Typhoid conjugate vaccine introduction cost to countries and support from Gavi, the Vaccine Alliance The World Health Organization recommends TCV introduction for infants and children over 6 months of age as a single dose, and where feasible, a single dose catch-up of children up to 15 years of age.

ROUTINE IMMUNIZATION CAMPAIGN

TARGET POPULATION 6 to 15 months old* 9 months to 15 years old

VACCINE PRICE PER DOSE $1.50 $1.50 COST TO COUNTRY Co-financing based on transition phase Initial Preparatory Accelerated Fully VACCINE PRICE self-financing transition transition self-financing $ 0 PER DOSE Based on Based on Vaccine procurement TO THE COUNTRY country country fully supported by Gavi $0.20 specific price specific price $1.50 fraction fraction PAID BY GAVI Vaccine Introduction Grant (VIG) Operational support for campaigns (Ops) Dependent on country transition phase Dependent on country transition phase

Initial Preparatory Accelerated Initial Preparatory Accelerated PROGRAMMATIC self-financing transition transition self-financing transition transition SUPPORT FROM GAVI $0.80 $0.70 $0.60 per infant in the birth per infant in the birth per infant in the birth cohort in year of cohort in year of cohort in year of $0.65 $0.55 $0.45 introduction, or a lump introduction, or a lump introduction, or a lump per targeted person per targeted person per targeted person sum of US$100,000, sum of US$100,000, sum of US$100,000, whichever is higher whichever is higher whichever is higher

* In some instances, an older child may be vaccinated during a routine immunization visit if vaccination between 6 and 15 months is missed. All costs are in US dollars. Source: Gavi, Application guidelines: Gavi’s support to countries. Available at www.gavi.org/support/process/apply/

Typhoid Vaccine Acceleration Consortium TyVAC a program of the CENTER FOR VACCINE DEVELOPMENT OXFORD VACCINE GROUP PATH • • Sabin Vaccine Institute