1 Senate Commerce Committee Nominee Questionnaire Eric Steven
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RANDY SCHEKMAN Department of Molecular and Cell Biology, Howard Hughes Medical Institute, University of California, Berkeley, USA
GENES AND PROTEINS THAT CONTROL THE SECRETORY PATHWAY Nobel Lecture, 7 December 2013 by RANDY SCHEKMAN Department of Molecular and Cell Biology, Howard Hughes Medical Institute, University of California, Berkeley, USA. Introduction George Palade shared the 1974 Nobel Prize with Albert Claude and Christian de Duve for their pioneering work in the characterization of organelles interrelated by the process of secretion in mammalian cells and tissues. These three scholars established the modern field of cell biology and the tools of cell fractionation and thin section transmission electron microscopy. It was Palade’s genius in particular that revealed the organization of the secretory pathway. He discovered the ribosome and showed that it was poised on the surface of the endoplasmic reticulum (ER) where it engaged in the vectorial translocation of newly synthesized secretory polypeptides (1). And in a most elegant and technically challenging investigation, his group employed radioactive amino acids in a pulse-chase regimen to show by autoradiograpic exposure of thin sections on a photographic emulsion that secretory proteins progress in sequence from the ER through the Golgi apparatus into secretory granules, which then discharge their cargo by membrane fusion at the cell surface (1). He documented the role of vesicles as carriers of cargo between compartments and he formulated the hypothesis that membranes template their own production rather than form by a process of de novo biogenesis (1). As a university student I was ignorant of the important developments in cell biology; however, I learned of Palade’s work during my first year of graduate school in the Stanford biochemistry department. -
Delegate List
About CTBUH The Council on Tall Buildings and Urban Habitat (CTBUH) is the world’s leading resource for professionals focused on the inception, design, construction, and operation of tall buildings and future cities. Founded in 1969 and headquartered at Chicago’s historic Monroe Building, the CTBUH is a not-for-profit organization with an Asia Headquarters office at Tongji University, Shanghai; a Research Office at Iuav University, Venice, Italy; and an Academic Office at the Illinois Institute of Technology, Chicago. CTBUH facilitates the exchange of the latest knowledge available on tall buildings around the world through publications, research, events, working groups, web resources, and its extensive network of international representatives. The Council’s research department is spearheading the investigation of the next generation of tall buildings by aiding original Dubai & Abu Dhabi, UAE | 20–25 October research on sustainability and key development issues. The Council’s free database on tall buildings, The Skyscraper Center, is updated daily with detailed information, images, data, and news. The CTBUH also developed the international standards for measuring tall building height and is recognized as the arbiter for bestowing such designations as “The World’s Tallest Building.” Delegate List www.ctbuh.org | www.skyscrapercenter.com ctbuh2018.org #CTBUH2018 CTBUH2018_DelegateList_Cover.indd 2-3 10/12/2018 4:40:55 PM Many Thanks to All of Our Sponsors Delegate List: What’s Inside? Diamond Attendance Analysis 3 Top Regions & Companies Represented Delegate List by Company 6 Listed Alphabetically by Affi liation Platinum Delegate List by Surname 26 Listed Alphabetically by Surname Gold 1300+ DELEGATES 278 PRESENTERS 27 OFF-SITE WME consultants PROGRAMS 8 TRACKS Silver 4 1 EVENINGS OF GREAT RECEPTIONS SYMPOSIUMS 3 CONFERENCE! PROGRAM ROOMS 5 SPONSORS 68 128 CITIES 447 COMPANIES Bronze Supported By: COUNTRIES 54 2 Representation by Region Note: This registration list includes the 1240 delegates that were registered by Monday 8 October. -
Spring 2021 Bulletin
Advancing Access to Civil Justice STEPS TOWARD INTERNATIONAL CLIMATE GOVERNANCE Featuring William Nordhaus, Pinelopi Goldberg, and Scott Barrett HONORING WILLIAM LABOV, RUTH LEHMANN , AND GERTRUD SCHÜPBACH SPRING 2021 SELECT UPCOMING VIRTUAL EVENTS May 6 A Conversation with Architect 27 Reflections on a Full, Consequential, Jeanne Gang and Lucky Life: Science, Leadership, Featuring: Jeanne Gang and Education Featuring: Walter E. Massey (left) in conversation with Don Randel (right) June 14 Lessons Learned from Reckoning with Organizational History Featuring: John J. DeGioia, Brent Leggs, Susan Goldberg, Claudia Rankine, and Ben Vinson 13 Finding a Shared Narrative Hosted by the Library of Congress Featuring: Danielle Allen, winner of the Library’s 2020 Kluge Prize Above: “Our Common Purpose” featuring the Juneteenth flag with one star. Artist: Rodrigo Corral For a full and up-to-date listing of upcoming events, please visit amacad.org/events. SPRING 2021 CONTENTS Flooding beside the Russian River on Westside Road in Healdsburg, Sonoma County, California; February 27, 2019. Features 16 Steps Toward International 38 Honoring Ruth Lehmann and Gertrud Climate Governance Schüpbach with the Francis Amory Prize William Nordhaus, Pinelopi Goldberg, and Scott Barrett Ruth Lehmann and Gertrud Schüpbach 30 Honoring William Labov with the Talcott Parsons Prize William Labov CONTENTS 5 Among the contributors to the Dædalus issue on “Immigration, Nativism & Race” (left to right): Douglas S. Massey (guest editor), Christopher Sebastian Parker, and Cecilia Menjívar Our Work 5 Dædalus Explores Immigration, Nativism & Race in the United States 7 Advancing Civil Justice Access in the 21st Century 7 10 New Reports on the Earnings & Job Outcomes of College Graduates 14 Our Common Purpose in Communities Across the Country Members 53 In Memoriam: Louis W. -
NSABB June-July 2005 Meeting Agenda
First Meeting of the National Science Advisory Board for Biosecurity June 30 – July 1, 2005 Hyatt Regency Bethesda 7400 Wisconsin Ave. Bethesda, Maryland, 20814 USA Hotel Phone: 301-657-1234 Agenda Webcast: To watch the live webcast of the meeting, click here. The webcast can only be viewed when the meeting is in session at 8:00am-6:00pm on June 30 and at 8:00am-1:30pm on July 1 Eastern Time. You will need RealOne Player to view the webcast. If you do not already have RealOne Player on your computer, download here. Presentation slides: To access the following PowerPoint presentations, click on the presentation titles below. June 30, 2005 Opening Remarks and Swearing in Ceremony Elias Zerhouni, M.D. Director of the National Institutes of Health (NIH) Chair's Remarks and Agenda Overview Dennis L. Kasper, M.D. NSABB Chair Harvard Medical School Introduction of NSABB Members NSABB Structure and Operations Thomas Holohan, M.D. NSABB Executive Director, NIH Office of Biotechnology Activities Break Perspectives on Biosecurity in the Life Sciences NSABB Voting Members Impetus for NSABB: Enhancing Biosecurity on the Life Sciences Rajeev Venkayya, M.D. Special Assistant to the President, Senior Director for Biological and Chemical Defense White House Homeland Security Council Perspectives on Biosecurity in the Life Sciences NSABB Ex Officio Members Lunch Session I- The Development of Criteria for Identifying Dual Use Research and Research Results Introduction: Issues of Relevance to Criteria Development Arturo Casadevall, M.D., Ph.D. Professor of Medicine and of Microbiology & Immunology and Chief of Infectious Diseases Albert Einstein College of Medicine National Research Council Perspective: Experiments of Concern Ron Atlas, Ph.D. -
Applied Category Theory for Genomics – an Initiative
Applied Category Theory for Genomics { An Initiative Yanying Wu1,2 1Centre for Neural Circuits and Behaviour, University of Oxford, UK 2Department of Physiology, Anatomy and Genetics, University of Oxford, UK 06 Sept, 2020 Abstract The ultimate secret of all lives on earth is hidden in their genomes { a totality of DNA sequences. We currently know the whole genome sequence of many organisms, while our understanding of the genome architecture on a systematic level remains rudimentary. Applied category theory opens a promising way to integrate the humongous amount of heterogeneous informations in genomics, to advance our knowledge regarding genome organization, and to provide us with a deep and holistic view of our own genomes. In this work we explain why applied category theory carries such a hope, and we move on to show how it could actually do so, albeit in baby steps. The manuscript intends to be readable to both mathematicians and biologists, therefore no prior knowledge is required from either side. arXiv:2009.02822v1 [q-bio.GN] 6 Sep 2020 1 Introduction DNA, the genetic material of all living beings on this planet, holds the secret of life. The complete set of DNA sequences in an organism constitutes its genome { the blueprint and instruction manual of that organism, be it a human or fly [1]. Therefore, genomics, which studies the contents and meaning of genomes, has been standing in the central stage of scientific research since its birth. The twentieth century witnessed three milestones of genomics research [1]. It began with the discovery of Mendel's laws of inheritance [2], sparked a climax in the middle with the reveal of DNA double helix structure [3], and ended with the accomplishment of a first draft of complete human genome sequences [4]. -
And Should Not, Change Toxic Tort Causation Doctrine
THE MORE WE KNOW, THE LESS INTELLIGENT WE ARE? - HOW GENOMIC INFORMATION SHOULD, AND SHOULD NOT, CHANGE TOXIC TORT CAUSATION DOCTRINE Steve C. Gold* Advances in genomic science are rapidly increasing our understanding of dis- ease and toxicity at the most fundamental biological level. Some say this heralds a new era of certainty in linking toxic substances to human illness in the courtroom. Others are skeptical. In this Article I argue that the new sciences of molecular epidemiology and toxicogenomics will evince both remarkable explanatory power and intractable complexity. Therefore, even when these sciences are brought to bear, toxic tort claims will continue to present their familiar jurisprudential problems. Nevertheless, as genomic information is used in toxic tort cases, the sci- entific developments will offer courts an opportunity to correct mistakes of the past. Courts will miss those opportunities, however, if they simply transfer attitudesfrom classical epidemiology and toxicology to molecular and genomic knowledge. Using the possible link between trichloroethyleneand a type of kidney cancer as an exam- ple, I describe several causation issues where courts can, if they choose, improve doctrine by properly understanding and utilizing genomic information. L Introduction ............................................... 370 II. Causation in Toxic Torts Before Genomics ................... 371 A. The Problem .......................................... 371 B. Classical Sources of Causation Evidence ................ 372 C. The Courts Embrace Epidemiology - Perhaps Too Tightly ................................................ 374 D. Evidence Meets Substance: Keepers of the Gate ......... 379 E. The Opposing Tendency ................................ 382 III. Genomics, Toxicogenomics, and Molecular Epidemiology: The M ore We Know ........................................ 383 A. Genetic Variability and "Background" Risk .............. 384 B. Genetic Variability and Exposure Risk ................... 389 C. -
The Nobel Prize Sweden.Se
Facts about Sweden: The Nobel Prize sweden.se The Nobel Prize – the award that captures the world’s attention The Nobel Prize is considered the most prestigious award in the world. Prize- winning discoveries include X-rays, radioactivity and penicillin. Peace Laureates include Nelson Mandela and the 14th Dalai Lama. Nobel Laureates in Literature, including Gabriel García Márquez and Doris Lessing, have thrilled readers with works such as 'One Hundred Years of Solitude' and 'The Grass is Singing'. Every year in early October, the world turns Nobel Day is 10 December. For the prize its gaze towards Sweden and Norway as the winners, it is the crowning point of a week Nobel Laureates are announced in Stockholm of speeches, conferences and receptions. and Oslo. Millions of people visit the website At the Nobel Prize Award Ceremony in of the Nobel Foundation during this time. Stockholm on that day, the Laureates in The Nobel Prize has been awarded to Physics, Chemistry, Physiology or Medicine, people and organisations every year since and Literature receive a medal from the 1901 (with a few exceptions such as during King of Sweden, as well as a diploma and The Nobel Banquet is World War II) for achievements in physics, a cash award. The ceremony is followed a magnificent party held chemistry, physiology or medicine, literature by a gala banquet. The Nobel Peace Prize at Stockholm City Hall. and peace. is awarded in Oslo the same day. Photo: Henrik Montgomery/TT Henrik Photo: Facts about Sweden: The Nobel Prize sweden.se Prize in Economic Sciences prize ceremonies. -
Uncovering REDD+ Readiness in Mexico: Actors, Discourses and Benefit-Sharing
Uncovering REDD+ readiness in Mexico: Actors, discourses and benefit-sharing PhD Thesis Jovanka Špirić Under the supervision of: Dr. Esteve Corbera (UAB) Dr. Victoria Reyes-García (ICREA-UAB) Dr. Luciana Porter-Bolland (INECOL) PhD Programme in Environmental Science and Technology Institut de Ciència i Tecnologia Ambientals, ICTA Universitat Autònoma de Barcelona, UAB December 2015 Mojoj porodici Abstract Reducing Emissions from Deforestation and forest Degradation, plus conservation, sustainable management of forests and enhancement of forest carbon stocks (REDD+) is an international policy mechanism that seeks to mitigate climate change, while potentially alleviating poverty and contributing towards biodiversity conservation in developing countries. The United Nations Framework Convention on Climate Change (UNFCCC) laid the foundations for REDD+ design and implementation in 2005 and the mechanism’s architecture was finalised in 2015. During that period, parties to the UNFCCC debated and developed procedures and guidelines on REDD+ technical and governance issues, including for example how to guarantee the meaningful participation of all relevant stakeholders and how to respect the rights of indigenous peoples and local communities. In parallel, several developing countries, supported by multilateral and bilateral aid, entered the so-called REDD+ readiness phase and started developing national strategies for implementing REDD+ activities through specific policies and actions. This thesis addresses three main issues of concern for REDD+ scholars and practitioners using Mexico’s readiness process as an example. First, it analyses the design and legitimacy of the institutional arrangements established by the Mexican government to draft the REDD+ national strategy. Second, it identifies the REDD+ discourses mobilised by the actors involved in the country’s REDD+ readiness process and it highlights how such discourses are reflected in national policy documents, thus shedding light on dominant ideas and narratives permeating into the national strategy. -
Masthead (PDF)
Proceedings of the National Academy ofPNAS Sciences of the United States of America www.pnas.org PRESIDENT OF Robert G. Roeder Geophysics John J. Mekalanos THE ACADEMY Michael Rosbash Michael L. Bender Peter Palese Ralph J. Cicerone David D. Sabatini Thomas E. Shenk Gertrud M. Schupbach Human Environmental Thomas J. Silhavy SENIOR EDITOR Robert Tjian Sciences Peter K. Vogt Solomon H. Snyder Susan Hanson Cellular and Molecular Physics ASSOCIATE EDITORS Neuroscience Immunology Anthony Leggett William C. Clark Pietro V. De Camilli Peter Cresswell Paul C. Martin Alan Fersht Richard L. Huganir Douglas T. Fearon Jack Halpern L. L. Iversen Richard A. Flavell Physiology and Jeremy Nathans Charles F. Stevens Dan R. Littman Pharmacology Thomas C. Su¨dhof Tak Wah Mak Susan G. Amara Joseph S. Takahashi William E. Paul David Julius EDITORIAL BOARD Hans Thoenen Michael Sela Ramon Latorre Ralph M. Steinman Masashi Yanagisawa Animal, Nutritional, and Chemistry Applied Microbial Sciences Stephen J. Benkovic Mathematics Plant Biology David L. Denlinger Bruce J. Berne Richard V. Kadison Maarten J. Chrispeels R. Michael Roberts Harry B. Gray Robion C. Kirby Enrico Coen Robert Haselkorn Linda J. Saif Mark A. Ratner George H. Lorimer Ryuzo Yanagimachi Barry M. Trost Medical Genetics, Hematology, and Nicholas J. Turro Anthropology Oncology Plant, Soil, and Charles T. Esmon Microbial Sciences Jeremy A. Sabloff Computer and Joseph L. Goldstein Roger N. Beachy Information Sciences Mark T. Groudine Steven E. Lindow Applied Mathematical Sciences Shafrira Goldwasser David O. Siegmund Tony Hunter M. S. Swaminathan Philip W. Majerus Susan R. Wessler Economic Sciences Newton E. Morton Applied Physical Sciences Ronald W. -
Pomona College Magazine Fall/Winter 2020: the New (Ab
INSIDE:THE NEW COLLEGE MAGAZINE (AB)NORMAL • The Economy • Childcare • City Life • Dating • Education • Movies • Elections Fall-Winter 2020 • Etiquette • Food • Housing •Religion • Sports • Tourism • Transportation • Work & more Nobel Laureate Jennifer Doudna ’85 HOMEPAGE Together in Cyberspace With the College closed for the fall semester and all instruction temporarily online, Pomona faculty have relied on a range of technologies to teach their classes and build community among their students. At top left, Chemistry Professor Jane Liu conducts a Zoom class in Biochemistry from her office in Seaver North. At bottom left, Theatre Professor Giovanni Molina Ortega accompanies students in his Musical Theatre class from a piano in Seaver Theatre. At far right, German Professor Hans Rindesbacher puts a group of beginning German students through their paces from his office in Mason Hall. —Photos by Jeff Hing STRAY THOUGHTS COLLEGE MAGAZINE Pomona Jennifer Doudna ’85 FALL/WINTER 2020 • VOLUME 56, NO. 3 2020 Nobel Prize in Chemistry The New Abnormal EDITOR/DESIGNER Mark Wood ([email protected]) e’re shaped by the crises of our times—especially those that happen when ASSISTANT EDITOR The Prize Wwe’re young. Looking back on my parents’ lives with the relative wisdom of Robyn Norwood ([email protected]) Jennifer Doudna ’85 shares the 2020 age, I can see the currents that carried them, turning them into the people I knew. Nobel Prize in Chemistry for her work with They were both children of the Great Depression, and the marks of that experi- BOOK EDITOR the CRISPR-Cas9 molecular scissors. Sneha Abraham ([email protected]) ence were stamped into their psyches in ways that seem obvious to me now. -
Dean, School of Science
Dean, School of Science School of Science faculty members seek to answer fundamental questions about nature ranging in scope from the microscopic—where a neuroscientist might isolate the electrical activity of a single neuron—to the telescopic—where an astrophysicist might scan hundreds of thousands of stars to find Earth-like planets in their orbits. Their research will bring us a better understanding of the nature of our universe, and will help us address major challenges to improving and sustaining our quality of life, such as developing viable resources of renewable energy or unravelling the complex mechanics of Alzheimer’s and other diseases of the aging brain. These profound and important questions often require collaborations across departments or schools. At the School of Science, such boundaries do not prevent people from working together; our faculty cross such boundaries as easily as they walk across the invisible boundary between one building and another in our campus’s interconnected buildings. Collaborations across School and department lines are facilitated by affiliations with MIT’s numerous laboratories, centers, and institutes, such as the Institute for Data, Systems, and Society, as well as through participation in interdisciplinary initiatives, such as the Aging Brain Initiative or the Transiting Exoplanet Survey Satellite. Our faculty’s commitment to teaching and mentorship, like their research, is not constrained by lines between schools or departments. School of Science faculty teach General Institute Requirement subjects in biology, chemistry, mathematics, and physics that provide the conceptual foundation of every undergraduate student’s education at MIT. The School faculty solidify cross-disciplinary connections through participation in graduate programs established in collaboration with School of Engineering, such as the programs in biophysics, microbiology, or molecular and cellular neuroscience. -
Speaker Biographies June 29, 2021
Summit on Diversity, Equity, Inclusion, and Anti-Racism in 21st Century STEMM Organizations June 29-30, 2021 | Virtual Event Speaker Biographies June 29, 2021: The systemic and structural nature of racism and bias Welcoming Remarks John L. Anderson is president of the National Academy of Engineering since July 1, 2019. He was born in Wilmington, DE, and received his undergraduate degree from the University of Delaware in 1967 and PhD degree from the University of Illinois at Urbana-Champaign in 1971, both in chemical engineering. He was most recently Distinguished Professor of Chemical Engineering and president (2007–2015) of the Illinois Institute of Technology (IIT). Before that he was provost and executive vice president at Case Western Reserve University (2004–2007), following 28 years at Carnegie Mellon University, including 8 years as dean of the College of Engineering and 11 years as head of the Chemical Engineering Department. He began his professional career as an assistant professor of chemical engineering at Cornell University (1971–1976). Dr. Anderson was elected to the NAE in 1992 for contributions to the understanding of colloidal hydro-dynamics and membrane transport phenomena and was elected an NAE councillor in 2015. His service also includes numerous National Academies activities, such as the Committee on Determining Basic Research Needs to Interrupt the Improvised Explosive Device Delivery Chain (chair); Committee on Review of Existing and Potential Standoff Explosives Detection Techniques (chair); Organizing Committee for the National Security and Homeland Defense Workshop (cochair); Board on Chemical Sciences and Technology (cochair); and Ford Foundation Minority Postdoctoral Review Panel on Physical Sciences, Mathematics, and Engineering.