2009 NIH Director's Transformative Research Award Reviewers
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Applied Category Theory for Genomics – an Initiative
Applied Category Theory for Genomics { An Initiative Yanying Wu1,2 1Centre for Neural Circuits and Behaviour, University of Oxford, UK 2Department of Physiology, Anatomy and Genetics, University of Oxford, UK 06 Sept, 2020 Abstract The ultimate secret of all lives on earth is hidden in their genomes { a totality of DNA sequences. We currently know the whole genome sequence of many organisms, while our understanding of the genome architecture on a systematic level remains rudimentary. Applied category theory opens a promising way to integrate the humongous amount of heterogeneous informations in genomics, to advance our knowledge regarding genome organization, and to provide us with a deep and holistic view of our own genomes. In this work we explain why applied category theory carries such a hope, and we move on to show how it could actually do so, albeit in baby steps. The manuscript intends to be readable to both mathematicians and biologists, therefore no prior knowledge is required from either side. arXiv:2009.02822v1 [q-bio.GN] 6 Sep 2020 1 Introduction DNA, the genetic material of all living beings on this planet, holds the secret of life. The complete set of DNA sequences in an organism constitutes its genome { the blueprint and instruction manual of that organism, be it a human or fly [1]. Therefore, genomics, which studies the contents and meaning of genomes, has been standing in the central stage of scientific research since its birth. The twentieth century witnessed three milestones of genomics research [1]. It began with the discovery of Mendel's laws of inheritance [2], sparked a climax in the middle with the reveal of DNA double helix structure [3], and ended with the accomplishment of a first draft of complete human genome sequences [4]. -
HPV Vaccine: Global Effort Defeats Cancer-Causing Virus
HPV Vaccine: Global Effort Defeats Cancer-Causing Virus Georgetown University German Cancer Research Ctr (DKFZ) National Institutes of Health (NIH) University of Queensland, Australia University of Rochester Medical Center The world’s first vaccine against human papilloma viruses (HPV) is also the world’s first vaccine developed to specifically combat cancer. Distributed under the brand names Gardasil and Cervarix, by Merck & Co. and GlaxoSmithKline, respectively, the vaccine is widely known for its effectiveness against precursors of cervical cancer in women. The breakthrough medical advancement, recently approved for use in males, stands to benefit men too. According to the World Health Organization (WHO), some 500,000 women a year worldwide develop cervical cancer, and 274,000 die from the disease. Cervical cancer is caused by HPV and is the most common cancer affecting women in developing countries. The virus, however, does not restrain its attack to women or even to the female reproductive tract; there are more than 100 known types of HPV, and at least 13 are cancer-causing. WHO estimates it also causes 90 percent of anal cancers, 40 percent of cancers of the external genitalia, at least 12 percent of oropharyngeal (throat) cancer cases and at least 3 percent of oral cancer cases. In the United States, HPV is the most common sexually transmitted disease, according to the Centers for Disease Control and Prevention, and will infect at least 50 percent of sexually active people at some point in their lives. In other words, HPV strikes more humans than it spares and it continues to spread. The need to confront and prevent this threat is universally recognized. -
Masthead (PDF)
Proceedings of the National Academy ofPNAS Sciences of the United States of America www.pnas.org PRESIDENT OF Robert G. Roeder Geophysics John J. Mekalanos THE ACADEMY Michael Rosbash Michael L. Bender Peter Palese Ralph J. Cicerone David D. Sabatini Thomas E. Shenk Gertrud M. Schupbach Human Environmental Thomas J. Silhavy SENIOR EDITOR Robert Tjian Sciences Peter K. Vogt Solomon H. Snyder Susan Hanson Cellular and Molecular Physics ASSOCIATE EDITORS Neuroscience Immunology Anthony Leggett William C. Clark Pietro V. De Camilli Peter Cresswell Paul C. Martin Alan Fersht Richard L. Huganir Douglas T. Fearon Jack Halpern L. L. Iversen Richard A. Flavell Physiology and Jeremy Nathans Charles F. Stevens Dan R. Littman Pharmacology Thomas C. Su¨dhof Tak Wah Mak Susan G. Amara Joseph S. Takahashi William E. Paul David Julius EDITORIAL BOARD Hans Thoenen Michael Sela Ramon Latorre Ralph M. Steinman Masashi Yanagisawa Animal, Nutritional, and Chemistry Applied Microbial Sciences Stephen J. Benkovic Mathematics Plant Biology David L. Denlinger Bruce J. Berne Richard V. Kadison Maarten J. Chrispeels R. Michael Roberts Harry B. Gray Robion C. Kirby Enrico Coen Robert Haselkorn Linda J. Saif Mark A. Ratner George H. Lorimer Ryuzo Yanagimachi Barry M. Trost Medical Genetics, Hematology, and Nicholas J. Turro Anthropology Oncology Plant, Soil, and Charles T. Esmon Microbial Sciences Jeremy A. Sabloff Computer and Joseph L. Goldstein Roger N. Beachy Information Sciences Mark T. Groudine Steven E. Lindow Applied Mathematical Sciences Shafrira Goldwasser David O. Siegmund Tony Hunter M. S. Swaminathan Philip W. Majerus Susan R. Wessler Economic Sciences Newton E. Morton Applied Physical Sciences Ronald W. -
CURRICULUM VITAE George M. Weinstock, Ph.D
CURRICULUM VITAE George M. Weinstock, Ph.D. DATE September 26, 2014 BIRTHDATE February 6, 1949 CITIZENSHIP USA ADDRESS The Jackson Laboratory for Genomic Medicine 10 Discovery Drive Farmington, CT 06032 [email protected] phone: 860-837-2420 PRESENT POSITION Associate Director for Microbial Genomics Professor Jackson Laboratory for Genomic Medicine UNDERGRADUATE 1966-1967 Washington University EDUCATION 1967-1970 University of Michigan 1970 B.S. (with distinction) Biophysics, Univ. Mich. GRADUATE 1970-1977 PHS Predoctoral Trainee, Dept. Biology, EDUCATION Mass. Institute of Technology, Cambridge, MA 1977 Ph.D., Advisor: David Botstein Thesis title: Genetic and physical studies of bacteriophage P22 genomes containing translocatable drug resistance elements. POSTDOCTORAL 1977-1980 Postdoctoral Fellow, Department of Biochemistry TRAINING Stanford University Medical School, Stanford, CA. Advisor: Dr. I. Robert Lehman. ACADEMIC POSITIONS/EMPLOYMENT/EXPERIENCE 1980-1981 Staff Scientist, Molec. Gen. Section, NCI-Frederick Cancer Research Facility, Frederick, MD 1981-1983 Staff Scientist, Laboratory of Genetics and Recombinant DNA, NCI-Frederick Cancer Research Facility, Frederick, MD 1981-1984 Adjunct Associate Professor, Department of Biological Sciences, University of Maryland, Baltimore County, Catonsville, MD 1983-1984 Senior Scientist and Head, DNA Metabolism Section, Lab. Genetics and Recombinant DNA, NCI-Frederick Cancer Research Facility, Frederick, MD 1984-1990 Associate Professor with tenure (1985) Department of Biochemistry -
2013 NCI Alliance for Nanotechnology in Cancer Annual Bulletin EDITOR-IN-CHIEF
2013 NCI Alliance for Nanotechnology in Cancer Annual Bulletin EDITOR-IN-CHIEF Piotr Grodzinski (NCI) SENIOR EDITOR Stephanie A. Morris (NCI) ASSOCIATE EDITOR(S) Dorothy Farrell (NCI) Lynn Hull (NCI) Mary Spiro (JHU) CONTRIBUTORS Martha Alexander (Rice CNPP) Michelle Berny-Lang (NCI) Dorothy Farrell (NCI) Emily Greenspan (NCI) Piotr Grodzinski (NCI) George Hinkal (NCI) Brenda Hugot (Boston CNTC) Lynn Hull (NCI) Contents Hannah Kim (Texas CCNE) 1 Introduction Julia Ljubimova (Cedars-Sinai CNPP) NIH Funding Opportunities Extend the Range Laura A. Miller (UIUC CNTC) 2 of Cancer Nanotechnology in Biomedical Research Sarah H. Petrosko (Northwestern CCNE) Mary Spiro (Johns Hopkins CCNE & CNTC) 6 Alliance Working Groups Provide Their Opinions to the Nanotechnology Community Li Tang (UIUC CNTC) Biana Godin Vilentchouk (Texas CCNE) 8 Crowdsourcing and the Dialogue Matthew Ware (Texas CCNE) on Nanotechnology in Cancer 9 Nano in the News DESIGN Danielle Peterson, Brio Design 12 Alliance Transitions INTRODUCTION BY DOROTHY FARRELL The third year of Phase II of the NCI Alliance for Nanotechnology These efforts included crowdsourcing strategies coordinated in Cancer was a busy and productive one for the Alliance. through a dedicated website (nanocancer.ideascale.com) and a Our investigators published over 300 papers in 2013, bringing Request for Information on the Directions and Needs for Cancer the total number of Alliance publications over the past three Nanotechnology (grants.nih.gov/grants/guide/notice-files/ years to approximately 1,100. Alliance research continues to NOT-CA-13-017.html). The insights gained through these forums be high profile and high impact, as measured by the quality are discussed in the Crowdsourcing section of the Bulletin. -
Molecular and Cellular Biology Volume 8 May 1988 Number 5
MOLECULAR AND CELLULAR BIOLOGY VOLUME 8 MAY 1988 NUMBER 5 Aaron J. Shatkin, Editor in Chief(1990) Randy W. Schekman, Editor Joan A. Steitz, Editor (1990) Center for Advanced (1992) Yale University Biotechnology and Medicine University of California New Haven, Conn. Piscataway, N.J. Berkeley Robert Tjian, Editor (1991) David J. L. Luck, Editor (1992) Louis Siminovitch, Editor (1990) University of California Rockefeller University Mount Sinai Hospital Berkeley New York, N.Y. Toronto, Canada Harold E. Varmus, Editor (1989) Steven L. McKnight, Editor (1992) University of California Carnegie Institution of Washington San Francisco Baltimore, Md. EDITORIAL BOARD Frederick W. Alt (1990) Michael Green (1988) Douglas Lowy (1990) Matthew P. Scott (1989) Susan Berget (1990) Jack F. Greenblatt (1988) Paul T. Magee (1988) Fred Sherman (1988) Arnold J. Berk (1988) Leonard P. Guarente (1988) James Manley (1989) Arthur Skoultchi (1988) Alan Bernstein (1990) Christine Guthrie (1989) Janet E. Mertz (1990) Barbara Sollner-Webb (1989) Barbara K. Birshtein (1990) James E. Haber (1990) Robert L. Metzenberg (1988) Frank Solomon (1988) J. Michael Bishop (1990) Hidesaburo Hanafusa (1989) Robert K. Mortimer (1988) Karen Sprague (1989) Michael R. Botchan (1990) Leland D. Hartwell (1990) Bernardo Nadal-Ginard (1990) Pamela Stanley (1988) David Botstein (1990) Ari Helenius (1990) Paul Neiman (1989) Nat Sternberg (1989) Bruce P. Brandhorst (1990) Ira Herskowitz (1990) Joseph R. Nevins (1990) Bruce Stiliman (1988) James R. Broach (1988) James B. Hicks (1989) Carol Newlon (1988) Kevin Struhl (1989) Joan Brugge (1988) Alan Hinnebusch (1988) Mary Ann Osley (1990) Bill Sugden (1988) Mario R. Capecchi (1990) Michael J. Holland (1990) Brad Ozanne (1989) Lawrence H. -
David Botstein 2015 Book.Pdf
Princeton University HONORS FACULTY MEMBERS RECEIVING EMERITUS STATUS May 2015 The biographical sketches were written by colleagues in the departments of those honored. Copyright © 2015 by The Trustees of Princeton University 550275 Contents Faculty Members Receiving Emeritus Status 2015 Steven L. Bernasek .......................3 David Botstein...........................6 Erhan Çinlar ............................8 Caryl Emerson.......................... 11 Christodoulos A. Floudas ................. 15 James L. Gould ......................... 17 Edward John Groth III ...................20 Philip John Holmes ......................23 Paul R. Krugman .......................27 Bede Liu .............................. 31 Alan Eugene Mann ......................33 Joyce Carol Oates .......................36 Clarence Ernest Schutt ...................39 Lee Merrill Silver .......................41 Thomas James Trussell ...................43 Sigurd Wagner .........................46 { 1 } { 2 } David Botstein avid Botstein was educated at Harvard (A.B. 1963) and the D University of Michigan (Ph.D. 1967). He joined the faculty of the Massachusetts Institute of Technology, rising through the ranks from instructor to professor of genetics. In 1987, he moved to Genentech, Inc. as vice president–science, and, in 1990, he joined Stanford University’s School of Medicine, where he was chairman of the Department of Genetics. In July, 2003 he became director of the Lewis-Sigler Institute for Integrative Genomics and the Anthony B. Evnin ’62 Professor of Genomics at Princeton University. David’s research has centered on genetics, especially the use of genetic methods to understand biological functions. His early work in bacterial genetics contributed to the discovery of transposable elements in bacteria and an understanding of their physical structures and genetic properties. In the early 1970s, he turned to budding yeast (Saccharomyces cerevisiae) and devised novel genetic methods to study the functions of the actin and tubulin cytoskeletons. -
Celebration of Teaching Program
Celebration of Teaching April 16, 2021 · Zoom · 1:00-3:00pm Program WELCOME & INTRODUCTION OF DEAN RASHID BASHIR Jay Mann, Director of AE3 REMARKS Rashid Bashir, Dean KEYNOTE ADDRESS Dr. Gilda Barabino President, Olin College of Engineering COLLINS SCHOLAR REFLECTION AND RECOGNITION Chris Migotsky, Faculty Teaching Programs Coordinator & Jay Mann Eleftharia Kontou (2019-2020) & Brad Solomon (2020-2021) CELEBRATING EXCELLENCE IN ENGINEERING EDUCATION Jonathan Makela, Associate Dean & Jay Mann SIIP POSTER SESSION Rashid Bashir Dean, Grainger College of Engineering Rashid Bashir is Dean of The Grainger College of Engineering, the Grainger Distinguished Chair in Engineering and Professor of Bioengineering at the University of Illinois at Urbana-Champaign (UIUC). He received the NSF Faculty Early Career Award, the 2012 IEEE EMBS Technical Achievement Award, the Pritzker Distinguished Lectureship Award from BMES in 2018, and the 2021 American Institute for Medical and Biological Engineering Professional Impact Award. He has been involved in 3 startups that have licensed his technologies. He was part of the core founding team and co-chair of the curriculum committee for the Carle Illinois College of Medicine. His research group is interested in developing new technologies for precision and personalized medicine, and 3D bio-fabrication of cellular systems. Using bionanotechnology, BioMEMS, and lab on chip, he is working at the interface of biology and engineering from the molecular to the tissue scale, and aiming to make an impact on grand challenges in health and medicine. Dr. Gilda Barabino President, Olin College of Engineering Gilda A. Barabino is President of Olin College of Engineering, and Professor of Biomedical and Chemical Engineering. -
Celebrating Years of 60Science Welcome to the 60Th Anni- Versary Symposium of the Miller Institute
Celebrating Years of 60Science Welcome to the 60th Anni- versary Symposium of the Miller Institute. In an age of ever increasing special- ization, the Miller Institute stands apart as one of the very few enterprises to embrace all of Science as its purview. For 60 years the Miller Institute has provided generous sup- port to some of the lead- ing postdoctoral fellows in all fields of science, has supported extended visits from famous scientists from around the world, and has provided critical adminis- trative and teaching relief for Berkeley faculty at par- ticularly important points in their career. This grand tradition lives on, even in the face of ever-greater challenges, with a refresh- ing emphasis on clarity in cross-discipline communi- cation. We have assembled a panel of eight luminaries drawn from past and pres- ent members of the Miller Institute each of whom leads their field with cre- ative research at the fron- tiers of human knowledge. So relax, enjoy, and be sure to ask that question that you always wanted to have answered. Jasper Rine, Professor of Genetics and Developmental Biology Chair, Miller Institute 60th 60th Anniversary Agenda Friday, January 15 – Sunday, January 17, 2016 Friday evening - Alumni House 5:00 - 7:00 Reception Saturday – Stanley Hall 8:00 - 8:45 Registration 8:45 - 9:00 Welcome 9:00 - 11:45 Maha Mahadevan: “On growth and form: geometry, physics and biology” Alice Guionnet: “About Universal Laws” Roger Bilham: “Earthquakes and Money: Frail Buildings, Philanthropic Engineers and a Few Corrupt Bad Guys -
Annual Rpt 2004 For
I N S T I T U T E for A D V A N C E D S T U D Y ________________________ R E P O R T F O R T H E A C A D E M I C Y E A R 2 0 0 3 – 2 0 0 4 EINSTEIN DRIVE PRINCETON · NEW JERSEY · 08540-0631 609-734-8000 609-924-8399 (Fax) www.ias.edu Extract from the letter addressed by the Institute’s Founders, Louis Bamberger and Mrs. Felix Fuld, to the Board of Trustees, dated June 4, 1930. Newark, New Jersey. It is fundamental in our purpose, and our express desire, that in the appointments to the staff and faculty, as well as in the admission of workers and students, no account shall be taken, directly or indirectly, of race, religion, or sex. We feel strongly that the spirit characteristic of America at its noblest, above all the pursuit of higher learning, cannot admit of any conditions as to personnel other than those designed to promote the objects for which this institution is established, and particularly with no regard whatever to accidents of race, creed, or sex. TABLE OF CONTENTS 4·BACKGROUND AND PURPOSE 7·FOUNDERS, TRUSTEES AND OFFICERS OF THE BOARD AND OF THE CORPORATION 10 · ADMINISTRATION 12 · PRESENT AND PAST DIRECTORS AND FACULTY 15 · REPORT OF THE CHAIRMAN 20 · REPORT OF THE DIRECTOR 24 · OFFICE OF THE DIRECTOR - RECORD OF EVENTS 31 · ACKNOWLEDGMENTS 43 · REPORT OF THE SCHOOL OF HISTORICAL STUDIES 61 · REPORT OF THE SCHOOL OF MATHEMATICS 81 · REPORT OF THE SCHOOL OF NATURAL SCIENCES 107 · REPORT OF THE SCHOOL OF SOCIAL SCIENCE 119 · REPORT OF THE SPECIAL PROGRAMS 139 · REPORT OF THE INSTITUTE LIBRARIES 143 · INDEPENDENT AUDITORS’ REPORT 3 INSTITUTE FOR ADVANCED STUDY BACKGROUND AND PURPOSE The Institute for Advanced Study was founded in 1930 with a major gift from New Jer- sey businessman and philanthropist Louis Bamberger and his sister, Mrs. -
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Addressing Problems Worth Solving The challenges we are confronting worldwide are both complex and daunting. In the next 20 years, the most important inventions will be those that address critical social and environmental issues, reaching and serving communities with the greatest needs. These inventions will deliver meaningful change, solve urgent problems, and create sustainable economic value for all. The Lemelson Foundation focuses on problems that are worth solving—and not simply problems that can be solved. We recognize the need for a strong supportive invention ecosystem to make this happen. We seek to inspire inventors to know that they can make a difference. We work to ensure that the next generation of inventors can become agents of positive change. Find out more about how we provide support to foster inventions to improve lives at: www.lemelson.org/impactinventing Distinguished Colleagues: On behalf of the Board of Directors, it is my distinct pleasure to welcome you to the fourth annual meeting of the National Academy of Inventors, held this year at the California Institute of Technology and the Langham Huntington Hotel in Pasadena. In addition to a compelling program filled with outstanding speakers, our meet- ing sets the stage for our continued growth and future as an organization. We are grateful for the support of our sponsors and host institutions in making this conference possible. We thank our presenters, panelists, co-chairs, and the conference program committee for their hard work, and we thank you for being here. We are delighted to welcome Steven Chu, Esther Takeuchi and Richard DiMarchi as our featured keynote speakers and look forward to hearing their insights on innovation. -
The Center for Food Safety Engineering G
The Center for Food Safety Engineeringg 2007 - 2008 Research Report “Collaborating to make our food safer” The mission of the Center for Food Safety Engineering is to develop new knowledge, technologies and systems for detection and prevention of chemical and microbial contamination of foods. Through CFSE, Purdue University positions itself as a national leader in multi- disciplinary food safety research. Our multi- disciplinary approach, including a strong engineering component, makes Purdue University truly unique. 2007-2008 Research Report 2 Welcome from the Director • Message from Richard Linton, Center Director 2 Message from USDA • Message from our Partnership with USDA-ARS 3 Multipathogen screening using immunomicroarray • Arun Bhunia 4 Optical biosensors for food pathogen detection • Arun Bhunia 5 Optical forward scattering for bacterial colony differentiation and identifi cation • Arun Bhunia, E. Daniel. Hirleman, J. Paul Robinson 6 Immunocapture real-time PCR to detect mycotoxigenic mold spores in grains • Maribeth A. Cousin, Charles P. Woloshuk 7 Detection of foodborne pathogens via an integrated spectroscopy and biosensor-based approach • Joseph Irudayaraj, Lisa Mauer, Chitrita DebRoy, Pina Fratamico 8 Nanoparticle-based DNA-multiplexed probes for pathogen detection using confocal raman microscopy • Joseph Irudayaraj 9 Engineering of biosystems for the detection of Listeria monocytogenes in foods • Michael R. Ladisch, Rashid Bashir, Arun Bhunia, J. Paul Robinson 10 Spotlight on USDA-ARS Scientists 12 Rapid, quantitative, and