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Protein Chemistry ‐ Applications to Combat Diseases Danish Friends of the University of Haifa Protein Chemistry ‐ Applications to Combat Diseases Proteins, from creation to destruction – and what lies in between International Symposium 23‐25 May 2011 at University of Copenhagen Lundbeck Foundation Auditorium Ole Maaløes Vej 5 DK‐2200 Copenhagen Denmark Page 1/7 Protein Chemistry ‐ Applications to Combat Diseases International Symposium in Copenhagen, 23‐25 May 2011 Content Organising Committee...................................................................................................................3 Symposium Sponsors.....................................................................................................................3 Registration......................................................................................................................................3 Key Note Speakers..........................................................................................................................4 Programme Monday, 23 May 2011.............................................................................................5 Programme Monday, 23 May 201, continued...........................................................................6 Programme Tuesday, 24 May 2011.............................................................................................6 Programme Wednesday, 25 May 2011.......................................................................................7 Page 2/7 Protein Chemistry ‐ Applications to Combat Diseases International Symposium in Copenhagen, 23‐25 May 2011 Organising Committee The symposium is organised by The Danish Weizmann Society, Danish Friends of the University of Haifa, Biopeople, and University of Copenhagen. University of Copenhagen is represented by Biopeople and the individuals in the organising committee. • Dr. Ole Farver, Professor, dr. scient., Institute of Analytical and Pharmaceutical Chemistry, University of Copenhagen • Mrs. Malgorzata H. Hansen, MA, Chairman, Danish Friends of the University of Haifa • Dr. Else K. Hoffmann, Professor, PhD, Department of Biology, University of Copenhagen • Dr. Bo Skaaning Jensen, PhD, Scientific Director, Neurosearch A/S • Dr. Jørgen Leisner, Associate Professor, PhD, Department of Veterinary Disease Biology, University of Copenhagen • Dr. Per Spindler, DVM, E‐MBA, MSc, Director, Biopeople, University of Copenhagen • Mr. Elias Zafirakos, MSc , EBA, Science Liaison Officer, Biopeople, University of Copenhagen Symposium Sponsors • The Carlsberg Foundation • The Danish Ministry of Science, Technology and Innovation • Embassy of Israel, Copenhagen • H. Lundbeck A/S • Municipality of Copenhagen Registration The symposium is free of charge except for an administration fee of DKK 200,‐ Online registration is mandatory at www.biopeople.dk Page 3/7 Protein Chemistry ‐ Applications to Combat Diseases International Symposium in Copenhagen, 23‐25 May 2011 Key Note Speakers The key speakers will be the three recent Nobel laureates in chemistry: Professor Avram Hershko and Professor Aaron Ciechanover, Technion‐Israel Institute of Technology, and Professor Ada Yonath, the Weizmann Institute of Science. Avram Hershko was awarded the Nobel Prize in 2004 in Chemistry for his discovery, with Aaron Ciechanover and Irvin Rose, of ubiquitin‐mediated protein degradation. The ubiquitin‐proteasome pathway has a critical role in maintaining the homeostasis of cells and is believed to be involved in the development and progression of diseases such as: cancer, muscular and neurological diseases, immune and inflammatory responses. Aaron Ciechanover was awarded the Nobel Prize in 2004 in Chemistry for his discovery, with Avram Hershko and Irwin Rose of ubiquitin‐mediated protein degradation. The ubiquitin‐proteasome pathway has a critical role in maintaining the homeostasis of cells and is believed to be involved in the development and progression of diseases such as: cancer, muscular and neurological diseases, immune and inflammatory responses. Ada Yonath was awarded the Nobel Prize in 2009 in Chemistry along with Venkatraman Ramakrishnan and Thomas A. Steitz for her studies on the structure and function of the ribosome, becoming the first woman in 45 years to win the Nobel Prize for Chemistry. Important work also includes identifying how bacteria become resistant to antibiotics. Page 4/7 Protein Chemistry ‐ Applications to Combat Diseases International Symposium in Copenhagen, 23‐25 May 2011 Programme Monday, 23 May 2011 8:30 Registration and Coffee 9:00 Organising Committee Welcome by Professor Ole Farver, University of Copenhagen Session Chair: Monica Palcic, Professor, the Carlsberg Laboratory 9:15 Nobel Laureate Ada Yonath: View into the ribosomal exit tunnel 10:00‐10:20 Coffee Session Chair: Monica Palcic, Professor, the Carlsberg Laboratory 10:20 Marina Rodnina: Ribosome function and dynamics 10:45 Yoav Arava: mRNA localization to cellular complexes 11:10 Mark Safro: Quality control of translation in primary kingdoms is conditioned by structural variability of cytoplasmic and organellar aaRSs 11:35 Amnon Horovitz: Allostery in chaperonin‐mediated protein folding 12:00‐13:00 Lunch Session Chair: Ole Thastrup, Professor, University of Copenhagen 13:00 Søren Brunak: Finding disease protein complexes by data integration 13:25 Lars Ellgaard: Making disulfide bonds without stress: efficient redox regulation in the ER 13:50 Deborah Fass: Oxidative Folding and Assembly of Proteins Downstream of the Endoplasmic Reticulum 14:15 Raz Zarivach: Studies of magnetosome‐associated protein MamA 14:40 – 15:20 Coffee and Sign Up for Science Dating (Tuesday 13:00) Session Chair: Ole Thastrup, Professor, University of Copenhagen 15:20 Tali Haran: Protein‐DNA interactions in the p53 system and its dependence on DNA structural properties 15:45 Poul Nissen: P‐type ATPase ‐ common and specific mechanisms of cation pumps 16:10 Abraham Loyter: Peptides as a tool to study regulation of Retroviruses infection 16:35 Assaf Friedler: Using peptides to modulate the oligomeric states of proteins Page 5/7 Protein Chemistry ‐ Applications to Combat Diseases International Symposium in Copenhagen, 23‐25 May 2011 Programme Monday, 23 May 2011, continued 17:00 Ivan Dikic: Ubiquitin networks in regulation of inflammation and autophagy 17:25 Networking; Drinks; End of scientific programme Day 1 19:30 Speakers reception dinner Programme Tuesday, 24 May 2011 8:30 Registration and Coffee Session Chair: Peter Høngaard Andersen, Vice President Research, H. Lundbeck A/S 9:00 Nobel Laureate Key Avram Hershko: Regulation of the cell division cycle by ubiquitin‐mediated protein degradation 9:45‐10:00 Coffee 10:00 Niels Mailand: Non‐proteolytic functions of ubiquitin in cellular responses to DNA Damage 10:25 Daniel Finley: Regulation of the proteasome by ubiquitin chain editing 10:50 Sarit Larisch: Role of the pro‐apoptotic ARTS protein in apoptosis and tumor suppression 11:15 Hermann Steller: Death by degradation: regulation of apoptosis by the ubiquitin‐ proteasome system 11:40 Bio Break 11:45 Rasmus Hartmann‐Petersen: Proteasome co‐factors channel misfolded proteins for degradation 12:10 Michael Glickman: A perturbed Ubiquitin landscape distinguishes between ubiquitin in trafficking and in proteolysis 12:35 Daniel Kornitzer: Role of protein degradation in fungal development 13:00‐14:00 Lunch Buffet 14:00‐15:00 Science Dating with Nobel Laureates and Speakers Page 6/7 Protein Chemistry ‐ Applications to Combat Diseases International Symposium in Copenhagen, 23‐25 May 2011 Session Chair: Jakob R. Winther, Professor, University of Copenhagen 15:00 Allan Weissman: Insights into the function of ubiquitin ligases 15:25 Benjamin Podbilewicz: Fusogens Sculpting Cells and Organs 15:50 Ariel Stanhill: Translational regulation as a means to adjust protein degradation 16:15 Networking; Drinks; End of Day 2 Presentations 19:00 Working Dinner – only for speakers and specially invited delegates 22:00 End of Day 2 Programme Wednesday, 25 May 2011 8:30 Registration and coffee Session Chair: Bo Skaaning Jensen, Neurosearch A/S 9:00 Nobel Laureate Aaron Ciechanover: Why Our Proteins Have to Die so We shall Live; or The Ubiquitin Proteolytic System ‐ From Basic Mechanisms thru Human Diseases and onto Drug Development 9:45‐10:15 Coffee and Homemade Cakes 10:15 Poul Henning Jensen: α‐Synuclein aggregation and toxic intracellular pathways 10:40 Alfred Goldberg: New insights into proteasomal mechanisms 11:05 – 12:30 Networking; End of Day 3 Presentations 12:30 Departure to City Hall of Copenhagen 13:00 Lunch Reception and Farewell at the Copenhagen City Hall 15:00 End of Symposium Page 7/7 .
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