Danish Friends of the University of Haifa
Protein Chemistry ‐ Applications to Combat Diseases
Proteins, from creation to destruction – and what lies in between
International Symposium 23‐25 May 2011
at
University of Copenhagen Lundbeck Foundation Auditorium Ole Maaløes Vej 5 DK‐2200 Copenhagen Denmark
Page 1/7 Protein Chemistry ‐ Applications to Combat Diseases International Symposium in Copenhagen, 23‐25 May 2011
Content
Organising Committee...... 3 Symposium Sponsors...... 3 Registration...... 3 Key Note Speakers...... 4 Programme Monday, 23 May 2011...... 5 Programme Monday, 23 May 201, continued...... 6 Programme Tuesday, 24 May 2011...... 6 Programme Wednesday, 25 May 2011...... 7
Page 2/7 Protein Chemistry ‐ Applications to Combat Diseases International Symposium in Copenhagen, 23‐25 May 2011
Organising Committee The symposium is organised by The Danish Weizmann Society, Danish Friends of the University of Haifa, Biopeople, and University of Copenhagen. University of Copenhagen is represented by Biopeople and the individuals in the organising committee.
• Dr. Ole Farver, Professor, dr. scient., Institute of Analytical and Pharmaceutical Chemistry, University of Copenhagen
• Mrs. Malgorzata H. Hansen, MA, Chairman, Danish Friends of the University of Haifa
• Dr. Else K. Hoffmann, Professor, PhD, Department of Biology, University of Copenhagen
• Dr. Bo Skaaning Jensen, PhD, Scientific Director, Neurosearch A/S
• Dr. Jørgen Leisner, Associate Professor, PhD, Department of Veterinary Disease Biology, University of Copenhagen
• Dr. Per Spindler, DVM, E‐MBA, MSc, Director, Biopeople, University of Copenhagen
• Mr. Elias Zafirakos, MSc , EBA, Science Liaison Officer, Biopeople, University of Copenhagen
Symposium Sponsors • The Carlsberg Foundation
• The Danish Ministry of Science, Technology and Innovation
• Embassy of Israel, Copenhagen
• H. Lundbeck A/S
• Municipality of Copenhagen
Registration The symposium is free of charge except for an administration fee of DKK 200,‐
Online registration is mandatory at www.biopeople.dk
Page 3/7 Protein Chemistry ‐ Applications to Combat Diseases International Symposium in Copenhagen, 23‐25 May 2011
Key Note Speakers The key speakers will be the three recent Nobel laureates in chemistry: Professor Avram Hershko and Professor Aaron Ciechanover, Technion‐Israel Institute of Technology, and Professor Ada Yonath, the Weizmann Institute of Science.
Avram Hershko was awarded the Nobel Prize in 2004 in Chemistry for his discovery, with Aaron Ciechanover and Irvin Rose, of ubiquitin‐mediated protein degradation. The ubiquitin‐proteasome pathway has a critical role in maintaining the homeostasis of cells and is believed to be involved in the development and progression of diseases such as: cancer, muscular and neurological diseases, immune and inflammatory responses.
Aaron Ciechanover was awarded the Nobel Prize in 2004 in Chemistry for his discovery, with Avram Hershko and Irwin Rose of ubiquitin‐mediated protein degradation. The ubiquitin‐proteasome pathway has a critical role in maintaining the homeostasis of cells and is believed to be involved in the development and progression of diseases such as: cancer, muscular and neurological diseases, immune and inflammatory responses.
Ada Yonath was awarded the Nobel Prize in 2009 in Chemistry along with Venkatraman Ramakrishnan and Thomas A. Steitz for her studies on the structure and function of the ribosome, becoming the first woman in 45 years to win the Nobel Prize for Chemistry. Important work also includes identifying how bacteria become resistant to antibiotics.
Page 4/7 Protein Chemistry ‐ Applications to Combat Diseases International Symposium in Copenhagen, 23‐25 May 2011
Programme Monday, 23 May 2011 8:30 Registration and Coffee
9:00 Organising Committee Welcome by Professor Ole Farver, University of Copenhagen
Session Chair: Monica Palcic, Professor, the Carlsberg Laboratory
9:15 Nobel Laureate Ada Yonath: View into the ribosomal exit tunnel
10:00‐10:20 Coffee
Session Chair: Monica Palcic, Professor, the Carlsberg Laboratory
10:20 Marina Rodnina: Ribosome function and dynamics
10:45 Yoav Arava: mRNA localization to cellular complexes
11:10 Mark Safro: Quality control of translation in primary kingdoms is conditioned by structural variability of cytoplasmic and organellar aaRSs
11:35 Amnon Horovitz: Allostery in chaperonin‐mediated protein folding
12:00‐13:00 Lunch
Session Chair: Ole Thastrup, Professor, University of Copenhagen
13:00 Søren Brunak: Finding disease protein complexes by data integration
13:25 Lars Ellgaard: Making disulfide bonds without stress: efficient redox regulation in the ER
13:50 Deborah Fass: Oxidative Folding and Assembly of Proteins Downstream of the Endoplasmic Reticulum
14:15 Raz Zarivach: Studies of magnetosome‐associated protein MamA
14:40 – 15:20 Coffee and Sign Up for Science Dating (Tuesday 13:00)
Session Chair: Ole Thastrup, Professor, University of Copenhagen
15:20 Tali Haran: Protein‐DNA interactions in the p53 system and its dependence on DNA structural properties
15:45 Poul Nissen: P‐type ATPase ‐ common and specific mechanisms of cation pumps
16:10 Abraham Loyter: Peptides as a tool to study regulation of Retroviruses infection
16:35 Assaf Friedler: Using peptides to modulate the oligomeric states of proteins
Page 5/7 Protein Chemistry ‐ Applications to Combat Diseases International Symposium in Copenhagen, 23‐25 May 2011
Programme Monday, 23 May 2011, continued
17:00 Ivan Dikic: Ubiquitin networks in regulation of inflammation and autophagy
17:25 Networking; Drinks; End of scientific programme Day 1
19:30 Speakers reception dinner
Programme Tuesday, 24 May 2011
8:30 Registration and Coffee
Session Chair: Peter Høngaard Andersen, Vice President Research, H. Lundbeck A/S
9:00 Nobel Laureate Key Avram Hershko: Regulation of the cell division cycle by ubiquitin‐mediated protein degradation
9:45‐10:00 Coffee
10:00 Niels Mailand: Non‐proteolytic functions of ubiquitin in cellular responses to DNA
Damage
10:25 Daniel Finley: Regulation of the proteasome by ubiquitin chain editing
10:50 Sarit Larisch: Role of the pro‐apoptotic ARTS protein in apoptosis and tumor suppression
11:15 Hermann Steller: Death by degradation: regulation of apoptosis by the ubiquitin‐ proteasome system
11:40 Bio Break
11:45 Rasmus Hartmann‐Petersen: Proteasome co‐factors channel misfolded proteins for degradation
12:10 Michael Glickman: A perturbed Ubiquitin landscape distinguishes between ubiquitin in trafficking and in proteolysis
12:35 Daniel Kornitzer: Role of protein degradation in fungal development
13:00‐14:00 Lunch Buffet
14:00‐15:00 Science Dating with Nobel Laureates and Speakers
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Session Chair: Jakob R. Winther, Professor, University of Copenhagen
15:00 Allan Weissman: Insights into the function of ubiquitin ligases
15:25 Benjamin Podbilewicz: Fusogens Sculpting Cells and Organs
15:50 Ariel Stanhill: Translational regulation as a means to adjust protein degradation
16:15 Networking; Drinks; End of Day 2 Presentations
19:00 Working Dinner – only for speakers and specially invited delegates
22:00 End of Day 2
Programme Wednesday, 25 May 2011
8:30 Registration and coffee
Session Chair: Bo Skaaning Jensen, Neurosearch A/S
9:00 Nobel Laureate Aaron Ciechanover: Why Our Proteins Have to Die so We shall Live; or The Ubiquitin Proteolytic System ‐ From Basic Mechanisms thru Human Diseases and onto Drug Development
9:45‐10:15 Coffee and Homemade Cakes
10:15 Poul Henning Jensen: α‐Synuclein aggregation and toxic intracellular pathways
10:40 Alfred Goldberg: New insights into proteasomal mechanisms
11:05 – 12:30 Networking; End of Day 3 Presentations
12:30 Departure to City Hall of Copenhagen
13:00 Lunch Reception and Farewell at the Copenhagen City Hall
15:00 End of Symposium
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