Supplymentary Table. 2 Time-Dependently Expressed Genes in ALDH-Negative 4T1 Cells Implanted in Mice

Home , CatSper4, CUB domain, DGKG, GNAL, HDAC4, HMGN1

Supplymentary Table. 2 Time-dependently expressed genes in ALDH-negative 4T1 cells implanted in mice. The list of genes expressed in ALDH-negative cells in which the levels were higher at ZT0 than at ZT12

Fold changes GeneSymbol Description ALDH (-) > ALDH (+) ZT0/ZT12 Abcd2 ATP-binding cassette, sub-family D, member 2 13.176 7.535 Acap2 ArfGAP with coiled-coil, ankyrin repeat and PH domains 2, transcript variant X2 9.670 4.273 Acrbp proacrosin binding protein, transcript variant 1 10.252 8.057 Adam19 a disintegrin and metallopeptidase domain 19 , transcript variant 3 8.317 10.768 Adam3 a disintegrin and metallopeptidase domain 3 18.374 8.683 Adam30 a disintegrin and metallopeptidase domain 30 20.160 21.014 Adrb2 adrenergic receptor, beta 2 13.293 13.137 Aloxe3 arachidonate lipoxygenase 3 24.507 7.098 Alyref Aly/REF export factor 27.890 10.569 Amer2 APC membrane recruitment 2 , transcript variant X1 16.220 8.721 Amhr2 anti-Mullerian hormone type 2 receptor 54.634 29.279 Ampd3 adenosine monophosphate deaminase 3 , transcript variant 1 23.215 17.897 Ankrd12 ankyrin repeat domain 12 13.690 6.463 Ankrd33b ankyrin repeat domain 33B , transcript variant 3 9.244 13.636 Arfgap2 ADP-ribosylation factor GTPase activating protein 2 , transcript variant 2 11.299 2.587 Arrdc3 arrestin domain containing 3 9.396 9.596 Atp11a ATPase, class VI, type 11A , transcript variant 1 14.356 10.541 Atp11b ATPase, class VI, type 11B 18.769 17.377 Avil advillin 9.816 4.876 Bmx BMX non-receptor tyrosine kinase 20.619 21.406 Capns2 calpain, small subunit 2 22.592 25.870 Catip ciliogenesis associated TTC17 interacting protein 10.110 11.787 Ccdc146 coiled-coil domain containing 146 16.307 11.084 Ccdc88c coiled-coil domain containing 88C, transcript variant X1 8.102 10.126 Ccno cyclin O 8.133 11.571 Ccnt2 cyclin T2 25.604 5.658 Cd177 CD177 antigen 9.300 7.761 Cd46 CD46 antigen, complement regulatory protein 8.479 12.784 Cd52 CD52 antigen 16.611 4.538 Cd55 CD55 antigen 11.343 4.447 Cdk17 cyclin-dependent kinase 17 9.491 7.802 Cdk19 cyclin-dependent kinase 19 , transcript variant 1 8.152 7.810 Ceacam10 carcinoembryonic antigen-related cell adhesion molecule 10 8.484 15.183 Celsr3 cadherin, EGF LAG seven-pass G-type receptor 3 13.110 13.654 Cers6 ceramide synthase 6 9.709 6.696 Chrm3 cholinergic receptor, muscarinic 3, cardiac 10.888 10.710 Clec4a4 C-type lectin domain family 4, member a4 13.056 5.204 Clmn calmin, transcript variant 5 24.175 13.585 Cmah cytidine monophospho-N-acetylneuraminic acid hydroxylase (Cmah), transcript variant 1 11.037 14.710 Col22a1 collagen, type XXII, alpha 1 11.147 6.179 Cpd carboxypeptidase D 26.527 17.626 Cpeb2 cytoplasmic polyadenylation element binding protein 2, transcript variant 1 10.289 18.607 Cpne8 copine VIII , transcript variant 2 21.388 4.261 Cxcl12 chemokine (C-X-C motif) ligand 12, transcript variant 3 9.854 4.847 Dach1 dachshund 1, transcript variant 1 13.843 23.181 Dfna5 deafness, autosomal dominant 5 9.874 12.844 Dgkg diacylglycerol kinase, gamma 11.314 6.958 Dgkh diacylglycerol kinase, eta, transcript variant X2 9.640 5.770 Dhrs9 dehydrogenase/reductase member 9 10.041 18.467 Dnmbp dynamin binding protein , transcript variant 1 9.614 5.805 Edn1 endothelin 1 24.813 8.534 Efr3b EFR3 homolog B 10.418 7.326 Egr1 early growth response 1 11.787 16.177 Eid3 EP300 interacting inhibitor of differentiation 3 13.440 3.653 Elmo1 engulfment and cell motility 1 , transcript variant 3 11.588 4.957 Ereg epiregulin 29.129 39.787 Fam209 family with sequence similarity 209 12.035 9.394 Fam20c family with sequence similarity 20, member C 8.549 5.541 Fbxl5 F-box and leucine-rich repeat protein 5 11.103 14.567 Fcrl1 Fc receptor-like 1 , transcript variant 2 15.075 4.967 Fgl1 fibrinogen-like protein 1 9.574 19.115 Fkbp15 FK506 binding protein 15 , transcript variant X2 13.662 5.549 G6pd2 glucose-6-phosphate dehydrogenase 2 8.742 7.794 Galnt6 UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 6 , transcript variant11.482 2 8.408 Gcc1 golgi coiled coil 1 22.466 23.178 Gcnt1 glucosaminyl N-acetyl transferase 1, core 2, transcript variant 1 11.632 14.910 Ggt1 gamma-glutamyltransferase 1, transcript variant 1 22.263 38.571 Gnal guanine nucleotide binding protein, alpha stimulating, olfactory type, transcript variant 2 23.389 23.718 Gpc3 glypican 3 9.250 20.959 Gpld1 glycosylphosphatidylinositol specific phospholipase D1 8.819 13.017 Gspt2 G1 to S phase transition 2 17.939 19.558 Gtdc1 glycosyltransferase-like domain containing 1 12.177 1.895 Gyk glycerol kinase 12.581 7.620 Hdac4 histone deacetylase 4 9.918 6.704 Hdac4 histone deacetylase 4 15.916 7.738 Hdc histidine decarboxylase 9.377 13.881 Hipk1 homeodomain interacting protein kinase 1, transcript variant 1 8.840 8.020 Hist1h2bq histone cluster 1, H2bq 10.107 13.143 Hist2h3c1 histone cluster 2, H3c1 8.278 7.959 Hnmt histamine N-methyltransferase 9.639 12.710 Homer1 homer homolog 1 12.051 6.821 Hrh2 histamine receptor H2, transcript variant 2 13.611 14.718 Hspa14 heat shock protein 14 24.040 5.800 Ifitm5 interferon induced transmembrane protein 5 9.067 5.521 Ifnlr1 interferon lambda receptor 1 8.733 10.889 Il18rap interleukin 18 receptor accessory protein 9.345 11.246 Il1b interleukin 1 beta 12.448 10.559 Il1bos interleukin 1 beta, opposite strand 8.470 13.956 Il1f9 interleukin 1 family, member 9 8.680 19.293 Il20rb interleukin 20 receptor beta 11.046 6.676 Il22ra2 interleukin 22 receptor, alpha 2 18.432 32.280 Inpp1 inositol polyphosphate-1-phosphatase 14.300 18.136 Inpp4a inositol polyphosphate-4-phosphatase, type I , transcript variant 2 8.791 8.006 Inpp5a inositol polyphosphate-5-phosphatase A , transcript variant 2 8.341 8.276 Ipcef1 interaction protein for cytohesin exchange factors 1, transcript variant 1 16.663 17.047 Itgb2l integrin beta 2-like , transcript variant X1 13.003 6.556 Junb jun B proto-oncogene 8.847 9.146 Kcnj2 potassium inwardly-rectifying channel, subfamily J, member 2 11.365 15.889 Kcnn3 potassium intermediate/small conductance calcium-activated channel, subfamily N, member 3 15.318 19.938 Kctd10 potassium channel tetramerisation domain containing 10 , transcript variant 1 12.111 4.144 Klhl2 kelch-like 2, Mayven 9.025 9.826 Klhl24 kelch-like 24 18.238 8.176 Klra17 killer cell lectin-like receptor, subfamily A, member 17 9.121 16.944 Krt86 keratin 86 9.009 10.990 Ksr1 kinase suppressor of ras 1 12.329 16.221 Lamb3 laminin, beta 3 8.587 12.275 Lbp lipopolysaccharide binding protein 8.002 6.014 Letm2 leucine zipper-EF-hand containing transmembrane protein 2 12.589 4.100 Lhx1os LIM homeobox 1, opposite strand 43.807 45.899 Lin28a lin-28 homolog A 9.427 5.524 Lipg lipase, endothelial 14.007 12.990 Lipg lipase, endothelial 28.259 9.507 Lmtk2 lemur tyrosine kinase 2 8.106 7.615 Lpar2 lysophosphatidic acid receptor 2 26.521 8.947 Lrg1 leucine-rich alpha-2-glycoprotein 1 11.077 11.930 Lrrk2 leucine-rich repeat kinase 2 10.550 11.726 Lrrtm3 leucine rich repeat transmembrane neuronal 3 11.410 11.063 Map10 microtubule-associated protein 10 9.539 7.669 Map3k15 mitogen-activated protein kinase kinase kinase 15 8.331 12.939 Map3k9 mitogen-activated protein kinase kinase kinase 9, transcript variant 1 12.264 15.007 Mbd2 methyl-CpG binding domain protein 2 31.405 9.499 Mc3r melanocortin 3 receptor 36.160 36.849 Mctp1 multiple C2 domains, transmembrane 1 11.382 8.759 Mctp2 multiple C2 domains, transmembrane 2 15.752 15.852 Mdm2 transformed mouse 3T3 cell double minute 2, transcript variant 2 8.879 14.524 Med12l mediator complex subunit 12-like 53.247 39.941 Megf9 multiple EGF-like-domains 9 9.469 9.042 Meig1 meiosis expressed gene 1 8.938 8.518 Mfsd6 major facilitator superfamily domain containing 6, transcript variant 2 8.168 7.160 Mgam maltase-glucoamylase 10.909 14.850 Micu1 mitochondrial calcium uptake 1 9.900 9.954 Mmp25 matrix metallopeptidase 25 9.590 16.115 Mmp7 matrix metallopeptidase 7 11.118 10.955 Mmp8 matrix metallopeptidase 8 9.378 13.302 Mpp5 membrane protein, palmitoylated 5 9.858 4.420 Mpzl3 myelin protein zero-like 3 9.913 11.097 Mpzl3 myelin protein zero-like 3 11.715 11.450 Mrgpra2b MAS-related GPR, member A2B 8.010 11.034 Mrgpra5 MAS-related GPR, member A5 9.567 18.878 Mrgpra6 MAS-related GPR, member A6 8.515 11.941 Mrgpra7 MAS-related GPR, member A7 11.023 14.890 Mtus1 mitochondrial tumor suppressor 1 13.921 23.956 Mustn1 musculoskeletal, embryonic nuclear protein 1 15.992 27.427 Mxi1 Max interacting protein 1 , transcript variant X6 13.745 7.873 Nabp1 nucleic acid binding protein 1 9.004 10.192 Ncf2 neutrophil cytosolic factor 2 18.961 14.958 Ncoa2 nuclear receptor coactivator 2, transcript variant a 17.493 7.169 Nhsl2 NHS-like 2 8.219 6.942 Nlrp12 NLR family, pyrin domain containing 12 25.614 24.194 Nos1ap nitric oxide synthase 1 adaptor protein , transcript variant 2 12.958 9.599 Oas1b 2-5 oligoadenylate synthetase 1B 19.323 6.620 Olfm4 olfactomedin 4 10.946 10.880 Olfr1349 olfactory receptor 1349 9.846 3.863 Olfr1417 olfactory receptor 1417 13.024 7.968 Olfr1466 olfactory receptor 1466 14.424 11.051 Olfr849 olfactory receptor 849 9.316 28.196 Otud3 OTU domain containing 3, transcript variant X2 8.770 7.630 P2ry1 purinergic receptor P2Y, G-protein coupled 1, transcript variant 1 8.168 9.478 Panct2 pluripotency-associated noncoding transcript 2, transcript variant X1 17.327 8.383 Pde7b phosphodiesterase 7B 18.180 20.778 Pdzd3 PDZ domain containing 3 21.265 20.618 Pfkfb4 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 12.179 13.681 Phf20l1 PHD finger protein 20-like 1 , transcript variant X14 15.018 15.839 Phf21a PHD finger protein 21A, transcript variant 2 10.244 24.217 Phip pleckstrin homology domain interacting protein 29.758 1.932 Pigb phosphatidylinositol glycan anchor biosynthesis, class B 16.864 16.798 Pik3r5 phosphoinositide-3-kinase, regulatory subunit 5, p101 30.120 14.807 Pikfyve phosphoinositide kinase, FYVE finger containing 10.605 5.684 Pip5k1b phosphatidylinositol-4-phosphate 5-kinase, type 1 beta 8.716 10.302 Pknox2 Pbx/knotted 1 homeobox 2, transcript variant 2 12.811 9.902 Plekhm1 pleckstrin homology domain containing, family M member 1 11.539 6.312 Plekhm3 pleckstrin homology domain containing, family M, member 3 9.615 4.961 Plekhs1 pleckstrin homology domain containing, family S member 1, transcript variant 1 13.916 14.381 Plin5 perilipin 5, transcript variant 2 11.021 17.915 Pnpla1 patatin-like phospholipase domain containing 1 9.060 9.269 Pqlc1 PQ loop repeat containing 1, transcript variant 2 11.614 14.849 Pram1 PML-RAR alpha-regulated adaptor molecule 1 10.168 11.604 Prkag2 protein kinase, AMP-activated, gamma 2 non-catalytic subunit 8.326 12.434 Prkcg protein kinase C, gamma, transcript variant 1 14.755 11.044 Prok2 Bv8 variant 2 precursor 10.199 13.551 Psip1 PC4 and SFRS1 interacting protein 1 11.210 12.251 Rab11fip4 RAB11 family interacting protein 4 11.349 13.261 Rab23 RAB23, member RAS oncogene family, transcript variant 1 10.098 4.778 Rb1cc1 RB1-inducible coiled-coil 1 19.084 15.668 Rbbp6 retinoblastoma binding protein 6, transcript variant 2 20.882 7.098 Rbm25 RNA binding motif protein 25 8.804 10.561 Retnlg resistin like gamma 9.055 12.880 Rgs3 regulator of G-protein signaling 3, transcript variant 2 9.083 7.493 Rnaset2b ribonuclease T2B 14.107 10.453 Rnf125 ring finger protein 125 12.760 7.911 Rnf144a ring finger protein 144A, transcript variant 2 12.287 20.428 Rnf38 ring finger protein 38, transcript variant 1 8.733 14.660 Rnf41 ring finger protein 41, transcript variant 2 11.126 19.238 Rspry1 ring finger and SPRY domain containing 1 8.624 16.347 S1pr4 sphingosine-1-phosphate receptor 4 8.896 6.878 Saa2 serum amyloid A 2 9.784 9.808 Saa3 serum amyloid A 3 10.884 24.495 Scai suppressor of cancer cell invasion 15.634 7.799 Scgb3a1 secretoglobin, family 3A, member 1, transcript variant 2 9.379 15.563 Scnn1a sodium channel, nonvoltage-gated 1 alpha 10.376 10.121 Scrg1 scrapie responsive gene 1 35.595 18.127 Sema4f sema domain, immunoglobulin domain, TM domain, and short cytoplasmic domain (Sema4f), transcript variant10.147 1 7.130 Serpinf2 serine peptidase inhibitor, clade F, member 2 14.908 11.345 Sgms1 sphingomyelin synthase 1 18.903 7.372 Sidt2 SID1 transmembrane family, member 2, transcript variant 2 8.658 14.312 Siglecf sialic acid binding Ig-like lectin F, transcript variant 1 12.156 16.555 Slc16a3 solute carrier family 16, member 3 22.331 8.227 Slc25a2 solute carrier family 25 11.791 11.890 Slc25a27 solute carrier family 25, member 27 10.862 2.881 Slc27a4 solute carrier family 27, member 4 26.768 26.319 Slc27a6 solute carrier family 27, member 6 16.692 11.986 Slc2a3 solute carrier family 2, member 3 8.923 9.627 Slc35a5 solute carrier family 35, member A5 8.400 11.819 Slc36a3 solute carrier family 36, member 3 14.707 17.314 Slc7a11 solute carrier family 7, member 11 12.398 17.276 Slco3a1 solute carrier organic anion transporter family, member 3a1 8.100 5.308 Slco4c1 solute carrier organic anion transporter family, member 4C1 70.776 25.135 Slfn5 schlafen 5 8.077 17.000 Smarcd2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 2 12.187 10.144 Smpd5 sphingomyelin phosphodiesterase 5 8.005 6.174 Spats2 spermatogenesis associated, serine-rich 2 9.297 5.023 Sprr2h small proline-rich protein 2H 12.089 5.178 Steap1 six transmembrane epithelial antigen of the prostate 1 17.427 5.613 Stra6 stimulated by retinoic acid gene 6, transcript variant 2 10.391 23.611 Syne1 spectrin repeat containing, nuclear envelope 1, transcript variant 1 9.181 10.277 Synj1 synaptojanin 1 17.966 11.424 Synpo synaptopodin 9.993 16.371 Tas2r113 taste receptor, type 2, member 113 14.813 21.713 Tbc1d14 TBC1 domain family, member 14, transcript variant 2 8.973 17.269 Tbc1d31 TBC1 domain family, member 31, transcript variant X1 16.560 12.426 Tex14 testis expressed gene 14, transcript variant 1 15.217 20.082 Thap6 THAP domain containing 6 11.251 9.642 Tmbim6 transmembrane BAX inhibitor motif containing 6 10.045 8.992 Tmcc1 transmembrane and coiled coil domains 1 12.196 8.357 Tmem154 transmembrane protein 154 13.134 12.499 Tmem164 transmembrane protein 164, transcript variant 3 11.905 17.481 Tnfaip6 tumor necrosis factor alpha induced protein 6 8.348 11.588 Tnrc6b trinucleotide repeat containing 6b, transcript variant 2 11.176 8.167 Trem1 triggering receptor expressed on myeloid cells 1 10.401 15.772 Trp53inp2 transformation related protein 53 inducible nuclear protein 2 12.635 8.853 Ttc7 tetratricopeptide repeat domain 7 42.296 10.551 Ttll3 tubulin tyrosine ligase-like family, member 3 , transcript variant 2 9.356 18.674 Ulk1 unc-51 like kinase 1 27.174 21.861 Ush1c Usher syndrome 1C, transcript variant b4 11.332 29.624 Vps4b vacuolar protein sorting 4b 16.019 11.151 Vsig10l ZV-set and immunoglobulin domain containing 10 like 8.527 13.157 Wnt10a wingless-type MMTV integration site family 8.501 1.691 Xxylt1 xyloside xylosyltransferase 1 8.649 8.544 Zcchc12 zinc finger, CCHC domain containing 12 8.841 14.729 Zfand4 zinc finger, AN1-type domain 4, transcript variant 1 17.724 17.668 Zfp473 zinc finger protein 473, transcript variant 1 10.287 13.661 Zfp655 zinc finger protein 655, transcript variant 2 11.912 4.529 Zfp78 zinc finger protein 78, transcript variant 2 13.889 10.229 Zyx zyxin, transcript variant 2 12.101 12.827

The list of genes expressed in ALDH-negative cells in which the levels were higher at ZT12 than at ZT0

Fold changes GeneSymbol Description ALDH (-) > ALDH (+) ZT12/ZT0 Apol8 apolipoprotein L 8 10.810 1.681 Atg9b autophagy related 9B 10.842 2.856 ATP8 mitochondrially encoded ATP synthase 8 9.559 4.967 Atp9a ATPase, class II, type 9A , transcript variant 1 12.148 2.245 B9d1 B9 protein domain 1 9.795 1.947 Bcl7a B cell CLL/lymphoma 7A 13.265 6.631 Blm Bloom syndrome, RecQ helicase-like , transcript variant 1 14.264 13.729 Bmp1 bone morphogenetic protein 1 , transcript variant 1 14.915 3.357 Bmp7 bone morphogenetic protein 7 13.763 1.952 Bok BCL2-related ovarian killer 11.207 1.681 C1qa complement component 1, q subcomponent, alpha polypeptide 9.479 10.375 C1qb complement component 1, q subcomponent, beta polypeptide 8.506 8.948 C1qc complement component 1, q subcomponent, C chain 8.012 6.911 Cabp5 calcium binding protein 5 14.130 14.309 Cald1 caldesmon 1 10.059 2.316 Car7 carbonic anhydrase 7 , transcript variant 1 8.579 6.765 Car9 carbonic anhydrase 9 9.810 1.932 Casc4 cancer susceptibility candidate 4 , transcript variant 2 11.953 1.751 Catsper4 cation channel, sperm associated 4, transcript variant 1 14.591 7.726 Cblc Casitas B-lineage lymphoma c, transcript variant 2 8.690 1.959 Cbx6 chromobox 6 9.015 1.791 Cc2d2a coiled-coil and C2 domain containing 2A 8.670 2.057 Ccbe1 collagen and calcium binding EGF domains 1 12.447 1.642 Ccdc172 coiled-coil domain containing 172 10.840 5.288 Ccdc68 coiled-coil domain containing 68 12.268 2.191 Ccl1 chemokine ligand 1 53.333 54.225 Ccl12 chemokine ligand 12 11.978 7.911 Ccnd1 cyclin D1 12.967 2.767 Cd19 CD19 antigen 17.836 49.949 Cd209g CD209g antigen 27.133 10.807 Cd3g CD3 antigen, gamma polypeptide 10.380 26.425 Cd5l CD5 antigen-like 12.286 3.588 Cd72 CD72 antigen, transcript variant 2 8.187 9.646 Cd79b CD79B antigen 25.788 63.031 Cdc42ep1 CDC42 effector protein 1 13.248 2.002 Cdcp1 CUB domain containing protein 1 20.445 19.693 Cep170b centrosomal protein 170B 10.647 1.574 Cgn cingulin , transcript variant 1 13.716 1.717 Chchd10 coiled-coil-helix-coiled-coil-helix domain containing 10 10.027 3.856 Chst3 carbohydrate sulfotransferase 3 16.239 11.571 Cldn3 claudin 3 22.853 2.733 Clec2f C-type lectin domain family 2, member f 24.110 1.574 Clu clusterin 10.476 2.784 Col16a1 collagen, type XVI, alpha 1 10.184 2.208 Col18a1 collagen, type XVIII, alpha 1 16.362 2.717 Col6a1 collagen, type VI, alpha 1 10.284 3.275 Col7a1 collagen, type VII, alpha 1 8.075 2.893 Col8a1 collagen, type VIII, alpha 1 10.188 2.738 Cops4 COP9 homolog, subunit 4 8.286 7.638 Cpe carboxypeptidase E 12.677 2.064 Crym crystallin, mu 26.231 4.888 Ctnnal1 catenin, alpha-like 1 13.602 1.521 Cts7 cathepsin 7 8.016 6.048 Cttn cortactin, transcript variant 2 11.993 1.933 Cyb561 cytochrome b-561 10.736 1.816 Cyp2r1 cytochrome P450, family 2, subfamily r, polypeptide 1, transcript variant 1 12.939 6.939 Cyp4a31 cytochrome P450, family 4, subfamily a, polypeptide 31, transcript variant 2 102.671 94.988 Dact2 dapper homolog 2, antagonist of beta-catenin 9.620 3.205 Dcaf12l2 DDB1 and CUL4 associated factor 12-like 2 12.042 13.230 Ddx25 DEAD Asp-Glu-Ala-Asp box polypeptide 25 16.219 16.979 Dmrtb1 DMRT-like family B with proline-rich C-terminal, 1 22.415 7.265 Dnajc22 DnaJ homolog, subfamily C 8.084 1.698 Dst dystonin , transcript variant 2 12.282 4.011 Efna1 ephrin A1, transcript variant 1 13.708 1.834 Efna2 ephrin A2 14.230 28.252 Efna5 ephrin A5 , transcript variant 1 10.779 3.555 Elovl6 ELOVL family member 6, elongation of long chain fatty acids 13.911 7.852 Emp2 epithelial membrane protein 2 12.836 1.807 Epb4.1l1 erythrocyte protein band 4.1-like 1, transcript variant 3 10.066 3.874 Epcam epithelial cell adhesion molecule 11.492 3.134 Epha2 Eph receptor A2 10.886 2.012 Ephb4 Eph receptor B4, transcript variant 1 13.919 2.181 Epn2 epsin 2, transcript variant 1 8.600 2.357 Erbb2 v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene 19.982homolog 2.242 Ercc1 excision repair cross-complementing rodent repair deficiency, complementation group 1 (Ercc1), transcript10.827 variant 1 2.215

Etv4 ets variant 4 14.804 1.583 Eva1c eva-1 homolog C, transcript variant 2 9.647 1.912 Eya2 eyes absent 2 homolog , transcript variant 1 10.186 2.276 Fam213a family with sequence similarity 213 11.288 1.871 Fam83h family with sequence similarity 83, member H , transcript variant 2 13.536 2.307 Fat1 FAT tumor suppressor homolog 1 9.779 2.012 Fblim1 filamin binding LIM protein 1, transcript variant 2 12.988 1.860 Fbln2 fibulin 2, transcript variant 1 10.479 2.802 Fcmr Fas apoptotic inhibitory molecule 3 17.271 31.773 Fgf2 fibroblast growth factor 2 11.793 6.113 Fgfbp1 fibroblast growth factor binding protein 1, transcript variant 1 25.675 4.508 Fhl2 four and a half LIM domains 2, transcript variant 1 14.604 2.048 Flywch2 FLYWCH family member 2 9.975 2.159 Fxyd3 FXYD domain-containing ion transport regulator 3 8.797 1.566 Fxyd6 FXYD domain-containing ion transport regulator 6 15.377 5.938 Gas6 growth arrest specific 6 9.512 3.103 Gata3 GATA binding protein 3 13.521 2.492 Gcat glycine C-acetyltransferase 2-amino-3-ketobutyrate-coenzyme A ligase, transcript variant 1 9.149 3.139 Gcm1 glial cells missing homolog 1 8.382 10.025 Gimap1 GTPase, IMAP family member 1 , transcript variant 1 10.445 15.455 Gimap3 GTPase, IMAP family member 3 11.640 33.307 Gimap4 GTPase, IMAP family member 4 , transcript variant 1 11.980 22.319 Gimap5 GTPase, IMAP family member 5 13.215 8.904 Gimap6 GTPase, IMAP family member 6 11.813 11.748 Gja1 gap junction protein, alpha 1 13.125 2.163 Gjb3 gap junction protein, beta 3 , transcript variant 1 18.587 3.165 Gjb4 gap junction protein, beta 4 13.072 1.939 Gjc1 gap junction protein, gamma 1, transcript variant 1 19.330 1.534 Glrp1 glutamine repeat protein 1 13.591 2.024 Gpatch4 G patch domain containing 4, transcript variant 1 9.059 2.865 Gpx8 glutathione peroxidase 8 9.155 2.134 Grb7 growth factor receptor bound protein 7 13.456 2.564 Gstm5 glutathione S-transferase 9.666 1.752 Gzma granzyme A 24.782 191.471 Gzmb granzyme B 12.686 43.454 Gzmc granzyme C 28.687 355.046 Gzmd granzyme D 14.200 62.604 Gzme granzyme E 13.582 145.984 Gzmg granzyme G 13.603 26.733 H19 H19, imprinted maternally expressed transcript , transcript variant 1 12.142 1.593 Hba-a1 hemoglobin alpha, adult chain 1 215.067 193.975 Hba-a2 hemoglobin alpha, adult chain 2 214.990 195.267 Hbb-b1 hemoglobin, beta adult major chain 801.504 245.319 Hbb-b2 hemoglobin, beta adult minor chain 375.365 281.512 Hbb-bt hemoglobin, beta adult t chain 313.599 272.351 Herc2 hect domain and RCC1-like domain 2 11.759 12.304 Hmga2 high mobility group AT-hook 2 10.178 2.355 Hmgn1 high mobility group nucleosomal binding domain 1 9.016 3.255 Hoxa10 homeobox A10, transcript variant 1 8.851 1.715 Hoxa3 homeobox A3 9.529 2.014 Hoxa6 homeobox A6 12.785 2.743 Hspg2 perlecan heparan sulfate proteoglycan 2 9.974 3.458 Htra1 HtrA serine peptidase 1 10.292 2.228 Ick intestinal cell kinase , transcript variant 1 8.172 2.668 Ier5l immediate early response 5-like 10.421 3.475 Ifna11 interferon alpha 11 8.512 5.758 Igll1 immunoglobulin lambda-like polypeptide 1 56.534 55.838 Ikzf3 IKAROS family zinc finger 3 10.945 42.995 Il2rb interleukin 2 receptor, beta chain 12.823 38.359 Iqgap3 IQ motif containing GTPase activating protein 3 8.067 20.144 Itga1 integrin alpha 1 11.722 4.665 Itga3 integrin alpha 3, transcript variant 1 18.158 3.319 Itga6 integrin alpha 6 , transcript variant 1 10.003 2.819 Itgb4 integrin beta 4, transcript variant 1 14.147 3.552 Itpr3 inositol 1,4,5-triphosphate receptor 3 8.222 2.162 Kank3 KN motif and ankyrin repeat domains 3 8.332 3.070 Kcnk1 potassium channel, subfamily K, member 1 12.206 2.071 Kcnn4 potassium intermediate/small conductance calcium-activated channel, subfamily N, member 4, transcript13.127 variant 2 2.799 Kcnq1 potassium voltage-gated channel subfamily Q member 1 variant 4 10.759 21.367 Kdf1 keratinocyte differentiation factor 1 , transcript variant 1 9.383 1.589 Kirrel kin of IRRE like, transcript variant 1 10.723 2.432 Kirrel3 mRNA for mKIAA1867 protein 12.351 16.814 Klc3 kinesin light chain 3, transcript variant 2 9.319 2.113 Klk8 kallikrein related-peptidase 8 8.891 3.052 Klra1 killer cell lectin-like receptor, subfamily A, member 1 20.150 11.940 Klra16 killer cell lectin-like receptor, subfamily A, member 16 22.468 11.138 Klrb1c killer cell lectin-like receptor subfamily B member 1C, transcript variant 1 20.354 19.913 Klrg1 killer cell lectin-like receptor subfamily G, member 1 12.902 7.597 Krt14 keratin 14 33.505 6.826 Krt18 keratin 18 21.398 2.091

Krt19 keratin 19 16.717 2.817 Krt42 keratin 42 12.824 3.336 Krt7 keratin 7 10.570 3.549 Krt8 keratin 8 20.497 3.241 Lad1 ladinin 19.205 2.686 Lama3 laminin, alpha 3 17.106 2.086 Lama5 laminin, alpha 5 12.006 2.206 Lamb1 laminin B1 10.460 2.113 Lamc1 laminin, gamma 1 12.650 2.343 Lamc2 laminin, gamma 2 26.853 2.811 Lck lymphocyte protein tyrosine kinase, transcript variant 2 12.681 24.962 Lef1 lymphoid enhancer binding factor 1, transcript variant 1 11.261 25.586 Lgals1 lectin, galactose binding, soluble 1 9.604 2.295 Lhfp lipoma HMGIC fusion partner 10.575 1.855 Lmna lamin A , transcript variant 2 11.089 2.365 Lncbate1 MONTH14_08_P15.x1 13.637 16.849 Lrfn4 leucine rich repeat and fibronectin type III domain containing 4 10.444 2.291 Lrig1 leucine-rich repeats and immunoglobulin-like domains 1 9.583 1.777 Lrrn2 leucine rich repeat protein 2, neuronal 10.917 10.637 Lsamp limbic system-associated membrane protein, transcript variant X1 20.256 28.876 Ltbp1 latent transforming growth factor beta binding protein 1 , transcript variant 1 11.024 2.248 Ltbp2 latent transforming growth factor beta binding protein 2 11.236 1.784 Ly6g6e lymphocyte antigen 6 complex, locus G6E, transcript variant X2 31.448 8.914 Lypd3 Ly6/Plaur domain containing 3 15.047 2.895 Lypd6b LY6/PLAUR domain containing 6B 13.702 21.607 Lzts3 leucine zipper, putative tumor suppressor family member 3, transcript variant 1 12.758 12.242 Map1b microtubule-associated protein 1B 13.713 3.389 Mapk12 mitogen-activated protein kinase 12 9.997 1.518 Mapt microtubule-associated protein tau, transcript variant 4 13.729 21.969 Mcpt1 mast cell protease 1 17.771 11.073 Mcpt2 mast cell protease 2 9.105 9.102 Megf6 multiple EGF-like-domains 6 11.145 1.560 Mfge8 milk fat globule-EGF factor 8 protein, transcript variant 1 8.604 2.334 Mid1 midline 1, transcript variant 4 55.713 27.497 Mmp12 matrix metallopeptidase 12 12.326 5.169 Morc4 microrchidia 4, transcript variant B 10.564 1.996 Moxd1 monooxygenase, DBH-like 1 8.705 2.516 Mrgprg MAS-related GPR, member G 37.642 18.391 Mrps6 mitochondrial ribosomal protein S6 11.149 2.814 Ms4a4b membrane-spanning 4-domains, subfamily A, member 4B 9.924 13.250 Ms4a7 membrane-spanning 4-domains, subfamily A, member 7, transcript variant 3 8.441 2.843 Msln mesothelin 30.078 3.186 Msmp microseminoprotein, prostate associated 23.660 7.338 Mtap methylthioadenosine phosphorylase 8.912 2.127 Myh7 myosin, heavy polypeptide 7, cardiac muscle, beta 11.231 7.678 Myl4 myosin, light polypeptide 4 16.015 13.670 Nckap1 NCK-associated protein 1, transcript variant 1 11.896 1.980 Ncr1 natural cytotoxicity triggering receptor 1 10.333 15.984 ND1 mitochondrially encoded NADH dehydrogenase 1 13.832 6.996 ND2 mitochondrially encoded NADH dehydrogenase 2 10.819 6.814 ND3 mitochondrially encoded NADH dehydrogenase 3 8.871 4.145 ND4L mitochondrially encoded NADH dehydrogenase 4L 11.393 6.612 ND5 mitochondrially encoded NADH dehydrogenase 5 12.182 8.505 Nenf neuron derived neurotrophic factor 10.983 2.746 Nepn nephrocan 19.441 5.701 Nfib nuclear factor I/B , transcript variant 1 11.220 3.546 Nipsnap1 4-nitrophenylphosphatase domain and non-neuronal SNAP25-like protein homolog 1 9.806 2.753 Nkg7 natural killer cell group 7 sequence 10.006 15.212 Notch1 notch 1 10.013 11.779 Npdc1 neural proliferation, differentiation and control 1 10.921 2.521 Nr1i3 nuclear receptor subfamily 1, group I, member 3, transcript variant 1 18.371 9.802 Nudt5 nudix (nucleoside diphosphate linked moiety X)-type motif 5 19.117 15.249 Oaf OAF homolog 11.347 1.815 Olfr1107 olfactory receptor 1107 22.410 25.890 Olfr1500 olfactory receptor 1500 13.538 11.765 Opcml opioid binding protein/cell adhesion molecule-like 30.650 18.508 Otop1 otopetrin 1 14.440 2.412 Pacsin3 protein kinase C and casein kinase substrate in neurons 3, transcript variant 4 12.760 1.907 Park2 Parkinson disease 2, parkin 34.464 8.163 Pcbp3 polyrC binding protein 3 8.870 1.722 Pcbp4 polyrC binding protein 4 11.173 2.726 Pcolce2 procollagen C-endopeptidase enhancer 2 10.678 1.888 Pdcd1 programmed cell death 1 9.835 13.801 Pdgfa platelet derived growth factor, alpha 11.345 2.555 Pdlim4 PDZ and LIM domain 4 8.435 6.391 Perp PERP, TP53 apoptosis effector 18.620 3.393 Pf4 platelet factor 4 9.255 3.862 Phgdh 3-phosphoglycerate dehydrogenase 8.836 5.196 Phyhipl phytanoyl-CoA hydroxylase interacting protein-like 16.914 17.194 Pick1 protein interacting with C kinase 1 , transcript variant 1 14.650 13.080

Pik3ca phosphatidylinositol 3-kinase, catalytic, alpha polypeptide 10.264 5.764 Pkp2 plakophilin 2 13.873 1.791 Plac9a placenta specific 9a 9.637 2.475 Platr17 cDNA sequence BC033916 10.373 9.166 Plcd3 phospholipase C, delta 3 10.056 2.830 Pls3 plastin 3, transcript variant 1 8.847 2.006 Pmepa1 prostate transmembrane protein, androgen induced 1 8.774 4.150 Pnma2 paraneoplastic antigen MA2 9.668 7.856 Pomgnt2 protein O-linked mannose beta 1,4-N-acetylglucosaminyltransferase 2, transcript variant 1 10.419 1.842 Pou2af1 POU domain, class 2, associating factor 1 56.844 42.900 Pou4f1 POU domain, class 4, transcription factor 1 18.117 15.331 Ppap2c phosphatidic acid phosphatase type 2C, transcript variant 1 9.279 2.366 Ppl periplakin 12.848 1.877 Prdx2 peroxiredoxin 2 9.203 2.906 Prex2 phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 2, transcript variant 1 8.192 7.090 Prg2 proteoglycan 2, bone marrow 17.358 16.645 Prickle1 prickle homolog 1 8.291 7.337 Prkcdbp protein kinase C, delta binding protein 12.490 2.227 Prkg2 protein kinase, cGMP-dependent, type II 14.632 2.008 Prmt2 protein arginine N-methyltransferase 2, transcript variant 2 9.098 2.275 Prr3 proline-rich polypeptide 3, transcript variant 1 10.463 5.914 Pthlh parathyroid hormone-like peptide 12.316 2.338 Ptk2 PTK2 protein tyrosine kinase 2, transcript variant 2 11.280 1.991 Ptms parathymosin 16.049 11.230 Ptprk protein tyrosine phosphatase 9.960 1.671 Ptrf polymerase I and transcript release factor 14.438 2.760 Ptx4 pentraxin 4, transcript variant 1 8.483 16.760 Pxdc1 PX domain containing 1 9.008 1.936 Pxdn peroxidasin homolog 9.748 1.606 Rab34 RAB34, member RAS oncogene family, transcript variant 1 10.938 1.612 Rabgap1 RAB GTPase activating protein 1, transcript variant 2 16.696 23.377 Rai14 retinoic acid induced 14, transcript variant 1 8.564 2.021 Rapgef3 Rap guanine nucleotide exchange factor 3, transcript variant 2 10.644 2.357 Rcn1 reticulocalbin 1 8.251 2.477 Rgs12 regulator of G-protein signaling 12, transcript variant 1 7.986 1.890 Rhbdf1 rhomboid family 1, transcript variant 1 10.108 1.747 Rhox4g reproductive homeobox 4G 8.235 1.593 Rsad1 radical S-adenosyl methionine domain containing 1 13.123 2.911 S100a10 S100 calcium binding protein A10 8.704 3.159 Sbpl spermine binding protein-like 8.403 17.648 Scarf2 scavenger receptor class F, member 2 10.300 2.421 Scn5a sodium channel, voltage-gated, type V, transcript variant 1 10.619 1.695 Scx scleraxis 8.363 2.530 Sema3f sema domain, immunoglobulin domain, short basic domain, secreted, 3F 15.044 2.193 Serinc2 serine incorporator 2, transcript variant 2 14.565 2.772 Serpinb5 serine peptidase inhibitor, clade B, member 5 72.223 3.255 Sez6 seizure related gene 6 18.792 11.234 Shank2 SH3/ankyrin domain gene 2 15.645 40.696 Shc4 SHC (Src homology 2 domain containing family, member 4 17.253 15.521 Skap1 src family associated phosphoprotein 1, transcript variant 1 9.492 15.494 Skint4 selection and upkeep of intraepithelial T cells 4 8.709 11.544 Slc12a2 solute carrier family 12 9.479 1.776 Slc22a12 solute carrier family 22, member 12 73.925 31.006 Slc26a1 solute carrier family 26 , member 1 12.049 7.001 Slc29a1 solute carrier family 29, member 1, transcript variant 1 9.180 3.074 Slc4a1 solute carrier family 4, member 1 20.069 20.286 Slco2a1 solute carrier organic anion transporter family, member 2a1 21.777 15.969 Smarcd3 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member10.188 3 1.882 Smo smoothened homolog 8.824 2.164 Smyd2 SET and MYND domain containing 2 9.630 2.889 Snca synuclein, alpha, transcript variant 1 20.463 16.444 Snora74a small nucleolar RNA, H/ACA box 74A 35.066 25.712 Snx29 sorting nexin 29, transcript variant 1 8.489 7.010 Sox4 SRY-box 4 11.423 4.392 Sox9 SRY-box 9 14.135 2.843 Spaca6 sperm acrosome associated 6 12.155 2.888 Spag9 sperm associated antigen 9 10.404 2.723 Spns2 spinster homolog 2, transcript variant 1 10.869 2.260 Sppl3 signal peptide peptidase 3 10.497 1.943 Sptbn1 spectrin beta, non-erythrocytic 1 22.806 4.861 Srp54b signal recognition particle 54B 13.097 20.503 Ssty1 spermiogenesis specific transcript on the Y 1 8.932 18.869 St14 suppression of tumorigenicity 14 14.485 5.489 St6galnac1 ST6 alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3-N-acetylgalactosaminide alpha-2,6-sialyltransferase11.862 1 3.434 St7l suppression of tumorigenicity 7-like 9.334 15.779 Steap4 STEAP family member 4 17.275 1.542 Sult2b1 sulfotransferase family, cytosolic, 2B, member 1 17.777 7.090 Svil supervillin 10.799 2.714 Taf7 TAF7 RNA polymerase II, TATA box binding protein -associated factor 21.242 6.124 Tbpl1 TATA box binding protein-like 1 11.076 27.341

Tbx22 T-box 22 24.546 30.632 Tcea3 transcription elongation factor A, 3 8.162 2.713 Tcf7 transcription factor 7, T cell specific 13.341 4.201 Tdgf1 teratocarcinoma-derived growth factor 1 15.159 20.081 Tenm4 teneurin transmembrane protein 4 8.274 4.801 Tfap2a transcription factor AP-2 10.980 1.799 Tgfb3 transforming growth factor, beta 3 8.408 2.335 Thy1 thymus cell antigen 1, theta 12.561 21.671 Tm4sf1 transmembrane 4 superfamily member 1 12.433 2.132 Tmem132a transmembrane protein 132A 25.959 4.989 Tmem171 transmembrane protein 171 9.671 1.544 Tmem184a transmembrane protein 184a, transcript variant 1 8.913 1.552 Tmem238 transmembrane protein 238 38.952 1.873 Tmem52b transmembrane protein 52B 36.716 11.845 Tmem54 transmembrane protein 54, transcript variant 1 18.767 2.659 Tmem55a transmembrane protein 55A 16.603 14.497 Tmem79 transmembrane protein 79 8.251 1.761 Tmprss11e transmembrane protease, serine 11e 14.098 2.351 Tmsb10 thymosin, beta 10 12.149 24.407 Tnfrsf19 tumor necrosis factor receptor superfamily, member 19, transcript variant 1 14.022 7.591 Tnk1 tyrosine kinase 9.582 1.802 Tnnt2 troponin T2, cardiac, transcript variant 9 16.236 2.644 Tns4 tensin 4 13.068 2.707 Tpm1 tropomyosin 1, alpha, transcript variant Tpm1.1 9.689 2.567 Trib2 tribbles homolog 2 11.303 1.798 Trp53rkb transformation related protein 53 regulating kinase, transcript variant X1 13.965 13.109 Trpm1 transient receptor potential cation channel, subfamily M, member 1, transcript variant 2 10.045 9.316 Trub1 TruB pseudouridine synthase homolog 1, transcript variant 2 15.818 2.793 Tspan4 tetraspanin 4, transcript variant 1 11.530 2.475 Tssk5 testis-specific serine kinase 5 10.368 25.951 Ttf2 transcription termination factor, RNA polymerase II 11.677 3.732 Txk TXK tyrosine kinase, transcript variant 17.285 7.182 Tyro3 TYRO3 protein tyrosine kinase 3, transcript variant 2 17.037 1.736 Uaca uveal autoantigen with coiled-coil domains and ankyrin repeats 10.702 2.921 Unc5b unc-5 homolog B 10.739 2.205 Urah urate 5-hydroxyiso-hydrolase 13.724 2.001 Vangl1 vang-like 1 9.408 2.955 Vegfa vascular endothelial growth factor A, transcript variant 1 28.028 13.543 Vpreb1 pre-B lymphocyte gene 1 40.128 24.898 Vpreb2 pre-B lymphocyte gene 2 11.657 14.253 Vpreb3 pre-B lymphocyte gene 3 149.852 123.471 Wdr60 WD repeat domain 60 10.230 1.639 Wfdc2 WAP four-disulfide core domain 2 19.337 2.080 Wnt7a wingless-type MMTV integration site family, member 7A 11.418 1.546 Wnt7b wingless-type MMTV integration site family, member 7B, transcript variant 2 11.407 2.128 Wwtr1 WW domain containing transcription regulator 1, transcript variant 2 8.559 2.138 Xcl1 chemokine ligand 1 30.012 43.393 Yap1 yes-associated protein 1, transcript variant 1 9.948 1.883 Zdhhc22 zinc finger, DHHC-type containing 22 17.885 11.642