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RANDY SCHEKMAN Department of Molecular and Cell Biology, Howard Hughes Medical Institute, University of California, Berkeley, USA
GENES AND PROTEINS THAT CONTROL THE SECRETORY PATHWAY Nobel Lecture, 7 December 2013 by RANDY SCHEKMAN Department of Molecular and Cell Biology, Howard Hughes Medical Institute, University of California, Berkeley, USA. Introduction George Palade shared the 1974 Nobel Prize with Albert Claude and Christian de Duve for their pioneering work in the characterization of organelles interrelated by the process of secretion in mammalian cells and tissues. These three scholars established the modern field of cell biology and the tools of cell fractionation and thin section transmission electron microscopy. It was Palade’s genius in particular that revealed the organization of the secretory pathway. He discovered the ribosome and showed that it was poised on the surface of the endoplasmic reticulum (ER) where it engaged in the vectorial translocation of newly synthesized secretory polypeptides (1). And in a most elegant and technically challenging investigation, his group employed radioactive amino acids in a pulse-chase regimen to show by autoradiograpic exposure of thin sections on a photographic emulsion that secretory proteins progress in sequence from the ER through the Golgi apparatus into secretory granules, which then discharge their cargo by membrane fusion at the cell surface (1). He documented the role of vesicles as carriers of cargo between compartments and he formulated the hypothesis that membranes template their own production rather than form by a process of de novo biogenesis (1). As a university student I was ignorant of the important developments in cell biology; however, I learned of Palade’s work during my first year of graduate school in the Stanford biochemistry department. -
Unrestricted Immigration and the Foreign Dominance Of
Unrestricted Immigration and the Foreign Dominance of United States Nobel Prize Winners in Science: Irrefutable Data and Exemplary Family Narratives—Backup Data and Information Andrew A. Beveridge, Queens and Graduate Center CUNY and Social Explorer, Inc. Lynn Caporale, Strategic Scientific Advisor and Author The following slides were presented at the recent meeting of the American Association for the Advancement of Science. This project and paper is an outgrowth of that session, and will combine qualitative data on Nobel Prize Winners family histories along with analyses of the pattern of Nobel Winners. The first set of slides show some of the patterns so far found, and will be augmented for the formal paper. The second set of slides shows some examples of the Nobel families. The authors a developing a systematic data base of Nobel Winners (mainly US), their careers and their family histories. This turned out to be much more challenging than expected, since many winners do not emphasize their family origins in their own biographies or autobiographies or other commentary. Dr. Caporale has reached out to some laureates or their families to elicit that information. We plan to systematically compare the laureates to the population in the US at large, including immigrants and non‐immigrants at various periods. Outline of Presentation • A preliminary examination of the 609 Nobel Prize Winners, 291 of whom were at an American Institution when they received the Nobel in physics, chemistry or physiology and medicine • Will look at patterns of -
Fotonica Ed Elettronica Quantistica
Fotonica ed elettronica quantistica http://www.dsf.unica.it/~fotonica/teaching/fotonica.html Fotonica ed elettronica quantistica Quantum optics - Quantization of electromagnetic field - Statistics of light, photon counting and noise; - HBT and correlation; g1 e g2 coherence; antibunching; single photons - Squeezing - Quantum cryptography - Quantum computer, entanglement and teleportation Light-matter Interaction - Two-level atom - Laser physics - Spectroscopy - Electronics and photonics at the nanometer scale - Cold atoms - Photodetectors - Solar cells http://www.dsf.unica.it/~fotonica/teaching/fotonica.html Energy Temperature LHC at CERN, Higgs, SUSY, ??? TeV 15 q q particle accelerators 10 K q GeV proton rest mass - quarks 1012K MeV electron rest mass / gamma rays 109K keV Nuclear Fusion, x rays, Sun center 106K Atoms ionize - visible light eV Sun surface fundamental components components fundamental room temperature 103K meV Liquid He, superconductors, space 1K dilution refrigerators, quantum Hall µeV laser-cooled atoms 10-3K neV Bose-Einstein condensates 10-6K peV low T record 480 picokelvin 10-9K -12 complexity, organization organization complexity, 10 K Nobel Prizes in Physics 2010 - Andre Geims, Konstantin Novoselov 2009 - Charles K. Kao, Willard S. Boyle, George E. Smith 2007 - Albert Fert, Peter Gruenberg 2005 - Roy J. Glauber, John L. Hall, Theodor W. Hänsch 2001 - Eric A. Cornell, Wolfgang Ketterle, Carl E. Wieman 1997 - Steven Chu, Claude Cohen-Tannoudji, William D. Phillips 1989 - Norman F. Ramsey, Hans G. Dehmelt, Wolfgang Paul 1981 - Nicolaas Bloembergen, Arthur L. Schawlow, Kai M. Siegbahn 1966 - Alfred Kastler 1964 - Charles H. Townes, Nicolay G. Basov, Aleksandr M. Prokhorov 1944 - Isidor Isaac Rabi 1930 - Venkata Raman 1921 - Albert Einstein 1907 - Albert A. -
Quid Est 'Bioethics'?
What Is “Bioethics”? (Quid est ‘Bioethics’?) Dianne N. Irving “A small error in the beginning leads to a multitude of errors in the end.” Thomas Aquinas, De Ente Et Essentia Aristotle, De Coelo I. INTRODUCTION There is a strange phenomenon I have encountered over the last several years which I hope at least to identify with this essay. It is the apparent belief that bioethics is somehow the same as, or to be equated with, ethics per se, or at least with medical ethics per se. I have even heard it referred to as Roman Catholic medical ethics per se. Repeatedly, when I ask a group to define “bioethics,” I usually get the same sort of response. I hope with this essay to disenfranchise people of this belief. Contrary to “popular opinion,” bioethics, as predominantly practiced today–especially as embedded in formal governmental regulations, state laws and a myriad of other documents, committees, guidelines, guidebooks, etc., around the worldi–is not the same thing as “ethics per se.” Academically it is actually a sub-field of ethics and stands alongside many other theories of ethics, e.g., Kantian deontology, Millsean utilitarianism, casuistry, natural law, egoism, situation ethics, relativism, and various forms of theological ethics, etc. And like all ethical theories, bioethics is by no means “neutral”–there is no such thing as a “neutral ethics.”ii In fact, bioethics defines itself as a normative ethical theory–that is, it takes a stand on what is right or wrong.iii Nor is bioethics to be equated with “medical ethics,” as that term is still generally understood.iv Nor is it the same as Roman Catholic medical ethics or any other such subsystem of ethics that could be used to determine the rightness and wrongness of human actions within the 1 medical context. -
Geoffrey Wilkinson
THE LONG SEARCH FOR STABLE TRANSITION METAL ALKYLS Nobel Lecture, December 11, 1973 by G EOFFREY W ILKINSON Imperial College of Science & Technology, London, England Chemical compounds in which there is a single bond between a saturated car- bon atom and a transition metal atom are of unusual importance. Quite aside from the significance and role in Nature of the cobalt to carbon bonds in the vitamin B 12 system and possible metal to carbon bonds in other biological systems, we need only consider that during the time taken to deliver this lec- ture, many thousands, if not tens of thousands of tons of chemical compounds are being transformed or synthesised industrially in processes which at some stage involve a transition metal to carbon bond. The nonchemist will pro- bably be most familiar with polyethylene or polypropylene in the form of do- mestic utensils, packaging materials, children’s toys and so on. These materials are made by Ziegler-Natta* or Philipps’ catalysis using titanium and chro- mium respectively. However, transition metal compounds are used as catalysts in the synthesis of synthetic rubbers and other polymers, and of a variety of simple compounds used as industrial solvents or intermediates. For example alcohols are made from olefins, carbon monoxide and hydrogen by use of cobalt or rhodium catalysts, acetic acid is made by carbonylation of methanol using rhodium catalysts and acrylonitrile is dimerised to adiponitrile (for nylon) by nickel catalysts. We should also not forget that the huge quantities of petroleum hydrocarbons processed by the oil and petrochemical industry are re-formed over platinum, platinum-rhenium or platinum-germanium sup- ported on alumina. -
Computing ATOMIC NUCLEI
UNIVERSAL NUCLEAR ENERGY DENSITY FUNCTIONAL Computing ATOMIC NUCLEI Petascale computing helps disentangle the nuclear puzzle. The goal of the Universal Nuclear Energy Density Functional (UNEDF) collaboration is to provide a comprehensive description of all nuclei and their reactions based on the most accurate knowledge of the nuclear interaction, the most reliable theoretical approaches, and the massive use of computer power. Science of Nuclei the Hamiltonian matrix. Coupled cluster (CC) Nuclei comprise 99.9% of all baryonic matter in techniques, which were formulated by nuclear sci- the Universe and are the fuel that burns in stars. entists in the 1950s, are essential techniques in The rather complex nature of the nuclear forces chemistry today and have recently been resurgent among protons and neutrons generates a broad in nuclear structure. Quantum Monte Carlo tech- range and diversity in the nuclear phenomena that niques dominate studies of phase transitions in can be observed. As shown during the last decade, spin systems and nuclei. These methods are used developing a comprehensive description of all to understand both the nuclear and electronic nuclei and their reactions requires theoretical and equations of state in condensed systems, and they experimental investigations of rare isotopes with are used to investigate the excitation spectra in unusual neutron-to-proton ratios. These nuclei nuclei, atoms, and molecules. are labeled exotic, or rare, because they are not When applied to systems with many active par- typically found on Earth. They are difficult to pro- ticles, ab initio and configuration interaction duce experimentally because they usually have methods present computational challenges as the extremely short lifetimes. -
R. Stephen Berry 1931–2020
R. Stephen Berry 1931–2020 A Biographical Memoir by Stuart A. Rice and Joshua Jortner ©2021 National Academy of Sciences. Any opinions expressed in this memoir are those of the authors and do not necessarily reflect the views of the National Academy of Sciences. RICHARD STEPHEN BERRY April 9, 1931–July 26, 2020 Elected to the NAS, 1980 We have prepared this memoir to bear witness to the life of R. Stephen (Steve) Berry, with emphasis on the view that a memorial is about reminding ourselves and others of more than his many and varied contributions to science; it is also to remind us of his personal warmth and freely offered friendship, of his generous support for all of us in a variety of situations, and of his loyalty to his friends and the institutions he served. The record of an individ- ual’s accomplishment is commonly taken to define his/ her legacy. Using that protocol, creative scientists are fortunate in that their contributions are visible, and those contributions endure, or not, on their own merits. Steve Berry was one of the most broadly ranging and influen- tial scientists in the world. His seminal experimental and By Stuart A. Rice theoretical contributions are distinguished by a keen eye and Joshua Jortner for new concepts and innovative and practical analyses. These contributions, which are remarkable in both scope and significance, have helped to shape our scientific perception. They have had, and continue to have, great influence on the development of chemistry, biophysics materials science, the science and technology related to the use, production, and conservation of energy, the societal applications of science and technology, and national and international science policy. -
Medicine After the Holocaust
Medicine after the Holocaust Previously published by Sheldon Rubenfeld: Could It Be My Thyroid? Medicine after the Holocaust From the Master Race to the Human Genome and Beyond Edited by Sheldon Rubenfeld In Conjunction with the Holocaust Museum Houston medicine after the holocaust Copyright © Sheldon Rubenfeld, 2010 Softcover reprint of the hardcover 1st edition 2010 978-0-230-61894-7 All rights reserved. First published in 2010 by PALGRAVE MACMILLAN® in the United States - a division of St. Martin’s Press LLC, 175 Fifth Avenue, New York, NY 10010. Where this book is distributed in the UK, Europe and the rest of the World, this is by Palgrave Macmillan, a division of Macmillan Publishers Limited, registered in England, company number 785998, of Houndmills, Basingstoke, Hampshire RG21 6XS. Palgrave Macmillan is the global academic imprint of the above companies and has companies and representatives throughout the world. Palgrave® and Macmillan® are registered trademarks in the United States, the United Kingdom, Europe and other countries. ISBN: 978–0–230–62192–3 (paperback) ISBN 978-0-230-62192-3 ISBN 978-0-230-10229-3 (eBook) DOI 10.1057/9780230102293 Library of Congress Cataloging-in-Publication Data is available from the Library of Congress. Design by Integra Software Services First edition: January 2010 10987654321 Permissions Portions of Chapter 7, “Genetic and Eugenics,” are from A Passion for DNA: Genes, Genomes and Society, pp. 3–5, 179–208, 209–222, by James D. Watson, Cold Spring Harbor Laboratory Press 2000. c James. D. Watson. Reprinted with permission of James D. Watson. Chapter 5, “Mad, Bad, or Evil: How Physicians Healers Turn to Torture and Murder” was discussed and published in “Physicians and Torture: Lessons from the Nazi Doc- tors,” by Michael A. -
Chemistry News
Fall 2015 Chemistry News Filling the Chemical Sciences Pipeline Future chemists are being recruited by the Department of Chemistry at every age from grade school children to postdoctoral scholars. Hands-on activities encourage girls to learn and explore their potential in science, technology, math and engineering. FEMMES, a UM student organization, organizes events for 4th-6th grade girls on campus and in afterschool programs. Chemistry faculty organized lab tours for students students newly admitted to the University of Michigan in the Summer Bridge program. afety glasses and gloves in place, Johana and a dozen other fourth grade Sgirls used pipettes to drip a creamy mixture into cups of liquid nitrogen, watching the drops freeze instantly into an ice cream treat. After the graduate students strained the tasty dots out of the cup, the girls were able to eat the Cass Technical High School students spent the summer doing result of their experiment. research as part of the UM Detroit Research Internship These girls were attending an all-day event at the UM Chemistry build- Summer Experience, D-RISE. They participated alongside the ing organized by FEMMES, Females Excelling More in Math, Engineering, UM graduate students in the Karle Symposium. and the Sciences. FEMMES aims to inspire young girls, encouraging them to consider their potential in science and math. Each event features hands-on activities led by volunteers. Chemistry’s undergraduates, graduate students, and faculty are very active in the Michigan chapter of FEMMES. On a recent Saturday, FEMMES brought 300 girls to campus from Detroit and area schools to participate in twenty different activities. -
The Physical Tourist Physics and New York City
Phys. perspect. 5 (2003) 87–121 © Birkha¨user Verlag, Basel, 2003 1422–6944/05/010087–35 The Physical Tourist Physics and New York City Benjamin Bederson* I discuss the contributions of physicists who have lived and worked in New York City within the context of the high schools, colleges, universities, and other institutions with which they were and are associated. I close with a walking tour of major sites of interest in Manhattan. Key words: Thomas A. Edison; Nikola Tesla; Michael I. Pupin; Hall of Fame for GreatAmericans;AlbertEinstein;OttoStern;HenryGoldman;J.RobertOppenheimer; Richard P. Feynman; Julian Schwinger; Isidor I. Rabi; Bronx High School of Science; StuyvesantHighSchool;TownsendHarrisHighSchool;NewYorkAcademyofSciences; Andrei Sakharov; Fordham University; Victor F. Hess; Cooper Union; Peter Cooper; City University of New York; City College; Brooklyn College; Melba Phillips; Hunter College; Rosalyn Yalow; Queens College; Lehman College; New York University; Courant Institute of Mathematical Sciences; Samuel F.B. Morse; John W. Draper; Columbia University; Polytechnic University; Manhattan Project; American Museum of Natural History; Rockefeller University; New York Public Library. Introduction When I was approached by the editors of Physics in Perspecti6e to prepare an article on New York City for The Physical Tourist section, I was happy to do so. I have been a New Yorker all my life, except for short-term stays elsewhere on sabbatical leaves and other visits. My professional life developed in New York, and I married and raised my family in New York and its environs. Accordingly, writing such an article seemed a natural thing to do. About halfway through its preparation, however, the attack on the World Trade Center took place. -
Of Charles D. Ferguson, on Behalf Of
FEDERATION OF AMERICAN SCIENTISTS T: 202/546-3300 1725 DeSales Street, NW 6th Floor Washington, DC 20036 www.fas.org F: 202/675-1010 [email protected] PRM-70-9 DOCKETED Board of Sponsors (75FR80730) USNRC (PartialList) March 4, 2011 March 7, 2011 (10:30 am) •Pacr Agre * SidnheyAman * Philip W. Anderson *Kenneth J. Arrow To: Secretary, U.S. Nuclear Regulatory Commission OFFICE OF SECRETARY * David Baltimore RULEMAKINGS AND * Bamj Be.....ea Washington, DC 20555-0001 SPaulBerg ADJUDICATIONS STAFF * J. Michael Bishop AT-TN: Rulemakings and Adjudications Staff * Guther Blobel * Nicolaas Bloensbergen * Paul Boyce Ann Pitts Carter Subject: Comment on Docket ID NRC-2010-0372, "Petition for Rulemaking, * Stanley Cohen * Leon N. Cooper Francis Slakey on Behalf of the American Physical Society" * E. J. Corey 'James Cronin * Johann Deismehofer ArmDruyan *RenatoDulbeomo As Board Members of the Federation of American Scientists, an independent, Paul L Ehrlich George Field nonpartisan think tank, we strongly support the petition submitted by the Vat L. Fitch * JeromeI. Friedman American Physical Society that requests proliferation risk assessments become a * Riccardo Giacoani * Walter Gilbert required part of the NRC licensing process. * Alfed G. Gilman " Donald Glaser * Sheldon L. Glashow Marvin L. Goidhergr * Joseph L. Goldstein Emerging nuclear fuel technologies such as laser enrichment of uranium can pose Roger C. L. Gaillemin * L[land H. Hartwell significant proliferation risks due to difficulties in detecting facilities using these * Herbert A. Hauptman " Dudley RKHIaechach technologies. If such technologies are developed without a clear, objective, and * Roald Hoff-aan John P. Hoidren detailed assessment, they can dangerously undermine U.S. nuclear * -l Robert Horvitz * David H. -
A Short History of DNA Technology 1865 - Gregor Mendel the Father of Genetics
A Short History of DNA Technology 1865 - Gregor Mendel The Father of Genetics The Augustinian monastery in old Brno, Moravia 1865 - Gregor Mendel • Law of Segregation • Law of Independent Assortment • Law of Dominance 1865 1915 - T.H. Morgan Genetics of Drosophila • Short generation time • Easy to maintain • Only 4 pairs of chromosomes 1865 1915 - T.H. Morgan •Genes located on chromosomes •Sex-linked inheritance wild type mutant •Gene linkage 0 •Recombination long aristae short aristae •Genetic mapping gray black body 48.5 body (cross-over maps) 57.5 red eyes cinnabar eyes 67.0 normal wings vestigial wings 104.5 red eyes brown eyes 1865 1928 - Frederick Griffith “Rough” colonies “Smooth” colonies Transformation of Streptococcus pneumoniae Living Living Heat killed Heat killed S cells mixed S cells R cells S cells with living R cells capsule Living S cells in blood Bacterial sample from dead mouse Strain Injection Results 1865 Beadle & Tatum - 1941 One Gene - One Enzyme Hypothesis Neurospora crassa Ascus Ascospores placed X-rays Fruiting on complete body medium All grow Minimal + amino acids No growth Minimal Minimal + vitamins in mutants Fragments placed on minimal medium Minimal plus: Mutant deficient in enzyme that synthesizes arginine Cys Glu Arg Lys His 1865 Beadle & Tatum - 1941 Gene A Gene B Gene C Minimal Medium + Citruline + Arginine + Ornithine Wild type PrecursorEnz A OrnithineEnz B CitrulineEnz C Arginine Metabolic block Class I Precursor OrnithineEnz B CitrulineEnz C Arginine Mutants Class II Mutants PrecursorEnz A Ornithine