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The proteome of pus from human brain abscesses: host-derived neurotoxic proteins and the cell-type diversity of CNS pus B. Hassel et al. https://thejns.org/doi/abs/10.3171/2017.4.JNS17284

DISCLAIMER The Journal of Neurosurgery acknowledges that the following section is published verbatim as submitted by the authors and did not go through either the Journal’s peer-review or editing process.

©AANS, 2017 J Neurosurg Supplemental Table 1: 1379 proteins in extracellular fluid of brain abscess pus, arranged according to abundance and alphabetically. Proteins from the extracellular phase of pus from 20 brain abscesses were analyzed by mass spectrometry. Data are log-10 (mean and SD values) transformations of raw data from the mass spectrometry analysis. Values are calculated from the samples in which a protein was detected; the number of positive samples are given in the column "N". To the left proteins are listed according to their abundance; to the right they are listed alphabetically.

Abundance Alphabetically

Protein Mean SD N Protein Mean SD N

Protein S100-A9 11.5 0.3 20 Acetyl-CoA acetyltransferase, cytosolic 6.9 0.4 3 Hemoglobin subunit alpha (HBA1) 11.5 0.3 20 Acetyl-CoA acetyltransferase, mitochondrial 6.6 0.5 5 Hemoglobin subunit beta 11.4 0.3 20 Acetyl-CoA carboxylase 1/Biotin carboxylase 8.1 1 Serum albumin 11.4 0.4 20 Acid ceramidase 7.8 0.5 20 Protein S100-A8 10.8 0.2 20 Acidic leucine-rich nuclear phosphoprotein 32 family member A 8.0 0.5 15 Myeloperoxidase 10.8 0.3 20 Acidic leucine-rich nuclear phosphoprotein 32 family member B 7.9 0.8 16 Alpha-2-macroglobulin 10.6 0.3 20 Acidic leucine-rich nuclear phosphoprotein 32 family member E 7.3 0.2 5 Lactotransferrin 10.5 0.3 20 Aconitate hydratase, mitochondrial 7.1 0.9 6 Plastin-2 10.5 0.3 20 Actin, alpha skeletal muscle 9.4 0.5 19 Ig gamma-1 chain C region 10.5 0.3 20 Actin, cytoplasmic 1 10.4 0.4 20 Alpha-1-acid glycoprotein 1 10.4 0.5 20 Actin, gamma1 7.6 0.5 15 dNA primase large subunit 10.4 0.3 20 Actin-related protein 2 8.7 0.6 20 Actin, cytoplasmic 1 10.4 0.4 20 Actin-related protein 2/3 complex subunit 1B 8.0 0.7 20 Complement C3 10.3 0.4 20 Actin-related protein 2/3 complex subunit 2 8.9 0.5 20 Catalase 10.2 0.3 20 Actin-related protein 2/3 complex subunit 3 8.4 0.6 20 Alpha-1-antitrypsin 10.2 0.4 20 Actin-related protein 2/3 complex subunit 4 8.6 0.5 19 Myosin-9 10.2 0.4 20 Actin-related protein 2/3 complex subunit 5 8.1 0.7 20 Transthyretin 10.2 0.4 20 Actin-related protein 3 8.7 0.5 20 Histone H2B 10.1 0.6 20 Activated RNA polymerase II transcriptional coactivator p15 7.9 0.2 4 Serotransferrin 10.1 0.6 20 Acylamino-acid-releasing enzyme 8.5 0.4 20 Haptoglobin 10.1 0.4 20 Acyl-CoA-binding protein 8.3 0.5 20 Alpha-actinin-1 10.1 0.4 20 Acylphosphatase-2 5.7 0.3 3 Ig lambda-1 chain C regions 10.0 0.3 20 Acyl-protein thioesterase 1 7.1 0.6 17 Ig alpha-1 chain C region 10.0 0.5 20 Adenine phosphoribosyltransferase 6.9 0.4 16 Neutrophil gelatinase-associated lipocalin 9.9 0.3 20 Adenosine deaminase 8.1 0.3 20 Histone H4 9.9 0.9 20 Adenosine kinase 7.4 0.5 16 Hemoglobin subunit delta 9.9 0.4 20 Adenosylhomocysteinase 8.7 0.4 19 Vimentin 9.8 0.4 20 Adenylate kinase 2, mitochondrial 8.1 0.6 20 Glucose-6-phosphate isomerase 9.8 0.5 20 Adenylate kinase isoenzyme 1 7.8 0.7 18 Transketolase 9.8 0.4 20 Adenylosuccinate lyase 7.2 0.5 16 Filamin-A 9.8 0.3 20 Adenylosuccinate synthetase isozyme 2 7.7 0.6 12 Ig kappa chain V-III region SIE 9.8 0.3 20 Adenylyl cyclase-associated protein 1 9.5 0.4 20 Myeloblastin 9.7 0.4 20 Adipocyte plasma membrane-associated protein 7.7 1.0 19 Leukocyte elastase inhibitor 9.7 0.3 20 Adiponectin 6.9 0.4 9 Ferritin heavy chain 9.7 0.3 20 ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 2 8.4 0.6 20 Triosephosphate isomerase 9.7 0.5 20 ADP-ribosylation factor 1/3 8.0 0.6 18 Protein S100-A12 9.7 0.7 20 ADP-ribosylation factor-like protein 8B 7.4 0.3 8 Hemopexin 9.7 0.5 20 ADP-sugar pyrophosphatase 7.4 0.4 13 Haptoglobin-related protein 9.7 0.4 20 Afamin 8.1 0.8 19 Ferritin light chain 9.7 0.4 20 Aflatoxin B1 aldehyde reductase member 2 8.1 0.6 20 Glyceraldehyde-3-phosphate dehydrogenase 9.6 0.9 20 Agrin 7.8 0.8 2 Histone H2A type 1-J 9.6 0.5 20 Alcohol dehydrogenase [NADP+] 7.4 0.5 16 Cystatin-A 9.6 0.3 20 Aldehyde dehydrogenase family 16 member A1 7.8 0.5 13 Complement C4-B 9.6 0.5 20 Aldehyde dehydrogenase, mitochondrial 7.3 0.9 7 Transaldolase 9.6 0.3 20 Alkaline phosphatase, tissue-nonspecific isozyme 6.8 0.3 3 Azurocidin 9.5 0.4 20 Allograft inflammatory factor 1 7.6 0.7 20 Fibrinogen beta chain 9.5 0.7 20 Alpha/beta-soluble NSF attachment protein 6.8 0.2 4 Alpha-enolase 9.5 0.6 20 Alpha-1-acid glycoprotein 1 10.4 0.5 20 Gelsolin 9.5 0.4 20 Alpha-1-acid glycoprotein 2 9.4 0.5 20 Adenylyl cyclase-associated protein 1 9.5 0.4 20 Alpha-1-antichymotrypsin 8.5 0.5 20 Histone H3 9.5 0.4 20 Alpha-1-antitrypsin 10.2 0.4 20 Calmodulin 9.5 0.3 20 Alpha-1B-glycoprotein 9.4 0.3 20 Vinculin 9.5 0.3 20 Alpha-2-antiplasmin 8.5 0.4 20 Zinc-alpha-2-glycoprotein 9.5 0.5 20 Alpha-2-HS-glycoprotein 7.7 0.8 20 Fructose-bisphosphate aldolase A 9.5 0.3 20 Alpha-2-macroglobulin 10.6 0.3 20 Ubiquitin-60S ribosomal protein L40 9.5 0.3 20 Alpha-actinin-1 10.1 0.4 20 Profilin-1 9.5 0.6 20 Alpha-actinin-4 9.4 0.4 20 Hemoglobin subunit alpha (HBA2) 9.4 0.8 20 Alpha-adducin 7.3 0.6 15 14-3-3 protein z/d 9.4 0.5 20 Alpha-centractin 7.4 0.5 7 Ceruloplasmin 9.4 0.5 20 Alpha-crystallin B chain 7.2 0.6 5 Ig lambda-2 chain C regions 9.4 0.3 20 Alpha-endosulfine 6.5 0.7 11 Alpha-1B-glycoprotein 9.4 0.3 20 Alpha-enolase 9.5 0.6 20 Moesin 9.4 0.4 20 Alpha-hemoglobin-stabilizing protein 6.5 0.7 4 Alpha-actinin-4 9.4 0.4 20 Alpha-internexin 6.9 0.5 7 Ig kappa chain V-I region WEA 9.4 0.3 20 Alpha-synuclein 6.3 0.7 5 DNA primase large subunit 9.4 0.4 20 Aminopeptidase B 7.5 0.5 13 Alpha-1-acid glycoprotein 2 9.4 0.5 20 Aminopeptidase N 8.9 0.6 20 Protein S100-P 9.4 0.3 20 AMP deaminase 3 7.4 0.5 9 Talin-1 9.4 0.4 20 Amyloid beta A4 precursor protein-binding L-lactate dehydrogenase A chain 9.3 0.6 20 family B member 1-interacting protein 7.3 0.8 12 Apolipoprotein B-100 9.3 0.7 20 Amyloid beta A4 protein 6.4 0.4 7 Coronin-1A 9.3 0.3 20 Angiotensinogen/Angiotensin 8.1 0.9 18 Annexin A1 9.3 0.9 20 Ankyrin repeat domain-containing protein 36A/B 6.2 0.5 11 Apolipoprotein A-I 9.3 1.1 20 Ankyrin-1 7.6 0.7 16 Annexin A3 9.3 0.7 20 Annexin A1 9.3 0.9 20 6-phosphogluconate dehydrogenase 9.3 0.5 20 Annexin A11 8.2 0.7 19 Ig gamma-2 chain C region 9.3 0.5 20 Annexin A2 7.7 0.7 13 Ig kappa chain V-IV region Len 9.3 0.3 20 Annexin A3 9.3 0.7 20 Myosin light polypeptide 6 9.3 0.5 20 Annexin A4 8.0 0.9 20 Matrix metalloproteinase-9 9.3 0.6 20 Annexin A5 8.7 0.9 19 Carcinoembryonic antigen-related cell adhesion molecule 8 9.2 0.5 20 Annexin A6 8.7 0.8 20 Phosphoglycerate kinase 1 9.2 0.6 20 Annexin A7 7.7 0.6 17 Serpin B10 9.2 0.4 20 Anterior gradient protein 2 homolog 7.6 1 Thioredoxin 9.2 0.4 20 Antithrombin-III 9.1 0.4 20 Heat shock 70 kDa protein 1A/1B 9.2 0.6 20 AP-1 complex subunit beta-1 7.1 0.4 12 Purine nucleoside phosphorylase 9.2 0.6 20 AP-2 complex subunit a-1/2 6.8 0.2 2 Ig mu chain C region 9.2 0.5 20 AP-2 complex subunit b 7.7 0.5 15 Ig kappa chain V-II region GM607 9.2 0.6 20 AP-2 complex subunit m 7.4 1 Superoxide dismutase [Mn], mitochondrial 9.2 0.5 20 Apolipoprotein A-I 9.3 1.1 20 Ras GTPase-activating-like protein IQGAP1 9.2 0.4 20 Apolipoprotein A-II 7.8 0.9 20 Peptidyl-prolyl cis-trans isomerase A 9.1 0.7 20 Apolipoprotein A-IV 7.7 0.8 19 Fibrinogen gamma chain 9.1 0.7 20 Apolipoprotein B receptor 7.6 0.5 20 Neutrophil collagenase 9.1 0.4 20 Apolipoprotein B-100 9.3 0.7 20 Plasma protease C1 inhibitor 9.1 0.7 20 Apolipoprotein C-I 8.2 0.7 16 Pyruvate kinase (PKM3) 9.1 0.5 20 Apolipoprotein C-II 7.3 0.9 19 Spectrin alpha chain, non-erythrocytic 1 9.1 0.5 20 Apolipoprotein C-III 7.7 0.8 15 Antithrombin-III 9.1 0.4 20 Apolipoprotein D 8.6 0.5 20 Fibronectin 9.1 0.5 20 Apolipoprotein E 8.2 0.9 19 Glycogen phosphorylase, liver form 9.1 0.5 20 Apolipoprotein F 7.4 0.6 3 Cathepsin G 9.0 0.6 20 Apolipoprotein L1 6.9 1.1 14 Fibrinogen a chain 9.0 0.6 20 Apolipoprotein M 7.3 0.5 17 Carbonic anhydrase 1 9.0 0.6 20 Apolipoprotein A 7.0 0.5 9 Leukotriene A-4 hydrolase 9.0 0.5 20 Apoptosis inhibitor 5 7.4 0.4 10 Maltase-glucoamylase, intestinal 9.0 0.4 20 Apoptosis-associated speck-like protein containing a CARD 8.6 0.6 20 Bactericidal permeability-increasing protein 9.0 0.7 20 Arachidonate 5-lipoxygenase 7.5 0.9 12 Peroxiredoxin-2 9.0 0.7 20 Arginase-1 9.0 0.5 20 Phosphoglycerate mutase 1 9.0 0.5 20 Argininosuccinate lyase 7.6 0.6 19 Arginase-1 9.0 0.5 20 Arylsulfatase A 7.5 0.4 16 Lysosome-associated membrane glycoprotein 2 9.0 0.5 20 Arylsulfatase B 7.1 0.4 17 Proteasome subunit a type-7 9.0 0.4 20 Aspartate aminotransferase, cytoplasmic 8.3 0.4 20 Protein S100-A4 9.0 0.4 20 Aspartate aminotransferase, mitochondrial 8.0 0.4 20 Myosin regulatory light chain 12A 9.0 0.7 20 Aspartyl aminopeptidase 7.4 0.3 5 Phospholipase B-like 1 9.0 0.4 20 ATP synthase subunit alpha, mitochondrial 7.3 0.9 14 Ig heavy chain V-III region BRO 8.9 0.3 20 ATP synthase subunit beta, mitochondrial 7.4 1.1 10 Proteasome subunit a type-1 8.9 0.4 20 ATP synthase subunit d, mitochondrial 7.4 0.6 3 Heat shock cognate 71 kDa protein 8.9 0.5 20 ATP synthase subunit f, mitochondrial 6.7 1.1 2 Nucleophosmin 8.9 0.4 20 ATP synthase subunit O, mitochondrial 7.5 0.3 3 Proteasome subunit alpha type-5 8.9 0.5 20 ATPase ASNA1 7.3 0.1 3 Actin-related protein 2/3 complex subunit 2 8.9 0.5 20 ATP-binding cassette sub-family B member 6, mitochondrial 6.5 0.6 5 Proteasome subunit beta type-1 8.9 0.4 20 ATP-binding cassette sub-family B member 9 7.9 0.4 17 Lysozyme C 8.9 0.4 20 ATP-binding cassette sub-family F member 1 5.8 0.2 2 Vasodilator-stimulated phosphoprotein 8.9 0.6 20 ATP-citrate synthase 7.4 0.5 15 Leucine-rich alpha-2-glycoprotein 8.9 0.5 20 ATP-dependent dihydroxyacetone kinase/FAD-AMP lyase 7.6 0.8 16 Protein S100-A11 8.9 0.5 20 ATP-dependent RNA helicase DDX39A 6.7 0.9 8 Malate dehydrogenase, cytoplasmic 8.9 0.6 20 ATP-dependent RNA helicase DDX3X 7.3 0.6 9 Aminopeptidase N 8.9 0.6 20 Attractin 7.8 0.3 14 Ig lambda variable 3-21 8.9 0.3 20 Azurocidin 9.5 0.4 20 Ig kappa chain V-I region EU 8.8 0.3 20 Bactericidal permeability-increasing protein 9.0 0.7 20 Protein S100-A6 8.8 0.4 20 Band 3 anion transport protein 8.2 1.0 18 Glutathione S-transferase omega-1 8.8 0.5 20 Barrier-to-autointegration factor 7.4 0.4 13 Eosinophil cationic protein 8.8 0.5 20 Beta-2-glycoprotein 1 6.9 0.8 11 Ig lambda chain V-I region WAH 8.8 0.4 20 Beta-2-microglobulin 6.4 0.5 4 Proteasome subunit alpha type-2 8.8 0.6 20 Beta-actin-like protein 2 7.6 0.2 7 Proteasome subunit b type-2 8.8 0.6 20 Beta-adducin 7.2 0.6 3 Carcinoembryonic antigen-related cell adhesion molecule 6 8.8 0.5 20 Beta-Ala-His dipeptidase 7.3 0.3 7 78 kDa glucose-regulated protein 8.8 0.6 20 Beta-centractin 6.9 0.2 2 Complement factor B 8.8 0.5 20 Beta-glucuronidase 8.2 0.5 20 Ig kappa chain V-III region NG9 8.8 0.6 20 Beta-hexosaminidase 7.9 0.7 19 14-3-3 protein epsilon 8.8 0.4 20 Beta-hexosaminidase subunit b 8.2 0.3 19 Rho GDP-dissociation inhibitor 2 8.8 0.5 20 Beta-mannosidase 7.4 1 Peroxiredoxin-6 8.8 0.7 20 BH3-interacting domain death agonist 7.2 0.6 13 Non-secretory ribonuclease 8.8 0.5 20 Bifunctional purine biosynthesis protein PURH 7.2 0.6 12 Glutathione reductase, mitochondrial 8.7 0.5 20 Biliverdin reductase A 7.1 0.5 2 Resistin 8.7 0.5 20 Biotinidase 7.1 0.4 8 Actin-related protein 2 8.7 0.6 20 Bisphosphoglycerate mutase 7.3 0.6 17 SH3 domain-binding glutamic acid-rich-like protein 3 8.7 0.4 20 Bleomycin hydrolase 7.9 0.4 19 Ig heavy chain V-III region TIL 8.7 0.4 20 Blood group Rh(D/C/E) polypeptide 6.5 0.3 2 Heat shock protein HSP 90-alpha 8.7 0.5 20 Bradykinin 7.8 1.0 18 Hemoglobin subunit gamma-1 8.7 0.7 20 Brain acid soluble protein 1 8.0 0.6 20 F-actin-capping protein subunit b 8.7 0.6 20 Bridging integrator 2 7.8 0.5 19 Ig gamma-3 chain C region 8.7 0.3 20 BTB/POZ domain-containing protein KCTD12 7.7 0.4 18 Lamin-B1 8.7 0.5 20 C4b-binding protein alpha chain 8.3 0.4 20 Ig lambda chain V-IV region Hil 8.7 0.4 20 C4b-binding protein beta chain 7.3 0.8 14 Actin-related protein 3 8.7 0.5 20 Cadherin-1 8.3 1 Macrophage-capping protein 8.7 0.4 20 Cadherin-13 5.8 1 Neutrophil elastase 8.7 0.6 20 Cadherin-5 7.1 0.0 3 Annexin A6 8.7 0.8 20 Calbindin 7.5 1.0 5 Ig kappa chain V-I region Ni 8.7 0.3 20 Calcineurin B homologous protein 1 6.9 0.6 16 Protein SET 8.7 0.5 20 Calcineurin subunit B type 1 7.3 0.5 9 SH3 domain-binding glutamic acid-rich-like protein 8.6 0.3 20 Calcium uniporter protein, mitochondrial 7.3 0.3 4 Fructose-bisphosphate aldolase C 8.6 0.4 20 Calcium/calmodulin-dependent protein kinase type II subunit a 7.5 0.5 12 Apolipoprotein D 8.6 0.5 20 Calcium/calmodulin-dependent protein kinase type II subunit g 7.2 0.5 14 Ig kappa chain V-III region VG 8.6 0.6 20 Calcium-binding protein 39 7.9 0.6 20 Apoptosis-associated speck-like protein containing a CARD 8.6 0.6 20 Calmodulin 9.5 0.3 20 Phosphatidylethanolamine-binding protein 1 8.6 0.5 20 Calmodulin-like protein 3 8.5 1 Proteasome subunit a type-3 8.6 0.4 20 Calmodulin-like protein 5 6.6 0.8 7 Vitronectin 8.6 0.5 20 Calnexin 7.5 0.9 20 Calpain-1 catalytic subunit 8.6 0.5 20 Calpain small subunit 1 8.1 0.5 19 Alpha-1-antichymotrypsin 8.5 0.5 20 Calpain-1 catalytic subunit 8.6 0.5 20 Spectrin beta chain, non-erythrocytic 1 8.5 0.5 20 Calpain-2 catalytic subunit 7.2 0.6 7 Ig lambda chain V-III region LOI 8.5 0.4 20 Calpastatin 7.1 0.7 7 Uncharacterized protein KIAA1328 8.5 0.5 20 Calponin-2 7.9 0.7 17 Fumarylacetoacetase 8.5 0.3 20 Calreticulin 8.0 0.9 20 Serine/threonine-protein phosphatase CPPED1 8.5 0.3 20 Calretinin 7.4 0.6 9 Peptidyl-prolyl cis-trans isomerase FKBP1A 8.5 0.5 20 Calsyntenin-1 6.9 0.9 3 Alpha-2-antiplasmin 8.5 0.4 20 cAMP-dependent protein kinase type I-a regulatory subunit 7.6 0.2 19 Transitional endoplasmic reticulum ATPase 8.5 0.7 20 cAMP-dependent protein kinase type II-a regulatory subunit 7.2 0.5 11 Acylamino-acid-releasing enzyme 8.5 0.4 20 CapZ-interacting protein 6.7 0.8 6 Puromycin-sensitive aminopeptidase 8.5 0.5 20 Carbonic anhydrase 1 9.0 0.6 20 Glutathione synthetase 8.5 0.3 20 Carbonic anhydrase 2 7.9 0.6 20 Translin 8.5 0.5 20 Carbonyl reductase [NADPH] 1/3 7.5 0.4 8 Glucose-6-phosphate 1-dehydrogenase 8.4 0.7 20 Carboxypeptidase B2 6.8 0.6 9 Nicotinamide phosphoribosyltransferase 8.4 0.7 20 Carboxypeptidase N catalytic chain 7.4 0.8 8 Heme-binding protein 2 8.4 0.4 20 Carboxypeptidase N subunit 2 7.3 0.6 13 Inter-alpha-trypsin-inhibitor heavy chain H4 8.4 0.8 20 Carcinoembryonic antigen-related cell adhesion molecule 1 8.1 0.7 19 Proteasome subunit alpha type-4 8.4 0.6 20 Carcinoembryonic antigen-related cell adhesion molecule 5 8.3 1 Transgelin-2 8.4 0.5 20 Carcinoembryonic antigen-related cell adhesion molecule 6 8.8 0.5 20 Grancalcin 8.4 0.7 20 Carcinoembryonic antigen-related cell adhesion molecule 8 9.2 0.5 20 Coactosin-like protein 8.4 0.5 20 Caspase recruitment domain-containing protein 9 7.2 0.3 15 WAP four-disulfide core domain protein 3 8.4 0.5 20 Caspase-14 6.2 0.4 3 ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 2 8.4 0.6 20 Catalase 10.2 0.3 20 Selenium-binding protein 1 8.4 0.4 20 Cathelicidin antimicrobial peptide LL-37 8.4 0.8 20 Cathelicidin antimicrobial peptide LL-37 8.4 0.8 20 Cathepsin B 7.0 0.5 11 14-3-3 protein a/b 8.4 0.7 20 Cathepsin D 7.1 0.6 18 Actin-related protein 2/3 complex subunit 3 8.4 0.6 20 Cathepsin G 9.0 0.6 20 Ig lambda chain V-III region SH 8.4 0.4 20 Cathepsin L1 6.7 0.6 7 Integrin b-2 8.4 0.5 20 Cathepsin S 8.0 0.4 20 Fatty acid-binding protein, epidermal 8.4 0.3 20 CB1 cannabinoid receptor-interacting protein 1 6.7 0.7 3 Glutathione peroxidase 3 8.4 0.5 20 CD109 antigen 8.2 1 Prosaposin 8.3 0.7 20 CD44 antigen 7.4 0.4 5 C4b-binding protein alpha chain 8.3 0.4 20 CD63 antigen 7.4 0.7 18 Proteasome subunit beta type-3 8.3 0.4 20 CD97 antigen 7.4 0.4 5 Acyl-CoA-binding protein 8.3 0.5 20 Cell division control protein 42 homolog 7.6 0.8 13 Aspartate aminotransferase, cytoplasmic 8.3 0.4 20 Ceruloplasmin 9.4 0.5 20 EF-hand domain-containing protein D2 8.3 0.7 20 Charged multivesicular body protein 4a 6.8 1 Cytidine deaminase 8.3 0.5 20 Charged multivesicular body protein 4b 6.5 0.3 6 Ig kappa chain V-I region Wes 8.3 0.4 20 Chitinase-3-like protein 1/YKL-40 9.0 0.4 19 Glutaredoxin-1 8.3 0.5 20 Chitotriosidase-1 8.7 0.7 19 Thymosin b-4 8.3 0.6 20 Chloride intracellular channel protein 1 8.1 0.7 18 N-acetylgalactosamine-6-sulfatase 8.3 0.4 20 Cholesteryl ester transfer protein 7.0 0.1 2 Vitamin D-binding protein 8.3 1.1 20 Choline transporter-like protein 2 7.3 0.2 6 Ubiquitin-conjugating enzyme E2 variant 1 8.3 0.6 20 Choline/ethanolamine kinase 7.1 0.3 4 Inter-alpha-trypsin inhibitor heavy chain H1 8.3 0.6 20 Cholinesterase 7.0 0.4 7 Glial fibrillary acidic protein 8.3 0.9 20 Chromobox protein homolog 3 7.8 0.4 18 Elongation factor 1-g 8.2 0.4 20 Chromogranin-A 6.5 0.6 5 Beta-glucuronidase 8.2 0.5 20 Citrate synthase 7.4 0.8 14 Ig kappa chain V-III region CLL 8.2 0.6 20 Clathrin heavy chain 1 8.1 0.6 20 Lysosomal alpha-mannosidase 8.2 0.5 20 Cleavage and polyadenylation specificity factor subunit 5 7.3 0.4 8 Galectin-10 8.2 0.6 20 Clusterin 7.9 0.7 16 D-dopachrome decarboxylase 8.2 0.5 20 C-Myc-binding protein 6.8 0.2 3 Copine-3 8.2 0.4 20 Coactosin-like protein 8.4 0.5 20 Syntenin-1 8.2 0.5 20 Coagulation factor V 7.2 1 N-acetylglucosamine-6-sulfatase 8.2 0.5 20 Coagulation factor X 7.6 1 Spectrin alpha chain, erythrocytic 1 8.2 0.6 20 Coagulation factor XII 7.4 0.8 5 Histone H1.0 8.2 0.5 20 Coagulation factor XIII B chain 7.1 0.4 3 Ribonuclease T2 8.2 0.5 20 Coatomer subunit b 7.1 0.5 6 Corticosteroid-binding globulin 8.2 0.5 20 Cofilin-1 8.3 0.7 19 Proteasome subunit b type 8.2 0.4 20 Coiled-coil domain-containing protein 150 6.9 0.8 10 Integrin a-M 8.2 0.9 20 Collagen alpha-1(I) chain 7.3 0.6 12 Serpin B6 8.2 0.4 20 Collagen alpha-1(III) chain 6.9 0.5 11 Phosphoglucomutase-2 8.2 0.7 20 Collagen alpha-1(V) chain 7.3 0.4 5 Peptidyl-prolyl cis-trans isomerase B 8.1 0.6 20 Collagen alpha-1(VI) chain 7.1 0.6 3 Clathrin heavy chain 1 8.1 0.6 20 Collagen alpha-1(VII) chain 7.3 0.6 4 Rho GDP-dissociation inhibitor 1 8.1 0.6 20 Collagen alpha-1(XII) chain 7.9 0.3 13 Adenosine deaminase 8.1 0.3 20 Collagen alpha-1(XIV) chain 8.4 0.9 13 Glyoxalase domain-containing protein 4 8.1 0.5 20 Collagen alpha-1(XVIII) chain 6.4 1 Actin-related protein 2/3 complex subunit 5 8.1 0.7 20 Collagen alpha-2(I) chain 6.8 0.4 6 Cystatin-B 8.1 0.5 20 Collagen alpha-2(IV) chain 6.9 0.4 6 Ig kappa chain V-III region B6 8.1 0.5 20 Collagen alpha-2(V) chain 6.7 0.2 3 Dipeptidyl peptidase 1 8.1 0.5 20 Collagen alpha-3(VI) chain 7.4 0.5 18 Adenylate kinase 2, mitochondrial 8.1 0.6 20 COMM domain-containing protein 9 7.3 0.2 6 Aflatoxin B1 aldehyde reductase member 2 8.1 0.6 20 Complement C1q subcomponent subunit A 7.2 0.3 2 Ig lambda variable 3-25 8.1 0.6 20 Complement C1q subcomponent subunit B 7.6 0.3 12 Serum amyloid P-component 8.1 0.6 20 Complement C1q subcomponent subunit C 7.1 0.7 8 Glutathione peroxidase 1 8.1 0.6 20 Complement C1r subcomponent 7.2 0.7 14 Proteasome subunit b type-4 8.1 0.4 20 Complement C1r subcomponent-like protein 6.4 0.7 4 Actin-related protein 2/3 complex subunit 1B 8.0 0.7 20 Complement C1s subcomponent 7.3 0.6 10 Ig kappa chain V-I region Roy 8.0 0.5 20 Complement C2 7.5 0.7 9 Annexin A4 8.0 0.9 20 Complement C3 10.3 0.4 20 Calreticulin 8.0 0.9 20 Complement C4-A 7.4 0.6 10 Kallistatin 8.0 0.6 20 Complement C4-B 9.6 0.5 20 Ig heavy chain V-III region KOL 8.0 0.4 20 Complement C5 8.1 0.6 19 Cytochrome c 8.0 0.4 20 Complement component C6 7.4 0.6 12 Ig kappa chain V-I region BAN 8.0 0.4 20 Complement component C7 7.6 0.5 12 Aspartate aminotransferase, mitochondrial 8.0 0.4 20 Complement component C8 a chain 6.8 0.7 14 Protein disulfide-isomerase A3 8.0 0.8 20 Complement component C8 b chain 7.6 0.5 11 Cathepsin S 8.0 0.4 20 Complement component C8 gamma chain 7.4 0.4 7 Brain acid soluble protein 1 8.0 0.6 20 Complement component C9 7.9 0.7 16 Ig lambda chain V-II region NIG-84 7.9 0.3 20 Complement factor B 8.8 0.5 20 Hepatoma-derived growth factor 7.9 0.3 20 Complement factor D 7.5 1 Carbonic anhydrase 2 7.9 0.6 20 Complement factor H 7.5 0.9 18 Calcium-binding protein 39 7.9 0.6 20 Complement factor H-related protein 1/2 7.1 0.6 9 Acid ceramidase 7.8 0.5 20 Complement factor I 7.7 0.5 20 Ras-related protein Rab-11 7.8 0.7 20 Complement receptor type 1 6.9 0.0 2 Heterogeneous nuclear ribonucleoprotein A1 7.8 0.7 20 COP9 signalosome complex subunit 3 7.1 0.8 4 Apolipoprotein A-II 7.8 0.9 20 COP9 signalosome complex subunit 4 7.0 0.4 11 Complement factor I 7.7 0.5 20 COP9 signalosome complex subunit 5 7.1 0.6 12 Heat shock 70 kDa protein 6 7.7 0.4 20 COP9 signalosome complex subunit 8 7.6 1 Ribose-5-phosphate isomerase 7.7 0.5 20 Copine-2 7.0 0.5 9 Interleukin enhancer-binding factor 3 7.7 0.6 20 Copine-3 8.2 0.4 20 Alpha-2-HS-glycoprotein 7.7 0.8 20 Core histone macro-H2A.1 8.1 0.6 16 Gamma-glutamylcyclotransferase 7.7 0.4 20 Coronin-1A 9.3 0.3 20 Glucosidase 2 subunit b 7.7 0.6 20 Coronin-1C 7.1 0.7 17 Lysosome-associated membrane glycoprotein 1 7.7 0.4 20 Corticosteroid-binding globulin 8.2 0.5 20 Translin-associated protein X 7.7 0.4 20 Costars family protein ABRACL 8.0 0.8 18 Dipeptidyl peptidase 3 7.6 0.6 20 C-reactive protein 8.0 0.9 19 Tyrosine-protein phosphatase non-receptor type substrate 1 7.6 0.4 20 Creatine kinase B-type 8.1 0.8 17 Na+/H+ exchange regulatory cofactor NHE-RF1 7.6 0.5 20 Crk-like protein 7.3 0.7 10 Allograft inflammatory factor 1 7.6 0.7 20 CTP synthase 1 6.9 0.5 2 Plasma kallikrein 7.6 0.6 20 C-type lectin domain family 11 member A 6.9 0.1 3 Apolipoprotein B receptor 7.6 0.5 20 Cullin-1 7.3 0.3 8 Versican core protein 7.6 0.7 20 Cullin-2 6.9 0.2 4 N(G),N(G)-dimethylarginine dimethylaminohydrolase 1 7.6 0.5 20 Cullin-3 7.5 0.4 11 Serpin B8 7.5 0.4 20 Cullin-4A 6.6 1

Calnexin 7.5 0.9 20 Cullin-4B 6.1 0.2 7 Proteasome subunit b type-7 7.5 0.3 20 Cullin-associated NEDD8-dissociated protein 1 7.7 0.7 16 Pterin-4-alpha-carbinolamine dehydratase 7.4 0.5 20 Cystatin-A 9.6 0.3 20 Zyxin 7.1 0.6 20 Cystatin-B 8.1 0.5 20 High affinity choline transporter 1 9.5 0.7 19 Cystatin-C 7.3 0.4 16 Actin, alpha skeletal muscle 9.4 0.5 19 Cysteine-rich secretory protein 3 6.1 0.7 7 Rab GDP dissociation inhibitor beta 9.3 0.4 19 Cysteine--tRNA ligase, cytoplasmic 7.1 0.5 8 Glutathione S-transferase P 9.2 0.5 19 Cytidine deaminase 8.3 0.5 20 L-lactate dehydrogenase B chain 9.1 0.4 19 Cytochrome b-245 heavy chain 7.7 1.0 11 Chitinase-3-like protein 1/YKL-40 9.0 0.4 19 Cytochrome b-245 light chain 7.4 0.5 7 Nucleoside diphosphate kinase 8.8 0.3 19 Cytochrome b5 7.2 0.4 10 Adenosylhomocysteinase 8.7 0.4 19 Cytochrome b-c1 complex subunit 1, mitochondrial 6.9 0.6 9 Annexin A5 8.7 0.9 19 Cytochrome b-c1 complex subunit 2, mitochondrial 7.6 0.0 2 Olfactomedin-4 8.7 0.8 19 Cytochrome c 8.0 0.4 20 Chitotriosidase-1 8.7 0.7 19 Cytochrome c oxidase subunit 4 isoform 1, mitochondrial 7.1 1.0 4 Proteasome subunit b type-8 8.6 0.3 19 Cytochrome c oxidase subunit 5A, mitochondrial 8.2 0.3 4 Actin-related protein 2/3 complex subunit 4 8.6 0.5 19 Cytochrome c1, heme protein, mitochondrial 8.0 0.1 2 Proteasome subunit b type-10 8.5 0.5 19 Cytochrome P450 4X1 7.5 0.3 11 Macrophage migration inhibitory factor 8.5 0.6 19 Cytokine receptor-like factor 3 6.9 0.4 7 Erythrocyte band 7 integral membrane protein 8.5 0.9 19 Cytoplasmic aconitate hydratase 6.8 0.5 2 Ig heavy variable 3/OR16-13 8.4 0.3 19 Cytoplasmic dynein 1 heavy chain 1 7.4 0.5 5 Gamma-glutamyl hydrolase 8.4 0.5 19 Cytoplasmic FMR1-interacting protein 2 7.2 0.4 10 Major vault protein 8.4 0.7 19 Cytoskeleton-associated protein 4 7.0 0.8 7 F-actin-capping protein subunit a-1 8.4 0.7 19 Cytosol aminopeptidase 7.1 0.7 10 Cofilin-1 8.3 0.7 19 Cytosolic non-specific dipeptidase 7.4 0.5 15 Proteasome subunit a type 8.3 0.3 19 Cytosolic purine 5-nucleotidase 7.8 0.6 16 Synaptic vesicle membrane protein VAT-1 homolog 8.3 0.6 19 D-dopachrome decarboxylase 8.2 0.5 20 Heat shock protein HSP 90-beta 8.3 0.3 19 Dehydrogenase/reductase SDR family member 7 7.5 0.3 3 Ig heavy chain V-I region V35 8.2 0.5 19 Delta(3,5)-Delta(2,4)-dienoyl-CoA isomerase, mitochondrial 6.9 0.5 6 Peptidoglycan recognition protein 1 8.2 0.4 19 Delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial 7.1 0.6 3 Tryptophan--tRNA ligase, cytoplasmic 8.2 0.6 19 Delta-aminolevulinic acid dehydratase 8.0 0.6 18 Apolipoprotein E 8.2 0.9 19 Dermcidin 7.6 1 High mobility group protein B2 8.2 0.5 19 Desmoglein-2 7.5 0.3 8 Annexin A11 8.2 0.7 19 Desmoplakin 8.0 0.5 12 Beta-hexosaminidase subunit b 8.2 0.3 19 Dickkopf-related protein 3 6.3 0.0 2 Carcinoembryonic antigen-related cell adhesion molecule 1 8.1 0.7 19 Dihydrolipoyl dehydrogenase, mitochondrial 7.6 0.4 17 Trypstatin 8.1 0.7 19 Dihydrolipoyllysine-residue succinyltransferase component of

Afamin 8.1 0.8 19 2-oxoglutarate dehydrogenase complex 7.4 0.6 10 Proteasome subunit b type-6 8.1 0.2 19 Dihydropteridine reductase 7.4 0.6 8 Sec1 family domain-containing protein 1 8.1 0.5 19 Dihydropyrimidinase-related protein 1 7.4 0.3 13 Complement C5 8.1 0.6 19 Dihydropyrimidinase-related protein 2 8.1 0.9 16 Lysosomal Pro-X carboxypeptidase 8.1 0.6 19 Dihydropyrimidine dehydrogenase [NADP(+)] 6.9 0.3 9 Tubulin b-4B chain 8.1 0.7 19 Di-N-acetylchitobiase 7.2 0.6 19 Growth factor receptor-bound protein 2 8.1 0.3 19 Dipeptidyl aminopeptidase-like protein 6 6.8 1 Tubulin a-1C chain 8.1 0.9 19 Dipeptidyl peptidase 1 8.1 0.5 20 Calpain small subunit 1 8.1 0.5 19 Dipeptidyl peptidase 2 7.2 0.6 17 Spectrin beta chain, erythrocytic 8.1 0.5 19 Dipeptidyl peptidase 3 7.6 0.6 20 C-reactive protein 8.0 0.9 19 Diphosphoinositol polyphosphate phosphohydrolase 1 7.1 0.3 5 Superoxide dismutase [Cu-Zn] 8.0 0.8 19 dNA primase large subunit 10.4 0.3 20 V-type proton ATPase catalytic subunit A 8.0 1.0 19 DNA primase large subunit 9.4 0.4 20 6-phosphogluconolactonase 8.0 0.4 19 DNA topoisomerase 2 7.0 0.7 14 Thioredoxin reductase 1, cytoplasmic 8.0 0.3 19 DNA-(apurinic or apyrimidinic site) lyase 7.8 0.5 15 Peroxiredoxin-1 8.0 0.7 19 DNA-binding protein RFX7 7.5 0.3 3 Ig heavy chain V-II region ARH-77 8.0 0.4 19 DnaJ homolog subfamily B member 11 7.9 0.2 2 Hexokinase-3 8.0 0.9 19 DnaJ homolog subfamily C member 13 7.3 0.4 6 UTP--glucose-1-phosphate uridylyltransferase 8.0 0.9 19 Dolichyl-diphosphooligosaccharide--protein glycosyltransferase 48 kDa subunit 7.4 0.4 3 Elongation factor 1-d 8.0 0.7 19 Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1 7.3 0.7 13 Elongation factor 2 8.0 0.7 19 Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2 7.9 0.6 7 Glycogenin-1 7.9 0.6 19 Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit DAD1 7.4 0.1 2 Beta-hexosaminidase 7.9 0.7 19 Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3B 7.7 0.3 4 Ig lambda variable 6-57 7.9 0.5 19 Dopamine beta-hydroxylase 6.3 0.7 3 Ig gamma-4 chain C region 7.9 0.8 19 Drebrin-like protein 7.3 0.8 14 Protein CutA 7.9 0.6 19 Dual specificity mitogen-activated protein kinase kinase 1 6.5 0.3 8 Bleomycin hydrolase 7.9 0.4 19 Dynactin subunit 1 7.7 0.6 19 Flavin reductase (NADPH) 7.9 0.8 19 Dynactin subunit 2 7.1 0.6 8 Ig lambda variable 16-47 7.9 0.4 19 Dynamin-2 6.9 0.7 9 Galectin-3-binding protein 7.9 0.7 19 Dynein heavy chain 5, axonemal 7.6 1 Tenascin 7.9 0.7 19 Dynein heavy chain 8, axonemal 7.3 0.3 11 Malate dehydrogenase, mitochondrial 7.9 0.8 19 Dynein heavy chain 9, axonemal 7.7 0.5 9 Ribulose-phosphate 3-epimerase 7.9 0.5 19 Dysferlin 7.8 0.6 15 Heterogeneous nuclear ribonucleoproteins C1/C2 7.8 0.7 19 E2/E3 hybrid ubiquitin-protein ligase UBE2O 6.0 0.6 3 Programmed cell death 6-interacting protein 7.8 0.8 19 E3 ubiquitin-protein ligase CBL 6.7 0.5 10 Bridging integrator 2 7.8 0.5 19 E3 ubiquitin-protein ligase UBR4 5.4 1 NAD(P)H-hydrate epimerase 7.8 0.4 19 Echinoderm microtubule-associated protein-like 2 7.4 0.4 15 Dynactin subunit 1 7.7 0.6 19 Echinoderm microtubule-associated protein-like 4 7.1 0.5 14 Apolipoprotein A-IV 7.7 0.8 19 Ectonucleotide pyrophosphatase/phosphodiesterase family member 2 7.3 0.4 13 Protein kinase C and casein kinase substrate in neurons protein 2 7.7 0.6 19 EF-hand domain-containing protein D2 8.3 0.7 20 Sulfhydryl oxidase 1 7.7 0.4 19 EH domain-containing protein 1 7.7 0.5 14 Adipocyte plasma membrane-associated protein 7.7 1.0 19 Electron transfer flavoprotein subunit alpha, mitochondrial 5.9 0.0 2 Voltage-gated potassium channel subunit b-2 7.7 0.5 19 Electron transfer flavoprotein subunit b 6.6 0.1 5 Hyaluronan-binding protein 2 7.7 0.7 19 Elongation factor 1-a 1/2 7.7 0.8 6 Inter-alpha-trypsin inhibitor heavy chain H2 7.7 1.0 19 Elongation factor 1-b 7.8 0.7 13 Interferon-induced 35 kDa protein 7.6 0.6 19 Elongation factor 1-d 8.0 0.7 19 cAMP-dependent protein kinase type I-a regulatory subunit 7.6 0.2 19 Elongation factor 1-g 8.2 0.4 20 Thyroxine-binding globulin 7.6 0.5 19 Elongation factor 2 8.0 0.7 19 Argininosuccinate lyase 7.6 0.6 19 Elongation factor Tu, mitochondrial 7.7 0.1 2 Serine/threonine-protein phosphatase 2A activator 7.6 0.6 19 Endoplasmic reticulum aminopeptidase 1 7.1 0.6 10 Ig kappa chain V-I region DEE 7.6 0.5 19 Endoplasmic reticulum resident protein 29 7.5 0.7 16 Myeloid cell nuclear differentiation antigen 7.6 0.8 19 Endoplasmin 7.6 0.8 18 Ezrin 7.6 0.6 19 Endorepellin 7.3 0.9 7 Ribosyldihydronicotinamide dehydrogenase [quinone] 7.5 0.5 19 Engulfment and cell motility protein 1/2 6.9 0.6 8 Xaa-Pro dipeptidase 7.5 0.4 19 Enhancer of rudimentary homolog 7.5 0.4 17 Ig lambda variable 3-10 7.5 0.6 19 Enolase-phosphatase E1 7.5 0.4 15 Prolyl endopeptidase 7.5 0.4 19 Eosinophil cationic protein 8.8 0.5 20 Transforming growth factor-b-induced protein ig-h3 7.4 0.5 19 Eosinophil peroxidase 7.4 0.7 10 Thioredoxin-dependent peroxide reductase, mitochondrial 7.4 0.7 19 Epidermal growth factor receptor substrate 15 7.2 0.5 12 Apolipoprotein C-II 7.3 0.9 19 Epidermal growth factor receptor substrate 15-like 1 6.4 0.7 9 Ig lambda variable 3-9 7.3 0.7 19 Epididymis-specific alpha-mannosidase 7.3 0.2 5 Di-N-acetylchitobiase 7.2 0.6 19 Erlin-1 7.5 0.7 7 Ras-related protein Rab-8B 7.0 0.6 19 Erlin-2 7.4 0.3 4 Glycogen [starch] synthase, muscle 8.7 0.8 18 ERO1-like protein a 7.6 0.3 17 Protein DJ-1 8.4 0.6 18 Erythrocyte band 7 integral membrane protein 8.5 0.9 19 Ras-related protein Rab-7a 8.4 0.4 18 Erythrocyte membrane protein band 4.2 7.3 0.8 14 Protein FAM49B 8.4 1.2 18 Erythroid membrane-associated protein 6.6 1 Hypoxanthine-guanine phosphoribosyltransferase 8.4 0.3 18 Ester hydrolase C11orf54 7.4 0.7 16 LisH domain-containing protein ARMC9 8.3 0.5 18 Eukaryotic initiation factor 4A-I 6.8 0.8 14 Gamma-enolase 8.3 0.9 18 Eukaryotic translation initiation factor 2 subunit 1 6.6 0.4 9 Band 3 anion transport protein 8.2 1.0 18 Eukaryotic translation initiation factor 3 subunit J 6.5 0.6 6 Ig alpha-2 chain C region 8.1 0.5 18 Eukaryotic translation initiation factor 4B 6.4 0.6 14 Angiotensinogen/Angiotensin 8.1 0.9 18 Eukaryotic translation initiation factor 5A-1 7.2 0.4 15 Phosphoglucomutase-1 8.1 0.5 18 Exportin-1 7.4 0.4 2 Ig heavy chain V-III region GAL 8.1 0.4 18 Exportin-2 7.8 0.7 16 Ubiquitin-conjugating enzyme E2 N 8.1 0.6 18 Exportin-7 6.8 0.7 9 Thymidine phosphorylase 8.1 0.8 18 Extracellular matrix protein 1 6.9 0.7 6 Heparin cofactor 2 8.1 0.5 18 Extracellular superoxide dismutase [Cu-Zn] 6.7 0.8 10 Chloride intracellular channel protein 1 8.1 0.7 18 Ezrin 7.6 0.6 19 Twinfilin-2 8.1 0.6 18 F-actin-capping protein subunit a-1 8.4 0.7 19 Costars family protein ABRACL 8.0 0.8 18 F-actin-capping protein subunit a-2 7.2 0.7 14 Delta-aminolevulinic acid dehydratase 8.0 0.6 18 F-actin-capping protein subunit b 8.7 0.6 20 ADP-ribosylation factor 1/3 8.0 0.6 18 Far upstream element-binding protein 1 7.1 0.4 14 Receptor-type tyrosine-protein phosphatase C 7.9 0.7 18 Farnesyl pyrophosphate synthase 8.0 0.4 17 Platelet-activating factor acetylhydrolase IB subunit b 7.9 0.6 18 Fascin 6.5 0.6 4 Stathmin 7.9 0.3 18 Fatty acid synthase 7.3 0.4 9 Guanine nucleotide-binding protein G(i) subunit a-2 7.8 0.7 18 Fatty acid-binding protein, epidermal 8.4 0.3 20 Proteasome activator complex subunit 1 7.8 0.7 18 Fatty acid-binding protein, heart 7.1 0.4 7 Lymphocyte-specific protein 1 7.8 0.6 18 F-box only protein 7 6.3 0.3 3 Adenylate kinase isoenzyme 1 7.8 0.7 18 Fermitin family homolog 3 7.1 0.7 15 Heterogeneous nuclear ribonucleoprotein D0 7.8 0.5 18 Ferritin heavy chain 9.7 0.3 20 Bradykinin 7.8 1.0 18 Ferritin light chain 9.7 0.4 20 Protein disulfide-isomerase A6 7.8 0.8 18 Fetuin-B 7.0 0.6 3 Chromobox protein homolog 3 7.8 0.4 18 Fibrinogen a chain 9.0 0.6 20 Ig lambda chain V-I region NIG-64 7.8 0.3 18 Fibrinogen beta chain 9.5 0.7 20 Tyrosine-protein phosphatase non-receptor type 6 7.8 0.7 18 Fibrinogen gamma chain 9.1 0.7 20 Ubiquitin-like modifier-activating enzyme 1 7.7 0.7 18 Fibronectin 9.1 0.5 20 BTB/POZ domain-containing protein KCTD12 7.7 0.4 18 Fibulin-1 8.3 1 Phospholipid transfer protein 7.7 0.8 18 Ficolin-2 6.6 0.4 2 Ig lambda-like polypeptide 1 7.7 0.5 18 Ficolin-3 7.3 0.4 9 Ig lambda chain V region 4A 7.7 0.4 18 Filamin-A 9.8 0.3 20 Galectin-3 7.7 0.4 18 Filamin-B 6.9 0.4 12 Plasminogen 7.7 0.6 18 Filamin-C 7.3 0.7 7 Ubiquitin thioesterase OTUB1 7.7 0.6 18 Flavin reductase (NADPH) 7.9 0.8 19 Ig lambda variable 1-40 7.6 0.4 18 Flotillin-1 7.0 0.8 13 60 kDa SS-A/Ro ribonucleoprotein 7.6 0.5 18 Flotillin-2 7.2 0.8 17 Transcobalamin-1 7.6 0.4 18 Follistatin-related protein 1 6.7 0.6 4 Ig heavy chain V-III region BUT 7.6 0.4 18 Formin-binding protein 1 7.2 0.4 17 Tubulin beta chain 7.6 0.9 18 Formin-like protein 1 7.4 0.5 7 NAD kinase 7.6 0.4 18 Fructose-1,6-bisphosphatase 1 8.0 0.5 17 Quinone oxidoreductase PIG3 7.6 0.4 18 Fructose-1,6-bisphosphatase isozyme 2 6.9 0.2 6 Endoplasmin 7.6 0.8 18 Fructose-bisphosphate aldolase A 9.5 0.3 20 Programmed cell death protein 6 7.6 0.6 18 Fructose-bisphosphate aldolase C 8.6 0.4 20 N(4)-(beta-N-acetylglucosaminyl)-L-asparaginase 7.5 0.5 18 Fumarate hydratase, mitochondrial 7.2 0.5 11 UV excision repair protein RAD23 homolog B 7.5 0.6 18 Fumarylacetoacetase 8.5 0.3 20 10 kDa heat shock protein, mitochondrial 7.5 0.7 18 Galectin-1 7.4 0.5 12 Nuclear mitotic apparatus protein 1 7.5 0.8 18 Galectin-10 8.2 0.6 20 Complement factor H 7.5 0.9 18 Galectin-3 7.7 0.4 18 CD63 antigen 7.4 0.7 18 Galectin-3-binding protein 7.9 0.7 19 Collagen alpha-3(VI) chain 7.4 0.5 18 Gamma-enolase 8.3 0.9 18 Heat shock 70 kDa protein 4 7.4 0.6 18 Gamma-glutamyl hydrolase 8.4 0.5 19 Histone H2A type 2-B 7.3 0.9 18 Gamma-glutamylcyclotransferase 7.7 0.4 20 RNA-binding motif protein, X chromosome 7.2 0.7 18 Gamma-synuclein 5.8 0.5 6 Rho GTPase-activating protein 25 7.2 0.5 18 Ganglioside GM2 activator 7.4 0.5 17 Cathepsin D 7.1 0.6 18 Gelsolin 9.5 0.4 20 Nucleoside diphosphate kinase A 7.0 0.7 18 Glia maturation factor gamma 7.5 0.4 14 Plasminogen activator inhibitor 1 6.8 0.6 18 Glial fibrillary acidic protein 8.3 0.9 20 Retinoblastoma-like protein 1 8.3 0.8 17 Glucosamine-6-phosphate isomerase 1 7.6 0.4 17 Rab GDP dissociation inhibitor a 8.3 0.5 17 Glucose 1-dehydrogenase/6-phosphogluconolactonase 7.4 0.3 13 Importin subunit b-1 8.1 0.7 17 Glucose-6-phosphate 1-dehydrogenase 8.4 0.7 20 Creatine kinase B-type 8.1 0.8 17 Glucose-6-phosphate isomerase 9.8 0.5 20 2,3-cyclic-nucleotide 3-phosphodiesterase 8.1 0.8 17 Glucosidase 2 subunit b 7.7 0.6 20 Farnesyl pyrophosphate synthase 8.0 0.4 17 Glutamate dehydrogenase 1, mitochondrial 7.4 0.5 16 Fructose-1,6-bisphosphatase 1 8.0 0.5 17 Glutamate--cysteine ligase catalytic subunit 6.7 0.5 10 Ig lambda chain V-I region VOR 7.9 0.3 17 Glutaminase kidney isoform, mitochondrial 6.8 1 Calponin-2 7.9 0.7 17 Glutamine synthetase 7.2 0.9 15 ATP-binding cassette sub-family B member 9 7.9 0.4 17 Glutamine-dependent NAD(+) synthetase 6.8 0.4 7 WD repeat-containing protein 1 7.9 0.9 17 Glutaminyl-peptide cyclotransferase 6.7 0.3 14 Tumor protein D54 7.8 0.4 17 Glutaredoxin-1 8.3 0.5 20 Ig lambda variable 2-18 7.8 0.4 17 Glutathione peroxidase 7.3 0.4 13 14-3-3 protein gamma 7.8 0.4 17 Glutathione peroxidase 1 8.1 0.6 20 Metalloproteinase inhibitor 1 7.7 0.3 17 Glutathione peroxidase 3 8.4 0.5 20 Retinol-binding protein 4 7.7 0.8 17 Glutathione reductase, mitochondrial 8.7 0.5 20 Inositol monophosphatase 1 7.7 0.4 17 Glutathione S-transferase kappa 1 8.0 0.5 4 Annexin A7 7.7 0.6 17 Glutathione S-transferase Mu 1/4 7.2 0.6 14 Neutrophil cytosol factor 1 7.7 0.6 17 Glutathione S-transferase Mu 2/4 6.8 0.3 6 Pigment epithelium-derived factor 7.6 0.8 17 Glutathione S-transferase omega-1 8.8 0.5 20 High mobility group protein B1 7.6 0.6 17 Glutathione S-transferase P 9.2 0.5 19 Protein XRP2 7.6 0.5 17 Glutathione synthetase 8.5 0.3 20 Glucosamine-6-phosphate isomerase 1 7.6 0.4 17 Glyceraldehyde-3-phosphate dehydrogenase 9.6 0.9 20 Vesicle transport through interaction with t-SNAREs homolog 1B 7.6 0.6 17 Glycerol-3-phosphate dehydrogenase, mitochondrial 7.3 0.5 4 Protein CREG1 7.6 0.6 17 Glycine cleavage system H protein, mitochondrial 6.6 0.5 4 Phospholysine phosphohistidine inorganic pyrophosphate phosphatase 7.6 0.5 17 Glycogen [starch] synthase, muscle 8.7 0.8 18 Ig lambda variable 8-61 7.6 0.5 17 Glycogen debranching enzyme 7.4 0.5 8 3-mercaptopyruvate sulfurtransferase 7.6 0.6 17 Glycogen phosphorylase, liver form 9.1 0.5 20 THO complex subunit 4 7.6 0.4 17 Glycogenin-1 7.9 0.6 19 Ig lambda variable 2-14 7.6 0.5 17 Glycolipid transfer protein 7.7 0.5 13 Isoaspartyl peptidase/L-asparaginase 7.6 0.4 17 Glycophorin-A 6.3 1 Plectin 7.6 0.8 17 Glyoxalase domain-containing protein 4 8.1 0.5 20 Dihydrolipoyl dehydrogenase, mitochondrial 7.6 0.4 17 Golgi membrane protein 1 6.7 1 ERO1-like protein a 7.6 0.3 17 Golgi-associated plant pathogenesis-related protein 1 7.3 0.3 11 Enhancer of rudimentary homolog 7.5 0.4 17 Grancalcin 8.4 0.7 20 Pentraxin-related protein PTX3 7.5 0.7 17 Growth factor receptor-bound protein 2 8.1 0.3 19 Proteasome subunit b type-5 7.5 0.4 17 GTP cyclohydrolase 1 feedback regulatory protein 7.3 0.3 3 Heterogeneous nuclear ribonucleoprotein K 7.5 0.5 17 GTP-binding nuclear protein Ran 7.6 0.6 15 Ras-related protein Rab-5C 7.5 0.5 17 Guanine deaminase 7.1 0.3 5 Prothrombin 7.4 0.5 17 Guanine nucleotide-binding protein G(i) subunit a-2 7.8 0.7 18 1,4-alpha-glucan-branching enzyme 7.4 0.8 17 Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit b-1 7.4 0.4 15 Isoamyl acetate-hydrolyzing esterase 1 homolog 7.4 0.7 17 Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit b-3 7.2 0.4 13 Peroxisomal acyl-coenzyme A oxidase 1 7.4 0.5 17 Guanine nucleotide-binding protein G(o) subunit a 7.1 0.6 5 Ganglioside GM2 activator 7.4 0.5 17 Guanine nucleotide-binding protein G(q) subunit a 6.8 0.1 2 Apolipoprotein M 7.3 0.5 17 Guanine nucleotide-binding protein subunit b-4 7.4 0.6 16 Ras-related protein Rab-1A/B 7.3 0.9 17 Guanine nucleotide-binding protein subunit g 7.1 0.4 5 Ras-related protein Rab-10 7.3 0.6 17 Haloacid dehalogenase-like hydrolase domain-containing protein 2 7.4 0.5 16 Bisphosphoglycerate mutase 7.3 0.6 17 Haptoglobin 10.1 0.4 20 Dipeptidyl peptidase 2 7.2 0.6 17 Haptoglobin-related protein 9.7 0.4 20 Flotillin-2 7.2 0.8 17 Heat shock 70 kDa protein 1A/1B 9.2 0.6 20 RAS protein activator like-3 7.2 0.3 17 Heat shock 70 kDa protein 4 7.4 0.6 18 Formin-binding protein 1 7.2 0.4 17 Heat shock 70 kDa protein 6 7.7 0.4 20 Acyl-protein thioesterase 1 7.1 0.6 17 Heat shock cognate 71 kDa protein 8.9 0.5 20 Arylsulfatase B 7.1 0.4 17 Heat shock protein 105 kDa 6.4 1 Coronin-1C 7.1 0.7 17 Heat shock protein HSP 90-alpha 8.7 0.5 20 Neutrophil cytosol factor 2 7.1 0.5 17 Heat shock protein HSP 90-beta 8.3 0.3 19 Translationally-controlled tumor protein 7.1 0.5 17 Hematological and neurological expressed 1 protein 6.0 0.4 2 Small nuclear ribonucleoprotein Sm D2 7.0 0.4 17 Hematopoietic lineage cell-specific protein 6.7 0.9 8 Tropomyosin alpha-1 chain 7.0 0.6 17 Heme oxygenase 1 6.7 0.6 10 Twinfilin-1 6.7 0.4 17 Heme oxygenase 2 6.6 0.3 7 Myristoylated alanine-rich C-kinase substrate 6.6 0.7 17 Heme-binding protein 1 7.0 0.5 16 Histidine-rich glycoprotein 8.3 1.1 16 Heme-binding protein 2 8.4 0.4 20 Apolipoprotein C-I 8.2 0.7 16 Hemoglobin subunit alpha (HBA1) 11.5 0.3 20 Core histone macro-H2A.1 8.1 0.6 16 Hemoglobin subunit alpha (HBA2) 9.4 0.8 20 Dihydropyrimidinase-related protein 2 8.1 0.9 16 Hemoglobin subunit beta 11.4 0.3 20 Myotrophin 8.0 0.4 16 Hemoglobin subunit delta 9.9 0.4 20 Clusterin 7.9 0.7 16 Hemoglobin subunit gamma-2 7.4 0.8 11 Protein S100-B 7.9 0.8 16 Hemoglobin subunit gamma-1 8.7 0.7 20 Complement component C9 7.9 0.7 16 Hemoglobin subunit mu 7.2 0.5 2 Acidic leucine-rich nuclear phosphoprotein 32 family member B 7.9 0.8 16 Hemoglobin subunit theta-1 7.1 0.5 11 Protein S100-A1 7.9 0.5 16 Hemopexin 9.7 0.5 20 Exportin-2 7.8 0.7 16 Heparin cofactor 2 8.1 0.5 18 Ig J chain 7.8 0.6 16 Hepatocyte growth factor-like protein 6.8 0.1 3 Tubulin-specific chaperone A 7.8 0.5 16 Hepatoma-derived growth factor 7.9 0.3 20 Cytosolic purine 5-nucleotidase 7.8 0.6 16 Hepatoma-derived growth factor-related protein 2 7.0 0.2 3 Isocitrate dehydrogenase [NADP] cytoplasmic 7.8 0.5 16 Heterochromatin protein 1-binding protein 3 7.2 0.4 4 Cullin-associated NEDD8-dissociated protein 1 7.7 0.7 16 Heterogeneous nuclear ribonucleoprotein A1 7.8 0.7 20 60S acidic ribosomal protein P2 7.6 0.6 16 Heterogeneous nuclear ribonucleoprotein D0 7.8 0.5 18 Ankyrin-1 7.6 0.7 16 Heterogeneous nuclear ribonucleoprotein F/H 7.3 0.1 7 Thioredoxin domain-containing protein 17 7.6 0.5 16 Heterogeneous nuclear ribonucleoprotein H3 6.4 1 ATP-dependent dihydroxyacetone kinase/FAD-AMP lyase 7.6 0.8 16 Heterogeneous nuclear ribonucleoprotein K 7.5 0.5 17 Stress-induced-phosphoprotein 1 7.5 0.5 16 Heterogeneous nuclear ribonucleoprotein L 7.3 0.2 5 14-3-3 protein theta 7.5 0.6 16 Heterogeneous nuclear ribonucleoprotein Q 7.3 0.5 9 Interleukin enhancer-binding factor 2 7.5 0.5 16 Heterogeneous nuclear ribonucleoprotein U 7.7 0.2 2 Endoplasmic reticulum resident protein 29 7.5 0.7 16 Heterogeneous nuclear ribonucleoprotein U-like protein 2 7.6 1 U6 snRNA-associated Sm-like protein LSm8 7.5 0.6 16 Heterogeneous nuclear ribonucleoproteins A2/B1 7.6 0.6 15 Arylsulfatase A 7.5 0.4 16 Heterogeneous nuclear ribonucleoproteins C1/C2 7.8 0.7 19 Haloacid dehalogenase-like hydrolase domain-containing protein 2 7.4 0.5 16 Hexokinase-1 7.2 0.5 2 Alcohol dehydrogenase [NADP+] 7.4 0.5 16 Hexokinase-3 8.0 0.9 19 Adenosine kinase 7.4 0.5 16 High affinity choline transporter 1 9.5 0.7 19 Small nuclear ribonucleoprotein E 7.4 0.5 16 High affinity immunoglobulin epsilon receptor subunit g 6.5 0.5 6 Ester hydrolase C11orf54 7.4 0.7 16 High mobility group protein B1 7.6 0.6 17 Ig heavy chain V-II region WAH 7.4 0.6 16 High mobility group protein B2 8.2 0.5 19 T-complex protein 1 subunit b 7.4 0.6 16 High mobility group protein HMG-I/HMG-Y 6.9 0.5 6 Guanine nucleotide-binding protein subunit b-4 7.4 0.6 16 Hippocalcin-like protein 1 7.1 0.4 12 Proteoglycan 4 7.4 1.1 16 Histidine-rich glycoprotein 8.3 1.1 16 Glutamate dehydrogenase 1, mitochondrial 7.4 0.5 16 Histidine--tRNA ligase, cytoplasmic 7.2 0.5 14 Ig kappa chain V-I region AU 7.3 0.4 16 Histone H1.0 8.2 0.5 20 Cystatin-C 7.3 0.4 16 Histone H1.2 7.6 0.7 2 Putative GTP cyclohydrolase 1 type 2 NIF3L1 7.3 0.4 16 Histone H1.3 7.8 0.4 13 Protein disulfide-isomerase A4 7.3 0.8 16 Histone H1.4 7.3 1.2 16 Protein phosphatase 1 regulatory subunit 12A 7.3 0.4 16 Histone H1.5 7.7 0.8 10 Histone H1.4 7.3 1.2 16 Histone H1x 7.3 0.6 9 Nucleoprotein TPR 7.3 0.5 16 Histone H2A type 1-B/C/E/type 3 8.4 0.3 5 NADH-cytochrome b5 reductase 3 7.3 0.4 16 Histone H2A type 1-J 9.6 0.5 20 Ubiquitin-conjugating enzyme E2 L3 7.2 0.9 16 Histone H2A type 2-B 7.3 0.9 18 Adenylosuccinate lyase 7.2 0.5 16 Histone H2B 10.1 0.6 20 WW domain-binding protein 2 7.2 0.3 16 Histone H3 9.5 0.4 20 IgGFc-binding protein 7.2 0.5 16 Histone H4 9.9 0.9 20 Ig heavy variable 3/OR15-7 7.2 0.4 16 HLA class I histocompatibility antigen, Cw-14 a chain 7.3 0.1 3 Syntaxin-3 7.1 0.5 16 HLA class I histocompatibility antigen, Cw-4 a chain 7.4 0.6 9 26S proteasome non-ATPase regulatory subunit 2 7.1 0.6 16 HLA class II histocompatibility antigen, DRB1-8/11 b chain 7.0 0.4 3 Heme-binding protein 1 7.0 0.5 16 Hsc70-interacting protein 7.4 0.4 9 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase b-2 7.0 0.8 16 Hsp90 co-chaperone Cdc37 6.9 0.7 13 Adenine phosphoribosyltransferase 6.9 0.4 16 Hyaluronan and proteoglycan link protein 2 7.3 0.4 13 Calcineurin B homologous protein 1 6.9 0.6 16 Hyaluronan-binding protein 2 7.7 0.7 19 Ig heavy variable 4-4 8.2 0.6 15 Hydroxyacylglutathione hydrolase, mitochondrial 7.4 0.3 4 Neutrophil cytosol factor 4 8.1 0.7 15 Hydroxypyruvate isomerase 6.8 1 Acidic leucine-rich nuclear phosphoprotein 32 family member A 8.0 0.5 15 Hydroxysteroid dehydrogenase-like protein 2 7.4 0.4 4 Leucine-rich repeat-containing protein 10B 7.9 0.6 15 Hypoxanthine-guanine phosphoribosyltransferase 8.4 0.3 18 Ras-related protein Rap-1b 7.9 0.5 15 Hypoxia up-regulated protein 1 7.2 0.3 6 Osteoclast-stimulating factor 1 7.9 0.5 15 ICOS ligand 6.7 1 DNA-(apurinic or apyrimidinic site) lyase 7.8 0.5 15 Ig alpha-1 chain C region 10.0 0.5 20 14-3-3 protein eta 7.8 0.6 15 Ig alpha-2 chain C region 8.1 0.5 18 Dysferlin 7.8 0.6 15 Ig delta chain C region 7.3 0.8 13 Apolipoprotein C-III 7.7 0.8 15 Ig gamma-1 chain C region 10.5 0.3 20 Ragulator complex protein LAMTOR5 7.7 0.4 15 Ig gamma-2 chain C region 9.3 0.5 20 Inter-alpha-trypsin inhibitor heavy chain H3 7.7 0.8 15 Ig gamma-3 chain C region 8.7 0.3 20 Splicing factor U2AF 65 kDa subunit 7.7 0.6 15 Ig gamma-4 chain C region 7.9 0.8 19 AP-2 complex subunit b 7.7 0.5 15 Ig heavy chain V-I region EU 7.2 0.4 4 Heterogeneous nuclear ribonucleoproteins A2/B1 7.6 0.6 15 Ig heavy chain V-I region HG3 7.3 0.2 4 Syntaxin-7 7.6 0.3 15 Ig heavy chain V-I region V35 8.2 0.5 19 Actin, gamma 1 7.6 0.5 15 Ig heavy chain V-II region ARH-77 8.0 0.4 19 Lamin-B2 7.6 0.7 15 Ig heavy chain V-II region WAH 7.4 0.6 16 GTP-binding nuclear protein Ran 7.6 0.6 15 Ig heavy chain V-III region BRO 8.9 0.3 20 Enolase-phosphatase E1 7.5 0.4 15 Ig heavy chain V-III region BUT 7.6 0.4 18 Retinal dehydrogenase 1 7.5 0.7 15 Ig heavy chain V-III region GAL 8.1 0.4 18 Ig lambda chain V-V region DEL 7.5 0.4 15 Ig heavy chain V-III region GAR 7.0 0.4 4 Uncharacterized protein C9orf142 7.5 0.5 15 Ig heavy chain V-III region JON 7.4 0.6 11 60S acidic ribosomal protein P1 7.5 0.6 15 Ig heavy chain V-III region KOL 8.0 0.4 20 Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit b-1 7.4 0.4 15 Ig heavy chain V-III region LAY 7.7 0.9 13 Ig lambda chain V-I region NEW 7.4 0.5 15 Ig heavy chain V-III region TIL 8.7 0.4 20 Peroxiredoxin-4 7.4 0.5 15 Ig heavy chain V-III region WEA 7.2 0.4 11 Toll-interacting protein 7.4 0.4 15 Ig heavy chain V-III region ZAP 7.1 0.5 4 Cytosolic non-specific dipeptidase 7.4 0.5 15 Ig kappa chain V-I region AU 7.3 0.4 16 RNA-binding protein EWS 7.4 0.4 15 Ig kappa chain V-I region BAN 8.0 0.4 20 ATP-citrate synthase 7.4 0.5 15 Ig kappa chain V-I region CAR 6.5 0.6 3 Echinoderm microtubule-associated protein-like 2 7.4 0.4 15 Ig kappa chain V-I region DEE 7.6 0.5 19 NSFL1 cofactor p47 7.4 0.4 15 Ig kappa chain V-I region EU 8.8 0.3 20 Platelet-activating factor acetylhydrolase IB subunit a 7.4 0.5 15 Ig kappa chain V-I region HK101 7.1 0.3 3 Pyruvate kinase (PKM2) 7.4 0.4 15 Ig kappa chain V-I region HK102 7.3 0.1 2 Prelamin-A/C 7.4 0.7 15 Ig kappa chain V-I region Kue 7.1 0.3 9 Serine/arginine repetitive matrix protein 1 7.3 0.6 15 Ig kappa chain V-I region Lay 7.4 0.4 13 Alpha-adducin 7.3 0.6 15 Ig kappa chain V-I region Mev 7.4 0.6 8 Kell blood group glycoprotein 7.3 0.6 15 Ig kappa chain V-I region Ni 8.7 0.3 20 Protein diaphanous homolog 1 7.3 0.9 15 Ig kappa chain V-I region Roy 8.0 0.5 20 Protein-arginine deiminase type-2 7.3 0.8 15 Ig kappa chain V-I region Scw 6.7 0.2 2 Ras-related protein Rab-21 7.3 0.5 15 Ig kappa chain V-I region WEA 9.4 0.3 20 Insulin-like growth factor-binding protein complex acid labile subunit 7.3 0.4 15 Ig kappa chain V-I region Wes 8.3 0.4 20 LIM and SH3 domain protein 1 7.3 0.6 15 Ig kappa chain V-II region FR 7.3 0.6 5 Caspase recruitment domain-containing protein 9 7.2 0.3 15 Ig kappa chain V-II region GM607 9.2 0.6 20 Glutamine synthetase 7.2 0.9 15 Ig kappa chain V-II region MIL 6.9 1 Eukaryotic translation initiation factor 5A-1 7.2 0.4 15 Ig kappa chain V-II region RPMI 6410 7.4 0.1 2 Ras suppressor protein 1 7.1 0.7 15 Ig kappa chain V-II region TEW 8.2 1 Fermitin family homolog 3 7.1 0.7 15 Ig kappa chain V-III region B6 8.1 0.5 20 Laminin subunit g-1 7.1 0.4 15 Ig kappa chain V-III region CLL 8.2 0.6 20 Sialic acid synthase 6.8 0.7 15 Ig kappa chain V-III region IARC/BL41 7.7 0.4 13 Vesicle-associated membrane protein-associated protein A/B/C 6.8 0.6 15 Ig kappa chain V-III region NG9 8.8 0.6 20 Nuclear ubiquitous casein and cyclin-dependent kinase substrate 1 6.8 0.6 15 Ig kappa chain V-III region POM 7.6 0.4 13 Smoothelin-like protein 2 8.7 0.4 14 Ig kappa chain V-III region SIE 9.8 0.3 20 Low affinity immunoglobulin gamma Fc region receptor III-B 8.2 0.3 14 Ig kappa chain V-III region VG 8.6 0.6 20 S-methyl-5-thioadenosine phosphorylase 8.0 0.5 14 Ig kappa chain V-IV region Len 9.3 0.3 20 Serum paraoxonase/arylesterase 1 7.9 0.8 14 Ig kappa chain V-IV region STH 6.6 0.6 14 Vascular non-inflammatory molecule 2 7.8 0.3 14 Ig lambda chain V region 4A 7.7 0.4 18 Serum amyloid A-1 protein 7.8 1.1 14 Ig lambda chain V-I region NEW 7.4 0.5 15 Attractin 7.8 0.3 14 Ig lambda chain V-I region NIG-64 7.8 0.3 18 N-acetyl-D-glucosamine kinase 7.8 0.6 14 Ig lambda chain V-I region VOR 7.9 0.3 17 Lipopolysaccharide-binding protein 7.8 0.5 14 Ig lambda chain V-I region WAH 8.8 0.4 20 Transforming protein RhoA/B/C 7.7 0.5 14 Ig lambda chain V-II region BUR 7.6 0.8 12 EH domain-containing protein 1 7.7 0.5 14 Ig lambda chain V-II region NIG-84 7.9 0.3 20 T-complex protein 1 subunit theta 7.6 0.5 14 Ig lambda chain V-II region TRO 6.9 0.6 10 Isocitrate dehydrogenase [NADP], mitochondrial 7.6 0.9 14 Ig lambda chain V-III region LOI 8.5 0.4 20 Neutral alpha-glucosidase AB 7.6 0.6 14 Ig lambda chain V-III region SH 8.4 0.4 20 V-type proton ATPase subunit G 1 7.6 0.6 14 Ig lambda chain V-IV region Hil 8.7 0.4 20 Ribonuclease inhibitor 7.6 0.5 14 Ig lambda chain V-V region DEL 7.5 0.4 15 Sodium/potassium-transporting ATPase subunit a-1 7.5 0.8 14 Ig lambda chain V-VI region AR 7.0 0.2 2 Ragulator complex protein LAMTOR3 7.5 0.6 14 Ig lambda chain V-VI region WLT 7.5 0.4 8 Plasma serine protease inhibitor 7.5 0.7 14 Ig lambda-1 chain C regions 10.0 0.3 20 Nicotinamide mononucleotide adenylyltransferase 1 7.5 0.4 14 Ig lambda-2 chain C regions 9.4 0.3 20 Glia maturation factor gamma 7.5 0.4 14 Ig mu chain C region 9.2 0.5 20 Neurofilament light polypeptide 7.5 0.8 14 IgGFc-binding protein 7.2 0.5 16 Nicastrin 7.5 0.8 14 Ig heavy variable 3/OR15-7 7.2 0.4 16 S-adenosylmethionine synthase isoform type-2 7.4 0.5 14 Ig heavy variable 3/OR16-13 8.4 0.3 19 Phosphatidylinositol-glycan-specific phospholipase D 7.4 0.5 14 Ig heavy variable 3-64 6.9 0.4 4 Nicotinate phosphoribosyltransferase 7.4 0.8 14 Ig heavy variable 4-4 8.2 0.6 15 Receptor-type tyrosine-protein phosphatase eta 7.4 0.5 14 Ig J chain 7.8 0.6 16 Citrate synthase 7.4 0.8 14 Ig lambda variable 1-40 7.6 0.4 18 Multifunctional protein ADE2 7.3 0.5 14 Ig lambda variable 16-47 7.9 0.4 19 Erythrocyte membrane protein band 4.2 7.3 0.8 14 Ig lambda variable 2-14 7.6 0.5 17 Proteasome activator complex subunit 2 7.3 0.6 14 Ig lambda variable 2-18 7.8 0.4 17 C4b-binding protein beta chain 7.3 0.8 14 Ig lambda variable 3-1 7.1 0.4 10 ATP synthase subunit alpha, mitochondrial 7.3 0.9 14 Ig lambda variable 3-10 7.5 0.6 19 Drebrin-like protein 7.3 0.8 14 Ig lambda variable 3-19 7.3 0.4 8 Glutathione S-transferase Mu 1/4 7.2 0.6 14 Ig lambda variable 3-21 8.9 0.3 20 Histidine--tRNA ligase, cytoplasmic 7.2 0.5 14 Ig lambda variable 3-25 8.1 0.6 20 Pantetheinase 7.2 0.7 14 Ig lambda variable 3-27 7.3 0.4 11 F-actin-capping protein subunit a-2 7.2 0.7 14 Ig lambda variable 3-9 7.3 0.7 19 Complement C1r subcomponent 7.2 0.7 14 Ig lambda variable 6-57 7.9 0.5 19 Calcium/calmodulin-dependent protein kinase type II subunit g 7.2 0.5 14 Ig lambda variable 8-61 7.6 0.5 17 Transcription initiation factor IIA subunit 1 7.2 0.5 14 Ig lambda-like polypeptide 1 7.7 0.5 18 Myosin-7B 7.1 0.8 14 Ig superfamily containing leucine-rich repeat protein 6.1 0.6 2 Echinoderm microtubule-associated protein-like 4 7.1 0.5 14 Importin subunit b-1 8.1 0.7 17 Far upstream element-binding protein 1 7.1 0.4 14 Importin-5 7.1 0.4 10 DNA topoisomerase 2 7.0 0.7 14 Importin-7 6.9 0.3 2 Protein FAM107B 7.0 0.8 14 Importin-9 6.7 0.4 2 Vitamin K-dependent protein S 7.0 1.0 14 Inorganic pyrophosphatase 7.5 0.2 7 Apolipoprotein L1 6.9 1.1 14 Inositol monophosphatase 1 7.7 0.4 17 Eukaryotic initiation factor 4A-I 6.8 0.8 14 Inositol monophosphatase 2 7.5 0.3 12 Nucleobindin-1 6.8 0.6 14 Inositol polyphosphate 1-phosphatase 7.4 0.4 7 Complement component C8 a chain 6.8 0.7 14 Insulin-like growth factor-binding protein 3 6.7 0.3 5 Glutaminyl-peptide cyclotransferase 6.7 0.3 14 Insulin-like growth factor-binding protein 7 7.4 1 Ig kappa chain V-IV region STH 6.6 0.6 14 Insulin-like growth factor-binding protein complex acid labile subunit 7.3 0.4 15 Eukaryotic translation initiation factor 4B 6.4 0.6 14 Integral membrane protein 2B 7.4 0.3 2 Collagen alpha-1(XIV) chain 8.4 0.9 13 Integrin a-M 8.2 0.9 20 Collagen alpha-1(XII) chain 7.9 0.3 13 Integrin b-2 8.4 0.5 20 Histone H1.3 7.8 0.4 13 Integrin beta-1 7.3 0.2 4 Low affinity immunoglobulin gamma Fc region receptor III-A 7.8 0.6 13 Inter-alpha-trypsin inhibitor heavy chain H1 8.3 0.6 20 Elongation factor 1-b 7.8 0.7 13 Inter-alpha-trypsin inhibitor heavy chain H2 7.7 1.0 19 Aldehyde dehydrogenase family 16 member A1 7.8 0.5 13 Inter-alpha-trypsin inhibitor heavy chain H3 7.7 0.8 15 Ig heavy chain V-III region LAY 7.7 0.9 13 Inter-alpha-trypsin-inhibitor heavy chain H4 8.4 0.8 20 Annexin A2 7.7 0.7 13 Intercellular adhesion molecule 1 6.4 0.5 4 Prostaglandin-H2 D-isomerase 7.7 0.7 13 Interferon-induced 35 kDa protein 7.6 0.6 19 Ig kappa chain V-III region IARC/BL41 7.7 0.4 13 Interferon-induced guanylate-binding protein 1/2 7.3 0.8 13 Glycolipid transfer protein 7.7 0.5 13 Interferon-induced transmembrane protein 1/2/3 7.2 0.3 7 Nucleolin 7.7 0.5 13 Interleukin enhancer-binding factor 2 7.5 0.5 16 Cell division control protein 42 homolog 7.6 0.8 13 Interleukin enhancer-binding factor 3 7.7 0.6 20 Tropomodulin-3 7.6 0.7 13 Interleukin-1 receptor-like 1 7.2 0.2 5 Ig kappa chain V-III region POM 7.6 0.4 13 Intersectin-2 6.4 0.3 12 Aminopeptidase B 7.5 0.5 13 Interstitial collagenase 7.3 0.3 3 UDP-glucose:glycoprotein glucosyltransferase 1 7.5 0.6 13 Isoamyl acetate-hydrolyzing esterase 1 homolog 7.4 0.7 17 S-formylglutathione hydrolase 7.4 0.5 13 Isoaspartyl peptidase/L-asparaginase 7.6 0.4 17 Tyrosine-protein kinase HCK/Fyn/Yes/Proto-oncogene tyrosine- protein kinase Src 7.4 0.5 13 Isocitrate dehydrogenase [NADP] cytoplasmic 7.8 0.5 16 Barrier-to-autointegration factor 7.4 0.4 13 Isocitrate dehydrogenase [NADP], mitochondrial 7.6 0.9 14 Neurofilament medium polypeptide 7.4 0.7 13 Kallikrein-6 7.1 1 Ig kappa chain V-I region Lay 7.4 0.4 13 Kallistatin 8.0 0.6 20 ADP-sugar pyrophosphatase 7.4 0.4 13 Kell blood group glycoprotein 7.3 0.6 15 Synaptosomal-associated protein 23 7.4 0.5 13 Ketosamine-3-kinase 6.8 0.7 7 Lumican 7.4 0.6 13 KH domain-containing, RNA-binding, signal transduction-associated protein 1 7.1 0.4 10 Glucose 1-dehydrogenase/6-phosphogluconolactonase 7.4 0.3 13 Kinesin heavy chain isoform 5C 7.1 1 V-type proton ATPase subunit E 1 7.4 0.5 13 Kinesin-1 heavy chain 7.1 0.5 6 Dihydropyrimidinase-related protein 1 7.4 0.3 13 Lactotransferrin 10.5 0.3 20 Interferon-induced guanylate-binding protein 1/2 7.3 0.8 13 Lamin-B receptor 7.4 0.6 6 Ectonucleotide pyrophosphatase/phosphodiesterase family member 2 7.3 0.4 13 Lamin-B1 8.7 0.5 20 Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1 7.3 0.7 13 Lamin-B2 7.6 0.7 15 Carboxypeptidase N subunit 2 7.3 0.6 13 Laminin subunit alpha-4 6.9 0.4 6 Prefoldin subunit 4 7.3 0.7 13 Laminin subunit alpha-5 7.0 0.2 8 Hyaluronan and proteoglycan link protein 2 7.3 0.4 13 Laminin subunit beta-1 6.9 0.5 10 Ubiquitin-conjugating enzyme E2 K 7.3 0.3 13 Laminin subunit beta-3 6.2 1 Ig delta chain C region 7.3 0.8 13 Laminin subunit gamma-1 7.1 0.4 15 Ubiquitin carboxyl-terminal hydrolase 15 7.3 0.5 13 Laminin subunit gamma-2 7.6 0.1 2 Poly(ADP-ribose) glycohydrolase ARH3 7.3 0.5 13 Latexin 7.1 0.5 12 Glutathione peroxidase 7.3 0.4 13 Leucine-rich alpha-2-glycoprotein 8.9 0.5 20 Rho GTPase-activating protein 1 7.2 0.8 13 Leucine-rich repeat flightless-interacting protein 1 7.2 0.7 13 BH3-interacting domain death agonist 7.2 0.6 13 Leucine-rich repeat-containing protein 10B 7.9 0.6 15 Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit b-3 7.2 0.4 13 Leucyl-cystinyl aminopeptidase 7.3 0.5 9 Leucine-rich repeat flightless-interacting protein 1 7.2 0.7 13 Leukocyte elastase inhibitor 9.7 0.3 20 Medium-chain specific acyl-CoA dehydrogenase 7.2 0.6 13 Leukocyte immunoglobulin-like receptor subfamily A member 1/2/3/4/6 7.2 0.3 10 S-phase kinase-associated protein 1 7.1 0.5 13 Leukocyte surface antigen CD47 7.5 0.7 11 Flotillin-1 7.0 0.8 13 Leukotriene A-4 hydrolase 9.0 0.5 20 Mitochondrial fission 1 protein 6.9 0.7 13 LIM and SH3 domain protein 1 7.3 0.6 15 T-complex protein 1 subunit eta 6.9 0.6 13 Lipopolysaccharide-binding protein 7.8 0.5 14 Hsp90 co-chaperone Cdc37 6.9 0.7 13 LisH domain-containing protein ARMC9 8.3 0.5 18 Myelin basic protein 6.8 1.0 13 Liver carboxylesterase 1 7.4 0.3 4 Syntaxin-binding protein 2 6.7 0.5 13 L-lactate dehydrogenase A chain 9.3 0.6 20 60S acidic ribosomal protein P0 6.0 1.0 13 L-lactate dehydrogenase B chain 9.1 0.4 19 Long-chain enoyl-CoA hydratase/Long chain 3-hydroxyacyl-CoA Desmoplakin 8.0 0.5 12 dehydrogenase 7.4 0.5 5 Adenylosuccinate synthetase isozyme 2 7.7 0.6 12 Long-chain-fatty-acid--CoA ligase 1/5 6.7 1 Ig lambda chain V-II region BUR 7.6 0.8 12 Low affinity immunoglobulin gamma Fc region receptor III-A 7.8 0.6 13 X-ray repair cross-complementing protein 6 7.6 0.7 12 Low affinity immunoglobulin gamma Fc region receptor III-B 8.2 0.3 14 Complement component C7 7.6 0.5 12 Low molecular weight phosphotyrosine protein phosphatase 7.2 0.5 11 Complement C1q subcomponent subunit B 7.6 0.3 12 Lumican 7.4 0.6 13 Ubiquitin carboxyl-terminal hydrolase isozyme L1 7.5 0.4 12 Lupus La protein 6.6 0.1 3 Arachidonate 5-lipoxygenase 7.5 0.9 12 Lymphocyte-specific protein 1 7.8 0.6 18 Calcium/calmodulin-dependent protein kinase type II subunit a 7.5 0.5 12 Lysine--tRNA ligase 7.1 0.2 5 Mitochondrial peptide methionine sulfoxide reductase 7.5 0.5 12 Lysosomal alpha-mannosidase 8.2 0.5 20 Inositol monophosphatase 2 7.5 0.3 12 Lysosomal Pro-X carboxypeptidase 8.1 0.6 19 Serum amyloid A-4 protein 7.4 0.7 12 Lysosome-associated membrane glycoprotein 1 7.7 0.4 20 Putative deoxyribose-phosphate aldolase 7.4 0.5 12 Lysosome-associated membrane glycoprotein 2 9.0 0.5 20 Complement component C6 7.4 0.6 12 Lysozyme C 8.9 0.4 20 PITH domain-containing protein 1 7.4 0.5 12 m7GpppX diphosphatase 7.2 0.6 10 Galectin-1 7.4 0.5 12 Macrophage colony-stimulating factor 1 receptor 6.3 0.0 2 Collagen alpha-1(I) chain 7.3 0.6 12 Macrophage migration inhibitory factor 8.5 0.6 19 Prefoldin subunit 2 7.3 0.3 12 Macrophage-capping protein 8.7 0.4 20 Amyloid beta A4 precursor protein-binding Major prion protein 6.6 0.1 2 family B member 1-interacting protein 7.3 0.8 12 Major vault protein 8.4 0.7 19 Epidermal growth factor receptor substrate 15 7.2 0.5 12 Malate dehydrogenase, cytoplasmic 8.9 0.6 20 Bifunctional purine biosynthesis protein PURH 7.2 0.6 12 Malate dehydrogenase, mitochondrial 7.9 0.8 19 Prenylcysteine oxidase 1 7.2 0.4 12 Maltase-glucoamylase, intestinal 9.0 0.4 20 Protein unc-13 homolog D 7.2 0.3 12 Mannose-1-phosphate guanyltransferase b 7.0 0.3 7 Platelet basic protein 7.2 0.7 12 Mannose-binding protein C 7.3 0.1 4 Signal recognition particle 9 kDa protein 7.1 0.4 12 Mannosyl-oligosaccharide glucosidase 7.1 0.4 6 Tripeptidyl-peptidase 2 7.1 0.4 12 MAP7 domain-containing protein 1 6.2 0.3 4 COP9 signalosome complex subunit 5 7.1 0.6 12 MARCKS-related protein 6.2 0.4 6 Proliferation-associated protein 2G4 7.1 0.5 12 Matrix metalloproteinase-9 9.3 0.6 20 AP-1 complex subunit beta-1 7.1 0.4 12 Matrix-remodeling-associated protein 5 6.5 0.0 2 Latexin 7.1 0.5 12 Medium-chain specific acyl-CoA dehydrogenase 7.2 0.6 13 Hippocalcin-like protein 1 7.1 0.4 12 Melanoma inhibitory activity protein 3 6.8 0.5 3 Filamin-B 6.9 0.4 12 Metalloproteinase inhibitor 1 7.7 0.3 17 N(G),N(G)-dimethylarginine dimethylaminohydrolase 2 6.9 0.4 12 Methionine adenosyltransferase 2 subunit b 6.9 0.4 8 Ubiquitin carboxyl-terminal hydrolase 6.9 0.4 12 Methylenetetrahydrofolate dehydrogenase 5.9 0.3 3 Obg-like ATPase 1 6.8 0.5 12 Methylosome subunit pICln 7.2 1 Sorcin 6.7 0.4 12 MICOS complex subunit MIC60 7.1 0.2 3 Intersectin-2 6.4 0.3 12 Microtubule-associated protein 1B 7.5 0.7 10 Myelin proteolipid protein 8.3 0.8 11 Microtubule-associated protein tau 6.6 0.2 2 Tubulin alpha-3C/D/E chain 7.9 0.9 11 Mini-chromosome maintenance complex-binding protein 6.7 1.1 10 Cytochrome b-245 heavy chain 7.7 1.0 11 Minor histocompatibility protein HA-1 5.9 0.3 2 55 kDa erythrocyte membrane protein 7.6 0.6 11 Mitochondrial 2-oxoglutarate/malate carrier protein 7.5 0.6 4 Complement component C8 b chain 7.6 0.5 11 Mitochondrial fission 1 protein 6.9 0.7 13 Unconventional myosin-Ie/f 7.6 0.7 11 Mitochondrial peptide methionine sulfoxide reductase 7.5 0.5 12 Leukocyte surface antigen CD47 7.5 0.7 11 Mitogen-activated protein kinase 1 7.2 0.5 8 Cullin-3 7.5 0.4 11 MOB kinase activator 1A/B 6.7 0.5 9 Cytochrome P450 4X1 7.5 0.3 11 Moesin 9.4 0.4 20 Hemoglobin subunit g-2 7.4 0.8 11 Monocyte differentiation antigen CD14 7.8 0.5 6 Perilipin-3 7.4 0.8 11 Mucin-1 7.4 1 Ig heavy chain V-III region JON 7.4 0.6 11 Mucin-16 7.7 1 Putative nucleoside diphosphate kinase 7.3 0.2 11 Multifunctional protein ADE2 7.3 0.5 14 Dynein heavy chain 8, axonemal 7.3 0.3 11 Multiple inositol polyphosphate phosphatase 1 6.8 1 Ig lambda variable 3-27 7.3 0.4 11 Myc box-dependent-interacting protein 1 7.4 0.2 5 Protein-L-isoaspartate O-methyltransferase 7.3 0.5 11 Myelin basic protein 6.8 1.0 13 Golgi-associated plant pathogenesis-related protein 1 7.3 0.3 11 Myelin P2 protein 7.1 0.5 6 Low molecular weight phosphotyrosine protein phosphatase 7.2 0.5 11 Myelin proteolipid protein 8.3 0.8 11 Ig heavy chain V-III region WEA 7.2 0.4 11 Myeloblastin 9.7 0.4 20 Small ubiquitin-related modifier 2/3/4 7.2 0.5 11 Myeloid cell nuclear differentiation antigen 7.6 0.8 19 cAMP-dependent protein kinase type II-a regulatory subunit 7.2 0.5 11 Myeloid-associated differentiation marker 7.7 0.6 7 Fumarate hydratase, mitochondrial 7.2 0.5 11 Myeloperoxidase 10.8 0.3 20 Thioredoxin-related transmembrane protein 1 7.2 0.5 11 Myosin light chain 4 5.8 1 Hemoglobin subunit theta-1 7.1 0.5 11 Myosin light polypeptide 6 9.3 0.5 20 Protein argonaute-2 7.1 0.5 11 Myosin regulatory light chain 12A 9.0 0.7 20 Voltage-dependent anion-selective channel protein 2 7.1 0.8 11 Myosin-6 6.9 0.3 2 COP9 signalosome complex subunit 4 7.0 0.4 11 Myosin-7B 7.1 0.8 14 Cathepsin B 7.0 0.5 11 Myosin-9 10.2 0.4 20 Pyridoxal phosphate phosphatase 7.0 0.5 11 Myotrophin 8.0 0.4 16 Tyrosine-protein phosphatase non-receptor type 11 6.9 0.4 11 Myristoylated alanine-rich C-kinase substrate 6.6 0.7 17 Beta-2-glycoprotein 1 6.9 0.8 11 N(4)-(beta-N-acetylglucosaminyl)-L-asparaginase 7.5 0.5 18 Collagen alpha-1(III) chain 6.9 0.5 11 N(G),N(G)-dimethylarginine dimethylaminohydrolase 1 7.6 0.5 20 Ribose-phosphate pyrophosphokinase 1 6.8 0.4 11 N(G),N(G)-dimethylarginine dimethylaminohydrolase 2 6.9 0.4 12 60 kDa heat shock protein, mitochondrial 6.7 0.8 11 Na+/H+ exchange regulatory cofactor NHE-RF1 7.6 0.5 20 Alpha-endosulfine 6.5 0.7 11 N-acetyl-D-glucosamine kinase 7.8 0.6 14 Small ubiquitin-related modifier 1 6.3 0.4 11 N-acetylgalactosamine-6-sulfatase 8.3 0.4 20 Ankyrin repeat domain-containing protein 36A/B 6.2 0.5 11 N-acetylglucosamine-6-sulfatase 8.2 0.5 20 Olfactory receptor 51J1 8.4 0.4 10 N-acetylmuramoyl-L-alanine amidase 7.2 0.4 10 Peroxiredoxin-5, mitochondrial 8.0 0.8 10 NAD kinase 7.6 0.4 18 Ras-related C3 botulinum toxin substrate 2 7.9 0.5 10 NAD(P)H-hydrate epimerase 7.8 0.4 19 Transcription factor 20 7.7 0.3 10 NAD-dependent malic enzyme, mitochondrial 7.1 0.8 7 Histone H1.5 7.7 0.8 10 NAD-dependent protein deacetylase sirtuin-2 7.0 0.7 6 Pyridoxal kinase 7.6 0.5 10 NADH dehydrogenase [ubiquinone] 1 a subcomplex subunit 10, mitochondrial 7.4 0.2 2 Small glutamine-rich tetratricopeptide repeat-containing protein a 7.6 0.5 10 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9 7.6 0.4 3 Sodium/potassium-transporting ATPase subunit b-1 7.5 0.6 10 NADH dehydrogenase [ubiquinone] 1 b subcomplex subunit 6 7.4 1 Microtubule-associated protein 1B 7.5 0.7 10 NADH dehydrogenase [ubiquinone] 1 b subcomplex subunit 8, mitochondrial 7.7 1 Target of Myb protein 1 7.4 0.3 10 NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial 7.2 0.6 7 Eosinophil peroxidase 7.4 0.7 10 NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial 7.5 0.1 2 ATP synthase subunit beta, mitochondrial 7.4 1.1 10 NADH-cytochrome b5 reductase 3 7.3 0.4 16 Apoptosis inhibitor 5 7.4 0.4 10 NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial 7.5 1 Nuclear transport factor 2 7.4 0.5 10 NADP-dependent malic enzyme 6.2 1 Thymopoietin 7.4 0.5 10 Nascent polypeptide-associated complex subunit a 7.2 0.4 5 Dihydrolipoyllysine-residue succinyltransferase component of Nck-associated protein 1-like 7.3 0.3 5 2-oxoglutarate dehydrogenase complex 7.4 0.6 10 NEDD8 7.5 0.7 8 Complement C4-A 7.4 0.6 10 Neprilysin 7.4 0.6 8 von Willebrand factor 7.3 0.7 10 Neural cell adhesion molecule 1 6.7 0.4 3 Rho-related GTP-binding protein RhoG 7.3 0.2 10 Neurofilament heavy polypeptide 6.2 0.2 2 Protein phosphatase 1A/B 7.3 0.5 10 Neurofilament light polypeptide 7.5 0.8 14 X-ray repair cross-complementing protein 5 7.3 0.9 10 Neurofilament medium polypeptide 7.4 0.7 13 Crk-like protein 7.3 0.7 10 Neuromodulin 6.4 0.4 2 Transgelin 7.3 0.7 10 Neutral alpha-glucosidase AB 7.6 0.6 14 Complement C1s subcomponent 7.3 0.6 10 Neutral amino acid transporter B(0) 7.4 1 Protein S100-A13 7.3 0.4 10 Neutrophil collagenase 9.1 0.4 20 Septin-7 7.2 0.3 10 Neutrophil cytosol factor 1 7.7 0.6 17 N-acetylmuramoyl-L-alanine amidase 7.2 0.4 10 Neutrophil cytosol factor 2 7.1 0.5 17 Ubiquilin-1 7.2 0.4 10 Neutrophil cytosol factor 4 8.1 0.7 15 Ras-related protein Rab-2A 7.2 0.4 10 Neutrophil elastase 8.7 0.6 20 Solute carrier family 2, facilitated glucose transporter member 1 7.2 0.7 10 Neutrophil gelatinase-associated lipocalin 9.9 0.3 20 V-type proton ATPase subunit C 1 7.2 0.5 10 N-formyl peptide receptor 2 7.0 0.5 9 Uroporphyrinogen decarboxylase 7.2 0.3 10 NHL repeat-containing protein 3 7.0 0.5 7 Cytochrome b5 7.2 0.4 10 Nicastrin 7.5 0.8 14 Protein phosphatase 1 regulatory subunit 7 7.2 0.2 10 Nicotinamide mononucleotide adenylyltransferase 1 7.5 0.4 14 Cytoplasmic FMR1-interacting protein 2 7.2 0.4 10 Nicotinamide phosphoribosyltransferase 8.4 0.7 20 Leukocyte immunoglobulin-like receptor subfamily A member 1/2/3/4/6 7.2 0.3 10 Nicotinate phosphoribosyltransferase 7.4 0.8 14 m7GpppX diphosphatase 7.2 0.6 10 Nitric oxide synthase, inducible 6.8 0.6 2 Ig lambda variable 3-1 7.1 0.4 10 N-myc-interactor 7.2 0.3 9 Cytosol aminopeptidase 7.1 0.7 10 Non-histone chromosomal protein HMG-14 6.5 0.5 10 Endoplasmic reticulum aminopeptidase 1 7.1 0.6 10 Non-secretory ribonuclease 8.8 0.5 20 KH domain-containing, RNA-binding, signal transduction- associated protein 1 7.1 0.4 10 Non-specific lipid-transfer protein 6.6 0.5 4 V-type proton ATPase subunit B, brain isoform 7.1 0.4 10 NSFL1 cofactor p47 7.4 0.4 15 Serine/arginine-rich splicing factor 3 7.1 0.5 10 Nuclear mitotic apparatus protein 1 7.5 0.8 18 Importin-5 7.1 0.4 10 Nuclear pore membrane glycoprotein 210 7.3 0.6 2 Thioredoxin-like protein 1 7.0 0.4 10 Nuclear receptor-interacting protein 1 7.3 0.4 3 Protein arginine N-methyltransferase 5 7.0 0.2 10 Nuclear transport factor 2 7.4 0.5 10 Src kinase-associated phosphoprotein 2 7.0 0.4 10 Nuclear ubiquitous casein and cyclin-dependent kinase substrate 1 6.8 0.6 15 Coiled-coil domain-containing protein 150 6.9 0.8 10 Nuclease-sensitive element-binding protein 1 7.2 1 Laminin subunit b-1 6.9 0.5 10 Nucleobindin-1 6.8 0.6 14 Phosphatidylcholine-sterol acyltransferase 6.9 0.5 10 Nucleolin 7.7 0.5 13 Ig lambda chain V-II region TRO 6.9 0.6 10 Nucleophosmin 8.9 0.4 20 Porphobilinogen deaminase 6.9 0.5 10 Nucleoprotein TPR 7.3 0.5 16 Extracellular superoxide dismutase [Cu-Zn] 6.7 0.8 10 Nucleoside diphosphate kinase 8.8 0.3 19 Mini-chromosome maintenance complex-binding protein 6.7 1.1 10 Nucleoside diphosphate kinase A 7.0 0.7 18 Heme oxygenase 1 6.7 0.6 10 Nucleosome assembly protein 1-like 4 6.8 0.6 7 E3 ubiquitin-protein ligase CBL 6.7 0.5 10 Obg-like ATPase 1 6.8 0.5 12 Ras-related protein Rab-8A 6.7 0.5 10 Olfactomedin-4 8.7 0.8 19 Glutamate--cysteine ligase catalytic subunit 6.7 0.5 10 Olfactory receptor 51J1 8.4 0.4 10 Non-histone chromosomal protein HMG-14 6.5 0.5 10 Oligodendrocyte-myelin glycoprotein 6.8 0.1 2 Dynein heavy chain 9, axonemal 7.7 0.5 9 Opioid growth factor receptor 6.8 0.4 9 Signal recognition particle 14 kDa protein 7.6 0.5 9 Osteoclast-stimulating factor 1 7.9 0.5 15 UPF0687 protein C20orf27 7.5 0.3 9 Osteopontin 7.7 0.1 2 Complement C2 7.5 0.7 9 Pantetheinase 7.2 0.7 14 Polyadenylate-binding protein 1/3 7.5 0.8 9 Parvalbumin alpha 7.8 0.5 5 Hsc70-interacting protein 7.4 0.4 9 Pentraxin-related protein PTX3 7.5 0.7 17 Serine/threonine-protein kinase 4 7.4 0.6 9 Peptidase inhibitor 16 7.3 1 Calretinin 7.4 0.6 9 Peptidoglycan recognition protein 1 8.2 0.4 19 AMP deaminase 3 7.4 0.5 9 Peptidyl-prolyl cis-trans isomerase A 9.1 0.7 20 HLA class I histocompatibility antigen, Cw-4 a chain 7.4 0.6 9 Peptidyl-prolyl cis-trans isomerase B 8.1 0.6 20 ATP-dependent RNA helicase DDX3X 7.3 0.6 9 Peptidyl-prolyl cis-trans isomerase FKBP1A 8.5 0.5 20 Ficolin-3 7.3 0.4 9 Perilipin-3 7.4 0.8 11 Leucyl-cystinyl aminopeptidase 7.3 0.5 9 Peroxiredoxin-1 8.0 0.7 19 Heterogeneous nuclear ribonucleoprotein Q 7.3 0.5 9 Peroxiredoxin-2 9.0 0.7 20 Calcineurin subunit B type 1 7.3 0.5 9 Peroxiredoxin-4 7.4 0.5 15 Histone H1x 7.3 0.6 9 Peroxiredoxin-5, mitochondrial 8.0 0.8 10 Fatty acid synthase 7.3 0.4 9 Peroxiredoxin-6 8.8 0.7 20 Rho-associated protein kinase 1 7.2 0.6 9 Peroxisomal acyl-coenzyme A oxidase 1 7.4 0.5 17 Vesicle-fusing ATPase 7.2 0.3 9 PEST proteolytic signal-containing nuclear protein 6.5 0.2 2 26S proteasome non-ATPase regulatory subunit 1 7.2 0.4 9 Phosphate carrier protein, mitochondrial 8.0 1 Septin-9 7.2 0.5 9 Phosphatidylcholine-sterol acyltransferase 6.9 0.5 10 N-myc-interactor 7.2 0.3 9 Phosphatidylethanolamine-binding protein 1 8.6 0.5 20 26S proteasome non-ATPase regulatory subunit 6 7.2 0.5 9 Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1 6.9 0.1 7 Complement factor H-related protein 1/2 7.1 0.6 9 Phosphatidylinositol 5-phosphate 4-kinase type-2 a/b 6.9 0.3 4 Ig kappa chain V-I region Kue 7.1 0.3 9 Phosphatidylinositol transfer protein a isoform 7.5 0.6 6 Rho GTPase-activating protein 4 7.1 0.6 9 Phosphatidylinositol transfer protein b isoform 6.9 0.8 7 Rho guanine nucleotide exchange factor 1 7.0 0.5 9 Phosphatidylinositol-binding clathrin assembly protein 7.4 0.4 6 Synaptotagmin-1 7.0 0.4 9 Phosphatidylinositol-glycan-specific phospholipase D 7.4 0.5 14 Apolipoprotein A 7.0 0.5 9 Phosphoglucomutase-1 8.1 0.5 18 N-formyl peptide receptor 2 7.0 0.5 9 Phosphoglucomutase-2 8.2 0.7 20 Copine-2 7.0 0.5 9 Phosphoglycerate kinase 1 9.2 0.6 20 Visinin-like protein 1 7.0 0.6 9 Phosphoglycerate mutase 1 9.0 0.5 20 Dihydropyrimidine dehydrogenase [NADP(+)] 6.9 0.3 9 Phospholipase B-like 1 9.0 0.4 20 Secernin-1 6.9 0.7 9 Phospholipid scramblase 1 7.4 0.2 4 Cytochrome b-c1 complex subunit 1, mitochondrial 6.9 0.6 9 Phospholipid transfer protein 7.7 0.8 18 Dynamin-2 6.9 0.7 9 Phospholysine phosphohistidine inorganic pyrophosphate phosphatase 7.6 0.5 17 Adiponectin 6.9 0.4 9 Phosphoprotein associated with glycosphingolipid-enriched microdomains 1 6.1 0.7 7 Serine/threonine-protein kinase OSR1 6.9 0.6 9 Phosphoribosyl pyrophosphate synthase-associated protein 2 6.2 0.2 6 Exportin-7 6.8 0.7 9 Pigment epithelium-derived factor 7.6 0.8 17 Carboxypeptidase B2 6.8 0.6 9 PITH domain-containing protein 1 7.4 0.5 12 Opioid growth factor receptor 6.8 0.4 9 Plasma kallikrein 7.6 0.6 20 MOB kinase activator 1A/B 6.7 0.5 9 Plasma protease C1 inhibitor 9.1 0.7 20 Ribosome-binding protein 1 6.6 0.6 9 Plasma serine protease inhibitor 7.5 0.7 14 UPF0556 protein C19orf10 6.6 0.3 9 Plasminogen 7.7 0.6 18 Eukaryotic translation initiation factor 2 subunit 1 6.6 0.4 9 Plasminogen activator inhibitor 1 6.8 0.6 18 Reticulon-1 6.5 0.4 9 Plastin-2 10.5 0.3 20 Valine--tRNA ligase 6.5 0.4 9 Platelet basic protein 7.2 0.7 12 Syntaxin-1B 6.5 0.5 9 Platelet glycoprotein Ib a chain 6.8 0.3 5 Epidermal growth factor receptor substrate 15-like 1 6.4 0.7 9 Platelet-activating factor acetylhydrolase IB subunit a 7.4 0.5 15 26S protease regulatory subunit 10B 7.8 0.4 8 Platelet-activating factor acetylhydrolase IB subunit b 7.9 0.6 18 Ubiquitin-like-conjugating enzyme ATG3 7.6 0.5 8 Platelet-activating factor acetylhydrolase IB subunit g 6.8 0.5 7 NEDD8 7.5 0.7 8 Pleckstrin 7.5 0.2 4 Ig lambda chain V-VI region WLT 7.5 0.4 8 Plectin 7.6 0.8 17 Carbonyl reductase [NADPH] 1/3 7.5 0.4 8 PML-RARA-regulated adapter molecule 1 7.1 0.7 8 Desmoglein-2 7.5 0.3 8 Poly(ADP-ribose) glycohydrolase ARH3 7.3 0.5 13 Ig kappa chain V-I region Mev 7.4 0.6 8 Polyadenylate-binding protein 1/3 7.5 0.8 9 ADP-ribosylation factor-like protein 8B 7.4 0.3 8 Polypyrimidine tract-binding protein 1 6.6 0.8 5 Carboxypeptidase N catalytic chain 7.4 0.8 8 Porphobilinogen deaminase 6.9 0.5 10 Prefoldin subunit 3 7.4 0.7 8 Pre-B-cell leukemia transcription factor-interacting protein 1 6.9 0.3 6 Glycogen debranching enzyme 7.4 0.5 8 Prefoldin subunit 2 7.3 0.3 12 Proteolipid protein 2 7.4 0.5 8 Prefoldin subunit 3 7.4 0.7 8 Dihydropteridine reductase 7.4 0.6 8 Prefoldin subunit 4 7.3 0.7 13 Vacuolar protein sorting-associated protein 26A 7.4 0.4 8 Prefoldin subunit 5 7.1 0.3 5 Neprilysin 7.4 0.6 8 Prefoldin subunit 6 7.1 0.4 7 Ig lambda variable 3-19 7.3 0.4 8 Pregnancy zone protein 6.8 0.7 8 Reticulon-3 7.3 0.4 8 Prelamin-A/C 7.4 0.7 15 Cullin-1 7.3 0.3 8 Pre-mRNA-processing-splicing factor 8 6.5 1 Cleavage and polyadenylation specificity factor subunit 5 7.3 0.4 8 Prenylcysteine oxidase 1 7.2 0.4 12 Reticulon-4 7.3 0.6 8 Procollagen C-endopeptidase enhancer 1 7.0 1 Mitogen-activated protein kinase 1 7.2 0.5 8 Profilin-1 9.5 0.6 20 Transmembrane emp24 domain-containing protein 10 7.2 0.6 8 Programmed cell death 6-interacting protein 7.8 0.8 19 Protein-arginine deiminase type-4 7.2 0.7 8 Programmed cell death protein 6 7.6 0.6 18 T-complex protein 1 subunit d 7.2 0.4 8 Prohibitin 7.7 0.4 2 Vacuolar protein sorting-associated protein 35 7.2 0.4 8 Prohibitin-2 6.3 0.3 4 Dynactin subunit 2 7.1 0.6 8 Interleukin-16/Pro-interleukin-16 5.9 0.7 4 Biotinidase 7.1 0.4 8 Proliferation-associated protein 2G4 7.1 0.5 12 PML-RARA-regulated adapter molecule 1 7.1 0.7 8 Prolyl endopeptidase 7.5 0.4 19 Cysteine--tRNA ligase, cytoplasmic 7.1 0.5 8 Prosaposin 8.3 0.7 20 Complement C1q subcomponent subunit C 7.1 0.7 8 Prostaglandin-H2 D-isomerase 7.7 0.7 13 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase g-2 7.0 0.5 8 Proteasome activator complex subunit 1 7.8 0.7 18 Structural maintenance of chromosomes protein 1A 7.0 0.5 8 Proteasome activator complex subunit 2 7.3 0.6 14 Tissue alpha-L-fucosidase 7.0 0.6 8 Proteasome subunit a type 8.3 0.3 19 Laminin subunit alpha-5 7.0 0.2 8 Proteasome subunit a type-1 8.9 0.4 20 Survival of motor neuron-related-splicing factor 30 6.9 0.5 8 Proteasome subunit a type-3 8.6 0.4 20 Methionine adenosyltransferase 2 subunit b 6.9 0.4 8 Proteasome subunit a type-7 9.0 0.4 20 Splicing factor, proline- and glutamine-rich 6.9 0.5 8 Proteasome subunit alpha type-2 8.8 0.6 20 Engulfment and cell motility protein 1/2 6.9 0.6 8 Proteasome subunit alpha type-4 8.4 0.6 20 26S protease regulatory subunit 6A 6.8 0.2 8 Proteasome subunit alpha type-5 8.9 0.5 20 Pregnancy zone protein 6.8 0.7 8 Proteasome subunit b type 8.2 0.4 20 Hematopoietic lineage cell-specific protein 6.7 0.9 8 Proteasome subunit b type-10 8.5 0.5 19 Serpin B3/B4 6.7 0.6 8 Proteasome subunit b type-2 8.8 0.6 20 ATP-dependent RNA helicase DDX39A 6.7 0.9 8 Proteasome subunit b type-4 8.1 0.4 20 26S proteasome non-ATPase regulatory subunit 9 6.6 0.5 8 Proteasome subunit b type-5 7.5 0.4 17 Dual specificity mitogen-activated protein kinase kinase 1 6.5 0.3 8 Proteasome subunit b type-6 8.1 0.2 19 Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2 7.9 0.6 7 Proteasome subunit b type-7 7.5 0.3 20 Myeloid-associated differentiation marker 7.7 0.6 7 Proteasome subunit b type-8 8.6 0.3 19 SUN domain-containing protein 2 7.7 0.7 7 Proteasome subunit beta type-1 8.9 0.4 20 Beta-actin-like protein 2 7.6 0.2 7 Proteasome subunit beta type-3 8.3 0.4 20 Inorganic pyrophosphatase 7.5 0.2 7 Protein 4.1 7.5 0.5 4 Erlin-1 7.5 0.7 7 Protein arginine N-methyltransferase 5 7.0 0.2 10 Cytochrome b-245 light chain 7.4 0.5 7 Protein argonaute-2 7.1 0.5 11 Ubiquitin carboxyl-terminal hydrolase isozyme L3 7.4 0.4 7 Protein canopy homolog 2 7.3 0.1 2 Formin-like protein 1 7.4 0.5 7 Protein canopy homolog 3 6.9 0.5 4 Pyruvate kinase PKLR 7.4 0.3 7 Protein CREG1 7.6 0.6 17 Complement component C8 gamma chain 7.4 0.4 7 Protein CutA 7.9 0.6 19 Alpha-centractin 7.4 0.5 7 Protein DDI1 homolog 2 6.7 0.8 6 Inositol polyphosphate 1-phosphatase 7.4 0.4 7 Protein DEK 7.1 0.5 7 Heterogeneous nuclear ribonucleoprotein F/H 7.3 0.1 7 Protein diaphanous homolog 1 7.3 0.9 15 Filamin-C 7.3 0.7 7 Protein disulfide-isomerase A3 8.0 0.8 20 WD repeat-containing protein 37 7.3 0.3 7 Protein disulfide-isomerase A4 7.3 0.8 16 Beta-Ala-His dipeptidase 7.3 0.3 7 Protein disulfide-isomerase A6 7.8 0.8 18 Aldehyde dehydrogenase, mitochondrial 7.3 0.9 7 Protein DJ-1 8.4 0.6 18 Endorepellin 7.3 0.9 7 Protein dpy-30 homolog 7.2 0.4 7 Interferon-induced transmembrane protein 1/2/3 7.2 0.3 7 Protein EVI2B 6.9 0.4 6 Calpain-2 catalytic subunit 7.2 0.6 7 Protein FAM107B 7.0 0.8 14 Protein dpy-30 homolog 7.2 0.4 7 Protein FAM49B 8.4 1.2 18 NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial 7.2 0.6 7 Protein Hook homolog 3 7.0 0.7 6 Splicing factor 3A subunit 1 7.2 0.4 7 Protein kinase C and casein kinase substrate in neurons protein 1 6.8 1.1 2 Prefoldin subunit 6 7.1 0.4 7 Protein kinase C and casein kinase substrate in neurons protein 2 7.7 0.6 19 NAD-dependent malic enzyme, mitochondrial 7.1 0.8 7 Protein NDRG2 7.2 0.5 4 Fatty acid-binding protein, heart 7.1 0.4 7 Protein Niban 6.9 0.4 4 Secernin-2 7.1 0.5 7 Protein phosphatase 1 regulatory subunit 12A 7.3 0.4 16 Calpastatin 7.1 0.7 7 Protein phosphatase 1 regulatory subunit 14A 7.2 0.3 5 Protein DEK 7.1 0.5 7 Protein phosphatase 1 regulatory subunit 7 7.2 0.2 10 Mannose-1-phosphate guanyltransferase b 7.0 0.3 7 Protein phosphatase 1A/B 7.3 0.5 10 Cytoskeleton-associated protein 4 7.0 0.8 7 Protein S100-A1 7.9 0.5 16 NHL repeat-containing protein 3 7.0 0.5 7 Protein S100-A11 8.9 0.5 20 14-3-3 protein sigma 7.0 0.7 7 Protein S100-A12 9.7 0.7 20 Cholinesterase 7.0 0.4 7 Protein S100-A13 7.3 0.4 10 T-complex protein 1 subunit g 7.0 0.7 7 Protein S100-A4 9.0 0.4 20 Ribonuclease UK114 7.0 0.2 7 Protein S100-A6 8.8 0.4 20 Phosphatidylinositol transfer protein b isoform 6.9 0.8 7 Protein S100-A8 10.8 0.2 20 Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1 6.9 0.1 7 Protein S100-A9 11.5 0.3 20 40S ribosomal protein SA 6.9 0.3 7 Protein S100-B 7.9 0.8 16 Alpha-internexin 6.9 0.5 7 Protein S100-P 9.4 0.3 20 Cytokine receptor-like factor 3 6.9 0.4 7 Protein SET 8.7 0.5 20 Platelet-activating factor acetylhydrolase IB subunit g 6.8 0.5 7 Protein TFG 7.6 0.2 3 3-ketoacyl-CoA thiolase, mitochondrial 6.8 0.4 7 Protein unc-13 homolog D 7.2 0.3 12 Glutamine-dependent NAD(+) synthetase 6.8 0.4 7 Protein XRP2 7.6 0.5 17 Nucleosome assembly protein 1-like 4 6.8 0.6 7 Protein Z-dependent protease inhibitor 7.2 0.5 3 Ketosamine-3-kinase 6.8 0.7 7 Protein-arginine deiminase type-2 7.3 0.8 15 Vasorin 6.8 0.6 7 Protein-arginine deiminase type-4 7.2 0.7 8 4F2 cell-surface antigen heavy chain 6.7 0.6 7 Protein-glutamine gamma-glutamyltransferase 2 6.0 0.4 3 Cathepsin L1 6.7 0.6 7 Protein-L-isoaspartate O-methyltransferase 7.3 0.5 11 Heme oxygenase 2 6.6 0.3 7 Protein-methionine sulfoxide oxidase MICAL1 7.4 0.2 2 Calmodulin-like protein 5 6.6 0.8 7 Proteoglycan 4 7.4 1.1 16 Ubiquitin-conjugating enzyme E2 G1 6.5 0.3 7 Proteolipid protein 2 7.4 0.5 8 Amyloid beta A4 protein 6.4 0.4 7 Prothrombin 7.4 0.5 17 Prothymosin alpha 6.3 0.7 7 Prothymosin alpha 6.3 0.7 7 Cullin-4B 6.1 0.2 7 Pterin-4-alpha-carbinolamine dehydratase 7.4 0.5 20 Phosphoprotein associated with glycosphingolipid-enriched microdomains 1 6.1 0.7 7 Purine nucleoside phosphorylase 9.2 0.6 20 Cysteine-rich secretory protein 3 6.1 0.7 7 Puromycin-sensitive aminopeptidase 8.5 0.5 20 Monocyte differentiation antigen CD14 7.8 0.5 6 Putative deoxyribose-phosphate aldolase 7.4 0.5 12 Voltage-dependent anion-selective channel protein 1 7.7 0.8 6 Putative GTP cyclohydrolase 1 type 2 NIF3L1 7.3 0.4 16 Elongation factor 1-a 1/2 7.7 0.8 6 Putative nucleoside diphosphate kinase 7.3 0.2 11 Ras-related protein Rab-27A 7.6 0.6 6 Pyridoxal kinase 7.6 0.5 10 Solute carrier family 2, facilitated glucose transporter member 3/14 7.6 0.6 6 Pyridoxal phosphate phosphatase 7.0 0.5 11 Sulfide:quinone oxidoreductase, mitochondrial 7.5 0.4 6 Pyruvate kinase (PKM2) 7.4 0.4 15 Phosphatidylinositol transfer protein a isoform 7.5 0.6 6 Pyruvate kinase (PKM3) 9.1 0.5 20 Phosphatidylinositol-binding clathrin assembly protein 7.4 0.4 6 Pyruvate kinase PKLR 7.4 0.3 7 Lamin-B receptor 7.4 0.6 6 Quinone oxidoreductase PIG3 7.6 0.4 18 Ubiquitin-like modifier-activating enzyme ATG7 7.3 0.5 6 Rab GDP dissociation inhibitor a 8.3 0.5 17 Choline transporter-like protein 2 7.3 0.2 6 Rab GDP dissociation inhibitor beta 9.3 0.4 19 Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit Aa isoform 7.3 0.6 6 Radixin 7.2 1 COMM domain-containing protein 9 7.3 0.2 6 Ragulator complex protein LAMTOR3 7.5 0.6 14 DnaJ homolog subfamily C member 13 7.3 0.4 6 Ragulator complex protein LAMTOR5 7.7 0.4 15 Hypoxia up-regulated protein 1 7.2 0.3 6 Ran-binding protein 6 6.5 1 Myelin P2 protein 7.1 0.5 6 Ran-specific GTPase-activating protein 7.2 0.1 3 Kinesin-1 heavy chain 7.1 0.5 6 Ras GTPase-activating-like protein IQGAP1 9.2 0.4 20 Aconitate hydratase, mitochondrial 7.1 0.9 6 Ras GTPase-activating-like protein IQGAP2 6.4 0.4 4 TBC1 domain family member 1 7.1 0.5 6 RAS protein activator like-3 7.2 0.3 17 Coatomer subunit b 7.1 0.5 6 Ras suppressor protein 1 7.1 0.7 15 Mannosyl-oligosaccharide glucosidase 7.1 0.4 6 Ras-related C3 botulinum toxin substrate 2 7.9 0.5 10 T-complex protein 1 subunit epsilon 7.0 0.7 6 Ras-related protein Rab-10 7.3 0.6 17 Thiosulfate sulfurtransferase 7.0 0.4 6 Ras-related protein Rab-11 7.8 0.7 20 NAD-dependent protein deacetylase sirtuin-2 7.0 0.7 6 Ras-related protein Rab-1A/B 7.3 0.9 17 Protein Hook homolog 3 7.0 0.7 6 Ras-related protein Rab-21 7.3 0.5 15 Splicing factor 1 7.0 0.4 6 Ras-related protein Rab-27A 7.6 0.6 6 Protein EVI2B 6.9 0.4 6 Ras-related protein Rab-2A 7.2 0.4 10 Laminin subunit alpha-4 6.9 0.4 6 Ras-related protein Rab-31 7.4 1 Delta(3,5)-Delta(2,4)-dienoyl-CoA isomerase, mitochondrial 6.9 0.5 6 Ras-related protein Rab-3D 7.5 1 T-complex protein 1 subunit zeta 6.9 0.6 6 Ras-related protein Rab-43 7.3 1 Pre-B-cell leukemia transcription factor-interacting protein 1 6.9 0.3 6 Ras-related protein Rab-5A/B 7.3 0.3 5 High mobility group protein HMG-I/HMG-Y 6.9 0.5 6 Ras-related protein Rab-5C 7.5 0.5 17 Fructose-1,6-bisphosphatase isozyme 2 6.9 0.2 6 Ras-related protein Rab-7a 8.4 0.4 18 Extracellular matrix protein 1 6.9 0.7 6 Ras-related protein Rab-8A 6.7 0.5 10 Collagen alpha-2(IV) chain 6.9 0.4 6 Ras-related protein Rab-8B 7.0 0.6 19 Glutathione S-transferase Mu 2/4 6.8 0.3 6 Ras-related protein Rap-1b 7.9 0.5 15 Sex hormone-binding globulin 6.8 0.8 6 Ras-related protein Rap-2b 6.6 0.4 4 Collagen alpha-2(I) chain 6.8 0.4 6 Receptor-type tyrosine-protein phosphatase C 7.9 0.7 18 CapZ-interacting protein 6.7 0.8 6 Receptor-type tyrosine-protein phosphatase eta 7.4 0.5 14 Syntaxin-1A 6.7 0.9 6 Resistin 8.7 0.5 20 Protein DDI1 homolog 2 6.7 0.8 6 Reticulon-1 6.5 0.4 9 Charged multivesicular body protein 4b 6.5 0.3 6 Reticulon-3 7.3 0.4 8 High affinity immunoglobulin epsilon receptor subunit g 6.5 0.5 6 Reticulon-4 7.3 0.6 8 Eukaryotic translation initiation factor 3 subunit J 6.5 0.6 6 Retinal dehydrogenase 1 7.5 0.7 15 Syntaxin-binding protein 1 6.2 0.4 6 Retinoblastoma-like protein 1 8.3 0.8 17 MARCKS-related protein 6.2 0.4 6 Retinol-binding protein 4 7.7 0.8 17 Phosphoribosyl pyrophosphate synthase-associated protein 2 6.2 0.2 6 Rho GDP-dissociation inhibitor 1 8.1 0.6 20 Gamma-synuclein 5.8 0.5 6 Rho GDP-dissociation inhibitor 2 8.8 0.5 20 Histone H2A type 1-B/C/E/type 3 8.4 0.3 5 Rho GTPase-activating protein 1 7.2 0.8 13 Syndecan-1 8.0 0.7 5 Rho GTPase-activating protein 25 7.2 0.5 18 Parvalbumin alpha 7.8 0.5 5 Rho GTPase-activating protein 30 6.0 0.2 3 Tubulin beta-4A chain 7.8 0.7 5 Rho GTPase-activating protein 4 7.1 0.6 9 Synaptophysin-like protein 1 7.7 0.6 5 Rho GTPase-activating protein 9 7.3 0.4 4 Calbindin 7.5 1.0 5 Rho guanine nucleotide exchange factor 1 7.0 0.5 9 CD44 antigen 7.4 0.4 5 Rho-associated protein kinase 1 7.2 0.6 9 Aspartyl aminopeptidase 7.4 0.3 5 Rho-related GTP-binding protein RhoG 7.3 0.2 10 Myc box-dependent-interacting protein 1 7.4 0.2 5 Ribonuclease inhibitor 7.6 0.5 14 Coagulation factor XII 7.4 0.8 5 Ribonuclease T2 8.2 0.5 20 Long-chain enoyl-CoA hydratase/Long chain 3-hydroxyacyl-CoA dehydrogenase 7.4 0.5 5 Ribonuclease UK114 7.0 0.2 7 CD97 antigen 7.4 0.4 5 Ribose-5-phosphate isomerase 7.7 0.5 20 Cytoplasmic dynein 1 heavy chain 1 7.4 0.5 5 Ribose-phosphate pyrophosphokinase 1 6.8 0.4 11 Succinate dehydrogenase [ubiquinone] flavoprotein subunit 7.4 0.4 5 Ribosome-binding protein 1 6.6 0.6 9 Collagen alpha-1(V) chain 7.3 0.4 5 Ribosyldihydronicotinamide dehydrogenase [quinone] 7.5 0.5 19 Ras-related protein Rab-5A/B 7.3 0.3 5 Ribulose-phosphate 3-epimerase 7.9 0.5 19 Acidic leucine-rich nuclear phosphoprotein 32 family member E 7.3 0.2 5 RNA-binding motif protein, X chromosome 7.2 0.7 18 Ig kappa chain V-II region FR 7.3 0.6 5 RNA-binding protein EWS 7.4 0.4 15 Heterogeneous nuclear ribonucleoprotein L 7.3 0.2 5 RNA-binding protein FUS 7.0 0.2 4 Epididymis-specific alpha-mannosidase 7.3 0.2 5 RuvB-like 2 6.7 0.4 2 Nck-associated protein 1-like 7.3 0.3 5 S-adenosylmethionine synthase isoform type-2 7.4 0.5 14 Torsin-1A-interacting protein 1 7.3 0.4 5 Scavenger receptor cysteine-rich type 1 protein M130/Soluble CD163 6.2 1 Signal transducing adapter molecule 1 7.2 0.4 5 Sec1 family domain-containing protein 1 8.1 0.5 19 5-nucleotidase domain-containing protein 1 7.2 0.3 5 Secernin-1 6.9 0.7 9 Serum paraoxonase/lactonase 3 7.2 0.4 5 Secernin-2 7.1 0.5 7 Transmembrane emp24 domain-containing protein 9 7.2 0.3 5 Selenium-binding protein 1 8.4 0.4 20 Protein phosphatase 1 regulatory subunit 14A 7.2 0.3 5 Selenoprotein P 7.1 0.8 3 Tubulin beta-2A/2B chain 7.2 1.0 5 Septin-7 7.2 0.3 10 Nascent polypeptide-associated complex subunit a 7.2 0.4 5 Septin-9 7.2 0.5 9 Alpha-crystallin B chain 7.2 0.6 5 Serine protease 57 7.3 0.0 3 Interleukin-1 receptor-like 1 7.2 0.2 5 Serine/arginine repetitive matrix protein 1 7.3 0.6 15 Trypsin-3 7.2 0.4 5 Serine/arginine-rich splicing factor 3 7.1 0.5 10 Guanine nucleotide-binding protein subunit g 7.1 0.4 5 Serine/threonine-protein kinase 4 7.4 0.6 9 Prefoldin subunit 5 7.1 0.3 5 Serine/threonine-protein kinase OSR1 6.9 0.6 9 Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit Ab Guanine nucleotide-binding protein G(o) subunit a 7.1 0.6 5 isoform 7.4 1 SNARE-associated protein Snapin 7.1 0.7 5 Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit Aa 7.3 0.6 6 isoform Syntaxin-12 7.1 0.2 5 Serine/threonine-protein phosphatase 2A activator 7.6 0.6 19 Lysine--tRNA ligase 7.1 0.2 5 Serine/threonine-protein phosphatase 2A catalytic subunit a/b isoform 7.3 0.4 2 Surfeit locus protein 4 7.1 0.4 5 Serine/threonine-protein phosphatase CPPED1 8.5 0.3 20 Guanine deaminase 7.1 0.3 5 Serotransferrin 10.1 0.6 20 Diphosphoinositol polyphosphate phosphohydrolase 1 7.1 0.3 5 Serpin B10 9.2 0.4 20 Serpin B5 6.8 0.5 5 Serpin B3/B4 6.7 0.6 8 Platelet glycoprotein Ib a chain 6.8 0.3 5 Serpin B5 6.8 0.5 5 T-complex protein 1 subunit a 6.7 0.4 5 Serpin B6 8.2 0.4 20 Tenascin-R 6.7 0.7 5 Serpin B8 7.5 0.4 20 Insulin-like growth factor-binding protein 3 6.7 0.3 5 Serpin B9 7.4 0.3 4 Acetyl-CoA acetyltransferase, mitochondrial 6.6 0.5 5 Serum albumin 11.4 0.4 20 Polypyrimidine tract-binding protein 1 6.6 0.8 5 Serum amyloid A-1 protein 7.8 1.1 14 Electron transfer flavoprotein subunit b 6.6 0.1 5 Serum amyloid A-2 protein 7.6 0.9 3 Chromogranin-A 6.5 0.6 5 Serum amyloid A-4 protein 7.4 0.7 12 ATP-binding cassette sub-family B member 6, mitochondrial 6.5 0.6 5 Serum amyloid P-component 8.1 0.6 20 Alpha-synuclein 6.3 0.7 5 Serum paraoxonase/arylesterase 1 7.9 0.8 14 Wiskott-Aldrich syndrome protein 6.3 0.8 5 Serum paraoxonase/lactonase 3 7.2 0.4 5 Cytochrome c oxidase subunit 5A, mitochondrial 8.2 0.3 4 Sex hormone-binding globulin 6.8 0.8 6 Glutathione S-transferase kappa 1 8.0 0.5 4 S-formylglutathione hydrolase 7.4 0.5 13 Activated RNA polymerase II transcriptional coactivator p15 7.9 0.2 4 SH3 domain-binding glutamic acid-rich-like protein 8.6 0.3 20 Voltage-dependent anion-selective channel protein 3 7.8 0.4 4 SH3 domain-binding glutamic acid-rich-like protein 3 8.7 0.4 20 Thioredoxin-related transmembrane protein 4 7.8 0.3 4 Sialic acid synthase 6.8 0.7 15 Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3B 7.7 0.3 4 Sialic acid-binding Ig-like lectin 5/14 7.2 0.2 4 3-Ketoacyl-CoA thiolase 7.6 0.5 4 Sideroflexin-1 7.3 0.3 2 Mitochondrial 2-oxoglutarate/malate carrier protein 7.5 0.6 4 Signal recognition particle 14 kDa protein 7.6 0.5 9 Protein 4.1 7.5 0.5 4 Signal recognition particle 9 kDa protein 7.1 0.4 12 Pleckstrin 7.5 0.2 4 Signal transducing adapter molecule 1 7.2 0.4 5 Erlin-2 7.4 0.3 4 Small glutamine-rich tetratricopeptide repeat-containing protein a 7.6 0.5 10 Hydroxyacylglutathione hydrolase, mitochondrial 7.4 0.3 4 Small nuclear ribonucleoprotein E 7.4 0.5 16 Serpin B9 7.4 0.3 4 Small nuclear ribonucleoprotein Sm D2 7.0 0.4 17 Phospholipid scramblase 1 7.4 0.2 4 Small ubiquitin-related modifier 1 6.3 0.4 11 Liver carboxylesterase 1 7.4 0.3 4 Small ubiquitin-related modifier 2/3/4 7.2 0.5 11 Hydroxysteroid dehydrogenase-like protein 2 7.4 0.4 4 S-methyl-5-thioadenosine phosphorylase 8.0 0.5 14 Glycerol-3-phosphate dehydrogenase, mitochondrial 7.3 0.5 4 Smoothelin-like protein 2 8.7 0.4 14 Integrin beta-1 7.3 0.2 4 SNARE-associated protein Snapin 7.1 0.7 5 Calcium uniporter protein, mitochondrial 7.3 0.3 4 Sodium/potassium-transporting ATPase subunit a-1 7.5 0.8 14 Mannose-binding protein C 7.3 0.1 4 Sodium/potassium-transporting ATPase subunit a-3 7.6 0.5 2 Collagen alpha-1(VII) chain 7.3 0.6 4 Sodium/potassium-transporting ATPase subunit b-1 7.5 0.6 10 Ig heavy chain V-I region HG3 7.3 0.2 4 Solute carrier family 2, facilitated glucose transporter member 1 7.2 0.7 10 Rho GTPase-activating protein 9 7.3 0.4 4 Solute carrier family 2, facilitated glucose transporter member 3/14 7.6 0.6 6 Unconventional myosin-XVIIIa 7.2 0.3 4 Sorcin 6.7 0.4 12 Protein NDRG2 7.2 0.5 4 SPARC 6.7 0.2 4 Sialic acid-binding Ig-like lectin 5/14 7.2 0.2 4 SPARC-like protein 1 6.4 1 Heterochromatin protein 1-binding protein 3 7.2 0.4 4 Spectrin alpha chain, erythrocytic 1 8.2 0.6 20 Ig heavy chain V-I region EU 7.2 0.4 4 Spectrin alpha chain, non-erythrocytic 1 9.1 0.5 20 COP9 signalosome complex subunit 3 7.1 0.8 4 Spectrin beta chain, erythrocytic 8.1 0.5 19 Tumor protein D52 7.1 0.4 4 Spectrin beta chain, non-erythrocytic 1 8.5 0.5 20 Ig heavy chain V-III region ZAP 7.1 0.5 4 S-phase kinase-associated protein 1 7.1 0.5 13 Cytochrome c oxidase subunit 4 isoform 1, mitochondrial 7.1 1.0 4 Splicing factor 1 7.0 0.4 6 Choline/ethanolamine kinase 7.1 0.3 4 Splicing factor 3A subunit 1 7.2 0.4 7 Ig heavy chain V-III region GAR 7.0 0.4 4 Splicing factor U2AF 65 kDa subunit 7.7 0.6 15 RNA-binding protein FUS 7.0 0.2 4 Splicing factor, proline- and glutamine-rich 6.9 0.5 8 Wiskott-Aldrich syndrome protein family member 2 7.0 0.4 4 Squamous cell carcinoma antigen recognized by T-cells 3 6.1 0.5 4 Protein canopy homolog 3 6.9 0.5 4 Src kinase-associated phosphoprotein 2 7.0 0.4 10 Ig heavy variable 3-64 6.9 0.4 4 Stathmin 7.9 0.3 18 Transferrin receptor protein 1, serum form 6.9 0.4 4 STE20-like serine/threonine-protein kinase 6.5 0.4 3 Vitamin K-dependent protein Z 6.9 0.4 4 Stress-70 protein, mitochondrial 7.7 0.2 2 Phosphatidylinositol 5-phosphate 4-kinase type-2 a/b 6.9 0.3 4 Stress-induced-phosphoprotein 1 7.5 0.5 16 Cullin-2 6.9 0.2 4 Structural maintenance of chromosomes protein 1A 7.0 0.5 8 Transcription initiation factor TFIID subunit 6 6.9 0.4 4 Structural maintenance of chromosomes protein 3 6.8 1 Tubulin polymerization-promoting protein 6.9 0.4 4 Succinate dehydrogenase [ubiquinone] flavoprotein subunit 7.4 0.4 5 Protein Niban 6.9 0.4 4 Sulfhydryl oxidase 1 7.7 0.4 19 Alpha/beta-soluble NSF attachment protein 6.8 0.2 4 Sulfide:quinone oxidoreductase, mitochondrial 7.5 0.4 6 Follistatin-related protein 1 6.7 0.6 4 SUN domain-containing protein 2 7.7 0.7 7 UMP-CMP kinase 6.7 0.5 4 Superoxide dismutase [Cu-Zn] 8.0 0.8 19 SPARC 6.7 0.2 4 Superoxide dismutase [Mn], mitochondrial 9.2 0.5 20 Glycine cleavage system H protein, mitochondrial 6.6 0.5 4 Surfeit locus protein 4 7.1 0.4 5 Non-specific lipid-transfer protein 6.6 0.5 4 Survival of motor neuron-related-splicing factor 30 6.9 0.5 8 Ras-related protein Rap-2b 6.6 0.4 4 Synapsin-1 6.2 0.6 4 26S proteasome non-ATPase regulatory subunit 11 6.6 0.6 4 Synaptic vesicle membrane protein VAT-1 homolog 8.3 0.6 19 Alpha-hemoglobin-stabilizing protein 6.5 0.7 4 Synaptophysin-like protein 1 7.7 0.6 5 Fascin 6.5 0.6 4 Synaptosomal-associated protein 23 7.4 0.5 13 Ras GTPase-activating-like protein IQGAP2 6.4 0.4 4 Synaptosomal-associated protein 25 7.4 0.4 3 Intercellular adhesion molecule 1 6.4 0.5 4 Synaptotagmin-1 7.0 0.4 9 Beta-2-microglobulin 6.4 0.5 4 Syndecan-1 8.0 0.7 5 Complement C1r subcomponent-like protein 6.4 0.7 4 Syntaxin-12 7.1 0.2 5 Prohibitin-2 6.3 0.3 4 Syntaxin-1A 6.7 0.9 6 Synapsin-1 6.2 0.6 4 Syntaxin-1B 6.5 0.5 9 MAP7 domain-containing protein 1 6.2 0.3 4 Syntaxin-3 7.1 0.5 16 7,8-dihydro-8-oxoguanine triphosphatase 6.1 0.2 4 Syntaxin-7 7.6 0.3 15 Squamous cell carcinoma antigen recognized by T-cells 3 6.1 0.5 4 Syntaxin-binding protein 1 6.2 0.4 6 Transmembrane emp24 domain-containing protein 2 6.0 0.5 4 Syntaxin-binding protein 2 6.7 0.5 13 14-3-3 protein e 5.9 0.7 4 Syntenin-1 8.2 0.5 20 Protein TFG 7.6 0.2 3 Talin-1 9.4 0.4 20 Serum amyloid A-2 protein 7.6 0.9 3 Target of Myb protein 1 7.4 0.3 10 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9 7.6 0.4 3 Target of Nesh-SH3 6.6 1 DNA-binding protein RFX7 7.5 0.3 3 TBC1 domain family member 1 7.1 0.5 6 ATP synthase subunit O, mitochondrial 7.5 0.3 3 T-complex protein 1 subunit a 6.7 0.4 5 Dehydrogenase/reductase SDR family member 7 7.5 0.3 3 T-complex protein 1 subunit b 7.4 0.6 16 Tubulin beta-3 chain 7.5 0.3 3 T-complex protein 1 subunit d 7.2 0.4 8 Synaptosomal-associated protein 25 7.4 0.4 3 T-complex protein 1 subunit epsilon 7.0 0.7 6 ATP synthase subunit d, mitochondrial 7.4 0.6 3 T-complex protein 1 subunit eta 6.9 0.6 13 Apolipoprotein F 7.4 0.6 3 T-complex protein 1 subunit g 7.0 0.7 7 Thrombospondin-2 7.4 0.3 3 T-complex protein 1 subunit theta 7.6 0.5 14 Tumor necrosis factor alpha-induced protein 8 7.4 0.4 3 T-complex protein 1 subunit zeta 6.9 0.6 6 Dolichyl-diphosphooligosaccharide--protein glycosyltransferase 48 kDa subunit 7.4 0.4 3 Tenascin 7.9 0.7 19 Serine protease 57 7.3 0.0 3 Tenascin-R 6.7 0.7 5 Interstitial collagenase 7.3 0.3 3 Thioredoxin 9.2 0.4 20 Nuclear receptor-interacting protein 1 7.3 0.4 3 Thioredoxin domain-containing protein 17 7.6 0.5 16 GTP cyclohydrolase 1 feedback regulatory protein 7.3 0.3 3 Thioredoxin reductase 1, cytoplasmic 8.0 0.3 19 HLA class I histocompatibility antigen, Cw-14 a chain 7.3 0.1 3 Thioredoxin-dependent peroxide reductase, mitochondrial 7.4 0.7 19 ATPase ASNA1 7.3 0.1 3 Thioredoxin-like protein 1 7.0 0.4 10 26S protease regulatory subunit 7 7.2 0.5 3 Thioredoxin-related transmembrane protein 1 7.2 0.5 11 Ran-specific GTPase-activating protein 7.2 0.1 3 Thioredoxin-related transmembrane protein 4 7.8 0.3 4 Protein Z-dependent protease inhibitor 7.2 0.5 3 Thiosulfate sulfurtransferase 7.0 0.4 6 Beta-adducin 7.2 0.6 3 THO complex subunit 4 7.6 0.4 17 MICOS complex subunit MIC60 7.1 0.2 3 Thrombospondin-2 7.4 0.3 3 Coagulation factor XIII B chain 7.1 0.4 3 Thymidine phosphorylase 8.1 0.8 18 Tyrosine--tRNA ligase, cytoplasmic 7.1 0.4 3 Thymopoietin 7.4 0.5 10 Ig kappa chain V-I region HK101 7.1 0.3 3 Thymosin b-4 8.3 0.6 20 Selenoprotein P 7.1 0.8 3 Thymosin beta-10 7.5 1 Collagen alpha-1(VI) chain 7.1 0.6 3 Thyroxine-binding globulin 7.6 0.5 19 Cadherin-5 7.1 0.0 3 Tissue alpha-L-fucosidase 7.0 0.6 8 Delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial 7.1 0.6 3 Tissue-type plasminogen activator 7.7 1 26S proteasome non-ATPase regulatory subunit 5 7.0 0.3 3 Toll-interacting protein 7.4 0.4 15 Fetuin-B 7.0 0.6 3 Torsin-1A-interacting protein 1 7.3 0.4 5 HLA class II histocompatibility antigen, DRB1-8/11 b chain 7.0 0.4 3 Torsin-4A 6.7 1 Hepatoma-derived growth factor-related protein 2 7.0 0.2 3 Transaldolase 9.6 0.3 20 Ubiquitin carboxyl-terminal hydrolase 5 7.0 0.3 3 Transcobalamin-1 7.6 0.4 18 V-type proton ATPase subunit D 6.9 0.5 3 Transcription elongation factor A protein-like 5 6.3 1 Acetyl-CoA acetyltransferase, cytosolic 6.9 0.4 3 Transcription factor 20 7.7 0.3 10 C-type lectin domain family 11 member A 6.9 0.1 3 Transcription initiation factor IIA subunit 1 7.2 0.5 14 Calsyntenin-1 6.9 0.9 3 Transcription initiation factor TFIID subunit 6 6.9 0.4 4 Melanoma inhibitory activity protein 3 6.8 0.5 3 Transferrin receptor protein 1, serum form 6.9 0.4 4 C-Myc-binding protein 6.8 0.2 3 Transforming growth factor-b-induced protein ig-h3 7.4 0.5 19 Hepatocyte growth factor-like protein 6.8 0.1 3 Transforming protein RhoA/B/C 7.7 0.5 14 Alkaline phosphatase, tissue-nonspecific isozyme 6.8 0.3 3 Transgelin 7.3 0.7 10 CB1 cannabinoid receptor-interacting protein 1 6.7 0.7 3 Transgelin-2 8.4 0.5 20 Collagen alpha-2(V) chain 6.7 0.2 3 Transitional endoplasmic reticulum ATPase 8.5 0.7 20 Neural cell adhesion molecule 1 6.7 0.4 3 Transketolase 9.8 0.4 20 Lupus La protein 6.6 0.1 3 Translationally-controlled tumor protein 7.1 0.5 17 Ig kappa chain V-I region CAR 6.5 0.6 3 Translin 8.5 0.5 20 STE20-like serine/threonine-protein kinase 6.5 0.4 3 Translin-associated protein X 7.7 0.4 20 V-type proton ATPase subunit G 2 6.3 0.3 3 Transmembrane emp24 domain-containing protein 10 7.2 0.6 8 F-box only protein 7 6.3 0.3 3 Transmembrane emp24 domain-containing protein 2 6.0 0.5 4 Dopamine beta-hydroxylase 6.3 0.7 3 Transmembrane emp24 domain-containing protein 9 7.2 0.3 5 Caspase-14 6.2 0.4 3 Transthyretin 10.2 0.4 20 E2/E3 hybrid ubiquitin-protein ligase UBE2O 6.0 0.6 3 Triosephosphate isomerase 9.7 0.5 20 Protein-glutamine gamma-glutamyltransferase 2 6.0 0.4 3 Tripeptidyl-peptidase 1 7.6 0.0 2 Rho GTPase-activating protein 30 6.0 0.2 3 Tripeptidyl-peptidase 2 7.1 0.4 12 Methylenetetrahydrofolate dehydrogenase 5.9 0.3 3 Tropomodulin-1 6.7 0.2 2 Acylphosphatase-2 5.7 0.3 3 Tropomodulin-3 7.6 0.7 13 Cytochrome c1, heme protein, mitochondrial 8.0 0.1 2 Tropomyosin alpha-1 chain 7.0 0.6 17 DnaJ homolog subfamily B member 11 7.9 0.2 2 Trypsin-3 7.2 0.4 5 Agrin 7.8 0.8 2 Trypstatin 8.1 0.7 19 Osteopontin 7.7 0.1 2 Tryptophan--tRNA ligase, cytoplasmic 8.2 0.6 19 Heterogeneous nuclear ribonucleoprotein U 7.7 0.2 2 Tubulin a-1C chain 8.1 0.9 19 Stress-70 protein, mitochondrial 7.7 0.2 2 Tubulin alpha-3C/D/E chain 7.9 0.9 11 Elongation factor Tu, mitochondrial 7.7 0.1 2 Tubulin b-4B chain 8.1 0.7 19 Prohibitin 7.7 0.4 2 Tubulin beta chain 7.6 0.9 18 Sodium/potassium-transporting ATPase subunit a-3 7.6 0.5 2 Tubulin beta-2A/2B chain 7.2 1.0 5 Histone H1.2 7.6 0.7 2 Tubulin beta-3 chain 7.5 0.3 3 Tripeptidyl-peptidase 1 7.6 0.0 2 Tubulin beta-4A chain 7.8 0.7 5 Cytochrome b-c1 complex subunit 2, mitochondrial 7.6 0.0 2 Tubulin polymerization-promoting protein 6.9 0.4 4 Laminin subunit g-2 7.6 0.1 2 Tubulin-specific chaperone A 7.8 0.5 16 NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial 7.5 0.1 2 Tumor necrosis factor alpha-induced protein 8 7.4 0.4 3 Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit DAD1 7.4 0.1 2 Tumor protein D52 7.1 0.4 4 Integral membrane protein 2B 7.4 0.3 2 Tumor protein D54 7.8 0.4 17 Exportin-1 7.4 0.4 2 Tumor-associated calcium signal transducer 2 7.7 1 NADH dehydrogenase [ubiquinone] 1 a subcomplex subunit 10, mitochondrial 7.4 0.2 2 Twinfilin-1 6.7 0.4 17 Ig kappa chain V-II region RPMI 6410 7.4 0.1 2 Twinfilin-2 8.1 0.6 18 Tyrosine-protein kinase HCK/Fyn/Yes/Proto-oncogene tyrosine-protein kinase Protein-methionine sulfoxide oxidase MICAL1 7.4 0.2 2 Src 7.4 0.5 13 Sideroflexin-1 7.3 0.3 2 Tyrosine-protein phosphatase non-receptor type 11 6.9 0.4 11 Serine/threonine-protein phosphatase 2A catalytic subunit a/b isoform 7.3 0.4 2 Tyrosine-protein phosphatase non-receptor type 6 7.8 0.7 18 Ig kappa chain V-I region HK102 7.3 0.1 2 Tyrosine-protein phosphatase non-receptor type substrate 1 7.6 0.4 20 Protein canopy homolog 2 7.3 0.1 2 Tyrosine--tRNA ligase, cytoplasmic 7.1 0.4 3 Nuclear pore membrane glycoprotein 210 7.3 0.6 2 U6 snRNA-associated Sm-like protein LSm8 7.5 0.6 16 Hexokinase-1 7.2 0.5 2 Ubiquilin-1 7.2 0.4 10 Hemoglobin subunit mu 7.2 0.5 2 Ubiquilin-2 5.2 1 Complement C1q subcomponent subunit A 7.2 0.3 2 Ubiquitin carboxyl-terminal hydrolase 6.9 0.4 12 Biliverdin reductase A 7.1 0.5 2 Ubiquitin carboxyl-terminal hydrolase 15 7.3 0.5 13 Cholesteryl ester transfer protein 7.0 0.1 2 Ubiquitin carboxyl-terminal hydrolase 5 7.0 0.3 3 Ig lambda chain V-VI region AR 7.0 0.2 2 Ubiquitin carboxyl-terminal hydrolase isozyme L1 7.5 0.4 12 Beta-centractin 6.9 0.2 2 Ubiquitin carboxyl-terminal hydrolase isozyme L3 7.4 0.4 7 Importin-7 6.9 0.3 2 Ubiquitin thioesterase OTU1 7.1 1 Myosin-6 6.9 0.3 2 Ubiquitin thioesterase OTUB1 7.7 0.6 18 CTP synthase 1 6.9 0.5 2 Ubiquitin-60S ribosomal protein L40 9.5 0.3 20 Complement receptor type 1 6.9 0.0 2 Ubiquitin-conjugating enzyme E2 G1 6.5 0.3 7 Guanine nucleotide-binding protein G(q) subunit a 6.8 0.1 2 Ubiquitin-conjugating enzyme E2 K 7.3 0.3 13 AP-2 complex subunit a-1/2 6.8 0.2 2 Ubiquitin-conjugating enzyme E2 L3 7.2 0.9 16 Protein kinase C and casein kinase substrate in neurons protein 1 6.8 1.1 2 Ubiquitin-conjugating enzyme E2 N 8.1 0.6 18 Nitric oxide synthase, inducible 6.8 0.6 2 Ubiquitin-conjugating enzyme E2 variant 1 8.3 0.6 20 Cytoplasmic aconitate hydratase 6.8 0.5 2 Ubiquitin-like modifier-activating enzyme 1 7.7 0.7 18 2-deoxynucleoside 5-phosphate N-hydrolase 1 6.8 0.4 2 Ubiquitin-like modifier-activating enzyme ATG7 7.3 0.5 6 Oligodendrocyte-myelin glycoprotein 6.8 0.1 2 Ubiquitin-like-conjugating enzyme ATG3 7.6 0.5 8 Ig kappa chain V-I region Scw 6.7 0.2 2 UDP-glucose:glycoprotein glucosyltransferase 1 7.5 0.6 13 Importin-9 6.7 0.4 2 UMP-CMP kinase 6.7 0.5 4 ATP synthase subunit f, mitochondrial 6.7 1.1 2 Uncharacterized protein C9orf142 7.5 0.5 15 Tropomodulin-1 6.7 0.2 2 Uncharacterized protein KIAA1328 8.5 0.5 20 RuvB-like 2 6.7 0.4 2 Unconventional myosin-Ie/f 7.6 0.7 11 26S protease regulatory subunit 4 6.6 0.0 2 Unconventional myosin-XVIIIa 7.2 0.3 4 Microtubule-associated protein tau 6.6 0.2 2 UPF0556 protein C19orf10 6.6 0.3 9 Ficolin-2 6.6 0.4 2 UPF0687 protein C20orf27 7.5 0.3 9 Major prion protein 6.6 0.1 2 Uroporphyrinogen decarboxylase 7.2 0.3 10 Blood group Rh(D/C/E) polypeptide 6.5 0.3 2 UTP--glucose-1-phosphate uridylyltransferase 8.0 0.9 19 40S ribosomal protein S20 6.5 0.2 2 UV excision repair protein RAD23 homolog B 7.5 0.6 18 PEST proteolytic signal-containing nuclear protein 6.5 0.2 2 Vacuolar protein sorting-associated protein 26A 7.4 0.4 8 Matrix-remodeling-associated protein 5 6.5 0.0 2 Vacuolar protein sorting-associated protein 35 7.2 0.4 8 Neuromodulin 6.4 0.4 2 Valine--tRNA ligase 6.5 0.4 9 Dickkopf-related protein 3 6.3 0.0 2 Vascular non-inflammatory molecule 2 7.8 0.3 14 Macrophage colony-stimulating factor 1 receptor 6.3 0.0 2 Vasodilator-stimulated phosphoprotein 8.9 0.6 20 Neurofilament heavy polypeptide 6.2 0.2 2 Vasorin 6.8 0.6 7 Ig superfamily containing leucine-rich repeat protein 6.1 0.6 2 Versican core protein 7.6 0.7 20 26S protease regulatory subunit 6B 6.0 0.3 2 Vesicle transport through interaction with t-SNAREs homolog 1B 7.6 0.6 17 Hematological and neurological expressed 1 protein 6.0 0.4 2 Vesicle-associated membrane protein 2/3 7.3 1 Minor histocompatibility protein HA-1 5.9 0.3 2 Vesicle-associated membrane protein-associated protein A/B/C 6.8 0.6 15 Electron transfer flavoprotein subunit alpha, mitochondrial 5.9 0.0 2 Vesicle-fusing ATPase 7.2 0.3 9 ATP-binding cassette sub-family F member 1 5.8 0.2 2 Vesicular integral-membrane protein VIP36 7.9 1 Calmodulin-like protein 3 8.5 1 Vimentin 9.8 0.4 20 Carcinoembryonic antigen-related cell adhesion molecule 5 8.3 1 Vinculin 9.5 0.3 20 Fibulin-1 8.3 1 Visinin-like protein 1 7.0 0.6 9 Cadherin-1 8.3 1 Vitamin D-binding protein 8.3 1.1 20 Ig kappa chain V-II region TEW 8.2 1 Vitamin K-dependent protein S 7.0 1.0 14 CD109 antigen 8.2 1 Vitamin K-dependent protein Z 6.9 0.4 4 Acetyl-CoA carboxylase 1/Biotin carboxylase 8.1 1 Vitronectin 8.6 0.5 20 Phosphate carrier protein, mitochondrial 8.0 1 Voltage-dependent anion-selective channel protein 1 7.7 0.8 6 Vesicular integral-membrane protein VIP36 7.9 1 Voltage-dependent anion-selective channel protein 2 7.1 0.8 11 Tumor-associated calcium signal transducer 2 7.7 1 Voltage-dependent anion-selective channel protein 3 7.8 0.4 4

Tissue-type plasminogen activator 7.7 1 Voltage-gated potassium channel subunit b-2 7.7 0.5 19 Mucin-16 7.7 1 von Willebrand factor 7.3 0.7 10 NADH dehydrogenase [ubiquinone] 1 b subcomplex subunit 8, mitochondrial 7.7 1 V-type proton ATPase catalytic subunit A 8.0 1.0 19 COP9 signalosome complex subunit 8 7.6 1 V-type proton ATPase subunit B, brain isoform 7.1 0.4 10 Heterogeneous nuclear ribonucleoprotein U-like protein 2 7.6 1 V-type proton ATPase subunit C 1 7.2 0.5 10 Dynein heavy chain 5, axonemal 7.6 1 V-type proton ATPase subunit D 6.9 0.5 3 Coagulation factor X 7.6 1 V-type proton ATPase subunit E 1 7.4 0.5 13 Anterior gradient protein 2 homolog 7.6 1 V-type proton ATPase subunit G 1 7.6 0.6 14 Dermcidin 7.6 1 V-type proton ATPase subunit G 2 6.3 0.3 3 Complement factor D 7.5 1 WAP four-disulfide core domain protein 3 8.4 0.5 20 Thymosin beta-10 7.5 1 WD repeat-containing protein 1 7.9 0.9 17 Ras-related protein Rab-3D 7.5 1 WD repeat-containing protein 37 7.3 0.3 7 NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial 7.5 1 Wiskott-Aldrich syndrome protein 6.3 0.8 5 Insulin-like growth factor-binding protein 7 7.4 1 Wiskott-Aldrich syndrome protein family member 2 7.0 0.4 4 40S ribosomal protein S13 7.4 1 WW domain-binding protein 2 7.2 0.3 16 Beta-mannosidase 7.4 1 Xaa-Pro dipeptidase 7.5 0.4 19 Ras-related protein Rab-31 7.4 1 X-ray repair cross-complementing protein 5 7.3 0.9 10 AP-2 complex subunit m 7.4 1 X-ray repair cross-complementing protein 6 7.6 0.7 12 Mucin-1 7.4 1 Zinc-alpha-2-glycoprotein 9.5 0.5 20 NADH dehydrogenase [ubiquinone] 1 b subcomplex subunit 6 7.4 1 Zyxin 7.1 0.6 20 Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A b isoform 7.4 1 1,4-alpha-glucan-branching enzyme 7.4 0.8 17 Neutral amino acid transporter B(0) 7.4 1 10 kDa heat shock protein, mitochondrial 7.5 0.7 18 Vesicle-associated membrane protein 2/3 7.3 1 14-3-3 protein a/b 8.4 0.7 20 Ras-related protein Rab-43 7.3 1 14-3-3 protein epsilon 8.8 0.4 20 Peptidase inhibitor 16 7.3 1 14-3-3 protein eta 7.8 0.6 15 Coagulation factor V 7.2 1 14-3-3 protein gamma 7.8 0.4 17 Methylosome subunit pICln 7.2 1 14-3-3 protein sigma 7.0 0.7 7 Nuclease-sensitive element-binding protein 1 7.2 1 14-3-3 protein theta 7.5 0.6 16 Radixin 7.2 1 14-3-3 protein z/d 9.4 0.5 20 Kinesin heavy chain isoform 5C 7.1 1 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase b-2 7.0 0.8 16 Kallikrein-6 7.1 1 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase g-2 7.0 0.5 8 Ubiquitin thioesterase OTU1 7.1 1 2,3-cyclic-nucleotide 3-phosphodiesterase 8.1 0.8 17 60S ribosomal protein L29 7.0 1 26S protease regulatory subunit 10B 7.8 0.4 8 Procollagen C-endopeptidase enhancer 1 7.0 1 26S protease regulatory subunit 4 6.6 0.0 2 72 kDa type IV collagenase 7.0 1 26S protease regulatory subunit 6A 6.8 0.2 8 Ig kappa chain V-II region MIL 6.9 1 26S protease regulatory subunit 6B 6.0 0.3 2

4-trimethylaminobutyraldehyde dehydrogenase 6.9 1 26S protease regulatory subunit 7 7.2 0.5 3 Multiple inositol polyphosphate phosphatase 1 6.8 1 26S proteasome non-ATPase regulatory subunit 1 7.2 0.4 9 Dipeptidyl aminopeptidase-like protein 6 6.8 1 26S proteasome non-ATPase regulatory subunit 11 6.6 0.6 4 Charged multivesicular body protein 4a 6.8 1 26S proteasome non-ATPase regulatory subunit 2 7.1 0.6 16 Hydroxypyruvate isomerase 6.8 1 26S proteasome non-ATPase regulatory subunit 5 7.0 0.3 3 26S proteasome non-ATPase regulatory subunit 8 6.8 1 26S proteasome non-ATPase regulatory subunit 6 7.2 0.5 9 Glutaminase kidney isoform, mitochondrial 6.8 1 26S proteasome non-ATPase regulatory subunit 8 6.8 1 Structural maintenance of chromosomes protein 3 6.8 1 26S proteasome non-ATPase regulatory subunit 9 6.6 0.5 8 ICOS ligand 6.7 1 2-deoxynucleoside 5-phosphate N-hydrolase 1 6.8 0.4 2 Golgi membrane protein 1 6.7 1 3-Ketoacyl-CoA thiolase 7.6 0.5 4 Long-chain-fatty-acid--CoA ligase 1/5 6.7 1 3-ketoacyl-CoA thiolase, mitochondrial 6.8 0.4 7 Torsin-4A 6.7 1 3-mercaptopyruvate sulfurtransferase 7.6 0.6 17 Target of Nesh-SH3 6.6 1 40S ribosomal protein S13 7.4 1 Erythroid membrane-associated protein 6.6 1 40S ribosomal protein S20 6.5 0.2 2 Cullin-4A 6.6 1 40S ribosomal protein SA 6.9 0.3 7 Ran-binding protein 6 6.5 1 4F2 cell-surface antigen heavy chain 6.7 0.6 7 Pre-mRNA-processing-splicing factor 8 6.5 1 4-trimethylaminobutyraldehyde dehydrogenase 6.9 1 Heterogeneous nuclear ribonucleoprotein H3 6.4 1 55 kDa erythrocyte membrane protein 7.6 0.6 11 Heat shock protein 105 kDa 6.4 1 5-nucleotidase domain-containing protein 1 7.2 0.3 5 SPARC-like protein 1 6.4 1 60 kDa heat shock protein, mitochondrial 6.7 0.8 11 Collagen alpha-1(XVIII) chain 6.4 1 60 kDa SS-A/Ro ribonucleoprotein 7.6 0.5 18 Transcription elongation factor A protein-like 5 6.3 1 60S acidic ribosomal protein P0 6.0 1.0 13 Glycophorin-A 6.3 1 60S acidic ribosomal protein P1 7.5 0.6 15 Laminin subunit b-3 6.2 1 60S acidic ribosomal protein P2 7.6 0.6 16 60S ribosomal protein L4 6.2 1 60S ribosomal protein L29 7.0 1 Scavenger receptor cysteine-rich type 1 protein M130/Soluble CD163 6.2 1 60S ribosomal protein L4 6.2 1 NADP-dependent malic enzyme 6.2 1 6-phosphogluconate dehydrogenase 9.3 0.5 20 Myosin light chain 4 5.8 1 6-phosphogluconolactonase 8.0 0.4 19 Cadherin-13 5.8 1 7,8-dihydro-8-oxoguanine triphosphatase 6.1 0.2 4 E3 ubiquitin-protein ligase UBR4 5.4 1 72 kDa type IV collagenase 7.0 1 Ubiquilin-2 5.2 1 78 kDa glucose-regulated protein 8.8 0.6 20

Supplemental Table 2: Protein levels, as detected by MS, that correlate with brain abscess volume. The levels of 288 proteins, as detected by MS, that were present in the extracellular (supernatant) fluid of 20 brain abscess pus samples were correlated with the volumes of the brain abscesses as measured on MRIs, using Spearman's test (GraphPad Prism). The level of the 57 proteins given below correlated with abscess volume. The table gives the proteins, their origin (serum, neutrophils, or non-specific origin), the correlation coefficient, the 95% confidence interval, and the 2-tailed p value. a) CAM: cell adhesion molecule.

Protein Origin Spearman r 95% CI P value Ig λ chain V-III region SH Serum 0.78 0.50 - 0.91 < 0.0001 α-2-Macroglobulin Serum 0.71 0.37 - 0.88 0.0005 α-1B-Glycoprotein Serum 0.70 0.37 - 0.88 0.0005 Aminopeptidase N Non-specific 0.70 0.36 - 0.88 0.0006 α-1-Acid glycoprotein 1 Serum 0.69 0.35 - 0.87 0.0008 Corticosteroid-binding globulin Serum 0.67 0.31 - 0.86 0.001 Myeloperoxidase Neutrophils 0.64 0.26 - 0.85 0.002 Ceruloplasmin Serum 0.63 0.24 - 0.84 0.003 α-1-Acid glycoprotein 2 Serum 0.63 0.24 - 0.84 0.003 ß-Glucuronidase Non-specific 0.62 0.23 - 0.84 0.004 Azurocidin Neutrophils 0.61 0.21 - 0.83 0.005 Complement C4-B Serum 0.60 0.19 - 0.83 0.006 Plasma protease C1 inhibitor Serum 0.59 0.19 - 0.82 0.006 a Carcinoembryonic antigen-related CAM 6 Non-specific 0.58 0.17 - 0.82 0.008 Lactotransferrin Neutrophils 0.57 0.16 - 0.81 0.008 α-1-Antitrypsin Serum 0.57 0.15 - 0.81 0.009 Zinc-α-2-glycoprotein Serum 0.56 0.14 - 0.81 0.010 Histone H4 Non-specific 0.56 0.14 - 0.81 0.011 Maltase-glucoamylase, intestinal Non-specific 0.56 0.14 - 0.81 0.011 Ig κ chain V-I region EU Serum 0.55 0.13 - 0.81 0.011 C4b-binding protein α chain Serum 0.54 0.12 - 0.80 0.014

Phospholipase B-like 1 Non-specific 0.54 0.11 - 0.80 0.014 Superoxide dismutase [Mn], mitochondrial Neutrophils 0.54 0.11 - 0.80 0.014 Glutathione reductase, mitochondrial Non-specific 0.54 0.11 - 0.80 0.014 Ig κ chain V-I region Ni Serum 0.53 0.10 - 0.79 0.016 Antithrombin-III Serum 0.53 0.10 - 0.79 0.016 Serum amyloid P-component Serum 0.53 0.10 - 0.79 0.016 Cathelicidin antimicrobial peptide LL-37 Neutrophils 0.52 0.09 - 0.79 0.018 Protein S100-A11 Neutrophils 0.52 0.09 - 0.79 0.018 Glutathione peroxidase 3 Neutrophils 0.52 0.09 - 0.79 0.019 Complement C3 Serum 0.52 0.08 - 0.79 0.020 Complement factor B Serum 0.52 0.08 - 0.79 0.020 Ig κ chain V-III region CLL Serum 0.51 0.08 - 0.78 0.021 Resistin Neutrophils 0.51 0.07 - 0.78 0.022 Proteasome subunit βtype Non-specific 0.51 0.070 - 0.78 0.022 Serotransferrin Serum 0.51 0.07 - 0.78 0.023 Uncharacterized protein KIAA1328 Non-specific 0.50 0.06 - 0.78 0.024 Plasma kallikrein Serum 0.50 0.06 - 0.78 0.025 WAP four-disulfide core domain protein 3 Non-specific 0.49 0.05 - 0.78 0.027 Proteasome subunit βtype-7 Non-specific 0.49 0.05 - 0.77 0.027 Nucleophosmin Non-specific 0.49 0.05 - 0.77 0.028 Ig κ chain V-I region WEA Serum 0.49 0.05 - 0.77 0.028 Leucine-rich α-2-glycoprotein Serum 0.49 0.04 - 0.77 0.029 Ig α-1 chain C region Serum 0.48 0.04 - 0.77 0.031 Proteasome subunit ßtype-3 Non-specific 0.47 0.02 - 0.76 0.036 Neutrophil collagenase Neutrophils 0.47 0.02 - 0.76 0.037 Apolipoprotein D Serum 0.47 0.02 - 0.76 0.037 Ig λ chain V-II region NIG-84 Serum 0.47 0.02 - 0.76 0.037 Ig λ-1 chain C regions Serum 0.46 0.006 - 0.76 0.042 Cathepsin G Neutrophils 0.46 0.004 - 0.75 0.043 Ig µ chain C region Serum 0.46 0.004 - 0.75 0.043

Serum albumin Serum 0.46 0.002 - 0.75 0.044 Ig γ-2 chain C region Serum 0.45 -0.006 - 0.75 0.047 Translin Non-specific 0.45 -0.006 - 0.75 0.047 Proteasome subunit α type-7 Non-specific 0.45 -0.007 - 0.75 0.047 Proteasome subunit αtype-4 Non-specific 0.45 -0.008 - 0.75 0.048 Proteasome subunit ßtype-1 Non-specific 0.44 -0.011 - 0.75 0.049

Supplemental Table 3: 436 proteins in cell-rich (not centrifuged) brain abscess pus that were not found in pus extracellular fluid, arranged according to abundance and alphabetically. Proteins from uncentrifuged pus from 20 brain abscesses were analyzed by mass spectrometry. Data are log -10 transformations of raw data from the mass spectrometry analysis (mean and SD values). Values are calculated from the samples in which a protein was detected; the number of positive samples are given in the columns "N". To the left proteins are listed according to their abundance; to the right they are listed alphabetically.

Abundance Alphabetically

Mea S Mea Protein n D N Protein n SD N

2 Protein FAM3C 11.0 0.1 0 Abl interactor 1 7.4 0.0 2 2 Microtubule-associated protein 1A 10.1 0.3 0 Acyl-CoA:lysophosphatidylglycerol acyltransferase 1 7.7 0.5 17 2 Ig epsilon chain C region 9.6 0.4 0 Acyl-protein thioesterase 2 6.7 0.1 3 2 Unconventional myosin-Va 9.5 0.4 0 Adapter molecule crk 7.6 0.2 7 2 Ankyrin-2 9.4 0.3 0 ADP/ATP translocase 1 6.9 0.4 9 2 Guanylate kinase 9.4 0.5 0 ADP/ATP translocase 3 6.9 1 2 Calcyphosin 9.1 0.3 0 ADP-dependent glucokinase 7.9 0.4 20 2 Disks large homolog 4 9.0 0.4 0 ADP-ribosylation factor 4 6.5 0.3 5 2 Microtubule-associated protein 2 8.9 0.4 0 ADP-ribosylation factor 5 7.0 0.5 9 2 Coatomer subunit delta 8.8 0.3 0 Alanine--tRNA ligase, cytoplasmic 7.2 0.2 3 2 Matrin-3 8.7 0.4 0 Amphiphysin 6.9 0.4 2 2 Heat shock 70 kDa protein 12A 8.7 0.4 0 Ankyrin-2 9.4 0.3 20 2 Eukaryotic translation initiation factor 2 subunit 3 8.6 0.3 0 AP-1 complex subunit sigma-2 6.8 0.2 3 2 Succinyl-CoA:3-ketoacid coenzyme A transferase 1, mitochondrial 8.4 0.5 0 AP-3 complex subunit delta-1 8.6 1.4 18 2 Glycogen phosphorylase, brain form 8.4 0.4 0 Apolipoprotein L2 7.7 0.5 3 2 Microtubule-associated protein 6 8.4 0.4 0 Apoptosis regulator BAX 7.5 0.5 16 2 Transgelin-3 8.4 0.6 0 Apoptotic protease-activating factor 1 7.5 0.3 12 2 Calponin-3 8.4 0.5 0 Arachidonate 5-lipoxygenase-activating protein 7.8 0.4 3 2 Ras-related protein Rab-3C 8.3 0.4 0 Arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 1 7.0 0.3 16 2 WAS/WASL-interacting protein family member 1 8.3 0.4 0 Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 7.8 0.3 20 2 Leukocyte-specific transcript 1 protein 8.3 0.3 0 Arginine--tRNA ligase, cytoplasmic 7.1 0.2 7 2 Neural cell adhesion molecule L1 8.2 0.5 0 Aspartate carbamoyltransferase 6.7 0.2 3 2 Splicing factor U2AF 35 kDa subunit 8.1 0.3 0 Aspartate--tRNA ligase, cytoplasmic 7.6 1 2 NADH dehydrogenase iron-sulfur protein 8, mitochondrial 8.1 0.5 0 Astrocytic phosphoprotein PEA-15 7.6 1 2 Interferon-induced GTP-binding protein Mx1 8.1 0.7 0 Atlastin-1 6.3 1 2 Serine/threonine-protein kinase 10 7.9 0.4 0 ATP-dependent 6-phosphofructokinase, muscle type 7.0 1 2 Ectonucleotide pyrophosphatase/phosphodiesterase family member 6 7.9 0.3 0 ATP-dependent 6-phosphofructokinase, platelet type 7.2 0.2 2 2 ADP-dependent glucokinase 7.9 0.4 0 ATP-dependent RNA helicase A 6.8 0.3 13 2 Endoplasmic reticulum resident protein 44 7.9 0.4 0 B-cell receptor-associated protein 31 7.4 1 2 Transcription factor PU.1 7.8 0.9 0 Bcl-2-like protein 15 7.5 0.9 5 2 V-set and immunoglobulin domain-containing protein 4 7.8 0.4 0 Beta-adrenergic receptor kinase 1 7.3 0.2 3 2 Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 7.8 0.3 0 Beta-synuclein 6.6 0.7 13 2 Protein flightless-1 homolog 7.7 0.5 0 Bifunctional glutamate/proline--tRNA ligase 6.8 0.1 4 2 Tropomyosin alpha-4 chain 7.7 0.4 0 Bis(5-adenosyl)-triphosphatase ENPP4 7.5 0.0 3 Protein kinase C delta type 7.6 0.5 2 BRI3-binding protein 7.1 0.3 9 0 2 Noelin 7.6 0.4 0 C5a anaphylatoxin chemotactic receptor 1 6.8 0.3 4 2 Paraspeckle component 1 7.6 0.4 0 Calcium/calmodulin-dependent protein kinase type II subunit beta 6.9 1 2 Liprin-alpha-2 7.4 0.4 0 Calcium/calmodulin-dependent protein kinase type II subunit delta 7.4 0.1 3 2 Probable ubiquitin carboxyl-terminal hydrolase FAF-X 7.4 0.4 0 Calcium-binding mitochondrial carrier protein Aralar1 7.0 0.3 4 2 Formin-like protein 2 7.2 0.3 0 Calcium-binding mitochondrial carrier protein SCaMC-1 6.7 0.4 12 2 Putative RNA-binding protein Luc7-like 2 7.1 0.4 0 Calcyphosin 9.1 0.3 20 1 Protein FAM63A 8.5 0.5 9 Calponin-3 8.4 0.5 20 1 TAR DNA-binding protein 43 8.5 0.6 9 Calumenin 6.3 1 1 Golgin subfamily A member 2 8.4 0.4 9 CaM kinase-like vesicle-associated protein 7.3 0.4 10 1 Persulfide dioxygenase ETHE1, mitochondrial 8.2 0.5 9 cAMP-dependent protein kinase type II-beta regulatory subunit 7.0 0.2 3 1 Translocon-associated protein subunit alpha 8.2 0.5 9 CAP-Gly domain-containing linker protein 1 6.5 1 1 Osteoclast-associated immunoglobulin-like receptor 8.2 0.3 9 CAP-Gly domain-containing linker protein 2 6.5 0.3 7 1 Signal transducer and activator of transcription 3 7.9 0.7 9 Cathepsin Z 7.4 1 1 Dynein light chain roadblock-type 1/2 7.8 0.6 9 CDGSH iron-sulfur domain-containing protein 1 6.9 1 1 Polymeric immunoglobulin receptor 7.8 0.4 9 CDK5 regulatory subunit-associated protein 3 7.4 1 1 Protein THEMIS2 7.8 0.3 9 Cell adhesion molecule 3 6.4 0.6 2 1 Ketimine reductase mu-crystallin 7.6 0.4 9 C-Jun-amino-terminal kinase-interacting protein 3/4 7.0 1 1 Putative sodium-coupled neutral amino acid transporter 10 7.6 0.4 9 Clathrin coat assembly protein AP180 7.4 0.7 19 1 Clathrin coat assembly protein AP180 7.4 0.7 9 Clathrin light chain A 7.2 1 1 AP-3 complex subunit delta-1 8.6 1.4 8 Clathrin light chain B 7.0 0.5 3 1 Microsomal glutathione S-transferase 2 8.1 0.3 8 Claudin-11 8.7 0.5 5 1 Protein ERGIC-53 7.9 0.5 8 Coatomer subunit alpha 6.8 0.3 9 1 Ras-related protein Rab-3A 7.8 0.5 8 Coatomer subunit delta 8.8 0.3 20 1 Translocon-associated protein subunit delta 7.7 0.4 8 Coiled-coil domain-containing protein 88B 6.5 1 1 Protein NDRG1 7.3 0.4 8 Coiled-coil domain-containing protein 93 6.8 0.3 3 1 Secretogranin-2/Secretoneurin 7.1 0.3 8 Complexin-2 6.8 0.7 4 1 Hepatocyte growth factor activator 6.9 0.4 8 COP9 signalosome complex subunit 6 6.9 0.1 2 1 Leukotriene-B(4) omega-hydroxylase 1/2 7.9 0.3 7 Copine-1 6.9 0.2 10 1 Acyl-CoA:lysophosphatidylglycerol acyltransferase 1 7.7 0.5 7 Coronin-7 7.6 0.5 10 1 Starch-binding domain-containing protein 1 7.6 0.3 7 Creatine kinase M-type 7.6 0.4 9 1 Fatty acid-binding protein, brain 7.6 0.3 7 Creatine kinase U-type, mitochondrial 7.2 0.2 4 1 Endophilin-B2 7.6 0.4 7 Cysteine and glycine-rich protein 1 7.1 1 1 Serine beta-lactamase-like protein LACTB, mitochondrial 7.3 0.6 7 Cytochrome c oxidase subunit 2 7.5 0.3 13 1 Programmed cell death protein 10 7.2 0.4 7 Cytochrome c oxidase subunit 5B, mitochondrial 7.4 0.3 3 1 Rap1 GTPase-GDP dissociation stimulator 1 6.6 0.4 7 Cytoplasmic dynein 1 intermediate chain 2 7.2 0.1 2 1 Putative pre-mRNA-splicing factor ATP-dependent RNA helicase DHX15 7.9 0.4 6 DAZ-associated protein 1 7.2 0.3 15 1 Probable ATP-dependent RNA helicase DDX17 7.7 0.4 6 Dedicator of cytokinesis protein 2 6.7 0.3 4 1 Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7 7.5 0.5 6 Dematin 7.0 0.1 2 1 Serine/arginine-rich splicing factor 7 7.5 0.5 6 Density-regulated protein 7.0 1 1 F-box only protein 2 7.5 0.5 6 Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 7.2 1 1 Apoptosis regulator BAX 7.5 0.5 6 Diacylglycerol kinase alpha 8.1 1 1 Heterogeneous nuclear ribonucleoprotein R 7.4 0.3 6 Differentially expressed in FDCP 6 homolog 7.5 1

Microtubule-associated protein 1S 7.2 0.2 1 Dihydrofolate reductase 6.8 0.4 11 6 1 Double-stranded RNA-binding protein Staufen homolog 1 7.2 0.4 6 Dihydropyrimidinase-related protein 3 7.2 0.2 7 1 Arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 1 7.0 0.3 6 Disks large homolog 4 9.0 0.4 20 1 Spliceosome RNA helicase DDX39B;ATP-dependent RNA helicase DDX39A 7.0 0.7 6 DNA repair protein RAD50 7.4 0.3 10 1 Septin-11 7.9 0.6 5 DNA-dependent protein kinase catalytic subunit 7.3 0.4 9 1 Flap endonuclease 1 7.5 0.5 5 DnaJ homolog subfamily B member 2 7.0 0.3 9 1 Tyrosine-protein kinase Fgr 7.4 0.6 5 DnaJ homolog subfamily C member 18 6.5 1 1 Metallo-beta-lactamase domain-containing protein 2 7.4 0.8 5 DnaJ homolog subfamily C member 5 6.0 1 1 Phenylalanine--tRNA ligase beta subunit 7.4 0.6 5 DnaJ homolog subfamily C member 8 6.4 1 1 Replication protein A 14 kDa subunit 7.3 0.4 5 DnaJ homolog subfamily C member 9 7.0 0.2 7 1 DAZ-associated protein 1 7.2 0.3 5 Docking protein 3 7.5 0.2 5 1 Phosphoserine aminotransferase 6.9 0.6 5 Double-stranded RNA-binding protein Staufen homolog 1 7.2 0.4 16 1 Gamma-adducin 7.8 0.5 4 Dynamin-1 6.7 0.4 6 1 60S ribosomal protein L6 7.5 0.3 4 Dynamin-1-like protein 7.2 0.4 12 1 Proline-rich transmembrane protein 2 7.4 0.2 4 Dynamin-3 7.0 1 1 RuvB-like 1 7.2 0.4 4 Dynamin-like 120 kDa protein, mitochondrial 7.4 1 1 Structural maintenance of chromosome flexible hinge domain-containing 1 6.9 0.4 4 Dynein light chain roadblock-type 1/2 7.8 0.6 19 1 Glyoxylate reductase/hydroxypyruvate reductase 6.8 0.2 4 Dystonin 6.5 1 1 Tyrosine-protein kinase Lyn 7.6 0.4 3 E3 ubiquitin-protein ligase MYCBP2 6.4 1 1 Cytochrome c oxidase subunit 2 7.5 0.3 3 E3 ubiquitin-protein ligase TRIM21 6.9 1 1 Vacuolar protein sorting-associated protein 29 7.2 0.6 3 Early endosome antigen 1 7.1 0.0 2 1 Stromal interaction molecule 1 7.2 0.4 3 Ectonucleotide pyrophosphatase/phosphodiesterase family member 6 7.9 0.3 20 1 Heterogeneous nuclear ribonucleoprotein M 7.0 0.3 3 EH domain-containing protein 3 7.3 1 1 Putative heat shock protein HSP 90-beta 4 6.8 0.3 3 Elongation factor 1-alpha 1 7.2 1 1 ATP-dependent RNA helicase A 6.8 0.3 3 Endophilin-A1 7.0 1 1 Rab3 GTPase-activating protein non-catalytic subunit 6.7 0.2 3 Endophilin-B2 7.6 0.4 17 1 Beta-synuclein 6.6 0.7 3 Endoplasmic reticulum resident protein 44 7.9 0.4 20 1 UPF0568 protein C14orf166 8.0 0.8 2 Estradiol 17-beta-dehydrogenase 11 6.9 0.1 2 1 Sodium/potassium-transporting ATPase subunit a-2 7.6 0.6 2 Estradiol 17-beta-dehydrogenase 12 7.2 0.7 12 1 Apoptotic protease-activating factor 1 7.5 0.3 2 Eukaryotic translation elongation factor 1 epsilon-1 6.5 1 1 GRIP1-associated protein 1 7.4 0.2 2 Eukaryotic translation initiation factor 2 subunit 3 8.6 0.3 20 1 Intercellular adhesion molecule 2 7.3 0.6 2 Eukaryotic translation initiation factor 3 subunit E 6.9 0.2 4 1 Dynamin-1-like protein 7.2 0.4 2 Eukaryotic translation initiation factor 3 subunit I 6.9 0.1 2 1 Signal transducer and activator of transcription 1-alpha/beta 7.2 0.3 2 Eukaryotic translation initiation factor 3 subunit M 6.7 0.2 3 1 Septin-4 7.2 0.3 2 Eukaryotic translation initiation factor 4 gamma 2 7.0 1 1 Estradiol 17-beta-dehydrogenase 12 7.2 0.7 2 Excitatory amino acid transporter 1 7.5 1 1 Tubulin polymerization-promoting protein family member 3 7.1 0.4 2 Excitatory amino acid transporter 2 8.8 1.1 6 1 Synaptogyrin-1 7.0 0.5 2 Extended synaptotagmin-1 6.6 0.2 4 1 Probable G-protein coupled receptor 97 6.9 0.4 2 Extended synaptotagmin-2 7.4 1 1 Neutrophil defensin 1/2/3 6.9 0.3 2 Far upstream element-binding protein 2 7.4 0.4 3 1 Folate receptor gamma 6.8 0.2 2 Fatty acid-binding protein, brain 7.6 0.3 17 1 Calcium-binding mitochondrial carrier protein SCaMC-1 6.7 0.4 2 F-box only protein 2 7.5 0.5 16 1 ProSAAS/KEP/Big SAAS/Little SAAS/Big PEN-LEN/PEN/Little LEN/Big LEN 7.6 0.4 1 Ficolin-1 6.9 1

Neuronal membrane glycoprotein M6-a 7.3 0.6 1 FK506-binding protein 15 7.0 1

1 1 Ras-related protein Rab-6A/6B 7.2 0.2 1 Flap endonuclease 1 7.5 0.5 15 1 Tropomyosin beta chain 7.1 0.4 1 Folate receptor gamma 6.8 0.2 12 1 Protein transport protein Sec24C 7.0 0.3 1 Formin-like protein 2 7.2 0.3 20 1 Dihydrofolate reductase 6.8 0.4 1 G protein-coupled receptor kinase 6 6.9 0.2 2 1 Neurochondrin 6.2 0.2 1 Galactokinase 7.9 0.2 5 1 Coronin-7 7.6 0.5 0 Gamma-adducin 7.8 0.5 14 1 DNA repair protein RAD50 7.4 0.3 0 Gamma-parvin 7.3 1 1 Vesicle-associated membrane protein 7 7.4 0.3 0 Gamma-soluble NSF attachment protein 6.5 1 1 Glycine--tRNA ligase 7.4 0.6 0 Ganglioside-induced differentiation-associated protein 1 7.0 0.0 2 1 CaM kinase-like vesicle-associated protein 7.3 0.4 0 Gasdermin-D 6.4 0.3 3 1 Leucine--tRNA ligase, cytoplasmic 7.2 0.2 0 General vesicular transport factor p115 6.8 1 1 Myosin-14 7.2 0.3 0 Gephyrin 7.3 0.3 2 1 Ras-related protein Rab-44 7.1 0.3 0 Glycine--tRNA ligase 7.4 0.6 10 1 3-hydroxyacyl-CoA dehydrogenase type-2 7.1 0.3 0 Glycogen phosphorylase, brain form 8.4 0.4 20 1 Copine-1 6.9 0.2 0 Glyoxylate reductase/hydroxypyruvate reductase 6.8 0.2 14 Hippocalcin-like protein 4 8.1 0.8 9 Golgin subfamily A member 2 8.4 0.4 19 Proline synthase co-transcribed bacterial homolog protein 7.7 0.8 9 GRIP1-associated protein 1 7.4 0.2 12 Creatine kinase M-type 7.6 0.4 9 GTP-binding protein SAR1a 7.3 1

DNA-dependent protein kinase catalytic subunit 7.3 0.4 9 Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7 7.5 0.5 16 BRI3-binding protein 7.1 0.3 9 Guanine nucleotide-binding protein G(s) subunit alpha isoforms Xlas 6.9 0.2 4 DnaJ homolog subfamily B member 2 7.0 0.3 9 Guanine nucleotide-binding protein subunit alpha-13 6.3 0.2 2 ADP-ribosylation factor 5 7.0 0.5 9 Guanylate kinase 9.4 0.5 20 ADP/ATP translocase 1 6.9 0.4 9 HD domain-containing protein 2 7.7 1

Coatomer subunit alpha 6.8 0.3 9 Heat shock 70 kDa protein 12A 8.7 0.4 20 Rab11 family-interacting protein 1 6.7 0.5 9 Heat shock-related 70 kDa protein 2 7.0 0.0 2 Ras-related protein Rap-2a 7.3 0.4 8 Hepatocyte growth factor activator 6.9 0.4 18 Pleckstrin homology domain-containing family O member 2 7.3 0.5 8 Heterogeneous nuclear ribonucleoprotein M 7.0 0.3 13 Microtubule-actin cross-linking factor 1, isoforms 1/2/3/5 7.3 0.3 8 Heterogeneous nuclear ribonucleoprotein R 7.4 0.3 16 Tubulin alpha chain-like 3 7.3 0.2 8 High mobility group protein B3 6.7 1

Synapsin-2 7.2 0.4 8 Hippocalcin-like protein 4 8.1 0.8 9 Ubiquitin-conjugating enzyme E2 H 6.8 0.3 8 Histone-binding protein RBBP4/7 7.5 0.4 6 60S ribosomal protein L7a 7.6 0.5 7 HLA class I histocompatibility antigen, A1/A3/A-11/A36 alpha chain 7.2 0.2 6 Adapter molecule crk 7.6 0.2 7 HLA class I histocompatibility antigen, A-68 alpha chain 7.0 0.1 3 Signal recognition particle receptor subunit beta 7.5 0.8 7 Homer protein homolog 1 7.4 1

Peptidyl-prolyl cis-trans isomerase FKBP2 7.2 0.8 7 Ig alpha Fc receptor 7.6 0.2 2 TIP41-like protein 7.2 0.3 7 Ig epsilon chain C region 9.6 0.4 20 Dihydropyrimidinase-related protein 3 7.2 0.2 7 Ig lambda-like polypeptide 5 6.7 0.5 5 Arginine--tRNA ligase, cytoplasmic 7.1 0.2 7 Ig superfamily member 8 6.9 0.3 3 40S ribosomal protein S7 7.0 0.4 7 Inosine-5-monophosphate dehydrogenase 2 7.3 0.2 6 DnaJ homolog subfamily C member 9 7.0 0.2 7 Integrin alpha-6 6.9 0.3 5 Katanin p60 ATPase-containing subunit A-like 2 7.0 0.4 7 Integrin-linked protein kinase 8.0 0.7 6 Serine/threonine-protein kinase PAK 2/3 6.9 0.2 7 Intercellular adhesion molecule 2 7.3 0.6 12 Nucleosome assembly protein 1-like 1 6.7 0.6 7 Intercellular adhesion molecule 3 6.6 1

2-oxoglutarate dehydrogenase, mitochondrial 6.6 0.2 7 Interferon-induced GTP-binding protein Mx1 8.1 0.7 20 Poliovirus receptor 6.6 0.3 7 Katanin p60 ATPase-containing subunit A-like 2 7.0 0.4 7 CAP-Gly domain-containing linker protein 2 6.5 0.3 7 Ketimine reductase mu-crystallin 7.6 0.4 19 Excitatory amino acid transporter 2 8.8 1.1 6 Kinesin light chain 1 7.0 0.4 4 Integrin-linked protein kinase 8.0 0.7 6 Kinesin-like protein KIF2A 6.5 0.6 2 Transmembrane protein 43 7.7 0.3 6 Lactoylglutathione lyase 7.3 0.4 6 Histone-binding protein RBBP4/7 7.5 0.4 6 LETM1 and EF-hand domain-containing protein 1, mitochondrial 6.3 1

Small nuclear ribonucleoprotein Sm D3 7.3 0.1 6 Leucine--tRNA ligase, cytoplasmic 7.2 0.2 10 Inosine-5-monophosphate dehydrogenase 2 7.3 0.2 6 Leukocyte-specific transcript 1 protein 8.3 0.3 20 Lactoylglutathione lyase 7.3 0.4 6 Leukotriene B4 receptor 1 6.7 1

HLA class I histocompatibility antigen, A1/A3/A-11/A36 alpha chain 7.2 0.2 6 Leukotriene-B(4) omega-hydroxylase 1/2 7.9 0.3 17 Tubulin alpha-4A chain 7.2 0.1 6 Limbic system-associated membrane protein 7.6 1

Neurogranin 7.0 0.2 6 Liprin-alpha-2 7.4 0.4 20 Mitochondrial import receptor subunit TOM70 6.9 0.7 6 L-selectin 6.9 0.0 3 Ryanodine receptor 2 6.8 0.3 6 Lymphoid-restricted membrane protein 7.3 1

Renin receptor 6.8 0.5 6 Lysophosphatidylcholine acyltransferase 2 7.0 0.5 5 Rootletin 6.7 0.2 6 Lysosome membrane protein 2 7.5 1

Dynamin-1 6.7 0.4 6 Mast cell-expressed membrane protein 1 7.2 0.2 3 Claudin-11 8.7 0.5 5 Matrin-3 8.7 0.4 20 Galactokinase 7.9 0.2 5 Matrix metalloproteinase-16 8.0 0.6 3 Ras-related protein Rab-32 7.8 0.4 5 Metallo-beta-lactamase domain-containing protein 2 7.4 0.8 15 Serglycin 7.7 0.5 5 Metallothionein-3 6.9 1

Docking protein 3 7.5 0.2 5 MICOS complex subunit MIC19 7.2 1

Bcl-2-like protein 15 7.5 0.9 5 Microsomal glutathione S-transferase 2 8.1 0.3 18 Synaptobrevin homolog YKT6 7.3 0.5 5 Microtubule-actin cross-linking factor 1, isoforms 1/2/3/5 7.3 0.3 8 Very long-chain specific acyl-CoA dehydrogenase, mitochondrial 7.2 0.4 5 Microtubule-associated protein 1A 10.1 0.3 20 Phosphatidylinositide phosphatase SAC1 7.1 0.2 5 Microtubule-associated protein 1S 7.2 0.2 16 Trypsin-1/2 7.1 0.2 5 Microtubule-associated protein 2 8.9 0.4 20 Lysophosphatidylcholine acyltransferase 2 7.0 0.5 5 Microtubule-associated protein 6 8.4 0.4 20 Stromal cell-derived factor 2-like protein 1 7.0 0.2 5 Microtubule-associated protein RP/EB family member 1 7.6 1

Serine/arginine-rich splicing factor 2/8 6.9 0.3 5 Microtubule-associated protein RP/EB family member 2 6.7 1

PDZ and LIM domain protein 5 6.9 0.3 5 Mitochondrial import receptor subunit TOM70 6.9 0.7 6 Integrin alpha-6 6.9 0.3 5 Mitogen-activated protein kinase 14 7.0 0.3 4 Neutral cholesterol ester hydrolase 1 6.8 0.3 5 Myelin-associated glycoprotein 7.4 0.5 3 Phosphopantetheine adenylyltransferase 6.8 0.2 5 Myelin-oligodendrocyte glycoprotein 7.1 1

Ig lambda-like polypeptide 5 6.7 0.5 5 Myoglobin 7.3 0.1 2 Transmembrane protein 109 6.6 0.2 5 Myosin light chain kinase, smooth muscle 6.5 0.3 3 ADP-ribosylation factor 4 6.5 0.3 5 Myosin-1/8/13 6.7 0.2 2 Secretogranin-3 6.2 0.3 5 Myosin-10 7.4 1

V-type proton ATPase subunit F 8.0 0.6 4 Myosin-14 7.2 0.3 10 Ragulator complex protein LAMTOR4 7.6 0.2 4 NAD(P) transhydrogenase, mitochondrial 7.1 1

Titin 7.4 0.3 4 NADH dehydrogenase 1 alpha subcomplex subunit 8 7.2 0.9 2 Neural cell adhesion molecule 2 7.4 0.3 4 NADH dehydrogenase flavoprotein 1, mitochondrial 7.6 1

Xaa-Pro aminopeptidase 1 7.4 0.1 4 NADH dehydrogenase iron-sulfur protein 4, mitochondrial 7.1 1

UPF0696 protein C11orf68 7.4 0.2 4 NADH dehydrogenase iron-sulfur protein 8, mitochondrial 8.1 0.5 20 Tubulin beta-6 chain 7.3 0.3 4 NADH dehydrogenase 1 alpha subcomplex subunit 13 6.3 1

Very-long-chain enoyl-CoA reductase 7.3 0.3 4 Nesprin-1 6.8 1

Neurobeachin-like protein 2 7.3 0.2 4 Neural cell adhesion molecule 2 7.4 0.3 4 Stromal membrane-associated protein 2 7.3 1.2 4 Neural cell adhesion molecule L1 8.2 0.5 20 PRA1 family protein 3 7.2 0.4 4 Neurobeachin-like protein 2 7.3 0.2 4 Creatine kinase U-type, mitochondrial 7.2 0.2 4 Neuroblast differentiation-associated protein AHNAK 6.9 0.4 4 Sorting nexin-18 7.1 0.1 4 Neurocalcin-delta 7.3 0.0 2 Rho-associated protein kinase 2 7.1 0.2 4 Neurochondrin 6.2 0.2 11 Tyrosine-protein kinase CSK 7.1 0.6 4 Neurogranin 7.0 0.2 6 Kinesin light chain 1 7.0 0.4 4 Neuronal membrane glycoprotein M6-a 7.3 0.6 11 Calcium-binding mitochondrial carrier protein Aralar1 7.0 0.3 4 Neuronal pentraxin-1 6.9 0.0 2 Mitogen-activated protein kinase 14 7.0 0.3 4 Neuronal-specific septin-3 7.1 0.3 2 NF-kappa-B essential modulator 7.0 0.2 4 Neuroplastin 7.8 1

Neuroblast differentiation-associated protein AHNAK 6.9 0.4 4 Neurosecretory protein VGF 6.2 0.3 4 Guanine nucleotide-binding protein G(s) subunit alpha isoforms Xlas 6.9 0.2 4 Neutral cholesterol ester hydrolase 1 6.8 0.3 5 Eukaryotic translation initiation factor 3 subunit E 6.9 0.2 4 Neutrophil defensin 1/2/3 6.9 0.3 12 RNA-binding protein 8A 6.9 0.1 4 NF-kappa-B essential modulator 7.0 0.2 4 Bifunctional glutamate/proline--tRNA ligase 6.8 0.1 4 NHP2-like protein 1 7.0 0.1 3 Complexin-2 6.8 0.7 4 Noelin 7.6 0.4 20 C5a anaphylatoxin chemotactic receptor 1 6.8 0.3 4 Non-POU domain-containing octamer-binding protein 7.7 1

Dedicator of cytokinesis protein 2 6.7 0.3 4 N-terminal EF-hand calcium-binding protein 2 7.1 0.0 2 Extended synaptotagmin-1 6.6 0.2 4 Nuclear pore glycoprotein p62 6.9 0.1 2 Paxillin 6.5 0.2 4 Nuclear receptor-binding protein 6.7 0.4 2 Pyruvate dehydrogenase E1 component subunit beta, mitochondrial 6.5 0.4 4 Nucleobindin-2 7.6 0.1 2 Neurosecretory protein VGF 6.2 0.3 4 Nucleosome assembly protein 1-like 1 6.7 0.6 7 Matrix metalloproteinase-16 8.0 0.6 3 Osteoclast-associated immunoglobulin-like receptor 8.2 0.3 19 Arachidonate 5-lipoxygenase-activating protein 7.8 0.4 3 Paralemmin-1 7.3 0.0 2 Apolipoprotein L2 7.7 0.5 3 Paraspeckle component 1 7.6 0.4 20 Bis(5-adenosyl)-triphosphatase ENPP4 7.5 0.0 3 Paxillin 6.5 0.2 4 40S ribosomal protein S8 7.5 0.1 3 PDZ and LIM domain protein 2 6.9 0.0 2 Cytochrome c oxidase subunit 5B, mitochondrial 7.4 0.3 3 PDZ and LIM domain protein 5 6.9 0.3 5 Far upstream element-binding protein 2 7.4 0.4 3 PDZ and LIM domain protein 7 6.6 1

Myelin-associated glycoprotein 7.4 0.5 3 Peptidyl-prolyl cis-trans isomerase FKBP2 7.2 0.8 7 Splicing factor 3A subunit 3 7.4 0.8 3 Peptidyl-prolyl cis-trans isomerase FKBP3 6.9 1

Calcium/calmodulin-dependent protein kinase type II subunit delta 7.4 0.1 3 Peroxisomal multifunctional enzyme type 2 7.3 0.0 2 Protein kinase C alpha/beta type 7.3 0.2 3 Persulfide dioxygenase ETHE1, mitochondrial 8.2 0.5 19 Staphylococcal nuclease domain-containing protein 1 7.3 0.3 3 Phenylalanine--tRNA ligase alpha subunit 6.7 0.2 2 Beta-adrenergic receptor kinase 1 7.3 0.2 3 Phenylalanine--tRNA ligase beta subunit 7.4 0.6 15 Serrate RNA effector molecule homolog 7.3 0.3 3 Phosphatidylinositide phosphatase SAC1 7.1 0.2 5 Transcription elongation factor B polypeptide 1 7.2 0.2 3 Phospholipid-transporting ATPase IA 7.2 0.1 2 Mast cell-expressed membrane protein 1 7.2 0.2 3 Phosphomevalonate kinase 6.6 1

Alanine--tRNA ligase, cytoplasmic 7.2 0.2 3 Phosphopantetheine adenylyltransferase 6.8 0.2 5 tRNA-splicing ligase RtcB homolog 7.1 0.3 3 Phosphoserine aminotransferase 6.9 0.6 15 SAP domain-containing ribonucleoprotein 7.1 0.2 3 Plasma membrane calcium-transporting ATPase 1 6.8 0.1 2 Clathrin light chain B 7.0 0.5 3 Plasma membrane calcium-transporting ATPase 2 7.1 0.2 2 NHP2-like protein 1 7.0 0.1 3 Pleckstrin homology domain-containing family O member 2 7.3 0.5 8 HLA class I histocompatibility antigen, A-68 alpha chain 7.0 0.1 3 Poliovirus receptor 6.6 0.3 7 Serine/arginine-rich splicing factor 11 7.0 0.4 3 Poly(rC)-binding protein 1 7.4 0.3 2 14 kDa phosphohistidine phosphatase 7.0 0.1 3 Poly(rC)-binding protein 2 7.1 1

Ubiquitin carboxyl-terminal hydrolase 7 7.0 0.2 3 Polymeric immunoglobulin receptor 7.8 0.4 19 cAMP-dependent protein kinase type II-beta regulatory subunit 7.0 0.2 3 PRA1 family protein 3 7.2 0.4 4 Profilin-2 6.9 0.3 3 Probable ATP-dependent RNA helicase DDX17 7.7 0.4 16 Ig superfamily member 8 6.9 0.3 3 Probable G-protein coupled receptor 97 6.9 0.4 12 L-selectin 6.9 0.0 3 Probable ubiquitin carboxyl-terminal hydrolase FAF-X 7.4 0.4 20 Synaptophysin 6.9 0.1 3 Profilin-2 6.9 0.3 3 AP-1 complex subunit sigma-2 6.8 0.2 3 Programmed cell death protein 10 7.2 0.4 17 Unconventional myosin-Ig/Minor histocompatibility antigen HA-2 6.8 0.4 3 Proline synthase co-transcribed bacterial homolog protein 7.7 0.8 9 Coiled-coil domain-containing protein 93 6.8 0.3 3 Proline-rich transmembrane protein 2 7.4 0.2 14 Serine-threonine kinase receptor-associated protein 6.8 0.2 3 ProSAAS/KEP/Big SAAS/Little SAAS/Big PEN-LEN/PEN/Little LEN/Big LEN 7.6 0.4 11 Eukaryotic translation initiation factor 3 subunit M 6.7 0.2 3 Proteasome-associated protein ECM29 homolog 6.5 1

Acyl-protein thioesterase 2 6.7 0.1 3 Protein ERGIC-53 7.9 0.5 18 Aspartate carbamoyltransferase 6.7 0.2 3 Protein FAM3C 11.0 0.1 20 Myosin light chain kinase, smooth muscle 6.5 0.3 3 Protein FAM63A 8.5 0.5 19 Regulator of G-protein signaling 19 6.5 0.4 3 Protein flightless-1 homolog 7.7 0.5 20 3-ketoacyl-CoA thiolase, peroxisomal 6.5 0.2 3 Protein Hikeshi 6.8 0.0 2 Gasdermin-D 6.4 0.3 3 Protein kinase C alpha/beta type 7.3 0.2 3 Septin-6 6.4 0.3 3 Protein kinase C delta type 7.6 0.5 20 Tyrosine-protein kinase Fes/Fps 6.4 0.1 3 Protein NDRG1 7.3 0.4 18 Nucleobindin-2 7.6 0.1 2 Protein PML 7.0 1

Ig alpha Fc receptor 7.6 0.2 2 Protein S100-A7A 7.2 1

Abl interactor 1 7.4 0.0 2 Protein THEMIS2 7.8 0.3 19 Poly(rC)-binding protein 1 7.4 0.3 2 Protein transport protein Sec24C 7.0 0.3 11 26S proteasome non-ATPase regulatory subunit 13 7.4 0.2 2 Protein-tyrosine kinase 2-beta 6.7 1

Gephyrin 7.3 0.3 2 P-selectin glycoprotein ligand 1 6.4 1

Peroxisomal multifunctional enzyme type 2 7.3 0.0 2 PTB domain-containing engulfment adapter protein 1 7.2 0.2 2 Paralemmin-1 7.3 0.0 2 Putative heat shock protein HSP 90-beta 4 6.8 0.3 13 Neurocalcin-delta 7.3 0.0 2 Putative pre-mRNA-splicing factor ATP-dependent RNA helicase DHX15 7.9 0.4 16 Myoglobin 7.3 0.1 2 Putative RNA-binding protein Luc7-like 2 7.1 0.4 20 NADH dehydrogenase 1 alpha subcomplex subunit 8 7.2 0.9 2 Putative sodium-coupled neutral amino acid transporter 10 7.6 0.4 19 PTB domain-containing engulfment adapter protein 1 7.2 0.2 2 Pyruvate dehydrogenase E1 component subunit beta, mitochondrial 6.5 0.4 4 Single-stranded DNA-binding protein, mitochondrial 7.2 0.1 2 Rab GTPase-binding effector protein 1 7.2 1

Phospholipid-transporting ATPase IA 7.2 0.1 2 Rab11 family-interacting protein 1 6.7 0.5 9 Cytoplasmic dynein 1 intermediate chain 2 7.2 0.1 2 Rab3 GTPase-activating protein non-catalytic subunit 6.7 0.2 13 ATP-dependent 6-phosphofructokinase, platelet type 7.2 0.2 2 Ragulator complex protein LAMTOR1 6.9 1

Plasma membrane calcium-transporting ATPase 2 7.1 0.2 2 Ragulator complex protein LAMTOR4 7.6 0.2 4 RNA-binding protein Raly 7.1 0.2 2 Rap1 GTPase-GDP dissociation stimulator 1 6.6 0.4 17 Septin-5 7.1 0.3 2 Ras-related protein Rab-14 6.9 1

N-terminal EF-hand calcium-binding protein 2 7.1 0.0 2 Ras-related protein Rab-24 7.3 1

Neuronal-specific septin-3 7.1 0.3 2 Ras-related protein Rab-32 7.8 0.4 5 Early endosome antigen 1 7.1 0.0 2 Ras-related protein Rab-3A 7.8 0.5 18 Thrombospondin-1 7.1 0.2 2 Ras-related protein Rab-3C 8.3 0.4 20 Dematin 7.0 0.1 2 Ras-related protein Rab-44 7.1 0.3 10 Heat shock-related 70 kDa protein 2 7.0 0.0 2 Ras-related protein Rab-6A/6B 7.2 0.2 11 UBX domain-containing protein 1 7.0 0.8 2 Ras-related protein Ral-A 6.9 1

Ganglioside-induced differentiation-associated protein 1 7.0 0.0 2 Ras-related protein Rap-2a 7.3 0.4 8 SH3 domain-containing kinase-binding protein 1 7.0 0.0 2 Regulator of G-protein signaling 19 6.5 0.4 3 Serine/threonine-protein kinase 25 7.0 0.1 2 Renin receptor 6.8 0.5 6 Estradiol 17-beta-dehydrogenase 11 6.9 0.1 2 Replication protein A 14 kDa subunit 7.3 0.4 15 Eukaryotic translation initiation factor 3 subunit I 6.9 0.1 2 Rho guanine nucleotide exchange factor 2 7.0 1

Nuclear pore glycoprotein p62 6.9 0.1 2 Rho-associated protein kinase 2 7.1 0.2 4 COP9 signalosome complex subunit 6 6.9 0.1 2 RNA-binding protein 8A 6.9 0.1 4 PDZ and LIM domain protein 2 6.9 0.0 2 RNA-binding protein Raly 7.1 0.2 2 40S ribosomal protein S16 6.9 0.2 2 Rootletin 6.7 0.2 6 G protein-coupled receptor kinase 6 6.9 0.2 2 RUN and FYVE domain-containing protein 1 6.8 1

Neuronal pentraxin-1 6.9 0.0 2 RuvB-like 1 7.2 0.4 14 Amphiphysin 6.9 0.4 2 Ryanodine receptor 2 6.8 0.3 6 Sister chromatid cohesion protein PDS5 homolog B 6.8 0.0 2 SAP domain-containing ribonucleoprotein 7.1 0.2 3 Sorting nexin-5 6.8 0.2 2 Sarcoplasmic/endoplasmic reticulum calcium ATPase 3 7.0 1

Plasma membrane calcium-transporting ATPase 1 6.8 0.1 2 Secretogranin-2/Secretoneurin 7.1 0.3 18 Protein Hikeshi 6.8 0.0 2 Secretogranin-3 6.2 0.3 5 Phenylalanine--tRNA ligase alpha subunit 6.7 0.2 2 Septin-11 7.9 0.6 15 Nuclear receptor-binding protein 6.7 0.4 2 Septin-4 7.2 0.3 12 Myosin-1/8/13 6.7 0.2 2 Septin-5 7.1 0.3 2 Kinesin-like protein KIF2A 6.5 0.6 2 Septin-6 6.4 0.3 3 Sorting nexin-2 6.4 0.1 2 Serglycin 7.7 0.5 5 Cell adhesion molecule 3 6.4 0.6 2 Serine beta-lactamase-like protein LACTB, mitochondrial 7.3 0.6 17 Ubiquitin-related modifier 1 6.3 0.1 2 Serine/arginine-rich splicing factor 11 7.0 0.4 3 Guanine nucleotide-binding protein subunit alpha-13 6.3 0.2 2 Serine/arginine-rich splicing factor 2/8 6.9 0.3 5 Vacuolar protein sorting-associated protein VTA1 homolog 8.6 1 Serine/arginine-rich splicing factor 7 7.5 0.5 16

Splicing factor 3B subunit 4 8.2 1 Serine/threonine-protein kinase 10 7.9 0.4 20

Diacylglycerol kinase alpha 8.1 1 Serine/threonine-protein kinase 25 7.0 0.1 2

Vesicle-trafficking protein SEC22b 7.9 1 Serine/threonine-protein kinase PAK 2/3 6.9 0.2 7

U6 snRNA-associated Sm-like protein LSm5 7.9 1 Serine-threonine kinase receptor-associated protein 6.8 0.2 3

Syntaxin-binding protein 5 7.8 1 Serrate RNA effector molecule homolog 7.3 0.3 3

Neuroplastin 7.8 1 SH3 domain-containing kinase-binding protein 1 7.0 0.0 2

40S ribosomal protein S2 7.8 1 Sialic acid-binding Ig-like lectin 16 7.3 1

Tetranectin 7.8 1 Signal recognition particle receptor subunit beta 7.5 0.8 7

HD domain-containing protein 2 7.7 1 Signal transducer and activator of transcription 1-alpha/beta 7.2 0.3 12

Non-POU domain-containing octamer-binding protein 7.7 1 Signal transducer and activator of transcription 3 7.9 0.7 19

Astrocytic phosphoprotein PEA-15 7.6 1 Signal transducer and activator of transcription 5A/5B 7.2 1

Microtubule-associated protein RP/EB family member 1 7.6 1 Single-stranded DNA-binding protein, mitochondrial 7.2 0.1 2

NADH dehydrogenase flavoprotein 1, mitochondrial 7.6 1 Sister chromatid cohesion protein PDS5 homolog B 6.8 0.0 2

Limbic system-associated membrane protein 7.6 1 Small glutamine-rich tetratricopeptide repeat-containing protein beta 6.7 1

Aspartate--tRNA ligase, cytoplasmic 7.6 1 Small nuclear ribonucleoprotein Sm D3 7.3 0.1 6

Differentially expressed in FDCP 6 homolog 7.5 1 Sodium/calcium exchanger 2 7.0 1

Ubiquitin-associated protein 2-like 7.5 1 Sodium/potassium-transporting ATPase subunit a-2 7.6 0.6 12

Excitatory amino acid transporter 1 7.5 1 Solute carrier organic anion transporter family member 4C1 6.7 1

Lysosome membrane protein 2 7.5 1 Sorting nexin-18 7.1 0.1 4

Homer protein homolog 1 7.4 1 Sorting nexin-2 6.4 0.1 2

Myosin-10 7.4 1 Sorting nexin-5 6.8 0.2 2

Dynamin-like 120 kDa protein, mitochondrial 7.4 1 Spliceosome RNA helicase DDX39B;ATP-dependent RNA helicase DDX39A 7.0 0.7 16

Extended synaptotagmin-2 7.4 1 Splicing factor 3A subunit 3 7.4 0.8 3

CDK5 regulatory subunit-associated protein 3 7.4 1 Splicing factor 3B subunit 4 8.2 1

Cathepsin Z 7.4 1 Splicing factor U2AF 35 kDa subunit 8.1 0.3 20

B-cell receptor-associated protein 31 7.4 1 Staphylococcal nuclease domain-containing protein 1 7.3 0.3 3

V-type proton ATPase subunit H 7.3 1 Starch-binding domain-containing protein 1 7.6 0.3 17

Ras-related protein Rab-24 7.3 1 Stomatin-like protein 2, mitochondrial 6.9 1

Vesicle-associated membrane protein 8 7.3 1 Stromal cell-derived factor 2-like protein 1 7.0 0.2 5

Sialic acid-binding Ig-like lectin 16 7.3 1 Stromal interaction molecule 1 7.2 0.4 13

GTP-binding protein SAR1a 7.3 1 Stromal membrane-associated protein 2 7.3 1.2 4

EH domain-containing protein 3 7.3 1 Structural maintenance of chromosome flexible hinge domain-containing 1 6.9 0.4 14

26S proteasome non-ATPase regulatory subunit 3 7.3 1 Succinyl-CoA:3-ketoacid coenzyme A transferase 1, mitochondrial 8.4 0.5 20

Lymphoid-restricted membrane protein 7.3 1 Sulfotransferase 1A1/1A2/1A3/1A4 6.5 1

Gamma-parvin 7.3 1 Synapsin-2 7.2 0.4 8

MICOS complex subunit MIC19 7.2 1 Synaptobrevin homolog YKT6 7.3 0.5 5

Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 7.2 1 Synaptogyrin-1 7.0 0.5 12

Clathrin light chain A 7.2 1 Synaptophysin 6.9 0.1 3

Protein S100-A7A 7.2 1 Syntaxin-binding protein 5 7.8 1

Elongation factor 1-alpha 1 7.2 1 TAR DNA-binding protein 43 8.5 0.6 19

Signal transducer and activator of transcription 5A/5B 7.2 1 TATA element modulatory factor 6.4 1

Rab GTPase-binding effector protein 1 7.2 1 Tetranectin 7.8 1

Myelin-oligodendrocyte glycoprotein 7.1 1 Thrombospondin-1 7.1 0.2 2

NADH dehydrogenase iron-sulfur protein 4, mitochondrial 7.1 1 TIP41-like protein 7.2 0.3 7

Poly(rC)-binding protein 2 7.1 1 Titin 7.4 0.3 4

Cysteine and glycine-rich protein 1 7.1 1 Transcription elongation factor B polypeptide 1 7.2 0.2 3

NAD(P) transhydrogenase, mitochondrial 7.1 1 Transcription factor PU.1 7.8 0.9 20

60S ribosomal protein L15 7.0 1 Transgelin-3 8.4 0.6 20

Density-regulated protein 7.0 1 Translocon-associated protein subunit alpha 8.2 0.5 19

FK506-binding protein 15 7.0 1 Translocon-associated protein subunit delta 7.7 0.4 18

Rho guanine nucleotide exchange factor 2 7.0 1 Transmembrane emp24 domain-containing protein 4 7.0 1

Endophilin-A1 7.0 1 Transmembrane protein 109 6.6 0.2 5

C-Jun-amino-terminal kinase-interacting protein 3/4 7.0 1 Transmembrane protein 43 7.7 0.3 6

ATP-dependent 6-phosphofructokinase, muscle type 7.0 1 tRNA-splicing ligase RtcB homolog 7.1 0.3 3

Eukaryotic translation initiation factor 4 gamma 2 7.0 1 Tropomyosin alpha-4 chain 7.7 0.4 20

Protein PML 7.0 1 Tropomyosin beta chain 7.1 0.4 11

Sarcoplasmic/endoplasmic reticulum calcium ATPase 3 7.0 1 Trypsin-1/2 7.1 0.2 5

Transmembrane emp24 domain-containing protein 4 7.0 1 Tubulin alpha chain-like 3 7.3 0.2 8

Tubulin--tyrosine ligase-like protein 12 7.0 1 Tubulin alpha-4A chain 7.2 0.1 6

Sodium/calcium exchanger 2 7.0 1 Tubulin beta-6 chain 7.3 0.3 4

Dynamin-3 7.0 1 Tubulin polymerization-promoting protein family member 3 7.1 0.4 12

Ras-related protein Rab-14 6.9 1 Tubulin--tyrosine ligase-like protein 12 7.0 1

Calcium/calmodulin-dependent protein kinase type II subunit beta 6.9 1 Tyrosine-protein kinase CSK 7.1 0.6 4

E3 ubiquitin-protein ligase TRIM21 6.9 1 Tyrosine-protein kinase Fes/Fps 6.4 0.1 3

Ras-related protein Ral-A 6.9 1 Tyrosine-protein kinase Fgr 7.4 0.6 15

CDGSH iron-sulfur domain-containing protein 1 6.9 1 Tyrosine-protein kinase Lyn 7.6 0.4 13

Stomatin-like protein 2, mitochondrial 6.9 1 U6 snRNA-associated Sm-like protein LSm3 6.7 1

Ficolin-1 6.9 1 U6 snRNA-associated Sm-like protein LSm5 7.9 1

Peptidyl-prolyl cis-trans isomerase FKBP3 6.9 1 Ubiquitin carboxyl-terminal hydrolase 7 7.0 0.2 3

Metallothionein-3 6.9 1 Ubiquitin-associated protein 2-like 7.5 1

ADP/ATP translocase 3 6.9 1 Ubiquitin-conjugating enzyme E2 H 6.8 0.3 8

Ragulator complex protein LAMTOR1 6.9 1 Ubiquitin-related modifier 1 6.3 0.1 2

RUN and FYVE domain-containing protein 1 6.8 1 UBX domain-containing protein 1 7.0 0.8 2

General vesicular transport factor p115 6.8 1 Uncharacterized protein KIAA0513 6.7 1

Nesprin-1 6.8 1 Unconventional myosin-Ig/Minor histocompatibility antigen HA-2 6.8 0.4 3

Protein-tyrosine kinase 2-beta 6.7 1 Unconventional myosin-Va 9.5 0.4 20

Microtubule-associated protein RP/EB family member 2 6.7 1 UPF0568 protein C14orf166 8.0 0.8 12

Small glutamine-rich tetratricopeptide repeat-containing protein beta 6.7 1 UPF0696 protein C11orf68 7.4 0.2 4

Leukotriene B4 receptor 1 6.7 1 Up-regulated during skeletal muscle growth protein 5 6.4 1

Uncharacterized protein KIAA0513 6.7 1 Vacuolar protein sorting-associated protein 29 7.2 0.6 13

High mobility group protein B3 6.7 1 Vacuolar protein sorting-associated protein VTA1 homolog 8.6 1

Solute carrier organic anion transporter family member 4C1 6.7 1 Very long-chain specific acyl-CoA dehydrogenase, mitochondrial 7.2 0.4 5

40S ribosomal protein S3 6.7 1 Very-long-chain enoyl-CoA reductase 7.3 0.3 4

U6 snRNA-associated Sm-like protein LSm3 6.7 1 Vesicle-associated membrane protein 7 7.4 0.3 10

40S ribosomal protein S6 6.6 1 Vesicle-associated membrane protein 8 7.3 1

PDZ and LIM domain protein 7 6.6 1 Vesicle-trafficking protein SEC22b 7.9 1

Phosphomevalonate kinase 6.6 1 V-set and immunoglobulin domain-containing protein 4 7.8 0.4 20

Intercellular adhesion molecule 3 6.6 1 V-type proton ATPase subunit F 8.0 0.6 4

Gamma-soluble NSF attachment protein 6.5 1 V-type proton ATPase subunit H 7.3 1

Sulfotransferase 1A1/1A2/1A3/1A4 6.5 1 WAS/WASL-interacting protein family member 1 8.3 0.4 20

Eukaryotic translation elongation factor 1 epsilon-1 6.5 1 Xaa-Pro aminopeptidase 1 7.4 0.1 4 CAP-Gly domain-containing linker protein 1 6.5 1 14 kDa phosphohistidine phosphatase 7.0 0.1 3

Dystonin 6.5 1 26S proteasome non-ATPase regulatory subunit 13 7.4 0.2 2

Coiled-coil domain-containing protein 88B 6.5 1 26S proteasome non-ATPase regulatory subunit 3 7.3 1

40S ribosomal protein S14 6.5 1 2-oxoglutarate dehydrogenase, mitochondrial 6.6 0.2 7

Proteasome-associated protein ECM29 homolog 6.5 1 3-hydroxyacyl-CoA dehydrogenase type-2 7.1 0.3 10

DnaJ homolog subfamily C member 18 6.5 1 3-ketoacyl-CoA thiolase, peroxisomal 6.5 0.2 3

Up-regulated during skeletal muscle growth protein 5 6.4 1 40S ribosomal protein S14 6.5 1

E3 ubiquitin-protein ligase MYCBP2 6.4 1 40S ribosomal protein S16 6.9 0.2 2

P-selectin glycoprotein ligand 1 6.4 1 40S ribosomal protein S2 7.8 1

TATA element modulatory factor 6.4 1 40S ribosomal protein S3 6.7 1

60S ribosomal protein L23a 6.4 1 40S ribosomal protein S6 6.6 1

DnaJ homolog subfamily C member 8 6.4 1 40S ribosomal protein S7 7.0 0.4 7

NADH dehydrogenase 1 alpha subcomplex subunit 13 6.3 1 40S ribosomal protein S8 7.5 0.1 3

Atlastin-1 6.3 1 60S ribosomal protein L15 7.0 1

LETM1 and EF-hand domain-containing protein 1, mitochondrial 6.3 1 60S ribosomal protein L23a 6.4 1

Calumenin 6.3 1 60S ribosomal protein L6 7.5 0.3 14

DnaJ homolog subfamily C member 5 6.0 1 60S ribosomal protein L7a 7.6 0.5 7

Supplemental Table 4: 1128 proteins in extracellular fluid of subdural empyema (extracerebral pus), arranged according to abundance and alphabetically. Proteins from the extracellular phase of pus from 7 empyemas intracranial, ext racerebral) were analyzed by mass spectrometry. Data are log-10 transformations of raw data from the MS analysis (mean and SD values). Values are calculated from the samples in which a protein was detected; the number of positive samples are given in the column "N". To the left proteins are listed according to their abundance; to the right they are listed alphabetically.

Abundance Alphabetically

Protein Mean SD N Protein Mean SD N

Serum albumin 11.9 0.1 7 Acetyl-CoA carboxylase 1/Biotin carboxylase 7.7 0.4 7

Hemoglobin subunit b 11.4 0.4 7 Acid ceramidase 7.2 0.3 7

Hemoglobin subunit a (HBA1) 11.2 0.5 7 Acidic leucine-rich nuclear phosphoprotein 32 family member A 7.7 0.6 5

Apolipoprotein A-I 11.2 0.2 7 Acidic leucine-rich nuclear phosphoprotein 32 family member B 7.1 1.1 4

Alpha-1-antitrypsin 11.1 0.2 7 Aconitate hydratase, mitochondrial 7.5 1

Alpha-2-macroglobulin 11.1 0.2 7 Actin, alpha skeletal muscle 9.2 0.5 7

Serotransferrin 11.0 0.1 7 Actin, cytoplasmic 1 10.1 0.4 7

Complement C3 10.9 0.3 7 Actin-related protein 2 8.1 0.7 7

Ig gamma-1 chain C region 10.9 0.2 7 Actin-related protein 2/3 complex subunit 1B 7.3 0.7 7

Alpha-1-acid glycoprotein 1 10.8 0.3 7 Actin-related protein 2/3 complex subunit 2 7.9 0.9 7

Ig alpha-1 chain C region 10.8 0.2 7 Actin-related protein 2/3 complex subunit 3 7.5 0.8 7

Protein S100-A9 10.8 0.5 7 Actin-related protein 2/3 complex subunit 4 8.2 0.6 7

Fibrinogen beta chain 10.6 0.3 7 Actin-related protein 2/3 complex subunit 5 8.0 0.6 5

Apolipoprotein B-100 10.6 0.3 7 Actin-related protein 3 8.2 0.7 7

Ig lambda-1 chain C regions 10.5 0.2 7 Activated RNA polymerase II transcriptional coactivator p15 6.7 1

Fibrinogen gamma chain 10.4 0.3 7 Acylamino-acid-releasing enzyme 7.8 0.7 5

Haptoglobin 10.4 0.3 7 Acyl-CoA-binding protein 7.5 0.7 4

Complement C4-B 10.4 0.4 7 Acyl-protein thioesterase 1 7.1 0.1 2

Fibronectin 10.4 0.4 7 Adenine phosphoribosyltransferase 7.0 1.1 2

Transthyretin 10.4 0.2 7 Adenosine deaminase 7.5 0.5 7

Fibrinogen a chain 10.3 0.4 7 Adenosylhomocysteinase 7.8 0.5 6

Ceruloplasmin 10.3 0.3 7 Adenylate kinase 2, mitochondrial 7.7 0.5 4

Ig gamma-2 chain C region 10.2 0.2 7 Adenylate kinase isoenzyme 1 7.6 0.0 2

Protein S100-A8 10.2 0.5 7 Adenylosuccinate lyase 7.2 0.9 7

Apolipoprotein A-IV 10.2 0.3 7 Adenylosuccinate synthetase isozyme 2 7.5 0.8 5

Ig kappa chain V-III region SIE 10.2 0.2 7 Adenylyl cyclase-associated protein 1 8.6 0.7 7

Alpha-1-antichymotrypsin 10.2 0.5 7 Adipocyte plasma membrane-associated protein 7.6 0.1 7

Ig mu chain C region 10.2 0.3 7 Adiponectin 7.4 0.2 7

Antithrombin-III 10.1 0.2 7 ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 2 7.7 0.4 7

Inter-alpha-trypsin-inhibitor heavy chain H4 10.1 0.3 7 ADP-ribosylation factor 1/3 7.6 0.5 6

Hemopexin 10.1 0.2 7 ADP-sugar pyrophosphatase 7.2 0.1 2

Actin, cytoplasmic 1 10.1 0.4 7 Afamin 9.6 0.3 7

Alpha-1-acid glycoprotein 2 10.0 0.3 7 Aflatoxin B1 aldehyde reductase member 2 7.8 0.2 6

Haptoglobin-related protein 10.0 0.3 7 Alcohol dehydrogenase [NADP+] 6.8 0.5 3

Zinc-alpha-2-glycoprotein 10.0 0.3 7 Aldehyde dehydrogenase family 16 member A1 6.9 1.1 7

Plasma protease C1 inhibitor 9.9 0.3 7 Alkaline phosphatase, tissue-nonspecific isozyme 6.7 0.8 4

Vitamin D-binding protein 9.9 0.1 7 Allograft inflammatory factor 1 7.2 0.5 5

Alpha-1B-glycoprotein 9.9 0.2 7 Alpha/beta-soluble NSF attachment protein 6.3 1

Hemoglobin subunit delta 9.9 0.6 7 Alpha-1-acid glycoprotein 1 10.8 0.3 7

Ig lambda-2 chain C regions 9.9 0.3 7 Alpha-1-acid glycoprotein 2 10.0 0.3 7

Alpha-2-HS-glycoprotein 9.8 0.1 7 Alpha-1-antichymotrypsin 10.2 0.5 7

Histidine-rich glycoprotein 9.8 0.2 7 Alpha-1-antitrypsin 11.1 0.2 7

Complement factor B 9.8 0.5 7 Alpha-1B-glycoprotein 9.9 0.2 7

Peroxiredoxin-2 9.8 0.7 7 Alpha-2-antiplasmin 9.5 0.4 7

Clusterin 9.8 0.4 7 Alpha-2-HS-glycoprotein 9.8 0.1 7

Apolipoprotein A-II 9.8 0.4 7 Alpha-2-macroglobulin 11.1 0.2 7

Angiotensinogen/Angiotensin 9.8 0.3 7 Alpha-actinin-1 9.2 0.9 7

Plastin-2 9.8 0.5 7 Alpha-actinin-4 8.6 1.0 7

Gelsolin 9.8 0.2 7 Alpha-adducin 7.3 0.8 3

Inter-alpha-trypsin inhibitor heavy chain H2 9.8 0.2 7 Alpha-crystallin B chain 6.7 0.3 2

Apolipoprotein E 9.8 0.1 7 Alpha-endosulfine 6.1 1

Inter-alpha-trypsin inhibitor heavy chain H1 9.7 0.3 7 Alpha-enolase 9.1 0.6 7

Ig kappa chain V-IV region Len 9.7 0.3 7 Alpha-hemoglobin-stabilizing protein 6.9 0.8 5

Leucine-rich alpha-2-glycoprotein 9.7 0.4 7 Alpha-internexin 8.0 1

Bradykinin 9.7 0.2 7 Alpha-synuclein 6.8 0.7 6

Ig kappa chain V-II region GM607 9.6 0.2 7 Aminopeptidase B 7.6 0.4 4

Catalase 9.6 0.5 7 Aminopeptidase N 7.8 0.5 7

Vimentin 9.6 0.5 7 AMP deaminase 3 7.0 0.7 5

Myeloperoxidase 9.6 0.7 7 Amyloid beta A4 protein 6.2 0.0 2

Lactotransferrin 9.6 0.8 7 Angiotensinogen/Angiotensin 9.8 0.3 7

Ig kappa chain V-I region WEA 9.6 0.2 7 Ankyrin repeat domain-containing protein 36A/B 5.8 0.1 3

Afamin 9.6 0.3 7 Ankyrin-1 8.0 1.2 5

Histone H2B 9.6 0.8 7 Annexin A1 9.2 1.0 7

C4b-binding protein alpha chain 9.5 0.3 7 Annexin A11 7.5 0.7 6

Complement C5 9.5 0.3 7 Annexin A2 7.5 0.5 5

Ig gamma-3 chain C region 9.5 0.1 7 Annexin A3 8.4 1.1 7

Ig heavy chain V-III region BRO 9.5 0.3 7 Annexin A4 7.3 0.8 7

Carbonic anhydrase 1 9.5 0.7 7 Annexin A5 7.9 1.5 5

Vitronectin 9.5 0.4 7 Annexin A6 7.7 1.1 6

Glyceraldehyde-3-phosphate dehydrogenase 9.5 0.5 7 Annexin A7 7.8 0.3 7

Complement factor H 9.5 0.2 7 Antithrombin-III 10.1 0.2 7

Trypstatin 9.5 0.3 7 AP-1 complex subunit beta-1 7.0 0.6 5

Alpha-2-antiplasmin 9.5 0.4 7 AP-2 complex subunit b 7.0 0.5 2

Histone H2A type 1-J 9.4 0.8 7 AP-2 complex subunit m 7.0 0.2 2

Heparin cofactor 2 9.4 0.3 7 Apolipoprotein A-I 11.2 0.2 7

Pigment epithelium-derived factor 9.4 0.2 7 Apolipoprotein A-II 9.8 0.4 7

Ig heavy chain V-III region TIL 9.3 0.3 7 Apolipoprotein A-IV 10.2 0.3 7

Ig kappa chain V-III region NG9 9.3 0.2 7 Apolipoprotein B receptor 7.8 0.6 6

Complement component C9 9.3 0.5 7 Apolipoprotein B-100 10.6 0.3 7

Ig lambda chain V-I region WAH 9.3 0.3 7 Apolipoprotein C-I 9.1 0.3 7

Phospholipid transfer protein 9.3 0.3 7 Apolipoprotein C-II 8.7 0.8 7

Histone H4 9.3 0.9 7 Apolipoprotein C-III 9.1 0.7 7

Ig lambda variable 3-21 9.3 0.2 7 Apolipoprotein D 9.2 0.3 7

Ferritin light chain 9.3 0.4 7 Apolipoprotein E 9.8 0.1 7

Serum amyloid P-component 9.3 0.3 7 Apolipoprotein F 8.3 0.5 7

Lumican 9.2 0.2 7 Apolipoprotein L1 9.0 0.4 7

Serum paraoxonase/arylesterase 1 9.2 0.2 7 Apolipoprotein M 8.7 0.3 7

Alpha-actinin-1 9.2 0.9 7 Apoptosis inhibitor 5 7.0 1.1 2

Actin, alpha skeletal muscle 9.2 0.5 7 Apoptosis-associated speck-like protein containing a CARD 7.9 0.7 7

Prothrombin 9.2 0.4 7 Arachidonate 5-lipoxygenase 7.0 0.4 5

Annexin A1 9.2 1.0 7 Arginase-1 8.4 0.3 4

Apolipoprotein D 9.2 0.3 7 Argininosuccinate lyase 7.5 0.4 4

Ig gamma-4 chain C region 9.2 0.5 7 Aspartate aminotransferase, cytoplasmic 7.9 0.7 6

Corticosteroid-binding globulin 9.2 0.2 7 Aspartate aminotransferase, mitochondrial 7.5 0.6 5

Fructose-bisphosphate aldolase A 9.2 0.4 7 Aspartyl aminopeptidase 7.2 0.5 4

Myosin-9 9.1 0.8 7 ATP synthase subunit alpha, mitochondrial 7.1 1

Apolipoprotein C-III 9.1 0.7 7 ATP synthase subunit beta, mitochondrial 7.5 1

14-3-3 protein z/d 9.1 0.6 7 ATP synthase subunit d, mitochondrial 6.0 0.3 3

Alpha-enolase 9.1 0.6 7 ATPase ASNA1 6.9 1.0 2

Transketolase 9.1 0.6 7 ATP-binding cassette sub-family B member 6, mitochondrial 6.0 0.6 4

Apolipoprotein C-I 9.1 0.3 7 ATP-binding cassette sub-family B member 9 8.4 0.4 7

L-lactate dehydrogenase A chain 9.1 0.5 7 ATP-citrate synthase 7.1 0.6 6

Ig kappa chain V-I region EU 9.1 0.4 7 ATP-dependent dihydroxyacetone kinase/FAD-AMP lyase 7.0 1.1 4

WAP four-disulfide core domain protein 3 9.1 0.3 7 ATP-dependent RNA helicase DDX39A 7.2 0.2 2

Band 3 anion transport protein 9.1 0.8 7 Attractin 8.2 0.3 7

Complement factor I 9.1 0.4 7 Azurocidin 8.3 1.0 7

Glucose-6-phosphate isomerase 9.0 0.6 7 Bactericidal permeability-increasing protein 8.0 1.1 7

Moesin 9.0 0.5 7 Band 3 anion transport protein 9.1 0.8 7

Ig heavy variable 3/OR16-13 9.0 0.3 7 Barrier-to-autointegration factor 7.2 0.1 2

Neutrophil cytosol factor 4 9.0 0.8 7 Beta-2-glycoprotein 1 8.7 0.2 7

Ig lambda chain V-IV region Hil 9.0 0.3 7 Beta-2-microglobulin 7.2 0.4 7

Ig lambda chain V-III region LOI 9.0 0.4 7 Beta-actin-like protein 2 7.4 0.2 2

Transforming growth factor-b-induced protein ig-h3 9.0 0.3 7 Beta-adducin 7.1 1

Ferritin heavy chain 9.0 0.4 7 Beta-Ala-His dipeptidase 7.9 0.3 7

Apolipoprotein L1 9.0 0.4 7 Beta-glucuronidase 7.2 0.6 4

6-phosphogluconate dehydrogenase 8.9 0.6 7 Beta-hexosaminidase subunit b 6.8 0.5 6

Inter-alpha-trypsin inhibitor heavy chain H3 8.9 0.4 7 BH3-interacting domain death agonist 6.8 0.9 6

Phosphoglycerate kinase 1 8.9 0.5 7 Bifunctional purine biosynthesis protein PURH 6.9 0.8 2

Monocyte differentiation antigen CD14 8.9 0.2 7 Biotinidase 8.1 0.3 7

Plasminogen 8.9 0.4 7 Bisphosphoglycerate mutase 8.1 0.8 7

Ig kappa chain V-III region VG 8.9 0.5 7 Bleomycin hydrolase 7.3 0.6 5

Ig kappa chain V-I region Ni 8.9 0.3 7 Blood group Rh(D/C/E) polypeptide 7.7 0.3 5

Pyruvate kinase (PKM3) 8.9 0.7 7 Bradykinin 9.7 0.2 7

Retinol-binding protein 4 8.9 0.2 7 Brain acid soluble protein 1 8.2 0.6 7

Ig lambda chain V-III region SH 8.9 0.2 7 Bridging integrator 2 7.5 0.8 5

Transaldolase 8.9 0.5 7 BTB/POZ domain-containing protein KCTD12 7.5 0.4 5

Vinculin 8.9 0.5 7 C4b-binding protein alpha chain 9.5 0.3 7

Ig heavy chain V-III region KOL 8.9 0.2 7 C4b-binding protein beta chain 8.1 0.3 7

Lipopolysaccharide-binding protein 8.9 0.5 7 Cadherin-1 7.0 1

Leukotriene A-4 hydrolase 8.9 0.5 7 Cadherin-13 7.1 0.4 7

Neutrophil gelatinase-associated lipocalin 8.9 0.5 7 Cadherin-5 7.7 0.2 6

Insulin-like growth factor-binding protein complex acid labile subunit 8.9 0.4 7 Calcineurin B homologous protein 1 6.4 0.7 3

Complement component C6 8.8 0.4 7 Calcineurin subunit B type 1 6.8 1

Histone H3 8.8 0.9 7 Calcium uniporter protein, mitochondrial 7.3 0.3 2

Ig heavy chain V-I region V35 8.8 0.4 7 Calcium/calmodulin-dependent protein kinase type II subunit g 6.9 1

Complement component C8 a chain 8.8 0.3 7 Calcium-binding protein 39 7.5 0.6 5

Plasma kallikrein 8.8 0.2 7 Calmodulin 8.7 0.5 7

Sec1 family domain-containing protein 1 8.8 0.5 7 Calnexin 6.6 0.2 5

Serum amyloid A-4 protein 8.8 0.3 7 Calpain small subunit 1 7.5 0.5 6

Ig alpha-2 chain C region 8.8 0.4 7 Calpain-1 catalytic subunit 8.1 0.6 7

Coagulation factor XII 8.8 0.3 7 Calpain-2 catalytic subunit 7.9 1

Carboxypeptidase N subunit 2 8.8 0.3 7 Calpastatin 7.1 0.6 5

Vitamin K-dependent protein S 8.8 0.3 7 Calponin-2 7.9 0.4 4

Triosephosphate isomerase 8.8 0.5 7 Calreticulin 7.6 0.5 7

Peroxiredoxin-6 8.7 0.6 7 Calretinin 6.7 1

L-lactate dehydrogenase B chain 8.7 0.4 7 Calsyntenin-1 6.3 0.1 2

Beta-2-glycoprotein 1 8.7 0.2 7 cAMP-dependent protein kinase type I-a regulatory subunit 7.4 0.7 5

Rab GDP dissociation inhibitor beta 8.7 0.6 7 cAMP-dependent protein kinase type II-a regulatory subunit 6.6 0.6 2

C-reactive protein 8.7 0.8 7 CapZ-interacting protein 7.0 0.6 5

Complement component C8 b chain 8.7 0.3 7 Carbonic anhydrase 1 9.5 0.7 7

Galectin-3-binding protein 8.7 0.2 7 Carbonic anhydrase 2 8.6 0.8 7

Leukocyte elastase inhibitor 8.7 0.5 7 Carboxypeptidase B2 7.8 0.3 7

Profilin-1 8.7 0.5 7 Carboxypeptidase N catalytic chain 8.7 0.4 7

Thioredoxin 8.7 0.4 7 Carboxypeptidase N subunit 2 8.8 0.3 7

Calmodulin 8.7 0.5 7 Carcinoembryonic antigen-related cell adhesion molecule 1 7.1 0.6 4

Filamin-A 8.7 0.7 7 Carcinoembryonic antigen-related cell adhesion molecule 6 7.3 0.7 5

Apolipoprotein C-II 8.7 0.8 7 Carcinoembryonic antigen-related cell adhesion molecule 8 7.7 0.6 7

Kallistatin 8.7 0.3 7 Caspase recruitment domain-containing protein 9 7.6 0.4 3

Coronin-1A 8.7 0.4 7 Catalase 9.6 0.5 7

Apolipoprotein M 8.7 0.3 7 Cathelicidin antimicrobial peptide LL-37 8.3 0.7 7

Ig J chain 8.7 0.3 7 Cathepsin B 8.0 0.4 7

Myeloblastin 8.7 0.6 7 Cathepsin D 7.3 0.4 7

Hemoglobin subunit gamma-1 8.7 0.8 7 Cathepsin G 8.4 0.5 7

Carboxypeptidase N catalytic chain 8.7 0.4 7 Cathepsin L1 6.9 0.4 5

Spectrin alpha chain, erythrocytic 1 8.6 0.9 7 Cathepsin S 7.2 0.3 4

Adenylyl cyclase-associated protein 1 8.6 0.7 7 CD109 antigen 6.1 0.9 2

Collagen alpha-1(I) chain 8.6 0.1 7 CD44 antigen 7.8 0.2 7

Alpha-actinin-4 8.6 1.0 7 CD63 antigen 7.1 0.3 4

Ig kappa chain V-I region Wes 8.6 0.2 7 CD97 antigen 6.8 0.3 2

Carbonic anhydrase 2 8.6 0.8 7 Cell division control protein 42 homolog 7.5 0.9 6

Peptidyl-prolyl cis-trans isomerase A 8.6 0.4 7 Ceruloplasmin 10.3 0.3 7

Glutathione peroxidase 3 8.6 0.2 7 Charged multivesicular body protein 4a 6.9 1

Ig kappa chain V-I region Roy 8.6 0.4 7 Charged multivesicular body protein 4b 5.6 1

Pentraxin-related protein PTX3 8.6 0.5 7 Chitinase-3-like protein 1/YKL-40 8.1 0.6 7

Purine nucleoside phosphorylase 8.6 0.6 7 Chitotriosidase-1 8.2 0.8 5

Complement C1q subcomponent subunit C 8.6 0.3 7 Chloride intracellular channel protein 1 7.8 0.7 7

Complement C2 8.6 0.4 7 Cholesteryl ester transfer protein 7.2 0.5 6

Protein S100-P 8.6 0.8 7 Cholinesterase 8.3 0.3 7

Complement C1r subcomponent 8.6 0.4 7 Chromobox protein homolog 3 7.1 0.5 3

Ig heavy chain V-III region GAL 8.5 0.3 7 Chromogranin-A 7.5 0.7 4

Phosphoglycerate mutase 1 8.5 0.5 7 Citrate synthase 6.3 0.9 2

Ig kappa chain V-III region B6 8.5 0.4 7 Clathrin heavy chain 1 7.5 0.6 5

Thymosin b-4 8.5 0.4 7 Clusterin 9.8 0.4 7

Complement component C8 gamma chain 8.5 0.3 7 Coactosin-like protein 7.7 0.6 7

Talin-1 8.5 1.0 7 Coagulation factor V 7.4 0.5 7

Matrix metalloproteinase-9 8.5 1.1 7 Coagulation factor X 7.6 0.4 5

Protein S100-A12 8.5 1.2 7 Coagulation factor XII 8.8 0.3 7

Versican core protein 8.5 0.2 7 Coagulation factor XIII B chain 7.4 0.2 6

Ubiquitin-60S ribosomal protein L40 8.5 0.6 7 Coatomer subunit b 6.2 0.3 2

Spectrin beta chain, erythrocytic 8.5 1.0 7 Cofilin-1 8.4 0.6 7

Nicotinamide phosphoribosyltransferase 8.5 0.8 7 Coiled-coil domain-containing protein 150 6.1 1

Collagen alpha-3(VI) chain 8.5 0.2 7 Collagen alpha-1(I) chain 8.6 0.1 7

Glutathione S-transferase P 8.5 0.6 7 Collagen alpha-1(III) chain 8.4 0.3 7

Heat shock 70 kDa protein 1A/1B 8.5 0.5 7 Collagen alpha-1(V) chain 7.6 0.5 6

Ig lambda variable 6-57 8.4 0.3 7 Collagen alpha-1(VI) chain 8.2 0.2 7

Cofilin-1 8.4 0.6 7 Collagen alpha-1(VII) chain 8.0 1

Hemoglobin subunit alpha (HBA2) 8.4 0.6 7 Collagen alpha-1(XII) chain 7.2 0.8 7

Ig lambda variable 3-25 8.4 0.4 7 Collagen alpha-1(XIV) chain 8.6 0.7 3

Protein S100-A4 8.4 0.5 7 Collagen alpha-1(XVIII) chain 7.1 0.3 3

DNA primase large subunit 8.4 0.6 7 Collagen alpha-2(I) chain 8.3 0.2 7

Prostaglandin-H2 D-isomerase 8.4 0.6 7 Collagen alpha-2(IV) chain 6.7 0.1 2

Complement component C7 8.4 0.4 7 Collagen alpha-2(V) chain 7.4 0.4 7

Complement C4-A 8.4 0.5 7 Collagen alpha-3(VI) chain 8.5 0.2 7

Extracellular matrix protein 1 8.4 0.2 7 Complement C1q subcomponent subunit A 7.4 0.4 7

Ig kappa chain V-III region CLL 8.4 0.5 7 Complement C1q subcomponent subunit B 8.3 0.3 7

Thyroxine-binding globulin 8.4 0.2 7 Complement C1q subcomponent subunit C 8.6 0.3 7

ATP-binding cassette sub-family B member 9 8.4 0.4 7 Complement C1r subcomponent 8.6 0.4 7

14-3-3 protein epsilon 8.4 0.5 7 Complement C1r subcomponent-like protein 7.6 0.3 7

Annexin A3 8.4 1.1 7 Complement C1s subcomponent 8.3 0.5 7

Collagen alpha-1(III) chain 8.4 0.3 7 Complement C2 8.6 0.4 7

Superoxide dismutase [Mn], mitochondrial 8.4 0.5 7 Complement C3 10.9 0.3 7

Protein S100-A6 8.4 0.9 7 Complement C4-A 8.4 0.5 7

Cathepsin G 8.4 0.5 7 Complement C4-B 10.4 0.4 7

Osteopontin 8.4 0.4 7 Complement C5 9.5 0.3 7

Ig lambda chain V-I region VOR 8.3 0.3 7 Complement component C6 8.8 0.4 7

Ig heavy chain V-II region ARH-77 8.3 0.6 7 Complement component C7 8.4 0.4 7

Myosin light polypeptide 6 8.3 0.7 7 Complement component C8 a chain 8.8 0.3 7

Apolipoprotein F 8.3 0.5 7 Complement component C8 b chain 8.7 0.3 7

Ig kappa chain V-I region BAN 8.3 0.2 7 Complement component C8 gamma chain 8.5 0.3 7

Complement C1q subcomponent subunit B 8.3 0.3 7 Complement component C9 9.3 0.5 7

Heat shock protein HSP 90-a 8.3 0.6 7 Complement factor B 9.8 0.5 7

Collagen alpha-2(I) chain 8.3 0.2 7 Complement factor D 7.9 0.5 7

Spectrin alpha chain, non-erythrocytic 1 8.3 1.1 7 Complement factor H 9.5 0.2 7

Lysozyme C 8.3 0.4 7 Complement factor H-related protein 1/2 8.1 0.3 7

Cystatin-C 8.3 0.5 7 Complement factor I 9.1 0.4 7

Complement C1s subcomponent 8.3 0.5 7 Complement receptor type 1 6.7 0.6 3

Ficolin-3 8.3 0.3 7 COP9 signalosome complex subunit 3 5.4 0.6 2

Transitional endoplasmic reticulum ATPase 8.3 0.7 7 COP9 signalosome complex subunit 4 7.0 0.2 2

Cathelicidin antimicrobial peptide LL-37 8.3 0.7 7 COP9 signalosome complex subunit 5 6.9 0.6 6

Ig lambda chain V-II region NIG-84 8.3 0.3 7 Copine-3 7.5 0.3 5

Cholinesterase 8.3 0.3 7 Core histone macro-H2A.1 8.3 0.9 4

Phosphatidylinositol-glycan-specific phospholipase D 8.3 0.4 7 Coronin-1A 8.7 0.4 7

Serine/threonine-protein phosphatase CPPED1 8.3 0.5 7 Coronin-1C 6.4 0.4 4

Azurocidin 8.3 1.0 7 Corticosteroid-binding globulin 9.2 0.2 7

Ig lambda variable 8-61 8.3 0.4 7 Costars family protein ABRACL 7.6 0.8 5

Ig lambda variable 16-47 8.2 0.1 7 C-reactive protein 8.7 0.8 7

Ig kappa chain V-I region DEE 8.2 0.4 7 Creatine kinase B-type 6.6 0.3 5

Collagen alpha-1(VI) chain 8.2 0.2 7 Crk-like protein 7.0 0.1 2

Actin-related protein 3 8.2 0.7 7 CTP synthase 1 6.5 1

Rho GDP-dissociation inhibitor 2 8.2 0.8 7 C-type lectin domain family 11 member A 6.6 0.2 3 von Willebrand factor 8.2 0.3 7 Cullin-1 8.0 0.3 7

Histone H1.4 8.2 0.4 7 Cullin-2 6.0 0.2 3

Plasminogen activator inhibitor 1 8.2 0.3 7 Cullin-3 7.4 0.2 2

Attractin 8.2 0.3 7 Cullin-4B 5.7 1

Actin-related protein 2/3 complex subunit 4 8.2 0.6 7 Cullin-associated NEDD8-dissociated protein 1 8.1 0.8 6

Vasorin 8.2 0.6 7 Cystatin-A 8.1 1.0 5

Brain acid soluble protein 1 8.2 0.6 7 Cystatin-B 7.1 0.7 4

Malate dehydrogenase, cytoplasmic 8.2 0.7 7 Cystatin-C 8.3 0.5 7

Erythrocyte band 7 integral membrane protein 8.2 0.5 7 Cysteine-rich secretory protein 3 5.8 1

Macrophage-capping protein 8.2 0.6 7 Cytidine deaminase 7.3 0.7 3

Protein S100-A11 8.2 0.9 7 Cytochrome b-245 light chain 6.6 1

Lysosome-associated membrane glycoprotein 2 8.2 0.4 7 Cytochrome b5 7.4 0.3 3

Metalloproteinase inhibitor 1 8.2 0.3 7 Cytochrome c 7.1 0.9 6

78 kDa glucose-regulated protein 8.2 0.4 7 Cytochrome c oxidase subunit 4 isoform 1, mitochondrial 6.7 1

14-3-3 protein a/b 8.2 0.7 7 Cytochrome P450 4X1 6.5 1

Ig lambda chain V region 4A 8.2 0.4 7 Cytokine receptor-like factor 3 6.6 0.3 3

N-acetylmuramoyl-L-alanine amidase 8.2 0.8 7 Cytoplasmic FMR1-interacting protein 2 6.5 0.7 3

Proteasome subunit a type-1 8.2 0.5 7 Cytoskeleton-associated protein 4 5.6 1

Biotinidase 8.1 0.3 7 Cytosol aminopeptidase 6.9 0.5 2

C4b-binding protein beta chain 8.1 0.3 7 Cytosolic non-specific dipeptidase 6.7 0.5 6

Ig heavy chain V-III region BUT 8.1 0.3 7 Cytosolic purine 5-nucleotidase 7.5 0.6 4

Glycogen phosphorylase, liver form 8.1 0.8 7 D-dopachrome decarboxylase 8.0 0.4 7

Complement factor H-related protein 1/2 8.1 0.3 7 Delta(3,5)-Delta(2,4)-dienoyl-CoA isomerase, mitochondrial 7.0 1

Ig lambda variable 2-14 8.1 0.7 7 Delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial 7.1 1

Proteasome activator complex subunit 1 8.1 0.5 7 Delta-aminolevulinic acid dehydratase 8.4 0.5 6

Sulfhydryl oxidase 1 8.1 0.1 7 Desmoplakin 7.8 1

Ig lambda chain V-II region BUR 8.1 0.5 7 Dickkopf-related protein 3 7.4 1

SPARC 8.1 0.6 7 Dihydrolipoyl dehydrogenase, mitochondrial 7.0 0.6 4

Proteasome subunit b type-2 8.1 0.7 7 Dihydropteridine reductase 6.5 1

Ig lambda chain V-I region NIG-64 8.1 0.1 7 Dihydropyrimidinase-related protein 1 6.6 1

Bisphosphoglycerate mutase 8.1 0.8 7 Dihydropyrimidinase-related protein 2 6.7 1.1 3

Ig lambda variable 3-10 8.1 0.3 7 Dihydropyrimidine dehydrogenase [NADP(+)] 7.0 1

Chitinase-3-like protein 1/YKL-40 8.1 0.6 7 Di-N-acetylchitobiase 6.5 0.3 5

Follistatin-related protein 1 8.1 0.3 7 Dipeptidyl peptidase 1 6.6 1.0 3

Glutathione S-transferase omega-1 8.1 0.4 7 Dipeptidyl peptidase 3 7.3 0.6 6

Proteasome subunit a type-7 8.1 0.7 7 DNA primase large subunit 8.4 0.6 7

Phosphatidylcholine-sterol acyltransferase 8.1 0.1 7 DNA topoisomerase 2 7.0 0.1 2

Calpain-1 catalytic subunit 8.1 0.6 7 DNA-(apurinic or apyrimidinic site) lyase 7.6 0.7 4

Selenoprotein P 8.1 0.5 7 DNA-binding protein RFX7 7.0 0.7 2

Ig lambda-like polypeptide 1 8.1 0.4 7 DnaJ homolog subfamily C member 13 6.8 0.3 2

F-actin-capping protein subunit b 8.1 0.6 7 Dopamine beta-hydroxylase 7.8 0.3 7

Actin-related protein 2 8.1 0.7 7 Drebrin-like protein 6.4 0.8 5

Ras GTPase-activating-like protein IQGAP1 8.1 1.1 7 Dynactin subunit 1 7.2 0.8 5

Endorepellin 8.1 0.4 7 Dynactin subunit 2 7.5 0.5 3

Ig lambda variable 3-9 8.0 0.3 7 Dynein heavy chain 8, axonemal 7.8 0.4 7

Tenascin 8.0 0.3 7 Dysferlin 6.4 1.3 4

Hypoxanthine-guanine phosphoribosyltransferase 8.0 0.5 7 E3 ubiquitin-protein ligase CBL 6.5 0.7 2

Tubulin b-4B chain 8.0 0.5 7 Echinoderm microtubule-associated protein-like 2 7.5 0.2 2

Plasma serine protease inhibitor 8.0 0.2 7 Echinoderm microtubule-associated protein-like 4 6.3 1

Cathepsin B 8.0 0.4 7 Ectonucleotide pyrophosphatase/phosphodiesterase family member 2 7.2 0.4 4

Histone H1.5 8.0 0.7 7 EF-hand domain-containing protein D2 7.8 0.8 7

Ig heavy chain V-II region WAH 8.0 0.2 7 EH domain-containing protein 1 7.0 0.3 4

Cullin-1 8.0 0.3 7 Electron transfer flavoprotein subunit b 6.9 0.4 4

Ig delta chain C region 8.0 0.7 7 Elongation factor 1-a 1/2 7.4 0.3 4

Protein Z-dependent protease inhibitor 8.0 0.4 7 Elongation factor 1-b 7.0 0.1 2

D-dopachrome decarboxylase 8.0 0.4 7 Elongation factor 1-d 7.2 0.8 5

Nucleoside diphosphate kinase 8.0 0.6 7 Elongation factor 1-g 7.4 0.5 5

Ig lambda chain V-I region NEW 8.0 0.5 7 Elongation factor 2 7.7 1.0 7

Lamin-B1 8.0 0.7 7 Elongation factor Tu, mitochondrial 5.4 1

Bactericidal permeability-increasing protein 8.0 1.1 7 Endoplasmic reticulum aminopeptidase 1 6.4 0.1 2

Beta-Ala-His dipeptidase 7.9 0.3 7 Endoplasmic reticulum resident protein 29 7.3 0.6 6

Peptidyl-prolyl cis-trans isomerase FKBP1A 7.9 0.8 7 Endoplasmin 7.3 0.5 7

Heat shock cognate 71 kDa protein 7.9 0.7 7 Endorepellin 8.1 0.4 7

Sex hormone-binding globulin 7.9 0.3 7 Enhancer of rudimentary homolog 7.0 0.2 3

Apoptosis-associated speck-like protein containing a CARD 7.9 0.7 7 Enolase-phosphatase E1 6.6 0.3 2

Actin-related protein 2/3 complex subunit 2 7.9 0.9 7 Eosinophil cationic protein 8.3 0.6 6

Flavin reductase (NADPH) 7.9 1.0 7 Eosinophil peroxidase 6.7 0.5 2

Complement factor D 7.9 0.5 7 Epidermal growth factor receptor substrate 15 6.7 0.4 5

Proteasome subunit alpha type-5 7.9 0.7 7 Epidermal growth factor receptor substrate 15-like 1 6.6 0.4 3

Proteasome subunit alpha type-4 7.9 0.5 7 Erlin-1 6.6 1

Fetuin-B 7.9 0.4 7 Erlin-2 7.1 1

SH3 domain-binding glutamic acid-rich-like protein 3 7.9 0.5 7 ERO1-like protein a 7.1 0.6 4

Ig kappa chain V-III region POM 7.9 0.3 7 Erythrocyte band 7 integral membrane protein 8.2 0.5 7

Proteoglycan 4 7.8 0.5 7 Erythrocyte membrane protein band 4.2 7.4 0.7 7

Vesicle transport through interaction with t-SNAREs homolog 1B 7.8 0.4 7 Ester hydrolase C11orf54 7.6 1

EF-hand domain-containing protein D2 7.8 0.8 7 Eukaryotic initiation factor 4A-I 6.9 0.8 3

Aminopeptidase N 7.8 0.5 7 Eukaryotic translation initiation factor 2 subunit 1 6.1 0.1 2

Hyaluronan-binding protein 2 7.8 0.3 7 Eukaryotic translation initiation factor 3 subunit J 6.4 1

Annexin A7 7.8 0.3 7 Eukaryotic translation initiation factor 4B 6.4 0.3 4

Dynein heavy chain 8, axonemal 7.8 0.4 7 Eukaryotic translation initiation factor 5A-1 7.0 0.4 5

Glucose-6-phosphate 1-dehydrogenase 7.8 0.9 7 Exportin-1 7.2 1

WD repeat-containing protein 1 7.8 0.4 7 Exportin-2 7.4 1.5 5

Platelet glycoprotein Ib a chain 7.8 0.2 7 Exportin-7 7.1 1

CD44 antigen 7.8 0.2 7 Extracellular matrix protein 1 8.4 0.2 7

Tryptophan--tRNA ligase, cytoplasmic 7.8 0.4 7 Extracellular superoxide dismutase [Cu-Zn] 7.6 0.3 7

Serpin B10 7.8 0.8 7 Ezrin 7.6 0.5 6

Ig heavy chain V-III region LAY 7.8 0.6 7 F-actin-capping protein subunit a-1 8.0 0.9 6

Glutathione reductase, mitochondrial 7.8 0.6 7 F-actin-capping protein subunit a-2 6.9 1.0 5

Carboxypeptidase B2 7.8 0.3 7 F-actin-capping protein subunit b 8.1 0.6 7

Neutrophil elastase 7.8 1.0 7 Far upstream element-binding protein 1 7.1 0.0 3

Chloride intracellular channel protein 1 7.8 0.7 7 Farnesyl pyrophosphate synthase 7.4 0.6 4

Protein disulfide-isomerase A3 7.8 0.3 7 Fascin 5.4 1

Ig lambda chain V-V region DEL 7.8 0.4 7 Fatty acid-binding protein, epidermal 7.4 0.5 7

Dopamine beta-hydroxylase 7.8 0.3 7 Fatty acid-binding protein, heart 6.5 0.6 3

SH3 domain-binding glutamic acid-rich-like protein 7.8 0.5 7 F-box only protein 7 7.0 0.0 2

Acetyl-CoA carboxylase 1/Biotin carboxylase 7.7 0.4 7 Ferritin heavy chain 9.0 0.4 7

Carcinoembryonic antigen-related cell adhesion molecule 8 7.7 0.6 7 Ferritin light chain 9.3 0.4 7

Coactosin-like protein 7.7 0.6 7 Fetuin-B 7.9 0.4 7

Ubiquitin-conjugating enzyme E2 N 7.7 0.6 7 Fibrinogen a chain 10.3 0.4 7

Isocitrate dehydrogenase [NADP] cytoplasmic 7.7 0.6 7 Fibrinogen beta chain 10.6 0.3 7

Grancalcin 7.7 0.8 7 Fibrinogen gamma chain 10.4 0.3 7

Neutrophil collagenase 7.7 1.0 7 Fibronectin 10.4 0.4 7

Resistin 7.7 0.6 7 Fibulin-1 7.8 0.5 6

Ig kappa chain V-I region Lay 7.7 0.2 7 Ficolin-2 7.3 0.4 3

Proteasome subunit a type 7.7 0.5 7 Ficolin-3 8.3 0.3 7

Elongation factor 2 7.7 1.0 7 Filamin-A 8.7 0.7 7

Fumarylacetoacetase 7.7 0.4 7 Filamin-B 7.2 0.5 5

Glutaredoxin-1 7.7 0.7 7 Flavin reductase (NADPH) 7.9 1.0 7

55 kDa erythrocyte membrane protein 7.7 0.5 7 Flotillin-1 7.0 0.6 4

High mobility group protein B2 7.7 0.8 7 Flotillin-2 7.3 0.5 4

ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 2 7.7 0.4 7 Follistatin-related protein 1 8.1 0.3 7

Puromycin-sensitive aminopeptidase 7.7 0.7 7 Formin-binding protein 1 6.7 0.3 4

UTP--glucose-1-phosphate uridylyltransferase 7.7 0.9 7 Formin-like protein 1 7.0 0.1 2

Tubulin a-1C chain 7.7 0.6 7 Fructose-1,6-bisphosphatase 1 7.7 0.3 6

Ig heavy variable 3/OR15-7 7.7 0.3 7 Fructose-1,6-bisphosphatase isozyme 2 6.8 0.2 2

IgGFc-binding protein 7.6 0.3 7 Fructose-bisphosphate aldolase A 9.2 0.4 7

Retinal dehydrogenase 1 7.6 0.8 7 Fructose-bisphosphate aldolase C 7.7 0.6 6

Phosphoglucomutase-1 7.6 0.7 7 Fumarate hydratase, mitochondrial 6.9 1

Solute carrier family 2, facilitated glucose transporter member 1 7.6 1.2 7 Fumarylacetoacetase 7.7 0.4 7

Extracellular superoxide dismutase [Cu-Zn] 7.6 0.3 7 Galectin-1 7.1 0.4 7

Calreticulin 7.6 0.5 7 Galectin-10 7.6 0.5 7

Non-secretory ribonuclease 7.6 0.6 7 Galectin-3 7.6 0.8 6

Complement C1r subcomponent-like protein 7.6 0.3 7 Galectin-3-binding protein 8.7 0.2 7

Galectin-10 7.6 0.5 7 Gamma-enolase 7.6 0.9 6

Glial fibrillary acidic protein 7.6 1.0 7 Gamma-glutamyl hydrolase 7.6 0.4 7

Adipocyte plasma membrane-associated protein 7.6 0.1 7 Gamma-glutamylcyclotransferase 6.9 0.6 5

Gamma-glutamyl hydrolase 7.6 0.4 7 Gamma-synuclein 5.1 1

6-phosphogluconolactonase 7.5 0.7 7 Ganglioside GM2 activator 6.8 0.4 2

Glutathione synthetase 7.5 0.4 7 Gelsolin 9.8 0.2 7

Stress-induced-phosphoprotein 1 7.5 0.6 7 Glia maturation factor gamma 7.5 0.5 5

Programmed cell death 6-interacting protein 7.5 0.6 7 Glial fibrillary acidic protein 7.6 1.0 7

Adenosine deaminase 7.5 0.5 7 Glucosamine-6-phosphate isomerase 1 7.0 0.5 6

Pregnancy zone protein 7.5 0.5 7 Glucose-6-phosphate 1-dehydrogenase 7.8 0.9 7

Glyoxalase domain-containing protein 4 7.5 0.6 7 Glucose-6-phosphate isomerase 9.0 0.6 7

Thrombospondin-2 7.5 0.4 7 Glucosidase 2 subunit b 7.3 0.7 6

Peptidyl-prolyl cis-trans isomerase B 7.5 0.6 7 Glutamate dehydrogenase 1, mitochondrial 6.9 0.3 4

Actin-related protein 2/3 complex subunit 3 7.5 0.8 7 Glutamate--cysteine ligase catalytic subunit 6.6 1.0 5

Nucleobindin-1 7.5 0.2 7 Glutamine synthetase 7.1 0.6 4

Ig kappa chain V-IV region STH 7.5 0.3 7 Glutaminyl-peptide cyclotransferase 6.5 0.5 5

Peptidase inhibitor 16 7.4 0.4 7 Glutaredoxin-1 7.7 0.7 7

Collagen alpha-2(V) chain 7.4 0.4 7 Glutathione peroxidase 1 7.2 0.7 5

Erythrocyte membrane protein band 4.2 7.4 0.7 7 Glutathione peroxidase 3 8.6 0.2 7

Coagulation factor V 7.4 0.5 7 Glutathione reductase, mitochondrial 7.8 0.6 7

Complement C1q subcomponent subunit A 7.4 0.4 7 Glutathione S-transferase Mu 1/4 6.2 0.9 2

Fatty acid-binding protein, epidermal 7.4 0.5 7 Glutathione S-transferase omega-1 8.1 0.4 7

Adiponectin 7.4 0.2 7 Glutathione S-transferase P 8.5 0.6 7

Proteasome activator complex subunit 2 7.3 0.7 7 Glutathione synthetase 7.5 0.4 7

Lymphocyte-specific protein 1 7.3 0.7 7 Glyceraldehyde-3-phosphate dehydrogenase 9.5 0.5 7

Actin-related protein 2/3 complex subunit 1B 7.3 0.7 7 Glycogen [starch] synthase, muscle 8.0 0.8 5

Xaa-Pro dipeptidase 7.3 0.4 7 Glycogen debranching enzyme 7.5 0.6 2

Macrophage colony-stimulating factor 1 receptor 7.3 0.2 7 Glycogen phosphorylase, liver form 8.1 0.8 7

Endoplasmin 7.3 0.5 7 Glycogenin-1 7.7 0.7 4

Golgi-associated plant pathogenesis-related protein 1 7.3 0.4 7 Glycolipid transfer protein 7.5 0.6 3

Laminin subunit g-1 7.3 0.1 7 Glycophorin-A 7.4 1

Annexin A4 7.3 0.8 7 Glyoxalase domain-containing protein 4 7.5 0.6 7

Ras-related protein Rap-1b 7.3 0.9 7 Golgi membrane protein 1 6.9 1

Cathepsin D 7.3 0.4 7 Golgi-associated plant pathogenesis-related protein 1 7.3 0.4 7

Uncharacterized protein KIAA1328 7.3 0.8 7 Grancalcin 7.7 0.8 7

Myristoylated alanine-rich C-kinase substrate 7.2 0.7 7 Growth factor receptor-bound protein 2 7.6 0.5 5

T-complex protein 1 subunit zeta 7.2 0.2 7 GTP-binding nuclear protein Ran 7.3 0.7 4

Laminin subunit b-1 7.2 0.1 7 Guanine deaminase 7.3 1

Beta-2-microglobulin 7.2 0.4 7 Guanine nucleotide-binding protein G(i) subunit a-2 6.6 0.2 3

Adenylosuccinate lyase 7.2 0.9 7 Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit b-1 7.5 0.2 2

Tubulin alpha-3C/D/E chain 7.2 0.6 7 Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit b-3 7.3 1

Collagen alpha-1(XII) chain 7.2 0.8 7 Guanine nucleotide-binding protein subunit b-4 7.0 0.3 4

Acid ceramidase 7.2 0.3 7 Guanine nucleotide-binding protein subunit g 6.9 0.8 3

1,4-alpha-glucan-branching enzyme 7.1 0.8 7 Haloacid dehalogenase-like hydrolase domain-containing protein 2 7.4 0.1 2

Galectin-1 7.1 0.4 7 Haptoglobin 10.4 0.3 7

Cadherin-13 7.1 0.4 7 Haptoglobin-related protein 10.0 0.3 7

Serpin B6 7.1 0.6 7 Heat shock 70 kDa protein 1A/1B 8.5 0.5 7

Plectin 7.0 0.7 7 Heat shock 70 kDa protein 4 7.0 0.9 5

Proteasome subunit b type-5 7.0 0.6 7 Heat shock 70 kDa protein 6 7.3 0.4 6

Aldehyde dehydrogenase family 16 member A1 6.9 1.1 7 Heat shock cognate 71 kDa protein 7.9 0.7 7

Serine/threonine-protein kinase OSR1 6.9 0.5 7 Heat shock protein 105 kDa 7.2 1

Intercellular adhesion molecule 1 6.7 0.5 7 Heat shock protein HSP 90-a 8.3 0.6 7

Heterogeneous nuclear ribonucleoprotein A1 6.5 1.1 7 Heat shock protein HSP 90-beta 7.7 0.6 6

Ig heavy variable 4-4 8.8 0.6 6 Hematopoietic lineage cell-specific protein 7.6 0.3 4

LisH domain-containing protein ARMC9 8.5 1.0 6 Heme oxygenase 1 7.0 0.9 5

Serum amyloid A-1 protein 8.5 1.7 6 Heme-binding protein 1 6.9 0.4 5

Histone H1.0 8.4 0.3 6 Heme-binding protein 2 7.7 0.6 5

Selenium-binding protein 1 8.4 0.4 6 Hemoglobin subunit a (HBA1) 11.2 0.5 7

Delta-aminolevulinic acid dehydratase 8.4 0.5 6 Hemoglobin subunit alpha (HBA2) 8.4 0.6 7

Eosinophil cationic protein 8.3 0.6 6 Hemoglobin subunit b 11.4 0.4 7

Protein FAM49B 8.2 0.8 6 Hemoglobin subunit delta 9.9 0.6 7

Peroxiredoxin-1 8.2 0.5 6 Hemoglobin subunit gamma-2 7.8 0.5 5

Proteasome subunit alpha type-2 8.1 0.5 6 Hemoglobin subunit gamma-1 8.7 0.8 7

Cullin-associated NEDD8-dissociated protein 1 8.1 0.8 6 Hemoglobin subunit mu 7.2 0.3 5

Peroxiredoxin-5, mitochondrial 8.1 0.7 6 Hemoglobin subunit theta-1 6.9 0.4 3

Ig kappa chain V-III region IARC/BL41 8.1 0.4 6 Hemopexin 10.1 0.2 7

F-actin-capping protein subunit a-1 8.0 0.9 6 Heparin cofactor 2 9.4 0.3 7

Low affinity immunoglobulin gamma Fc region receptor III-A 8.0 0.5 6 Hepatocyte growth factor-like protein 7.6 0.1 5

Ig kappa chain V-II region FR 8.0 0.4 6 Hepatoma-derived growth factor 7.6 0.4 5

Ig lambda variable 2-18 8.0 0.2 6 Hepatoma-derived growth factor-related protein 2 6.7 1

Platelet-activating factor acetylhydrolase IB subunit b 8.0 0.3 6 Heterochromatin protein 1-binding protein 3 6.7 0.4 2

Spectrin beta chain, non-erythrocytic 1 8.0 0.9 6 Heterogeneous nuclear ribonucleoprotein A1 6.5 1.1 7

Myosin regulatory light chain 12A 8.0 0.5 6 Heterogeneous nuclear ribonucleoprotein D0 7.7 0.6 6

Transgelin-2 8.0 0.6 6 Heterogeneous nuclear ribonucleoprotein K 7.3 0.5 4

Ig kappa chain V-I region Mev 8.0 0.1 6 Heterogeneous nuclear ribonucleoproteins A2/B1 7.2 0.3 5

Protein DJ-1 8.0 0.5 6 Heterogeneous nuclear ribonucleoproteins C1/C2 7.2 0.4 4

Thymidine phosphorylase 8.0 0.6 6 Hexokinase-3 7.6 1.8 5

Leucine-rich repeat-containing protein 10B 7.9 0.5 6 High affinity choline transporter 1 7.1 0.1 2

Aspartate aminotransferase, cytoplasmic 7.9 0.7 6 High affinity immunoglobulin epsilon receptor subunit g 6.0 1

Macrophage migration inhibitory factor 7.9 0.3 6 High mobility group protein B1 7.5 0.6 5

Phosphatidylethanolamine-binding protein 1 7.9 0.6 6 High mobility group protein B2 7.7 0.8 7

Ig lambda chain V-II region TRO 7.9 0.2 6 High mobility group protein HMG-I/HMG-Y 6.2 0.1 2

Proteasome subunit beta type-1 7.8 0.9 6 Hippocalcin-like protein 1 7.3 0.5 6

Fibulin-1 7.8 0.5 6 Histidine-rich glycoprotein 9.8 0.2 7

Adenosylhomocysteinase 7.8 0.5 6 Histidine--tRNA ligase, cytoplasmic 6.9 0.4 3

Ras-related protein Rab-11 7.8 0.6 6 Histone H1.0 8.4 0.3 6

Immunoglobulin lambda variable 1-40 7.8 0.4 6 Histone H1.2 7.5 0.5 4

Rho GDP-dissociation inhibitor 1 7.8 0.6 6 Histone H1.3 7.5 0.2 3

Apolipoprotein B receptor 7.8 0.6 6 Histone H1.4 8.2 0.4 7

Integrin a-M 7.8 0.8 6 Histone H1.5 8.0 0.7 7

Aflatoxin B1 aldehyde reductase member 2 7.8 0.2 6 Histone H1x 7.3 0.3 4

14-3-3 protein gamma 7.8 0.6 6 Histone H2A 8.2 0.5 4

Cadherin-5 7.7 0.2 6 Histone H2A type 1-J 9.4 0.8 7

Ig kappa chain V-I region AU 7.7 0.4 6 Histone H2A type 2-B 7.8 0.7 5

Synaptic vesicle membrane protein VAT-1 homolog 7.7 0.6 6 Histone H2B 9.6 0.8 7

Ig heavy chain V-III region WEA 7.7 0.4 6 Histone H3 8.8 0.9 7

Proteasome subunit a type-3 7.7 0.5 6 Histone H4 9.3 0.9 7

Fructose-1,6-bisphosphatase 1 7.7 0.3 6 HLA class I histocompatibility antigen, Cw-4 a chain 8.0 0.7 5

Annexin A6 7.7 1.1 6 Hsc70-interacting protein 7.7 0.3 3

Target of Nesh-SH3 7.7 0.5 6 Hsp90 co-chaperone Cdc37 7.1 0.7 3

Heterogeneous nuclear ribonucleoprotein D0 7.7 0.6 6 Hyaluronan and proteoglycan link protein 2 7.4 0.5 6

Heat shock protein HSP 90-beta 7.7 0.6 6 Hyaluronan-binding protein 2 7.8 0.3 7

Ubiquitin-conjugating enzyme E2 L3 7.7 1.0 6 Hydroxyacylglutathione hydrolase, mitochondrial 6.3 1

Procollagen C-endopeptidase enhancer 1 7.7 0.2 6 Hypoxanthine-guanine phosphoribosyltransferase 8.0 0.5 7

Fructose-bisphosphate aldolase C 7.7 0.6 6 Hypoxia up-regulated protein 1 6.4 0.4 3

Tumor protein D54 7.6 0.4 6 ICOS ligand 7.3 0.4 6

Protein kinase C and casein kinase substrate in neurons protein 2 7.6 0.3 6 Ig alpha-1 chain C region 10.8 0.2 7

Collagen alpha-1(V) chain 7.6 0.5 6 Ig alpha-2 chain C region 8.8 0.4 7

Gamma-enolase 7.6 0.9 6 Ig delta chain C region 8.0 0.7 7

ADP-ribosylation factor 1/3 7.6 0.5 6 Ig gamma-1 chain C region 10.9 0.2 7

Neprilysin 7.6 0.4 6 Ig gamma-2 chain C region 10.2 0.2 7

Ig heavy chain V-III region JON 7.6 0.7 6 Ig gamma-3 chain C region 9.5 0.1 7

Ezrin 7.6 0.5 6 Ig gamma-4 chain C region 9.2 0.5 7

Galectin-3 7.6 0.8 6 Ig heavy chain V-I region EU 7.2 0.2 5

Vitamin K-dependent protein Z 7.6 0.5 6 Ig heavy chain V-I region HG3 7.5 0.2 5

Annexin A11 7.5 0.7 6 Ig heavy chain V-I region V35 8.8 0.4 7

Ig kappa chain V-I region Kue 7.5 0.4 6 Ig heavy chain V-II region ARH-77 8.3 0.6 7

Calpain small subunit 1 7.5 0.5 6 Ig heavy chain V-II region WAH 8.0 0.2 7

Importin subunit b-1 7.5 1.1 6 Ig heavy chain V-III region BRO 9.5 0.3 7

Sodium/potassium-transporting ATPase subunit a-1 7.5 0.5 6 Ig heavy chain V-III region BUT 8.1 0.3 7

Phospholipase B-like 1 7.5 1.1 6 Ig heavy chain V-III region GAL 8.5 0.3 7

Multifunctional protein ADE2 7.5 0.3 6 Ig heavy chain V-III region GAR 7.4 0.4 5

Proteasome subunit b type-6 7.5 0.6 6 Ig heavy chain V-III region JON 7.6 0.7 6

Translin 7.5 1.0 6 Ig heavy chain V-III region KOL 8.9 0.2 7

Cell division control protein 42 homolog 7.5 0.9 6 Ig heavy chain V-III region LAY 7.8 0.6 7

Osteoclast-stimulating factor 1 7.5 0.7 6 Ig heavy chain V-III region TIL 9.3 0.3 7

Immunoglobulin heavy variable 3-64 7.4 0.2 6 Ig heavy chain V-III region WEA 7.7 0.4 6

Prosaposin 7.4 0.4 6 Ig heavy chain V-III region ZAP 6.9 0.1 3

Immunoglobulin lambda variable 3-27 7.4 0.3 6 Ig kappa chain V-I region AU 7.7 0.4 6

Coagulation factor XIII B chain 7.4 0.2 6 Ig kappa chain V-I region BAN 8.3 0.2 7

Insulin-like growth factor-binding protein 3 7.4 0.4 6 Ig kappa chain V-I region CAR 6.5 0.5 4

Integrin b-2 7.4 0.6 6 Ig kappa chain V-I region DEE 8.2 0.4 7

Protein disulfide-isomerase A6 7.4 0.5 6 Ig kappa chain V-I region EU 9.1 0.4 7

Hyaluronan and proteoglycan link protein 2 7.4 0.5 6 Ig kappa chain V-I region HK101 7.4 0.5 3

Tyrosine-protein phosphatase non-receptor type substrate 1 7.3 0.6 6 Ig kappa chain V-I region HK102 7.6 0.2 4

T-complex protein 1 subunit b 7.3 0.4 6 Ig kappa chain V-I region Kue 7.5 0.4 6

Dipeptidyl peptidase 3 7.3 0.6 6 Ig kappa chain V-I region Lay 7.7 0.2 7

Heat shock 70 kDa protein 6 7.3 0.4 6 Ig kappa chain V-I region Mev 8.0 0.1 6

Hippocalcin-like protein 1 7.3 0.5 6 Ig kappa chain V-I region Ni 8.9 0.3 7

Endoplasmic reticulum resident protein 29 7.3 0.6 6 Ig kappa chain V-I region Roy 8.6 0.4 7

ICOS ligand 7.3 0.4 6 Ig kappa chain V-I region WEA 9.6 0.2 7

Glucosidase 2 subunit b 7.3 0.7 6 Ig kappa chain V-I region Wes 8.6 0.2 7

Ubiquitin-like modifier-activating enzyme 1 7.3 0.7 6 Ig kappa chain V-II region FR 8.0 0.4 6

Mitogen-activated protein kinase 1 7.3 0.4 6 Ig kappa chain V-II region GM607 9.6 0.2 7

Transferrin receptor protein 1, serum form 7.2 0.2 6 Ig kappa chain V-II region RPMI 6410 6.7 1

Myeloid cell nuclear differentiation antigen 7.2 0.8 6 Ig kappa chain V-III region B6 8.5 0.4 7

14-3-3 protein sigma 7.2 0.3 6 Ig kappa chain V-III region CLL 8.4 0.5 7

14-3-3 protein eta 7.2 0.9 6 Ig kappa chain V-III region IARC/BL41 8.1 0.4 6

Transforming protein RhoA/B/C 7.2 0.7 6 Ig kappa chain V-III region NG9 9.3 0.2 7

Nucleophosmin 7.2 1.1 6 Ig kappa chain V-III region POM 7.9 0.3 7

Pyruvate kinase (PKM2) 7.2 0.5 6 Ig kappa chain V-III region SIE 10.2 0.2 7

Serine/threonine-protein phosphatase 2A activator 7.2 0.7 6 Ig kappa chain V-III region VG 8.9 0.5 7

NAD kinase 7.2 0.4 6 Ig kappa chain V-IV region Len 9.7 0.3 7

Inositol monophosphatase 1 7.2 0.6 6 Ig kappa chain V-IV region STH 7.5 0.3 7

Cholesteryl ester transfer protein 7.2 0.5 6 Ig lambda chain V region 4A 8.2 0.4 7

Multiple inositol polyphosphate phosphatase 1 7.1 0.3 6 Ig lambda chain V-I region NEW 8.0 0.5 7

Pantetheinase 7.1 0.3 6 Ig lambda chain V-I region NIG-64 8.1 0.1 7

Putative GTP cyclohydrolase 1 type 2 NIF3L1 7.1 0.7 6 Ig lambda chain V-I region VOR 8.3 0.3 7

Proteasome subunit b type-4 7.1 0.5 6 Ig lambda chain V-I region WAH 9.3 0.3 7

Cytochrome c 7.1 0.9 6 Ig lambda chain V-II region BUR 8.1 0.5 7

14-3-3 protein theta 7.1 0.6 6 Ig lambda chain V-II region NIG-84 8.3 0.3 7

ATP-citrate synthase 7.1 0.6 6 Ig lambda chain V-II region TRO 7.9 0.2 6

Matrix-remodeling-associated protein 5 7.1 0.5 6 Ig lambda chain V-III region LOI 9.0 0.4 7

Immunoglobulin superfamily containing leucine-rich repeat protein 7.0 0.7 6 Ig lambda chain V-III region SH 8.9 0.2 7

Glucosamine-6-phosphate isomerase 1 7.0 0.5 6 Ig lambda chain V-IV region Hil 9.0 0.3 7

Neutrophil cytosol factor 2 7.0 0.4 6 Ig lambda chain V-V region DEL 7.8 0.4 7

Proteasome subunit b type 7.0 0.7 6 Ig lambda chain V-VI region AR 7.9 0.2 5

Protein-L-isoaspartate O-methyltransferase 7.0 0.6 6 Ig lambda chain V-VI region WLT 7.6 0.3 4

SPARC-like protein 1 7.0 0.6 6 Ig lambda-1 chain C regions 10.5 0.2 7

Ribonuclease T2 6.9 1.1 6 Ig lambda-2 chain C regions 9.9 0.3 7

COP9 signalosome complex subunit 5 6.9 0.6 6 Ig mu chain C region 10.2 0.3 7

Intersectin-2 6.9 0.3 6 IgGFc-binding protein 7.6 0.3 7

Prelamin-A/C 6.9 0.8 6 Ig heavy variable 3/OR15-7 7.7 0.3 7

Superoxide dismutase [Cu-Zn] 6.9 1.3 6 Ig heavy variable 3/OR16-13 9.0 0.3 7

4F2 cell-surface antigen heavy chain 6.8 0.5 6 Ig heavy variable 3-64 7.4 0.2 6

Alpha-synuclein 6.8 0.7 6 Ig heavy variable 4-4 8.8 0.6 6

Beta-hexosaminidase subunit b 6.8 0.5 6 Ig J chain 8.7 0.3 7

BH3-interacting domain death agonist 6.8 0.9 6 Ig lambda variable 1-40 7.8 0.4 6

Proteasome subunit b type-7 6.7 0.7 6 Ig lambda variable 16-47 8.2 0.1 7

Cytosolic non-specific dipeptidase 6.7 0.5 6 Ig lambda variable 2-14 8.1 0.7 7

Smoothelin-like protein 2 8.3 0.6 5 Ig lambda variable 2-18 8.0 0.2 6

Chitotriosidase-1 8.2 0.8 5 Ig lambda variable 3-1 7.3 0.4 4

Cystatin-A 8.1 1.0 5 Ig lambda variable 3-10 8.1 0.3 7

Glycogen [starch] synthase, muscle 8.0 0.8 5 Ig lambda variable 3-19 7.4 0.1 4

Ankyrin-1 8.0 1.2 5 Ig lambda variable 3-21 9.3 0.2 7

HLA class I histocompatibility antigen, Cw-4 a chain 8.0 0.7 5 Ig lambda variable 3-27 7.4 0.3 6

Major vault protein 8.0 1.1 5 Ig lambda variable 3-9 8.0 0.3 7

Actin-related protein 2/3 complex subunit 5 8.0 0.6 5 Ig lambda variable 6-57 8.4 0.3 7

Annexin A5 7.9 1.5 5 Ig lambda variable 8-61 8.3 0.4 7

Ubiquitin-conjugating enzyme E2 variant 1 7.9 1.0 5 Ig lambda-like polypeptide 1 8.1 0.4 7

Ig lambda chain V-VI region AR 7.9 0.2 5 Ig superfamily containing leucine-rich repeat protein 7.0 0.7 6

Hemoglobin subunit g-2 7.8 0.5 5 Importin subunit b-1 7.5 1.1 6

Phosphoglucomutase-2 7.8 0.8 5 Importin-5 7.0 0.3 2

Histone H2A type 2-B 7.8 0.7 5 Importin-9 6.2 0.3 2

Acylamino-acid-releasing enzyme 7.8 0.7 5 Ig lambda variable 3-25 8.4 0.4 7

Protein SET 7.7 0.9 5 Inositol monophosphatase 1 7.2 0.6 6

Vasodilator-stimulated phosphoprotein 7.7 0.6 5 Inositol monophosphatase 2 6.7 0.4 5

Heme-binding protein 2 7.7 0.6 5 Insulin-like growth factor-binding protein 3 7.4 0.4 6

Transcription factor 20 7.7 0.4 5 Insulin-like growth factor-binding protein 7 7.2 0.2 5

Ribonuclease inhibitor 7.7 0.5 5 Insulin-like growth factor-binding protein complex acid labile subunit 8.9 0.4 7

S-phase kinase-associated protein 1 7.7 0.4 5 Integral membrane protein 2B 6.0 0.8 3

Acidic leucine-rich nuclear phosphoprotein 32 family member A 7.7 0.6 5 Integrin a-M 7.8 0.8 6

Protein CutA 7.7 0.5 5 Integrin b-2 7.4 0.6 6

Mannose-binding protein C 7.7 0.3 5 Integrin beta-1 6.9 0.2 4

Blood group Rh(D/C/E) polypeptide 7.7 0.3 5 Inter-alpha-trypsin inhibitor heavy chain H1 9.7 0.3 7

Proteasome subunit beta type-3 7.6 0.6 5 Inter-alpha-trypsin inhibitor heavy chain H2 9.8 0.2 7

Costars family protein ABRACL 7.6 0.8 5 Inter-alpha-trypsin inhibitor heavy chain H3 8.9 0.4 7

Ras-related C3 botulinum toxin substrate 2 7.6 0.5 5 Inter-alpha-trypsin-inhibitor heavy chain H4 10.1 0.3 7

Hepatocyte growth factor-like protein 7.6 0.1 5 Intercellular adhesion molecule 1 6.7 0.5 7

Hexokinase-3 7.6 1.8 5 Interferon-induced 35 kDa protein 7.3 0.5 4

Perilipin-3 7.6 0.6 5 Interferon-induced guanylate-binding protein 1/2 7.3 0.2 2

V-type proton ATPase catalytic subunit A 7.6 0.5 5 Interleukin enhancer-binding factor 2 7.3 0.4 4

Coagulation factor X 7.6 0.4 5 Interleukin enhancer-binding factor 3 7.3 0.5 4

Hepatoma-derived growth factor 7.6 0.4 5 Intersectin-2 6.9 0.3 6

Ubiquitin thioesterase OTUB1 7.6 0.2 5 Interstitial collagenase 7.1 0.5 4

Growth factor receptor-bound protein 2 7.6 0.5 5 Isoamyl acetate-hydrolyzing esterase 1 homolog 6.8 0.3 3

Protein-arginine deiminase type-4 7.6 0.6 5 Isoaspartyl peptidase/L-asparaginase 7.1 1

Olfactomedin-4 7.5 0.9 5 Isocitrate dehydrogenase [NADP] cytoplasmic 7.7 0.6 7

High mobility group protein B1 7.5 0.6 5 Isocitrate dehydrogenase [NADP], mitochondrial 6.8 0.1 2

Annexin A2 7.5 0.5 5 Kallistatin 8.7 0.3 7

BTB/POZ domain-containing protein KCTD12 7.5 0.4 5 Kell blood group glycoprotein 7.2 0.2 4

Calcium-binding protein 39 7.5 0.6 5 Ketosamine-3-kinase 7.0 0.1 2

Programmed cell death protein 6 7.5 0.5 5 Kinesin-1 heavy chain 5.9 1

Aspartate aminotransferase, mitochondrial 7.5 0.6 5 Lactotransferrin 9.6 0.8 7

Small ubiquitin-related modifier 2/3/4 7.5 0.3 5 Lamin-B receptor 6.5 0.2 2

Copine-3 7.5 0.3 5 Lamin-B1 8.0 0.7 7

Clathrin heavy chain 1 7.5 0.6 5 Lamin-B2 7.3 0.3 5

Adenylosuccinate synthetase isozyme 2 7.5 0.8 5 Laminin subunit alpha-4 7.1 0.6 5

Bridging integrator 2 7.5 0.8 5 Laminin subunit alpha-5 7.1 0.1 3

Glia maturation factor gamma 7.5 0.5 5 Laminin subunit b-1 7.2 0.1 7

Ig heavy chain V-I region HG3 7.5 0.2 5 Laminin subunit g-1 7.3 0.1 7 cAMP-dependent protein kinase type I-a regulatory subunit 7.4 0.7 5 Latexin 7.1 0.1 2

Elongation factor 1-g 7.4 0.5 5 Leucine-rich alpha-2-glycoprotein 9.7 0.4 7

Ig heavy chain V-III region GAR 7.4 0.4 5 Leucine-rich repeat flightless-interacting protein 1 7.2 0.7 5

Exportin-2 7.4 1.5 5 Leucine-rich repeat-containing protein 10B 7.9 0.5 6

UV excision repair protein RAD23 homolog B 7.4 0.4 5 Leukocyte elastase inhibitor 8.7 0.5 7

Scavenger receptor cysteine-rich type 1 protein M130/Soluble CD163 7.4 0.2 5 Leukocyte immunoglobulin-like receptor subfamily A member 1/2/3/4/6 7.3 0.4 4 Peptidoglycan recognition protein 1 7.4 0.8 5 Leukocyte surface antigen CD47 6.8 0.6 4

Tubulin-specific chaperone A 7.4 0.4 5 Leukotriene A-4 hydrolase 8.9 0.5 7

Bleomycin hydrolase 7.3 0.6 5 LIM and SH3 domain protein 1 7.5 0.2 3

Syntenin-1 7.3 1.4 5 Lipopolysaccharide-binding protein 8.9 0.5 7

Lamin-B2 7.3 0.3 5 LisH domain-containing protein ARMC9 8.5 1.0 6

Receptor-type tyrosine-protein phosphatase C 7.3 0.6 5 Liver carboxylesterase 1 7.3 0.1 3

Carcinoembryonic antigen-related cell adhesion molecule 6 7.3 0.7 5 L-lactate dehydrogenase A chain 9.1 0.5 7

Platelet basic protein 7.3 0.7 5 L-lactate dehydrogenase B chain 8.7 0.4 7

Tyrosine-protein phosphatase non-receptor type 6 7.3 0.5 5 Low affinity immunoglobulin gamma Fc region receptor III-A 8.0 0.5 6

Tripeptidyl-peptidase 2 7.2 0.5 5 Low affinity immunoglobulin gamma Fc region receptor III-B 8.1 0.6 3

Tubulin beta chain 7.2 0.3 5 Low molecular weight phosphotyrosine protein phosphatase 7.2 1

Leucine-rich repeat flightless-interacting protein 1 7.2 0.7 5 Lumican 9.2 0.2 7

Thioredoxin reductase 1, cytoplasmic 7.2 0.7 5 Lymphocyte-specific protein 1 7.3 0.7 7

NSFL1 cofactor p47 7.2 0.3 5 Lysosomal alpha-mannosidase 6.7 0.4 2

Heterogeneous nuclear ribonucleoproteins A2/B1 7.2 0.3 5 Lysosome-associated membrane glycoprotein 1 6.9 0.6 3

Allograft inflammatory factor 1 7.2 0.5 5 Lysosome-associated membrane glycoprotein 2 8.2 0.4 7

Filamin-B 7.2 0.5 5 Lysozyme C 8.3 0.4 7

Malate dehydrogenase, mitochondrial 7.2 0.4 5 Macrophage colony-stimulating factor 1 receptor 7.3 0.2 7

Insulin-like growth factor-binding protein 7 7.2 0.2 5 Macrophage migration inhibitory factor 7.9 0.3 6

Elongation factor 1-d 7.2 0.8 5 Macrophage-capping protein 8.2 0.6 7

X-ray repair cross-complementing protein 6 7.2 0.3 5 Major prion protein 7.8 1

Ig heavy chain V-I region EU 7.2 0.2 5 Major vault protein 8.0 1.1 5

72 kDa type IV collagenase 7.2 0.5 5 Malate dehydrogenase, cytoplasmic 8.2 0.7 7

Glutathione peroxidase 1 7.2 0.7 5 Malate dehydrogenase, mitochondrial 7.2 0.4 5

Hemoglobin subunit mu 7.2 0.3 5 Maltase-glucoamylase, intestinal 7.5 0.6 4

Dynactin subunit 1 7.2 0.8 5 Mannose-binding protein C 7.7 0.3 5

Protein 4.1 7.2 0.3 5 MAP7 domain-containing protein 1 5.3 1

Laminin subunit alpha-4 7.1 0.6 5 MARCKS-related protein 6.8 0.7 5

Calpastatin 7.1 0.6 5 Matrix metalloproteinase-9 8.5 1.1 7

V-type proton ATPase subunit B, brain isoform 7.1 0.5 5 Matrix-remodeling-associated protein 5 7.1 0.5 6

N-acetyl-D-glucosamine kinase 7.1 0.2 5 Metalloproteinase inhibitor 1 8.2 0.3 7

Tropomyosin alpha-1 chain 7.1 0.5 5 Microtubule-associated protein 1B 7.0 1

Protein diaphanous homolog 1 7.1 0.8 5 Mini-chromosome maintenance complex-binding protein 7.1 1

Eukaryotic translation initiation factor 5A-1 7.0 0.4 5 Mitochondrial 2-oxoglutarate/malate carrier protein 6.9 1

CapZ-interacting protein 7.0 0.6 5 Mitochondrial fission 1 protein 6.7 0.9 3

Heat shock 70 kDa protein 4 7.0 0.9 5 Mitochondrial peptide methionine sulfoxide reductase 6.9 0.4 2

Unconventional myosin-Ie/f 7.0 0.4 5 Mitogen-activated protein kinase 1 7.3 0.4 6

PML-RARA-regulated adapter molecule 1 7.0 0.3 5 MOB kinase activator 1A/B 6.8 0.2 3

AP-1 complex subunit beta-1 7.0 0.6 5 Moesin 9.0 0.5 7

AMP deaminase 3 7.0 0.7 5 Monocyte differentiation antigen CD14 8.9 0.2 7

Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit Aa 7.0 0.7 5 Multifunctional protein ADE2 7.5 0.3 6

Sorcin 7.0 0.5 5 Multiple inositol polyphosphate phosphatase 1 7.1 0.3 6

Heme oxygenase 1 7.0 0.9 5 Myc box-dependent-interacting protein 1 7.3 1

Arachidonate 5-lipoxygenase 7.0 0.4 5 Myelin basic protein 6.9 1.3 2

Quinone oxidoreductase PIG3 7.0 0.6 5 Myelin P2 protein 6.8 1

Ubiquitin carboxyl-terminal hydrolase 7.0 0.3 5 Myelin proteolipid protein 7.2 0.8 3

Alpha-hemoglobin-stabilizing protein 6.9 0.8 5 Myeloblastin 8.7 0.6 7

Ras suppressor protein 1 6.9 0.5 5 Myeloid cell nuclear differentiation antigen 7.2 0.8 6

Gamma-glutamylcyclotransferase 6.9 0.6 5 Myeloperoxidase 9.6 0.7 7

Twinfilin-2 6.9 0.7 5 Myosin light chain 4 7.5 1

Splicing factor U2AF 65 kDa subunit 6.9 0.6 5 Myosin light polypeptide 6 8.3 0.7 7

Ras-related protein Rab-1A 6.9 0.6 5 Myosin regulatory light chain 12A 8.0 0.5 6

F-actin-capping protein subunit a-2 6.9 1.0 5 Myosin-9 9.1 0.8 7

Cathepsin L1 6.9 0.4 5 Myotrophin 7.6 0.6 4

Ubiquitin carboxyl-terminal hydrolase 5 6.9 0.5 5 Myristoylated alanine-rich C-kinase substrate 7.2 0.7 7

Heme-binding protein 1 6.9 0.4 5 N(4)-(beta-N-acetylglucosaminyl)-L-asparaginase 6.5 1

Proliferation-associated protein 2G4 6.8 0.7 5 N(G),N(G)-dimethylarginine dimethylaminohydrolase 1 6.8 1.0 2

MARCKS-related protein 6.8 0.7 5 Na+/H+ exchange regulatory cofactor NHE-RF1 7.6 0.5 4

WW domain-binding protein 2 6.8 0.4 5 N-acetyl-D-glucosamine kinase 7.1 0.2 5

Porphobilinogen deaminase 6.7 1.3 5 N-acetylgalactosamine-6-sulfatase 7.4 0.2 3

Epidermal growth factor receptor substrate 15 6.7 0.4 5 N-acetylglucosamine-6-sulfatase 6.6 0.7 3

Inositol monophosphatase 2 6.7 0.4 5 N-acetylmuramoyl-L-alanine amidase 8.2 0.8 7

Nucleosome assembly protein 1-like 4 6.7 0.8 5 NAD kinase 7.2 0.4 6

Ribosyldihydronicotinamide dehydrogenase [quinone] 6.7 0.7 5 NAD(P)H-hydrate epimerase 7.3 1

Creatine kinase B-type 6.6 0.3 5 NAD-dependent protein deacetylase sirtuin-2 7.1 1

Glutamate--cysteine ligase catalytic subunit 6.6 1.0 5 NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial 6.9 1

Ribose-phosphate pyrophosphokinase 1 6.6 0.8 5 NADH-cytochrome b5 reductase 3 6.8 0.5 3

Calnexin 6.6 0.2 5 NADP-dependent malic enzyme 5.9 1

Thioredoxin-like protein 1 6.5 0.4 5 Nascent polypeptide-associated complex subunit a 7.3 0.2 2

Glutaminyl-peptide cyclotransferase 6.5 0.5 5 Nck-associated protein 1-like 6.9 1

Di-N-acetylchitobiase 6.5 0.3 5 NEDD8 7.5 1

Drebrin-like protein 6.4 0.8 5 Neprilysin 7.6 0.4 6

Prohibitin-2 6.2 0.3 5 Neural cell adhesion molecule 1 6.9 0.3 4

Phosphoribosyl pyrophosphate synthase-associated protein 2 6.0 0.3 5 Neurofilament light polypeptide 7.7 0.7 3

Arginase-1 8.4 0.3 4 Neurofilament medium polypeptide 8.0 1

Core histone macro-H2A.1 8.3 0.9 4 Neuromodulin 6.4 0.5 2

Histone H2A 8.2 0.5 4 Neutral alpha-glucosidase AB 7.3 1

Retinoblastoma-like protein 1 8.0 0.7 4 Neutrophil collagenase 7.7 1.0 7

Protein-arginine deiminase type-2 8.0 0.4 4 Neutrophil cytosol factor 1 7.6 0.3 4

Rab GDP dissociation inhibitor a 7.9 0.7 4 Neutrophil cytosol factor 2 7.0 0.4 6

Calponin-2 7.9 0.4 4 Neutrophil cytosol factor 4 9.0 0.8 7

Proteasome subunit b type-8 7.8 0.4 4 Neutrophil elastase 7.8 1.0 7

Adenylate kinase 2, mitochondrial 7.7 0.5 4 Neutrophil gelatinase-associated lipocalin 8.9 0.5 7

Glycogenin-1 7.7 0.7 4 N-formyl peptide receptor 2 6.4 1

Ig lambda chain V-VI region WLT 7.6 0.3 4 Nicastrin 5.9 1

Neutrophil cytosol factor 1 7.6 0.3 4 Nicotinamide mononucleotide adenylyltransferase 1 7.7 1

Na+/H+ exchange regulatory cofactor NHE-RF1 7.6 0.5 4 Nicotinamide phosphoribosyltransferase 8.5 0.8 7

Ras-related protein Rab-7a 7.6 0.6 4 Nicotinate phosphoribosyltransferase 7.3 0.8 4

DNA-(apurinic or apyrimidinic site) lyase 7.6 0.7 4 Nitric oxide synthase, inducible 6.5 1

Myotrophin 7.6 0.6 4 N-myc-interactor 6.9 0.2 3

Hematopoietic lineage cell-specific protein 7.6 0.3 4 Non-histone chromosomal protein HMG-14 5.9 0.4 2

Ig kappa chain V-I region HK102 7.6 0.2 4 Non-secretory ribonuclease 7.6 0.6 7

Aminopeptidase B 7.6 0.4 4 NSFL1 cofactor p47 7.2 0.3 5

Argininosuccinate lyase 7.5 0.4 4 Nuclear mitotic apparatus protein 1 6.2 1.5 3

Acyl-CoA-binding protein 7.5 0.7 4 Nuclear pore membrane glycoprotein 210 6.9 0.4 3

Ribose-5-phosphate isomerase 7.5 0.3 4 Nuclear transport factor 2 7.7 1.3 2

Maltase-glucoamylase, intestinal 7.5 0.6 4 Nuclear ubiquitous casein and cyclin-dependent kinase substrate 1 6.5 0.2 2

Histone H1.2 7.5 0.5 4 Nucleobindin-1 7.5 0.2 7

Chromogranin-A 7.5 0.7 4 Nucleolin 7.0 0.3 4

Vascular non-inflammatory molecule 2 7.5 0.4 4 Nucleophosmin 7.2 1.1 6

Cytosolic purine 5-nucleotidase 7.5 0.6 4 Nucleoprotein TPR 7.1 0.3 3

Elongation factor 1-a 1/2 7.4 0.3 4 Nucleoside diphosphate kinase 8.0 0.6 7

Thioredoxin-dependent peroxide reductase, mitochondrial 7.4 0.6 4 Nucleosome assembly protein 1-like 4 6.7 0.8 5

Protein XRP2 7.4 0.4 4 Obg-like ATPase 1 6.6 0.6 4

Ubiquitin-conjugating enzyme E2 K 7.4 0.7 4 Olfactomedin-4 7.5 0.9 5

Proteasome subunit b type-10 7.4 0.9 4 Olfactory receptor 51J1 7.9 0.7 3

Ig lambda variable 3-19 7.4 0.1 4 Osteoclast-stimulating factor 1 7.5 0.7 6

Farnesyl pyrophosphate synthase 7.4 0.6 4 Osteopontin 8.4 0.4 7

Nicotinate phosphoribosyltransferase 7.3 0.8 4 Pantetheinase 7.1 0.3 6

Leukocyte immunoglobulin-like receptor subfamily A member 1/2/3/4/6 7.3 0.4 4 Pentraxin-related protein PTX3 8.6 0.5 7

GTP-binding nuclear protein Ran 7.3 0.7 4 Peptidase inhibitor 16 7.4 0.4 7

Ig lambda variable 3-1 7.3 0.4 4 Peptidoglycan recognition protein 1 7.4 0.8 5

Heterogeneous nuclear ribonucleoprotein K 7.3 0.5 4 Peptidyl-prolyl cis-trans isomerase A 8.6 0.4 7

Histone H1x 7.3 0.3 4 Peptidyl-prolyl cis-trans isomerase B 7.5 0.6 7

Interleukin enhancer-binding factor 3 7.3 0.5 4 Peptidyl-prolyl cis-trans isomerase FKBP1A 7.9 0.8 7

Flotillin-2 7.3 0.5 4 Perilipin-3 7.6 0.6 5

Interferon-induced 35 kDa protein 7.3 0.5 4 Peroxiredoxin-1 8.2 0.5 6

Interleukin enhancer-binding factor 2 7.3 0.4 4 Peroxiredoxin-2 9.8 0.7 7

Aspartyl aminopeptidase 7.2 0.5 4 Peroxiredoxin-5, mitochondrial 8.1 0.7 6

Thioredoxin domain-containing protein 17 7.2 0.5 4 Peroxiredoxin-6 8.7 0.6 7

Polyadenylate-binding protein 1/3 7.2 0.6 4 Peroxisomal acyl-coenzyme A oxidase 1 7.2 0.4 2

Prenylcysteine oxidase 1 7.2 0.3 4 PEST proteolytic signal-containing nuclear protein 5.5 1

Ectonucleotide pyrophosphatase/phosphodiesterase family member 2 7.2 0.4 4 Phosphatidylcholine-sterol acyltransferase 8.1 0.1 7

Cathepsin S 7.2 0.3 4 Phosphatidylethanolamine-binding protein 1 7.9 0.6 6

Beta-glucuronidase 7.2 0.6 4 Phosphatidylinositol 5-phosphate 4-kinase type-2 a/b 6.8 1

60S acidic ribosomal protein P1 7.2 0.4 4 Phosphatidylinositol transfer protein a isoform 6.7 0.3 4

Heterogeneous nuclear ribonucleoproteins C1/C2 7.2 0.4 4 Phosphatidylinositol transfer protein b isoform 6.5 1

Kell blood group glycoprotein 7.2 0.2 4 Phosphatidylinositol-binding clathrin assembly protein 6.6 1

Protein phosphatase 1A/B 7.2 0.5 4 Phosphatidylinositol-glycan-specific phospholipase D 8.3 0.4 7

Transcobalamin-1 7.1 0.6 4 Phosphoglucomutase-1 7.6 0.7 7

ERO1-like protein a 7.1 0.6 4 Phosphoglucomutase-2 7.8 0.8 5

Acidic leucine-rich nuclear phosphoprotein 32 family member B 7.1 1.1 4 Phosphoglycerate kinase 1 8.9 0.5 7

CD63 antigen 7.1 0.3 4 Phosphoglycerate mutase 1 8.5 0.5 7

Glutamine synthetase 7.1 0.6 4 Phospholipase B-like 1 7.5 1.1 6

Serine/arginine-rich splicing factor 3 7.1 0.4 4 Phospholipid scramblase 1 7.3 1

Cystatin-B 7.1 0.7 4 Phospholipid transfer protein 9.3 0.3 7

T-complex protein 1 subunit theta 7.1 0.6 4 Phospholysine phosphohistidine inorganic pyrophosphate phosphatase 7.2 1

Vacuolar protein sorting-associated protein 35 7.1 0.5 4 Phosphoribosyl pyrophosphate synthase-associated protein 2 6.0 0.3 5

Interstitial collagenase 7.1 0.5 4 Pigment epithelium-derived factor 9.4 0.2 7

S-formylglutathione hydrolase 7.1 0.5 4 Plasma kallikrein 8.8 0.2 7

Carcinoembryonic antigen-related cell adhesion molecule 1 7.1 0.6 4 Plasma protease C1 inhibitor 9.9 0.3 7

ATP-dependent dihydroxyacetone kinase/FAD-AMP lyase 7.0 1.1 4 Plasma serine protease inhibitor 8.0 0.2 7

EH domain-containing protein 1 7.0 0.3 4 Plasminogen 8.9 0.4 7

Dihydrolipoyl dehydrogenase, mitochondrial 7.0 0.6 4 Plasminogen activator inhibitor 1 8.2 0.3 7

Nucleolin 7.0 0.3 4 Plastin-2 9.8 0.5 7

Flotillin-1 7.0 0.6 4 Platelet basic protein 7.3 0.7 5

Guanine nucleotide-binding protein subunit b-4 7.0 0.3 4 Platelet glycoprotein Ib a chain 7.8 0.2 7

Electron transfer flavoprotein subunit b 6.9 0.4 4 Platelet-activating factor acetylhydrolase IB subunit a 6.7 0.3 3

X-ray repair cross-complementing protein 5 6.9 0.4 4 Platelet-activating factor acetylhydrolase IB subunit b 8.0 0.3 6

Neural cell adhesion molecule 1 6.9 0.3 4 Platelet-activating factor acetylhydrolase IB subunit g 6.9 0.4 3

Integrin beta-1 6.9 0.2 4 Pleckstrin 6.7 1

Glutamate dehydrogenase 1, mitochondrial 6.9 0.3 4 Plectin 7.0 0.7 7

Reticulon-4 6.9 0.5 4 PML-RARA-regulated adapter molecule 1 7.0 0.3 5

Ras-related protein Rab-5C 6.9 0.6 4 Poly(ADP-ribose) glycohydrolase ARH3 6.8 0.3 2

T-complex protein 1 subunit g 6.9 0.4 4 Polyadenylate-binding protein 1/3 7.2 0.6 4

Ras-related protein Rab-10 6.9 0.5 4 Polypyrimidine tract-binding protein 1 6.9 0.7 4

Polypyrimidine tract-binding protein 1 6.9 0.7 4 Porphobilinogen deaminase 6.7 1.3 5

Sialic acid-binding Ig-like lectin 5/14 6.9 0.3 4 Prefoldin subunit 2 6.5 0.4 2

Pyruvate kinase PKLR 6.8 0.5 4 Prefoldin subunit 3 7.2 1

Zyxin 6.8 0.5 4 Pregnancy zone protein 7.5 0.5 7

Prolyl endopeptidase 6.8 0.5 4 Prelamin-A/C 6.9 0.8 6

Leukocyte surface antigen CD47 6.8 0.6 4 Prenylcysteine oxidase 1 7.2 0.3 4

Protein disulfide-isomerase A4 6.8 1.0 4 Procollagen C-endopeptidase enhancer 1 7.7 0.2 6

Signal transducing adapter molecule 1 6.8 0.5 4 Profilin-1 8.7 0.5 7

Alkaline phosphatase, tissue-nonspecific isozyme 6.7 0.8 4 Programmed cell death 6-interacting protein 7.5 0.6 7

T-complex protein 1 subunit a 6.7 0.7 4 Programmed cell death protein 6 7.5 0.5 5

26S proteasome non-ATPase regulatory subunit 9 6.7 0.5 4 Prohibitin 6.6 1

Target of Myb protein 1 6.7 0.5 4 Prohibitin-2 6.2 0.3 5

Proteolipid protein 2 6.7 0.4 4 Interleukin-16/Pro-interleukin-16 6.0 1

Phosphatidylinositol transfer protein a isoform 6.7 0.3 4 Proliferation-associated protein 2G4 6.8 0.7 5

Uroporphyrinogen decarboxylase 6.7 0.6 4 Prolyl endopeptidase 6.8 0.5 4

Formin-binding protein 1 6.7 0.3 4 Prosaposin 7.4 0.4 6

Obg-like ATPase 1 6.6 0.6 4 Prostaglandin-H2 D-isomerase 8.4 0.6 7

Septin-7 6.5 0.3 4 Proteasome activator complex subunit 1 8.1 0.5 7

Ig kappa chain V-I region CAR 6.5 0.5 4 Proteasome activator complex subunit 2 7.3 0.7 7

Ubiquitin-conjugating enzyme E2 G1 6.4 0.3 4 Proteasome subunit a type 7.7 0.5 7

Eukaryotic translation initiation factor 4B 6.4 0.3 4 Proteasome subunit a type-1 8.2 0.5 7

Ras-related protein Rab-8B 6.4 0.9 4 Proteasome subunit a type-3 7.7 0.5 6

Coronin-1C 6.4 0.4 4 Proteasome subunit a type-7 8.1 0.7 7

Dysferlin 6.4 1.3 4 Proteasome subunit alpha type-2 8.1 0.5 6

Vesicle-associated membrane protein-associated protein A/B/C 6.3 0.5 4 Proteasome subunit alpha type-4 7.9 0.5 7

Twinfilin-1 6.3 0.8 4 Proteasome subunit alpha type-5 7.9 0.7 7

Serpin B8 6.2 0.4 4 Proteasome subunit b type 7.0 0.7 6

Sialic acid synthase 6.2 0.8 4 Proteasome subunit b type-10 7.4 0.9 4

Syntaxin-3 6.1 0.8 4 Proteasome subunit b type-2 8.1 0.7 7

ATP-binding cassette sub-family B member 6, mitochondrial 6.0 0.6 4 Proteasome subunit b type-4 7.1 0.5 6

Collagen alpha-1(XIV) chain 8.6 0.7 3 Proteasome subunit b type-5 7.0 0.6 7

Low affinity immunoglobulin gamma Fc region receptor III-B 8.1 0.6 3 Proteasome subunit b type-6 7.5 0.6 6

Olfactory receptor 51J1 7.9 0.7 3 Proteasome subunit b type-7 6.7 0.7 6

V-type proton ATPase subunit G 1 7.7 0.9 3 Proteasome subunit b type-8 7.8 0.4 4

Neurofilament light polypeptide 7.7 0.7 3 Proteasome subunit beta type-1 7.8 0.9 6

Hsc70-interacting protein 7.7 0.3 3 Proteasome subunit beta type-3 7.6 0.6 5

Ubiquitin carboxyl-terminal hydrolase 15 7.6 0.4 3 Protein 4.1 7.2 0.3 5

Protein FAM107B 7.6 0.3 3 Protein arginine N-methyltransferase 5 6.8 1

Caspase recruitment domain-containing protein 9 7.6 0.4 3 Protein argonaute-2 6.7 0.1 3

Serum amyloid A-2 protein 7.5 1.3 3 Protein canopy homolog 3 6.4 1

LIM and SH3 domain protein 1 7.5 0.2 3 Protein CutA 7.7 0.5 5

Dynactin subunit 2 7.5 0.5 3 Protein DDI1 homolog 2 6.3 0.4 2

Histone H1.3 7.5 0.2 3 Protein diaphanous homolog 1 7.1 0.8 5

Glycolipid transfer protein 7.5 0.6 3 Protein disulfide-isomerase A3 7.8 0.3 7

Ig kappa chain V-I region HK101 7.4 0.5 3 Protein disulfide-isomerase A4 6.8 1.0 4

Cytochrome b5 7.4 0.3 3 Protein disulfide-isomerase A6 7.4 0.5 6

Stathmin 7.4 0.3 3 Protein DJ-1 8.0 0.5 6

N-acetylgalactosamine-6-sulfatase 7.4 0.2 3 Protein EVI2B 6.7 1

S-methyl-5-thioadenosine phosphorylase 7.4 0.5 3 Protein FAM107B 7.6 0.3 3

Septin-9 7.4 0.7 3 Protein FAM49B 8.2 0.8 6

Cytidine deaminase 7.3 0.7 3 Protein Hook homolog 3 7.2 1

S-adenosylmethionine synthase isoform type-2 7.3 0.4 3 Protein kinase C and casein kinase substrate in neurons protein 1 6.8 1

THO complex subunit 4 7.3 0.1 3 Protein kinase C and casein kinase substrate in neurons protein 2 7.6 0.3 6

Serum paraoxonase/lactonase 3 7.3 0.4 3 Protein Niban 7.3 0.2 2

Ficolin-2 7.3 0.4 3 Protein phosphatase 1 regulatory subunit 12A 7.0 0.1 2

Alpha-adducin 7.3 0.8 3 Protein phosphatase 1 regulatory subunit 7 7.1 1

Liver carboxylesterase 1 7.3 0.1 3 Protein phosphatase 1A/B 7.2 0.5 4

26S proteasome non-ATPase regulatory subunit 2 7.2 0.2 3 Protein S100-A1 6.8 0.5 2

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase g-2 7.2 0.5 3 Protein S100-A11 8.2 0.9 7

Solute carrier family 2, facilitated glucose transporter member 3/14 7.2 0.3 3 Protein S100-A12 8.5 1.2 7

RNA-binding motif protein, X chromosome 7.2 0.2 3 Protein S100-A13 7.5 1

Myelin proteolipid protein 7.2 0.8 3 Protein S100-A4 8.4 0.5 7

Collagen alpha-1(XVIII) chain 7.1 0.3 3 Protein S100-A6 8.4 0.9 7

Chromobox protein homolog 3 7.1 0.5 3 Protein S100-A8 10.2 0.5 7

Tropomodulin-3 7.1 0.2 3 Protein S100-A9 10.8 0.5 7

Tissue alpha-L-fucosidase 7.1 0.5 3 Protein S100-B 7.6 1.7 2

Nucleoprotein TPR 7.1 0.3 3 Protein S100-P 8.6 0.8 7

Far upstream element-binding protein 1 7.1 0.0 3 Protein SET 7.7 0.9 5

Laminin subunit alpha-5 7.1 0.1 3 Protein XRP2 7.4 0.4 4

Ragulator complex protein LAMTOR5 7.1 0.3 3 Protein Z-dependent protease inhibitor 8.0 0.4 7

Hsp90 co-chaperone Cdc37 7.1 0.7 3 Protein-arginine deiminase type-2 8.0 0.4 4

Translin-associated protein X 7.1 0.4 3 Protein-arginine deiminase type-4 7.6 0.6 5

60 kDa SS-A/Ro ribonucleoprotein 7.0 0.4 3 Protein-glutamine gamma-glutamyltransferase 2 7.0 0.8 2

Sulfide:quinone oxidoreductase, mitochondrial 7.0 0.4 3 Protein-L-isoaspartate O-methyltransferase 7.0 0.6 6

Enhancer of rudimentary homolog 7.0 0.2 3 Proteoglycan 4 7.8 0.5 7

Translationally-controlled tumor protein 7.0 0.5 3 Proteolipid protein 2 6.7 0.4 4

Platelet-activating factor acetylhydrolase IB subunit g 6.9 0.4 3 Prothrombin 9.2 0.4 7

Lysosome-associated membrane glycoprotein 1 6.9 0.6 3 Prothymosin alpha 4.9 1

Nuclear pore membrane glycoprotein 210 6.9 0.4 3 Pterin-4-alpha-carbinolamine dehydratase 6.9 0.4 3

T-complex protein 1 subunit d 6.9 0.1 3 Purine nucleoside phosphorylase 8.6 0.6 7

Guanine nucleotide-binding protein subunit g 6.9 0.8 3 Puromycin-sensitive aminopeptidase 7.7 0.7 7

Histidine--tRNA ligase, cytoplasmic 6.9 0.4 3 Putative deoxyribose-phosphate aldolase 7.8 0.5 2

Eukaryotic initiation factor 4A-I 6.9 0.8 3 Putative GTP cyclohydrolase 1 type 2 NIF3L1 7.1 0.7 6

Ig heavy chain V-III region ZAP 6.9 0.1 3 Putative nucleoside diphosphate kinase 7.1 1

Hemoglobin subunit theta-1 6.9 0.4 3 Pyridoxal kinase 6.8 1

Pterin-4-alpha-carbinolamine dehydratase 6.9 0.4 3 Pyridoxal phosphate phosphatase 7.2 0.3 2

N-myc-interactor 6.9 0.2 3 Pyruvate kinase (PKM2) 7.2 0.5 6

Synaptotagmin-1 6.8 0.5 3 Pyruvate kinase (PKM3) 8.9 0.7 7

Isoamyl acetate-hydrolyzing esterase 1 homolog 6.8 0.3 3 Pyruvate kinase PKLR 6.8 0.5 4

Alcohol dehydrogenase [NADP+] 6.8 0.5 3 Quinone oxidoreductase PIG3 7.0 0.6 5

NADH-cytochrome b5 reductase 3 6.8 0.5 3 Rab GDP dissociation inhibitor a 7.9 0.7 4

MOB kinase activator 1A/B 6.8 0.2 3 Rab GDP dissociation inhibitor beta 8.7 0.6 7

Rho GTPase-activating protein 1 6.7 0.7 3 Radixin 6.6 0.2 2

Mitochondrial fission 1 protein 6.7 0.9 3 Ragulator complex protein LAMTOR3 6.4 1

Protein argonaute-2 6.7 0.1 3 Ragulator complex protein LAMTOR5 7.1 0.3 3

Platelet-activating factor acetylhydrolase IB subunit a 6.7 0.3 3 Ras GTPase-activating-like protein IQGAP1 8.1 1.1 7

Tumor necrosis factor alpha-induced protein 8 6.7 0.4 3 RAS protein activator like-3 6.5 1

Vesicle-fusing ATPase 6.7 0.5 3 Ras suppressor protein 1 6.9 0.5 5

Dihydropyrimidinase-related protein 2 6.7 1.1 3 Ras-related C3 botulinum toxin substrate 2 7.6 0.5 5

Complement receptor type 1 6.7 0.6 3 Ras-related protein Rab-10 6.9 0.5 4

Epidermal growth factor receptor substrate 15-like 1 6.6 0.4 3 Ras-related protein Rab-11 7.8 0.6 6

N-acetylglucosamine-6-sulfatase 6.6 0.7 3 Ras-related protein Rab-1A 6.9 0.6 5

Dipeptidyl peptidase 1 6.6 1.0 3 Ras-related protein Rab-21 6.8 0.5 2

Cytokine receptor-like factor 3 6.6 0.3 3 Ras-related protein Rab-5A/B 6.7 0.6 2

C-type lectin domain family 11 member A 6.6 0.2 3 Ras-related protein Rab-5C 6.9 0.6 4

Guanine nucleotide-binding protein G(i) subunit a-2 6.6 0.2 3 Ras-related protein Rab-7a 7.6 0.6 4

Fatty acid-binding protein, heart 6.5 0.6 3 Ras-related protein Rab-8A 6.3 0.7 2

Small nuclear ribonucleoprotein Sm D2 6.5 0.3 3 Ras-related protein Rab-8B 6.4 0.9 4

Cytoplasmic FMR1-interacting protein 2 6.5 0.7 3 Ras-related protein Rap-1b 7.3 0.9 7

Calcineurin B homologous protein 1 6.4 0.7 3 Receptor-type tyrosine-protein phosphatase C 7.3 0.6 5

Hypoxia up-regulated protein 1 6.4 0.4 3 Receptor-type tyrosine-protein phosphatase eta 6.5 1

3-mercaptopyruvate sulfurtransferase 6.2 0.8 3 Resistin 7.7 0.6 7

Nuclear mitotic apparatus protein 1 6.2 1.5 3 Reticulon-1 6.7 1

60 kDa heat shock protein, mitochondrial 6.1 0.5 3 Reticulon-3 6.3 1.5 2

Integral membrane protein 2B 6.0 0.8 3 Reticulon-4 6.9 0.5 4

Cullin-2 6.0 0.2 3 Retinal dehydrogenase 1 7.6 0.8 7

ATP synthase subunit d, mitochondrial 6.0 0.3 3 Retinoblastoma-like protein 1 8.0 0.7 4

Ankyrin repeat domain-containing protein 36A/B 5.8 0.1 3 Retinol-binding protein 4 8.9 0.2 7

Voltage-dependent anion-selective channel protein 2 8.4 0.2 2 Rho GDP-dissociation inhibitor 1 7.8 0.6 6

Tenascin-R 8.1 0.6 2 Rho GDP-dissociation inhibitor 2 8.2 0.8 7

Putative deoxyribose-phosphate aldolase 7.8 0.5 2 Rho GTPase-activating protein 1 6.7 0.7 3

Nuclear transport factor 2 7.7 1.3 2 Rho GTPase-activating protein 25 6.8 0.6 2

Serine/threonine-protein phosphatase 2A catalytic subunit a/b isoform 7.7 0.1 2 Rho GTPase-activating protein 30 5.5 0.1 2

Thymosin beta-10 7.7 0.2 2 Rho GTPase-activating protein 4 6.4 0.4 2

Adenylate kinase isoenzyme 1 7.6 0.0 2 Rho-associated protein kinase 1 6.7 1

Protein S100-B 7.6 1.7 2 Rho-related GTP-binding protein RhoG 6.6 1

Glycogen debranching enzyme 7.5 0.6 2 Ribonuclease inhibitor 7.7 0.5 5

2,3-cyclic-nucleotide 3-phosphodiesterase 7.5 0.4 2 Ribonuclease T2 6.9 1.1 6

Vacuolar protein sorting-associated protein 26A 7.5 0.3 2 Ribose-5-phosphate isomerase 7.5 0.3 4

Ubiquitin carboxyl-terminal hydrolase isozyme L1 7.5 0.2 2 Ribose-phosphate pyrophosphokinase 1 6.6 0.8 5

Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit b-1 7.5 0.2 2 Ribosyldihydronicotinamide dehydrogenase [quinone] 6.7 0.7 5

Echinoderm microtubule-associated protein-like 2 7.5 0.2 2 Ribulose-phosphate 3-epimerase 7.4 0.0 2

Ubiquitin-like modifier-activating enzyme ATG7 7.4 0.9 2 RNA-binding motif protein, X chromosome 7.2 0.2 3

Cullin-3 7.4 0.2 2 RNA-binding protein EWS 6.9 0.9 2

Ribulose-phosphate 3-epimerase 7.4 0.0 2 S-adenosylmethionine synthase isoform type-2 7.3 0.4 3

Haloacid dehalogenase-like hydrolase domain-containing protein 2 7.4 0.1 2 Scavenger receptor cysteine-rich type 1 protein M130/Soluble CD163 7.4 0.2 5 Thymopoietin 7.4 0.2 2 Sec1 family domain-containing protein 1 8.8 0.5 7

10 kDa heat shock protein, mitochondrial 7.4 0.1 2 Secernin-1 7.0 1

Beta-actin-like protein 2 7.4 0.2 2 Secernin-2 7.1 1

Interferon-induced guanylate-binding protein 1/2 7.3 0.2 2 Selenium-binding protein 1 8.4 0.4 6

Tubulin beta-4A chain 7.3 0.2 2 Selenoprotein P 8.1 0.5 7

Protein Niban 7.3 0.2 2 Septin-7 6.5 0.3 4

Nascent polypeptide-associated complex subunit a 7.3 0.2 2 Septin-9 7.4 0.7 3

Calcium uniporter protein, mitochondrial 7.3 0.3 2 Serine/arginine repetitive matrix protein 1 6.5 0.6 2

Uncharacterized protein C9orf142 7.3 0.3 2 Serine/arginine-rich splicing factor 3 7.1 0.4 4

Pyridoxal phosphate phosphatase 7.2 0.3 2 Serine/threonine-protein kinase 4 6.6 1

ADP-sugar pyrophosphatase 7.2 0.1 2 Serine/threonine-protein kinase OSR1 6.9 0.5 7

60S acidic ribosomal protein P2 7.2 0.3 2 Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit Ab 6.7 0.4 2

ATP-dependent RNA helicase DDX39A 7.2 0.2 2 Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit Aa 7.0 0.7 5

Peroxisomal acyl-coenzyme A oxidase 1 7.2 0.4 2 Serine/threonine-protein phosphatase 2A activator 7.2 0.7 6

Barrier-to-autointegration factor 7.2 0.1 2 Serine/threonine-protein phosphatase 2A catalytic subunit a/b isoform 7.7 0.1 2

Latexin 7.1 0.1 2 Serine/threonine-protein phosphatase CPPED1 8.3 0.5 7

T-complex protein 1 subunit epsilon 7.1 0.6 2 Serotransferrin 11.0 0.1 7

Acyl-protein thioesterase 1 7.1 0.1 2 Serpin B10 7.8 0.8 7

Syntaxin-7 7.1 0.3 2 Serpin B3/B4 6.7 1

High affinity choline transporter 1 7.1 0.1 2 Serpin B6 7.1 0.6 7

U6 snRNA-associated Sm-like protein LSm8 7.1 0.8 2 Serpin B8 6.2 0.4 4

Formin-like protein 1 7.0 0.1 2 Serum albumin 11.9 0.1 7

Elongation factor 1-b 7.0 0.1 2 Serum amyloid A-1 protein 8.5 1.7 6

Apoptosis inhibitor 5 7.0 1.1 2 Serum amyloid A-2 protein 7.5 1.3 3

F-box only protein 7 7.0 0.0 2 Serum amyloid A-4 protein 8.8 0.3 7

Ketosamine-3-kinase 7.0 0.1 2 Serum amyloid P-component 9.3 0.3 7

Crk-like protein 7.0 0.1 2 Serum paraoxonase/arylesterase 1 9.2 0.2 7

DNA topoisomerase 2 7.0 0.1 2 Serum paraoxonase/lactonase 3 7.3 0.4 3

AP-2 complex subunit m 7.0 0.2 2 Sex hormone-binding globulin 7.9 0.3 7

DNA-binding protein RFX7 7.0 0.7 2 S-formylglutathione hydrolase 7.1 0.5 4

Importin-5 7.0 0.3 2 SH3 domain-binding glutamic acid-rich-like protein 7.8 0.5 7

COP9 signalosome complex subunit 4 7.0 0.2 2 SH3 domain-binding glutamic acid-rich-like protein 3 7.9 0.5 7

Protein phosphatase 1 regulatory subunit 12A 7.0 0.1 2 Sialic acid synthase 6.2 0.8 4

26S protease regulatory subunit 7 7.0 0.3 2 Sialic acid-binding Ig-like lectin 5/14 6.9 0.3 4

Adenine phosphoribosyltransferase 7.0 1.1 2 Signal transducing adapter molecule 1 6.8 0.5 4

Protein-glutamine gamma-glutamyltransferase 2 7.0 0.8 2 Small glutamine-rich tetratricopeptide repeat-containing protein a 6.8 1

AP-2 complex subunit b 7.0 0.5 2 Small nuclear ribonucleoprotein E 6.9 0.3 2

RNA-binding protein EWS 6.9 0.9 2 Small nuclear ribonucleoprotein Sm D2 6.5 0.3 3

Mitochondrial peptide methionine sulfoxide reductase 6.9 0.4 2 Small ubiquitin-related modifier 1 6.4 1

ATPase ASNA1 6.9 1.0 2 Small ubiquitin-related modifier 2/3/4 7.5 0.3 5

Myelin basic protein 6.9 1.3 2 S-methyl-5-thioadenosine phosphorylase 7.4 0.5 3

Small nuclear ribonucleoprotein E 6.9 0.3 2 Smoothelin-like protein 2 8.3 0.6 5

Cytosol aminopeptidase 6.9 0.5 2 SNARE-associated protein Snapin 7.2 1

Bifunctional purine biosynthesis protein PURH 6.9 0.8 2 Sodium/potassium-transporting ATPase subunit a-1 7.5 0.5 6

Protein S100-A1 6.8 0.5 2 Sodium/potassium-transporting ATPase subunit b-1 7.1 1

Fructose-1,6-bisphosphatase isozyme 2 6.8 0.2 2 Solute carrier family 2, facilitated glucose transporter member 1 7.6 1.2 7

Isocitrate dehydrogenase [NADP], mitochondrial 6.8 0.1 2 Solute carrier family 2, facilitated glucose transporter member 3/14 7.2 0.3 3

Voltage-gated potassium channel subunit b-2 6.8 0.7 2 Sorcin 7.0 0.5 5

N(G),N(G)-dimethylarginine dimethylaminohydrolase 1 6.8 1.0 2 SPARC 8.1 0.6 7

DnaJ homolog subfamily C member 13 6.8 0.3 2 SPARC-like protein 1 7.0 0.6 6

CD97 antigen 6.8 0.3 2 Spectrin alpha chain, erythrocytic 1 8.6 0.9 7

Src kinase-associated phosphoprotein 2 6.8 0.4 2 Spectrin alpha chain, non-erythrocytic 1 8.3 1.1 7

Rho GTPase-activating protein 25 6.8 0.6 2 Spectrin beta chain, erythrocytic 8.5 1.0 7

Ganglioside GM2 activator 6.8 0.4 2 Spectrin beta chain, non-erythrocytic 1 8.0 0.9 6

Ras-related protein Rab-21 6.8 0.5 2 S-phase kinase-associated protein 1 7.7 0.4 5

Poly(ADP-ribose) glycohydrolase ARH3 6.8 0.3 2 Splicing factor U2AF 65 kDa subunit 6.9 0.6 5

Visinin-like protein 1 6.8 2.0 2 Splicing factor, proline- and glutamine-rich 6.7 0.5 2

Lysosomal alpha-mannosidase 6.7 0.4 2 Src kinase-associated phosphoprotein 2 6.8 0.4 2

Trypsin-3 6.7 0.2 2 Stathmin 7.4 0.3 3

26S proteasome non-ATPase regulatory subunit 5 6.7 0.4 2 STE20-like serine/threonine-protein kinase 6.2 0.3 2

Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit Ab 6.7 0.4 2 Stress-70 protein, mitochondrial 6.2 1

Eosinophil peroxidase 6.7 0.5 2 Stress-induced-phosphoprotein 1 7.5 0.6 7

Alpha-crystallin B chain 6.7 0.3 2 Sulfhydryl oxidase 1 8.1 0.1 7

Heterochromatin protein 1-binding protein 3 6.7 0.4 2 Sulfide:quinone oxidoreductase, mitochondrial 7.0 0.4 3

UMP-CMP kinase 6.7 0.0 2 Superoxide dismutase [Cu-Zn] 6.9 1.3 6

Ras-related protein Rab-5A/B 6.7 0.6 2 Superoxide dismutase [Mn], mitochondrial 8.4 0.5 7

Collagen alpha-2(IV) chain 6.7 0.1 2 Synaptic vesicle membrane protein VAT-1 homolog 7.7 0.6 6

Splicing factor, proline- and glutamine-rich 6.7 0.5 2 Synaptosomal-associated protein 25 7.4 1

Enolase-phosphatase E1 6.6 0.3 2 Synaptotagmin-1 6.8 0.5 3

Radixin 6.6 0.2 2 Syndecan-1 6.9 1 cAMP-dependent protein kinase type II-a regulatory subunit 6.6 0.6 2 Syntaxin-1A 6.9 1

Serine/arginine repetitive matrix protein 1 6.5 0.6 2 Syntaxin-1B 7.3 1

Wiskott-Aldrich syndrome protein 6.5 0.0 2 Syntaxin-3 6.1 0.8 4

V-type proton ATPase subunit C 1 6.5 0.8 2 Syntaxin-7 7.1 0.3 2

Prefoldin subunit 2 6.5 0.4 2 Syntaxin-binding protein 1 5.9 0.5 2

Lamin-B receptor 6.5 0.2 2 Syntaxin-binding protein 2 6.7 1

E3 ubiquitin-protein ligase CBL 6.5 0.7 2 Syntenin-1 7.3 1.4 5

Nuclear ubiquitous casein and cyclin-dependent kinase substrate 1 6.5 0.2 2 Talin-1 8.5 1.0 7

Rho GTPase-activating protein 4 6.4 0.4 2 Target of Myb protein 1 6.7 0.5 4

Neuromodulin 6.4 0.5 2 Target of Nesh-SH3 7.7 0.5 6

Endoplasmic reticulum aminopeptidase 1 6.4 0.1 2 T-complex protein 1 subunit a 6.7 0.7 4

UPF0556 protein C19orf10 6.4 0.5 2 T-complex protein 1 subunit b 7.3 0.4 6

Calsyntenin-1 6.3 0.1 2 T-complex protein 1 subunit d 6.9 0.1 3

Ras-related protein Rab-8A 6.3 0.7 2 T-complex protein 1 subunit epsilon 7.1 0.6 2

Citrate synthase 6.3 0.9 2 T-complex protein 1 subunit g 6.9 0.4 4

Reticulon-3 6.3 1.5 2 T-complex protein 1 subunit theta 7.1 0.6 4

Protein DDI1 homolog 2 6.3 0.4 2 T-complex protein 1 subunit zeta 7.2 0.2 7

Thioredoxin-related transmembrane protein 4 6.2 0.1 2 Tenascin 8.0 0.3 7

Coatomer subunit b 6.2 0.3 2 Tenascin-R 8.1 0.6 2

Importin-9 6.2 0.3 2 Thioredoxin 8.7 0.4 7

Glutathione S-transferase Mu 1/4 6.2 0.9 2 Thioredoxin domain-containing protein 17 7.2 0.5 4

High mobility group protein HMG-I/HMG-Y 6.2 0.1 2 Thioredoxin reductase 1, cytoplasmic 7.2 0.7 5

Amyloid beta A4 protein 6.2 0.0 2 Thioredoxin-dependent peroxide reductase, mitochondrial 7.4 0.6 4

STE20-like serine/threonine-protein kinase 6.2 0.3 2 Thioredoxin-like protein 1 6.5 0.4 5

CD109 antigen 6.1 0.9 2 Thioredoxin-related transmembrane protein 4 6.2 0.1 2

Eukaryotic translation initiation factor 2 subunit 1 6.1 0.1 2 THO complex subunit 4 7.3 0.1 3

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase b-2 6.0 0.6 2 Thrombospondin-2 7.5 0.4 7

Syntaxin-binding protein 1 5.9 0.5 2 Thymidine phosphorylase 8.0 0.6 6

Non-histone chromosomal protein HMG-14 5.9 0.4 2 Thymopoietin 7.4 0.2 2

Rho GTPase-activating protein 30 5.5 0.1 2 Thymosin b-4 8.5 0.4 7

COP9 signalosome complex subunit 3 5.4 0.6 2 Thymosin beta-10 7.7 0.2 2

Alpha-internexin 8.0 1 Thyroxine-binding globulin 8.4 0.2 7

Neurofilament medium polypeptide 8.0 1 Tissue alpha-L-fucosidase 7.1 0.5 3

Collagen alpha-1(VII) chain 8.0 1 Toll-interacting protein 7.2 1

Calpain-2 catalytic subunit 7.9 1 Transaldolase 8.9 0.5 7

Desmoplakin 7.8 1 Transcobalamin-1 7.1 0.6 4

Major prion protein 7.8 1 Transcription factor 20 7.7 0.4 5

Nicotinamide mononucleotide adenylyltransferase 1 7.7 1 Transferrin receptor protein 1, serum form 7.2 0.2 6

Transgelin 7.6 1 Transforming growth factor-b-induced protein ig-h3 9.0 0.3 7

Ester hydrolase C11orf54 7.6 1 Transforming protein RhoA/B/C 7.2 0.7 6

V-type proton ATPase subunit E 1 7.5 1 Transgelin 7.6 1

ATP synthase subunit beta, mitochondrial 7.5 1 Transgelin-2 8.0 0.6 6

NEDD8 7.5 1 Transitional endoplasmic reticulum ATPase 8.3 0.7 7

Myosin light chain 4 7.5 1 Transketolase 9.1 0.6 7

Protein S100-A13 7.5 1 Translationally-controlled tumor protein 7.0 0.5 3

Aconitate hydratase, mitochondrial 7.5 1 Translin 7.5 1.0 6

Synaptosomal-associated protein 25 7.4 1 Translin-associated protein X 7.1 0.4 3

Dickkopf-related protein 3 7.4 1 Transmembrane emp24 domain-containing protein 9 7.2 1

Ubiquitin carboxyl-terminal hydrolase isozyme L3 7.4 1 Transthyretin 10.4 0.2 7

Glycophorin-A 7.4 1 Triosephosphate isomerase 8.8 0.5 7

NAD(P)H-hydrate epimerase 7.3 1 Tripeptidyl-peptidase 1 6.3 1

Phospholipid scramblase 1 7.3 1 Tripeptidyl-peptidase 2 7.2 0.5 5

Guanine deaminase 7.3 1 Tropomodulin-3 7.1 0.2 3

Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit b-3 7.3 1 Tropomyosin alpha-1 chain 7.1 0.5 5

Myc box-dependent-interacting protein 1 7.3 1 Trypsin-3 6.7 0.2 2

Syntaxin-1B 7.3 1 Trypstatin 9.5 0.3 7

Neutral alpha-glucosidase AB 7.3 1 Tryptophan--tRNA ligase, cytoplasmic 7.8 0.4 7

Voltage-dependent anion-selective channel protein 1 7.3 1 Tubulin a-1C chain 7.7 0.6 7

Heat shock protein 105 kDa 7.2 1 Tubulin alpha-3C/D/E chain 7.2 0.6 7

Wiskott-Aldrich syndrome protein family member 2 7.2 1 Tubulin b-4B chain 8.0 0.5 7

Phospholysine phosphohistidine inorganic pyrophosphate phosphatase 7.2 1 Tubulin beta chain 7.2 0.3 5

Toll-interacting protein 7.2 1 Tubulin beta-4A chain 7.3 0.2 2

Transmembrane emp24 domain-containing protein 9 7.2 1 Tubulin polymerization-promoting protein 6.9 1

Protein Hook homolog 3 7.2 1 Tubulin-specific chaperone A 7.4 0.4 5

Low molecular weight phosphotyrosine protein phosphatase 7.2 1 Tumor necrosis factor alpha-induced protein 8 6.7 0.4 3

Prefoldin subunit 3 7.2 1 Tumor protein D54 7.6 0.4 6

Exportin-1 7.2 1 Tumor-associated calcium signal transducer 2 6.5 1

SNARE-associated protein Snapin 7.2 1 Twinfilin-1 6.3 0.8 4

Sodium/potassium-transporting ATPase subunit b-1 7.1 1 Twinfilin-2 6.9 0.7 5

NAD-dependent protein deacetylase sirtuin-2 7.1 1 Tyrosine-protein phosphatase non-receptor type 6 7.3 0.5 5

Mini-chromosome maintenance complex-binding protein 7.1 1 Tyrosine-protein phosphatase non-receptor type substrate 1 7.3 0.6 6

Isoaspartyl peptidase/L-asparaginase 7.1 1 U6 snRNA-associated Sm-like protein LSm8 7.1 0.8 2

Delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial 7.1 1 Ubiquilin-1 6.8 1

Erlin-2 7.1 1 Ubiquitin carboxyl-terminal hydrolase 7.0 0.3 5

Secernin-2 7.1 1 Ubiquitin carboxyl-terminal hydrolase 15 7.6 0.4 3

Protein phosphatase 1 regulatory subunit 7 7.1 1 Ubiquitin carboxyl-terminal hydrolase 5 6.9 0.5 5

Beta-adducin 7.1 1 Ubiquitin carboxyl-terminal hydrolase isozyme L1 7.5 0.2 2

ATP synthase subunit alpha, mitochondrial 7.1 1 Ubiquitin carboxyl-terminal hydrolase isozyme L3 7.4 1

Putative nucleoside diphosphate kinase 7.1 1 Ubiquitin thioesterase OTUB1 7.6 0.2 5

Exportin-7 7.1 1 Ubiquitin-60S ribosomal protein L40 8.5 0.6 7

Cadherin-1 7.0 1 Ubiquitin-conjugating enzyme E2 G1 6.4 0.3 4

Dihydropyrimidine dehydrogenase [NADP(+)] 7.0 1 Ubiquitin-conjugating enzyme E2 K 7.4 0.7 4

Microtubule-associated protein 1B 7.0 1 Ubiquitin-conjugating enzyme E2 L3 7.7 1.0 6

Delta(3,5)-Delta(2,4)-dienoyl-CoA isomerase, mitochondrial 7.0 1 Ubiquitin-conjugating enzyme E2 N 7.7 0.6 7

Secernin-1 7.0 1 Ubiquitin-conjugating enzyme E2 variant 1 7.9 1.0 5

Fumarate hydratase, mitochondrial 6.9 1 Ubiquitin-like modifier-activating enzyme 1 7.3 0.7 6

Mitochondrial 2-oxoglutarate/malate carrier protein 6.9 1 Ubiquitin-like modifier-activating enzyme ATG7 7.4 0.9 2

Charged multivesicular body protein 4a 6.9 1 Ubiquitin-like-conjugating enzyme ATG3 6.3 1

NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial 6.9 1 UDP-glucose:glycoprotein glucosyltransferase 1 5.9 1

Tubulin polymerization-promoting protein 6.9 1 UMP-CMP kinase 6.7 0.0 2

Calcium/calmodulin-dependent protein kinase type II subunit g 6.9 1 Uncharacterized protein C9orf142 7.3 0.3 2

Syndecan-1 6.9 1 Uncharacterized protein KIAA1328 7.3 0.8 7

Golgi membrane protein 1 6.9 1 Unconventional myosin-Ie/f 7.0 0.4 5

Nck-associated protein 1-like 6.9 1 Unconventional myosin-XVIIIa 6.4 1

26S proteasome non-ATPase regulatory subunit 6 6.9 1 UPF0556 protein C19orf10 6.4 0.5 2

Syntaxin-1A 6.9 1 Uroporphyrinogen decarboxylase 6.7 0.6 4

Myelin P2 protein 6.8 1 UTP--glucose-1-phosphate uridylyltransferase 7.7 0.9 7

Ubiquilin-1 6.8 1 UV excision repair protein RAD23 homolog B 7.4 0.4 5

Small glutamine-rich tetratricopeptide repeat-containing protein a 6.8 1 Vacuolar protein sorting-associated protein 26A 7.5 0.3 2

Pyridoxal kinase 6.8 1 Vacuolar protein sorting-associated protein 35 7.1 0.5 4

Calcineurin subunit B type 1 6.8 1 Vascular non-inflammatory molecule 2 7.5 0.4 4

Protein arginine N-methyltransferase 5 6.8 1 Vasodilator-stimulated phosphoprotein 7.7 0.6 5

Phosphatidylinositol 5-phosphate 4-kinase type-2 a/b 6.8 1 Vasorin 8.2 0.6 7

Protein kinase C and casein kinase substrate in neurons protein 1 6.8 1 Versican core protein 8.5 0.2 7

26S protease regulatory subunit 6A 6.8 1 Vesicle transport through interaction with t-SNAREs homolog 1B 7.8 0.4 7

Activated RNA polymerase II transcriptional coactivator p15 6.7 1 Vesicle-associated membrane protein-associated protein A/B/C 6.3 0.5 4

Pleckstrin 6.7 1 Vesicle-fusing ATPase 6.7 0.5 3

Cytochrome c oxidase subunit 4 isoform 1, mitochondrial 6.7 1 Vimentin 9.6 0.5 7

Protein EVI2B 6.7 1 Vinculin 8.9 0.5 7

4-trimethylaminobutyraldehyde dehydrogenase 6.7 1 Visinin-like protein 1 6.8 2.0 2

Syntaxin-binding protein 2 6.7 1 Vitamin D-binding protein 9.9 0.1 7

Calretinin 6.7 1 Vitamin K-dependent protein S 8.8 0.3 7

Hepatoma-derived growth factor-related protein 2 6.7 1 Vitamin K-dependent protein Z 7.6 0.5 6

Reticulon-1 6.7 1 Vitronectin 9.5 0.4 7

Ig kappa chain V-II region RPMI 6410 6.7 1 Voltage-dependent anion-selective channel protein 1 7.3 1

Serpin B3/B4 6.7 1 Voltage-dependent anion-selective channel protein 2 8.4 0.2 2

Rho-associated protein kinase 1 6.7 1 Voltage-gated potassium channel subunit b-2 6.8 0.7 2

Phosphatidylinositol-binding clathrin assembly protein 6.6 1 von Willebrand factor 8.2 0.3 7

Erlin-1 6.6 1 V-type proton ATPase catalytic subunit A 7.6 0.5 5

Dihydropyrimidinase-related protein 1 6.6 1 V-type proton ATPase subunit B, brain isoform 7.1 0.5 5

Serine/threonine-protein kinase 4 6.6 1 V-type proton ATPase subunit C 1 6.5 0.8 2

Prohibitin 6.6 1 V-type proton ATPase subunit E 1 7.5 1

Rho-related GTP-binding protein RhoG 6.6 1 V-type proton ATPase subunit G 1 7.7 0.9 3

26S protease regulatory subunit 10B 6.6 1 WAP four-disulfide core domain protein 3 9.1 0.3 7

26S proteasome non-ATPase regulatory subunit 8 6.6 1 WD repeat-containing protein 1 7.8 0.4 7

Cytochrome b-245 light chain 6.6 1 Wiskott-Aldrich syndrome protein 6.5 0.0 2

Cytochrome P450 4X1 6.5 1 Wiskott-Aldrich syndrome protein family member 2 7.2 1

N(4)-(beta-N-acetylglucosaminyl)-L-asparaginase 6.5 1 WW domain-binding protein 2 6.8 0.4 5

Tumor-associated calcium signal transducer 2 6.5 1 Xaa-Pro dipeptidase 7.3 0.4 7

RAS protein activator like-3 6.5 1 X-ray repair cross-complementing protein 5 6.9 0.4 4

3-ketoacyl-CoA thiolase, mitochondrial 6.5 1 X-ray repair cross-complementing protein 6 7.2 0.3 5

Phosphatidylinositol transfer protein b isoform 6.5 1 Zinc-alpha-2-glycoprotein 10.0 0.3 7

Nitric oxide synthase, inducible 6.5 1 Zyxin 6.8 0.5 4

Dihydropteridine reductase 6.5 1 1,4-alpha-glucan-branching enzyme 7.1 0.8 7

Receptor-type tyrosine-protein phosphatase eta 6.5 1 10 kDa heat shock protein, mitochondrial 7.4 0.1 2

CTP synthase 1 6.5 1 14-3-3 protein a/b 8.2 0.7 7

Eukaryotic translation initiation factor 3 subunit J 6.4 1 14-3-3 protein epsilon 8.4 0.5 7

N-formyl peptide receptor 2 6.4 1 14-3-3 protein eta 7.2 0.9 6

Unconventional myosin-XVIIIa 6.4 1 14-3-3 protein gamma 7.8 0.6 6

Ragulator complex protein LAMTOR3 6.4 1 14-3-3 protein sigma 7.2 0.3 6

Small ubiquitin-related modifier 1 6.4 1 14-3-3 protein theta 7.1 0.6 6

Protein canopy homolog 3 6.4 1 14-3-3 protein z/d 9.1 0.6 7

Hydroxyacylglutathione hydrolase, mitochondrial 6.3 1 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase b-2 6.0 0.6 2

Alpha/beta-soluble NSF attachment protein 6.3 1 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase g-2 7.2 0.5 3

Echinoderm microtubule-associated protein-like 4 6.3 1 2,3-cyclic-nucleotide 3-phosphodiesterase 7.5 0.4 2

Ubiquitin-like-conjugating enzyme ATG3 6.3 1 26S protease regulatory subunit 10B 6.6 1

Tripeptidyl-peptidase 1 6.3 1 26S protease regulatory subunit 6A 6.8 1

Stress-70 protein, mitochondrial 6.2 1 26S protease regulatory subunit 7 7.0 0.3 2

Alpha-endosulfine 6.1 1 26S proteasome non-ATPase regulatory subunit 2 7.2 0.2 3

Coiled-coil domain-containing protein 150 6.1 1 26S proteasome non-ATPase regulatory subunit 5 6.7 0.4 2

Interleukin-16/Pro-interleukin-16 6.0 1 26S proteasome non-ATPase regulatory subunit 6 6.9 1

High affinity immunoglobulin epsilon receptor subunit g 6.0 1 26S proteasome non-ATPase regulatory subunit 8 6.6 1

UDP-glucose:glycoprotein glucosyltransferase 1 5.9 1 26S proteasome non-ATPase regulatory subunit 9 6.7 0.5 4

Nicastrin 5.9 1 3-ketoacyl-CoA thiolase, mitochondrial 6.5 1

NADP-dependent malic enzyme 5.9 1 3-mercaptopyruvate sulfurtransferase 6.2 0.8 3

Kinesin-1 heavy chain 5.9 1 4F2 cell-surface antigen heavy chain 6.8 0.5 6

Cysteine-rich secretory protein 3 5.8 1 4-trimethylaminobutyraldehyde dehydrogenase 6.7 1

Cullin-4B 5.7 1 55 kDa erythrocyte membrane protein 7.7 0.5 7

Charged multivesicular body protein 4b 5.6 1 60 kDa heat shock protein, mitochondrial 6.1 0.5 3

Cytoskeleton-associated protein 4 5.6 1 60 kDa SS-A/Ro ribonucleoprotein 7.0 0.4 3

PEST proteolytic signal-containing nuclear protein 5.5 1 60S acidic ribosomal protein P1 7.2 0.4 4

Fascin 5.4 1 60S acidic ribosomal protein P2 7.2 0.3 2

Elongation factor Tu, mitochondrial 5.4 1 6-phosphogluconate dehydrogenase 8.9 0.6 7

MAP7 domain-containing protein 1 5.3 1 6-phosphogluconolactonase 7.5 0.7 7

Gamma-synuclein 5.1 1 72 kDa type IV collagenase 7.2 0.5 5

Prothymosin alpha 4.9 1 78 kDa glucose-regulated protein 8.2 0.4 7 Supplemental table 5: Statistical comparison of protein levels in brain abscesses and empyemas. Proteins from the extracellular phase of pus from 20 brain abscesses and 7 subdural empyemas were analyzed by mass spectrometry. Proteins (214) that were detected in all 20 brain abscesses and all 7 empyemas were compared statistically with respect to abundance, using the Student's t-test after z-score normalization of the data, giving 155 proteins as significantly different in the two pus types. Data are log-10 transformations of the raw MS intensity data (mean and SD values). Asterisks indicate that abscess values exceed those of empyemas: *: p < 0.05; **: p< 0.01; ***: p<0.001. # indicates that empyema values exceed those of abscesses; #: p < 0.05; ##: p < 0.01; ###: p<0.001.

Brain abscess Empyema Proteins Mean SD Mean SD P value

Protein S100 -A9 11.5 0.3 10.8 0.5 *** Protein S100-A8 10.8 0.2 10.2 0.5 *** Myeloperoxidase 10.8 0.4 9.6 0.7 *** Lactotransferrin 10.5 0.3 9.6 0.8 *** Plastin-2 10.5 0.3 9.8 0.5 *** Catalase 10.2 0.3 9.6 0.5 *** Myosin-9 10.2 0.4 9.1 0.8 *** Alpha-actinin-1 9.9 0.3 8.9 0.5 *** Neutrophil gelatinase-associated lipocalin 9.8 0.3 8.7 0.7 *** Glucose-6-phosphate isomerase 9.7 0.4 8.7 0.6 *** Transketolase 9.7 0.3 8.7 0.5 *** Filamin-A 9.7 0.4 9.0 0.4 *** Myeloblastin 9.7 0.5 8.8 0.5 *** Leukocyte elastase inhibitor 9.6 0.3 8.9 0.5 *** Ferritin heavy chain 9.5 0.4 8.3 1.0 *** Triosephosphate isomerase 9.5 0.5 8.6 0.7 *** Protein S100-A12 9.5 0.3 8.7 0.5 ***

Ferritin light chain 9.5 0.3 8.5 0.6 *** Transaldolase 9.4 0.4 8.4 0.6 *** Azurocidin 9.4 0.4 8.6 0.8 *** Adenylyl cyclase-associated protein 1 9.3 0.3 8.7 0.4 *** Histone H3 9.3 0.5 8.3 0.7 *** Calmodulin 9.2 0.5 7.7 0.6 *** Vinculin 9.2 0.4 7.8 0.8 *** Fructose-bisphosphate aldolase A 9.2 0.4 8.1 1.1 *** Ubiquitin-60S ribosomal protein L40 9.1 0.4 7.7 1.0 *** Profilin-1 9.0 0.5 8.2 0.4 *** Hemoglobin subunit alpha (HBA2) 9.0 0.4 8.1 0.7 *** Alpha-actinin-4 8.9 0.4 8.2 0.5 *** DNA primase large subunit 8.9 0.5 7.9 0.7 *** Protein S100-P 8.9 0.5 7.9 0.7 *** Talin-1 8.9 0.6 7.8 0.5 *** Coronin-1A 8.8 0.6 7.6 0.6 *** Annexin A3 8.7 0.5 7.8 0.6 *** Myosin light polypeptide 6 8.7 0.5 7.7 0.6 *** Matrix metalloproteinase-9 8.7 0.4 7.9 0.5 *** Carcinoembryonic antigen-related cell adhesion molecule 8 8.6 0.3 7.8 0.5 *** Serpin B10 8.5 0.6 7.3 0.8 *** Thioredoxin 8.5 0.3 7.7 0.4 *** Heat shock 70 kDa protein 1A/1B 8.5 0.3 7.5 0.4 *** Purine nucleoside phosphorylase 8.4 0.3 7.4 0.5 *** Superoxide dismutase [Mn], mitochondrial 8.2 0.5 7.1 0.6 *** Ras GTPase-activating-like protein IQGAP1 8.1 0.3 7.5 0.5 *** Neutrophil collagenase 10.1 0.4 9.2 0.9 ** Spectrin alpha chain, non-erythrocytic 1 9.8 0.5 9.0 0.6 ** Glycogen phosphorylase, liver form 9.8 0.4 9.1 0.6 ** Cathepsin G 9.7 0.8 8.5 1.2 **

Bactericidal permeability-increasing protein 9.5 0.3 8.9 0.5 ** Peroxiredoxin-2 9.5 0.6 8.7 0.5 ** Lysosome-associated membrane glycoprotein 2 9.4 0.8 8.4 0.6 ** Proteasome subunit a type-7 9.4 0.4 8.6 1.0 ** Protein S100-A4 9.4 0.5 8.5 1.0 ** Proteasome subunit a type-1 9.2 0.4 8.7 0.4 ** Heat shock cognate 71 kDa protein 9.2 0.6 8.5 0.5 ** Proteasome subunit a type-5 9.2 0.5 8.4 0.5 ** Actin-related protein 2/3 complex subunit 2 9.1 0.5 8.1 0.8 ** Lysozyme C 9.0 0.7 8.0 1.1 ** Protein S100-A11 8.9 0.5 7.9 0.9 ** Malate dehydrogenase, cytoplasmic 8.9 0.4 8.3 0.4 ** Aminopeptidase N 8.8 0.5 8.1 0.4 ** Glutathione S-transferase omega-1 8.7 0.5 8.0 0.7 ** Proteasome subunit b type-2 8.5 0.6 7.7 0.7 ** 78 kDa glucose-regulated protein 8.4 0.5 7.7 0.6 ** Non-secretory ribonuclease 8.4 0.6 7.5 0.8 ** Glutathione reductase, mitochondrial 7.8 0.5 7.2 0.3 ** Resistin 7.8 0.7 6.5 1.1 ** Actin-related protein 2 9.7 0.4 9.3 0.4 * SH3 domain-binding glutamic acid-rich-like protein 3 9.5 0.4 8.8 0.9 * F-actin-capping protein subunit b 9.5 0.3 9.2 0.4 * Lamin-B1 9.3 0.7 8.4 1.1 * Macrophage-capping protein 9.3 0.6 8.5 1.1 * Neutrophil elastase 9.2 0.6 8.6 0.6 * SH3 domain-binding glutamic acid-rich-like protein 9.1 0.5 8.3 1.1 * Apoptosis-associated speck-like protein containing a CARD 9.0 0.7 8.4 0.5 * Uncharacterized protein KIAA1328 9.0 0.4 8.4 0.5 * Fumarylacetoacetase 8.9 0.5 8.2 0.9 * Peptidyl-prolyl cis-trans isomerase FKBP1A 8.9 0.6 8.2 0.7 *

Puromycin-sensitive aminopeptidase 8.8 0.6 8.1 0.7 * Glutathione synthetase 8.8 0.6 8.2 0.4 * Proteasome subunit a type-4 8.7 0.6 8.1 0.7 * Grancalcin 8.7 0.6 8.1 0.6 * Coactosin-like protein 8.7 0.4 8.2 0.6 * ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 2 8.7 0.7 7.8 1.0 * Actin-related protein 2/3 complex subunit 3 8.6 0.6 7.9 0.7 * Glutaredoxin-1 8.5 0.6 7.9 0.8 * Galectin-10 8.4 0.6 7.9 0.5 * Serpin B6 8.4 0.7 7.7 0.8 * Peptidyl-prolyl cis-trans isomerase B 8.4 0.6 7.7 0.4 * Adenosine deaminase 8.3 0.5 7.7 0.7 * Glyoxalase domain-containing protein 4 8.2 0.6 7.6 0.5 * Actin-related protein 2/3 complex subunit 1B 8.1 0.6 7.5 0.6 * Acid ceramidase 8.1 0.5 7.5 0.6 * Heterogeneous nuclear ribonucleoprotein A1 8.0 0.7 7.3 0.7 * Ceruloplasmin 10.6 0.3 11.1 0.2 ### Fibronectin 10.3 0.4 10.9 0.3 ### Zinc-alpha-2-glycoprotein 10.2 0.4 11.1 0.2 ### Leucine-rich alpha-2-glycoprotein 10.1 0.6 11.0 0.1 ### Alpha-1-acid glycoprotein 2 10.0 0.5 10.8 0.2 ### Ig kappa chain V-I region BAN 9.6 0.5 10.4 0.4 ### Versican core protein 9.5 0.7 10.6 0.3 ### Ig lambda chain V-III region SH 9.4 0.6 10.3 0.3 ### Alpha-1-antichymotrypsin 9.4 0.4 9.9 0.2 ### Complement C3 9.3 0.7 10.6 0.3 ### Ig lambda-2 chain C regions 9.3 1.1 11.2 0.2 ### Ig gamma-1 chain C region 9.3 0.5 10.2 0.2 ### Apolipoprotein D 9.2 0.6 10.2 0.3 ### Vitamin D-binding protein 9.1 0.7 10.4 0.3 ###

Ig alpha-1 chain C region 9.1 0.4 10.1 0.2 ### Complement C4-B 9.1 0.6 10.4 0.4 ### Alpha-1-antitrypsin 9.0 0.6 10.3 0.4 ### Ig lambda-1 chain C regions 8.9 0.3 9.5 0.3 ### Ig gamma-2 chain C region 8.9 0.5 9.7 0.4 ### Plasma kallikrein 8.8 0.5 9.8 0.5 ### Alpha-1B-glycoprotein 8.7 0.3 9.5 0.1 ### Inter-alpha-trypsin-inhibitor heavy chain H4 8.6 0.6 9.5 0.4 ### Alpha-2-antiplasmin 8.5 0.5 10.2 0.5 ### Ig kappa chain V-III region NG9 8.5 0.4 9.5 0.4 ### Ig kappa chain V-I region Roy 8.4 0.8 10.1 0.3 ### Ig heavy chain V-III region TIL 8.3 0.4 9.5 0.3 ### Ig gamma-3 chain C region 8.3 1.1 9.9 0.1 ### Alpha-2-HS-glycoprotein 8.3 0.6 9.7 0.3 ### Ig heavy chain V-III region BRO 8.2 0.5 9.2 0.2 ### Ig kappa chain V-III region SIE 8.1 0.6 9.3 0.3 ### Complement factor B 8.0 0.5 8.9 0.2 ### Complement factor I 7.8 0.9 9.8 0.4 ### Carbonic anhydrase 2 7.7 0.5 9.1 0.4 ### Vitronectin 7.7 0.8 9.8 0.1 ### Corticosteroid-binding globulin 7.6 0.6 8.8 0.2 ### Alpha-2-macroglobulin 11.4 0.4 11.9 0.1 ## WAP four-disulfide core domain protein 3 10.5 0.3 10.9 0.2 ## Plasma protease C1 inhibitor 10.0 0.3 10.5 0.2 ## Antithrombin-III 9.8 0.3 10.2 0.2 ## Hemopexin 9.4 0.3 9.9 0.3 ## Serum albumin 9.4 0.5 10.0 0.3 ## Fibrinogen a chain 9.3 0.3 9.7 0.3 ## Serotransferrin 9.1 0.7 9.9 0.3 ## Apolipoprotein A-I 8.9 0.3 9.3 0.2 ##

Ig kappa chain V-IV region Len 8.8 0.4 9.3 0.3 ## Apolipoprotein A-II 8.7 0.4 9.3 0.3 ## Ig lambda chain V-I region WAH 8.4 0.5 9.1 0.3 ## Ig lambda variable 3-21 8.4 0.4 8.9 0.2 ## Apolipoprotein B-100 8.0 0.6 8.7 0.3 ## Fibrinogen gamma chain 7.6 0.7 8.5 0.2 ## Fibrinogen beta chain 10.4 0.3 10.7 0.2 # Ig heavy chain V-III region KOL 9.7 0.5 10.1 0.2 # Ig kappa chain C region 9.5 0.5 10.0 0.3 # Ig lambda chain V-III region LOI 9.0 0.7 9.8 0.7 # Kallistatin 8.8 0.6 9.3 0.2 # Ig kappa chain V-III region B6 8.6 0.6 9.2 0.3 # Fatty acid-binding protein, epidermal 8.5 0.5 9.0 0.4 # Ig mu chain C region 8.1 0.5 8.5 0.4 # C4b-binding protein alpha chain 8.0 0.5 8.6 0.4 # Ig lambda chain V-II region NIG-84 8.0 0.4 8.3 0.2 # Inter-alpha-trypsin inhibitor heavy chain H1 7.9 0.3 8.3 0.3 # Serum amyloid P-component 7.9 0.6 8.6 0.8 #