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The 1st Symposium of Inventions and Innovations – Medicine 2040 (INI): Rewriting the Future of Healthcare Tel Aviv, , November 4-5, 2019

November 4, 2019

07:30-08:30 Gathering (Exhibition Area)

Hall A Hall B Hall C

07:30-08:30 Free Abstracts Mindfulness with Dr. Tal Agami Chen Varol, Israel, Robert Benamouzig, France, Chairs and TBD

08:30-10:00 Plenary Session 1 | Medicine 2040 Nadir Arber, Israel, Ran Balicer, Israel and Ido Chairs Wolf, Israel Greetings

Medicine 2040: Ronni Gamzu, Israel

Healthcare, transformed: Ran Balicer, Israel The quest to predict the future: Kira Radinsky,

Israel The system for protein degradation: roles in health and in disease: Avram Hershko, Israel, Laureate 10:00-10:30 Coffee Break (Exhibition Area) Session 2 | Fighting smoking: Prevention and 10:30-12:00 Session 3 | Medical Education 2020-2040 Session 4 | Big data and artificial intelligence quitting Neville Berkman, Israel and Yehuda Schwarz, Ehud Grossman, Israel, Gideon Paret, Israel Noam Shomron, Israel, Sol Efroni, Israel, and Chairs Israel and TBD Eitan Rubin, Israel From one generation to the next; how would the Is there a profile of the average smoker? Can we The morning patients round: Intelligent algorithms physician role change: Ran Matot, Israel and Idit actually quit smoking? TBD in decision making: Yishai Ofran, Israel Matot, Israel The urgent need for novel smoking cession TBD: Dina Ben Yehuda, Israel Big data to eliminate HCV? Noa Dagan, Israel medications: Laura Rosen, Israel Fighting smoking in the real world setting: Hiroya TBD: Gideon Paret, Israel AI-driven hospital: Kira Radinsky, Israel Kumamaru, Japan The clinical implications of tertiary medical center: Behavioral therapy: TBD TBD: Rivka Carmi, Israel Ahuva Weiss-Meilik, Israel Drug therapy: TBD The Google perspective: Yossi Matieas, Israel The media position: Adi Leiba, Israel

1 | P a g e Program as of 22.09.2019 - Subject to change

The 1st Symposium of Inventions and Innovations – Medicine 2040 (INI): Rewriting the Future of Healthcare Tel Aviv, Israel, November 4-5, 2019

Educational and legal perspective: TBD

12:00-13:00 Session 5 | Fighting bacterial resistance Session 6 | Predicting the best therapies Session 7 | Curing HIV Ronen Ben Ami, Israel, Amram Mor, Israel and Ravit Geva, Israel, Gary Schwartz, USA and Jürgen Rockstroh, Germany , Itzhak Levi, Israel, Chairs Jacob Strahilevitz, Israel TBD and Michal Chowers, Israel Injectable antiretroviral therapy: Are we going to Bacterial resistance and emerging of new Tumor histology is a must?: Nir Peled, Israel shift the treatment paradigm? Jürgen Rockstroh, infectious diseases: Yehuda Carmeli, Israel Germany Global aspects of our research on novel Heterogeneity and resistance: Salomon Recent advances in HIV-vaccines: What to antibiotics: , Israel, Nobel Prize Stemmer, Israel expect? Ralf Wagner, Germany Laureate Structure based design of novel drugs against Computational and evolutionary methods to The HIV Cure: Georg Behrens, Germany pathogenic bacteria: Giuseppe Cimicata, Israel combat resistance: Jacob Scott, USA Type 6 secretion system and how to utilize it to The Chicken Embryo Model: Shiran Shapira,

benefit human health: Dor Salomon, Israel Israel 13:00-13:20 Appetizers Lunch Symposium | The Djerassi-Elias Lunch Symposium | Cure of hemato-oncology 13:20-14:20 Lunch Symposium | Environmental hazards Institute of Oncology- Technology symposium [Sponsored by Janssen] on cancer [Principle Investigators] Ada Yonath, Israel, Nobel prize laureate , Rina Irit Avivi, Israel and Maya Koren-Michowitz, Avram Hershko, Israel, Nobel prize laureate, Chairs Rosin-Arbesfeld, Israel, Ariel Munitz, Israel, and Israel and Moshe Mittelman, Israel Alfred Neugut, USA and TBD TBD General clinical perspective of environmental Prevention of AML: Liran Shlush, Israel TBD: TBD hazards: Sigal Sadetzski, Israel Personalized treatment in hematology- targeting Perspectives and challenges in environmental tumor cell and their microenviornment: Ido Amit, Short presentations by established investigators hazards: Veronique Ezratty, France Israel Enivornmental hazard – Current and future Cure of CML: Pia Raanani, Israel perspective of the Ministry of Health: Itamar Awards Ceremony Grotto, Israel Chemofree therapies - where are we and where Trends and policy of the Ministry of Enviornmental

will we be? TBD protection: Orna Matzner, Israel Preventing transformation from MGUS into SMM Myths and fake news: Alfred Neugut, USA and MM: TBD 14:20-14:40 Dessert

2 | P a g e Program as of 22.09.2019 - Subject to change

The 1st Symposium of Inventions and Innovations – Medicine 2040 (INI): Rewriting the Future of Healthcare Tel Aviv, Israel, November 4-5, 2019

November 4, 2019

Hall A Hall B Hall C Session 9 | The dark age of single organ 14:40-16:00 Session 8 | Microbiome is everything Session 10 | Cardiology 2040 screening is over Omry Koren, Israel and Nitsan Maharshak, Ofer Merimsky, Israel, Elizabeth Half, Israel, and Ran Kornowski, Israel, Shmuel Banai, Israel and Chairs Israel and TBD Yaron Niv, Israel Chaim Danenberg, Israel Diseases can be cured by manipulating the Revolutionary, rational, and realizable: David Unmet Needs in Cardiovascular Medicine: Present

microbiome: Yehuda Ringel, Israel Ahlquist, USA & Future: Ran Kornowski, Israel Thinking outside the mouse: ex-vivo dissections of The golden aging of methylation and folding: Matt Israel Cardiovascular Innovation: The 'Start Up' host-microbiome cross talks: Nissan Yissachar, Trau, Australia Nation Phenomenon: Chaim Lotan, Israel Israel The Biodesign Innovation/Translaitonal Model in Future of microbiome analysis and bacteriotherapy Progastrin: Alex Prieur, France CV Medicine- From Concept to Implementation: in IBD: Nitsan Maharshak, Israel Leor Perl, Israel The Present and Future of Stem Cell & Genetic The microbiome is overrated: Eran Segal, Israel Hossam’s electronic nose: Hossam Haick, Israel Therapeutics of the Heart: Lior Gepstein, Israel The microbiome is under estimated: Eran Elinav, CD24: Shiran Shapira, Israel Israel 16:00-17:00 Session 11 | Remodeling brain functions Session 12 | Genomic and gene therapy Session 13 | Curing Hepatitis Gideon Rechavi, Israel, Shay Ben-Shachar, Jürgen Rockstroh, Germany , Oren Shibolet, Chairs Uri Ashery, Israel and TBD Israel and Hagit Baris Feldman, Israel Israel and Ziv Ben Ari, Israel Targeting exosome for brain disorders and spinal Gene therapy is here: the hemophilia paradigm: HCV elimination: Eli Zuckerman, Israel cord injury: Dani Offen, Israel Gili Kenet, Israel Engineering the environment for neurons post CRISPR can build and maintain the perfect Cure of HBV: Sanjay Bhagani, UK trauma: Orit Shefi, Israel genome. Severe Combined Immunodeficiency as a proof of concept: Ayal Hendel, Israel Engineering personalized neuronal tissue Gene targeting of chimeric antigen receptors Hepatitis D - Are there new treatment options in

implants: Tal Dvir, Israel (CARs): TBD the horizon? Jeffrey S. Glenn, USA Aging – the most relevant future targeted disease: Paving roads for CARs in Israel: Elad Jacoby,

Shai Efrati, Israel Israel Future dimensions in CARTs: Anat Globerson

Levin, Israel 17:00-17:20 Technical Break

3 | P a g e Program as of 22.09.2019 - Subject to change

The 1st Symposium of Inventions and Innovations – Medicine 2040 (INI): Rewriting the Future of Healthcare Tel Aviv, Israel, November 4-5, 2019

November 4, 2019

Hall A Hall B Hall C

17:20-18:20 Session 14 | Liver on the edge Session 15 | Oncology is not just oncology Session16 | The economy of novel drugs Oren Sibolet, Israel and Danieel Shuval, Israel Pia Raanani, Israel, Michal Laufer Perl, Israel Mati Berkovitch, Israel, Jacob Glazer, Israel and Chairs and Rifaat Safadi, Israel and Baruch Brenner, Israel Reuven Porat, Israel Fatty liver: the cause of all troubles: Shira Zilberg, The ESMO magnitude of clinical benefit ccale and Oncology – cardiology: Zaza Iakobishvili, Israel Israel its global impact: Nathan Cherny, Israel Liver Assist devices - Evidence for, how to use Biosimilars: Are they similar? Are they efficient? Oncology – endocrinology: Esther Osher, Israel and where we might be going: Julia Wendon, UK Mario Dicato, Luxemburg History and future opf primary sclerosing Who should approve them? Mati Berkovitch, Palliative care: Pesach Schwartzman, Israel cholangitis: Tom Hemming Karlsen, Norway Israel Social network among young patients: Irit Ben- The economic burden of modern medicine: Jacob

Aharon, Israel Glazer, Israel

4 | P a g e Program as of 22.09.2019 - Subject to change

The 1st Symposium of Inventions and Innovations – Medicine 2040 (INI): Rewriting the Future of Healthcare Tel Aviv, Israel, November 4-5, 2019

November 5, 2019

Hall A Hall B Hall C

07:30-08:30 Free abstracts Mindfulness with Dr. Tal Agami Jacob Giris, Israel and Julius Špičák, Czech Chairs Republic

08:30-10:00 Plenary Session 17 | Medicine 2040

Chairs Iris Dotan, Israel and TBD TBD: Roger Kornberg, USA, Nobel Prize

Laureate Genetics versus Epigenetic: Where the future will

take us: Gideon Rechavi, Israel Innovations in medicine 2040 – rules and

mistakes: Jaroslaw Regula, Poland The Giants Debate: Mario vs. Yossi: Is cancer a

matter of bad luck? Pro: Mario Dicato, Luxemburg

Con: Yossi Yarden, Israel The best therapy is prevention: Twenty years of

experience of a one stop shop: Nadir Arber, Israel 10:00-10:30 Coffee Break (Exhibition Area) Session 19| Novel Approaches in cancer Session 20 | What would you prefer: A doctor 10:30-12:00 Session 18 | Curing the aging brain therapy or a robot? Eric Vancutsem, Belgium, Baruch Brenner, Joseph Klausner, Israel, Rami Hershkowitz, Chairs Anat Achiron, Israel, and TBD Israel and Abraham Kuten, Israel Israel and Guy Lahat, Israel How will the Blue Brain solve our neurological Introduction: Moshe Shoham, Israel problems? Idan Segev, Israel Cancer 2030: Jacob Schachter, Israel The Blue Brain solution for neurodegenerative The computerized automated medical revolution: Nanomedicine: Alberto Gabizon, Israel diseases: Richard Frackowiak, Switzerland Zamir Halpern, Israel Future therapies in sex impairment: Gila Bronner, Cancer “signature” can prolong life: Dan Aderka, Endoscopist: Ori Segol, Israel Israel Israel Why have we failed in our fight against dementia Personalized Radiation: Javier Torres-Roca, and how are we going to win?!: Amos Korczyn, Surgeon: Ido Nachmany, Israel USA Israel Drug development in a hub: Magnus Bjorsne, Artificial intelligence is a must: Noam Shomron,

Sweden Israel 5 | P a g e Program as of 22.09.2019 - Subject to change

The 1st Symposium of Inventions and Innovations – Medicine 2040 (INI): Rewriting the Future of Healthcare Tel Aviv, Israel, November 4-5, 2019

Choosing Wisely: Ran Balicer, Israel Session 22 | To renovate or innovate – the Session 23 | Will doctors still be needed in 12:00-13:00 Session 21 | A taste of the future hospital CEO dilemma 2040? It is in the hands of the family physician. Ronit Anbar, Israel, Ronit Endevelt, Israel and Shlomo Vinker, Israel , Shlomo Birkenfeld, Chairs Ronni Gamzu, Israel TBD Israel and Michal Shani, Israel Panel: Rafael Bayer, Israel, Ronni Gamzu, The future plate – taste for Israeli foodtech: Ofir Israel, Michael Halberthal, Israel, Yonatan Telemedicine in primary care: hope or hype? Dror

Benjamin, Israel Halevy, Israel, Zeev Rotstein, Israel, and Eytan Dolfin, Israel Wirtheim, Israel Taste and nutrition, with a little help from big data: How to benefit from artificial intelligence without

Masha Niv, Israel being controlled by it? Aviva Elad, Israel The future of nutritional treatment- challenges and In favor of the teamwork / status quo: Michal

solutions: Ronit Endevelt,Israel Shani, Israel Why are they ignoring our advice? The promise of P-Nutrition - The future strategies of preventive behavioral economics: Adi Berliner Senderey, clinical nutrition: Limor Ben Haim, Israel Israel M- Nutrition - When nutrition is the medicine:

Ronit Anbar, Israel 13:00-13:20 Appetizers Lunch Symposium | The Djerassi-Elias Lunch Symposium | Future of immunotherapy Lunch Symposium | Run for the Million: 13:20-14:20 Institute of Oncology- Technology symposium [Sponsored by Gilead] Inventors’ Contest A on cancer [Students] , Israel, Nobel prize laureate, Irit Avivi, Israel, Avishay Sella, Israel, Ido Wolf, Noam Shomron, Israel, Uri Rozovski, Israel, and Chairs Yehuda Chowers, Israel, Marius Nacht, Israel Israel and Zelig Eshhar, Israel Ronit Satchi-Fainaro, Israel and TBD Using the body machinery to fight cancer: CAR – T cells 2020-2040: Irit Avivi, Israel emerging therapies in the era of biologics: Dror TBD: Matt Trau, Australia Harats, Israel Reversed immuno-oncolgy: Fitting the patient to Gomora: Eynat Finkelstein, Israel Short presentations by students and post-docs the drug: Gal Markel, Israel Keep on searching: the cryptic immune Preparation free colon imaging Capsule (Check- Awards Ceremony checkpoints of cancer: Michal Lotem, Israel cap): Yoav Kimchy, Israel The patient is in the center of the blind spot: A CAR-T for aggressive lymphomas: Abraham personal journey as an inventor, engineer and a Avigdor, Israel patient: Yoav Medan, Israel Beyond Autologous CAR-T CELL: David Avigan, From start-ups to VC: Ran Nussbaum (Pontifax),

USA Israel Classeek Bio: Ziv Shomroni, Israel and Yoram

Biton, Israel

6 | P a g e Program as of 22.09.2019 - Subject to change

The 1st Symposium of Inventions and Innovations – Medicine 2040 (INI): Rewriting the Future of Healthcare Tel Aviv, Israel, November 4-5, 2019

November 5, 2019

14:20-14:40 Dessert

Hall A Hall B Hall C Session 24 | The challenges of military Session 25 | Fighting smoking: Epidemiology Session 26 | Thyroid and parathyroid: Today to 14:40-16:00 healthcare and clinics 2040 Chairs Gilad Twig, Israel and TBD TBD Moshe Phillip, Israel and TBD Innovations and collaborations in military Epidemiology of smoking: Alfred I. Neugut, USA TBD: Rivka Polak, Israel medicine: TBD Epidemiology of smoking in Israel: Lital Keinan Virtual reality and simulators: Amitai Ziv, Israel Boker, Israel TBD: Dan Fliss, Israel

Exterional physiology, new technology and data: Overview of trends and policy: Ministry of health. TBD: TBD The Messi and Ronaldo models: Muly Epstein, Ran Balicer, Israel Israel The UK perspective: Marcus Stow, UK The Future of smoking: Carrie Wade, USA Forensic DNA identification in the US army: The medical hazards of smoking: Amir On, Israel Timothy P. McMahon, USA Understanding the concepts and potential impact

of harm reduction strategies: Laura Rosen, Israel The economic burden of smoking: Amir Shmeuli,

Israel Addiction and rehabilitation: Segev Barak, Israel Current clinical Data on alternatives – Pros and

Cons: Konstantinos Forsalinos, Greece Session 27 | Dermatology 2040: Scratching off Session 28 | Cure of diabetes [Sponsored by Session 29 | Radiologist and the “radio-robot:” 16:00-17:00 the surface of the skin Novonordisk] Friends or foes? Eli Sprecher, Israel, Reuven Bergman, Israel Itamar Raz, Israel, Roy Eldor, Israel and Naftali Arye Blachar, Israel, Jacob Sosna, Israel and Eli Chairs and TBD Stern, Israel Konen, Israel The last days of the traditional skin cancer The return of the doctor’s doctor: Paul Chang, Precision medicine: Hila Knobler, Israel screening? Ayelet Rishpon, Israel USA What have we learned about human health from Curing vascular disorders of the skin: Shoshi Nuclear Medicine – From imaging to therapy of large cardiovascular outcome studies: Itamar Raz, Greenberger, Israel cancer: Einat Even-Sapir, Israel Israel The future of dermatopathology: Reuven The future of diabetes and obesity- from GLP-1 Imaging AI: Myth versus Truth: Gad Levy, Israel Bergman, Israel agonists to coagonists: Roy Eldor, Israel At the interface between skin and cancer: Carmit

Levy, Israel 17:00-17:20 Technical Break

7 | P a g e Program as of 22.09.2019 - Subject to change

The 1st Symposium of Inventions and Innovations – Medicine 2040 (INI): Rewriting the Future of Healthcare Tel Aviv, Israel, November 4-5, 2019

November 5, 2019

Hall A Plenary Session 30 | From the Big Bang to 17:20-18:20 2040 Chairs TBD From the Big Bang to 2040 and beyond: Avishai

Dekel, Israel The Israeli health basket of compulsory services – Legal and moral considerations: Yoram Danzinger, Israel TBD: Ehud Olmert, Israel TBD: Roger Kornberg, USA, Nobel Prize

Laureate Using Game Theory in medical therapy: The Streamline Kidney Transplants: Robert Aumann, Israel, Nobel Prize Laureate Realizing the dreams for a better tomorrow:

Ulrich Betz, Germany

8 | P a g e Program as of 22.09.2019 - Subject to change