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Course Outline: MIMM214 1

Department of and McGill University

MIMM214 - INTRODUCTORY IMMUNOLOGY: ELEMENTS OF COURSE OUTLINE

1. GENERAL INFORMATION

Number of the course: MIMM214

Title of course: Introductory Immunology: Elements of Immunity

Description: The curriculum in Immunology is structured as a ribbon of courses extending from U1 to U3. In each of these years, there is a corresponding Immunology course that provides an introduction to the discipline (MIMM214), a mechanistic approach to Immunology (MIMM314) and an advanced exposure to current topics in Immunology (MIMM414).

MIMM214 is an introductory course providing an entry-level exposure to Immunology to a broad range of students: from those in a general science program to those going into Microbiology and Immunology as field of specialization.

As an introductory course, it emphasizes the description of molecular and cellular elements of the , and their basic . Emphasis is also placed in the biological context in which these elements operate to provide immunity and how the impairments of their function may result in .

The course will provide the required basis to tackle subsequent more advanced courses in Immunology.

Number of credits: 3 credits

Name & title of the Instructor: J. (Quim) Madrenas Professor and Chair, Department of Microbiology & Immunology Office: Duff Medical Building, Room 511 Phone: (514) 398-3914 E-mail: [email protected] http://www.mcgill.ca/microimm/members/professors/madrenas Office hours: Tuesdays from 03:00PM to 05:00PM. Contact Ms. Beatrice Doroga at (514) 398-7492 to make an appointment

Day, place and time of classes: M-W-F 12:35 to 13:25 (from Jan 5/2015 to April 10/2015) Adams Auditorium.

Prerequisite: BIOL200

Course Outline: MIMM214 2

Co-requisite: BIOL201 or ANAT212/BIOC212

Notes: Required course for U1 Microbiology & Immunology students Required course for Major (Stream A) students

2. COURSE CONTENT AND CALENDAR

Overview of the course. A brief history of Immunology 1 hour Jan 5/15

Learning the jargon: Immunity, , , Primary 1 hour Jan 7/15 vs. secondary , immunization: active vs. passive, phases of an Immune response, immune memory

Making an immune system: Hemopoiesis. Organs and cells 1 hour Jan 9/15 of the immune system.

Response to injury and : Innate Immunity: 1 hour Jan 12/15 Physical, chemical and cellular players

Innate Mechanisms of Immunity: complement , 1 hour Jan 14/15

Innate Mechanisms of Immunity: : initiation 1 hour Jan 16/15

Innate Mechanisms of Immunity: inflammation: 1 hour Jan 19/15 consequences

Cell language: Growth factors, , Chemokines and 1 hour Jan 21/15 their receptors

Real Life Translation: CASE STUDY #1 1 hour Jan 23/15

Adaptive immunity: Cellular and molecular players: 1 hour Jan 26/15 -presenting cells, MHC

Adaptive immunity: Cellular and molecular players: antigen 1 hour Jan 28/15 processing and presentation

Adaptive immunity: Cellular and molecular players: T 1 hour Jan 30/15 , T- antigen receptor

Adaptive immunity: Cellular and molecular players: co- 1 hour Feb 2/15 receptors

Adaptive immunity: Cellular and molecular players: B 1 hour Feb 4/15

Course Outline: MIMM214 3 lymphocytes, B-cell antigen receptor, (I)

Adaptive immunity: Cellular and molecular players: 1 hours Feb 6/15 antibodies (II), co-receptors

Generation of antigen receptor diversity in B cells 1 hour Feb 9/15

Generation of antigen receptor diversity in T cells 1 hour Feb 11/15

Lymphocyte development and 1 hour Feb 13/15

Real Life Translation CASE STUDY #2 1 hour Feb 16/15

MIDTERM EXAM: IN CLASS 1 hour Feb 18/15

General concepts on activation: MHC 1 hour Feb 20/15 restriction and allorecognition, costimulation and two signal model

General concepts on lymphocyte activation: Signalling 1 hour Feb 23/15 pathways

Leukocyte trafficking: adhesion molecules, homing 1 hour Feb 25/15 receptors

Profiles of expression and types of immune 1 hour Feb 27/15 response

STUDY WEEK March 2-6/15

Real life translation CASE STUDY #3 1 hour Mar 9/15

Immunity against and intracellular : How 1 hour Mar 11/15 does a cellular (Th1) immune response take place? theory (I)

Immunity against viruses and intracellular bacteria: How 1 hour Mar 113/15 does a cellular (Th1) immune response take place? (II)

Immunity against extracellular : How does a 1 hour Mar 16/15 humoral (Th2) immune response take place? (I)

Immunity against extracellular pathogens: How does a 1 hour Mar 18/15 humoral (Th2) immune response take place? (II)

Course Outline: MIMM214 4

Inflammatory (Th17) adaptive immune responses and other 1 hour Mar 20/15 profiles (Tfh, Th9, etc)

Negative regulation of an immune response: FcR, CTLA-4, 1 hour Mar 23/15 PD-1, activation-induced cell death

Negative regulation of an immune response: Regulatory T 1 hour Mar 25/15 cells and other mechanisms

Immune Tolerance 1 hour Mar 27/15

Immunological memory 1 hour Mar 30/15

Real life translation CASE STUDY #4 1 hour Apr 1/15

Review Session 1: Questions & Answers 1 hour Apr 8/15

Review Session 2: GRAND FINALE SESSION 1 hour Apr 10/15

FINAL EXAM 3 hour exam TBA

3. INSTRUCTIONAL METHOD

Interactive lectures with pro-active student participation and discussion.

It is highly recommended that students come to class having read the material for the particular lecture.

4. LEARNING OUTCOMES

After taking this course students should be able to:

 To use standard terminology in the field of Immunology  To list the cells and some of the molecules involved in immunity  To describe the organs of the immune system  To describe the main steps in the generation of cells of the immune system  To describe the basic mechanisms that provide innate immunity  To define inflammation and list the cellular and molecular players of inflammatory responses  To define cytokines and chemokines  To describe antigen processing and presentation  To describe antibodies and antigen receptors on lymphocytes  To explain cellular and molecular features of lymphocyte activation  To describe the main steps in the development of adaptive immunity  To explain cell-mediated adaptive immune responses against viruses and intracellular pathogens

Course Outline: MIMM214 5

 To explain -mediated adaptive immune responses against extracellular pathogens and parasites  To list basic mechanisms that regulate immune responses  To define from an operational point of view  To define, list mechanisms, and provide examples of  To explore the biological and clinical implications of immune mechanisms

5. COURSE MATERIAL

Janeway’s Immunobiology, 8th edition, Murphy, K. , 2012. Also available as iPAD textbook (inkling).

Textbook is required

6. COURSE EVALUATION

Midterm exam worth 35% of final mark and covering from first lecture to the lecture before Midterm exam.

Final exam worth 65% of final mark. The final exam will cover all the material of the course.

Both exams will be based on Multiple Choice Questions with 5 options, only 1 of which is correct. The questions in the final exam will be based on case studies.

7. MCGILL POLICY STATEMENTS

1) McGill University values academic integrity. Therefore, all students must understand the meaning and consequences of cheating, plagiarism and other academic offences under the Code of Student Conduct and Disciplinary Procedures” (see www.mcgill.ca/students/srr/honest/ for more information).

L'université McGill attache une haute importance à l’honnêteté académique. Il incombe par conséquent à tous les étudiants de comprendre ce que l'on entend par tricherie, plagiat et autres infractions académiques, ainsi que les conséquences que peuvent avoir de telles actions, selon le Code de conduite de l'étudiant et des procédures disciplinaires (pour de plus amples renseignements, veuillez consulter le site www.mcgill.ca/students/srr/honest/).

2) In accord with McGill University’s Charter of Students’ Rights, students in this course have the right to submit in English or in French any written work that is to be graded.

Conformément à la Charte des droits de l’étudiant de l’Université McGill, chaque étudiant a le droit de soumettre en français ou en anglais tout travail écrit devant être noté (sauf dans le cas des cours dont l’un des objets est la maîtrise d’une langue).

3) In the event of extraordinary circumstances beyond the University’s control, the content and/or evaluation scheme in this course is subject to change.

Course Outline: MIMM214 6

4) If you have a disability please contact the instructor to arrange a time to discuss your situation. It would be helpful if you contact the Office for Students with Disabilities at 514-398- 6009 before you do this.

5) McGill has policies on sustainability, paper use and other initiatives to promote a culture of sustainability at McGill.

6) Additional policies governing academic issues which affect students can be found in the McGill Charter of Students' Rights (available at www.mcgill.ca/files/secretariat/Handbook-on- Student-Rights-and-Responsibilities-2010.pdf)