Agenda NanoToxClass Kick-Off Meeting

Date: Thursday 14th & Friday 15th January 2016 Location: German Federal Instiute for Risk Assessment (BfR) Max- Dohrn- Strasse 8-10 10589 Berlin, Germany

Seminar Room B4063/ 4065, Please wait at the porter

Day 1: 14th January 2016

11:00 Opening of the meeting Welcome & Approval of Agenda

11:10 Tour de Table, Get to know each other

11:30 Overview of the project (Andrea Haase)

12:00 Formal Issues

12:30 Lunch Break (@ BfR canteen)

After lunch: short presentation & discussion about each WP (lead by WP leaders)

1:30 pm WP1 Develop criteria and tools for grouping Lead BfR (Christian Riebeling) 15 min presentation & 15 min discussion

2:00 pm WP2 NM characterization Lead IUTA (Thomas Kuhlbusch) 15 min presentation & 15 min discussion

2:30 pm WP3 Toxicity data and testing Lead UB & ISPUP (Anca Dinischiotu & Joao Paulo Teixeira) 15 min presentation & 15 min discussion

3:00 pm Coffee Break

3:30 pm WP4 Toxicity mechanisms Lead UNamur & UFZ (Olivier Toussaint & Martin von Bergen) 15 min presentation & 15 min discussion

4:00 pm WP5 Biokinetics, Biodistribution, Cellular Uptake Lead TAU (Rafi Korenstein) 15 min presentation & 15 min discussion

4:30 pm WP6 Overall data analysis, Grouping/ Classification Lead BfR (Andrea Haase) 15 min presentation & 15 min discussion

5:00 pm Discussion on NM selection for NanoToxClass Related to D1.1 (Month 2, End of January 2016) 10 min presentation by BASF (Wendel Wohlleben) 20 min discussion (lead by Thomas Kuhlbusch as WP2 leader)

5:30 pm End of Day 1

7:00 pm Dinner Location: Brauhaus Lemke (near castle Charlottenburg) Luisenplatz 1, 10585 Berlin-Charlottenburg http://www.lemke.berlin/schloss_charlottenburg/device.desktop/lang.de/

Day 2: 15th January 2016

9:00 Discussion on Grouping Criteria Related to M1 (Month 3, End of February 2016) - ECETOC Grouping approach, 10 min (BASF, W. Wohlleben) - other approaches & criteria (BfR, C. Riebeling) - discussion

10:00 Coffee Break

10:30 Selection of the cell model for in vitro experiments Related to D3.1 (M5) 10 min presentation (BfR, A. Haase & A. Bannuscher) discussion

11:00 Short Term Inhalation studies 10 min presentation by UB (Anca Dinischiotu) on status quo discussion on what is needed with respect to protocols, method transfer etc.

11:30 Lunch Break (@BfR canteen)

12:30 Integrated Omics strategies & Data analysis Status quo 10 min presentation by UNamur on transcriptomics 10 min presentation by UFZ on proteome & metabolom Discussion on strategies 20 min presentation by RKI on data analysis Discussion on strategies

2:00 pm Coffee Break

2:30 pm AOB

3:00 pm Summary & Conclusions

3:30 pm End of Meeting

How to reach BfR?

Further details at: http://www.bfr.bund.de/en/location_jungfernheide-128551.html

Arrival by rail / public transport Due to the many options and possible disruptions, we recommend that visitors view the latest connections at www.bahn.de, www.bvg.de of their choice, destination stop: "Jungfernheide Bhf (S+U), Berlin" or “Jungfernheide Bhf (Berlin) (S+U)”. To reach the institute buildings, take the exit in the direction of Tegeler Weg.

From the city centre: with the S-Bahn (urban railway) to Westkreuz and then onto the Ringbahn with S-Bahn Line 41. Or: from from Bahnhof Friedrichstraße with U-Bahn Line 6 in the direction Alt-Tegel to Wedding and then onto the Ringbahn with the S42.

From Tegel airport: direct with Bus X9 in the direction Zoologischer Garten (10 minutes).

From Schönefeld airport: S9 to Treptower Park and then onto the Ringbahn with the S42. Or: S45 to Südkreuz and then onto the Ringbahn with the S41. Other option: Bus X7 or 171 in the direction of Rudow, then with U-Bahn Line 7. Each trip takes approx. 1 hour.

Possible hotels

Plenty of options exist. 1) You may choose a hotel near Berlin main station (in city center, well connected via regional trains (RE), just one station from main station to Jungfernheide) For instance Motel One (single room 72.45 €) http://www.motel-one.com/de/hotels/berlin/hotel-berlin-hauptbahnhof/

2) You may choose a hotel near castle Charlottenburg (This is in walking distance to the institute, plan approx. 20 min)

For instance: Schlosspark-Hotel (single room 89 €) http://www.schlossparkhotel.de/

3) You may choose a hotel at Mierendorffplatz (U7) (Also near to BfR and well connected via U7, just one stop) For instance: Econtel Hotel (single room 68 €) http://www.amber-hotels.de/berlin-charlottenburg/

4) You may choose a hotel near airport (This is well connected to BfR via bus 109, just a few stops) Mercure Airport Hotel Berlin (single room 110 €) http://www.accorhotels.com/de/hotel-0791-mercure-airport-hotel-berlin- tegel/index.shtml

Any other hotel as BfR is well connected via public transportation urban railway (“S-Bahn”): S41, S42 metro: U7 bus: 109 or X9

How to reach dinner?

Brauhaus Lemke (near castle Charlottenburg) Luisenplatz 1, 10585 Berlin-Charlottenburg http://www.lemke.berlin/schloss_charlottenburg/device.desktop/lang.de/

Walking distance from BfR: approx. 1 km (15 min) S- Bahn (urban railway): station Westend (Ringbahn, S41/ S42) Metro: station Richard Wagener Platz (U7) Bus: Station Luisenplatz/ Schloss Charlottenburg (e.g. bus 109)