10/14/13 10:27 AM DISCOVERIES ADVANCING MEDICINE DISCOVERIES ADVANCING Do you or your loved one have Do you or your loved one Alzheimer’s?

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67th Street Gate 66th Street Gate 65th Street Gate 64th Street Gate East 63rd Street and Main Entrance York Avenue The Rockefeller University’s main entrance is at 1230 York York main entrance is at 1230 The Rockefeller University’s East Upper (at East 66th Street) on Manhattan’s Avenue Avenue York The university shares the intersection of Side. Sloan-Kettering and East 68th Street with Memorial Hospital/York-Presbyterian Cancer Center and New Medical College of Cornell University. Weill PUBLIC TRANSPORTATION York buses stop near the main entrance: the Two Buses: Avenue/57th Street crosstown (M31) and the 68th Street crosstown (M66). 6) to the Local (No. Avenue the Lexington Take Subway: Station and walk east. Avenue 68th Street and Lexington The FDR Drive can be exited at 61st/63rdCar: Street. York-Presbyterian Greenberg Garage at New Parking: east Hospital 212-746-1886 (entrance at 68th Street, Quick Park at 450 East 63rd Street Avenue). York of and 1st Avenue). (between York Clinical Research Support Office Avenue 1230 York NY 10065 York, New [email protected] www.rucares.org Rockefeller The Visiting Hospital University

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 Contact us at 1-800-RU-CARES or www.RUCARES.org. Contact us at 1-800-RU-CARES • FOR MORE INFORMATION • Disorders • • • The mission of The Rockefeller University CCTS is The mission of The Rockefeller University Hospital, founded in 1910, founded in 1910, The Rockefeller University Hospital, and medical has been the site of important scientific that have led to Nobel Prizes. including many discoveries, The Rockefeller University received a Clinical In 2006, from the National Award Science Translation and helps to support the Center which Institutes of Health, Science (CCTS). Translational for Clinical and The Rockefeller University Hospital The Rockefeller and Center for Clinical and Science Translational Study Categories: to accelerate the discovery of new knowledge about about to accelerate the discovery of new knowledge those human health and disease and to translate help people. discoveries into health practices that Advancing For more information about Discoveries at Rockefeller Medicine and Pioneering Discoveries University visit www.rockefeller.edu. 14-035_HSP_AlzheimersResearchBrochure_R05.indd 1 What is the study about? Who can be in the study? What is involved?

Researchers at The Rockefeller University are Individuals may be able to participate if they meet the The study consists of a series of visits to the conducting a clinical trial with the hope of following criteria: outpatient clinic at The Rockefeller University. improving cognitive functional performance • Between the ages of 60–85 years old These visits will generally occur Monday–Friday in patients with mild Alzheimer’s disease. • Have a clinical diagnosis of mild Alzheimer’s disease between the hours of 9 a.m.–4 p.m. • Are taking donepezil (Aricept®) at a consistent Study participation involves the following procedures: We are recruiting volunteer research participants dose of 5mg or 10mg per day for at least with a diagnosis of mild Alzheimer’s disease to • Neuropsychological tests 3 months • MRIs participate in a six month clinical trial of the drug • Have previously appointed a health care proxy Riluzole. Riluzole has been FDA approved for use • PET scans specifically designated for research consent and • Randomization of study drug in other disorders, but it has not yet been used in that this be documented. cognitive aging disorders outside of research studies • Blood samples such as this one. All individuals who participate will be compensated The investigators will use brain imaging technology for their time and efforts. to see if the drug can improve evidence of neuronal damage and prevent progression of cognitive Want more details? disability in patients with mild Alzheimer’s disease. Contact the Rockefeller University recruitment specialist at 212-327-8429 or at rucares@ rockefeller.edu

14-035_HSP_AlzheimersResearchBrochure_R05.indd 2 10/14/13 10:27 AM