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HPV Vaccine: Global Effort Defeats Cancer-Causing Virus
HPV Vaccine: Global Effort Defeats Cancer-Causing Virus Georgetown University German Cancer Research Ctr (DKFZ) National Institutes of Health (NIH) University of Queensland, Australia University of Rochester Medical Center The world’s first vaccine against human papilloma viruses (HPV) is also the world’s first vaccine developed to specifically combat cancer. Distributed under the brand names Gardasil and Cervarix, by Merck & Co. and GlaxoSmithKline, respectively, the vaccine is widely known for its effectiveness against precursors of cervical cancer in women. The breakthrough medical advancement, recently approved for use in males, stands to benefit men too. According to the World Health Organization (WHO), some 500,000 women a year worldwide develop cervical cancer, and 274,000 die from the disease. Cervical cancer is caused by HPV and is the most common cancer affecting women in developing countries. The virus, however, does not restrain its attack to women or even to the female reproductive tract; there are more than 100 known types of HPV, and at least 13 are cancer-causing. WHO estimates it also causes 90 percent of anal cancers, 40 percent of cancers of the external genitalia, at least 12 percent of oropharyngeal (throat) cancer cases and at least 3 percent of oral cancer cases. In the United States, HPV is the most common sexually transmitted disease, according to the Centers for Disease Control and Prevention, and will infect at least 50 percent of sexually active people at some point in their lives. In other words, HPV strikes more humans than it spares and it continues to spread. The need to confront and prevent this threat is universally recognized. -
2009 NIH Director's Transformative Research Award Reviewers
2009 NIH Director’s Transformative Research Award Reviewers Editorial Board Members Chairs David Botstein Keith Robert Yamamoto Princeton University University of California, San Francisco Members John T. Cacioppo Myron P. Gutmann University of Chicago Inter-University Consortium for Political and Social Research Aravinda Chakravarti Johns Hopkins School of Medicine Nola M. Hylton-Watson University of California, San Francisco Garret A. Fitzgerald Cecil B. Pickett University of Pennsylvania Biogen Idec Alfred G. Gilman Susan S. Taylor University of Texas Southwestern Medical University of California at San Diego Center Michael J. Welsh University of Iowa Mail Reviewers Craig Kendall Abbey Margaret Ashcroft University of California, Santa Barbara Division of Medicine Samuel Achilefu Richard Herbert Aster School of Medicine Blood Research Institute Manuel Ares Arleen D. Auerbach University of California Rockefeller University Bruce A. Armitage J. Thomas August Carnegie Mellon University Johns Hopkins University Mark A. Arnold Kevin A. Ault University of Iowa Emory University School of Medicine David C. Aron Jennifer Bates Averill Case Western Reserve University University of New Mexico 1 Mary Helen Barcellos-Hoff Leslie A. Bruggeman New York University School of Medicine Case Western Reserve University David P. Bartel Peter Burkhard New Cambrige Center University of Connecticut Ralf Bartenschlager Alma L. Burlingame University of Heidelberg University of California, San Francisco Rashid Bashir Frederic D. Bushman University of Illinois at Urbana – Champaign University of Pennsylvania Carl A. Batt Robert William Caldwell Cornell University Medical College of Georgia Mark T. Bedford Phil Gordon Campbell Research Division Carnegie Mellon University Kevin D. Belfield Joseph Nicholas Cappella University of Central Florida University of Pennsylvania Andrew Steven Belmont William A. -
Graduate School-- New Brunswick
Graduate School-- New Brunswick Ca t a l o g 20 0 3 --20 0 5 Contents Academic Calendars 2 About the University 3 Graduate Study at the University 4 Other Graduate Study at the University 5 Degree Programs Available 6 Admission 8 Tuition and Fees 9 Financial Aid 11 Student Services 15 Academic Policies and Procedures 22 Degree Requirements 34 Programs, Faculty, and Courses 40 Research Centers, Bureaus, an d Institutes 215 Administration 221 Governance of the University 222 Divisions of the University 223 Index 228 Important Notice Please note that only the printed version of this catalog is the official document of Rutgers, The State University of New Jersey. While Rutgers offers its catalogs on the Internet as a convenience, the university’s online catalogs are unofficial, as is academic information offered at other Rutgers web sites. The university reserves the right for any reason to cancel or modify any course or program listed herein. In addition, individual course offerings and programs may vary from year to year as circumstances dictate. 1 Academic Calendars Dates are subject to change. 2003–2004 2004–2005 September September 2 Tuesday Fall term begins. 1 Wednesday Fall term begins. November 6 Monday Labor Day—No classes. 25 Tuesday Thursday classes meet. November 26 Wednesday Friday classes meet. 24 Wednesday No classes. 27 Thursday Thanksgiving recess begins. 25 Thursday Thanksgiving recess begins. 30 Sunday Thanksgiving recess ends. 28 Sunday Thanksgiving recess ends. December December 10 Wednesday Regular classes end. 13 Monday Regular classes end. 11 Thursday Reading period. 14 Tuesday Reading period. 12 Friday Reading period. -
The Big Ten: from Theory to Mainstream in Personalized Healthcare
The Big Ten: From Theory to Mainstream in Personalized Healthcare Item Type Brochure/Program Authors University of Maryland, Baltimore. School of Medicine Publication Date 2014-11-17 Keywords University of Maryland, Baltimore. School of Medicine--Events Download date 25/09/2021 10:24:23 Item License https://creativecommons.org/licenses/by-nc-nd/4.0/ Link to Item http://hdl.handle.net/10713/4300 The Big Ten: From Theory to Mainstream in Personalized Healthcare Tenth Annual Symposium on Translational Research in Molecular Pathology Date: Monday, November 17, 2014 Location: MSTF Auditorium University of Maryland, Baltimore 9:00am-4:00pm A Third Century Where Discovery Transforms 685 W. Baltimore Street Baltimore, MD21201 Medicine About the Division of Molecular Pathology The Division of Molecular Pathology Faculty The Division of Molecular Pathology is a research division within in the Department of Pathology, the University of Maryland School of Medicine, Burke, Allen P, M.D., Clinical Associate Professor which was established in 2005 under the leadership of Dr. Richard Y. Zhao. Castellani, Rudolph J Jr., M.D., Professor Currently there a total 17 faculty members in the division who conduct Constantine, Niel T., Ph.D., Professor research in various area of molecular pathology. Mission of the Division of Fulton, Amy M, Ph.D., Professor Molecular Pathology is to 1) support the Department of Pathology and the Hamburger, Anne W., PhD, Professor (retired) University of Maryland Medical School's mission for excellence in research, Jiang, Feng, M.D., Ph.D., Assistant Professor teaching and clinical services, 2) foster translational research in the Johnson, Jennifer K, Ph.D., Assistant Professor Department of Pathology in the area of Molecular Pathology, and 3) serve as a Luo, Jianyuan "Jack", PhD, Associate Professor research unit in reaching out and psromote inter-disciplinary collaboration in Mann, Dean L, M.D., Professor Molecular Pathology. -
Validate Innovative Skills by Establishing a Student Innovation and Invention Competition Program
Validate Innovative skills by Establishing a Student Innovation and Invention Competition Program Connie Wu Engineering and Patent Information Librarian Rutgers University 36 Patent and Trademark Resource Centers Seminar Alexandra, VA March 27, 2014 Abstract Student competition is an effective way to challenge students’ creative thinking, validate student innovative skills, and encourage student to prepare themselves for the workplaces after graduation. A PTRC on campus should play a key role in enhancing the endeavor. The presenter will introduce various student innovation and invention contest programs in the States and around world, and share the idea to establish such program at Rutgers University. ∗ Young Inventors Competitions Collegiate Inventors Competition http://www.invent.org/collegiate/ National Collegiate Inventors and Innovators Alliance http://nciia.org/competitions The Lemelson-MIT Awards for Invention and Innovation http://web.mit.edu/invent/a-main.html 3 College Inventors Competitions NEXUS Innovation Young Entrepreneurs http://iipdigital.usembassy.gov/st/english/article/2011/03/20110322173116su0.2460247.html #axzz1PYKtBVV8 U.S. Department of Energy Solar Decathlon http://www.solardecathlon.gov/about.html http://rei.rutgers.edu/index.php?option=com_content&task=view&id=150&Itemid=1 More Invention Contests and Competitions http://www.ideafinder.com/resource/youth/rpy-competitions.htm http://web.mit.edu/invent/r-archive-4.html College Inventors Competitions The GSEA (Global Student Entrepreneur Awards) is the premier global competition for high school, undergraduate and graduate students who own and operate businesses while attending college or university. Nominees compete against their peers from around the world. Founded in 1998 by Saint Louis University, the GSEA is now an Entrepreneurs’ Organization program. -
Dr. Richard Schlegel's Laboratory Co-Developed the Technology for The
Dr. Richard Schlegel’s laboratory co-developed the technology for the human papillomavirus (HPV) vaccine, which was approved by the U.S. Food and Drug Administration for clinical use in June 2006. HPV is the etiologic cause of cervical cancer, which is the second-leading cause of cancer deaths in women worldwide. Dr. Schlegel’s laboratory is currently developing, with grants from the Bill and Melinda Gates Foundation and the National Institutes of Health (NIH), second- and third-generation vaccines that could be used to prevent and treat HPV infections in the developing world, where almost all deaths from cervical cancer occur. Dr. Schlegel’s laboratory also utilizes a wide range of experimental approaches to investigate HPV/host interactions at the immunological, cellular, and molecular levels. In particular, his lab looks at three oncogenes in the papillomavirus genome with in vitro transforming activity: E5, E6, and E7, in order to understand the mechanism of papillomavirus-mediated cell transformation. Such approaches will aid in the design of viral-specific therapeutics. These approaches have led to the discovery that the antimalarial drug, dihydroartemisinin, is a potent therapeutic for cervical cancer cells. Lastly, the Schlegel laboratory is exploring the mechanism by which the HPV viruses induce cell immortalization. The property is unique to the “high-risk” HPVs present in human cancers and the laboratory has defined the Myc protein as being a critical target of the HPV E6 oncoprotein, thereby facilitating the transactivation of the hTERT gene and the consequent induction of telomerase activity. Collaborations: Dr. Schlegel and Dr. Byers have research projects in an NIH-funded PPG that was recently awarded to Dr. -
INTERNATIONAL RESEARCH and EXCHANGES BOARD UNIVERSITY ADMINISTRATION SUPPORT PROGRAM (UASP) Research Management at Rutgers
UASP Case Study Fellow: Tamar Gogua INTERNATIONAL RESEARCH AND EXCHANGES BOARD UNIVERSITY ADMINISTRATION SUPPORT PROGRAM (UASP) Research Management at Rutgers, The State University of New Jersey (RU) – Hands‐on Experience for Tbilisi State University (TSU) Case Study This case study was made possible by a grant from the International Research and Exchanges Board with funds provided by the Carnegie Corporation of New York, USA. The statements made and views are solely the responsibility of the author. Dr. Tamar Gogua Chief Specialist Department of Scientific Research and Development Ivane Javakhishvili Tbilisi State University Host advisor: Dr. Richard Mammone Management Topic: Research Management US Host: Rutgers, The State University of New Jersey January‐March, 2013 1 UASP Case Study Fellow: Tamar Gogua Content Acknowledgements ................................................................................................................................................. 3 Introduction and Methodology .......................................................................................................................... 4 RU and TSU – Brief Overview .............................................................................................................................. 6 Office of the Vice President for Research and Economic Development ............................................ 9 Office of Research and Sponsored Programs (ORSP) ........................................................................ 9 Office of Technology Commercialization -
CURRICULUM VITAE Alfred Bennett Jenson
CURRICULUM VITAE Alfred Bennett Jenson, MD 3715 Glen Bluff Road, Louisville, KY 40222 PERSONAL DATA Phone (Work) 1-502-852-1114 (Home) 1-502-417-9894 EDUCATION B.A., Texas Christian University, Texas, 1957-61 (Cum Laude) M.S., Baylor University (College of Medicine), Texas, l964-66 M.D., Baylor College of Medicine, Texas, l961-66, with honor Internship, Department of Medicine, Baylor College of Medicine Affiliated Hospital Program, l966-67 Residency, Department of Pathology, Baylor College of Medicine Affiliated Hospital Program, l967-70 American Association of Immunology Summer Course, l970 Research Trainee, U.S. Public Health Service, l967-71 (Joe Melnick, Ph.D., Mentor) Postdoctoral Fellow of the National Multiple Sclerosis Society, l973-75 Basic Program Officials Guide to Contracting, l979 Sabbatical, National German Cancer Institute (DKFZ), Heidelberg, Germany, October- December, 1999. POSITIONS Chief Resident, Pathology, Ben Taub General Hospital, Houston, Texas, l969-70 (Harlan Spjut, MD, Pathology Chief of Staff). Instructor, Department of Pathology, Baylor College of Medicine, l970-71. Instructor in Pathology, Department of Optometry, University of Houston, Texas, l970-71 Comparative Pathologist, USAR, Veterinary Medicine Division, Veterinary Pathology Branch, Edgewood Arsenal, MD, l971-73. Consultant, Cancer Cytology, Maryland State Department of Public Health and Hygiene, l972-73 Research Associate in Immunopathology, Scripps Clinic and Research Foundation, La Jolla, CA, 1973-75 (Frank Dixon, MD, Mentor). Senior Medical Surgeon, USPHS, Laboratory of Oral Medicine, National Institutes of Dental Research, National Institutes of Health, MD, l975-80 (Abner Notkins, MD, Laboratory Chief). Associate Professor, Department of Pathology, Georgetown University Schools of Medicine and Dentistry, l980-1989. Vice-Chairman, Department of Pathology, Georgetown University Schools of Medicine and Dentistry, l983-85. -
Viable Adenovirus Vaccine Prototypes: High-Level Production of a Papillomavirus Capsid Antigen from the Major Late Transcriptional Unit
Viable adenovirus vaccine prototypes: High-level production of a papillomavirus capsid antigen from the major late transcriptional unit Michael Berg†, Julie DiFatta†‡, Egbert Hoiczyk†, Richard Schlegel§, and Gary Ketner†¶ †W. Harry Feinstone Department of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, 615 North Wolfe Street, Baltimore, MD 21205; and §Department of Pathology, Georgetown University Medical Center, Washington, DC 20007 Communicated by Diane E. Griffin, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, February 4, 2005 (received for review October 21, 2004) Safe, effective, orally delivered, live adenovirus vaccines have been The eventual target of this work is human papillomavirus, the in use for three decades. Recombinant derivatives of the live etiologic agent of cervical cancer. More than 500,000 cases of adenovirus vaccines may prove an economical alternative to cur- cervical cancer are diagnosed annually, and Ͼ200,000 women die rent vaccines for a variety of diseases. To explore that possibility, each year from the disease (3). Vaccination with empty virus-like we constructed a series of recombinants that express the major particles (VLPs), which spontaneously assemble from recombi- capsid protein (L1) of canine oral papillomavirus (COPV), a model nant papillomavirus L1 capsid protein, confers immunity to for mucosal human papillomavirus (HPV) infection. Vaccination papillomavirus-induced tumors in animal systems (4–6). VLPs with virus-like particles (VLPs) composed of recombinant HPV L1 induce strong immune responses in humans (7, 8), and a VLP completely prevents persistent HPV infection [Koutsky, L. A., Ault, vaccine was 100% effective in preventing persistent infection K. A., Wheeler, C.