kurosaki and Lynne E. Maquat ECOLOGY 3423 Fossil evidence for a hyperdiverse sclerophyll flora BIOPHYSICS AND COMPUTATIONAL BIOLOGY under a non–Mediterranean-type climate J. M. Kale Sniderman, Gregory J. Jordan, 3242 Morphology transition in lipid vesicles due to in-plane and Richard M. Cowling order and topological defects

Linda S. Hirst, Adam Ossowski, Matthew Fraser, Jun Geng, 3429 Surface exposure to sunlight stimulates CO2 release Jonathan V. Selinger, and Robin L. B. Selinger from permafrost soil carbon in the Arctic Rose M. Cory, Byron C. Crump, Jason A. Dobkowski, 3363 Effect of charge, hydrophobicity, and sequence of and George W. Kling nucleoporins on the translocation of model particles through the nuclear pore complex Mario Tagliazucchi, Orit Peleg, Martin Kröger, ENVIRONMENTAL SCIENCES Yitzhak Rabin, and Igal Szleifer 3259 Vegetation engineers marsh morphology through multiple competing stable states 3369 Voltage sensor ring in a native structure of Marco Marani, Cristina Da Lio, and Andrea D’Alpaos a membrane-embedded potassium channel Liang Shi, Hongjin Zheng, Hui Zheng, Brian A. Borkowski, 3435 Diverse and abundant antibiotic resistance genes Dan Shi, Tamir Gonen, and Qiu-Xing Jiang in Chinese swine farms Yong-Guan Zhu, Timothy A. Johnson, Jian-Qiang Su, 3375 Correlative live-cell and superresolution microscopy Min Qiao, Guang-Xia Guo, Robert D. Stedtfeld, reveals cargo transport dynamics at Syed A. Hashsham, and James M. Tiedje microtubule intersections  Stefan Bálint, Ione Verdeny Vilanova, Ángel Sandoval Álvarez, and Melike Lakadamyali EVOLUTION 3441 Diversification of rhacophorid frogs provides evidence 3381 In vivo optical trapping indicates kinesin’s stall force is reduced by dynein during intracellular transport for accelerated faunal exchange between India and Eurasia during the Oligocene Benjamin H. Blehm, Trina A. Schroer, Kathleen M. Trybus, Jia-Tang Li, Yang Li, Sebastian Klaus, Ding-Qi Rao, Yann R. Chemla, and Paul R. Selvin David M. Hillis, and Ya-Ping Zhang

CELL BIOLOGY GENETICS 3387 Long noncoding RNAs regulate adipogenesis 3447 Persistent whole-chromosome aneuploidy is generally Lei Sun, Loyal A. Goff, Cole Trapnell, Ryan Alexander, associated with nascent allohexaploid wheat Kinyui Alice Lo, Ezgi Hacisuleyman, Martin Sauvageau, Huakun Zhang, Yao Bian, Xiaowan Gou, Bo Zhu, Chunming Barbara Tazon-Vega, David R. Kelley, David G. Hendrickson, Xu, Bao Qi, Ning Li, Sachin Rustgi, Hao Zhou, Fangpu Han, Bingbing Yuan, Manolis Kellis, Harvey F. Lodish, and John L. Rinn Jiming Jiang, Diter von Wettstein, and Bao Liu 3393 Deglycosylation-dependent fluorescent proteins 3453 Severity of cardiomyopathy associated with adenine fi provide unique tools for the study of nucleotide translocator-1 de ciency correlates with mtDNA haplogroup ER-associated degradation Kevin A. Strauss, Lauren DuBiner, Mariella Simon, Michael Jeff E. Grotzke, Qiao Lu, and Peter Cresswell Zaragoza, Partho P. Sengupta, Peng Li, Navneet Narula, 3399 Improving spinning disk confocal microscopy by Sandra Dreike, Julia Platt, Vincent Procaccio, Xilma R. preventing pinhole cross-talk for intravital imaging Ortiz-González, Erik G. Puffenberger, Richard I. Kelley, Togo Shimozawa, Kazuo Yamagata, Takefumi Kondo, Shigeo D. Holmes Morton, Jagat Narula, and Douglas C. Wallace Hayashi, Atsunori Shitamukai, Daijiro Konno, Fumio Matsuzaki, Jun Takayama, Shuichi Onami, Hiroshi IMMUNOLOGY Nakayama, Yasuhito Kosugi, Tomonobu M. Watanabe, Katsumasa Fujita, and Yuko Mimori-Kiyosue 3459 Previously undescribed grass pollen antigens are the major inducers of T helper 2 cytokine-producing T cells in allergic individuals DEVELOPMENTAL BIOLOGY Véronique Schulten, Jason A. Greenbaum, Michael Hauser, 3405 Prospective isolation of human embryonic stem Denise M. McKinney, John Sidney, Ravi Kolla, Cecilia S. cell-derived cardiovascular progenitors that integrate Lindestam Arlehamn, Carla Oseroff, Rapheul Alam, into human fetal heart tissue David H. Broide, Fatima Ferreira-Briza, Howard M. Grey, Reza Ardehali, Shah R. Ali, Matthew A. Inlay, Oscar J. Alessandro Sette, and Bjoern Peters Abilez, Michael Q. Chen, Timothy A. Blauwkamp, Masayuki 3465 Tapasin-related protein TAPBPR is an additional Yazawa, Yongquan Gong, Roeland Nusse, Micha Drukker, component of the MHC class I presentation pathway and Irving L. Weissman Louise H. Boyle, Clemens Hermann, Jessica M. Boname, 3411 Mitosis–meiosis and sperm–oocyte fate decisions Keith M. Porter, Peysh A. Patel, Marian L. Burr, Lidia M. are separable regulatory events Duncan, Michael E. Harbour, David A. Rhodes, Karsten Clinton T. Morgan, Daniel Noble, and Judith Kimble Skjødt, Paul J. Lehner, and John Trowsdale

vi u www.pnas.org Downloaded by guest on September 28, 2021 3471 Antidiabetogenic MHC class II promotes the 3513 Alternative erythropoietin-mediated signaling prevents differentiation of MHC-promiscuous autoreactive secondary microvascular thrombosis and inflammation T cells into FOXP3+ regulatory T cells within cutaneous burns Sue Tsai, Pau Serra, Xavier Clemente-Casares, Jun Stefan Bohr, Suraj J. Patel, Keyue Shen, Antonia G. Vitalo, Yamanouchi, Shari Thiessen, Robyn M. Slattery, Michael Brines, Anthony Cerami, Francois Berthiaume, John F. Elliott, and Pere Santamaria and Martin L. Yarmush

MEDICAL SCIENCES MICROBIOLOGY 3477 Mechanism of action and initial evaluation of 3519 Human genome-wide RNAi screen reveals a a membrane active all-D-enantiomer role for nuclear pore proteins in poxvirus antimicrobial peptidomimetic morphogenesis Danielle M. McGrath, E. Magda Barbu, Wouter H. P. Gilad Sivan, Scott E. Martin, Timothy G. Myers, Driessen, Todd M. Lasco, Jeffrey J. Tarrand, Pablo C. Eugen Buehler, Krysia H. Szymczyk, Pinar Ormanoglu, Okhuysen, Dimitrios P. Kontoyiannis, Richard L. Sidman, and Bernard Moss Renata Pasqualini, and Wadih Arap 3525 Trio engagement via plasma membrane phospholipids See Commentary on page 3212 and the myristoyl moiety governs HIV-1 matrix binding 3483 Identification of CDCP1 as a hypoxia-inducible factor 2α to bilayers (HIF-2α) target gene that is associated with survival in Jiri Vlach and Jamil S. Saad clear cell renal cell carcinoma patients 3531 Small molecule inhibitor of lipoteichoic acid synthesis Brooke M. Emerling, Cyril H. Benes, George Poulogiannis, is an antibiotic for Gram-positive bacteria Eric L. Bell, Kevin Courtney, Hui Liu, Rayman Choo-Wing, Stefan G. Richter, Derek Elli, Hwan Keun Kim, Antoni P. A. Gary Bellinger, Kazumi S. Tsukazawa, Victoria Brown, Sabina Hendrickx, Joseph A. Sorg, Olaf Schneewind, Signoretti, Stephen P. Soltoff, and Lewis C. Cantley and Dominique Missiakas 3489 Recessive loss of function of the neuronal ubiquitin hydrolase UCHL1 leads to early-onset NEUROSCIENCE progressive neurodegeneration Kaya Bilguvar, Navneet K. Tyagi, Cigdem Ozkara, Beyhan 3537 Augmenting CNS glucocerebrosidase activity as Tuysuz, Mehmet Bakircioglu, Murim Choi, Sakir Delil, a therapeutic strategy for parkinsonism and other Ahmet O. Caglayan, Jacob F. Baranoski, Ozdem Erturk, Gaucher-related synucleinopathies Cengiz Yalcinkaya, Murat Karacorlu, Alp Dincer, Michele H. S. Pablo Sardi, Jennifer Clarke, Catherine Viel, Monyrath Johnson, Shrikant Mane, Sreeganga S. Chandra, Angeliki Chan, Thomas J. Tamsett, Christopher M. Treleaven, Louvi, Titus J. Boggon, Richard P. Lifton, Arthur L. Horwich, Jie Bu, Lindsay Sweet, Marco A. Passini, James C. Dodge, and Murat Gunel W. Haung Yu, Richard L. Sidman, Seng H. Cheng, and Lamya S. Shihabuddin 3495 8-CPT-cAMP/all-trans retinoic acid targets t(11;17) acute See Commentary on page 3214 promyelocytic leukemia through enhanced cell β differentiation and PLZF/RARα degradation 3543 Targeting estrogen receptor in microglia and Bo Jiao, Zhi-Hong Ren, Ping Liu, Li-Juan Chen, T cells to treat experimental autoimmune Jing-Yi Shi, Ying Dong, Julien Ablain, Lin Shi, Li Gao, encephalomyelitis Jun-Pei Hu, Rui-Bao Ren, Hugues de Thé, Zhu Chen, Wan-fu Wu, Xin-jie Tan, Yu-bing Dai, Venkatesh Krishnan, and Sai-Juan Chen Margaret Warner, and Jan-Åke Gustafsson 3501 Anti-KIT monoclonal antibody inhibits imatinib-resistant 3549 Cortical energy demands of signaling and nonsignaling gastrointestinal stromal tumor growth components in brain are conserved across mammalian Badreddin Edris, Stephen B. Willingham, Kipp Weiskopf, species and activity levels Anne K. Volkmer, Jens-Peter Volkmer, Thomas Mühlenberg, Fahmeed Hyder, Douglas L. Rothman, Kelli D. Montgomery, Humberto Contreras-Trujillo, and Maxwell R. Bennett Agnieszka Czechowicz, Jonathan A. Fletcher, Robert B. See Commentary on page 3216 West, Irving L. Weissman, and Matt van de Rijn 3555 Expression profiling of mouse subplate reveals 3507 Genomic responses in mouse models poorly mimic a dynamic gene network and disease association human inflammatory diseases with autism and schizophrenia Junhee Seok, H. Shaw Warren, Alex G. Cuenca, Michael N. Anna Hoerder-Suabedissen, Franziska M. Oeschger, Mindrinos, Henry V. Baker, Weihong Xu, Daniel R. Richards, Michelle L. Krishnan, T. Grant Belgard, Wei Zhi Wang, Grace P. McDonald-Smith, Hong Gao, Laura Hennessy, Sheena Lee, Caleb Webber, Enrico Petretto, A. David Celeste C. Finnerty, Cecilia M. López, Shari Honari, Edwards, and Zoltán Molnár Ernest E. Moore, Joseph P. Minei, Joseph Cuschieri, Paul E. 3561 Neto2 is a KCC2 interacting protein required for neuronal − Bankey, Jeffrey L. Johnson, Jason Sperry, Avery B. Nathens, Cl regulation in hippocampal neurons Timothy R. Billiar, Michael A. West, Marc G. Jeschke, Evgueni A. Ivakine, Brooke A. Acton, Vivek Mahadevan, Jake Matthew B. Klein, Richard L. Gamelli, Nicole S. Gibran, Ormond, Man Tang, Jessica C. Pressey, Michelle Y. Huang, Bernard H. Brownstein, Carol Miller-Graziano, Steve E. David Ng, Eric Delpire, Michael W. Salter, Melanie A. Calvano, Philip H. Mason, J. Perren Cobb, Laurence G. Woodin, and Roderick R. McInnes Rahme, Stephen F. Lowry, Ronald V. Maier, Lyle L. Moldawer, David N. Herndon, Ronald W. Davis, Wenzhong 3567 Spatially clustered neuronal assemblies comprise the Xiao, Ronald G. Tompkins and the Inflammation and microstructure of synchrony in chronically Host Response to Injury, Large Scale Collaborative epileptic networks Research Program Sarah Feldt Muldoon, Ivan Soltesz, and Rosa Cossart

PNAS u February 26, 2013 u vol. 110 u no. 9 u vii Downloaded by guest on September 28, 2021 3573 Cholinergic signaling in the hippocampus regulates SUSTAINABILITY SCIENCE social stress resilience and anxiety- and 3639 Integrating indigenous livelihood and lifestyle depression-like behavior objectives in managing a natural resource Yann S. Mineur, Adetokunbo Obayemi, Mattis B. Éva Elizabeth Plagányi, Ingrid van Putten, Trevor Hutton, Wigestrand, Gianna M. Fote, Cali A. Calarco, Roy A. Deng, Darren Dennis, Sean Pascoe, Tim Skewes, Alice M. Li, and Marina R. Picciotto and Robert A. Campbell 3579 Dissociable dopaminergic control of saccadic target selection and its implications for reward modulation SYSTEMS BIOLOGY Alireza Soltani, Behrad Noudoost, and Tirin Moore 3645 Systematic measurement of transcription factor-DNA 3585 Neuronal long-range temporal correlations and interactions by targeted mass spectrometry identifies avalanche dynamics are correlated with behavioral candidate gene regulatory proteins scaling laws Hamid Mirzaei, Theo A. Knijnenburg, Bong Kim, Max J. Matias Palva, Alexander Zhigalov, Jonni Hirvonen, Onerva Robinson, Paola Picotti, Gregory W. Carter, Song Li, David J. Korhonen, Klaus Linkenkaer-Hansen, and Satu Palva Dilworth, Jimmy K. Eng, John D. Aitchison, Ilya Shmulevich, 3591 Inhibition of the prostaglandin receptor EP2 following Timothy Galitski, Ruedi Aebersold, and Jeffrey Ranish status epilepticus reduces delayed mortality and brain inflammation Jianxiong Jiang, Yi Quan, Thota Ganesh, Wendy A. Pouliot, F. Edward Dudek, and Raymond Dingledine CORRECTIONS 3597 Posttraining optogenetic manipulations of basolateral amygdala activity modulate consolidation of inhibitory APPLIED PHYSICAL SCIENCES, BIOPHYSICS AND avoidance memory in rats COMPUTATIONAL BIOLOGY Mary L. Huff, Rachel L. Miller, Karl Deisseroth, David E. 3651 Cancer radiotherapy based on femtosecond IR Moorman, and Ryan T. LaLumiere laser-beam filamentation yielding ultra-high dose rates and zero entrance dose PHARMACOLOGY Ridthee Meesat, Hakim Belmouaddine, Jean-François Allard, Catherine Tanguay-Renaud, Rosalie Lemay, 3603 Peripheral inflammatory hyperalgesia depends on the Tiberius Brastaviceanu, Luc Tremblay, Benoit Paquette, COX increase in the dorsal root ganglion J. Richard Wagner, Jean-Paul Jay-Gerin, Martin Lepage, Dionéia Araldi, Luiz Fernando Ferrari, Celina Monteiro Michael A. Huels, and Daniel Houde Lotufo, André Schwambach Vieira, Maria Carolina Pedro Athié, Jozi Godoy Figueiredo, Djane Braz Duarte, Claudia Herrera Tambeli, Sérgio Henrique Ferreira, APPLIED BIOLOGICAL SCIENCES and Carlos Amilcar Parada 3651 pHLIP peptide targets nanogold particles to tumors 3609 Phospholipase Ce links G protein-coupled receptor Lan Yao, Jennifer Danniels, Anna Moshnikova, activation to inflammatory astrocytic responses Sergey Kuznetsov, Aftab Ahmed, Donald M. Stephanie S. Dusaban, Nicole H. Purcell, Edward Engelman, Yana K. Reshetnyak, Rockenstein, Eliezer Masliah, Min Kyung Cho, and Oleg A. Andreev Alan V. Smrcka, and Joan Heller Brown

PHYSIOLOGY ECOLOGY 3615 Insects groom their antennae to enhance 3651 A common rule for decision making in animal olfactory acuity collectives across species Katalin Böröczky, Ayako Wada-Katsumata, Dale Batchelor, Sara Arganda, Alfonso Pérez-Escudero, Marianna Zhukovskaya, and Coby Schal and Gonzalo G. de Polavieja

PLANT BIOLOGY PHARMACOLOGY Chlamydomonas 3621 Retrograde bilin signaling enables 3651 Local injection of dsRNA targeting calcitonin greening and phototrophic survival receptor-like receptor (CLR) ameliorates Clostridium Deqiang Duanmu, David Casero, Rachel M. Dent, Sean difficile toxin A-induced ileitis Gallaher, Wenqiang Yang, Nathan C. Rockwell, Shelley S. Aditi Bhargava, Matthew S. Clifton, Pallavi Mhsake, Martin, Matteo Pellegrini, Krishna K. Niyogi, Sabeeha S. Min Liao, Charalabos Pothoulakis, Susan E. Leeman, Merchant, Arthur R. Grossman, and J. Clark Lagarias and Eileen F. Grady See Commentary on page 3218 3627 Asymmetric gibberellin signaling regulates vacuolar ix Subscription Form trafficking of PIN auxin transporters during root gravitropism Christian Löfke, Marta Zwiewka, Ingo Heilmann, Marc C. E. Supplement 1 Van Montagu, Thomas Teichmann, and Jirí Friml

3633 Evidence for participation of the methionine sulfoxide ARTHUR M. SACKLER COLLOQUIUM OF THE NATIONAL reductase repair system in plant seed longevity ACADEMY OF SCIENCES Emilie Châtelain, Pascale Satour, Edith Laugier, Benoit Ly Vu, Nicole Payet, Pascal Rey, and Françoise Montrichard 3653–3700 Fostering Advances in Interdisciplinary Climate Science

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