The NIH Record
U.S. Department December 9 Natlonal of Health 1980 Institutes and Vol. XXXII of Human Services No. 25 Health
NHLBI Receives Lasker Public Happy Holidays to Everyone Season's greetings to all from The NIH Health Award; Four Grantees Win Record staff and sincere wish~s for healthy, happy, and safe holidays. The Albert and Mary Lasker Foundation of enlist who received past support from the This is the last issue in December. The New York recently presented a public National Institute of General Medical Sci next Record w i ll be published Jan. 7, 1981. health award of $15,000 to t he National ences are winners of the Lasker Award for Heart, Lung, and Blood Institute in recogni their basic research contributions to de tion of a 5-yea r study of more than 10,000 velopment of recombinant D NA techno l men and women, most o f whom had high ogy. NIH blood p ressure. The four scienti sts, who will share the The Lasker Foundation cited the NHLBI $15,000 award, are Drs. Paul Berg, Stanl ey study as a "monumental landmark," in un N . Cohen, and A. Dale Kaiser of Stanford derstanding a d isease that affects millions University, and D r. Herbert Boyer of the of Americans. The study, ca lled the Hyper University of California at Sa n Francisco. tension Detection and Follow-up Program, showed that substantial reduction in Dr. Berg Shares Prize strokes, heart attacks, and deaths from Dr. Berg shared this year's Nobel Prize in heart disease could be achieved through Chemi stry with Dr. Walter Gilbert, another proper ca re of patients sufferi ng from even NIGMS grantee, and Dr. Freder ick Sanger, a mildly high blood pressure. British scientist. Improved diet, drug therapy, and other Dr. Berg's studies on the mechanisms and health care practices are employed accord regulation of gene expression have been ing to the patient's needs. Dr. Robert I. funded by NIGMS since 1966. His work on levy, NHLBI Director, accepted the award. viral tumorigenesi s has been supported for Three current N IH grantees-one of the past 6 years by the National Cancer In- whom is a 1980 Nobel laureate-and a sci- sti tute. (See LASKER AWARD, Page 4)
France's Griffuel Award for Cancer Research Is Presented to Dr. DeVita ftM~"1:\\""'-...-. France's prestigious Griffuel Award for outstanding achievement in cancer research 31 Employees Honored is being given this year to an American re By NIH Director searcner, Dr. Vincent T. DeVita, Jr., Direc tor of the National Cancer Insti tute. In recognition of "supe rior performance The prize i s awarded annually by the As or special efforts significantly beyond the sociation for the Development of Research requirements of regular duties," 31 persons on Cancer, Vi llejuif, France. have been honored by N IH Di rector Dr. Jacques Crozemarie, association presi Donald S. Fredrickson. dent, presented the prize of 180,000 French Dr. Fredrickson presented the NIH Di francs (approximately $41,000) to Dr. DeVita rector's awards in a ceremony held in the at a ceremony held in the UNESCO build Masu r Autidorium on Dec. 1. (See pages ing, in Paris, on Dec. 4. 8-9.) Dr. DeVita was honored for his contribu The First United States Army Band p layed tions to cancer chemotherapy, and the sig for the ceremony. nificant role he played in developing MOPP Major changes were made in the N IH Di the rapy, a combination of drugs that have rector's award this year: all N IH employees dramatically lengthened the survival rate of were eligible to receive the awards, and patients with Hodgkin's d isease. anyone was permitted to nominate an em In 1964, fewer than 10 pe rcent of those ployee. with Hodgkin's disease survived 5 years. Also, the award was allowed to be p re Today, almost 70 percent of patients with sented to other than current NIH personnel advanced Hodgkin's disease who receive During his research ca reer, Dr. DeVita has also under exceptional circumstances. □ (See DR. DEVITA, Page 15) received the Lasker M edical Research Award. The NIH Record Published biweekly al Bethesda, Md., by the Ed itorial Operations Branch, Division of Public Information, for the information of employees of the National Institutes of Health, Department of Health and Human Services, and circulated by request to writers and to researchers in biomedical and related fields. The content is reprintable without permission. Pictures may be available on request. The N fH Record reserves the right to make corrections, changes, or deletions in submined copy in conform ity w ith the policies of the paper and HHS.
NIH Record otflca Bldg. 31, Room 28-03, Phone 496-2125
Edllor Frances W. Davis s,~11 Wrllm Wi lliam 8. Reinckcns Joyce ~- McCarrhy
Stell Correspondents CC, Barbara Smakuta; DCRT, Mary Hodges; DPM, judy Fo u che; DRG, Sue Meadows; ORR, Barbara Menick; DRS, Ar• thur F. Moorei FIC, Toby P. Levin; NC I , Patricia A . Newman; The 1981 R&W Association membership drive begins with the traditional presentatio n of a mem NEI, Marsha Corbelt; NHLBI, Bill Sanders; NIA, Ann Dieffen be rship card to NIH Director Dr. Donald S. Fre drickso n (c-right). R&W preside nt Jerry Stiller (c-left) bach; NtAtD, Jeanne Winnic k ; NIAMDD, Linda Cross; NICHD, and other me mbe rs of the executive board (I to r)-Maurice Miles, Agne s Richudson, Margaret Pame la Driscoll; NI DR, Sally Wilberding; NIEHS, Hugh J. lee; NIGMS, Wanda Warddell; NtMH, Betty Zu bovic; NINCDS, Tho mpson, and Randy Schools- took pul in the presenlation. NIH employees who join in De· Doris Parker; NLM, Roger L. Gilkeson. ce mbe r will save $1 o ff the regular $3 me mbership lee. Cards can be obtaine d at the R&W Associa tion's activities desk in Bldg. 31, at all R&W stores, or through B/1/O representatives.
NLM's Holiday Hours Begin CC Patient Emergency Fund Short of Donations Now
For the Christmas and New Year's holi This year's annual Patient Emergency being treated. days, the operating hours for the National Fund Christmas Drive urgently needs dona Library of Medicine have been changed to: If everyone would give a dollar at _Christ tions from NIH employees. The fund, which mas time, next year's needs could be met. Wednesday, Dec. 24, 8:30 a.m.- 5 p. m. is entering its 20th year, is short of money. lhursday, Dec. 25, Closed The PEF, administered by the CC Social Contributions can now be accepted at the Friday, Dec. 2&, 8:30 a.m.-5 p.m. Work Department, assists patients with fi R&W Association's activities desk, Bldg. 31, Saturday, Dec. 27, Clo sed nancial aid that cannot be met with Federal Rm. 1A-18, and at all R&W Gift Shops. Gifts Wednesday, Dec. 31, 8:30 a .m.- 5 p.m. can also be sent to the CC Social Work De Jhursday, Jan. 1, Closed appropriations. Friday. Ian. 2. 6 : 30 a .m.- 5 p .m . Although CC patients receive cost-free partment, Bldg. 10, Rm. 7D-53, or call 496- Saturday, Jan. 3, 6 :30 a .m.-5 p .m. medical care, the high cost of living in this 2381 for more information. The NLM's regular hours for 1981 will be area may create a financial strain for family Already, t he R&W Association has helped 8:30 a.m. to 9 p.m., Monday through Fri members. out with a check for $3,000. In addi tion, CC day; on Saturdays from 8:30 a.m. to 5 p.m.; A contribution can make an enormous nurses, doctors, and others close to the and closed on Sundays. difference in the lives o f patients and those situation have dug down into their pockets who support them while they are at NIH and given. □
Training Tips Holiday Festivities Planned for CC Patients The fol lowing courses, sponsored by the Division of Personnel Management are To make the holiday season as festive as that date are tree-trimmi ng, a children's given in Bldg. 31. possible, the Clinical Center staff- with a Christmas party, and a hol iday dance. special assist from the Patient Activities The following afternoon, Santa will greet Deadline Communication Course Department-plan a variety of activities. patients and the CC staff at the annual pa Skills Starts last week, a shoppers' spree at White tient open house. 1/14 12/11 Report Writing Flint Mall initiated the round of festivities. Trips to the Washington Ca thedral and to Voice and Diction 1/5 12/17 These inc lude a trip to vi sit Santa at view the National Christmas tree and com Office Skills Montgomery Mall, a chapel carol service, munity lights are planned as well as Christ Basic Mag Card II 12/22 12/10 and a holiday concert of traditional and mas Eve caroling and a Welcome '81 party. seasonal music. As usual, bingos and feature films will be To learn more about these and other Dec. 17 is a full day. On the agenda for offered throughout the holiday season . □ courses in office and communication skills, contact the Training Assistance Branch, DPM, 496-2146. □ January 9 Is Deadline for Spring STEP Program
The application deadline for four modules STEP modules are designed primarily for being offered this spring through the Staff health scientist admini strators and man 'Coping with Holiday Blues' Training in Extramural Programs (STEP) is agement staff concerned w ith grant and Program Is Dec. 12 Jan . 9. contract programs. While enrollment pref The modules are Improving Interactions erence is given to personnel in the ex The Employee Assistance Program of Oc between the NIH and Grantee Institutions, tramural programs, applications received cupational Medical Service is presenting a Mar. 25; Politics of Health: 1981, Apr. 9-10; from other NIH employees will be consid special program on how to cope with holi Program Administration and Grants Man ered. day blues, Friday, Dec. 12 between noon agement : A Team Concept, Apr. 22-23; and and 1 p.m., in Bldg. 31, Rm. B2C-06. Contact Introduction to the Extramural Programs, For further information, contact Arlene Morri s Schapiro, 496-3164. □ May 7-8. Bowles, 496-1493, Bldg. 1, Rm. 209. D
Page 2 The NIH Record December 9, 1980 'Who Was This Man?' Irv Goldberg Says '30' to Outstanding Career Exhibit Opens at Library As Health Communicator With the stroke of a pen, Irving (Irv) W. Palmer Dearing, and former N IH As Goldberg wrote "30" to his long career as a sociate Director for Program Planning and "711#J?tl't:.1J ~'Y'OK. Government information specialist and Evaluation, Dr. Thomas J. Kennedy, Jr. health communicator. Irv, Director of the Although unable to attend, former Sur Division of Public Information, Office of geon General Luther L. Terry, wrote " Irv, .J~,~ -r~;t~1J~cV~ Communications, OD, si nce July 1970 will you know that Janet (Mrs. Terry) and I have retire Dec. 12 after more than 35 years of been some' of your greatest admirers for ~ Federal service. many years. We have appreciated your ex pertise and the contribution which you have Led Information Effort made to the success of the Pub lic Health '2 '- In that capacity, Irv directed and coordi Service. When I was Surgeon General, you nated N IH public information programs and were absolutely magnificent. I do ap activities, and provided staff advice to the preciate all you did for me .... Janet and I Office of the Director, NIH, and informa wish you great happiness and success in tion liaison wi th PHS/HHS and constituent your retirement." ~I agencies. During his career in Government infor ? ' mation, Irv served in numerous information and advisory capacities with the HHS, PHS, and NIH, beginning in 1947 as a member of the staff of the legendary Dr. Joseph W. Mountin, Associate Chief of the Bureau of State Services, PHS. H e later served as act ing information officer of the Bureau. From 1953 to 1965, Irv was deputy to the late Stewart Hunter, Assi stant to the Sur geon General for Information. He then be came staff assistant to HEW Secretary John W. Gardner, and acting public affairs assist Or. Korczak ant to HEW Secretary Wilbur J. Cohen. Prior to joining NIH, Irv was Associate There is currently an exhibit in the NIH Director for Print Media, Office of Public Library's display case at the Clinical Center Information, HEW. entitl ed "Who Was This Man?" The exhibit In retirement, Irv pl ans to spend winters is about Dr. Janusz Korczak, a Polish-Jewish in Boca Raton, Fla. , and summers in this physician, educator, and humanitarian, who area. Not one to confine his retirement to perished in the Treblenka concentration his two favorite pastimes-bridge and sun Mr. Goldberg plans to continue science writing camp in 1942 along with 200 orphans that he ning on the beach- Irv intends to keep ac in his retirement. had cared for in the Warsaw Ghetto. His livP in 1h'P. writing fiPl December 9, 1980 The NIH Record Page 3 Data Logger Device Records LASKER AWARD David E. Anderson, Foreman, Info. on Reusable Tape (Continued from Page 1) Retires After 28 Years Dr. Cohen currently holds two grants Data collecting by hundreds of N IH radi from NIGMS, one dealing with the replica David E. Anderson, equipment specialist ation (scintillation) counters is now being tion and transfer of bacterial plasmids and in the Maintenance Engineering Branch, Di simplified by a recording instrument de the other with gene expression in hetero vision of Engineering Services, retired in veloped at the Division of Computer Re specific environments. October after completing 31 years of Fed search and Technology. Dr. Cohen has also received NIAID sup eral service, over 28 of those years at N IH. The device, called a data logger, is easy to port for the past 13 years. Ors. Cohen and Mr. Anderson came to NIH in 19S2. Dur use, quiet, reliable, and completely elimi Chang took DNA from a eukaryotic source ing his early years in DES, he served as a nates the need to read and store data on of a prokaryote, Escherichia coli, a South refrigeration mechanic in the mechanical endl ess yards of paper tape. African frog, and successfully placed it in shop, Shops Branch, and later advanced to The logger records the data on a reusable the p lasmid where it replicated, part frog the position of foreman. magnetic tape cassette. A separate playback and part E. coli plasmid. This was the first In 1961, he w as transferred to the Office device relays the data to the central NIH piece of research of this type and repre of the Chief, MEB, where he served on computer (or to a local computer) up to 12 sented an important advance in recombin numerous projects: dealing with the under times faster than paper tape. Special soft ant DNA technology. ground utility distribution systems, the ware programs can then be implemented to waste water treatment plant of the NIH analyze the data automatically. Cell Communications Studied Animal Center, and many others. Dr. Ramon Tate, a former microbiologist, Dr. Kai ser is in his fourth year of NIGMS During World War 11 , Mr. Anderson spent but now a DCRT computer specialist, support. His research on the control of 3 years in the U.S. Navy. helped develop the prototype logger in 1977 multicellular development in myxobacteria In retirement, he plans to spend time in response to NIH researchers' requests is directed toward gaining an understanding farming, hunting, and fishing in his native for help in managing their laboratory data. of the molecular basis of communication northwestern Pennsylvania. At NIH, more than 40 of the CSL data log between cells. gers are successfully recording data Dr. Kai ser was also previously supported gathered from radio-immunoassays and by NIAID. His work the n was on an enzyme radioreceptorassays. These assays identify (ligase) which served as an annealing agent substances (such as hormones and their re with which a piece of foreign DNA can be ceptors) that have been radioactively "sutured" into a bacterial plasmid. This labeled. represented an important advance in gene Raw data thus collected is voluminous. In tic engineering. the past, data was read from paper tapes, Dr. Boyer's work on host-controlled manually transcribed, or tediously reduced modification and restr iction of DNA was by hand. supported by N IGMS from 1967 to 1975. □ According to Dr. Susan Hauser, elec tronics engineer and leader of the CSL data logger project, the logger is connected USDA Graduate School between the radiation counter and its nor mal output device, and it does not affect the Has Courses To Improve operation of either. One cassette tape can record approximately 2,000 lines of data and Job Skills or To Pursue is reusable after the data has been proc New Interests essed by a computer. The USDA's Graduate School schedule of A companion p layback device, which Fellow employees from NIH and HHS attended must be purchased separately, is used to 1981 winter quarter courses is now avail Mr. Anderson's farewell luncheon. read the data into a computer. The playback abl e. device costs about $2,000, but it can sup Hundreds of day, evening, and corre port many data loggers. Those interested in spondence courses will be offered this Urinary Infection Brochure obtaining a data logger may contact Dr. winter and are open to all those interested Susan Hauser, DCRT, Bldg. 12A, Rm. 2015, in improving job skills or pursuing new Explains Proper Management or 496-9343. interests. Some new courses are: Productivity: A An estimated 8.2 million visits to physi Management Problem; Great Decisi ons; cians each year are for infec tions of the uri Introduction to Technological Media nary tract. Of these, 6.7 million visits are (Audio-Visual Materials); Introduction to made by women, 1.5 million by men. On-Line Data Base Search Techniques; and These infections are among the most fre Consumer Law. quent causes of absenteeism in working Other subjects in the school' s extensive women, and are second only to absences curriculum include procurement, public from upper respiratory infections. affairs, editing, computer science, para Proper management of the disease is legalism, management, accounting, jour critical because the bacteria that invade the nalism, communication, foreign languages, urinary tract can cause serious damage to personnel administration, secretarial skills, the kidney, which may someti mes lead to and many more. kidney failure. Liberal studies include: Home Renova The National Institute of Arthritis, tion; Workshop in Career Planning and Job Metabolism, and Digestive Diseases, under Hunting; and Stress Management Through the auspices of its Kidney, Urology, and Creative Problem-So lving. Blood Diseases Program, has recently pub Mail registration ends Dec. 17. In-person lished a brochure on the symptoms, diag registration will be Jan. 5-10, 1981. nosis, causes, and treatment of uri nary tract For information, c lass schedules, and the infections. new 1980-82 Graduate School, USDA Copies of Understanding Urinary Tract Dr. H.iuser displays the compact data logger de Catalog, visit Rm. 265-A, National Press Infections are available from the NIAMDD, veloped al DCRT. The device is now an ilable Bldg., 52914th St., N.W., Washington, Bldg. 31, Rm . 9A-04, 9000 Rockville Pike, for use with radiation counters. D.C., or call (202) 447-4419. □ Bethesda, Md. 20205; (301) 496-3583.0 Page 4 The NIH Record December 9, 1980 The survey showed women are aware that New Breast Cancer Survey Finds Increase different treatments are available, and t hat nearly all believe there has been substantial In Understanding of the Disease progress made in treating breast cancer in th}! past 10 years. A national su rvey shows that public un killer of w omen, with about 110,000 new In the samples o f urban black and His derstanding of breast cancer has increased cases and about 37,000 d eat hs expected in ,>anic women, 53 percent of black women considerably over the past 7 years. 1981 . It is the leading cause of d eath for report practicing breast self-examination Ninety-six percent of women questioned women between the ages of 40-44. Ap once a month o r more, compared to 24 per had heard of the early d etection technique proximately 1 of every 11 women is ex cent of Hispanic women. Black and His of breast self-exami nation, compared to 77 pected to develop breast cancer at some panic women w ere generally less knowl percent of women su rveyed in 1973. time during her life. edgeable about the disease and its treat Women who are taught b reast self Respondents were more aware of in ments. examination by a doctor are more likely to fluential risk factors such as age, especially Overall, younger women, tended to be practice it than women who learn the tech being over SO, and having a family history of more kno wledgeable about b reast cance·r nique in other ways, the study shows. b reast cancer. However, 50 percent of the and consider it more of a threat to their This imp roves p rospects for a downturn respondents incorrectly believed that a health than older women. in deaths from breast cancer, said Dr. Vin bump or b ruise to the b reast can cause The survey suggested that men could play cent T. DeVita, Jr., National Canc~r Institute b reast cancer. an important role in dealing with the dis Director. But survey findings·also·suggest a The NCI survey showed that 61 percent of ease. Those men most knowledgeable need for further public education about the the women knew of X-ray mammography, about b reast cancer were found to have disease. an 18 percent increase in awareness since wives or partners who are the most thor About 40 percent of the women- 10 per 1973 . Few, however, had heard any negative ough in breast self-examination. cent more than the 1973 American Cancer publicity about mammography, such as risk Dr. DeVita attributed the increase in pub Society survey- say they use the technique from exposure to X-rays. Nineteen percent lic understanding of breast cancer to several monthly or more often, which is a practice of respondents reported having had a factors. Among these were: the mastec that both NCI and the ACS recommend. mammogram. tomies of two nationally known women, Studies also suggest that women practicing Betty Ford and Happy Rockefeller, who re BSE detect cancer earlier than they would Women Want to Decide ceived widespread media coverage. Public otherwise. awareness of the disease jumped. The survey was conducted in the fall of Dr. DeVita said the study indicates that As breast cancer survival rates increased, 1979 by Opinion Research Corporation of many women want to play a more active medical controversies, such as the value Princeton, N.J. Personal interviews were role in decisions affecting their health. and potential hazards of X-ray mammog used among a national probability sample of " Fifty-five percent said they would not give raphy, one-stage vs. two-stage diagnosi s 1,580 adult women in the United States and their doctor consent to remove a breast and treatment procedures, lesser surgery, 720 spouses or partners. Additional samples immediately following surgical biopsy if chemotherapy and radiation treatments, of black and Hispanic women also were cancer were discovered. and breast reconstruction received wide interviewed. " Instead," Dr. DeVita said , " they pref er coverage by the news media. Seventy-six percent of the women said to make the decision about cancer treat "The survey tells us clearly that the public cancer is their most serious health concern, ment in two stages. Furthermore, 90 per needs and wants to know more," Dr. De with more than half saying that breast cent said they wou ld seek a second medical Vita said. "While much progress is being cancer is the most worrisome of all cancers. opinion." made in breast cancer treatment, we still Concern about cancer far exceeded con An interval between a diagnostic biopsy are working toward an understanding of cern about other health problems, such.as and beginning of treatment allows time for causes. Meanwhile, the key to optimal sur stress, reported by 7 percent, and high a second medical opinion, exploration of vival is education, early detection and blood pressure, reported by 6 percent. alternative treatments, and emotional prep prompt, appropriate medical intervention." Breast cancer is the number one cancer aration if mastectomy i s needed. For further information, contact the NCI Office of Cancer Comm u nications. □ R&W Offers 1981 Ski Trips The NIH Ski Club, sponsored by R&W Association, recently announced its 1981 schedule: Killington, Vermont- Feb. 21-27; $389 price includes lodging at the Chal et Kill ington, lifts, 5 days of lessons, breakfast and dinner, and rai l transportation. Mont Tremblant, Canada-Mar. 8-14; $497 price includes lodging, 7 days of l es sons and lifts, air transportation, and three meals per day. Aspen, Colo. -Feb. 14-21; $579 p rice in cludes lodging, air fare, and 6-day lift tick ets. Blue Knob weekend-Feb. 6-8; price from $90 includes transportation, lodging, meals, lessons, and equipment. Came/back and Shawnee in tht: Poconos-Mar. 6- 8; price from $94 in cludes lodging, meals, lessons, and trans portation. NIEHS biologists Geraldine T. Carver (c) and Hayes W . Brown (I) received ;1.wards for their high Deposits are required for Killington and technical pe rformance in d eve loping an ultra structural/biomedic;1.I ;1. pproa ch to the cell ular toxicity Mt. Tremblant by Dec. 15, others by Jan. S. of metals. Wo rk-group lead er Dr. Bruce A. Fowler congratulates Ms. Carve r and Mr. Brown for the For further information, contact June quality o f the ir wo rk which has he lped the re nal intracellular function, and toxicology work gro up. Heyman in the R&W office, 496-6061 . D December 9, 1980 The NIH Record Page 5 Mutation Detection Technique Perfected Two New Members Join By NIEHS Scientists NIGMS Advisory Council Two new members have been appointed A new technique for detecting mutation The technique was developed mainly by to the National Advisory General Medical in living cells has been developed by scien Dr. Aftab S. Ansari, with assistance from Sciences Cou ncil : Dr. G. Tom Sh ires, Lewis Ors. Masroor A. Baig and Heinrich V. Mal tists at the National Institute of Environ Atterbury Stimson professor and chairman, ling, chief, from the laboratory of mental Heal th Sciences. The test could pro department of su rgery, Cornell University vide the means for identifying the effects of Biochemical Genetics. Medical College, and Dr. Lu ther S. For the p rocedure, the researchers used human exposures to toxic environmental Williams, professor of b iology and dean, agents. sperm from laboratory mice for a sample Graduate School of Arts and Sciences, Mutation is a change in the molecularly cell population and purified an antibody Washington University, St. Louis. coded messages in the DNA molecule of t hat would bind to a specific m utant protein Dr. Shires, an authority in trauma and each cell. Every coded message is necessary but not to a normal protein. The mutant burns, has been a consultant since 1965 to for perfect replication of replacement cells cells were then identified and counted by the Surgeon General of the Army. and new messages used in reproduction. fluorescent antibody technique. A member of many professional organi Usually mutation is a statistically rare While testing the technique, the inves tigators used procarbazine, a drug known to zations, Dr. Shires is president-elect of the event occurring naturally in only one cell in American College of Surgeons and past millions. It can be fatal or biologically cause mutation in spermatogonia, and found an increase in the frequency of president (1979-80) of the American Surgi harmful to the single cell or developing cal Association. embryo that happens to inherit the mutated fluorescently stained cells with increasing He also serves as associate editor of Ad DNA. dose. The system can detect one mutant vances in Surgery and is a member of the For instance, a degree of spontaneous cell in a million normal cells. editorial boards of a number of professional mutation can be caused by natural radia The scientists concluded that "such a journals. tion. However, some man-made chemi cals dose versus resportse relationship with a can also cause an increase in mutation i nci known mutagen is an indication that the Dr. Williams' research interests center on dence and these have been detected by mi 'stained' sperm have originated through control of gene expression, microbial crobe culture screening tools. mutation in sperm." physiology, a.nd molecular biology, and he Mutation detection in higher animals had Their research results are to be published is author of more than 40 publications in his field. before been difficult because a "marker" in the Proceedings of the National Academy trait attributable to a single gene could not of Sciences, 1980, titled, An Approach to In He has been a consultant to the NIGMS be identified. The NIEHS scientists, how Vivo Germinal Mutation Detection With Director since 1972, and since 1974 has ever, feel that their new technique accom 'Mono'-Specific Antibody Against Lactate served as a consultant to the Minority plishes this. Dehydrogenase-X. Biomedical Support Program of the Division The ability to precisely detect mutation is A conservative estimate for accurate cor of Research Resources. significant because it will enable research relation is 80 percent, and many scientists Dr. Williams is a former member of the ers to distinguish the correlation between feel it could be higher. Therefore, depend HHS Recombinant DNA Advisory Commit chemicals and agents causing cancer from able detection for mutagenicity could be tee and a current member of the National those causing mutagenicity, as seen another key to determining which-agents Research Council's Postdoctoral Fellowship through microbe tests. cause cancer. □ Evaluation Panel. □ Marge and George Graham's Retirement Ends Over Half Century of Two Successful Careers variety of positions there, and in his last post before coming to NIH served as tech nical advisor to the Accounting Division. At NIH, he was instrumental in starting electronic pri nting. A successful copier management program and introduction of the copy center concept at NIH were de veloped by Mr. Graham. In addition, he established a structured training plan that permitted both plant and clerical employees to be promoted into managerial positions. A member of many professional printing organizations, Mr. Graham is also one of 50 certified graphics communications manag ers in this country. Marjorie Graham retired from the posi tion of assistant to the DAS Director. She began her Federal career as a clerk-steno in DAS in 1962, gradually advancing in her career. Her position involved her with overall management practices and Government regulations that included: a continuous re Marge (I) and George Graham (r) are joined by long-time friend from the G.P.O., Aaron S. Blauer. view and evaluation of policies, staffing, functional conflicts resolution, and solving Over 160 friends and relatives attended a printing officer; prior to that, he was head of internal problems. retirement dinner held last month to honor of the Printing Unit. The Grahams have been members of the George and "Marge" Graham, who retired Mr. Graham worked for 26 years at the NIH Toastmasters' Club for many years. from key posts in the Division of Adminis Government Printing Office before coming "Marge" Graham has also served on the trative Services. to NIH. He began his printing career after R&W Association's board of directors. George Graham's Federal career spans 40 graduating from the GPO Apprentice In retirement, the Grahams plan to travel, years. Since 1972, he has been the NIH School as a journeyman printer. He held a do volunteer work, and pursue hobb i es. □ Page 6 The NIH Record December 9, 1980 Camera Club Photo Competition Winners Susan- 1st Place B&W-C. Clark Taxi-3rd Pl ace B&W-C. Clark COLOR PRINTS (b7 e ntri Delhi's Red Fort- HM- J. Bo retos Stairwell- HM- C. Cluk Po rtr.ait of Curiosity- HM- L. Gorden December 9, 1980 The NIH Record Page 7 NATIONAL CANCER INSTITUTE NIH Ruth 8 . G11ton, biological laboratory technician, Laboratory of Biochemistry, Division of Cancer DIRECTOR'S Biology and Dlagnosis-" Whose reliable, effi cient, accurate work as a laboratory technician has been critical to the success of research by AWARDS leading NIH scientists over a 25-year period." Janice Romanoff, administrative assistant, DCBD-"The Immunology and Cancer Centers Programs of the National Cancer Institute owe much to her extraordinary administrative and sec- Ms. Collins Mr. Pollack retar/al skills." NATIONAL HEART, LUNG, AND BLOOD INSTITUTE Annie R. Col/Ina. public health educator, Office of Prevention. Education. and Control, Health Education Branch -"For creativity, sensitivity, and perseverance in leading the development of hypertension education and control efforts for minorities and the disadvantaged." Lewis S. Po/laclc, chief, Contract Management Mr. C ute r Branch -"For insistence on maximum competl- Ms. Lie be rman tion in the contract process and vigorous protec tion of the contract negotiation and award system for the NIH." Mr. DeKorte Mr. Habel Dr. Lo riaux Ms. Bagley OFFICE OF THE DIRECTOR NATIONAL INSTITUTE OF ALLERGY Ms. Riley Mr. Bonner AND INFECTIOUS DISEASES Jame, V. Carter, motor vehicle operator, Office of Adminlstration -"The Director's 'Ambassador Rose Lieberman. research microbiologist, Lab of Good Will' in the service of all NIH." oratory of lmmunology-"Who has earned Inter national recognition for pioneering work in dis Francis T. DeKorte, electrician, Division of En covery and mapping of complex genes and the gineering Servlces-"Who brings us light and respect of colleagues at NIH for exceptional con energy with dedication and superior technical tributions as a scientist." skill." NATIONAL INSTITUTE OF ARTHRITIS, Kurt Habel, chief, Program Planning Branch, Di vision of Program Analysis, Office of Program METABOLISM, AND DIGESTIVE Planning and Evaluation -"For his key role in the DISEASES highly useful research planning reviews and in developing principles for strengthening NIH's Ms. Dozier M r . Moore Dr. Letter B. Sa/ant , associate director for Dia planning capabilities." betes, Endocrine, and Metabolic Diseases-"An articulate spokesman whose scientific insight and Glorla T. RIiey, acting chief, Labor Management commitment to research on diabetes has en Branch, Division of Personnel Management hanced and united that effort within NIH and " For substantial contributions to NIH administra among other Federal agencies... tion of labor contracts and for service as re spected advisor to managers and union officials NATIONAL INSTITUTE OF CHILO alike." HEALTH AND HUMAN DEVELOPMENT A group of three were honored: Dr. D. Lynn Lor/aux, chief, Developmental En Larry Bonner, consultant, work improvement, docrinology Branch-" For admired leadership, DMP- ability as a teacher, and his genuine concern for patients and fellow workers. " Delore, Dozier, EEO specialist, Division of Ad Ms. Gaston Ms. Rom,moif ministrative Services - NATIONAL INSTITUTE ON AGING Jerry E. Moore, management analyst, Division of Shirley Bagley, health scientist administrator, Management Polley- Social and Behavioral Science Program - " Whose dynamic leadership, initiative, and pro Each received the award "As a member of 'The fessionalism were critical to the successful Project Team ' for wisdom and sensitivity in en launching of the social and behavioral science listing the enthusiastic support of staff in en programs of the NIA." hancing productivity and morale in the Printing and Reproduction Branch." Page 8 The NIH Record December 9, 1980 NATIONAL INSTITUTE OF DENTAL Roger Fa/man, computer specialist, CCB- " The father of Wylbur -that ubiquitous, constant, and RESEARCH efficient servant that benefits researchers and managers in NIH laboratories and offices." Barbara Y. Iba, EEO specialist-"For effective service on numerous NIH-wide committees to foster equal opportunity and for essential contri DIVISION OF RESEARCH GRANTS butions to development of the NIH Child Care Program." Joseph A. Sracl CHILD DAY CARE CENTER Sherrie Rud/cl<, director, NIH Preschool-" Who has made the NIH preschool a model by creating a loving, stimulating and secure environment for Mr. Fajman Mr. Brackett many children of NIH employees." CLINICAL CENTER John H. Belts, elevator operator-" For cheerful assistance and outstanding service over 27 years to patients, visitors, end staff in the Clinical Cen ter." Ms. Iba Ms. Mullen Jesse J. Ferguson, Jr., supervisory administra tive technician, Admissions-"For dedicated service to patients in NIH care and for teaching, by personal example, his young co-workers im portant lessons in living." Doris Marshall, head nurse, Unit 2B-"Whose Ms. Bynum Mr. Corsey able services es a professional end a preceptor / have been critical to NIH in maintaining its role es the foremost innovator in cancer nursing." Walter E. Moten, chief, Environmental Sanitation Control Depertment-"For leadership in instilling Dr. Wexle r Mr. Cullen staff awareness and responsiveness in dealing with the complex problems brought on by the vast amount of construction within and surround ing the Clinical Center." Linda Truitt, public information specialist-"For personally representing the NIH with intelligence, sensitivity, and unfailing courtesy In greeting and Ms. Snowden Ms. Ruddick escorting the many individuals and groups who are our special guests at the Clinical Center." DIVISION OF COMPUTER RESEARCH AND TECHNOLOGY Mr. Be tts Mr. Ferguson Richard J. Feldmann, computer specialist, Com puter Center Branch-"For development of 'molecular graphics,· which has made it possible to see the unseen and to study the three dimensionel structure of biologically important Rrotein molecules." December 9, 1980 The NIH Record Page 9 Dr. Tsu Prescribes His Own Rx for a Long Life First Black Belt Awarded To NIH Judo Club Student; Others Also Promoted The NIH Judo Club has had a first among its members. Mark Dantzler, a long-time club member and judo student became the first member to have conferred upon him a first-degree black belt shodan by the U.S. Ju do Federation. Another club member promoted was Taffy Harrison, who qualified for a brown belt lkkyu at the same promotion rounds held at Stephen Decatur Junior High on Nov. 7-8. In October, other NIH Judo Club mem bers were promoted at the Washington Judo Club in Alexandria, Va., to Gokyu or 5th degree student white belt: K.F. Chow, Mike Hazard, and M.J. Waxtal. Promoted to green belt or 4th degree student was Adam Schutz and Jim Slemp. A beginner's judo c lass will start in January. For further information call Sue Stewart 496-5586 . □ Reverend Tsu particip.ites in a lung experiment at the Gerontology Research Center. Dr. Donald Ware Selected Although vitamin E, gerovital, and cellular sciences in 1912, he returned to China As Harvard Macy Fellow therapy have all been touted at o ne time or where he was ordained a Baptist minister. another as having pote ntial anti-aging ef Dr. Tsu recalled some prejudices he en fects, their efficiency has not been scientifi countered in the U.S. during his college ca lly proven. Meanwh ile, Rev. Andrew Ts u days. prescribes his own "One of the to ughest things for me was Rx for longevity, ~----~ to get a haircut back then," he said. Re " To be useful in verend Tsu exp lained that the Irish d isl iked whatever you do." the Chinese, and since most of the barbers The Reve rend Tsu in New York City then were Irish, they re should know. He is fused to serve him. 95 years o ld. " I had to go all the way to Chinatown just Before continu to get my hair cut," he added, imitating a ing his tests as a barber at work. "Can you imagine that?" volunteer in the National Institute Reverend Tsu made certain to mention, on Aging's Balti however, that America has made great more Longitudinal changes and progress over the years. "This Study of Aging at Dr. Tsu is the land of opportunity," he remarked. the Gerontology Research Center, Revere nd One of h is sons, he said, is minister of an Tsu paused for a few moments to reflect on all-white church in California. "Can you imagine that?" his life and personal philosophies. for his achievements as chief of NHLBl's High " Life is heavy, time is heavy," said the In 1950, after nearly 40 years of ministry in Blood Pressure Demonstration Program, Or. smooth skinned nonagenarian who appears his homeland, Reve rend Tsu returned to the Ware received a plaq ue of appreci.ition lrom far younger than his chronological age. U.S. to retire. He keeps quite busy repair the Black Hypertension Network. "Occupy your life with usefulness. Make ing broken jewelry for his lady friends at a the most of it," he proclaimed, shaking a Methodist retirement home in Wilmington. Dr. Donald Ware has been selected as a finger. In addition to "always being useful," Dr. Josiah Macy Fellow in Health Policy at Har A native of China, Reverend Tsu now re Tsu's self-proclaimed formula for a long life vard University. The fellowship is part of the sides in Wilmington, Del. He came to is to follow a proper diet, to exerci se, to live Fo undation's program of awarding faculty America in 1909 and attended college in in a good environment, and to have scholar sabbaticals for recognition of aca New York City. friends. " These are the great secrets of demic excellence. After receiving his Ph.D. degree in social time," he said in closing. □ President of Student Association Dr. Ware received his M.D. degree from Instrumentation Symposium R& W Has Tickets for Many Events , the University of California, San Francisco, Dec. 10-12 and his master's of public health from the R&W has tickets for the following events: ! University of California, Berkeley. While The NIH Instrumentation Symposium, American Ballet Theatre performs " The attending medical school he also served as sponsored by the Biomedical Engineering Nutcracker" - Kennedy Center; Dec. 26; president of the Student National Medical and Instrumentation Branch, Division of ticket price, $19. As sociation. Research Services, will be held at the Masur Pinchas Zukerman, renowned violini st A medical advisor to the NHLBI High Auditorium, Dec. 10-12, Wednesday Kennedy Center; Jan. 31; ticket price, Blood Pressure Demonstration Program, he through Friday, from 9 a.m. to noon and $10.50. has been at NIH for 4 years. □ from 2 to 5 p.m. each day. Order tickets at the R&W Activities Desk, For programs (including abstracts of talks) Bldg. 31, Rm. 1A-18. D or further information, call 496-5771. □ Page 10 The NIH Record December 9, 1980 Christmas Holiday Concert Power Plant Foreman Retires; Plans To Build Airplane Features Choral Groups The annual holiday concert and Christmas carol sing, sponsored by the R&W Associa tion, will be held on Wednesday, Dec. 17, beginning at noon in the Masur Auditorium. The N IH Si ngers and the NIH Madrigal Singers will present a varied program of choral music, including portions of the Viv aldi "Gloria." Following the concert, Ben Fulton will lead a carol si ng-along. This festive program is open to all NIH 1 employees, patients, and guests. For further information, call Dr. Lewis M. Norton, 496-6037. □ R& W Sponsors Antique Sale At FAES House Dec. 14 and 21 The Recreation & Welfare Association i s sponsoring an exhibition and sale o f gold jewelry, silver, gemstones, objects of art and miscellaneous antiques and collecta NIH Power Plant chief John Vilgos (I) presents Mr. O 'Brien with an HHS certificate of merit. bl es offered at dealer prices at the FAES house (corner of Old Georgetown Road and The 28-year career of the man who kept equipment running smoothly. He l ed a Cedar Lane) on Sunday, Dec. 14 and N IH cool in the summer and comfortably maintenance crew that kept a constant sup Dec. 21 , from 11 a.m. to 7 p.m. warm in the winter has come to an end with ply of power to NIH's heating and air con In addition, there will be offerings of an October retirement. ditioning equipment. Japanese prints, estate jewelry, and oriental James E. O 'Brien, NIH Power Plant fore artifacts, including rugs. man, came to NIH in 1953 when construc Now retired, Mr. O' Brien, who i s acer The $1 admission per adult, entitling the tion was nearing completion and he helped tified pilot, plans to complete the construc entrant to a free drawing for prizes, will be to put the p lant into operation. tion of an airplane that he has been building donated to the Patient Emergency Fund. □ He was responsible for keeping lhe at his Wheaton home over the last few Power Plant's boilers and refrigerati on years. He hopes to fly it soon. D Christmas Is No Holiday From Crime, Say Police CC Volunteer Interpreter Honored by Brazil for Work One way to avoid becoming a Patricia Shepard, a Red Cross volunteer Christmas-time crime sta ti stic is to follow working at the Clinical Center as an in the suggestions provided each year by the terpreter, was honored last month by the N IH Protection and Secu rity Branch. To Brazilian Military Commission for her in keep from being on a thief's Christmas valuabl e services in communicating with shopping list: Portuguese-speaking Brazilians being • While out shopping, when you park treated at the CC. your car, roll up your windows. Remove all She has volunteered her language attractive items that might encourage a thief speaking services for the past several years, to break in. and is lhe only Portuguese-speaking in • Do not carry large amounts of cash. terpreter. Although only a volunteer, Mrs. • Do not leave house or automobile keys Shepard has been called upon to work up to lying around where they might be stolen. 60 hours a month interpreting. Besi des • Women should either carry their purses Portuguese, she also speaks French and with them or place them in a locked cabinet Spanish. She has lived in France, Belgium, or desk. and Brazil as the wife of a U.S. Foreign • Carry keys, wallets, and other small val Service officer. uables on your person rather than l eaving them in a coat on a rack. Colonel Hely Rego, chief of lhe Brazilian • Transistor radios, televisions, tape rec Military Commission, presented a plaque orders, and cameras should be kept under and spoke of the deep appreciation that lock and key. These are popular items on Brazilians have for Mrs. Shepard's work in any thief's list. Such items ca n be engraved assisting military personnel and civilians staying at the CC. Mrs. Shepard (c) accepts a plaque from Brazil's easily with an owner's social security or Htely Rego (r) for her service to Brazilians being driver's license number. An engraving tool When accepting the plaque, Mrs. treated at the CC. Her husband, William, wa s is available at the R&W Association's Ac Shepard explained that she did not want present at the cere mony. tivities Desk, Bldg. 31. anyone to think that it was being given to • During working hours do not leave your along with Mrs. Shepard's husband W illiam, her for speaking Portuguese. " I think what her brother, Dr. Wales Craven, and his office unattended. we are praising today i s communication wife, Dr. Elizabeth Craven, attended the re • Suspicious strangers should be re with the sick, which goes beyond the fron ception held after the ceremony. ported immediately to the N IH Police by tiers of your country and mine." dialing 496-5685. □ Brazilian flags were given to them, and Betty Schwaring, CC director of volun roses were presented to Mrs. Schwering teers and volunteer interpreter services, and Mrs. Craven. D December 9, 1980 The NIH Record Page 11 Register Now for FAES Graduate School Classes for the FAES Graduate School will begin on Feb. 2, and registration may be made now through Jan. 9 by mail, and in person from Jan. 22 through Jan. 28. Tuition i s $32 per credit hour, and courses may be taken for credit or audit. Courses qualifying for Institute support as training should be cleared with supervisors and ad ministrative officers as soon as possible. Courses offered include biochemistry, genetics, physics, mathematics, pharmacol ogy, toxicology, nursing, psychology, lan guages, and courses o f general interest. Credits may be transferred to other in stitutions for degree work, and many o f the courses are approved for AMA category I credit. The evening classes sponsored by FAES will be given on the NIH campus. A regis tration form must accompany the check or training application. Schedules are available in the Graduate School office (bookstore) in the Clinical Center, Rm . B1-L-101. For more information, call 496-5272 . □ Epidemiology of Aging Publication Now Available Former tennis pro and Wimbledon champion Arthur Ashe, who had a heart attack at the peak of his career, is now a public spokesman for the National Heart, Lung, ;and Blood Institute educational The proceedings from t he Second Con program on cardiovascular risks. This poster will be shown throughout the country at airports, on ference on the Epidemiology of Agins are buses and subways, and as public service print ads in national magazines. Another version of the now availabl e. The conference was a col same message will be broadc;ast on 7,000 radio and television stations beginning in January. The laborative effort by the National Institute on Medicine for the Layman lecture series booklet on Heart Attacks, which was developed by the CC Aging and the National Heart, Lu ng, and Informatio n Office, is be ing offered fre e to the public. Blood Institute for an effective research program which will extend beyond the study of how aging relates to the incidence Borden Award Presented NLM Offers 10 New Lit. Searches and p revalence of diseases occurring in To Dr. Donald F. Steiner later life. Ten new bibliographies may now be re quested from the Nati onal Library of The major areas of discussi on in the pub In recognition of his extensive work in Medicine's Reference Section. lication are: definitions of aging; b iomedi the biosynthesis of insulin, Dr. Donald F. cal correlates of aging; social, p sychologi Steiner, associate director of NIAMDD's These Literature Sea rches, part of a series cal, and functional correlates of aging; D iabetes Research and Training Center at of printed bibliographies on subjects of demographic trends and healt h care impli the University of Chicago, was recently current interest, were produced through cations; and a summary which makes rec presented the 1980 Borden Award of the NLM's computer-based system, MEDLINE. ommendations for future research. Association of American Medical Colleges. They are available w ithout charge. Copies may be obtained by wri ting to: In 1965, Dr. Steiner showed that insulin i s A complete list of availabl e titles appears National Institute on Aging, Bldg. 31, Rm . made by way of a larger molecule, called a in each issue of Index Medicus and Ab 5C-36, Bethesda, Md. 20205. □ precursor or prohormone, which contains ridged Index Medicus. the complete insulin molecule within it. When requesting Literature Searches, NIEHS and Union Local This discovery opened up the field of hor p lease include title and number, enclose a Sign New Agreement mone precursors, providing valuable infor self-addressed gummed label, and mail to: mation about the production of human Literature Search Program, Reference Sec hormones and secretory proteins. tion, National Library of Medicine, After more than a year of negotiations a Bethesda, Md. 20209. new agreement between N IEHS and the Hi s discovery has since led to significant American Federation of Government Em improvements in the purity of insulin avail ployees AFL-CIO Local 2923 has been signed able for treating diabetic patients. It also LS 80-1 Passive smoking. Ja nuary 1972 through September and approved by the Public Health Service. p rovided a basis for the production of insu 1980. 162 citations. lin in the laboratory. LS 80- 2 Spinal cord i njuries t herapy and rehabdltation. The agreement, replacing a 1973 pact, J•nuary 1977 through October 1980. 251 c l1atlons. establishes a joint labor-management com LS 60-3 Elemental d iet. January 1975 through October 1980, mittee that will meet quarterly to discuss Work Leads to Genetic Engineering 170 citations. mutual concerns. Using genetic engineering techniques, LS 80-4 Cardlopulmonary Resuscitation (CPR). January 1977 1hrough Oc1ober 1980. 112 citations. It also calls for an increased number of scientists are now implanting proinsulin LS 80-5 Drugs and the elde rly. lanuary 1977 1hrough October union stewards for better employee repre producing genes in bacteria wh ich will p ro 1980. 287 c italion s. sentation and provides AFGE office space duce p ure insulin in large quantities. LS 80-6 Psoriasis therapy. January 1977 through October on the NIEH S campus. The Borden Award is given annually by 1980. 299 c11a1 ions in English. LS 80-7 Reyt:'i. ~yndrome, January 1975 t hro ugh O ctober Other provi sions include up to 280 hours the AAMC in conjunction with the Borden 1980. 194 citationc.:. of admini strative leave for union officials to Company Foundation for "outstanding re LS 80- 6 Vinyl chloride t oxicology. January 1977 through Oc• receive mutually beneficial training. and up search in medicine by a member of a medi 1ober 1980. 245 cila1lons. to 30 days I eave or leave without pay for a ca l school faculty." A committee of noted LS 80-9 B~n:zene toxicology. January 1977 through Sep tember 1960. 164 citations. male employee to assist his wife and fam ily medical educators from across the nation LS 80-10 Amantadrne and influenza. la nuary 1975 1hrough at home when a new baby is born. □ selects the reci p ient. □ Oc1ober 1980. 114 ci1ations.O Page 12 The NIH Record December 9, 1980 Oxygen Therapy Comparisons Find Continuous Dr. Jacob Robbins Shares 24-Hour Treatment Best for Lung Ailments Am. Thyroid Asso. Award Dr. Jacob Robbins, chief, Cl inical Endoc A collaborative study, compari ng 12-hour For patients followed for 2 years, princi rinology Branch, NIAMDD, was recently nocturnal and 24-hou r oxygen therapy for pally those who joined at the beginning of named co-recipient of the American Thyroid patients with severe respiratory impairment, the study, mortality was 22.4 percent and Association's Parke-Davi s Distinguished has found the round-the-clock therapy 40.2 percent, respectively. By the end of the Lectureship. more beneficial in prolonging life. study, 31.5 percent of all participants had Drs. Robbins and Mortality and the effects on the died. A lvin Taurog, Uni physiologic and neuropsychologic functions Dr. Claude Lenfant, director of the Divi versity of Texas affecting the quality of a patient's life were sion of Lung Diseases, said: "The results of Southwestern examined in the study. this clinical trial indicate that mortality is Medical School, The collaborative study involved six twice as great among patients in nocturnal Dallas, were medical centers and 203 volunteer patients oxygen therapy as among those in continu awarded the $1,500 suffering from chronic obstructive lung dis ous therapy. prize at lhe 56th ease. Their disease was at a stage where the " While nocturnal oxygen therapy may be annual meeting of lung could no longer supply the body with less expensive, it is not as effective in ex the ATA in San enough oxygen to meet its metabolic re tending life in patients with this particular Diego in quirements. lung disease." November. Between 25,000 and 500,000 Americans In regard to other aspects of the study, Chief of the Dr. Ro bbins require oxygen treatment for this stage of Dr. Lenfant said: "The differences are less Clinical Endoc chronic lung impairment which is almost clear. There is evidence that patients with rinology Branch since 1963, Dr. Robbins was always fatal. the severest respiratory impairment bene cited for his "outstanding contributions to The Division of Lung Diseases of the Na fited most from the continuous oxygen numerous basic research and clinical as tional Heart, Lung, and Blood Institute ini therapy. pects of thyroidology over many years." tiated the study in 1977. " Although not all data from the st udy His research accomplishments include Preliminary evidence from earlier investi have as yet been analyzed, it is anticipated the identification and detailed analysis of gations indicated that when oxygen was that it will contribute considerably lo our thyroxi nebinding proteins in the blood and administered for only 12 hours nocturnally understanding of the u I ti mate role oxygen abnormalities in the thyroid protein, (instead of a continuous 24 hours), it therapy may have in the treatment of lung thyroglobulin. He has also made contribu seemed to prevent oxygen deficiency com diseases. tions to the diagnosis and treatment of plications such as increased numbers of cir "For exampl e," Dr. Lenfant continued, thyroid cancer. culating red blood cells and elevated pres " there are indications that oxygen therapy Formerly with Cornell University Medical sures in the pulmonary artery. may slightly improve neuropsychologic College and the Sloan Kettering Institute, Since continuous therapy is both costly conditions and the patient's perception of Dr. Robbins joined the Cli nical Endocrinol and inconvenient for ambulatory patients, his or her quality of life. These indications, ogy Branch in 1954. and because oxygen deficiency is especially however, need further verification." He is former director and president of the severe during sleep, 12-hour oxygen ther The centers participating in the trial were: American Thyroid Association and past apy would be a feasible alternative if it were Henry Ford Hospital, Detroit; Northwestern editor-in-chief of Endocrinology. □ as effective as continuous therapy. University, Chicago; the University of Man The patients were randomly assigned to itoba, Winnipeg; the University of Califor either the continuous or the nocturnal oxy nia and the Scripps Clinic Research Foun gen therapy program. Because not all par dation, San Diego; the University of Col ticipants began the study at the same time, orado, Denver; and, the University of results at the end of the first year were not Southern California, Los Angeles. statistically significant. The results of the trial are reported in the However, after all patients had been fol Sept. 3 issue of the Annals of Internal lowed for at least 1 year after the end of the Medicine under the title Continuous or study, mortality rates were 11 .9 percent in Nocturnal Oxygen Therapy in Hypoxemic the continuous oxygen therapy group, and Chronic Obstructive Lung Diseases: A 20.6 percent in the nocturnal oxygen group. Clinical Trial. □ George McGuire (r), recently retired as chief of the Electrical Enginee ring Section, Engineering Design Branch, DES, is congratulated by Ro ss Holliday, director of the Division of Engineering Services. He received the NIH "ward of Me rit "for exemplary technical contributions in the administration of the electrical design program" at NIH . Smoking is responsible for more deaths Dr. Ruth L. Kirschstein, Director, NIGMS, one of the nine NIH "Meritorious Executives" who re every year than the American battlefield ceived a $10,000 bonus for outstanding work performance, is congratulated by Charles Miller, tolls in World War II. Deputy "ssistant Secretary for Health Operations. HHS Secretary Patricia Roberts Harris presented the awards in a recent ceremony at the Humphrey Bldg. L to rare: Secretary Harris, HHS Under Secretary Nathan Stark, Mr. Miller, and NIH Director Dr. Donald S. Fredrickson. December 9, 1980 The NIH Record Page 13 Biological Regulators of Metabolism Discussed At Recent Science Writers Seminar Visiting Scientist Program The elaborate communications system and chief of the Laboratory of Clinical In enabling cells to coordinate their wide vestigation, National Institute of Allergy and Participants range of biological activities was the subject Infectious Diseases, discussed the comple of a recent NIH science writers seminar. ment system, a series of serum proteins in Sponsored by Fogarty lnternat'I Center Three NIH scientists discussed their re volved in host defense and disease. search on several regulators of biological The 18-20 known components of com 11/16-Dr. Ana Szarfman, Argentina, laboratory processes. plement act in a precise sequence of care of Developmental Biology and Anomalies. Dr. Earl Stadtman, chief of the Laboratory Sponsor: Dr. George Martin, NIDR, Bg. 30, Rm. fully regulated steps to physically punch 416. of Biochemistry, National Heart, Lung, and holes in the surface of red or white blood 11/17-Dr. Toshihiko Kuroiwa, Japan, Labora Blood Institute, described the role of en cells as well as bacteria. These holes lead to tory of Neuropathology and Neu roanatomical zymes in converting "foods" into the com ultimate lysis- destruction-of the cell. Diseases. Sponsor: Dr. Igor Klatzo, NINCDS, plex molecules- nucleic acids, complex The complement cascade can be activated Bg. 36, Rm. 4004. lipids and carbohydrates, and prroteins in two ways. The classical pathway requires 11/18-Dr. Mario Barragan, Boliv ia, Laboratory necessary to maintain the body's.stability. the presence of antibody. But certain of Central Nervous System Studies. Sponsor: The regulation of many important structures like bacterial surfaces, appear to Dr. Clarence Gibbs, NINCDS, Bg. 36, Rm. 4A17. b iochemical processes involves activation act with another series of protein compo 11/18- Dr. Dilip S. Shah, India, laboratory of or inactivation of key enzymes by coval ent nents to activate the cascade via an alter Preclinical Pharmacology. Sponsor: Dr. Ales sand ro Guidotti, N IMH, St. El izabeths Hospital. modification reactions-ones involving the nate pathway. This pathway then joins the 11/19-Dr. H. Ian Keizer, Netherlands, attachment of certain chemical groups such classical seq uence at the level of the third Medicine Branch. Sponsor: Dr. Robert Ozols, as phosphoryl or nucleotidyl groups to the component of complement. NCI, Bg. 10, Rm. 12N226. enzyme. When an infection is introduced and 11 /20-Dr. Joseph Kaminchik, Israel, laboratory antibody is present, the classical pathway is of Tumor Virus Genetics. Sponsor: Dr. Edward Cascade Systems Described rapidly recruited to the body's defense. Scolnick, NCI, Bg. 41, Rm. A114. Because these modifications and demod However, when a bacterium is encountered 11 /21-D r. Choong San Oh, Korea, laboratory ification reactions are catalyzed by so-cal led for the first time and therefore no antibody of Oral Medicine. Sponsor: Dr. Ji -Won Yoon, converter enzymes, they involve the action NIDR, Bg. 30, Rm. 232. is present, complement can be activated via 11/21-Dr. Pieter Sonneveld, Netherlands, of one enzyme upon another and are the alternate pathway to ward off the infec Clinical Oncology Program. Sponsor: Dr. therefore referred to as cascade systems. tion. Charles Myers, NCI, Bg. 10, Rm . 6N104. Research by Dr. Stadtman and others has Compl ement proteins are also responsi shown that such cascades are endowed with ble for producing many features of the in extraordinary characteristics making them flammatory response. Fragments of com that the drug, danazol, can correct an in uniquely effective for regulating key en plement components can produce hives, herited deficiency in the activity of a pro· zymatic processes. For example, they serve dilate blood vessels, and generate tein which inhibits the first component of as multiplier systems that are capable of chemotactic factors. complement. This abnormality is believed generating an amplified response to pri The role of complement in the produc to be the cause of hereditary angioedema. mary stimuli within milliseconds. tion of human disease is usually the resu lt Continuous use of danazol by HAE pa Recent studies suggest that cyclic cas of the proteins being activated under inap tients has been found to prevent the cades may play an even greater role in cel propriate circumsta nces. An individual with characteristic episodes of swelling of the lular regulation than previously thought. circulating antigen-antibody compl exes may extremities, gastrointestinal tract, face and Current evidence indicates that covalent have these complexes deposited in the kid neck. Involvement of the latter can be enzyme modification is the basis for a com ney where they activate complement and life-threatening if the airway is blocked. plex network of interlocking cascades ca use tissue damage. At present, there is no Calmodulin, another protein which which respond to biological signals, and drug avai lable to regulate the complement mediates the control of a large number of thereby permit a coordinated and syn system in man. enzymes by the binding of calcium ions, chronous control for many biochemical A few years ago, Dr. Frank and other in was then reviewed for the science writers functions. tramural scientists-Ors. Jeffrey Gelfand, by Dr. Claude Klee. She is chief of the Dr. M ichael M. Frank, clinical director David Alling, and Ri chard Sherins- found Macromolecular Interactions Section of the National Cancer lnstitute's Laboratory of Biochemistry. Work in numerous laboratories has shown that calmodulin may be a universal receptor of calcium when acting as a second messenger. The protein regulates not only cyclic nucleotide metabolism but also helps regulate cell motility. Calmodulin regulates metabolic pathways and activates the calcium ion pump of the red blood cell membrane. Recent research has shown that the protein may be impor tant in modulating the synthesis, release, and action of neurotransmitters at the synaptic levels. Dr. Klee discussed research by her and others on the mechanism of calmodulin ac tivation o f enzyme activity. She thinks i t may soon become more interesting to ask Awards for outstanding performance at the lnternation.il Visitors Center were recently presented to (I to r): Mary E. Low, JoAnn Boley, Ella Menser, .ind Marian Beratan. This Fogarty lntern.itional which cellular processes are not under cal Center office h.is administrative responsibility for the NIH Visiting Program, which had 1,000 par• modulin control than those which are, since 1icipants in FY 1980. Also, the staff ilssisted 400 guest workers and other foreign scientists at NIH on it is apparent that a large part of cellular a long-term basis. Their resourcefulness and versatility in dealing with questions ranging from in metabolism and function is under the direct come tax and visa regul.itions to tr.ave[, housing, and health insur.ince have kept papers moving or indirect control of this small but pre• smoothly despite a continuing st.iff shortage and increasing number of foreign scientists. cisely designed protein. D Page 14 The NIH Record December 9, 1980 Cynthia A. Hall, NIEHS, Wins Certificate of Excellence Nuclear Medicine Research Award Shared i By Ors. Otteson and Hussain Ors. Eric Otteson and Rabia Hussain of the National Institute of Allergy and Infecti ous Diseases' Laboratory of Parasitic Dis eases, and Ors. Robert G. Hamilton and Franklin N. Adkinson, Jr., of Johns Hopkins University School of Medicine are the 1980 co-winners of the Society of Nuclear Medicine's Berson-Yalow Award i n recogni tion of "excellence in basic radioassay re search." The award, which was presented to the group at the recent meeting by the Society of Nuclear Medicine's Education and Re search Foundation, consists of a plaque and a $750 honorarium. Winners of this year's award were recog nized as the first group to use solid phase radioimmunoassay to measure lgG and lgE antibodies to antigens of the parasite re sponsible for filariasis, a d isease endemic in J the tropics, and one of six tropical diseases Dr. G.iMn .ind Ms. Hall resurch the biological effects of microwaves on reproduction in the NIEHS earmarked by the World Health Organiza labor.itory of Environmental Biophysics. tion for increased research and trai ning. The Berson-Yalow Award was established Research relating to the biological effects measured in milliwatts per gram. Before and by the Society of Nuclear Medici ne in 1977, of microwaves on reproduction won a cer after irradiation, the ability of the sperm to and has since been presented at the Soci tificate of excellence for Cynthia A. Hall, a fertilize an egg was tested. ety's annual meeting. The award honors the technician in the Laboratory of Environ The investigation showed that the 96 per late Drs. Solomon A. Berson, and Rosalie mental Biophysics at the National Institute cent viability of the sperm was not affected Sussman Yalow, a 1977 Nobel Prize of Environmental Health Sciences. at any of the exposure levels examined, and winner-both are pioneers in the field of Ms. Hall, a candidate for a master of that other characteristics of the samples in rad ioi mm unoassays. science degree in the department of poultry releasing enzymes were likewise unchanged Dr. Hamilton has recently left Johns Hop science at North Carolina State University, by microwave irradiation. kins to join the staff of the VA Medical recently received the award at the 69th an "Thus," the research abstract concludes, Center in Bronx, N.Y. □ nual meeting of the Poultry Science Associ "microwave radiation appeared to have no ation at Purdue University. adverse effects on the parameters measured Her research is part of her degree pro for mature sperm irradiated in vitro." gram and was done in collaboration with Only 12 of the 123 graduate student pa Drs. Donald I. McRee, leader of the pers read at the meeting of the Poultry Sci nonionizing radiation workgroup, and ence Association were honored with a cer Michael J. Galvin, also of the workgroup, tificate of excellence. within the Laboratory of Environmental A resident of Conover, N.C., Ms. Hall Biophysics. graduated with distinction in 1979 from In this research, sperm obtained from Duke University in chemistry. She plans to turkeys was exposed to microwaves at a attend medical school but does not rule o ut specific frequency, for a set length of time a future in environmental health re- (30 minutes), and at three different levels search. □ DR. DEVITA New 'Human Genetic Mutant (Continued from Page 1) Cell Repository' Catalog Issued MOPP therapy attain complete remission, Two staff members were honored for their work and appear to be cured. The Human Genetic Mutant Cell Reposit al a recent meeting of the NLM Board of Direc• Dr. De Vita has also proposed other drug ory catalog, listing 4,200 human genetic tors. Mary E. Corning, assistant director for In• combinations that have led to advances in mutant cell lines, has been published by the ternational Programs, received the 1980 Re the treatment of non-Hodgkin's lymphoma National Institute of General Medical Sci gents' Award for Scholarly or Technical and breast and ovarian cancers. ences and is available to investigators. Achievement, for her book, "A Review of the After the p resentation ceremonies, Dr. This seventh edition of the catalog has United States Role in International Biomedical DeVita gave an award lecture on progress in approximately 300 new cell lines. Research and Communication: International cancer chemotherapy. All cultures in the collection are stored in Health and Foreign Policy. " Dr. loseph Leiter, Previous award recipients have included associate director for library Operations, wa s liquid nitrogen, including human fibroblast, presented the 1980 NLM Director's Award, for scientists from Sweden, the United King lymphoblast, and amniotic fluid cell cul leading a special MEDLARS Ill task force that dom, France, and the United States. Recip tures as well as virus transformed fibroblast developed plans lo automate NLM's activiiies ients are chosen by a 10-member committee cultures and selected animal cell lines. during the coming decade. of ADRC oncologists. ln addi tion to the mutant cell lines, the The prize was first given in 1970, and the catalog has a listing of cells relevant to monetary award is derived from the yearly aging. This portion is supported by the ports, Westwood Bldg., Rm. 9A-10, 496- revenues obtained from the buildings in National Institute on Aging. 7301, or the Institute of Medical Research , Paris owned by the late Leopold Griffuel, a Copies of the catalog may be obtained Copewood and Davis Streets, Camden, N.J. French attorney and philanthropist. □ from the NIGMS Office of Research Re- 08103. 0 December 9, 1980 The NIH Record Page 15 lnternat'I Workshop Focuses on Concepts Dr. Leroy Hood To Deliver Of Regulating Protein Synthesis Kinyoun Lecture Dec. 19 Dr. Leroy E. Hood will deliver the Experts from around the world will meet investigato rs will present summaries of Kinyoun Lecture, sponsored by the National in Bethesda Jan. 18-20 for a workshop their respective research areas. Later ses Institute of Allergy and Infectious Diseases, focusing on current concepts regarding the sions will promote the fullest possible in ,on Friday, Dec. 19, at 4 p.m. in Bldg. 1, regu lation of protein synthesis within cells. terchange between the two groups in order Wilson Harl. The 2½-day meeting on the Role of Co to stimulate research progress. He will speak on valent Modification in the Control of Pro The workshop will have 31 invited speak Antibody Genes tein Synthesis will be cosponsored by the ers and discussants, an additional 80 invited and Strategies for National Institute of General Medical Sci participants, and ample seating for obser Their Expression. ences, the National Cancer Institute, the vers. Dr. Hood is National Institute of Arthritis, Metabolism, presently Bowles and Digestive Di seases, the National Heart, It will be held in the auditorium of the Uniformed Services University of the Health Professor of Biol Lung, and Blood Institute, and the Interna ogy and chairman, tional Union of Biochemistry. Sciences (4301 Jones Bridge Road, Bethesda). division of biology, The workshop will bring together spe at the California cialists in the regulatory mechanisms of Program details and directions for parking Institute of Tech protein synthesis and investigators who will be announced later. Meanwhile, addi nology. have specialized in covalent regulatory tional information about the workshop can Or. Hood His research mechanisms controlling other cellular proc be obtained by calling either Dr. Brian intere~ts are in the esses. Safer, (301) 496-1284 or Dr. Barbara R. organization, expression, and evolution of At the first two sessions, each group of Williams, NIGMS, (301) 496-7087. D antibody genes. A central question in all of his studies concerns the nature of genetic mechanisms for generating antibody diver sity. The Kinyoun Lecture series honors Dr. Joseph J. Kinyoun, who e~tablished the Laboratory of Hygiene at the Marine Hos p ital on Staten Island that evolved into NIH. □ Youth Motivation Program Led by Dr. Malone N IH Deputy Director Dr. Thomas E. Malone served as co-leader for the Youth Motivation Program held recently at the North Carolina Central University in Durham. The program is a joint venture of the Na tional Alliance of Businessmen, the Presi dent's Task Force on Youth Motivation, and selected academic institutions. It is de signed to expand the occupational outlook of students in traditionally black colleges. Dr. Malone, with Dr. Mable P. Phifer, president of the Robert R. Morton Institute of Gloucester, Va., led a team of 175 that Dr. Kretchmer (seated r o n the sofa) sits next to Prof. Bozkowa and joins other members of the included a wide spectrum of the nation' s Polish health d elegation at Stone House. industrial, financial, and publishing enter prises as well as country, State, and Federal A group of six men and women from Po the meeting was to continue the informa agencies. land, all physicians or professors o f tion exchange between the investigators in The team members met in small groups medicine specializing in problems of chil pediatrics at the NIH and the Polish insti with the students over a 2-day period to dren, recently visited NIH during the Fifth tutes. counsel and encourage them in their career interests. □ U.S.-Polish Medical Week. At NIH, scientific sessions were held, The event, coordinated by the National consisting of clinical grand rounds given by Institute of Child Health and Human De Professor Bozkowa on a screening program Mider Lecture To Be Held Tomorrow velopment, was held in accordance with the in Poland for inborn errors of metabolism, 1974 Intergovernmental Agreement on and a 2-day seminar at the Stone House, Dr. Louis Sokoloff, chief of the Nati onal Cooperation in the Field of Heal th between spo nsored by NICHD w ith the cooperation Institute of Mental Health's Laboratory of the United States and the Polish People's of the Fogarty International Center and the Cerebral Metabolism and devel oper of the Republic. D.C. ChaptE:~ 0f the American Academy of radioactive deoxyglucose method of Continue to Exchange Data Ped iatrics . measuring functional brain activity, will The medica l week, co-chaired by Dr. Following the observance of U.S.-Polish present the G. Burroughs Mider Lecture Norman Kretchmer, NICHD Director, and Medical Week, Dr. Kretchmer and Professor tomorrow (Dec. 10), at 8:15 p.m., in the Prof. Krystyna Bozkowa, leader of the Polish Bozkowa signed an agreement to continue Masur Audito rium . □ delegation, had as its subject research in the exchange of information on maternal maternal and child health. Professor Boz and child health and to identify common kowa is director of the National Institute of research interests and areas in need of fur Mother and Child, Warsaw . The purpose of ther exploration. □ * U.S. GOVERNMENT PRINTING OFFICE: 19BU- 311-203/107 Page 16 The NIH Record December 9, 1980