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PHA 5755 Principles of Medical Microbiology, Immunology and Virology

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PHA 5755 Principles of Medical Microbiology, Immunology and Virology 1 PHA 5755 Principles of Medical Microbiology, Immunology and Virology Fall 2016 2 Semester Credit Hours Block 5 Course Purpose: The purpose of this course is to establish the student pharmacist’s foundation in the principles of medical microbiology, immunology and virology that will build upon the knowledge and skills gained in the Pathophysiology and Patient Assessment course sequence. In order to successfully manage a patient with an infectious disease, the student pharmacist must first understand the role of the host’s immunologic response and the burden of disease caused by clinically important pathogens. The content in this course will lay the foundation for the subsequent patient care series where the pharmacology and medicinal chemistry of anti-infective agents and pharmacotherapy of infectious diseases will be learned and applied to optimize the care of a patient. Course Faculty and Office Hours (See Appendix A for Who to Contact) Teaching Partnership Leader: Jacqueline Jourjy, Pharm.D., BCPS Email: [email protected] Office: 6550 Sanger Road, Orlando (UF Lake Nona Campus) Phone: 407-313-7031 Office Hours: By appointment Teaching Partners: Name Email: address Phone: Lindsey Childs-Kean, Pharm.D., MPH, BCPS [email protected] 727-394-6213 Kenneth Klinker, Pharm.D. [email protected] Veena Venugopalan, Pharm.D., BCPS [email protected] Bin Liu, Ph.D. [email protected] 352-273-7747 Juergen Bulitta, Ph.D. [email protected] 407-313-7010 Ashley N. Brown, Ph.D. [email protected] Academic Coordinator Name: Sarah Burgess Email: [email protected] Office: HPNP 4312 Phone: 352-273-5617 Office Hours: by email and appointment 2 This Course Will Prepare You to Perform the Following Activities Which the Public Entrusts a Pharmacist to Perform: 1. EPA A2. Interpret patient data, and identify medication-related problems and develop a prioritized problem list. 2. EPA A3. Formulate evidence-based care plans in collaboration with an interprofessional team. Utilize clinical guidelines in the development of a pharmacotherapy plan. Course-Level Objectives Upon completion of this course, the student will be able to develop and apply in a fundamental manner knowledge related to principles of medical microbiology, immunology and virology. Specifically: 1. Identify how the body’s immune system interacts with invading microbes including bacteria and viruses and the physiological and pathological consequences. 2. Associate the role of the normal human microbiota in the prevention of disease. 3. Describe the pathogenesis of bacterial and viral infections. 4. Apply knowledge of clinical laboratory techniques in the diagnosis of infectious diseases. 5. Interpret microbiological, immunological and virological laboratory data in the context of a patient’s clinical presentation and findings. 6. Correlate the major types of pathogenic microorganisms and the diseases they produce in humans. 7. Recognize infectious diseases for which an antimicrobial agent or vaccine would be indicated and select an appropriate agent based on spectrum of activity. 8. List the major classes of antimicrobial agents and their general spectrum of activity. 9. Identify mechanisms of microbial resistance and their potential impact on treatment. 10. Collaborate effectively with other team members to evaluate patient cases that require application of the principles of medical microbiology, immunology and virology. 11. Solve case-based problems that require application of the following principles: a. Interaction between the immune system and invading microbes b. Clinical bacteriology and laboratory diagnostics c. Pathogenesis, diseases, and antimicrobial agents of choice for gram positive microorganisms. d. Pathogenesis, diseases, and antimicrobial agents of choice for gram negative microorganisms. e. Clinical virology (laboratory diagnostics and common viral pathogens) Pre-Requisite or Co-Requisite Knowledge and Skills Pre-requisites: Completion of all Year 1 Pharm.D. Curriculum Requirements including milestones 3 Co-requisite: PHA 5163 L Professional Practice Skills Laboratory III Course Outline *Note: The Instructor Contact Hours listed below only designate structured learning that involves a faculty member. As noted by UF policy, for each 1 hour of “Instructor Contact,” students are expected to spend a minimum of 2 hours of additional time completing learning activities. Example: If a week has 15 hours of Instructor Contact, the student should plan on a minimum of 30 hours of additional study. Therefore, the typical student will devote 45 hours of effort to the course that week. Note this is a “typical” student – some students will find they devote less time and others will find need to devote more time. Date Mod. Unit Topic Learning Faculty Contact Recommended and Learning Resources will include Obj. Hours Dates for Viewing Unit Lecture Videos and readings. [hr.]a Videos Week 1 1 Module 1: Interaction Between 1-5 Liu 3.0 hr 8/15 (M) Immune System and Invading Microbes Watch: Immune defense – Part A Liu 40 min Watch: Immune defense – Part B Liu 70 min Watch: Immune defense – Part C Liu 45 min Watch: Immune defense – Part D Liu 30 min *Supplemental Readings Available – not required Week 1 2 Module 2: Clinical Bacteriology and 2-5 Venugopalan 3.25 hr 8/17 (W) Laboratory Diagnostics and Klinker Watch: Introduction to Microbiology Venugopalan 40 min Watch: Diagnosing bacterial Klinker 20 min infections – blood cultures Watch: Diagnosing bacterial Klinker 25 min infections – urine cultures Watch: Diagnosing bacterial Klinker 10 min infections – respiratory Watch: Diagnosing bacterial Klinker 15 min infections – wound Watch: Bacterial susceptibility Venugopalan 45 min testing Watch: Rapid Diagnostics Klinker 40 min Week 1 3 Module 3: Gram Positives 3-10 Jourjy and 3.92 hr 8/18 (Th) Venugopalan Read: Medical Microbiology Chapter 35 min 11: subsections on B. cereus, C. botulinum, C. tetani, and C. difficle 4 Read: Medical Microbiology Chapter 5 min 12: subsection on “Lipophilic Corynebacteria” Read: Medical Microbiology Chapter 10 min 21: subsections on “physiology and growth conditions for anaerobes”, "the polymicrobial nature of anaerobic infections", and "diagnosis of anaerobic infections" *Supplemental Readings Available – not required Watch: Staphylococci Venugopalan 40 min Watch: Streptococci Jourjy 50 min Watch: Enterococci Jourjy 15 min Watch: Bacillus Jourjy 15 min Watch: Listeria & Corynebacterium Jourjy 15 min Watch: Actinomycetes Venugopalan 10 min Watch: Clostridium Venugopalan 40 min 8/19 (F) 3 Active Learning Session 1: Gram Jourjy and 2 Positives Venugopalan JAX & GNV 1-10 Readiness Assessment Test #1 @ 8:30-10:25am Review Module Concepts as Needed ORL & GNV 11-20 Team Based Learning Application @ 10:40-12:35pm Plate Rounds/Application Activities and Discussions Week 2 4 Module 4: Gram-Negatives 3-10 Klinker, Childs- 5.0 hr 8/22 (M) Kean, Jourfy, and Bulitta Read: CDC Drug Resistance Threats; 25 min CDC Antibiotic Resistance Patient Safety Atlas (summary of results and map view) Watch: Enterobacteriaceae: E. coli, Childs-Kean 100 min Klebsiella spp, Enterobacter spp, Citrobacter spp, Serratia spp, Salmonella, Shigella, and the Tribe Proteae Watch: Non- Bulitta 40 min fermenters: Pseudomonas aeruginosa; Acinetobacter baumannii Watch: Non-fermenters: Jourjy 30 min Stenotrophomonas maltophilia; Burkholderia cepacia Watch: Gram-negative anaerobes Jourjy 15 min Watch: Pleomorphic bacteria Klinker 15 min requiring enriched media Watch: Bordetella Pertussis Klinker 10 min Watch: Francisella Teularensis Klinker 5 min Watch: Helicobacter pylori Klinker 10 min Watch: Neisseria Klinker 20 min 5 Watch: Chlamydia Klinker 10 min Watch: Legionella and Mycoplasma Klinker 15 min Watch: Yersinia, Pasteurella Klinker 15 min Watch: Mycobacterium Klinker 15 min 8/24 (W) 4 Active Learning Session 2: Gram Klinker, Childs- 2 hr Negatives Kean, Jourfy, JAX & ORL @ Readiness Assessment Test #2 and Bulitta 1:55-3:50pm Review Module Concepts as Needed GNV @ 4:05- Team Based Learning Application 6:00pm Case Application Activities and Discussions Week 2 5 Module 5: Clinical Virology, 3-10 Childs-Kean 7.0 hr 8/25 (Th) Laboratory Diagnostics, and and Brown Common Viral Pathogens Read: Medical Microbiology Chapter 110 min 38 Sections on Arthrophod-borne and Rodent-borne viral diseases) Read: Medical Micobiology Chapter 15 min 37: Rotaviruses section Read: Medical Micobiology Chapter 35 min 36: Polioviruses and Rhinoviruses Read: Medical Micobiology Chapter 60 min 40: Respiratory Syncytial Virus section, Mumps section Read: http://www.cdc.gov/zika/hc- 10 min providers/diagnostic.html Read: http://www.cdc.gov/zika/hc- 10 min providers/clinicalevaluation.html *Supplemental Readings Available- not required Watch: Viral Properties Brown 45 min Watch: Influenza Brown 30 min Watch: HIV Childs-Kean 30 min Watch: Hepatitis A, B, and C Childs-Kean 30 min Watch: Varicella/Zoster, HSV, CMV, Childs-Kean 45 min Epsein-Barr 8/26 (F) 5 Active Learning Session 3: Virology Childs-Kean 2 hr Readiness Assessment #3 and Brown JAX & ORL @ Review Module Concepts as 8:30-10:25am Needed Team Based Learning Application ALL GNV @ 10:40- Case Application and Discussions 12:35pm 8/26 (F) All Course Review on Big-Blue-Button All Faculty 2 hr Canvas Conversations Online 2:00-4:00pm 8/29 (M) Final Comprehensive Exam 8:00-10:00 6 Textbooks Required readings will be assigned from the following textbook available in AccessPharmacy: Karen C. Carroll, Stephen A. Morse, Timothy Mietzner, Steve Miller.
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