Nobel Letter Attny Gen Garland 5-4-2021
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Caso Relativamente Recente
Perché chiamiamo “fondamentale” la Cenerentola della ricerca? (di M. Brunori) Neanche nel Pnrr si trovano speranze di cambiamento e iniziative coraggiose per la ricerca di base. Ma nelle scienze della vita non sono rare le scoperte nate da progetti di ricerca curiosity driven che richiedono tempo per portare risultati Soci dell'Accademia dei Lincei. (a cura di Maurizio Brunori, Prof. emerito di Chimica e Biochimica, Sapienza Università di Roma, Presidente emerito della Classe di Scienze FMN dell’Accademia dei Lincei) Nelle scienze della vita non sono infrequenti le scoperte innovative nate da progetti di ricerca di base, iniziati per cercare di comprendere qualche importante proprietà di un essere vivente, misteriosa ma ovviamente necessaria se è stata conservata nel corso dell’evoluzione. Questi progetti sono quelli che si iniziano per curiosità intellettuale, ma richiedono libertà di iniziativa, impegno pluriennale e molto coraggio in quanto di difficile soluzione. Un successo straordinario noto a molti è quello ottenuto dieci anni fa da due straordinarie ricercatrici, Emmanuelle Charpentier e Jennifer Doudna; che a dicembre hanno ricevuto dal Re di Svezia il Premio Nobel per la Chimica con la seguente motivazione: “for the development of a new method for genome editing”. Nel 2018 in occasione di una conferenza magistrale che la Charpentier tenne presso l’Accademia Nazionale dei Lincei, avevo pubblicato sul Blog di HuffPost un pezzo per commentare l’importanza della scoperta di CRISPR/Cas9, un kit molecolare taglia-e-cuci che consente di modificare con precisione ed efficacia senza precedenti il genoma di qualsiasi essere vivente: batteri, piante, animali, compreso l’uomo. NOBEL PRIZE Nobel Chimica Non era mai accaduto che due donne vincessero insieme il Premio Nobel. -
Paul Hardin, Ph.D. John W
Department of Biology The College of Arts + Sciences | Indiana University Bloomington About Paul Hardin Distinguished Alumni Award Lecture Thu., Oct. 18, 2018 • 4 to 5 pm • Myers Hall 130 Paul Hardin, Ph.D. John W. Lyons Jr. ’59 Chair in Biology, Texas A&M University Genetic architecture underlying circadian clock initiation, maintenance, and output in Drosophila Circadian clocks drive daily rhythms in metabolism, physiology, and behavior in organisms ranging from cyanobacteria to humans. The identification and analysis of “clock genes” in Drosophila revealed that circadian timekeeping is based on a transcriptional feedback loop Paul Hardin studied the development of the sea in which CLOCK-CYCLE (CLK-CYC) heterodimers activate transcription of their feedback urchin embryo in William Klein’s lab at Indiana repressors PERIOD (PER) and TIMELESS (TIM). Subsequent studies revealed that similar University, from where he received his Ph.D. in transcriptional feedback loops keep circadian time in all eukaryotes and, in the case of 1987. He did his postdoctoral fellowship with animals, that these feedback loops are comprised of conserved components. The “core” Michael Rosbash at Brandeis University, working feedback loop described above operates in conjunction with an “interlocked” feedback on the circadian rhythms of the fruit fly, Drosophila loop in animals to drive rhythmic transcription of hundreds of genes that are maximally melanogaster. His work with Michael Rosbash and expressed at different phases of the circadian cycle. These feedback loops operate in many, Jeff Hall has been instrumental to our understanding but not all, tissues in flies including the brain pacemaker neurons that control rest:activity of how circadian rhythms affect a myriad of rhythms. -
RNA Society Newsletter August 2013
RNA Society Newsletter August 2013 From the Desk of the President, Rachel Green Whether we are taking classes, teaching classes, or just living our lives under the umbrella of the academic cycle, summer marks the time for sharing what we have learned during those long dark winter months. For the RNA Society, this summer was no exception where many of us attended the 18th annual RNA Society meeting in the heart of the Alps in Davos, Switzerland to share our new data and ideas. (Continued on p2) In this issue : From the Desk of the President, Rachel Green 1 RNA 2013 Meeting Review: Davos, Switzerland Election Results Announced 4 Junior Scientist Meetings Summary 4 RNA Lifetime Achievement Award 6 Volunteer Positions Available 7 Junior Scientist Corner 8 Chair of the Meetings Committee, David Lilley 9 From the desk of our CEO, James McSwiggen 11 Thank you volunteers 13 RNA Society supported meetings Meetings Reports 16 Upcoming meetings of interest 18 Employment Opportunities 21 1 The meeting organizers this year included the opening evening of the meeting a full session of two Swiss natives, Frederic Allain and Witold science was planned, headed off by Venki Filipowicz, as well as Adrian Krainer (RNA Ramakrishnan who gave a beautiful talk bringing Society president elect!), Osamu Nureki and Sarah together biochemical Woodson. In addition to their excellent guidance, the and structural organizers were helped at the organizational level by perspectives on the Simple Meetings (including Kristin Scheyer and process of decoding Mary McCann) who over the years have really during protein figured out our needs. -
The 2016 Nobel Prize in Chemistry
Pure Appl. Chem. 2016; 88(10-11): 917–918 Editorial Hugh D. Burrows* and Richard M. Hartshorn* The 2016 Nobel Prize in Chemistry DOI 10.1515/pac-2016-2005 Keywords: Ben L. Feringa; Jean-Pierre Sauvage; J. Fraser Stoddart; Nobel Prize in Chemistry; 2016. Pure and Applied Chemistry warmly congratulates Jean-Pierre Sauvage (University of Strasbourg, France), Sir J. Fraser Stoddart (Northwestern University, Evanston, IL, USA), and Bernard (Ben) L. Feringa (Univer- sity of Groningen, the Netherlands) on their award of the 2016 Nobel Prize in Chemistry. The citation from the Royal Swedish Academy of Sciences states that the award is “for the design and synthesis of molecu- lar machines”. Their work encompasses a broad spectrum of Chemistry, from elegant synthetic studies of catenanes, rotaxanes and other formerly considered exotic molecules, through coordination chemistry, and electron transfer reactions, to molecular switches and rotors driven by light and other external sources. They have all participated actively in IUPAC endorsed meetings and conference series, including the IUPAC World Congress in Chemistry, IUPAC International Conferences on Organic Synthesis (ICOS), Physical Organic Chemistry (ICPOC), and Coordination Chemistry (ICCC), and IUPAC International Symposia on Macrocyclic Chemistry (ISMC), Organometallic Chemistry Directed Towards Organic Synthesis (OMCOS), Novel Aromatic Compounds (ISNA), Carbohydrate Chemistry (ICS), the Chemistry of Natural Products ISCNP), and Photo- chemistry. Pure Appl. Chem. publishes collections of papers based upon authoritative lectures presented at such IUPAC endorsed events, in addition to IUPAC Recommendations, and Technical Reports. We are very pleased to highlight the following publications from these three Nobel Laureates that have been published in Pure and Applied Chemistry as a result of their involvement in these conferences. -
Fall 2019 SPECIAL DAY/TIME/LOCATION: Friday
The Chemistry and Biochemistry Departmental Seminar Series covers a broad range of fields in the Chemical and Biochemical Sciences. In past seminars, scientists from Academia, Government, and Industry have presented their most recent discoveries and contributions in their respective areas. This Seminar Series offers students and faculty the opportunity to interact directly with other leaders in their specializations and to gain a good overview of the entire range of fields in Chemistry and Biochemistry. Fall 2019 Seminars are held on Tuesdays in CL 1009 (Clendenin Building, Room 1009 on the Kennesaw Campus), 12:30 - 1:30pm, unless otherwise noted with special day/time/location information. All are invited to attend. SPECIAL DAY/TIME/LOCATION: Friday, September 20, 2019 – 2:30pm in CL 2003 Dr. Jeffrey I. Seeman, Department of Chemistry, University of Richmond Title: Was Plagiarism Involved in the Conceptualization of the Woodward-Hoffmann Rules? Abstract: In 1981, Roald Hoffmann and Kenichi Fukui shared the Nobel Prize in Chemistry “for their theories, developed independently, concerning the course of chemical reactions.” Had Robert B. Woodward (1917 – 1979) lived two years longer, he would surely have received his second Nobel Prize in Chemistry for his contributions to the Woodward-Hoffmann rules. In the March 29, 2004 issue of Chemical & Engineering News, E. J. Corey wrote in his Priestley Medal Address, “On May 4, 1964, I suggested to my colleague R. B. Woodward a simple explanation involving the symmetry of the perturbed (HOMO) molecular orbitals for the stereoselective cyclobutene/1,3-butadiene and 1,3,5-hexatriene/cyclohexadiene conversions that provided the basis for the further development of these ideas into what became known as the Woodward-Hoffmann rules.” Letters between Corey and Hoffmann in 1981 and 1984 and other relevant information will be shown and discussed. -
Nobel Lecture, 8 December 1981 by ROALD HOFFMANN Department of Chemistry, Cornell University, Ithaca, N.Y
BUILDING BRIDGES BETWEEN INORGANIC AND ORGANIC CHEMISTRY Nobel lecture, 8 December 1981 by ROALD HOFFMANN Department of Chemistry, Cornell University, Ithaca, N.Y. 14853 R. B. Woodward, a supreme patterner of chaos, was one of my teachers. I dedicate this lecture to him, for it is our collaboration on orbital symmetry conservation, the electronic factors which govern the course of chemical reac- tions, which is recognized by half of the 1981 Nobel Prize in Chemistry. From Woodward I learned much: the significance of the experimental stimulus to theory, the craft of constructing explanations, the importance of aesthetics in science. I will try to show you how these characteristics of chemical theory may be applied to the construction of conceptual bridges between inorganic and organic chemistry. FRAGMENTS Chains, rings, substituents - those are the building blocks of the marvelous edifice of modern organic chemistry. Any hydrocarbon may be constructed on paper from methyl groups, CH 3, methylenes, CH 2, methynes, CH, and carbon atoms, C. By substitution and the introduction of heteroatoms all of the skeletons and functional groupings imaginable, from ethane to tetrodotoxin, may be obtained. The last thirty years have witnessed a remarkable renaissance of inorganic chemistry, and the particular flowering of the field of transition metal organo- metallic chemistry. Scheme 1 shows a selection of some of the simpler creations of the laboratory in this rich and ever-growing field. Structures l-3 illustrate at a glance one remarkable feature of transition metal fragments. Here are three iron tricarbonyl complexes of organic moie- ties - cyclobutadiene, trimethylenemethane, an enol, hydroxybutadiene - which on their own would have little kinetic or thermodynamic stability. -
Chemical Synthesis
www.iupac2017.org Adriano D. Andricopulo Chairman of the IUPAC-2017 Organizing Committee Brazil: Key Figures and Facts • Brazil is Latin America's largest country (47% of the South America Continent) and the fifth largest country in the world • Population: 204 million people (the fifth most populous in the world ) • Language: Portuguese . Official currency: Brazilian Real (1.00 USD = R$ 3.12) • Brazil has the world’s ninth-largest economy and the largest in Latin America Brazil: Key Figures and Facts . São Paulo has the largest population, industrial complex, and economic production in Brazil . Population: 12 million people (45 million in SP state) . It is the largest city in South America, and the fifth largest in the world . São Paulo State is responsible for 40% of the Brazilian GDP . Climate: humid subtropical, temperatures in July: 12 and 22°C (54°F and 72°F) . Number of tourists in 2016: > 18 million WTC Events Center and Sheraton WTC Hotel are the most complete complex for events in Latin America Approximately 12,000 m² are available and divided into 60 flexible spaces Services: Parking Restaurants Banks Currency exchange Travel agency Pharmacies Hairdresser’s Stationery General Aspects - 9 Plenary Lectures, including 4 Noble Laureates - About 120 Sessions in 12 major themes - Several Keynote, Invited, Oral and Young Scientists Opening Ceremony Special Symposia Welcome Reception 3 Poster Sessions Half-day Social Program Gala Dinner Exhibition Plenary Lectures Sir J. Fraser Stoddart (Nobel Prize 2016) Department of Chemistry -
Nobel Laureates Endorse Joe Biden
Nobel Laureates endorse Joe Biden 81 American Nobel Laureates in Physics, Chemistry, and Medicine have signed this letter to express their support for former Vice President Joe Biden in the 2020 election for President of the United States. At no time in our nation’s history has there been a greater need for our leaders to appreciate the value of science in formulating public policy. During his long record of public service, Joe Biden has consistently demonstrated his willingness to listen to experts, his understanding of the value of international collaboration in research, and his respect for the contribution that immigrants make to the intellectual life of our country. As American citizens and as scientists, we wholeheartedly endorse Joe Biden for President. Name Category Prize Year Peter Agre Chemistry 2003 Sidney Altman Chemistry 1989 Frances H. Arnold Chemistry 2018 Paul Berg Chemistry 1980 Thomas R. Cech Chemistry 1989 Martin Chalfie Chemistry 2008 Elias James Corey Chemistry 1990 Joachim Frank Chemistry 2017 Walter Gilbert Chemistry 1980 John B. Goodenough Chemistry 2019 Alan Heeger Chemistry 2000 Dudley R. Herschbach Chemistry 1986 Roald Hoffmann Chemistry 1981 Brian K. Kobilka Chemistry 2012 Roger D. Kornberg Chemistry 2006 Robert J. Lefkowitz Chemistry 2012 Roderick MacKinnon Chemistry 2003 Paul L. Modrich Chemistry 2015 William E. Moerner Chemistry 2014 Mario J. Molina Chemistry 1995 Richard R. Schrock Chemistry 2005 K. Barry Sharpless Chemistry 2001 Sir James Fraser Stoddart Chemistry 2016 M. Stanley Whittingham Chemistry 2019 James P. Allison Medicine 2018 Richard Axel Medicine 2004 David Baltimore Medicine 1975 J. Michael Bishop Medicine 1989 Elizabeth H. Blackburn Medicine 2009 Michael S. -
The Nobel Prize in Chemistry 2013 the Royal Swedish Academy of Sciences Has Decided to Award the Nobel Prize in Chemistry for 2013 To
PRESSMEDDELANDE Press release 9 October 2013 The Nobel Prize in Chemistry 2013 The Royal Swedish Academy of Sciences has decided to award the Nobel Prize in Chemistry for 2013 to Martin Karplus Michael Levitt Arieh Warshel Université de Strasbourg, France and Stanford University School of Medicine, University of Southern California, Harvard University, Cambridge, MA, USA Stanford, CA, USA Los Angeles, CA, USA “for the development of multiscale models for complex chemical systems” The computer — your Virgil in the world of atoms Chemists used to create models of molecules This year’s Nobel Laureates in chemistry took the best using plastic balls and sticks. Today, the modelling from both worlds and devised methods that use both is carried out in computers. In the 1970s, Martin classical and quantum physics. For instance, in simu- Karplus, Michael Levitt and Arieh Warshel laid the lations of how a drug couples to its target protein in foundation for the powerful programs that are used the body, the computer performs quantum theoretical to understand and predict chemical processes. calculations on those atoms in the target protein that Computer models mirroring real life have become interact with the drug. The rest of the large protein is crucial for most advances made in chemistry today. simulated using less demanding classical physics. Chemical reactions occur at lightning speed. In a fraction Today the computer is just as important a tool for of a millisecond, electrons jump from one atomic nucleus chemists as the test tube. Simulations are so realistic to the other. Classical chemistry has a hard time keeping that they predict the outcome of traditional experiments. -
Dear Colleague, This Invitation Is Being Sent on Behalf of Prof
Dear colleague, On behalf of Prof. Fernand Marquis (San Diego State U., USA), Prof. Soteris Kalogirou (Cyprus U. of Technology, Cyprus), and Prof. Bernard Raveau (U. of Caen, France), co-chairs of the 2nd International Symposium on Solid State Chemistry for Applications and Sustainable Development in my capacity as President of SIPS 2020/2021, I am personally inviting you to participate as an author/speaker. This major symposium focuses on solid-state chemistry corresponds to the relationships occurring between the synthesis, structure, and physical-chemical properties of solid inorganic compounds (in most cases), leading to a final compound with optimized properties such as advances in the synthesis routes, design of materials for sustainable energy production, advanced characterization techniques and applications, etc. These and many others are among the topics of the symposium. This symposium will be held as part of the combined SIPS 2020/2021, an annual multidisciplinary summit, organized by the not-for-profit corporation FLOGEN Stars Outreach (www.flogen.org), which is dedicated to achieving sustainability through science and technology applied in various fields. It incorporates summit plenary lectures from well-known speakers that address the link between various domains in the pursuit of sustainable development, as well as specific scientific symposia featuring specialized presentations in a specific domain, with the same goals in mind. The symposium and overall summit are planned to be held in Phuket, Thailand from November 28th – December 2nd 2021. We have confirmed until now the participation of the following 9 Nobel Laureates: Prof. Dan Shechtman, Prof. Didier Queloz, Prof. M. Stanley Whittingham, Sir Konstantin Novoselov, Prof. -
Molecular Geometry and Molecular Graphics: Natta's Polypropylene And
Molecular geometry and molecular graphics: Natta's polypropylene and beyond Guido Raos Dip. di Chimica, Materiali e Ing. Chimica \G. Natta", Politecnico di Milano Via L. Mancinelli 7, 20131 Milano, Italy [email protected] Abstract. In this introductory lecture I will try to summarize Natta's contribution to chemistry and materials science. The research by his group, which earned him the Noble prize in 1963, provided unprece- dented control over the synthesis of macromolecules with well-defined three-dimensional structures. I will emphasize how this structure is the key for the properties of these materials, or for that matter for any molec- ular object. More generally, I will put Natta's research in a historical context, by discussing the pervasive importance of molecular geometry in chemistry, from the 19th century up to the present day. Advances in molecular graphics, alongside those in experimental and computational methods, are allowing chemists, materials scientists and biologists to ap- preciate the structure and properties of ever more complex materials. Keywords: molecular geometry, stereochemistry, chirality, polymers, self-assembly, Giulio Natta To be presented at the 18th International Conference on Geometry and Graphics, Politecnico di Milano, August 2018: http://www.icgg2018.polimi.it/ 1 Introduction: the birth of stereochemistry Modern chemistry was born in the years spanning the transition from the 18th to the 19th century. Two key figures were Antoine Lavoisier (1943-1794), whose em- phasis on quantitative measurements helped to transform alchemy into a science on an equal footing with physics, and John Dalton (1766-1844), whose atomic theory provided a simple rationalization for the way chemical elements combine with each other to form compounds. -
Date: To: September 22, 1 997 Mr Ian Johnston©
22-SEP-1997 16:36 NOBELSTIFTELSEN 4& 8 6603847 SID 01 NOBELSTIFTELSEN The Nobel Foundation TELEFAX Date: September 22, 1 997 To: Mr Ian Johnston© Company: Executive Office of the Secretary-General Fax no: 0091-2129633511 From: The Nobel Foundation Total number of pages: olO MESSAGE DearMrJohnstone, With reference to your fax and to our telephone conversation, I am enclosing the address list of all Nobel Prize laureates. Yours sincerely, Ingr BergstrSm Mailing address: Bos StU S-102 45 Stockholm. Sweden Strat itddrtSMi Suircfatan 14 Teleptelrtts: (-MB S) 663 » 20 Fsuc (*-«>!) «W Jg 47 22-SEP-1997 16:36 NOBELSTIFTELSEN 46 B S603847 SID 02 22-SEP-1997 16:35 NOBELSTIFTELSEN 46 8 6603847 SID 03 Professor Willis E, Lamb Jr Prof. Aleksandre M. Prokhorov Dr. Leo EsaJki 848 North Norris Avenue Russian Academy of Sciences University of Tsukuba TUCSON, AZ 857 19 Leninskii Prospect 14 Tsukuba USA MSOCOWV71 Ibaraki Ru s s I a 305 Japan 59* c>io Dr. Tsung Dao Lee Professor Hans A. Bethe Professor Antony Hewlsh Department of Physics Cornell University Cavendish Laboratory Columbia University ITHACA, NY 14853 University of Cambridge 538 West I20th Street USA CAMBRIDGE CB3 OHE NEW YORK, NY 10027 England USA S96 014 S ' Dr. Chen Ning Yang Professor Murray Gell-Mann ^ Professor Aage Bohr The Institute for Department of Physics Niels Bohr Institutet Theoretical Physics California Institute of Technology Blegdamsvej 17 State University of New York PASADENA, CA91125 DK-2100 KOPENHAMN 0 STONY BROOK, NY 11794 USA D anni ark USA 595 600 613 Professor Owen Chamberlain Professor Louis Neel ' Professor Ben Mottelson 6068 Margarldo Drive Membre de rinstitute Nordita OAKLAND, CA 946 IS 15 Rue Marcel-Allegot Blegdamsvej 17 USA F-92190 MEUDON-BELLEVUE DK-2100 KOPENHAMN 0 Frankrike D an m ar k 599 615 Professor Donald A.