Additional information #1. Genes with a statistically different expression as a result of exposure to bleomycin, analyzed in 14 lymphoblastoid cell lines

Gene Description p-value GenBank Accession

Increased expression by bleo treatment CAMK1 Calcium/calmodulin-dependent protein kinase I 0.001 NM_003656 CDKN1A Cyclin-dependent kinase inhibitor 1A (p21, Cip1) 0.001 U03106 XPC Xeroderma pigmentosum, complementation group C 0.001 NM_004628 H2AFZ H2A histone family, member Z 0.001 NM_002106 POLH Polymerase (DNA directed), eta 0.001 NM_006502 FDXR Ferredoxin reductase 0.001 NM_004110 RGS16 Regulator of G-protein signalling 16 0.001 NM_002928 FRDA Frataxin 0.001 NM_000144 TNFSF7 Tumor necrosis factor (ligand) superfamily, member 7 0.001 NM_001252 TNFSF9 Tumor necrosis factor (ligand) superfamily, member 9 0.001 NM_003811 UBR1 Ubiquitin protein ligase E3 component n-recognin 1 0.001 AF061556 BBC3 BCL2 binding component 3 0.001 U82987 CD37 CD37 antigen 0.001 NM_001774 ANKFY1 Ankyrin repeat and FYVE domain containing 1 0.001 NM_016376 CX3CL1 Chemokine (C-C motif) ligand 22 0.001 NM_002990 PPM1D Protein phosphatase 1D magnesium-dependent, delta isoform 0.001 NM_003620 COL4A4 Collagen, type IV, alpha 4 0.002 NM_000092 DDB2 Damage-specific DNA binding protein 2, 48kDa 0.002 NM_000107 TKTL1 Transketolase-like 1 0.002 NM_012253 RABL4 RAB, member of RAS oncogene family-like 4 0.002 NM_006860 SLMAP Sarcolemma associated protein 0.002 NM_007159 GKAP1 G kinase anchoring protein 1 0.002 AF319476 TNFSF14 Tumor necrosis factor (ligand) superfamily, member 14 0.002 NM_003807 HIRIP3 HIRA interacting protein 3 0.002 NM_003609 KIF3B Kinesin family member 3B 0.002 NM_004798 PLK3 Polo-like kinase 3 (Drosophila) 0.002 NM_004073 ITIH2 Inter-alpha (globulin) inhibitor H2 0.002 NM_002216 SERPINA4 Serine (or cysteine) proteinase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 4 0.002 NM_006215 MYL3 Myosin, light polypeptide 3, alkali; ventricular, skeletal, slow 0.002 NM_000258 ATP5B ATP synthase, H+ transporting, mitochondrial F1 complex, beta polypeptide 0.003 NM_001686 GNLY Granulysin 0.003 NM_012483 DRP2 Dystrophin related protein 2 0.003 NM_001939 GRID2 Glutamate receptor, ionotropic, delta 2 0.003 NM_001510 SGSH N-sulfoglucosamine sulfohydrolase (sulfamidase) 0.003 NM_000199 UCN Urocortin 0.003 NM_003353 PGLS 6-phosphogluconolactonase 0.003 NM_012088 PHKG2 Phosphorylase kinase, gamma 2 (testis) 0.003 NM_000294 SLC25A5 Solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 5 0.003 L32786 ARID3A AT rich interactive domain 3A (BRIGHT- like) 0.003 NM_005224 TITF1 Hypothetical protein LOC253970 0.003 AK027147 IL27RA Interleukin 27 receptor, alpha 0.003 NM_004843 PGS1 Phosphatidylglycerophosphate synthase 0.004 AL359590 GP9 Glycoprotein IX (platelet) 0.004 NM_000174 DPP4 Dipeptidylpeptidase 4 (CD26, adenosine deaminase complexing protein 2) 0.004 NM_001935 HSD11B2 Hydroxysteroid (11-beta) dehydrogenase 2 0.004 NM_000196 METTL1 Methyltransferase like1 0.004 Y18643 DNAH7 Dynein, axonemal, heavy polypeptide 7 0.004 AJ132084 SNAP25 Synaptosomal-associated protein, 25kDa 0.004 NM_003081 HSD3B2 Hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2 0.004 NM_000198 SPPL2B Signal peptide peptidase-like 2B 0.004 AB040965 PLG Plasminogen 0.004 NM_000301 RHOBTB1 Rho-related BTB domain containing 1 0.004 AB018283 AR Androgen receptor 0.004 L29496

Decreased expression by bleomycin treatment PIP5K1A Phosphatidylinositol-4-phosphate 5-kinase, type I, alpha 0.001 NM_003557 ACSL1 Acyl-CoA synthetase long-chain family member 1 0.001 NM_001995 TPX2 TPX2, microtubule-associated protein homolog (Xenopus laevis) 0.001 AB024704 BST2 Bone marrow stromal cell antigen 2 0.001 NM_004335 PPP3CB Protein phosphatase 3 (formerly 2B), catalytic subunit, beta isoform (calcineurin A beta) 0.001 M29551 CSNK2A1 Casein kinase 2, alpha 1 polypeptide 0.001 NM_001895 CD53 CD53 antigen 0.001 M37033 CENPA Centromere protein A, 17kDa 0.001 NM_001809 CCNB2 Cyclin B2 0.001 NM_004701 ZNF410 Zinc finger protein 410 0.001 U90919 DCTN2 Dynactin 2 (p50) 0.001 NM_006400 TLP19 Endoplasmic reticulum thioredoxin superfamily member, 18 kDa 0.001 NM_015913 LTA4H Leukotriene A4 hydrolase 0.001 NM_000895 CCNA2 Cyclin A2 0.001 NM_001237 TUBA6 Tubulin alpha 6 0.001 D28390 CECR5 Cat eye syndrome chromosome region, candidate 5 0.001 NM_017829 FKBP4 FK506 binding protein 4, 59kDa 0.001 NM_002014 KNTC2 Kinetochore associated 2 0.001 NM_006101 LAPTM4A Lysosomal-associated protein transmembrane 4 alpha 0.001 NM_014713 TM9SF1 Transmembrane 9 superfamily member 1 0.001 NM_006405 MORF4L2 Mortality factor 4 like 2 0.001 NM_012286 ELAVL1 ELAV (embryonic lethal, abnormal vision, Drosophila)-like 1 (Hu antigen R) 0.001 NM_001419 MRPS17 Mitochondrial ribosomal protein S17 0.001 NM_015969 PLK1 Polo-like kinase 1 (Drosophila) 0.001 NM_005030 CDC25B Cell division cycle 25B 0.001 NM_004358 RAC1 Ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1) 0.001 D25274 RAMP RA-regulated nuclear matrix-associated protein 0.001 NM_016448 SSR2 Signal sequence receptor, beta (translocon-associated protein beta) 0.001 NM_003145 TM9SF2 Transmembrane 9 superfamily member 2 0.001 NM_004800 DERP6 S-phase 2 protein 0.001 NM_015362 SF1 Splicing factor 1 0.001 NM_004630 SIAH2 Seven in absentia homolog 2 (Drosophila) 0.001 NM_005067 XBP1 X-box binding protein 1 0.001 NM_005080 EIF4G2 Eukaryotic translation initiation factor 4 gamma, 2 0.001 NM_001418 ADAMTS9 A disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 9 0.001 NM_020249 NEDD8 Neural precursor cell expressed, developmentally down-regulated 8 0.001 NM_006156 UBE2G1 Ubiquitin-conjugating enzyme E2G 1 (UBC7 homolog, C. elegans) 0.001 D78514 TIMM10 Translocase of inner mitochondrial membrane 10 homolog (yeast) 0.001 NM_012456 CCT8 Chaperonin containing TCP1, subunit 8 (theta) 0.002 NM_006585 HSPA8 Heat shock 70kDa protein 8 0.002 NM_006597 BCAP29 B-cell receptor-associated protein 29 0.002 NM_018844 CALU Calumenin 0.002 NM_001219 NALP1 NACHT, leucine rich repeat and PYD (pyrin domain) containing 1 0.002 NM_014922 RGC32 Response gene to complement 32 0.002 NM_014059 CLIC4 Chloride intracellular channel 4 0.002 NM_013943 CDK4 Cyclin-dependent kinase 4 0.002 NM_000075 DCTD DCMP deaminase 0.002 NM_001921 DAP3 Death associated protein 3 0.002 NM_004632 DLD Dihydrolipoamide dehydrogenase 0.002 NM_000108 PSAP Prosaposin (variant Gaucher disease and variant metachromatic leukodystrophy) 0.002 J03077 GEMIN6 Gem (nuclear organelle) associated protein 6 0.002 AK027112 GOT1 Glutamic-oxaloacetic transaminase 1, soluble (aspartate aminotransferase 1) 0.002 NM_002079 GARS Glycyl-tRNA synthetase 0.002 NM_002047 TUBB1 Tubulin, beta 1 0.002 AJ292757 ARF3 ADP-ribosylation factor 3 0.002 NM_001659 RHEB Ras homolog enriched in brain 0.002 NM_005614 MTHFD1 Methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1, 0.002 NM_005956 DHX35 DEAH (Asp-Glu-Ala-His) box polypeptide 35 0.002 AK026412 MLC1 Megalencephalic leukoencephalopathy with subcortical cysts 1 0.002 D25217 IDH3B Isocitrate dehydrogenase 3 (NAD+) beta 0.002 NM_006899 ED1 Ectodysplasin A 0.002 NM_001399 MAPRE1 Microtubule-associated protein, RP/EB family, member 1 0.002 NM_012325 MRPL37 Mitochondrial ribosomal protein L37 0.002 NM_016491 MLLT3 Myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3 0.002 NM_004529 NUP93 Nucleoporin 93kDa 0.002 NM_014669 SLC29A2 Solute carrier family 29 (nucleoside transporters), member 2 0.002 AF034102 OLFM1 Olfactomedin 1 0.002 U79299 FLJ20399 DEAD (Asp-Glu-Ala-Asp) box polypeptide 28 0.002 NM_018380 PRDX1 Peroxiredoxin 1 0.002 NM_002574 CUL7 Cullin 7 0.002 NM_014780 MID1 Midline 1 (Opitz/BBB syndrome) 0.002 NM_000381 DUSP12 Dual specificity phosphatase 12 0.002 NM_007240 RAB2 RAB2, member RAS oncogene family 0.002 NM_002865 RAD21 RAD21 homolog (S. pombe) 0.002 NM_006265 TRA2A Transformer-2 alpha 0.002 NM_013293 CBFB Core-binding factor, beta subunit 0.002 AF294326 GRB7 Growth factor receptor-bound protein 7 0.002 NM_005310 RNUT1 RNA, U transporter 1 0.002 NM_005701 SKP1A S-phase kinase-associated protein 1A (p19A) 0.002 D17032 AF5Q31 ALL1 fused gene from 5q31 0.002 NM_014423 EIF4A1 CD68 antigen 0.002 D17188 RFP Ret finger protein 0.002 NM_006510 TPD52 Tumor protein D52 0.002 NM_005079 CUL2 Cullin 2 0.002 NM_003591 ZNF330 Zinc finger protein 330 0.002 NM_014487 AK3L1 Adenylate kinase 3 0.003 NM_016282 MGAT2 Mannosyl (alpha-1,6-)-glycoprotein beta-1,2-N-acetylglucosaminyltransferase 0.003 NM_002408 SLC38A2 Solute carrier family 38, member 2 0.003 NM_018976 ANXA2 Annexin A2 0.003 NM_004039 BAT1 HLA-B associated transcript 1 0.003 NM_004640 FADD Fas (TNFRSF6)-associated via death domain 0.003 NM_003824 SSA1 Tripartite motif-containing 21 0.003 NM_003141 PRKRA Protein kinase, interferon-inducible double stranded RNA dependent activator 0.003 NM_003690 EXO1 Exonuclease 1 0.003 NM_003686 XPO6 Exportin 6 0.003 AB002368 ATP6V1E1 ATPase, H+ transporting, lysosomal 31kDa, V1 subunit E isoform 1 0.003 NM_001696 PGAM1 Phosphoglycerate mutase 1 (brain) 0.003 NM_002629 NUP54 Nucleoporin 54kDa 0.003 NM_017426 OAZIN Antizyme inhibitor 1 0.003 NM_015878 OGDHL Oxoglutarate dehydrogenase-like 0.003 NM_018245 HPRP8BP WD repeat domain 57 (U5 snRNP specific) 0.003 NM_004814 PHB Prohibitin 0.003 NM_002634 TRAPPC4 Trafficking protein particle complex 4 0.003 NM_016146 COPZ1 Coatomer protein complex, subunit zeta 1 0.003 NM_016057 SNX1 Sorting nexin 1 0.003 NM_003099 RAF1 V-raf-1 murine leukemia viral oncogene homolog 1 0.003 NM_002880 PPP1CB Protein phosphatase 1, catalytic subunit, beta isoform 0.003 NM_002709 PR48 Protein phosphatase 2 (formerly 2A), regulatory subunit B'', beta 0.003 NM_013239 AURKB Aurora kinase B 0.003 NM_004217 CRKL V-crk sarcoma virus CT10 oncogene homolog (avian)-like 0.003 AK000311 DKFZp566C0424 Putative MAPK activating protein PM20,PM21 0.003 AL050028 RAP1B RAP1B, member of RAS oncogene family 0.003 X08004 COPS4 COP9 constitutive photomorphogenic homolog subunit 4 (Arabidopsis) 0.003 NM_016129 STRAP 2-deoxyribose-5-phosphate aldolase homolog (C. elegans) 0.003 NM_015954 STAG3 Stromal antigen 3 0.003 NM_012447 SDHB Succinate dehydrogenase complex, subunit B, iron sulfur (Ip) 0.003 NM_003000 TEGT Testis enhanced gene transcript (BAX inhibitor 1) 0.003 NM_003217 TTRAP TRAF and TNF receptor associated protein 0.003 NM_016614 YY1 Solute carrier family 25, member 29 0.003 AK026497 DDX1 DEAD (Asp-Glu-Ala-Asp) box polypeptide 1 0.003 NM_004939 TIMM17A Translocase of inner mitochondrial membrane 17 homolog A (yeast) 0.003 NM_006335 TUBB2 Tubulin, beta, 2 0.003 NM_006088 C14orf130 Chromosome 14 open reading frame 130 0.003 NM_018108 VAPB VAMP (vesicle-associated membrane protein)-associated protein B and C 0.003 NM_004738 RABEP1 Rabaptin, RAB GTPase binding effector protein 1 0.003 NM_004703 AACS Acetoacetyl-CoA synthetase 0.004 AK022451 HADHB Hydroxyacyl-Coenzyme A dehydrogenase 0.004 NM_000183 ANP32B Acidic (leucine-rich) nuclear phosphoprotein 32 family, member B 0.004 NM_006401 ABCB10 ATP-binding cassette, sub-family B (MDR/TAP), member 10 0.004 NM_012089 VCP Valosin-containing protein 0.004 NM_007126 ACLY ATP citrate lyase 0.004 NM_001096 CASC3 Cancer susceptibility candidate 3 0.004 NM_007359 CSNK2A2 Casein kinase 2, alpha prime polypeptide 0.004 NM_001896 CGREF1 Cell growth regulator with EF hand domain 1 0.004 NM_006569 ARPC4 Actin related protein 2/3 complex, subunit 4, 20kDa 0.004 NM_005718 LIG3 Ligase III, DNA, ATP-dependent 0.004 NM_013975 SEC63 SEC63-like (S. cerevisiae) 0.004 NM_007214 SLC2A1 Solute carrier family 2 (facilitated glucose transporter), member 1 0.004 NM_006516 GOLGA3 Golgi autoantigen, golgin subfamily a, 3 0.004 NM_005895 ITPK1 Inositol 1,3,4-triphosphate 5/6 kinase 0.004 NM_014216 ITPR1 Inositol 1,4,5-triphosphate receptor, type 1 0.004 D26070 LBR Lamin B receptor 0.004 NM_002296 MK-STYX Dual specificity phosphatase 24 (putative) 0.004 NM_016086 MARS Methionine-tRNA synthetase 0.004 NM_004990 HOMER1 Homer homolog 1 (Drosophila) 0.004 NM_004272 PTEN Phosphatase and tensin homolog (mutated in multiple advanced cancers 1) 0.004 AK024986 PTP4A2 Protein tyrosine phosphatase type IVA, member 2 0.004 NM_003479 RBBP6 Retinoblastoma binding protein 6 0.004 NM_006910 RAE1 RAE1 RNA export 1 homolog (S. pombe) 0.004 NM_003610 SIAT1 ST6 beta-galactosamide alpha-2,6-sialyltranferase 1 0.004 NM_003032 GEMIN4 Gem (nuclear organelle) associated protein 4 0.004 NM_015721 M6PR Mannose-6-phosphate receptor (cation dependent) 0.004 NM_002355 UQCRFS1 Ubiquinol-cytochrome c reductase, Rieske iron-sulfur polypeptide 1 0.004 NM_006003