Table S1. Summary of publications related to Bifidobacterium breve M-16V.

Intervention Study model/subject Target Number of studies Grand total 60 Single strain of M-16V 31 In vitro/mice/rat Total 16 Preterm birth complications 1 Allergy 3 Safety/stability 5 Gut microbiota/others 7 Infant Total 14 Preterm birth complications 11 Allergy 3 Safety/stability 0 Gut microbiota/others 0 Children/adults/others Total 1 Preterm birth complications 0 Allergy 0 Safety/stability 0 Gut microbiota/others 1 Probiotics mixture with other strains 5 In vitro/mice/rat Total 0 Preterm birth complications 0 Allergy 0 Safety/stability 0 Gut microbiota/others 0 Infant Total 2 Preterm birth complications 1 Allergy 1 Safety/stability 0 Gut microbiota/others 0 Children/adults/others Total 3 Preterm birth complications 0 Allergy 1 Safety/stability 0 Gut microbiota/others 2 Synbiotics 24 In vitro/mice/rat Total 10 Preterm birth complications 0 Allergy 6 Safety/stability 0 Gut microbiota/others 4 Infant Total 11 Preterm birth complications 1 Allergy 8 Safety/stability 0 Gut microbiota/others 2 Children/adults/others Total 3 Preterm birth complications 0 Allergy 2 Safety/stability 0 Gut microbiota/others 1

Table S2. Articles related to Bifidobacterium breve M-16V

No. Inter- Study Target Article Title Authors Publisher Year DOI vention model/ subject Articles obtained from database search 1* M-16V Infant Preterm Review Bifidobacterium breve M-16V as a Athalye-Jape, Gayatri; Rao, JPEN. Journal 2018 10.1177/01486071177227 Probiotic for Preterm Infants: A Strain- Shripada; Simmer, Karen; Patole, of parenteral 49 Specific Systematic Review Sanjay and enteral nutrition 2 M-16V Infant Allergy Original Exploring Immune Development in Hulshof, Lies; Overbeek, Saskia A; Frontiers in 2018 10.3389/fimmu.2018.006 article Infants With Moderate to Severe Atopic Wyllie, Anne L; Chu, Mei Ling J N; immunology 30 Dermatitis Bogaert, Debby; de Jager, Wilco; Knippels, Leon M J; Sanders, Elisabeth A M; van Aalderen, Wim M C; Garssen, Johan; Van't Land, Belinda; Sprikkelman, Aline B 3 M-16V Infant Preterm Original Effect of probiotics on C-reactive protein Agrawal, S; Rao, S; Nathan, E A; Journal of 2018 10.3233/NPM-181763 article levels in preterm infants: Secondary Patole, S neonatal- analysis of a randomized controlled trial perinatal medicine 4 M-16V Infant Preterm Original Probiotics and antimicrobial protein and Strunk, Tobias; Hibbert, Julie; Acta 2017 10.1111/apa.13826 article peptide levels in preterm infants Doherty, Dorota; Granland, paediatrica Caitlyn; Trend, Stephanie; Simmer, Karen; Burgner, David; Patole, Sanjay; Currie, Andrew 5 M-16V Mice Allergy Original Dietary Intervention with β- Kostadinova, Atanaska I; Pablos- Frontiers in 2017 10.3389/fimmu.2017.013 article Lactoglobulin-Derived Peptides and a Tanarro, Alba; Diks, Mara A P; van immunology 03 Specific Mixture of Fructo- Esch, Betty C A M; Garssen, Johan; Oligosaccharides and Bifidobacterium Knippels, Léon M J; Willemsen, breve M-16V Facilitates the Prevention Linette E M of Whey-Induced Allergy in Mice by Supporting a Tolerance-Prone Immune Environment 6 M-16V Rat Immune Original Differences between live and heat-killed Sugahara, H; Yao, R; Odamaki, T; Beneficial 2017 10.3920/BM2016.0158 article bifidobacteria in the regulation of Xiao, J Z microbes immune function and the intestinal environment No. Inter- Study Target Article Title Authors Publisher Year DOI vention model/ subject 7* M-16V Infant Preterm Original Effect of Bifidobacterium breve M-16V Patole, Sanjay K; Keil, Anthony D; The journal of 2016 10.3109/14767058.2016.1 article supplementation on faecal bifidobacteria Nathan, Elizabeth; Doherty, maternal-fetal 147554. in growth restricted very preterm infants Dorota; Esvaran, Meera; Simmer, & neonatal - analysis from a randomised trial Karen N; Conway, Patricia medicine 8 M-16V Rat Immune Original Preclinical Immunomodulation by the Rigo-Adrover, Maria Del Mar; PloS one 2016 10.1371/journal.pone.016 article Probiotic Bifidobacterium breve M-16V Franch, Àngels; Castell, Margarida; 6082 in Early Life Pérez-Cano, Francisco José 9 M-16V Children IBS Review Probiotics for Irritable Bowel Syndrome: Giannetti, Eleonora; Staiano, Journal of 2016 10.1097/MPG.000000000 Clinical Data in Children Annamaria pediatric 0001220 gastroenterolo gy and nutrition 10* M-16V Infant Preterm Original Benefits of Bifidobacterium breve M-16V Patole, Sanjay K; Rao, Shripada C; PloS one 2016 10.1371/journal.pone.015 article Supplementation in Preterm Neonates - Keil, Anthony D; Nathan, 0775 A Retrospective Cohort Study Elizabeth A; Doherty, Dorota A; Simmer, Karen N 11* M-16V Rat Preterm Original Bifidobacterium breve prevents Satoh, T; Izumi, H; Iwabuchi, N; Beneficial 2016 10.3920/BM2015.0035 article necrotising enterocolitis by suppressing Odamaki, T; Namba, K; Abe, F; microbes inflammatory responses in a preterm rat Xiao, J Z model 12* M-16V Rat DSS Original Bifidobacterium breve alters immune Izumi, Hirohisa; Minegishi, Mario; Pediatric 2015 10.1038/pr.2015.115 article function and ameliorates DSS-induced Sato, Yohei; Shimizu, Takashi; research inflammation in weanling rats Sekine, Kazunori; Takase, Mitsunori 13* M-16V Infant Preterm Original Effect of Bifidobacterium breve M-16V Patole, Sanjay; Keil, Anthony D; PloS one 2014 10.1371/journal.pone.008 article supplementation on fecal bifidobacteria Chang, Annie; Nathan, Elizabeth; 9511 in preterm neonates--a randomised Doherty, Dorota; Simmer, Karen; double blind placebo controlled trial Esvaran, Meera; Conway, Patricia 14* M-16V In vitro Immune Original Immunoregulatory effect of Tomosada, Yohsuke; Villena, Julio; PloS one 2013 10.1371/journal.pone.005 article bifidobacteria strains in porcine Murata, Kozue; Chiba, Eriko; 9259 intestinal epithelial cells through Shimazu, Tomoyuki; Aso, Hisashi; modulation of ubiquitin-editing enzyme Iwabuchi, Noriyuki; Xiao, Jin- A20 expression zhong; Saito, Tadao; Kitazawa, Haruki

No. Inter- Study Target Article Title Authors Publisher Year DOI vention model/ subject 15* M-16V Rat Immune Original Effects of Bifidobacterium breve on Ohtsuka, Yoshikazu; Ikegami, Pediatric 2012 10.1038/pr.2011.11 article inflammatory gene expression in Takako; Izumi, Hirohisa; Namura, research neonatal and weaning rat intestine Mariko; Ikeda, Tomomi; Ikuse, Tamaki; Baba, Yosuke; Kudo, Takahiro; Suzuki, Ryuyo; Shimizu, Toshiaki 16 M-16V In vitro Immune Original Bifidobacterium breve - HT-29 cell line Boesten, R J; Schuren, F H J; Beneficial 2011 10.3920/BM2011.0005 article interaction: modulation of TNF-α Willemsen, L E M; Vriesema, A; microbes induced gene expression Knol, J; De Vos, W M 17 M-16V Infant Preterm Original Beneficial microbes for premature Yamashiro, Y; Nagata, S Beneficial 2010 10.3920/BM2010.0035 article infants, and children with malignancy microbes undergoing chemotherapy 18* M-16V Mice Safety Original Safety evaluation of probiotic Abe, Fumiaki; Muto, Masamichi; Anaerobe 2010 10.1016/j.anaerobe.2009. article bifidobacteria by analysis of mucin Yaeshima, Tomoko; Iwatsuki, 07.006 degradation activity and translocation Keiji; Aihara, Hiroaki; Ohashi, ability Yuji; Fujisawa, Tomohiko 19* M-16V Mice Allergy Original Oral treatment with probiotics reduces Hougee, S; Vriesema, A J M; International 2010 10.1159/000236000 article allergic symptoms in ovalbumin- Wijering, S C; Knippels, L M J; archives of sensitized mice: a bacterial strain Folkerts, G; Nijkamp, F P; Knol, J; allergy and comparative study Garssen, J immunology 20* M-16V Rat Allergy Original Suppressive effects of bifidobacterium Inoue, Yumi; Iwabuchi, Noriyuki; Biological & 2009 10.1248/bpb.32.760 article breve strain M-16V on T-helper type 2 Xiao, Jin-Zhong; Yaeshima, pharmaceutica immune responses in a murine model Tomoko; Iwatsuki, Keiji l bulletin 21* M-16V Infant Preterm Original Effects of oral administration of Wang, Chongxin; Shoji, Hiromichi; Journal of 2007 10.1097/01.mpg.0000252 article bifidobacterium breve on fecal lactic acid Sato, Hiroaki; Nagata, Satoru; pediatric 184.89922.5f and short-chain fatty acids in low birth Ohtsuka, Yoshikazu; Shimizu, gastroenterolo weight infants Toshiaki; Yamashiro, Yuichiro gy and nutrition 22* M-16V Infant Allergy Original Administration of Bifidobacterium to Taniuchi, Shoichiro; Hattori, Journal of 2005 - article infants with atopic dermatitis: Changes Kazuhiro; Yamamoto, Akemi; Applied in fecal microflora and clinical Sasai, Misa; Hatano, Yasuko; Research symptoms Kojima, Takatsugu; Kobayashi, Yohnosuke; Iwamoto, Hiroshi; Yaeshima, Tomoko

No. Inter- Study Target Article Title Authors Publisher Year DOI vention model/ subject 23* M-16V Infant Allergy Original Effects of administration of Hattori, Kazuhiro; Yamamoto, Arerugi = 2003 - article bifidobacteria on fecal microflora and Akemi; Sasai, Misa; Taniuchi, [Allergy] clinical symptoms in infants with atopic Shoichiro; Kojima, Takatsugu; dermatitis Kobayashi, Yohnosuke; Iwamoto, Hiroshi; Namba, Kyoko; Yaeshima, Tomoko 24* M-16V In vitro Safety Original Probiotic characteristics and in vitro Marco Toscano & Elena De Vecchi Annals of 2015 10.1007/s13213-014-0953- article compatibility & Arianna Gabrieli & Microbiology 5 of a combination of Bifidobacterium Gian Vincenzo Zuccotti & Lorenzo breve M-16 V, Drago Bifidobacterium longum subsp. infantis M-63 and Bifidobacterium longum subsp. longum BB536 25* M-16V Mice Immune Original Immunobiotic Lactobacillus jensenii Shimazu T, Villena J, Tohno M, Infect Immun. 2012 10.1128/IAI.05729-11 article elicits anti-inflammatory activity in Fujie H, Hosoya S, Shimosato T, porcine intestinal epithelial cells by Aso H, Suda Y, Kawai Y, Saito T, modulating negative regulators of the Makino S, Ikegami S, Itoh H, Toll-like receptor signaling pathway. Kitazawa H. 26* M-16V In vitro Safety Original Antibiotic susceptibility of Xiao JZ, Takahashi S, Odamaki T, Biosci 2010 10.1271/bbb.90659 article bifidobacterial strains distributed in the Yaeshima T, Iwatsuki K. Biotechnol Japanese market Biochem. 27 M-16V Infant Preterm Original Probiotic Supplementation Dramatically Hiroaki Sato, Masaki Daigo, Juntendo 2009 10.14789/pjmj.55.136 article Decreases Infection Deaths in Extremely Kazuhiro Ohzeki, Hikaru Medical and Very Low Birth Weight Infants Umezaki, Ayako Kudo, Yuichiro Journal Yamashiro 28* M-16V Rat Safety Original Safety Evaluation of Two Probiotic Fumiaki Abe, Tomoko Yaeshima, Bioscience and 2009 10.12938/bifidus.28.7 article Bifidobacterial Strains, Bifidobacterium Keiji Iwatsuki Microflora breve M-16V and Bifidobacterium infantis M-63, by Oral Toxicity Tests Using Rats 29* M-16V In vitro Stability Original Stability of bifidobacteria in powdered Fumiaki Abe Hirofumi Miyauchi International 2009 10.1111/j.1365- article formula Ayako Uchijima Tomoko Journal of 2621.2008.01881.x Yaeshima Keiji Iwatsuki Food Science and Technology No. Inter- Study Target Article Title Authors Publisher Year DOI vention model/ subject 30* M-16V Infant Preterm Original Bifidobacterium breve enhances Fujii T, Ohtsuka Y, Lee T, Kudo T, J Pediatr 2006 10.1097/01.mpg.0000228 article transforming growth factor beta1 Shoji H, Sato H, Nagata S, Shimizu Gastroenterol 100.04702.f8 signaling by regulating Smad7 T, Yamashiro Y. Nutr. expression in preterm infants 31* M-16V Infant Preterm Original Effects of bifidobacterium breve Li Y, Shimizu T, Hosaka A, Kaneko Pediatr Int. 2004 10.1111/j.1442- article supplementation on intestinal flora of N, Ohtsuka Y, Yamashiro Y. 200x.2004.01953.x low birth weight infants 32* M-16V/ Infant Preterm Original Effect of administration of bifidobacteria Ishizeki, Shinobu; Sugita, Masaoki; Anaerobe 2013 10.1016/j.anaerobe.2013. Probiotics article on intestinal microbiota in low-birth- Takata, Masaaki; Yaeshima, 08.002 mixture weight infants and transition of Tomoko administered bifidobacteria: a comparison between one-species and three-species administration 33 Probiotics Elderly Cognitive Original Effect of combined bifidobacteria Inoue, T; Kobayashi, Y; Mori, N; Beneficial 2018 10.3920/BM2017.0193 mixture function article supplementation and resistance training Sakagawa, M; Xiao, J-Z; Moritani, microbes on cognitive function, body composition T; Sakane, N; Nagai, N and bowel habits of healthy elderly subjects 34* Probiotics Children Allergy Original Bifidobacterium mixture (B longum Miraglia Del Giudice, Michele; Italian journal 2017 10.1186/s13052-017-0340- mixture article BB536, B infantis M-63, B breve M-16V) Indolfi, Cristiana; Capasso, of pediatrics 5 treatment in children with seasonal Michele; Maiello, Nunzia; Decimo, allergic rhinitis and intermittent asthma Fabio; Ciprandi, Giorgio 35 Probiotics Children Abdominal Original A Mixture of 3 Bifidobacteria Decreases Giannetti, Eleonora; Maglione, Journal of 2017 10.1097/MCG.000000000 mixture pain & QOL article Abdominal Pain and Improves the Marco; Alessandrella, Annalisa; clinical 0000528 Quality of Life in Children With Irritable Strisciuglio, Caterina; De Giovanni, gastroenterolo Bowel Syndrome: A Multicenter, Donatella; Campanozzi, Angelo; gy Randomized, Double-Blind, Placebo- Miele, Erasmo; Staiano, Annamaria Controlled, Crossover Trial 36* Probiotics Infant Allergy Original Effects of bifidobacterial Enomoto, Tadao; Sowa, Masanori; Allergology 2014 10.2332/allergolint.13- mixture article supplementation to pregnant women Nishimori, Keiji; Shimazu, international : OA-0683 and infants in the prevention of allergy Shinichiro; Yoshida, Akira; official journal development in infants and on fecal Yamada, Kazuko; Furukawa, of the microbiota Fukumi; Nakagawa, Takemasa; Japanese Yanagisawa, Naotake; Iwabuchi, Society of Noriyuki; Odamaki, Toshitaka; Allergology Abe, Fumiaki; Nakayama, Jiro; Xiao, Jin-Zhong No. Inter- Study Target Article Title Authors Publisher Year DOI vention model/ subject 37 Synbiotics Infant Allergy Original A specific synbiotic-containing amino Wopereis, Harm; van Ampting, Clinical and 2019 10.1186/s13601-019-0267- article acid-based formula restores gut Marleen T J; Cetinyurek-Yavuz, translational 6 microbiota in non-IgE mediated cow's Aysun; Slump, Rob; Candy, David allergy milk allergic infants: a randomized C A; Butt, Assad M; Peroni, Diego controlled trial G; Vandenplas, Yvan; Fox, Adam T; Shah, Neil; Roeselers, Guus; Harthoorn, Lucien F; Michaelis, Louise J; Knol, Jan; West, Christina E 38 Synbiotics Rat Immune Original The Combination of Bifidobacterium Izumi, Hirohisa; Ehara, Tatsuya; The Journal of 2019 10.1093/jn/nxy248 article breve and Three Prebiotic Sugahara, Hirosuke; Matsubara, nutrition Oligosaccharides Modifies Gut Immune Takeshi; Mitsuyama, Eri; and Endocrine Functions in Neonatal Nakazato, Yuki; Tsuda, Muneya; Mice Shimizu, Takashi; Odamaki, Toshitaka; Xiao, Jin-Zhong; Takeda, Yasuhiro 39 Synbiotics Infant Allergy Original A specific synbiotic-containing amino Fox, Adam T; Wopereis, Harm; Clinical and 2019 10.1186/s13601-019-0241- article acid-based formula in dietary Van Ampting, Marleen T J; Oude translational 3 management of cow's milk allergy: a Nijhuis, Manon M; Butt, Assad M; allergy randomized controlled trial Peroni, Diego G; Vandenplas, Yvan; Candy, David C A; Shah, Neil; West, Christina E; Garssen, Johan; Harthoorn, Lucien F; Knol, Jan; Michaelis, Louise J 40 Synbiotics Mice Obesity Original Specific synbiotics in early life protect Mona Mischke, Tulika Arora, Diabetes 2018 10.1111/dom.13240 article against diet-induced obesity in adult Sebastian Tims, Eefje Engels, Obesity & mice Nina Sommer, Kees van Limpt, Metabolism Annemarie Baars, Raish Oozeer, Annemarie Oosting, Fredrik Bäckhed, Jan Knol 41 Synbiotics Infant Preterm Original Outcomes in preterm small versus Athalye-Jape, Gayatri; Minaee, J Matern Fetal 2018 10.1080/14767058.2018.1 article appropriate for gestation infants after Novia; Nathan, Elizabeth; Simmer, Neonatal Med 543657 Bifidobacterium breve M-16 V Karen; Patole, Sanjay supplementation

No. Inter- Study Target Article Title Authors Publisher Year DOI vention model/ subject 42 Synbiotics Children Microbiota Original A synbiotic mixture of scGOS/lcFOS and Kosuwon, P; Lao-Araya, M; Beneficial 2018 10.3920/BM2017.0110 article Bifidobacterium breve M-16V increases Uthaisangsook, S; Lay, C; Bindels, microbes faecal Bifidobacterium in healthy young J; Knol, J; Chatchatee, P children 43 Synbiotics Mice Rotavirus Original Preventive Effect of a Synbiotic Rigo-Adrover, Maria Del Mar; van Frontiers in 2018 10.3389/fimmu.2018.013 infections article Combination of Galacto- and Limpt, Kees; Knipping, Karen; immunology 18 Fructooligosaccharides Mixture With Garssen, Johan; Knol, Jan; Bifidobacterium breve M-16V in a Model Costabile, Adele; Franch, Àngels; of Multiple Rotavirus Infections Castell, Margarida; Pérez-Cano, Francisco José 44 Synbiotics Infant Allergy Original A synbiotic-containing amino-acid- Candy, David C A; Van Ampting, Pediatric 2017 10.1038/pr.2017.270 article based formula improves gut microbiota Marleen T J; Oude Nijhuis, Manon research in non-IgE-mediated allergic infants M; Wopereis, Harm; Butt, Assad M; Peroni, Diego G; Vandenplas, Yvan; Fox, Adam T; Shah, Neil; West, Christina E; Garssen, Johan; Harthoorn, Lucien F; Knol, Jan; Michaelis, Louise J 45 Synbiotics Mice Allergy Original Dietary, nondigestible oligosaccharides de Kivit, Sander; Kostadinova, Journal of 2017 10.1189/jlb.3A0516-236R article and Bifidobacterium breve M-16V Atanaska I; Kerperien, JoAnn; leukocyte suppress allergic inflammation in Morgan, Mary E; Muruzabal, biology intestine via targeting dendritic cell Veronica Ayechu; Hofman, Gerard maturation A; Knippels, Leon M J; Kraneveld, Aletta D; Garssen, Johan; Willemsen, Linette E M 46 Synbiotics Infant Microbiota Original Effect of Synbiotic on the Gut Microbiota Chua, Mei Chin; Ben-Amor, Journal of 2017 10.1097/MPG.000000000 article of Cesarean Delivered Infants: A Kaouther; Lay, Christophe; Neo, pediatric 0001623 Randomized, Double-blind, Multicenter Anne G E; Chiang, Wei Chin; Rao, gastroenterolo Study Rajeshwar; Chew, Charmaine; gy and Chaithongwongwatthana, nutrition Surasith; Khemapech, Nipon; Knol, Jan; Chongsrisawat, Voranush 47 Synbiotics Rat Rotavirus Original A combination of scGOS/lcFOS with Rigo-Adrover, M; Saldaña-Ruíz, S; European 2017 10.1007/s00394-016-1213- infections article Bifidobacterium breve M-16V protects van Limpt, K; Knipping, K; journal of 1 suckling rats from rotavirus Garssen, J; Knol, J; Franch, A; nutrition gastroenteritis Castell, M; Pérez-Cano, F J No. Inter- Study Target Article Title Authors Publisher Year DOI vention model/ subject 48 Synbiotics Mice Allergy Original A Specific Mixture of Fructo- Kostadinova, Atanaska I; Frontiers in 2017 10.3389/fimmu.2016.006 article Oligosaccharides and Bifidobacterium Meulenbroek, Laura A P M; van immunology 73 breve M-16V Facilitates Partial Non- Esch, Betty C A M; Hofman, Responsiveness to Whey Protein in Mice Gerard A; Garssen, Johan; Orally Exposed to β-Lactoglobulin- Willemsen, Linette E M; Knippels, Derived Peptides Léon M J 49 Synbiotics Infant Growth Original Infant formula containing galacto-and Abrahamse-Berkeveld, M; Alles, Journal of 2016 10.1017/jns.2016.35 article fructo-oligosaccharides and M; Franke-Beckmann, E; Helm, K; nutritional Bifidobacterium breve M-16V supports Knecht, R; Köllges, R; Sandner, B; science adequate growth and tolerance in Knol, J; Ben Amor, K; Bufe, A healthy infants in a randomised, controlled, double-blind, prospective, multicentre study 50 Synbiotics Mice Allergy Original Post-sensitization administration of non- van Esch, Betty C A M; Abbring, Immunity, 2016 10.1002/iid3.101 article digestible oligosaccharides and Suzanne; Diks, Mara A P; Dingjan, inflammation Bifidobacterium breve M-16V reduces Gemma M; Harthoorn, Lucien F; and disease allergic symptoms in mice Vos, A Paul; Garssen, Johan 51 Synbiotics Mice Allergy Original The development of allergic Verheijden, K A T; Willemsen, L E European 2016 10.1007/s00394-015-0928- article inflammation in a murine house dust M; Braber, S; Leusink-Muis, T; journal of 8 mite asthma model is suppressed by Jeurink, P V; Garssen, J; Kraneveld, nutrition synbiotic mixtures of non-digestible A D; Folkerts, G oligosaccharides and Bifidobacterium breve M-16V 52 Synbiotics Infant Allergy Original Synbiotics-supplemented amino acid- Burks, A Wesley; Harthoorn, Pediatric 2015 10.1111/pai.12390 article based formula supports adequate Lucien F; Van Ampting, Marleen T allergy and growth in cow's milk allergic infants J; Oude Nijhuis, Manon M; immunology Langford, Jane E; Wopereis, Harm; Goldberg, Steven B; Ong, Peck Y; Essink, Brandon J; Scott, Robert B; Harvey, Bryan M 53 Synbiotics Human Allergy Original Novel immunotherapy approaches to Hayen, Simone M; Kostadinova, Current 2014 10.1097/ACI.0000000000 article food allergy Atanaska I; Garssen, Johan; Otten, opinion in 000109 Henny G; Willemsen, Linette E M allergy and clinical immunology No. Inter- Study Target Article Title Authors Publisher Year DOI vention model/ subject 54 Synbiotics Infant Allergy Original Intestinal epithelium-derived galectin-9 de Kivit, Sander; Kraneveld, Aletta Journal of 2013 10.1159/000350515 article is involved in the immunomodulating D; Knippels, Leon M J; van Kooyk, innate effects of nondigestible oligosaccharides Yvette; Garssen, Johan; Willemsen, immunity Linette E M 55* Synbiotics Infant Allergy Original No detectable beneficial systemic van der Aa, L B; Lutter, R; Clinical and 2012 10.1111/j.1365- article immunomodulatory effects of a specific Heymans, H S A; Smids, B S; experimental 2222.2011.03890.x synbiotic mixture in infants with atopic Dekker, T; van Aalderen, W M C; allergy dermatitis Sillevis Smitt, J H; Knippels, L M J; Garssen, J; Nauta, A J; Sprikkelman, A B 56 Synbiotics Human/ Allergy Original Galectin-9 induced by dietary synbiotics de Kivit, S; Saeland, E; Kraneveld, Allergy 2012 10.1111/j.1398- Rat article is involved in suppression of allergic A D; van de Kant, H J G; Schouten, 9995.2011.02771.x symptoms in mice and humans B; van Esch, B C A M; Knol, J; Sprikkelman, A B; van der Aa, L B; Knippels, L M J; Garssen, J; van Kooyk, Y; Willemsen, L E M 57* Synbiotics Infant Allergy Original Synbiotics prevent asthma-like van der Aa, L B; van Aalderen, W Allergy 2011 10.1111/j.1398- article symptoms in infants with atopic M C; Heymans, H S A; Henk 9995.2010.02416.x dermatitis Sillevis Smitt, J; Nauta, A J; Knippels, L M J; Ben Amor, K; Sprikkelman, A B 58 Synbiotics Adult Allergy Original Synbiotics reduce allergen-induced T- van de Pol, M A; Lutter, R; Smids, Allergy 2011 10.1111/j.1398- article helper 2 response and improve peak B S; Weersink, E J M; van der Zee, J 9995.2010.02454.x expiratory flow in allergic asthmatics S 59 Synbiotics Infant Allergy Original Effect of a new synbiotic mixture on van der Aa, L B; Heymans, H S; Clinical and 2010 10.1111/j.1365- article atopic dermatitis in infants: a van Aalderen, W M; Sillevis Smitt, experimental 2222.2010.03465.x randomized-controlled trial J H; Knol, J; Ben Amor, K; allergy Goossens, D A; Sprikkelman, A B 60 Synbiotics Mice Allergy Original Cow milk allergy symptoms are reduced Schouten, Bastiaan; van Esch, Betty The Journal of 2009 10.3945/jn.109.108514 article in mice fed dietary synbiotics during C A M; Hofman, Gerard A; van nutrition oral sensitization with whey Doorn, Suzan A C M; Knol, Jan; Nauta, Alma J; Garssen, Johan; Willemsen, Linette E M; Knippels, Léon M J

No. Inter- Study Target Article Title Authors Publisher Year DOI vention model/ subject Additional articles not deposited in database 61* M-16V Infant Microbiota Original Effects of oral administration of Akiyama, K.; Hosono, S.; Acta Neonatol 1994 - article Bifidobacterium breve on development Takahashi, E.; Ishizeki, S.; Japonica of intestinal microflora in extremely Takigawa, I.; Imura, S.; Yamauchi, premature infants. K.; Yaeshima, T.; Hayasawa, H.; Shimamura, S. 62* B. longum Infant Microbiota Original Effects of administration of Akiyama, K.; Shimada, M.; Acta Neonatol 1994 - BB536 article Bifidobacterium in extremely premature Ishizeki, S.; Takigawa, I.; Imura, S.; Japonica (compare infants. Development of intestinal Yamauchi, K.; Hatano, M.; Abe, N.; with M- microflora by orally administered Yaeshima, T.; Hayasawa, H. 16V) Bifidobacterium longum (in comparison with Bifidobacterium breve) 63* M-16V In vitro Immune Original Transforming growth factor-β: an Ohtsuka, Y.; Sanderson, I.R. Curr Opin 2000 https://www.ncbi.nlm.ni article important cytokine in the mucosal Gastroenterol h.gov/pubmed/17031135 immune response. 64* M-16V Infant Preterm Original Bifidobacteria prevents necrotizing Satoh, Y.; Shinohara, K.; Umezaki, Int J Probiotics 2007 http://www.nchpjournal article enterocolitis and infection in preterm H.; Shoji, H.; Satoh, H.; Ohtsuka, Prebiotics s.com/manuscript/uploa infants. Y.; Shiga, S.; Nagata, S.; Shimizu, ds/article_727.pdf T.; Yamashiro, Y. *Article numbers with asterisk were selected and included in this review.