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Home , African clawed frog, Aminohydrolase, ARNTL2, CACNA2D1, CNBP, COPA (gene)

Antibodies gene_name sku Entry_Name Protein_Names Organism Length Identity ARP31175_P050 Q6DE14_XENLA E2f4‐prov laevis () 375 92.00% Xenopus tropicalis () e2f4 ARP31175_P050 B0JZ97_XENTR E2f4 protein ( tropicalis) 374 92.00% General 2F, polypeptide 2, Xenopus tropicalis (Western clawed frog) LOC511494 ARP31437_P050 Q6P8B7_XENTR 30kDa (Silurana tropicalis) 264 85.00% General transcription factor IIF subunit 2 (EC 3.6.4.12) (ATP‐dependent helicase ) (Transcription initiation factor IIF subunit beta) (TFIIF‐beta) (Transcription initiation LOC511494 ARP31437_P050 T2FB_XENLA factor RAP30) Xenopus laevis (African clawed frog) 264 85.00% ORF Names:PANDA_000462 EMBL EFB13877.1OrganismAiluropoda melanoleuca (Giant panda) ARP31939_P050 Q8AVU3_XENLA MGC52825 protein Xenopus laevis (African clawed frog) 212 92.00% ORF Names:PANDA_000462 EMBL EFB13877.1OrganismAiluropoda Xenopus tropicalis (Western clawed frog) melanoleuca (Giant panda) ARP31939_P050 Q6P7M9_XENTR High‐mobility group box 2 (Silurana tropicalis) 212 92.00% ORF Names:PANDA_000462 EMBL EFB13877.1OrganismAiluropoda melanoleuca (Giant panda) ARP31939_P050 Q32NS7_XENLA MGC52825 protein Xenopus laevis (African clawed frog) 211 92.00% ORF Names:PANDA_000462 EMBL EFB13877.1OrganismAiluropoda melanoleuca (Giant panda) ARP31939_P050 Q91764_XENLA HMG‐X protein Xenopus laevis (African clawed frog) 212 84.00% ORF Names:PANDA_000462 EMBL EFB13877.1OrganismAiluropoda melanoleuca (Giant panda) ARP31939_P050 Q7ZXK5_XENLA MGC52578 protein Xenopus laevis (African clawed frog) 212 84.00% Agpat5 ARP47429_P050 Q6NS16_XENLA MGC78843 protein Xenopus laevis (African clawed frog) 397 85.00% ARP31200_P050 Q6NS16_XENLA MGC78843 protein Xenopus laevis (African clawed frog) 397 85.00% ARP47492_P050 Q98SF3_XENLA Lhx7 protein (Fragment) Xenopus laevis (African clawed frog) 74 85.00% ARP47492_P050 Q6PF48_XENLA MGC68912 protein Xenopus laevis (African clawed frog) 282 85.00% Xenopus tropicalis (Western clawed frog) ARP47492_P050 Q28CD2_XENTR LIM 7/8 (LIM homeobox 8) (Silurana tropicalis) 374 85.00% Lhx6 ARP31999_P050 Q98SF3_XENLA Lhx7 protein (Fragment) Xenopus laevis (African clawed frog) 74 85.00% Lhx6 ARP31999_P050 Q6PF48_XENLA MGC68912 protein Xenopus laevis (African clawed frog) 282 85.00% Xenopus tropicalis (Western clawed frog) Lhx6 ARP31999_P050 Q28CD2_XENTR LIM homeobox 7/8 (LIM homeobox 8) (Silurana tropicalis) 374 85.00% XSu(H)1 ARP31121_P050 A3KMT5_XENLA XSu(H)1 protein Xenopus laevis (African clawed frog) 487 92.00% XSu(H)1 ARP31121_P050 SUH_XENLA Isoform 2 (Isoform X‐Su(H)2) Xenopus laevis (African clawed frog) 481 92.00% Suppressor of hairless protein homolog (X‐ XSu(H)1 ARP31121_P050 SUH_XENLA Su(H)) Xenopus laevis (African clawed frog) 501 92.00% Xenopus tropicalis (Western clawed frog) ARP47372_P050 B1H0Z0_XENTR LOC100145280 protein (Silurana tropicalis) 301 78.00% ARP47372_P050 A9JS93_XENLA LOC100127342 protein (Fragment) Xenopus laevis (African clawed frog) 298 78.00% RNF6 ARP32151_P050 Q7T036_XENLA XRnf12C Xenopus laevis (African clawed frog) 825 100.00% Xenopus tropicalis (Western clawed frog) RNF6 ARP32151_P050 B7ZUL1_XENTR Ring finger protein, LIM domain interacting (Silurana tropicalis) 639 100.00% RNF6 ARP32151_P050 B7ZR09_XENLA XRnf12C protein Xenopus laevis (African clawed frog) 751 100.00% RNF6 ARP32151_P050 RF12A_XENLA Isoform 2 Xenopus laevis (African clawed frog) 616 100.00% E3 ubiquitin‐protein RNF12 (EC 6.3.2.‐) Xenopus tropicalis (Western clawed frog) RNF6 ARP32151_P050 RNF12_XENTR (RING finger protein 12) (Silurana tropicalis) 639 100.00%

E3 ubiquitin‐protein ligase RNF12‐B (EC 6.3.2.‐ RNF6 ARP32151_P050 RF12B_XENLA ) (RING finger protein 12‐B) (XRnf12B) Xenopus laevis (African clawed frog) 757 100.00%

E3 ubiquitin‐protein ligase RNF12‐A (EC 6.3.2.‐ RNF6 ARP32151_P050 RF12A_XENLA ) (RING finger protein 12‐A) (XRnf12) Xenopus laevis (African clawed frog) 622 100.00%

ORF Names:v1g86891OrganismNematostell a vectensis (Starlet sea anemone) ARP32390_P050 Q68F47_XENLA MGC81733 protein Xenopus laevis (African clawed frog) 309 85.00%

ORF Names:v1g86891OrganismNematostell a vectensis (Starlet sea anemone) ARP32390_P050 Q5HZN8_XENLA LOC496346 protein Xenopus laevis (African clawed frog) 309 85.00% LOC100037026 ARP31531_P050 A9JS29_XENLA Putative uncharacterized protein Xenopus laevis (African clawed frog) 257 100.00% LOC100037026 ARP31531_P050 A2VDE3_XENLA LOC100037233 protein (Fragment) Xenopus laevis (African clawed frog) 255 100.00% LOC100037026 ARP31531_P050 A1L3J8_XENLA LOC100037026 protein Xenopus laevis (African clawed frog) 258 100.00% Vacuolar‐sorting protein SNF8 (ESCRT‐II Xenopus tropicalis (Western clawed frog) LOC100037026 ARP31531_P050 SNF8_XENTR complex subunit VPS22) (Silurana tropicalis) 257 100.00% Xenopus tropicalis (Western clawed frog) ARP33413_P050 A4IIL9_XENTR Tcf4 protein (Fragment) (Silurana tropicalis) 345 85.00% laptm4b ARP47442_P050 B1H1Y1_XENLA LOC100158325 protein Xenopus laevis (African clawed frog) 225 78.00% Xenopus tropicalis (Western clawed frog) ARP47666_P050 B6ICZ8_XENTR Putative uncharacterized protein (Silurana tropicalis) 528 78.00% ARP47666_P050 Q6IR95_XENLA MGC80043 protein Xenopus laevis (African clawed frog) 513 78.00% Xenopus tropicalis (Western clawed frog) Fam70a ARP47380_P050 Q5HZT3_XENTR Hypothetical LOC497005 (Silurana tropicalis) 235 83.00% Fam70a ARP47380_P050 FA70A_XENLA Protein FAM70A Xenopus laevis (African clawed frog) 321 83.00% Xenopus tropicalis (Western clawed frog) etv7 P100807_P050 Q28DU7_XENTR Ets variant 6 (TEL oncogene) (Silurana tropicalis) 450 100.00% Xenopus tropicalis (Western clawed frog) etv7 P100807_P050 Q0IHQ4_XENTR Ets variant 6 (Silurana tropicalis) 450 100.00% etv7 P100807_P050 B3VKU4_XENLA Ets variant 6 Xenopus laevis (African clawed frog) 448 100.00% Activity‐dependent neuroprotector Xenopus tropicalis (Western clawed frog) Adnp ARP39186_P050 Q28CN1_XENTR (Fragment) (Silurana tropicalis) 864 92.00%

ORF Names:CH211‐145O7.4‐001 EMBL CAM12896.1OrganismDanio rerio Xenopus tropicalis (Western clawed frog) () (Brachydanio rerio) ARP31377_P050 A4IGZ5_XENTR LOC100038288 protein (Fragment) (Silurana tropicalis) 306 84.00%

ORF Names:CH211‐145O7.4‐001 EMBL CAM12896.1OrganismDanio rerio (Zebrafish) (Brachydanio rerio) ARP31377_P050 Q91639_XENLA Fos‐related antigen‐2 Xenopus laevis (African clawed frog) 319 84.00%

ORF Names:CH211‐145O7.4‐001 EMBL CAM12896.1OrganismDanio rerio (Zebrafish) (Brachydanio rerio) ARP31377_P050 B7ZR03_XENLA Fos‐related antigen‐2 Xenopus laevis (African clawed frog) 319 84.00%

ORF Names:CH211‐145O7.4‐001 EMBL CAM12896.1OrganismDanio rerio V‐fos FBJ murine osteosarcoma viral Xenopus tropicalis (Western clawed frog) (Zebrafish) (Brachydanio rerio) ARP31377_P050 Q28CJ5_XENTR oncogene homolog (Silurana tropicalis) 368 76.00% ARP31277_P050 Q91639_XENLA Fos‐related antigen‐2 Xenopus laevis (African clawed frog) 319 81.00% fosl2 ARP31277_P050 B7ZR03_XENLA Fos‐related antigen‐2 Xenopus laevis (African clawed frog) 319 81.00% Heat shock cognate 70.II (Heat shock cognate Hspa1l ARP48445_P050 Q91993_XENLA 70.II protein) Xenopus laevis (African clawed frog) 647 100.00% Hspa1l ARP48445_P050 Q8AVE2_XENLA Hsc70 protein Xenopus laevis (African clawed frog) 650 100.00% Hspa1l ARP48445_P050 Q7ZTK6_XENLA MGC53952 protein Xenopus laevis (African clawed frog) 646 100.00% Hspa1l ARP48445_P050 Q6DCD3_XENLA protein Xenopus laevis (African clawed frog) 647 100.00% Hspa1l ARP48445_P050 Q6AZH8_XENLA Putative uncharacterized protein Xenopus laevis (African clawed frog) 652 100.00% Xenopus tropicalis (Western clawed frog) Hspa1l ARP48445_P050 Q0V9A5_XENTR Heat shock 70kDa protein 1‐like (Silurana tropicalis) 639 100.00% Xenopus tropicalis (Western clawed frog) Hspa1l ARP48445_P050 A9JTJ5_XENTR Hsp70 protein (Silurana tropicalis) 643 100.00% Xenopus tropicalis (Western clawed frog) Hspa1l ARP48445_P050 A4IGS8_XENTR Hsp70 protein (Fragment) (Silurana tropicalis) 507 100.00% Hspa1l ARP48445_P050 A1L3K5_XENLA LOC100037033 protein Xenopus laevis (African clawed frog) 646 100.00% Xenopus tropicalis (Western clawed frog) GATA3 ARP32548_P050 Q6DIQ6_XENTR GATA binding protein 3 (Silurana tropicalis) 437 78.00% GATA3 ARP32548_P050 Q2TAR8_XENLA XGATA‐3 protein Xenopus laevis (African clawed frog) 435 78.00% GATA‐binding factor 3 (Transcription factor GATA3 ARP32548_P050 GATA3_XENLA xGATA‐3) Xenopus laevis (African clawed frog) 435 78.00% Xenopus tropicalis (Western clawed frog) GSM1 ARP47383_P050 SOX9_XENTR Transcription factor Sox‐9 (Xt‐) (Silurana tropicalis) 482 84.00% ORF Names:GSPATT00007737001 EMBL CAK70602.1OrganismParamecium tetraurelia P100987_P050 Q71N44_XENLA Transcription factor IIA large subunit Xenopus laevis (African clawed frog) 370 85.00% ORF Names:GSPATT00007737001 EMBL CAK70602.1OrganismParamecium TFIIAa/b‐2 protein (Transcription factor IIA tetraurelia P100987_P050 Q6XPY4_XENLA large subunit‐2) Xenopus laevis (African clawed frog) 367 85.00% ORF Names:GSPATT00007737001 EMBL CAK70602.1OrganismParamecium tetraurelia P100987_P050 Q6XPY2_XENLA Transcription factor IIA large subunit‐1 Xenopus laevis (African clawed frog) 370 85.00% ORF Names:GSPATT00007737001 EMBL CAK70602.1OrganismParamecium tetraurelia P100987_P050 Q6ING6_XENLA TFIIAa/b‐2 protein (Fragment) Xenopus laevis (African clawed frog) 366 85.00% ORF Names:GSPATT00007737001 EMBL CAK70602.1OrganismParamecium tetraurelia P100987_P050 Q5HZB8_XENLA Putative uncharacterized protein Xenopus laevis (African clawed frog) 369 85.00% ORF Names:GSPATT00007737001 EMBL CAK70602.1OrganismParamecium Xenopus tropicalis (Western clawed frog) tetraurelia P100987_P050 Q28E35_XENTR General transcription factor IIA, 1 (Silurana tropicalis) 367 85.00% ORF Names:GSPATT00007737001 EMBL CAK70602.1OrganismParamecium tetraurelia P100987_P050 B7ZS19_XENLA Putative uncharacterized protein Xenopus laevis (African clawed frog) 367 85.00% ORF Names:GSPATT00007737001 EMBL CAK70602.1OrganismParamecium High mobility group B3b protein (LOC734200 tetraurelia P100987_P050 Q1XCD9_XENLA protein) Xenopus laevis (African clawed frog) 201 90.00% ORF Names:GSPATT00007737001 EMBL CAK70602.1OrganismParamecium Xenopus tropicalis (Western clawed frog) tetraurelia P100987_P050 Q6NVT6_XENTR Calreticulin (Silurana tropicalis) 416 84.00% ORF Names:GSPATT00007737001 EMBL CAK70602.1OrganismParamecium tetraurelia P100987_P050 Q5BJ40_XENLA MGC98482 protein Xenopus laevis (African clawed frog) 946 81.00% ORF Names:GSPATT00007737001 EMBL CAK70602.1OrganismParamecium tetraurelia P100987_P050 Q91596_XENLA High mobility group protein‐1 Xenopus laevis (African clawed frog) 210 84.00% ORF Names:GSPATT00007737001 EMBL CAK70602.1OrganismParamecium tetraurelia P100987_P050 Q91710_XENLA Calreticulin (Fragment) Xenopus laevis (African clawed frog) 411 76.00% ORF Names:GSPATT00007737001 EMBL CAK70602.1OrganismParamecium tetraurelia P100987_P050 Q7ZXY3_XENLA Crc protein Xenopus laevis (African clawed frog) 418 76.00% ORF Names:TVAG_093750 EMBL EAY22201.1OrganismTrichomonas vaginalis ARP32618_P050 Q66J55_XENLA Hdac2 protein Xenopus laevis (African clawed frog) 488 85.00% ORF Names:TVAG_093750 EMBL EAY22201.1OrganismTrichomonas Xenopus tropicalis (Western clawed frog) vaginalis ARP32618_P050 Q28CG8_XENTR deacetylase 2 (Silurana tropicalis) 488 85.00% ORF Names:TVAG_093750 EMBL EAY22201.1OrganismTrichomonas Xenopus tropicalis (Western clawed frog) vaginalis ARP32618_P050 Q6GLI1_XENTR 2 (Silurana tropicalis) 488 78.00% IRF8 P100841_P050 Q6DE53_XENLA Icsbp1‐prov protein Xenopus laevis (African clawed frog) 411 100.00% CDC45L ARP51333_P050 Q6AZM5_XENLA Cdc45l‐prov protein Xenopus laevis (African clawed frog) 567 78.00% Xenopus tropicalis (Western clawed frog) CDC45L ARP51333_P050 Q0IIT2_XENTR LOC779545 protein (Fragment) (Silurana tropicalis) 548 78.00% CDC45L ARP51333_P050 CDC45_XENLA Cell division control protein 45 homolog Xenopus laevis (African clawed frog) 567 78.00% Putative uncharacterized protein TMEM144 ARP47426_P050 B7ZSD7_XENLA LOC100126624 Xenopus laevis (African clawed frog) 356 85.00% Xenopus tropicalis (Western clawed frog) TMEM144 ARP47426_P050 B1WB31_XENTR LOC100135165 protein (Silurana tropicalis) 359 85.00% Xenopus tropicalis (Western clawed frog) TMEM144 ARP47426_P050 A9UL83_XENTR LOC100135165 protein (Silurana tropicalis) 312 85.00% TMEM144 ARP47426_P050 A8E5Y8_XENLA LOC100126624 protein Xenopus laevis (African clawed frog) 356 85.00% Ordered Names:Ping_2780OrganismPsychromo Mitochondrial dihydrolipoamide nas ingrahamii (strain 37) ARP41995_P050 Q8JHX7_XENLA acetyltransferase Xenopus laevis (African clawed frog) 628 92.00% Ordered Locus Names:Ping_2780OrganismPsychromo nas ingrahamii (strain 37) ARP41995_P050 Q4KLR0_XENLA LOC398314 protein (Fragment) Xenopus laevis (African clawed frog) 590 92.00% Ordered Locus Names:Ping_2780OrganismPsychromo nas ingrahamii (strain 37) ARP41995_P050 Q32NX8_XENLA LOC398314 protein (Fragment) Xenopus laevis (African clawed frog) 623 92.00% Ordered Locus Names:Ping_2780OrganismPsychromo Xenopus tropicalis (Western clawed frog) nas ingrahamii (strain 37) ARP41995_P050 B1H2L3_XENTR Putative uncharacterized protein (Silurana tropicalis) 628 92.00% Ordered Locus Names:Ping_2780OrganismPsychromo nas ingrahamii (strain 37) ARP41995_P050 A0AUS4_XENLA LOC398314 protein Xenopus laevis (African clawed frog) 628 92.00% TCF7L2 ARP33414_P050 Q9IAC9_XENLA T‐cell factor 4 Xenopus laevis (African clawed frog) 477 92.00% TCF7L2 ARP33414_P050 Q90ZB4_XENLA T‐cell factor XTCF‐4C Xenopus laevis (African clawed frog) 473 92.00% TCF7L2 ARP33414_P050 Q90ZB5_XENLA T‐cell factor XTCF‐4A Xenopus laevis (African clawed frog) 482 84.00% TCF7L2 ARP33414_P050 E1AZB0_XENLA Transcription factor 7‐like 2 (Fragment) Xenopus laevis (African clawed frog) 304 84.00% Xenopus tropicalis (Western clawed frog) TCF7L2 ARP33414_P050 A4IIL9_XENTR Tcf4 protein (Fragment) (Silurana tropicalis) 345 84.00% Xenopus tropicalis (Western clawed frog) Myod1 ARP32134_P050 Q8QG50_XENTR Myogenic factor 5 (Myogenic factor MYF‐5) (Silurana tropicalis) 255 92.00% Xenopus tropicalis (Western clawed frog) Myod1 ARP32134_P050 Q7T108_XENTR Myf5 protein (Silurana tropicalis) 220 92.00% Myod1 ARP32134_P050 B7ZRD6_XENLA Myogenic factor Xmyf‐5 Xenopus laevis (African clawed frog) 255 85.00% Myod1 ARP32134_P050 MYF5_XENLA Myogenic factor 5 (Myf‐5) Xenopus laevis (African clawed frog) 255 85.00% homolog protein (Myogenin‐like Myod1 ARP32134_P050 Q92001_XENLA protein protein) (Fragment) Xenopus laevis (African clawed frog) 167 78.00% Myogenin U2 (Myogenin‐related U2, Myod1 ARP32134_P050 Q8UUX7_XENLA myogenic transcription factor) Xenopus laevis (African clawed frog) 236 78.00% X.laevis MyoD1 homologue (mf11) gene Myod1 ARP32134_P050 Q91791_XENLA (expressed prior to somite formation) Xenopus laevis (African clawed frog) 190 78.00% Myod1 ARP32134_P050 Q8AVZ0_XENLA Myod1‐a protein Xenopus laevis (African clawed frog) 289 78.00% MyoD protein (Myogenic differentiation 1) Xenopus tropicalis (Western clawed frog) Myod1 ARP32134_P050 Q7T109_XENTR (Myogenic factor 3) (Silurana tropicalis) 288 78.00% Myoblast determination protein 1 homolog A Myod1 ARP32134_P050 MYODA_XENLA (Myogenic factor 1) Xenopus laevis (African clawed frog) 289 78.00% Myod1 ARP32134_P050 Q8AWF3_XENLA Muscle regulatory factor 4b (Fragment) Xenopus laevis (African clawed frog) 171 78.00% Myod1 ARP32134_P050 Q5U4S0_XENLA LOC495450 protein (MRF4b) Xenopus laevis (African clawed frog) 241 78.00% Myod1 ARP32134_P050 B7ZQB0_XENLA MRF4a Xenopus laevis (African clawed frog) 240 78.00% Xenopus tropicalis (Western clawed frog) Myod1 ARP32134_P050 A8E5S2_XENTR Myogenic factor 6 (Herculin) (Silurana tropicalis) 241 78.00% Myod1 ARP32134_P050 A7UCI1_XENLA MRF4a (Muscle regulatory factor 4a) Xenopus laevis (African clawed frog) 240 78.00% Myogenic factor 6 (Myf‐6) (Muscle‐specific Myod1 ARP32134_P050 MYF6_XENLA regulatory factor 4) Xenopus laevis (African clawed frog) 240 78.00% Xenopus tropicalis (Western clawed frog) ARP46963_P050 Q0P4N7_XENTR Astrotactin (Silurana tropicalis) 1302 78.00% arf‐1 ARP48184_P050 Q8AVF6_XENLA ADP ribosylation factor 1 (Arf2‐prov protein) Xenopus laevis (African clawed frog) 181 100.00% Xenopus tropicalis (Western clawed frog) arf‐1 ARP48184_P050 Q6P7Z6_XENTR Putative uncharacterized protein MGC76046 (Silurana tropicalis) 181 100.00% ADP‐ribosylation factor 1 (ADP‐ribosylation Xenopus tropicalis (Western clawed frog) arf‐1 ARP48184_P050 Q6NT85_XENTR factor 3) (Silurana tropicalis) 181 100.00% arf‐1 ARP48184_P050 Q6DE26_XENLA MGC80261 protein Xenopus laevis (African clawed frog) 181 100.00% Xenopus tropicalis (Western clawed frog) arf‐1 ARP48184_P050 B0JZE7_XENTR LOC100145191 protein (Silurana tropicalis) 181 100.00% arf‐1 ARP48184_P050 A1L3K6_XENLA Arf‐1 protein Xenopus laevis (African clawed frog) 181 100.00% arf‐1 ARP48184_P050 ARF1_XENLA ADP‐ribosylation factor 1 Xenopus laevis (African clawed frog) 181 100.00% Xenopus tropicalis (Western clawed frog) ABI3BP ARP47157_P050 Q504M1_XENTR Tarsh protein (Silurana tropicalis) 1516 75.00% Xenopus tropicalis (Western clawed frog) LOC100124912 ARP47420_P050 A4IHX5_XENTR LOC100124912 protein (Fragment) (Silurana tropicalis) 200 85.00% Cyp28d2 ARP43670_P050 Q7SYY2_XENLA MGC64404 protein Xenopus laevis (African clawed frog) 503 83.00% Xenopus tropicalis (Western clawed frog) Cyp28d2 ARP43670_P050 Q501K6_XENTR Putative uncharacterized protein mgc108213 (Silurana tropicalis) 504 83.00% Xenopus tropicalis (Western clawed frog) Cyp28d2 ARP43670_P050 Q4VA77_XENTR Putative uncharacterized protein mgc108077 (Silurana tropicalis) 507 100.00% Cyp28d2 ARP43670_P050 A8E616_XENLA LOC100126648 protein Xenopus laevis (African clawed frog) 504 100.00% ORF Names:PANDA_014123 EMBL Retinal homeobox protein Rx‐B ( and EFB15300.1OrganismAiluropoda anterior neural fold homeobox protein B) melanoleuca (Giant panda) ARP31926_P050 RXB_XENLA (Rx2A) (Xrx2) Xenopus laevis (African clawed frog) 325 78.00% ORF Names:PANDA_014123 EMBL Retinal homeobox protein Rx‐A (Rx1A) (Xrx1) EFB15300.1OrganismAiluropoda (Retina and anterior neural fold homeobox melanoleuca (Giant panda) ARP31926_P050 RXA_XENLA protein A) Xenopus laevis (African clawed frog) 322 78.00% LOC100036954 ARP43601_P050 Q58EW6_XENLA MGC97885 protein Xenopus laevis (African clawed frog) 495 92.00% Xenopus tropicalis (Western clawed frog) LOC100036954 ARP43601_P050 B0K002_XENTR LOC100145270 protein (Silurana tropicalis) 506 92.00% LOC100036954 ARP43601_P050 A1L2U3_XENLA LOC100036954 protein Xenopus laevis (African clawed frog) 526 92.00% LOC100036954 ARP43601_P050 OPTN_XENLA Optineurin Xenopus laevis (African clawed frog) 532 92.00% skiip ARP32294_P050 Q4V7V5_XENLA Putative uncharacterized protein (Fragment) Xenopus laevis (African clawed frog) 323 85.00% skiip ARP32294_P050 Q2VPI1_XENLA MGC132028 protein Xenopus laevis (African clawed frog) 535 85.00% Xenopus tropicalis (Western clawed frog) skiip ARP32294_P050 Q28H99_XENTR SKI interacting protein (Silurana tropicalis) 535 78.00% Xenopus tropicalis (Western clawed frog) skiip ARP32294_P050 B1H2X1_XENTR SKI interacting protein (Silurana tropicalis) 535 78.00% Beta‐galactosamide alpha‐2,6‐ Xenopus tropicalis (Western clawed frog) St6galnac2 ARP47446_P050 Q704X5_XENTR sialyltransferase (Silurana tropicalis) 388 78.00% Beta‐galactosamide alpha‐2,6‐ Xenopus tropicalis (Western clawed frog) St6galnac2 ARP47446_P050 A4IIC7_XENTR sialyltransferase (Silurana tropicalis) 388 78.00% Xenopus tropicalis (Western clawed frog) ARP31477_P050 B4F723_XENTR Putative uncharacterized protein (Silurana tropicalis) 360 92.00% Zinc transporter 9 (ZnT‐9) (Solute carrier ARP31477_P050 ZNT9_XENLA 30 member 9) Xenopus laevis (African clawed frog) 559 92.00% Hnf1b ARP32320_P050 Q7T0V4_XENLA Tcf2 protein Xenopus laevis (African clawed frog) 561 92.00% Hnf1b ARP32320_P050 Q6PAX5_XENLA MGC68543 protein Xenopus laevis (African clawed frog) 561 92.00% Hepatocyte nuclear factor 1‐beta (HNF‐1B) Hnf1b ARP32320_P050 HNF1B_XENLA (LFB3) (XlFB3) Xenopus laevis (African clawed frog) 561 92.00% ORF Names:ACLA_068740 EMBL EAW13846.1OrganismAspergillus clavatus ARP43517_T100 Q7SZS3_XENLA Got2 protein Xenopus laevis (African clawed frog) 427 92.00% Aspartate aminotransferase, mitochondrial ORF Names:ACLA_068740 EMBL (mAspAT) (EC 2.6.1.1) (Glutamate EAW13846.1OrganismAspergillus oxaloacetate transaminase 2) (Transaminase Xenopus tropicalis (Western clawed frog) clavatus ARP43517_T100 AATM_XENTR A) (Silurana tropicalis) 427 92.00% MGC155219 ARP48452_P050 Q6GMB8_XENLA MGC81894 protein Xenopus laevis (African clawed frog) 396 85.00% Xenopus tropicalis (Western clawed frog) MGC155219 ARP48452_P050 Q6DFP8_XENTR MGC79696 protein (Novel protein) (Silurana tropicalis) 398 78.00% MGC155219 ARP48452_P050 Q3KQ46_XENLA MGC130975 protein Xenopus laevis (African clawed frog) 397 78.00% Xenopus tropicalis (Western clawed frog) ARP47391_P050 Q0P4S7_XENTR Neuropilin‐and tolloid‐like protein 2 (Silurana tropicalis) 525 85.00% ORF Names:EAG_07151 EMBL EFN68551.1OrganismCamponotus floridanus ARP47645_P050 B7ZRB9_XENLA Putative uncharacterized protein Xenopus laevis (African clawed frog) 361 100.00% ORF Names:EAG_07151 EMBL EFN68551.1OrganismCamponotus floridanus ARP47645_P050 Q9DFC4_XENLA Bar homeobox protein XBH1 Xenopus laevis (African clawed frog) 365 92.00% ORF Names:EAG_07151 EMBL EFN68551.1OrganismCamponotus floridanus ARP47645_P050 Q9DFC3_XENLA Bar homeobox protein XBH2 (Fragment) Xenopus laevis (African clawed frog) 322 92.00% PHB ARP32807_P050 Q7ZYF7_XENLA MGC53103 protein Xenopus laevis (African clawed frog) 272 85.00% PHB ARP32807_P050 Q7SY83_XENLA MGC64447 protein Xenopus laevis (African clawed frog) 272 85.00% Xenopus tropicalis (Western clawed frog) PHB ARP32807_P050 Q6P850_XENTR Prohibitin (Silurana tropicalis) 272 85.00% PHB ARP32807_P050 Q05BI7_XENLA MGC64447 protein Xenopus laevis (African clawed frog) 255 85.00% Xenopus tropicalis (Western clawed frog) PHB ARP32807_P050 B0JZX1_XENTR Phb protein (Silurana tropicalis) 272 85.00% Xenopus tropicalis (Western clawed frog) ARP47562_P050 A8E4V1_XENTR Pou6f1 protein (Silurana tropicalis) 478 100.00% Xenopus tropicalis (Western clawed frog) ARP44850_P050 A4II02_XENTR Sil1 protein (Silurana tropicalis) 453 84.00% Xenopus tropicalis (Western clawed frog) Neto2 ARP47390_P050 Q0P4S7_XENTR Neuropilin‐and tolloid‐like protein 2 (Silurana tropicalis) 525 85.00% ORF Names:ACLA_092280 EMBL EAW11530.1OrganismAspergillus GA binding protein transcription factor, beta Xenopus tropicalis (Western clawed frog) clavatus P100833_P050 Q68FB9_XENTR subunit 1 (Silurana tropicalis) 404 100.00% ORF Names:ACLA_092280 EMBL EAW11530.1OrganismAspergillus GA binding protein transcription factor, beta Xenopus tropicalis (Western clawed frog) clavatus P100833_P050 Q28BY9_XENTR subunit 2 (Silurana tropicalis) 385 100.00% ORF Names:ACLA_092280 EMBL EAW11530.1OrganismAspergillus clavatus P100833_P050 Q91923_XENLA XrpFIbeta1 Xenopus laevis (African clawed frog) 385 92.00% ORF Names:ACLA_092280 EMBL EAW11530.1OrganismAspergillus clavatus P100833_P050 Q91922_XENLA XrpFIbeta1 (Fragment) Xenopus laevis (African clawed frog) 301 92.00% ORF Names:ACLA_092280 EMBL EAW11530.1OrganismAspergillus clavatus P100833_P050 Q7ZWX6_XENLA Gabpb1‐prov protein Xenopus laevis (African clawed frog) 385 92.00% ORF Names:ACLA_092280 EMBL EAW11530.1OrganismAspergillus clavatus P100833_P050 B7ZQV8_XENLA XrpFIbeta1 Xenopus laevis (African clawed frog) 385 92.00% ORF Names:ACLA_092280 EMBL EAW11530.1OrganismAspergillus Novel protein similar to GA binding protein Xenopus tropicalis (Western clawed frog) clavatus P100833_P050 Q28C56_XENTR transcription factor, beta subunit 2 (Silurana tropicalis) 383 92.00% ORF Names:ACLA_092280 EMBL EAW11530.1OrganismAspergillus Xenopus tropicalis (Western clawed frog) clavatus P100833_P050 B1H0Z2_XENTR Putative uncharacterized protein (Silurana tropicalis) 425 92.00% ORF Names:ACLA_092280 EMBL EAW11530.1OrganismAspergillus clavatus P100833_P050 Q6DFK5_XENLA Ankhd1‐prov protein Xenopus laevis (African clawed frog) 380 84.00% HOXA7 ARP32637_P050 B7ZRU4_XENLA Homeobox protein Xenopus laevis (African clawed frog) 209 92.00% Homeobox protein Hox‐A7 (Xhox‐36) (XlHbox‐ HOXA7 ARP32637_P050 HXA7_XENLA 3) Xenopus laevis (African clawed frog) 209 92.00% Xenopus tropicalis (Western clawed frog) LRRN3 ARP47422_P050 Q0D2D1_XENTR Leucine rich repeat neuronal 3 (Silurana tropicalis) 706 78.00% GA binding protein transcription factor, beta Xenopus tropicalis (Western clawed frog) P100925_P050 Q68FB9_XENTR subunit 1 (Silurana tropicalis) 404 92.00% GA binding protein transcription factor, beta Xenopus tropicalis (Western clawed frog) P100925_P050 Q28BY9_XENTR subunit 2 (Silurana tropicalis) 385 92.00% P100925_P050 Q91923_XENLA XrpFIbeta1 Xenopus laevis (African clawed frog) 385 92.00% P100925_P050 Q91922_XENLA XrpFIbeta1 (Fragment) Xenopus laevis (African clawed frog) 301 92.00% P100925_P050 Q7ZWX6_XENLA Gabpb1‐prov protein Xenopus laevis (African clawed frog) 385 92.00% P100925_P050 B7ZQV8_XENLA XrpFIbeta1 Xenopus laevis (African clawed frog) 385 92.00% ARP48627_P050 Q7ZTJ0_XENLA MGC53207 protein Xenopus laevis (African clawed frog) 382 85.00% nnt ARP46892_P050 Q66J07_XENLA MGC83563 protein Xenopus laevis (African clawed frog) 1086 100.00% Xenopus tropicalis (Western clawed frog) nnt ARP46892_P050 B2GUE7_XENTR LOC100158572 protein (Silurana tropicalis) 1086 100.00% Xenopus tropicalis (Western clawed frog) nnt ARP46892_P050 B3DLP8_XENTR LOC100170519 protein (Fragment) (Silurana tropicalis) 452 92.00% ARP47068_P050 Q0VGX4_XENLA MGC82036 protein Xenopus laevis (African clawed frog) 465 100.00% Xenopus tropicalis (Western clawed frog) ARP47068_P050 B1H3H9_XENTR LOC100145636 protein (Silurana tropicalis) 465 100.00% ARP31539_P050 OSR2B_XENLA Protein odd‐skipped‐related 2‐B Xenopus laevis (African clawed frog) 271 92.00% ARP31539_P050 OSR2A_XENLA Protein odd‐skipped‐related 2‐A (XOsr2) Xenopus laevis (African clawed frog) 271 92.00% Xenopus tropicalis (Western clawed frog) hoxd4b ARP39383_P050 Q5M797_XENTR Homeobox A5 (Silurana tropicalis) 274 100.00% Xenopus tropicalis (Western clawed frog) hoxd4b ARP39383_P050 A4QNI0_XENTR Hoxb5 protein (Silurana tropicalis) 258 100.00% Homeobox protein Hox‐B5 (Xhox‐1B) (XlHbox‐ hoxd4b ARP39383_P050 HXB5_XENLA 4) (Fragment) Xenopus laevis (African clawed frog) 230 100.00% hoxd4b ARP39383_P050 Q6TGB6_XENLA HOXD4 (Fragment) Xenopus laevis (African clawed frog) 218 92.00% Xenopus tropicalis (Western clawed frog) hoxd4b ARP39383_P050 Q5EB31_XENTR Hoxb4 protein (Fragment) (Silurana tropicalis) 233 92.00% hoxd4b ARP39383_P050 Q2TAR0_XENLA Putative uncharacterized protein Xenopus laevis (African clawed frog) 237 92.00% PIAS4 ARP33011_P050 Q71QG2_XENLA PIAS Xenopus laevis (African clawed frog) 499 100.00% PIAS4 ARP33011_P050 Q640I7_XENLA LOC494663 protein Xenopus laevis (African clawed frog) 501 100.00% Xenopus tropicalis (Western clawed frog) PIAS4 ARP33011_P050 Q5I099_XENTR Protein inhibitor of activated STAT, 4 (Silurana tropicalis) 501 100.00% SIX1 ARP32383_P050 Q9W7H7_XENLA Homeobox protein SIX6.1 (Fragment) Xenopus laevis (African clawed frog) 153 85.00% SIX1 ARP32383_P050 Q9PWD9_XENLA Homeobox protein Optx2 Xenopus laevis (African clawed frog) 244 85.00% Xenopus tropicalis (Western clawed frog) SIX1 ARP32383_P050 A4II51_XENTR Six6 protein (Silurana tropicalis) 244 85.00% Homeobox transcription factor Six3 (Six3 SIX1 ARP32383_P050 Q9IAK3_XENLA protein) Xenopus laevis (African clawed frog) 291 78.00% SIX1 ARP32383_P050 Q9DDV3_XENLA Homeobox protein Six3.2 (Fragment) Xenopus laevis (African clawed frog) 164 78.00% SIX1 ARP32383_P050 Q9DDV2_XENLA Homeobox protein Six6.2 (Fragment) Xenopus laevis (African clawed frog) 164 78.00% SIX1 ARP32383_P050 Q8AVH6_XENLA Six6‐A protein Xenopus laevis (African clawed frog) 244 78.00% SIX1 ARP32383_P050 Q9W7H9_XENLA Homeobox protein SIX1 (Fragment) Xenopus laevis (African clawed frog) 165 78.00% SIX1 ARP32383_P050 Q9W7H8_XENLA Homeobox protein SIX2 (Fragment) Xenopus laevis (African clawed frog) 168 78.00% SIX1 ARP32383_P050 Q9I8H0_XENLA Homeobox protein SIX1 Xenopus laevis (African clawed frog) 284 78.00% SIX1 ARP32383_P050 Q2TAS7_XENLA MGC130961 protein Xenopus laevis (African clawed frog) 276 78.00% Xenopus tropicalis (Western clawed frog) SIX1 ARP32383_P050 A4IHN6_XENTR Six1 protein (Silurana tropicalis) 284 78.00% Xenopus tropicalis (Western clawed frog) SIX1 ARP32383_P050 A4IHH9_XENTR Six2 protein (Silurana tropicalis) 289 78.00% Lin7c ARP42907_P050 Q7ZYU3_XENLA Lin7c‐prov protein Xenopus laevis (African clawed frog) 197 85.00% Lin7c ARP42907_P050 Q9W7H9_XENLA Homeobox protein SIX1 (Fragment) Xenopus laevis (African clawed frog) 165 78.00% Lin7c ARP42907_P050 Q9W7H8_XENLA Homeobox protein SIX2 (Fragment) Xenopus laevis (African clawed frog) 168 78.00% Lin7c ARP42907_P050 Q9I8H0_XENLA Homeobox protein SIX1 Xenopus laevis (African clawed frog) 284 78.00% Lin7c ARP42907_P050 Q2TAS7_XENLA MGC130961 protein Xenopus laevis (African clawed frog) 276 78.00% Xenopus tropicalis (Western clawed frog) Lin7c ARP42907_P050 A4IHN6_XENTR Six1 protein (Silurana tropicalis) 284 78.00% Xenopus tropicalis (Western clawed frog) Lin7c ARP42907_P050 A4IHH9_XENTR Six2 protein (Silurana tropicalis) 289 78.00% lin‐7 ARP42908_P050 Q7ZYU3_XENLA Lin7c‐prov protein Xenopus laevis (African clawed frog) 197 100.00% Xenopus tropicalis (Western clawed frog) fam19a5 ARP44484_P050 A4II81_XENTR LOC100124962 protein (Silurana tropicalis) 125 90.00% cbx4 ARP30002_P050 Q91647_XENLA XPolycomb Xenopus laevis (African clawed frog) 521 85.00% cbx4 ARP30002_P050 Q6GQI4_XENLA Putative uncharacterized protein (Fragment) Xenopus laevis (African clawed frog) 262 85.00% cbx4 ARP30002_P050 B7ZRU1_XENLA Chromobox homolog 4 (Polycomb) Xenopus laevis (African clawed frog) 521 85.00% Xenopus tropicalis (Western clawed frog) lrrc24 ARP44738_P050 Q0V9V1_XENTR Leucine rich repeat containing 24 (Silurana tropicalis) 540 85.00% nptn ARP46898_P050 Q7ZXR4_XENLA LOC398501 protein (Fragment) Xenopus laevis (African clawed frog) 303 85.00% nptn ARP46898_P050 Q6INF0_XENLA LOC398501 protein (Fragment) Xenopus laevis (African clawed frog) 321 85.00% nptn ARP46898_P050 Q4V828_XENLA Putative uncharacterized protein (Fragment) Xenopus laevis (African clawed frog) 320 85.00% nptn ARP46898_P050 Q32NA7_XENLA LOC398501 protein (Fragment) Xenopus laevis (African clawed frog) 321 85.00% Xenopus tropicalis (Western clawed frog) nptn ARP46898_P050 Q28HZ9_XENTR Stromal cell derived factor 1 (Silurana tropicalis) 291 85.00% Xenopus tropicalis (Western clawed frog) nptn ARP46898_P050 Q0V9X4_XENTR LOC733721 protein (Fragment) (Silurana tropicalis) 436 85.00% nptn ARP46898_P050 A0JMY2_XENLA LOC398501 protein Xenopus laevis (African clawed frog) 290 85.00% nptn ARP46898_P050 Q5HZR6_XENLA LOC496324 protein Xenopus laevis (African clawed frog) 292 84.00% Xenopus tropicalis (Western clawed frog) PCDHB7 ARP45334_P050 Q0IHR9_XENTR Pcdha13 protein (Fragment) (Silurana tropicalis) 911 84.00% Xenopus tropicalis (Western clawed frog) PCDHB7 ARP45334_P050 B0Z663_XENTR Protocadherin delta 1 (Silurana tropicalis) 958 84.00% Xenopus tropicalis (Western clawed frog) ift140 ARP36619_P050 A9JTK8_XENTR Ift140 protein (Silurana tropicalis) 1461 76.00% ORF Names:GSPATT00007366001 EMBL CAK69926.1OrganismParamecium tetraurelia ARP32462_P050 Q4KL83_XENLA LOC733313 protein (Fragment) Xenopus laevis (African clawed frog) 200 92.00% ORF Names:GSPATT00007366001 EMBL CAK69926.1OrganismParamecium of RNA polymerase II transcription Xenopus tropicalis (Western clawed frog) tetraurelia ARP32462_P050 MED1_XENTR subunit 1 (Mediator complex subunit 1) (Silurana tropicalis) 1573 92.00% ORF Names:GSPATT00007366001 EMBL CAK69926.1OrganismParamecium Mediator of RNA polymerase II transcription tetraurelia ARP32462_P050 MED1_XENLA subunit 1 (Mediator complex subunit 1) Xenopus laevis (African clawed frog) 1570 92.00% MTHFD2 ARP46160_P050 Q6IP36_XENLA MGC78982 protein Xenopus laevis (African clawed frog) 335 78.00% MTHFD2 ARP46160_P050 Q6DDQ6_XENLA Mthfd2‐prov protein Xenopus laevis (African clawed frog) 335 78.00% MTHFD2 ARP46160_P050 Q2VPP2_XENLA MGC78982 protein Xenopus laevis (African clawed frog) 335 78.00% Xenopus tropicalis (Western clawed frog) MTHFD2 ARP46160_P050 B3DL74_XENTR LOC100170462 protein (Silurana tropicalis) 335 78.00% Xenopus tropicalis (Western clawed frog) psmc3ip ARP47615_P050 B2RZG2_XENTR LOC100170440 protein (Silurana tropicalis) 214 100.00%

Homologous‐pairing protein 2 homolog (PSMC3‐interacting protein) (Proteasome 26S psmc3ip ARP47615_P050 HOP2_XENLA ATPase subunit 3‐interacting protein) Xenopus laevis (African clawed frog) 214 100.00% ARP54826_P050 Q7ZTM0_XENLA Cct5‐prov protein Xenopus laevis (African clawed frog) 541 85.00% Chaperonin containing TCP1, subunit 5 Xenopus tropicalis (Western clawed frog) ARP54826_P050 Q6P2Y0_XENTR (Epsilon) (Silurana tropicalis) 541 85.00% smad5 ARP32006_P050 Q91693_XENLA Mothers against DPP Xenopus laevis (African clawed frog) 464 80.00% smad5 ARP32006_P050 Q6PF32_XENLA Xmad protein Xenopus laevis (African clawed frog) 464 80.00% Xenopus tropicalis (Western clawed frog) smad5 ARP32006_P050 Q6DIS7_XENTR SMAD family member 1 (Silurana tropicalis) 464 80.00% smad5 ARP32006_P050 Q91913_XENLA Mad1 protein Xenopus laevis (African clawed frog) 464 80.00% smad5 ARP32006_P050 Q5HZ76_XENLA MADH1 protein Xenopus laevis (African clawed frog) 464 80.00% smad5 ARP32006_P050 P79947_XENLA Smad1.1 Xenopus laevis (African clawed frog) 467 80.00%

ARP51293_P050 Q90X57_XENLA P2Y1 nucleotide receptor (p2ry1‐A protein) Xenopus laevis (African clawed frog) 361 92.00% Xenopus tropicalis (Western clawed frog) ARP51293_P050 Q0V9S6_XENTR LOC100124773 protein (Silurana tropicalis) 361 92.00%

Ordered Locus Names:Maqu_2399OrganismMarinoba cter aquaeolei (strain ATCC 700491 / DSM 11845 / VT8) (Marinobacter hydrocarbonoclasticus (strain DSM 11845)) ARP33856_P050 Q6DDM7_XENLA Acadl‐prov protein Xenopus laevis (African clawed frog) 444 92.00%

Ordered Locus Names:Maqu_2399OrganismMarinoba cter aquaeolei (strain ATCC 700491 / DSM 11845 / VT8) (Marinobacter hydrocarbonoclasticus (strain DSM Xenopus tropicalis (Western clawed frog) 11845)) ARP33856_P050 Q28BK3_XENTR Acyl‐Coenzyme A dehydrogenase, long chain (Silurana tropicalis) 444 92.00% Xenopus tropicalis (Western clawed frog) usp3 ARP33680_P050 Q6DIF2_XENTR Ubiquitin specific peptidase 3 (Silurana tropicalis) 467 90.00% Xenopus tropicalis (Western clawed frog) usp3 ARP33680_P050 Q28F28_XENTR Ubiquitin specific protease 3 (Silurana tropicalis) 522 90.00% usp3 ARP33680_P050 A0JMV8_XENLA LOC100036785 protein Xenopus laevis (African clawed frog) 522 90.00% csrp1b ARP38027_P050 Q68FI9_XENLA MGC86339 protein Xenopus laevis (African clawed frog) 192 100.00% csrp1b ARP38027_P050 Q66J46_XENLA MGC81964 protein Xenopus laevis (African clawed frog) 192 100.00% Xenopus tropicalis (Western clawed frog) csrp1b ARP38027_P050 Q28IA0_XENTR Cysteine and glycine‐rich protein 2 (Silurana tropicalis) 192 100.00% csrp1b ARP38027_P050 Q9I8J5_XENLA Csrp3‐A‐prov protein (LIM protein) Xenopus laevis (African clawed frog) 194 85.00% Xenopus tropicalis (Western clawed frog) csrp1b ARP38027_P050 Q6DF32_XENTR Cysteine and glycine‐rich protein 2 (Silurana tropicalis) 194 78.00% ORF Names:zgc:173721 EMBL AAI52144.1 ZFIN ZDB‐GENE‐071004‐ 63OrganismDanio rerio (Zebrafish) Xenopus tropicalis (Western clawed frog) (Brachydanio rerio) ARP47573_P050 A9UMA2_XENTR LOC100135287 protein (Silurana tropicalis) 327 85.00% ORF Names:zgc:173721 EMBL AAI52144.1 ZFIN ZDB‐GENE‐071004‐ 63OrganismDanio rerio (Zebrafish) Novel protein (Putative Xenopus tropicalis (Western clawed frog) (Brachydanio rerio) ARP47573_P050 Q28EA2_XENTR uncharacterized protein LOC548732) (Silurana tropicalis) 336 85.00% ORF Names:zgc:173721 EMBL AAI52144.1 ZFIN ZDB‐GENE‐071004‐ 63OrganismDanio rerio (Zebrafish) Xenopus tropicalis (Western clawed frog) (Brachydanio rerio) ARP47573_P050 B0S4Q2_XENTR Putative uncharacterized protein (Silurana tropicalis) 215 85.00% ORF Names:zgc:173721 EMBL AAI52144.1 ZFIN ZDB‐GENE‐071004‐ 63OrganismDanio rerio (Zebrafish) Xenopus tropicalis (Western clawed frog) (Brachydanio rerio) ARP47573_P050 B0JZ29_XENTR LOC548732 protein (Silurana tropicalis) 336 85.00% ORF Names:zgc:173721 EMBL AAI52144.1 ZFIN ZDB‐GENE‐071004‐ 63OrganismDanio rerio (Zebrafish) Xenopus tropicalis (Western clawed frog) (Brachydanio rerio) ARP47573_P050 Q0VFM4_XENTR LOC779513 protein (Fragment) (Silurana tropicalis) 222 78.00% ORF Names:zgc:173721 EMBL AAI52144.1 ZFIN ZDB‐GENE‐071004‐ 63OrganismDanio rerio (Zebrafish) (Brachydanio rerio) ARP47573_P050 Q5U4M3_XENLA LOC495467 protein (Fragment) Xenopus laevis (African clawed frog) 581 85.00% ORF Names:zgc:173721 EMBL AAI52144.1 ZFIN ZDB‐GENE‐071004‐ 63OrganismDanio rerio (Zebrafish) Xenopus tropicalis (Western clawed frog) (Brachydanio rerio) ARP47573_P050 B0JZ14_XENTR LOC100145140 protein (Silurana tropicalis) 344 78.00% Ordered Locus Names:Hbut_0008OrganismHyperther mus butylicus (strain DSM 5456 / JCM Transcription factor Sox‐5 (SRY (sex Xenopus tropicalis (Western clawed frog) 9403) ARP33323_P050 SOX5_XENTR determining region Y)‐box 5) (Silurana tropicalis) 753 84.00% Transcription factor Sox‐5 (SRY (sex Xenopus tropicalis (Western clawed frog) ARP51360_P050 SOX5_XENTR determining region Y)‐box 5) (Silurana tropicalis) 753 84.00% Xenopus tropicalis (Western clawed frog) itpk1 ARP54993_P050 A0JM67_XENTR Itpk1 protein (Silurana tropicalis) 396 78.00% Inositol‐tetrakisphosphate 1‐kinase (EC 2.7.1.134) (Inositol 1,3,4‐trisphosphate 5/6‐ kinase) (Inositol‐triphosphate 5/6‐kinase) itpk1 ARP54993_P050 ITPK1_XENLA (Ins(1,3,4)P(3) 5/6‐kinase) (EC 2.7.1.159) Xenopus laevis (African clawed frog) 396 78.00% TBX5 ARP33402_P050 B7ZRZ7_XENLA T‐box transcription factor Tbx5 Xenopus laevis (African clawed frog) 519 83.00% T‐box transcription factor TBX5 (T‐box protein Xenopus tropicalis (Western clawed frog) TBX5 ARP33402_P050 TBX5_XENTR 5) (Silurana tropicalis) 519 83.00% T‐box transcription factor TBX5 (T‐box protein TBX5 ARP33402_P050 TBX5_XENLA 5) Xenopus laevis (African clawed frog) 519 83.00% ORF Names:ACLA_090800 EMBL EAW11387.1OrganismAspergillus clavatus ARP51353_P050 Q8AVP8_XENLA Cyp‐7‐prov protein Xenopus laevis (African clawed frog) 164 92.00% ORF Names:ACLA_090800 EMBL EAW11387.1OrganismAspergillus clavatus ARP51353_P050 Q7SZ12_XENLA CypA protein (Fragment) Xenopus laevis (African clawed frog) 193 92.00% ORF Names:ACLA_090800 EMBL EAW11387.1OrganismAspergillus Peptidylprolyl cis‐trans (EC 5.2.1.8) clavatus ARP51353_P050 Q70YG6_XENLA (Fragment) Xenopus laevis (African clawed frog) 157 92.00% ORF Names:ACLA_090800 EMBL EAW11387.1OrganismAspergillus Xenopus tropicalis (Western clawed frog) clavatus ARP51353_P050 Q6PBF3_XENTR Putative uncharacterized protein MGC75715 (Silurana tropicalis) 164 92.00% ORF Names:ACLA_090800 EMBL EAW11387.1OrganismAspergillus clavatus ARP51353_P050 Q6NUH4_XENLA CypA protein (Fragment) Xenopus laevis (African clawed frog) 192 92.00% ORF Names:ACLA_090800 EMBL EAW11387.1OrganismAspergillus clavatus ARP51353_P050 Q6DTN6_XENLA Cyclophilin A (CypA protein) Xenopus laevis (African clawed frog) 164 92.00% ORF Names:ACLA_090800 EMBL EAW11387.1OrganismAspergillus Xenopus tropicalis (Western clawed frog) clavatus ARP51353_P050 Q66JH4_XENTR MGC79544 protein (Silurana tropicalis) 105 92.00% ORF Names:ACLA_090800 EMBL EAW11387.1OrganismAspergillus clavatus ARP51353_P050 Q0IH13_XENLA MGC154898 protein Xenopus laevis (African clawed frog) 294 92.00% ORF Names:ACLA_090800 EMBL EAW11387.1OrganismAspergillus clavatus ARP51353_P050 A8E5Z6_XENLA LOC100126631 protein (Fragment) Xenopus laevis (African clawed frog) 197 92.00% Xenopus tropicalis (Western clawed frog) thyn1 ARP54988_P050 B2RZE6_XENTR Thyn1 protein (Silurana tropicalis) 224 78.00% Queuine tRNA‐ribosyltransferase subunit qtrtd1 (EC 2.4.2.29) (Queuine tRNA‐ ribosyltransferase domain‐containing protein Xenopus tropicalis (Western clawed frog) QTRTD1 ARP48903_P050 QTRD1_XENTR 1) (Silurana tropicalis) 413 83.00% Queuine tRNA‐ribosyltransferase subunit qtrtd1 (EC 2.4.2.29) (Queuine tRNA‐ ribosyltransferase domain‐containing protein QTRTD1 ARP48903_P050 QTRD1_XENLA 1) Xenopus laevis (African clawed frog) 415 83.00% ORF Names:TVAG_075420 EMBL EAX96736.1OrganismTrichomonas Xenopus tropicalis (Western clawed frog) vaginalis ARP48281_P050 Q6P8F2_XENTR Peroxiredoxin 2 (Silurana tropicalis) 206 85.00% ORF Names:TVAG_075420 EMBL EAX96736.1OrganismTrichomonas vaginalis ARP48281_P050 Q6GNH9_XENLA MGC82793 protein Xenopus laevis (African clawed frog) 267 78.00% ORF Names:TVAG_075420 EMBL EAX96736.1OrganismTrichomonas Xenopus tropicalis (Western clawed frog) vaginalis ARP48281_P050 Q6DFP2_XENTR Peroxiredoxin 4 (Silurana tropicalis) 271 78.00% ORF Names:TVAG_075420 EMBL EAX96736.1OrganismTrichomonas vaginalis ARP48281_P050 Q5PPT1_XENLA LOC496089 protein Xenopus laevis (African clawed frog) 268 78.00% ORF Names:TVAG_075420 EMBL EAX96736.1OrganismTrichomonas vaginalis ARP48281_P050 Q6ING3_XENLA MGC83078 protein Xenopus laevis (African clawed frog) 202 91.00% ORF Names:TVAG_075420 EMBL EAX96736.1OrganismTrichomonas Xenopus tropicalis (Western clawed frog) vaginalis ARP48281_P050 B0JZS0_XENTR LOC100145226 protein (Silurana tropicalis) 201 76.00% ORF Names:TVAG_075420 EMBL EAX96736.1OrganismTrichomonas vaginalis ARP48281_P050 Q6GM49_XENLA MGC83969 protein Xenopus laevis (African clawed frog) 251 78.00% ORF Names:TVAG_075420 EMBL EAX96736.1OrganismTrichomonas Xenopus tropicalis (Western clawed frog) vaginalis ARP48281_P050 Q5BKI4_XENTR Prdx3 protein (Silurana tropicalis) 243 78.00% ORF Names:TVAG_075420 EMBL EAX96736.1OrganismTrichomonas vaginalis ARP48281_P050 Q4FZP9_XENLA MGC116466 protein Xenopus laevis (African clawed frog) 251 78.00% PsHNF3a ARP57867_P050 A1A5K1_XENLA LOC100125667 protein Xenopus laevis (African clawed frog) 200 91.00%

Forkhead box protein A1‐A (FoxA1a) (Fork head domain‐related protein 7) (xFD‐7) (Hepatocyte nuclear factor 3‐alpha homolog PsHNF3a ARP57867_P050 FXA1A_XENLA A) (HNF3alpha homolog A) (xHNF3alpha‐A) Xenopus laevis (African clawed frog) 429 91.00% Xenopus tropicalis (Western clawed frog) PsHNF3a ARP57867_P050 FOXA1_XENTR Forkhead box protein A1 (FoxA1) (tFoxA1) (Silurana tropicalis) 428 91.00% Xenopus tropicalis (Western clawed frog) ARP34587_P050 HDAC8_XENTR Histone deacetylase 8 (HD8) (EC 3.5.1.98) (Silurana tropicalis) 369 92.00% ARP34587_P050 HDAC8_XENLA Histone deacetylase 8 (HD8) (EC 3.5.1.98) Xenopus laevis (African clawed frog) 325 92.00% PARD6B ARP42919_P050 Q9IAS9_XENLA PAR‐6 Xenopus laevis (African clawed frog) 377 78.00% Par‐6 partitioning defective 6 homolog beta Xenopus tropicalis (Western clawed frog) PARD6B ARP42919_P050 Q28IH2_XENTR (C. elegans) (Fragment) (Silurana tropicalis) 364 78.00% Xenopus tropicalis (Western clawed frog) PARD6B ARP42919_P050 B3DM40_XENTR Pard6b protein (Silurana tropicalis) 377 78.00% Hepatocyte nuclear factor 4‐alpha (HNF‐4‐ alpha) ( subfamily 2 group A HNF4G ARP31947_P050 HNF4A_XENLA member 1) Xenopus laevis (African clawed frog) 464 84.00% Ahcyl2 ARP33131_P050 Q6AZU3_XENLA MGC79134 protein Xenopus laevis (African clawed frog) 583 78.00% Ahcyl2 ARP33131_P050 Q68EX1_XENLA MGC84148 protein Xenopus laevis (African clawed frog) 588 78.00%

Novel protein similar to S‐ adenosylhomocysteine ‐like 1 (S‐ Xenopus tropicalis (Western clawed frog) Ahcyl2 ARP33131_P050 Q5BL43_XENTR adenosylhomocysteine hydrolase‐like 1) (Silurana tropicalis) 588 78.00% angptl2 ARP54835_P050 Q08B51_XENLA LOC100158351 protein Xenopus laevis (African clawed frog) 455 85.00% Xenopus tropicalis (Western clawed frog) angptl2 ARP54835_P050 A4IH09_XENTR Angptl2 protein (Silurana tropicalis) 493 85.00% angptl2 ARP54835_P050 A0JPG2_XENLA Angptl2a protein Xenopus laevis (African clawed frog) 493 85.00% KIF3A ARP33917_P050 Q98TI1_XENLA Minesin‐like protein Xenopus laevis (African clawed frog) 699 92.00% LOC559136 ARP43188_P050 Q498F1_XENLA MGC115523 protein Xenopus laevis (African clawed frog) 1750 92.00% Xenopus tropicalis (Western clawed frog) LOC559136 ARP43188_P050 B3DM65_XENTR Ubr2 protein (Fragment) (Silurana tropicalis) 1739 92.00% ARP47650_P050 B7ZRS8_XENLA Meis1 protein Xenopus laevis (African clawed frog) 465 85.00% ARP47650_P050 MEIS1_XENLA Isoform 2 (Isoform XMeis1‐2) (Isoform b) Xenopus laevis (African clawed frog) 465 85.00% ARP47650_P050 MEIS1_XENLA Homeobox protein Meis1 (XMeis1) Xenopus laevis (African clawed frog) 390 85.00% Xenopus tropicalis (Western clawed frog) ARP47650_P050 A0JPD2_XENTR Meis2 protein (Silurana tropicalis) 368 91.00% ARP47650_P050 MEI3A_XENLA Isoform 2 Xenopus laevis (African clawed frog) 385 91.00% Xenopus tropicalis (Western clawed frog) ARP47650_P050 MEIS3_XENTR Homeobox protein meis3 (Silurana tropicalis) 453 91.00% ARP47650_P050 MEI3B_XENLA Homeobox protein meis3‐B Xenopus laevis (African clawed frog) 451 91.00% ARP47650_P050 MEI3A_XENLA Homeobox protein meis3‐A (XMeis3) Xenopus laevis (African clawed frog) 453 91.00% Novel protein containing three RNA recognition motifs. (A.k.a. RRM, RBD, or RNP Xenopus tropicalis (Western clawed frog) myef2 ARP32738_P050 Q28EQ8_XENTR domain) (Fragment) (Silurana tropicalis) 617 100.00% Xenopus tropicalis (Western clawed frog) myef2 ARP32738_P050 B1H2J9_XENTR Myelin expression factor 2 (Silurana tropicalis) 616 100.00% myef2 ARP32738_P050 Q32NK0_XENLA MGC131089 protein Xenopus laevis (African clawed frog) 673 92.00%

ORF Names:zgc:158234 ZFIN ZDB‐GENE‐ 070112‐2352OrganismDanio rerio (Zebrafish) (Brachydanio rerio) ARP47635_P050 Q4V7S1_XENLA MGC115437 protein Xenopus laevis (African clawed frog) 249 100.00% dbi ARP33135_P050 Q6GND4_XENLA Dbia protein Xenopus laevis (African clawed frog) 85 84.00% dbi ARP33135_P050 A1A638_XENLA Dbib protein Xenopus laevis (African clawed frog) 116 83.00% supt5h ARP33386_P050 Q4QQX9_XENLA LOC733281 protein (Fragment) Xenopus laevis (African clawed frog) 610 92.00% Xenopus tropicalis (Western clawed frog) supt5h ARP33386_P050 B3DLU7_XENTR Supt5h protein (Silurana tropicalis) 1078 92.00% supt5h ARP33386_P050 A1L1H7_XENLA LOC733281 protein Xenopus laevis (African clawed frog) 1083 92.00% ARP49632_P050 Q860X9_XENLA Bat5‐prov protein Xenopus laevis (African clawed frog) 554 84.00% Xenopus tropicalis (Western clawed frog) ARP49632_P050 Q6DIG9_XENTR HLA‐B associated transcript 5 (Silurana tropicalis) 553 84.00% ARP49632_P050 Q6DCW6_XENLA Bat5‐prov protein Xenopus laevis (African clawed frog) 553 84.00% Xenopus tropicalis (Western clawed frog) ARP49632_P050 Q28G35_XENTR HLA‐B associated transcript 5 (Silurana tropicalis) 572 84.00% ORF Names:CpipJ_CPIJ018129 EMBL EDS27828.1OrganismCulex quinquefasciatus (Southern house ) (Culex pungens) P100963_P050 Q6PHW7_XENLA Tceb1‐prov protein Xenopus laevis (African clawed frog) 112 100.00% ORF Names:CpipJ_CPIJ018129 EMBL EDS27828.1OrganismCulex quinquefasciatus (Southern house Transcription elongation factor B (SIII), Xenopus tropicalis (Western clawed frog) mosquito) (Culex pungens) P100963_P050 Q28H26_XENTR polypeptide 1 (15kDa, elongin C) (Silurana tropicalis) 112 100.00% EIF4E1B ARP40377_P050 Q6AZE6_XENLA Eif4e protein Xenopus laevis (African clawed frog) 231 100.00% Xenopus tropicalis (Western clawed frog) EIF4E1B ARP40377_P050 Q28CE6_XENTR Eukaryotic initiation factor 4E (Silurana tropicalis) 214 100.00% Eukaryotic translation initiation factor 4E (eIF‐ 4E) (eIF4E) (eIF‐4F 25 kDa subunit) (mRNA cap‐ EIF4E1B ARP40377_P050 IF4E_XENLA binding protein) Xenopus laevis (African clawed frog) 213 100.00% Xenopus tropicalis (Western clawed frog) EIF4E1B ARP40377_P050 B0JZZ9_XENTR Putative uncharacterized protein (Fragment) (Silurana tropicalis) 215 92.00% Xenopus tropicalis (Western clawed frog) EIF4E1B ARP40377_P050 A8WH32_XENTR LOC100127761 protein (Fragment) (Silurana tropicalis) 199 92.00% EIF4E1B ARP40377_P050 Q5HZ86_XENLA MGC85107 protein Xenopus laevis (African clawed frog) 213 92.00% ntrk2b ARP51318_P050 Q9YH44_XENLA Neurotrophin receptor B xTrkB‐alpha Xenopus laevis (African clawed frog) 821 84.00% ntrk2b ARP51318_P050 Q9YH43_XENLA Neurotrophin receptor B xTrkB‐alpha Xenopus laevis (African clawed frog) 811 84.00% Neurotrophin receptor B xTrkB‐beta ntrk2b ARP51318_P050 Q9PST9_XENLA (Fragment) Xenopus laevis (African clawed frog) 486 84.00% Xenopus tropicalis (Western clawed frog) ntrk2b ARP51318_P050 Q08D53_XENTR Neurotrophic tyrosine kinase, receptor, type 2 (Silurana tropicalis) 821 84.00% Xenopus tropicalis (Western clawed frog) atg4b ARP34434_P050 Q0D2E6_XENTR Cysteine endopeptidase AUT‐like (1O128) (Silurana tropicalis) 384 78.00%

Cysteine protease ATG4B (EC 3.4.22.‐) atg4b ARP34434_P050 ATG4B_XENLA (Autophagy‐related protein 4 homolog B) Xenopus laevis (African clawed frog) 384 78.00% ORF Names:PPSIR1_10745 EMBL EDM79075.1OrganismPlesiocystis Xenopus tropicalis (Western clawed frog) pacifica SIR‐1 ARP32073_P050 B3DLZ2_XENTR LOC100170577 protein (Fragment) (Silurana tropicalis) 171 90.00% ORF Names:PROPEN_04239 EMBL EEG83474.1OrganismProteus penneri Serine/threonine‐protein kinase Chk1 (xChk1) ATCC 35198 ARP32589_P050 CHK1_XENLA (EC 2.7.11.1) Xenopus laevis (African clawed frog) 474 76.00%

ORF Names:v1g198706OrganismNematostel la vectensis (Starlet sea anemone) ARP43748_P050 Q7ZTP9_XENLA Slc25a20‐prov protein Xenopus laevis (African clawed frog) 301 92.00%

ORF Names:v1g198706OrganismNematostel Xenopus tropicalis (Western clawed frog) la vectensis (Starlet sea anemone) ARP43748_P050 Q6P628_XENTR Carnitine/acylcarnitine (Silurana tropicalis) 301 92.00%

ORF Names:v1g198706OrganismNematostel la vectensis (Starlet sea anemone) ARP43748_P050 Q5U4N6_XENLA LOC495458 protein Xenopus laevis (African clawed frog) 301 92.00% ARP31643_P050 Q6GMD8_XENLA MGC81839 protein Xenopus laevis (African clawed frog) 245 92.00% Xenopus tropicalis (Western clawed frog) emx2 ARP31643_P050 B5DFT1_XENTR Emx2 protein (Silurana tropicalis) 247 92.00% ORF Names:NFIA_062390 EMBL EAW21078.1OrganismNeosartorya fischeri (strain ATCC 1020 / DSM 3700 / FGSC A1164 / NRRL 181) (Aspergillus Ggps1 (Putative uncharacterized protein Xenopus tropicalis (Western clawed frog) fischerianus) ARP48534_P050 Q28GZ4_XENTR LOC549876) (Silurana tropicalis) 296 92.00% ORF Names:NFIA_062390 EMBL EAW21078.1OrganismNeosartorya fischeri (strain ATCC 1020 / DSM 3700 / FGSC A1164 / NRRL 181) (Aspergillus fischerianus) ARP48534_P050 A3KNC6_XENLA LOC100049104 protein Xenopus laevis (African clawed frog) 296 92.00% BRCA1‐A complex subunit MERIT40 (Mediator of RAP80 interactions and targeting subunit of 40 kDa) (New component of the BRCA1‐A Xenopus tropicalis (Western clawed frog) MERIT40 ARP54986_P050 MRI40_XENTR complex) (Silurana tropicalis) 318 92.00% BRCA1‐A complex subunit MERIT40 (Mediator of RAP80 interactions and targeting subunit of 40 kDa) (New component of the BRCA1‐A MERIT40 ARP54986_P050 MRI40_XENLA complex) Xenopus laevis (African clawed frog) 328 92.00% IRF2 P100613_P050 Q6DED7_XENLA Irf2‐prov protein Xenopus laevis (African clawed frog) 344 85.00% Interferon regulatory factor 2 (Novel protein similar to interferon regulatory factor Xenopus tropicalis (Western clawed frog) IRF2 P100613_P050 Q66JJ2_XENTR transcription factor) (Silurana tropicalis) 347 85.00% IRF2 P100613_P050 Q5PQ39_XENLA LOC495990 protein Xenopus laevis (African clawed frog) 347 85.00% Xenopus tropicalis (Western clawed frog) LOC548770 ARP49860_P050 B2GUI5_XENTR Putative uncharacterized protein LOC548770 (Silurana tropicalis) 204 100.00% LOC548770 ARP49860_P050 CL049_XENLA UPF0454 protein C12orf49 homolog Xenopus laevis (African clawed frog) 205 100.00% Class E basic helix‐loop‐helix protein 22 (bHLHe22) (Class B basic helix‐loop‐helix Xenopus tropicalis (Western clawed frog) ARP32430_P050 BHE22_XENTR protein 5) (bHLHb5) (Silurana tropicalis) 296 93.00% ARP57907_P050 Q66J14_XENLA MGC83414 protein Xenopus laevis (African clawed frog) 440 100.00%

Transcription factor AP‐2 beta (Activating Xenopus tropicalis (Western clawed frog) tfap2b ARP57907_P050 Q28C75_XENTR enhancer binding protein 2 beta) (Silurana tropicalis) 441 100.00% Xenopus tropicalis (Western clawed frog) ARP54884_P050 Q28CG5_XENTR Novel protein similar to GTP‐binding protein 4 (Silurana tropicalis) 388 78.00% ORF Names:OsI_29091 EMBL EAZ06856.1OrganismOryza sativa subsp. indica (Rice) ARP34271_P050 Q6PA56_XENLA LOC398959 protein (Fragment) Xenopus laevis (African clawed frog) 449 100.00% ORF Names:OsI_29091 EMBL EAZ06856.1OrganismOryza sativa subsp. indica (Rice) ARP34271_P050 Q6GN66_XENLA MGC82994 protein Xenopus laevis (African clawed frog) 539 100.00% ORF Names:OsI_29091 EMBL EAZ06856.1OrganismOryza sativa Xenopus tropicalis (Western clawed frog) subsp. indica (Rice) ARP34271_P050 Q6DF03_XENTR Chaperonin containing TCP1, subunit 4 (Delta) (Silurana tropicalis) 542 100.00% ORF Names:OsI_29091 EMBL EAZ06856.1OrganismOryza sativa subsp. indica (Rice) ARP34271_P050 Q5XGW4_XENLA LOC398959 protein Xenopus laevis (African clawed frog) 541 100.00% ORF Names:OsI_29091 EMBL EAZ06856.1OrganismOryza sativa Xenopus tropicalis (Western clawed frog) subsp. indica (Rice) ARP34271_P050 Q28H67_XENTR Chaperonin containing TCP1, subunit 4 (Delta) (Silurana tropicalis) 542 100.00% LOC100036778 ARP54825_P050 Q7ZTM0_XENLA Cct5‐prov protein Xenopus laevis (African clawed frog) 541 100.00% Chaperonin containing TCP1, subunit 5 Xenopus tropicalis (Western clawed frog) LOC100036778 ARP54825_P050 Q6P2Y0_XENTR (Epsilon) (Silurana tropicalis) 541 100.00% LOC100036778 ARP54825_P050 A0AUT4_XENLA LOC100036778 protein Xenopus laevis (African clawed frog) 533 100.00% med17 ARP34192_P050 A6H8I7_XENLA LOC100101325 protein Xenopus laevis (African clawed frog) 640 83.00%

Mediator of RNA polymerase II transcription subunit 17 ( required for Sp1 transcriptional activation subunit 6) (CRSP complex subunit 6) (Mediator complex Xenopus tropicalis (Western clawed frog) med17 ARP34192_P050 MED17_XENTR subunit 17) (Silurana tropicalis) 639 83.00% ORF Names:PANDA_010307 EMBL EFB12976.1OrganismAiluropoda melanoleuca (Giant panda) ARP32666_P050 Q801P6_XENLA LOC398578 protein (Fragment) Xenopus laevis (African clawed frog) 854 91.00% ORF Names:PANDA_010307 EMBL EFB12976.1OrganismAiluropoda melanoleuca (Giant panda) ARP32666_P050 Q2TAV5_XENLA CBTF122 protein Xenopus laevis (African clawed frog) 902 91.00% ORF Names:PANDA_010307 EMBL Interleukin enhancer‐binding factor 3‐B EFB12976.1OrganismAiluropoda (Double‐stranded RNA‐binding protein 4F.2) melanoleuca (Giant panda) ARP32666_P050 ILF3B_XENLA (DsRNA‐binding protein 4F.2) Xenopus laevis (African clawed frog) 898 91.00% Interleukin enhancer‐binding factor 3‐A ORF Names:PANDA_010307 EMBL (CCAAT box transcription factor subunit) EFB12976.1OrganismAiluropoda (Double‐stranded RNA‐binding protein 4F.1) melanoleuca (Giant panda) ARP32666_P050 ILF3A_XENLA (DsRNA‐binding protein 4F.1) Xenopus laevis (African clawed frog) 897 91.00% Doublesex‐ and mab‐3‐related transcription factor A2 (Doublesex‐ and mab‐3‐related Xenopus tropicalis (Western clawed frog) Dmrt5 ARP33214_P050 DMTA2_XENTR transcription factor 5) (Silurana tropicalis) 437 78.00%

ORF Names:v1g243273OrganismNematostel la vectensis (Starlet sea anemone) ARP54955_P050 Q5U4R8_XENLA LOC495499 protein Xenopus laevis (African clawed frog) 890 92.00%

ORF Names:v1g243273OrganismNematostel la vectensis (Starlet sea anemone) ARP54955_P050 Q5XHG0_XENLA LOC495010 protein Xenopus laevis (African clawed frog) 889 78.00% Xenopus tropicalis (Western clawed frog) akap17a ARP34208_P050 B5DDV5_XENTR Sfrs17a protein (Silurana tropicalis) 317 92.00% Xenopus tropicalis (Western clawed frog) kif19 ARP34084_P050 B1WAS1_XENTR LOC100145702 protein (Silurana tropicalis) 405 92.00% kif19 ARP34084_P050 KIF19_XENLA Kinesin‐like protein KIF19 Xenopus laevis (African clawed frog) 997 92.00% YBX1 ARP34395_P050 Q8AVK9_XENLA Nsep1 protein Xenopus laevis (African clawed frog) 304 100.00% YBX1 ARP34395_P050 A1L3K8_XENLA LOC100037035 protein Xenopus laevis (African clawed frog) 322 100.00% YBX1 ARP34395_P050 YB3_XENLA B box‐binding protein (Protein YB3) Xenopus laevis (African clawed frog) 305 100.00% YBX1 ARP34395_P050 Q8AVY9_XENLA Ybx1 protein Xenopus laevis (African clawed frog) 303 92.00% Nuclease sensitive element binding protein 1 Xenopus tropicalis (Western clawed frog) YBX1 ARP34395_P050 Q28IU4_XENTR () (Silurana tropicalis) 306 92.00% Nuclease‐sensitive element‐binding protein 1 (Y‐box transcription factor) (Y‐box‐binding YBX1 ARP34395_P050 YBOX1_XENLA protein 1) (YB‐1) Xenopus laevis (African clawed frog) 303 92.00% Cdc42ep4 ARP54839_P050 Q6NRU4_XENLA MGC81381 protein Xenopus laevis (African clawed frog) 300 92.00% CDC42 effector protein (Rho GTPase binding) Xenopus tropicalis (Western clawed frog) Cdc42ep4 ARP54839_P050 Q28IQ8_XENTR 4 (Cdc42ep4 protein) (Silurana tropicalis) 305 92.00% Cdc42ep4 ARP54839_P050 A2RVB7_XENLA LOC100037164 protein Xenopus laevis (African clawed frog) 302 85.00% Proteasome (Prosome, macropain) 26S Xenopus tropicalis (Western clawed frog) PIPSL ARP32341_P050 Q6NVQ2_XENTR subunit, non‐ATPase, 4 (Silurana tropicalis) 377 85.00% PIPSL ARP32341_P050 Q7ZTP3_XENLA Xrpn10c protein (Fragment) Xenopus laevis (African clawed frog) 387 85.00% 26S proteasome subunit (Proteasome subunit PIPSL ARP32341_P050 Q588Y7_XENLA xrpn10) Xenopus laevis (African clawed frog) 376 85.00% PIPSL ARP32341_P050 Q4V845_XENLA Xrpn10c protein Xenopus laevis (African clawed frog) 376 85.00% ORF Names:PANDA_001344 EMBL EFB23050.1OrganismAiluropoda Xenopus tropicalis (Western clawed frog) melanoleuca (Giant panda) ARP33808_P050 Q5GH20_XENTR XK‐related 2 (Silurana tropicalis) 437 100.00% Xenopus tropicalis (Western clawed frog) PTK2B ARP32685_P050 Q5XH98_XENTR PTK2B protein tyrosine kinase 2 beta (Silurana tropicalis) 859 92.00% C130057N11Rik ARP34074_P050 Q8AVP9_XENLA Hnrpc‐prov protein Xenopus laevis (African clawed frog) 263 84.00% Heterogeneous nuclear ribonucleoprotein C Xenopus tropicalis (Western clawed frog) C130057N11Rik ARP34074_P050 Q6DET1_XENTR (C1/C2) (Silurana tropicalis) 283 84.00%

Heterogeneous nuclear ribonucleoprotein C C130057N11Rik ARP34074_P050 HNRPC_XENLA (hnRNP C) (hnRNP core protein C) Xenopus laevis (African clawed frog) 282 84.00% ORF Names:GSPATT00008167001 EMBL CAK71619.1OrganismParamecium tetraurelia ARP51477_P050 Q68F23_XENLA MGC82288 protein Xenopus laevis (African clawed frog) 443 92.00% ORF Names:GSPATT00008167001 EMBL CAK71619.1OrganismParamecium Xenopus tropicalis (Western clawed frog) tetraurelia ARP51477_P050 A9UMD5_XENTR LOC100135319 protein (Silurana tropicalis) 443 85.00% ARP32135_P050 Q8AWF3_XENLA Muscle regulatory factor 4b (Fragment) Xenopus laevis (African clawed frog) 171 100.00% ARP32135_P050 Q5U4S0_XENLA LOC495450 protein (MRF4b) Xenopus laevis (African clawed frog) 241 100.00% ARP32135_P050 B7ZQB0_XENLA MRF4a Xenopus laevis (African clawed frog) 240 100.00% Xenopus tropicalis (Western clawed frog) ARP32135_P050 A8E5S2_XENTR Myogenic factor 6 (Herculin) (Silurana tropicalis) 241 100.00% ARP32135_P050 A7UCI1_XENLA MRF4a (Muscle regulatory factor 4a) Xenopus laevis (African clawed frog) 240 100.00% Myogenic factor 6 (Myf‐6) (Muscle‐specific ARP32135_P050 MYF6_XENLA regulatory factor 4) Xenopus laevis (African clawed frog) 240 100.00% ARP32135_P050 B7ZRD6_XENLA Myogenic factor Xmyf‐5 Xenopus laevis (African clawed frog) 255 85.00% ARP32135_P050 MYF5_XENLA Myogenic factor 5 (Myf‐5) Xenopus laevis (African clawed frog) 255 85.00% Xenopus tropicalis (Western clawed frog) ARP32135_P050 Q8QG50_XENTR Myogenic factor 5 (Myogenic factor MYF‐5) (Silurana tropicalis) 255 78.00% Xenopus tropicalis (Western clawed frog) ARP32135_P050 Q7T108_XENTR Myf5 protein (Silurana tropicalis) 220 78.00% ARP57903_P050 B7ZQY8_XENLA T‐box transcription factor Tbx2 (Tbx2 protein) Xenopus laevis (African clawed frog) 688 92.00% T‐box transcription factor TBX2 (T‐box protein Xenopus tropicalis (Western clawed frog) tbx3 ARP57903_P050 TBX2_XENTR 2) (Silurana tropicalis) 685 92.00% T‐box transcription factor TBX2‐A (T‐box tbx3 ARP57903_P050 TBX2A_XENLA protein 2‐A) Xenopus laevis (African clawed frog) 688 92.00% tbx3 ARP57903_P050 Q9PUM1_XENLA Transcription repression factor ET Xenopus laevis (African clawed frog) 716 85.00% tbx3 ARP57903_P050 Q9IBC7_XENLA Tbx3 protein (Transcription factor Tbx3) Xenopus laevis (African clawed frog) 711 85.00% Xenopus tropicalis (Western clawed frog) tbx3 ARP57903_P050 Q4KKX3_XENTR T‐box 3 (Silurana tropicalis) 701 85.00% tbx3 ARP57903_P050 B7ZQY4_XENLA Transcription repression factor Tbx3 Xenopus laevis (African clawed frog) 716 85.00% T‐box transcription factor TBX2‐B (T‐box tbx3 ARP57903_P050 TBX2B_XENLA protein 2‐B) Xenopus laevis (African clawed frog) 691 85.00% Xenopus tropicalis (Western clawed frog) tbx3 ARP57903_P050 A9UM63_XENTR LOC100135256 protein (Fragment) (Silurana tropicalis) 287 78.00%

ORF Names:IscW_ISCW010530 EMBL EEC15287.1OrganismIxodes scapularis (Black‐legged tick) (Deer tick) ARP54956_P050 Q5XHG0_XENLA LOC495010 protein Xenopus laevis (African clawed frog) 889 92.00%

ORF Names:IscW_ISCW010530 EMBL EEC15287.1OrganismIxodes scapularis (Black‐legged tick) (Deer tick) ARP54956_P050 Q5U4R8_XENLA LOC495499 protein Xenopus laevis (African clawed frog) 890 92.00%

ORF Names:IscW_ISCW010530 EMBL EEC15287.1OrganismIxodes scapularis (Black‐legged tick) (Deer tick) ARP54956_P050 Q5U4V0_XENLA LOC495494 protein Xenopus laevis (African clawed frog) 890 75.00%

ORF Names:IscW_ISCW010530 EMBL EEC15287.1OrganismIxodes scapularis (Black‐legged tick) (Deer tick) ARP54956_P050 O93335_XENLA Transportin (Fragment) Xenopus laevis (African clawed frog) 885 75.00% ARP34686_P050 PAX8_XENLA Isoform 2 Xenopus laevis (African clawed frog) 403 100.00% Xenopus tropicalis (Western clawed frog) pax8 ARP34686_P050 PAX8_XENTR Paired box protein Pax‐8 (Fragment) (Silurana tropicalis) 458 100.00% pax8 ARP34686_P050 PAX8_XENLA Paired box protein Pax‐8 (XPax‐8) Xenopus laevis (African clawed frog) 465 100.00% Xenopus tropicalis (Western clawed frog) pax8 ARP34686_P050 Q28IR6_XENTR Paired box gene 2 (Silurana tropicalis) 140 92.00% pax8 ARP34686_P050 O57679_XENLA Paired box protein Xenopus laevis (African clawed frog) 252 92.00% pax8 ARP34686_P050 O57676_XENLA Paired box protein Xenopus laevis (African clawed frog) 385 92.00% pax8 ARP34686_P050 PAX5_XENLA Isoform 2 Xenopus laevis (African clawed frog) 424 92.00% pax8 ARP34686_P050 PAX2B_XENLA Isoform 4 (Isoform 11) Xenopus laevis (African clawed frog) 291 92.00% pax8 ARP34686_P050 PAX2B_XENLA Isoform 3 (Isoform 8) Xenopus laevis (African clawed frog) 290 92.00% pax8 ARP34686_P050 PAX2B_XENLA Isoform 2 Xenopus laevis (African clawed frog) 462 92.00% pax8 ARP34686_P050 PAX2A_XENLA Isoform 6 (Isoform 10) Xenopus laevis (African clawed frog) 256 92.00% pax8 ARP34686_P050 PAX2A_XENLA Isoform 5 (Isoform 7) Xenopus laevis (African clawed frog) 329 92.00% pax8 ARP34686_P050 PAX2A_XENLA Isoform 4 (Isoform 5) Xenopus laevis (African clawed frog) 354 92.00% pax8 ARP34686_P050 PAX2A_XENLA Isoform 3 Xenopus laevis (African clawed frog) 427 92.00% pax8 ARP34686_P050 PAX2A_XENLA Isoform 2 (Isoform 1) Xenopus laevis (African clawed frog) 394 92.00% pax8 ARP34686_P050 PAX5_XENLA Paired box protein Pax‐5 (XPax‐5) Xenopus laevis (African clawed frog) 388 92.00% pax8 ARP34686_P050 PAX2B_XENLA Paired box protein Pax‐2‐B (xPax‐2b) Xenopus laevis (African clawed frog) 494 92.00% pax8 ARP34686_P050 PAX2A_XENLA Paired box protein Pax‐2‐A (xPax‐2a) Xenopus laevis (African clawed frog) 497 92.00% ARP47658_P050 Q640Z4_XENLA MGC83916 protein Xenopus laevis (African clawed frog) 624 78.00% Xenopus tropicalis (Western clawed frog) ARP47658_P050 Q5U4R0_XENTR Metastasis associated 1 (Silurana tropicalis) 639 78.00%

ORF Names:zgc:158781 ZFIN ZDB‐GENE‐ 070112‐182OrganismDanio rerio (Zebrafish) (Brachydanio rerio) ARP34270_P050 Q8JH41_XENLA Pax‐9 (Fragment) Xenopus laevis (African clawed frog) 104 100.00%

ORF Names:zgc:158781 ZFIN ZDB‐GENE‐ 070112‐182OrganismDanio rerio (Zebrafish) (Brachydanio rerio) ARP34270_P050 Q5XH51_XENLA Putative uncharacterized protein Xenopus laevis (African clawed frog) 360 100.00%

ORF Names:zgc:158781 ZFIN ZDB‐GENE‐ 070112‐182OrganismDanio rerio (Zebrafish) (Brachydanio rerio) ARP34270_P050 Q0PZI2_XENLA Paired box protein 1 Xenopus laevis (African clawed frog) 358 92.00%

ORF Names:zgc:158781 ZFIN ZDB‐GENE‐ 070112‐182OrganismDanio rerio Xenopus tropicalis (Western clawed frog) (Zebrafish) (Brachydanio rerio) ARP34270_P050 A9UMI7_XENTR Pax1 protein (Fragment) (Silurana tropicalis) 415 84.00% Xenopus tropicalis (Western clawed frog) Phkg2 ARP33072_P050 B1H2F1_XENTR LOC100145409 protein (Silurana tropicalis) 390 92.00% Phkg2 ARP33072_P050 Q5HZR1_XENLA LOC496328 protein Xenopus laevis (African clawed frog) 395 85.00% Xenopus tropicalis (Western clawed frog) Phkg2 ARP33072_P050 Q0VA11_XENTR Putative uncharacterized protein MGC145608 (Silurana tropicalis) 216 85.00% TARDBP ARP35838_P050 Q7ZXS6_XENLA Tardbp‐prov protein Xenopus laevis (African clawed frog) 245 85.00% Xenopus tropicalis (Western clawed frog) TARDBP ARP35838_P050 TADBP_XENTR TAR DNA‐binding protein 43 (TDP‐43) (Silurana tropicalis) 409 85.00% TARDBP ARP35838_P050 Q8JJ42_XENLA Mitotic phosphoprotein 39 Xenopus laevis (African clawed frog) 412 91.00% ppp3cc ARP51337_P050 Q6AXB0_XENLA MGC79144 protein Xenopus laevis (African clawed frog) 511 100.00% Xenopus tropicalis (Western clawed frog) ppp3cc ARP51337_P050 B0BLZ8_XENTR LOC100144934 protein (Silurana tropicalis) 521 100.00% ppp3cc ARP51337_P050 Q9DEF7_XENLA Calcineurin catalytic subunit Xenopus laevis (African clawed frog) 508 92.00% ppp3cc ARP51337_P050 Q801N4_XENLA Ppp3ca‐prov protein Xenopus laevis (African clawed frog) 518 92.00% ppp3cc ARP51337_P050 O57438_XENLA Calcineurin A Xenopus laevis (African clawed frog) 518 92.00% Xenopus tropicalis (Western clawed frog) ppp3cc ARP51337_P050 A4IFW0_XENTR LOC100037857 protein (Silurana tropicalis) 524 78.00% POLR2B ARP32456_P050 Q6PA46_XENLA MGC68569 protein Xenopus laevis (African clawed frog) 949 100.00% syp ARP45435_P050 O57343_XENLA Synaptophysin (Syp‐A protein) Xenopus laevis (African clawed frog) 300 100.00% Xenopus tropicalis (Western clawed frog) syp ARP45435_P050 B0BLZ1_XENTR LOC100144928 protein (Silurana tropicalis) 300 100.00% syp ARP45435_P050 O57344_XENLA Synaptophysin (Syp‐B protein) Xenopus laevis (African clawed frog) 294 92.00% ARP34043_P050 Q6PF63_XENLA MGC68862 protein Xenopus laevis (African clawed frog) 471 85.00% ARP34043_P050 Q4KLA8_XENLA MGC116511 protein Xenopus laevis (African clawed frog) 471 85.00% Cysteine and histidine‐rich domain (CHORD)‐ Xenopus tropicalis (Western clawed frog) CHORDC1 ARP54844_P050 Q6DIX7_XENTR containing, zinc binding protein 1 (Silurana tropicalis) 230 92.00% Cysteine and histidine‐rich domain‐containing protein 1 (CHORD domain‐containing protein CHORDC1 ARP54844_P050 CHRD1_XENLA 1) (Protein morgana) Xenopus laevis (African clawed frog) 334 85.00% Xenopus tropicalis (Western clawed frog) RNF2 ARP34289_P050 B1WAN7_XENTR Ring finger protein 2 (Silurana tropicalis) 336 100.00% LOC100127274 protein (Putative RNF2 ARP34289_P050 A9JSS1_XENLA uncharacterized protein LOC100127274) Xenopus laevis (African clawed frog) 336 100.00% si:dkey‐72g22.1 ARP50557_P050 Q6DKM0_XENLA MGC83065 protein Xenopus laevis (African clawed frog) 1230 85.00% Xenopus tropicalis (Western clawed frog) si:dkey‐72g22.1 ARP50557_P050 Q6DD98_XENTR Cand1 protein (Fragment) (Silurana tropicalis) 175 85.00% RUVBL2 ARP32379_P050 Q801R1_XENLA Ruvbl2‐prov protein Xenopus laevis (African clawed frog) 462 92.00% Xenopus tropicalis (Western clawed frog) RUVBL2 ARP32379_P050 Q6GL37_XENTR RuvB‐like 2 (Silurana tropicalis) 418 92.00% Xenopus tropicalis (Western clawed frog) RUVBL2 ARP32379_P050 Q28GB7_XENTR RuvB‐like 2 (Silurana tropicalis) 462 92.00% RUVBL2 ARP32379_P050 Q0IH85_XENLA LOC398205 protein Xenopus laevis (African clawed frog) 462 92.00% RUVBL2 ARP32379_P050 RUVB2_XENLA RuvB‐like 2 (EC 3.6.4.12) () Xenopus laevis (African clawed frog) 462 92.00% Wingless‐type MMTV integration site family, Wnt5 ARP32128_P050 B7ZQY1_XENLA member 5A Xenopus laevis (African clawed frog) 380 93.00% Wnt5 ARP32128_P050 WNT5A_XENLA Protein Wnt‐5a (XWnt‐5a) Xenopus laevis (African clawed frog) 380 93.00% Wingless‐type MMTV integration site family, Xenopus tropicalis (Western clawed frog) Wnt5 ARP32128_P050 Q6DII0_XENTR member 5B (Silurana tropicalis) 360 86.00%

Wnt5 ARP32128_P050 WNT5B_XENLA Protein Wnt‐5b (Protein Wnt‐5c) (XWnt‐5C) Xenopus laevis (African clawed frog) 360 86.00% Xenopus tropicalis (Western clawed frog) ARP31440_P050 Q6NX18_XENTR X‐box binding protein 1 (Silurana tropicalis) 252 84.00% ARP31440_P050 Q2TAU5_XENLA Xbp1 protein Xenopus laevis (African clawed frog) 254 84.00% Xenopus tropicalis (Western clawed frog) ARP31440_P050 A8KBG5_XENTR LOC100127664 protein (Silurana tropicalis) 909 85.00% Xenopus tropicalis (Western clawed frog) GRM8 ARP32597_P050 A8KBG5_XENTR LOC100127664 protein (Silurana tropicalis) 909 85.00% Nuclear receptor subfamily 2 group E member 1 (Nuclear receptor TLX) (Protein tailless ARP45612_P050 NR2E1_XENLA homolog) (Tll) (xTLL) Xenopus laevis (African clawed frog) 386 100.00% General transcription factor 2F, polypeptide 2, Xenopus tropicalis (Western clawed frog) gtf2f2a ARP31436_P050 Q6P8B7_XENTR 30kDa (Silurana tropicalis) 264 92.00% General transcription factor IIF subunit 2 (EC 3.6.4.12) (ATP‐dependent helicase gtf2f2) (Transcription initiation factor IIF subunit beta) (TFIIF‐beta) (Transcription initiation gtf2f2a ARP31436_P050 T2FB_XENLA factor RAP30) Xenopus laevis (African clawed frog) 264 92.00% HMX2 ARP32629_P050 Q5U4R7_XENLA LOC495452 protein Xenopus laevis (African clawed frog) 266 78.00% HMX2 ARP32629_P050 B7ZPU3_XENLA Nkx‐5.1 homeodomain protein Xenopus laevis (African clawed frog) 306 78.00% Homeobox protein HMX3 (Homeobox protein H6 family member 3) (Homeobox protein Nkx‐ Xenopus tropicalis (Western clawed frog) HMX2 ARP32629_P050 HMX3_XENTR 5.1) (Silurana tropicalis) 306 78.00% Homeobox protein HMX3 (Homeobox protein H6 family member 3) (Homeobox protein Nkx‐ HMX2 ARP32629_P050 HMX3_XENLA 5.1) (X‐nkx‐5.1) Xenopus laevis (African clawed frog) 306 78.00% Pygb ARP48586_P050 A2VDD8_XENLA LOC100037229 protein (Fragment) Xenopus laevis (African clawed frog) 839 92.00% Pygb ARP48586_P050 Q801T6_XENLA Pygm‐prov protein Xenopus laevis (African clawed frog) 843 85.00% Xenopus tropicalis (Western clawed frog) Pygb ARP48586_P050 Q6NV69_XENTR Phosphorylase, glycogen; (Silurana tropicalis) 843 85.00% Pygb ARP48586_P050 Q6INV9_XENLA MGC80198 protein Xenopus laevis (African clawed frog) 843 85.00% Pygb ARP48586_P050 Q63ZG6_XENLA Pygl protein Xenopus laevis (African clawed frog) 855 78.00% Xenopus tropicalis (Western clawed frog) Pygb ARP48586_P050 Q0VFF7_XENTR Pygl protein (Fragment) (Silurana tropicalis) 373 78.00% Map4k2 ARP48632_P050 Q68F04_XENLA MGC83247 protein Xenopus laevis (African clawed frog) 823 83.00% Xenopus tropicalis (Western clawed frog) Map4k2 ARP48632_P050 B3DLY3_XENTR LOC100170570 protein (Silurana tropicalis) 878 83.00% Xenopus tropicalis (Western clawed frog) Map4k2 ARP48632_P050 B4F6N7_XENTR Putative uncharacterized protein (Silurana tropicalis) 861 75.00% MAP4K2 ARP34203_P050 Q68F04_XENLA MGC83247 protein Xenopus laevis (African clawed frog) 823 83.00% Xenopus tropicalis (Western clawed frog) MAP4K2 ARP34203_P050 B3DLY3_XENTR LOC100170570 protein (Silurana tropicalis) 878 83.00% Xenopus tropicalis (Western clawed frog) MAP4K2 ARP34203_P050 B4F6N7_XENTR Putative uncharacterized protein (Silurana tropicalis) 861 75.00% IFT172 ARP51661_P050 Q5FWQ3_XENLA LOC733157 protein (Fragment) Xenopus laevis (African clawed frog) 1201 92.00% LASS3 ARP31648_P050 Q5FWQ3_XENLA LOC733157 protein (Fragment) Xenopus laevis (African clawed frog) 1201 92.00% ORF Names:MED134_04754 EMBL EAQ40034.1OrganismDokdonia donghaensis MED134 ARP43186_P050 Q6P7J2_XENLA MGC68621 protein Xenopus laevis (African clawed frog) 473 92.00% rnf182 ARP43438_P050 Q66KN6_XENLA MGC85578 protein Xenopus laevis (African clawed frog) 246 92.00% Xenopus tropicalis (Western clawed frog) rnf182 ARP43438_P050 A4IHL7_XENTR Rnf182 protein (Silurana tropicalis) 246 92.00% E3 ubiquitin‐protein ligase RNF182 (EC 6.3.2.‐) rnf182 ARP43438_P050 RN182_XENLA (RING finger protein 182) Xenopus laevis (African clawed frog) 246 85.00% Xenopus tropicalis (Western clawed frog) rab14 AVARP13107_P050 Q68FA1_XENTR RAB14, member RAS oncogene family (Silurana tropicalis) 215 100.00% rab14 AVARP13107_P050 Q640I3_XENLA LOC494665 protein Xenopus laevis (African clawed frog) 215 100.00% Xenopus tropicalis (Western clawed frog) sec14l3 ARP31825_P050 B1H184_XENTR LOC100145318 protein (Silurana tropicalis) 410 92.00% sec14l3 ARP31825_P050 A1L2M8_XENLA LOC100036896 protein Xenopus laevis (African clawed frog) 410 92.00% P100775_P050 Q641A7_XENLA Putative uncharacterized protein Xenopus laevis (African clawed frog) 684 92.00% Xenopus tropicalis (Western clawed frog) P100775_P050 B1H316_XENTR LOC100145532 protein (Fragment) (Silurana tropicalis) 196 92.00% Xenopus tropicalis (Western clawed frog) P100775_P050 A4IIL6_XENTR Tcf3 protein (Silurana tropicalis) 655 78.00% P100775_P050 TFE2_XENLA Isoform E47 Xenopus laevis (African clawed frog) 651 78.00% Transcription factor E2‐alpha (Transcription factor 3) (TCF‐3) (Transcription factor P100775_P050 TFE2_XENLA XE12/XE47) Xenopus laevis (African clawed frog) 658 78.00% ARP48587_P050 Q801T6_XENLA Pygm‐prov protein Xenopus laevis (African clawed frog) 843 78.00% ARP48587_P050 Q6INV9_XENLA MGC80198 protein Xenopus laevis (African clawed frog) 843 83.00% ARP48587_P050 A2VDD8_XENLA LOC100037229 protein (Fragment) Xenopus laevis (African clawed frog) 839 83.00% gtf2b ARP58006_P050 Q63ZH4_XENLA LOC494830 protein Xenopus laevis (African clawed frog) 316 100.00% General transcription factor IIBgeneral Xenopus tropicalis (Western clawed frog) gtf2b ARP58006_P050 Q28G23_XENTR transcription factor IIB (Silurana tropicalis) 316 100.00% Transcription initiation factor IIB (General gtf2b ARP58006_P050 TF2B_XENLA transcription factor TFIIB) Xenopus laevis (African clawed frog) 316 100.00% Xenopus tropicalis (Western clawed frog) Cacnb1 ARP34953_P050 B2GU78_XENTR LOC100158521 protein (Silurana tropicalis) 583 100.00%

ORF Names:v1g194333OrganismNematostel la vectensis (Starlet sea anemone) ARP48692_P050 Q4QQP5_XENLA MGC132021 protein (Fragment) Xenopus laevis (African clawed frog) 349 92.00%

ORF Names:v1g194333OrganismNematostel la vectensis (Starlet sea anemone) ARP48692_P050 Q3KPR0_XENLA MGC132021 protein Xenopus laevis (African clawed frog) 358 92.00%

ORF Names:v1g194333OrganismNematostel Xenopus tropicalis (Western clawed frog) la vectensis (Starlet sea anemone) ARP48692_P050 B5DEU3_XENTR Putative uncharacterized protein (Silurana tropicalis) 358 92.00% ORF Names:FB2170_04645 EMBL EAR02546.1OrganismFlavobacteriales Xenopus tropicalis (Western clawed frog) bacterium HTCC2170 ARP30074_P050 B4F6N3_XENTR Putative uncharacterized protein (Fragment) (Silurana tropicalis) 1220 84.00% ORF Names:PVX_122295 EMBL EDL47295.1OrganismPlasmodium vivax (strain Salvador I) ARP57996_P050 A1L2G6_XENLA LOC733246 protein Xenopus laevis (African clawed frog) 506 90.00% Gli‐Kruppel zinc‐finger protein NKL isoform b s37 ARP30037_P050 Q98T93_XENLA (Fragment) Xenopus laevis (African clawed frog) 478 92.00% Zinc finger protein GLIS2 (GLI‐similar 2) s37 ARP30037_P050 GLIS2_XENLA (Neuronal Krueppel‐like protein) Xenopus laevis (African clawed frog) 492 92.00% MAPK14 AVARP06004_P050 Q6GM23_XENLA Mapk14a‐prov protein Xenopus laevis (African clawed frog) 252 92.00% Xenopus tropicalis (Western clawed frog) MAPK14 AVARP06004_P050 Q6DJ17_XENTR Mitogen‐activated protein kinase 14 (Silurana tropicalis) 361 92.00%

MAPK14 AVARP06004_P050 D2KW21_XENLA Mitogen‐activated protein kinase p38 alpha Xenopus laevis (African clawed frog) 361 92.00% Mitogen‐activated protein kinase 14 (MAP kinase 14) (MAPK 14) (EC 2.7.11.24) (Mitogen‐ activated Mitogen‐activated protein kinase 2) MAPK14 AVARP06004_P050 MK14_XENLA (MAP kinase 2) (MPK2) Xenopus laevis (African clawed frog) 361 92.00% Xenopus tropicalis (Western clawed frog) ARP34683_P050 A0JPD2_XENTR Meis2 protein (Silurana tropicalis) 368 100.00%

Homeobox protein EMX1 (Empty spiracles Xenopus tropicalis (Western clawed frog) ARP47536_P050 EMX1_XENTR homolog 1) (Empty spiracles‐like protein 1) (Silurana tropicalis) 233 85.00% ARP47536_P050 Q6AZM1_XENLA Emx1‐prov protein Xenopus laevis (African clawed frog) 240 91.00% Xenopus tropicalis (Western clawed frog) ARP47536_P050 B5DFT1_XENTR Emx2 protein (Silurana tropicalis) 247 78.00% Xenopus tropicalis (Western clawed frog) P100970_P050 B5DEA1_XENTR Putative uncharacterized protein (Silurana tropicalis) 388 76.00%

T‐cell acute lymphocytic leukemia protein 1 P100970_P050 TAL1_XENLA (TAL‐1) (Stem cell leukemia protein SCL) (xSCL) Xenopus laevis (African clawed frog) 394 76.00%

ORF Names:An01g12700 EMBL CAK37320.1OrganismAspergillus niger (strain CBS 513.88 / FGSC A1513) ARP37746_P050 Q5XGW8_XENLA LOC495123 protein Xenopus laevis (African clawed frog) 344 100.00%

ORF Names:An01g12700 EMBL CAK37320.1OrganismAspergillus niger Xenopus tropicalis (Western clawed frog) (strain CBS 513.88 / FGSC A1513) ARP37746_P050 B4F729_XENTR Putative uncharacterized protein (Silurana tropicalis) 356 100.00%

ORF Names:An01g12700 EMBL CAK37320.1OrganismAspergillus niger (strain CBS 513.88 / FGSC A1513) ARP37746_P050 Q91708_XENLA C4SR protein Xenopus laevis (African clawed frog) 337 92.00%

ORF Names:An01g12700 EMBL CAK37320.1OrganismAspergillus niger (strain CBS 513.88 / FGSC A1513) ARP37746_P050 A3KND4_XENLA C4SR protein Xenopus laevis (African clawed frog) 337 92.00% ORF Names:GSPATT00035341001 EMBL CAK66212.1OrganismParamecium Xenopus tropicalis (Western clawed frog) tetraurelia P100701_P050 Q66II2_XENTR Ercc2 protein (Silurana tropicalis) 760 100.00% Xenopus tropicalis (Western clawed frog) ARP34952_P050 A1L1E0_XENTR LOC100036724 protein (Silurana tropicalis) 1076 84.00% FBXO32 ARP43117_P050 Q6INF2_XENLA MGC83150 protein Xenopus laevis (African clawed frog) 351 92.00% Xenopus tropicalis (Western clawed frog) FBXO32 ARP43117_P050 Q569D4_XENTR Fbxo32 protein (Silurana tropicalis) 353 92.00% Ordered Locus Names:Cthe_1968OrganismClostridium thermocellum (strain ATCC 27405 / DSM 1237) ARP35497_P050 Q4V7N5_XENLA MGC115522 protein Xenopus laevis (African clawed frog) 233 85.00% Ordered Locus Names:Cthe_1968OrganismClostridium thermocellum (strain ATCC 27405 / Xenopus tropicalis (Western clawed frog) DSM 1237) ARP35497_P050 A9UM33_XENTR LOC100135241 protein (Silurana tropicalis) 259 92.00% Ordered Locus Names:Cthe_1968OrganismClostridium thermocellum (strain ATCC 27405 / DSM 1237) ARP35497_P050 Q6GM25_XENLA MGC84022 protein Xenopus laevis (African clawed frog) 231 100.00% Ordered Locus Names:Cthe_1968OrganismClostridium thermocellum (strain ATCC 27405 / DSM 1237) ARP35497_P050 Q640X4_XENLA Kcnip2 protein Xenopus laevis (African clawed frog) 231 100.00% RBM39 ARP40560_P050 Q6DD16_XENLA Rnpc2‐prov protein Xenopus laevis (African clawed frog) 540 100.00%

RNA binding motif protein 39 (RNA‐binding Xenopus tropicalis (Western clawed frog) RBM39 ARP40560_P050 Q566M5_XENTR region (RNP1, RRM) containing 2) (Silurana tropicalis) 542 100.00% CYB561 ARP41869_P050 Q6NRZ7_XENLA Cyb561 protein Xenopus laevis (African clawed frog) 214 100.00% CYB561 ARP41869_P050 Q6GMD4_XENLA Cyb561 protein Xenopus laevis (African clawed frog) 247 100.00% Xenopus tropicalis (Western clawed frog) CYB561 ARP41869_P050 Q6GL84_XENTR Cytochrome b‐561 (Silurana tropicalis) 246 100.00% CYB561 ARP41869_P050 CY561_XENLA Cytochrome b561 (Cytochrome b‐561) Xenopus laevis (African clawed frog) 247 100.00%

Vacuolar protein sorting‐associated protein 72 VPS72 ARP34072_P050 VPS72_XENLA homolog (Transcription factor‐like 1) Xenopus laevis (African clawed frog) 353 84.00% Cellular retinoic acid‐binding protein 2 (Cellular retinoic acid‐binding protein) crabp2b ARP41983_P050 RABP2_XENLA (CRABP) (xCRABP) (xCRABP‐b) Xenopus laevis (African clawed frog) 138 92.00% Xenopus tropicalis (Western clawed frog) crabp2b ARP41983_P050 Q6DEX2_XENTR Cellular retinoic acid binding protein 2 (Silurana tropicalis) 138 84.00% Xenopus tropicalis (Western clawed frog) crabp2b ARP41983_P050 B1H2C9_XENTR LOC100145390 protein (Silurana tropicalis) 142 85.00% Xenopus tropicalis (Western clawed frog) Cse1l AVARP00023_P050 B2GU98_XENTR Cse1l protein (Silurana tropicalis) 971 93.00%

Exportin‐2 (Exp2) ( segregation 1‐ Cse1l AVARP00023_P050 XPO2_XENLA like protein) (Importin‐alpha re‐exporter) Xenopus laevis (African clawed frog) 971 93.00% Tox2 ARP30008_P050 Q6DJE3_XENLA MGC84449 protein Xenopus laevis (African clawed frog) 465 76.00% Xenopus tropicalis (Western clawed frog) Tox2 ARP30008_P050 B2GTY3_XENTR Tox2 protein (Fragment) (Silurana tropicalis) 241 76.00% Xenopus tropicalis (Western clawed frog) Tox2 ARP30008_P050 A4IHB6_XENTR Tox2 protein (Fragment) (Silurana tropicalis) 201 76.00% ORF Names:NFIA_015630 EMBL EAW22870.1OrganismNeosartorya fischeri (strain ATCC 1020 / DSM 3700 / FGSC A1164 / NRRL 181) (Aspergillus Xenopus tropicalis (Western clawed frog) fischerianus) ARP30114_P050 Q6NVT6_XENTR Calreticulin (Silurana tropicalis) 416 76.00% Xenopus tropicalis (Western clawed frog) ZNF281 ARP39006_P050 Q28E47_XENTR Zinc finger protein 281 (Fragment) (Silurana tropicalis) 532 76.00% AVARP07031_P050 SDF1_XENLA Isoform Alpha (Isoform xSDF‐1alpha) Xenopus laevis (African clawed frog) 89 100.00% Stromal cell‐derived factor 1 (SDF‐1) (C‐X‐C Xenopus tropicalis (Western clawed frog) AVARP07031_P050 SDF1_XENTR motif chemokine 12) (Silurana tropicalis) 93 100.00% Stromal cell‐derived factor 1 (xSDF‐1) (C‐X‐C AVARP07031_P050 SDF1_XENLA motif chemokine 12) Xenopus laevis (African clawed frog) 94 100.00% SLC1A1 ARP43865_P050 SDF1_XENLA Isoform Alpha (Isoform xSDF‐1alpha) Xenopus laevis (African clawed frog) 89 100.00% Stromal cell‐derived factor 1 (SDF‐1) (C‐X‐C Xenopus tropicalis (Western clawed frog) SLC1A1 ARP43865_P050 SDF1_XENTR motif chemokine 12) (Silurana tropicalis) 93 100.00% Stromal cell‐derived factor 1 (xSDF‐1) (C‐X‐C SLC1A1 ARP43865_P050 SDF1_XENLA motif chemokine 12) Xenopus laevis (African clawed frog) 94 100.00%

ORF Names:GSTENG00024115001 EMBL CAG04406.1OrganismTetraodon nigroviridis (Green puffer) ARP35764_P050 Q6DKA7_XENLA LOC443711 protein (Fragment) Xenopus laevis (African clawed frog) 246 100.00%

ORF Names:GSTENG00024115001 EMBL CAG04406.1OrganismTetraodon nigroviridis (Green puffer) ARP35764_P050 Q52L43_XENLA LOC443711 protein (Fragment) Xenopus laevis (African clawed frog) 231 100.00%

ORF Names:GSTENG00024115001 EMBL CAG04406.1OrganismTetraodon nigroviridis (Green puffer) ARP35764_P050 Q4QR07_XENLA LOC780743 protein (Fragment) Xenopus laevis (African clawed frog) 230 100.00% ORF Names:GSTENG00024115001 EMBL CAG04406.1OrganismTetraodon nigroviridis (Green puffer) ARP35764_P050 Q3KQH4_XENLA MGC130625 protein Xenopus laevis (African clawed frog) 253 100.00%

ORF Names:GSTENG00024115001 EMBL CAG04406.1OrganismTetraodon nigroviridis (Green puffer) ARP35764_P050 Q0P3Q7_XENLA LOC443711 protein Xenopus laevis (African clawed frog) 260 100.00%

ORF Names:GSTENG00024115001 EMBL CAG04406.1OrganismTetraodon Xenopus tropicalis (Western clawed frog) nigroviridis (Green puffer) ARP35764_P050 A0PJP5_XENTR Dlx1 protein (Silurana tropicalis) 251 100.00%

ORF Names:GSTENG00024115001 EMBL CAG04406.1OrganismTetraodon nigroviridis (Green puffer) ARP35764_P050 DLL1_XENLA Homeobox protein DLL‐1 (DLL) (XDLL) Xenopus laevis (African clawed frog) 250 100.00%

ORF Names:GSTENG00024115001 EMBL CAG04406.1OrganismTetraodon nigroviridis (Green puffer) ARP35764_P050 Q6GLJ3_XENLA Dlx5 protein Xenopus laevis (African clawed frog) 286 92.00%

ORF Names:GSTENG00024115001 EMBL CAG04406.1OrganismTetraodon DLL3 (Distal‐less homeo box 5) (Distal‐less Xenopus tropicalis (Western clawed frog) nigroviridis (Green puffer) ARP35764_P050 Q6GLH9_XENTR homeobox 5) (Silurana tropicalis) 289 92.00%

ORF Names:GSTENG00024115001 EMBL CAG04406.1OrganismTetraodon Xenopus tropicalis (Western clawed frog) nigroviridis (Green puffer) ARP35764_P050 Q5BL47_XENTR Distal‐less homeobox 3 (Silurana tropicalis) 276 92.00%

ORF Names:GSTENG00024115001 EMBL CAG04406.1OrganismTetraodon Xenopus tropicalis (Western clawed frog) nigroviridis (Green puffer) ARP35764_P050 Q28BP8_XENTR Distal‐less homeo box 3 (Silurana tropicalis) 277 92.00%

ORF Names:GSTENG00024115001 EMBL CAG04406.1OrganismTetraodon nigroviridis (Green puffer) ARP35764_P050 Q1JQ72_XENLA Putative uncharacterized protein Xenopus laevis (African clawed frog) 274 92.00%

ORF Names:GSTENG00024115001 EMBL CAG04406.1OrganismTetraodon nigroviridis (Green puffer) ARP35764_P050 Q06403_XENLA X‐DLL2 (Fragment) Xenopus laevis (African clawed frog) 266 92.00% ORF Names:GSTENG00024115001 EMBL CAG04406.1OrganismTetraodon nigroviridis (Green puffer) ARP35764_P050 DLL3_XENLA Homeobox protein DLL‐3 (XDLL‐3) Xenopus laevis (African clawed frog) 289 92.00%

ORF Names:GSTENG00024115001 EMBL CAG04406.1OrganismTetraodon nigroviridis (Green puffer) ARP35764_P050 DLL2_XENLA Homeobox protein DLL‐2 (XDLL‐2) Xenopus laevis (African clawed frog) 277 92.00%

ORF Names:GSTENG00024115001 EMBL CAG04406.1OrganismTetraodon nigroviridis (Green puffer) ARP35764_P050 Q6DD47_XENLA MGC80142 protein Xenopus laevis (African clawed frog) 279 85.00%

ORF Names:GSTENG00024115001 EMBL CAG04406.1OrganismTetraodon Xenopus tropicalis (Western clawed frog) nigroviridis (Green puffer) ARP35764_P050 Q66JE3_XENTR Distal‐less homeobox 2 (Silurana tropicalis) 285 85.00% Xenopus tropicalis (Western clawed frog) dpf1 ARP34397_P050 A1L1E9_XENTR Dpf1 protein (Silurana tropicalis) 383 83.00% ARP31638_P050 Q6IRC6_XENLA MGC78787 protein Xenopus laevis (African clawed frog) 526 84.00% E74‐like factor 2 (Ets domain transcription Xenopus tropicalis (Western clawed frog) ARP31638_P050 Q6DIL8_XENTR factor) (Silurana tropicalis) 527 84.00% ARP31638_P050 Q5XHJ7_XENLA MGC78787 protein Xenopus laevis (African clawed frog) 587 84.00% eng2a ARP31375_P050 B7ZQF7_XENLA homolog 2 Xenopus laevis (African clawed frog) 265 84.00%

Homeobox protein engrailed‐2‐A (En‐2A) eng2a ARP31375_P050 HME2A_XENLA (Homeobox protein en‐2‐A) (En2 1.4) Xenopus laevis (African clawed frog) 265 84.00% eng2a ARP31375_P050 B7ZPM7_XENLA En‐2 Xenopus laevis (African clawed frog) 265 76.00%

Homeobox protein engrailed‐2‐B (En‐2B) eng2a ARP31375_P050 HME2B_XENLA (Homeobox protein en‐2‐B) (En2 MABEN) Xenopus laevis (African clawed frog) 265 76.00% Xenopus tropicalis (Western clawed frog) FBXL3 ARP43098_P050 Q28FB0_XENTR F‐box and leucine‐rich repeat protein 3 (Silurana tropicalis) 433 100.00% FBXL3 ARP43098_P050 Q6DCX8_XENLA Fbxl3‐prov protein Xenopus laevis (African clawed frog) 433 92.00% Xenopus tropicalis (Western clawed frog) HHEX ARP31443_P050 B7ZUR5_XENTR Hematopoietically expressed homeobox (Silurana tropicalis) 274 78.00%

Hematopoietically‐expressed homeobox Xenopus tropicalis (Western clawed frog) HHEX ARP31443_P050 HHEX_XENTR protein (Homeobox protein hex) (tHex) (Silurana tropicalis) 274 78.00% Hematopoietically‐expressed homeobox protein hhex (Homeobox protein hex) (XHex) HHEX ARP31443_P050 HHEX_XENLA (Hhex‐A protein) Xenopus laevis (African clawed frog) 272 78.00% Hepatocyte nuclear factor 4‐alpha (HNF‐4‐ alpha) (Nuclear receptor subfamily 2 group A NR2A1 ARP31946_P050 HNF4A_XENLA member 1) Xenopus laevis (African clawed frog) 464 85.00%

ORF Names:DKEY‐33K14.1‐001 EMBL CAM56674.1OrganismDanio rerio Potassium voltage‐gated channel, ‐ Xenopus tropicalis (Western clawed frog) (Zebrafish) (Brachydanio rerio) ARP35126_P050 Q28EG4_XENTR related subfamily, beta member 1 (Silurana tropicalis) 400 76.00% LOC549678 protein (Tropomodulin 3 Xenopus tropicalis (Western clawed frog) tmod ARP55079_P050 Q28ET7_XENTR (Ubiquitous)) (Silurana tropicalis) 344 78.00% Xenopus tropicalis (Western clawed frog) fbxo24 ARP43116_P050 B2GUR8_XENTR LOC100158645 protein (Silurana tropicalis) 573 75.00% Tyrosine 3‐monooxygenase/tryptophan 5‐ monooxygenase activation protein, eta Xenopus tropicalis (Western clawed frog) YWHAH AVARP02061_P050 Q28DR3_XENTR polypeptide (Silurana tropicalis) 247 100.00% YWHAH AVARP02061_P050 Q6DJE2_XENLA MGC84451 protein Xenopus laevis (African clawed frog) 247 93.00% Tyrosine 3‐monooxygenase/tryptophan 5‐ monooxygenase activation protein, gamma Xenopus tropicalis (Western clawed frog) YWHAH AVARP02061_P050 Q0V9W8_XENTR polypeptide (Silurana tropicalis) 247 80.00% YWHAH AVARP02061_P050 143GB_XENLA 14‐3‐3 protein gamma‐B Xenopus laevis (African clawed frog) 247 80.00% YWHAH AVARP02061_P050 143GA_XENLA 14‐3‐3 protein gamma‐A Xenopus laevis (African clawed frog) 247 80.00% Taf13 ARP47596_P050 Q6DKA6_XENLA LOC443712 protein (Fragment) Xenopus laevis (African clawed frog) 123 84.00% Taf13 ARP47596_P050 Q5FWQ5_XENLA MGC84874 protein Xenopus laevis (African clawed frog) 124 84.00%

TAF13 RNA polymerase II, TATA box binding Xenopus tropicalis (Western clawed frog) Taf13 ARP47596_P050 Q28EZ3_XENTR protein (TBP)‐associated factor, 18kDa (Silurana tropicalis) 124 84.00% Taf13 ARP47596_P050 A4FVD6_XENLA LOC443712 protein Xenopus laevis (African clawed frog) 124 84.00% Xenopus tropicalis (Western clawed frog) P100674_P050 B5DFP8_XENTR Hsp90aa1.1 protein (Silurana tropicalis) 702 75.00% Xenopus tropicalis (Western clawed frog) P100674_P050 B1H124_XENTR Putative uncharacterized protein (Fragment) (Silurana tropicalis) 273 75.00% ZBTB44 ARP35875_P050 Q6NRN2_XENLA MGC83473 protein Xenopus laevis (African clawed frog) 398 76.00% Zinc finger and BTB domain‐containing protein Xenopus tropicalis (Western clawed frog) ZBTB44 ARP35875_P050 ZBT44_XENTR 44 (Silurana tropicalis) 448 76.00% Xenopus tropicalis (Western clawed frog) Rnf39 ARP40084_P050 B4F6Z8_XENTR Putative uncharacterized protein (Silurana tropicalis) 461 84.00% Xenopus tropicalis (Western clawed frog) Rnf39 ARP40084_P050 B2GUH4_XENTR Putative uncharacterized protein (Silurana tropicalis) 648 84.00% Xenopus tropicalis (Western clawed frog) Rnf39 ARP40084_P050 B1WBK6_XENTR Putative uncharacterized protein (Fragment) (Silurana tropicalis) 536 84.00% Xenopus tropicalis (Western clawed frog) Rnf39 ARP40084_P050 B0BMK3_XENTR Putative uncharacterized protein (Silurana tropicalis) 608 84.00% Xenopus tropicalis (Western clawed frog) Rnf39 ARP40084_P050 A4II77_XENTR Ppp2r3a protein (Silurana tropicalis) 574 84.00% Rnf39 ARP40084_P050 A9JS19_XENLA Xnf7 protein Xenopus laevis (African clawed frog) 609 84.00% Rnf39 ARP40084_P050 A3KMT7_XENLA Xnf7 protein (Fragment) Xenopus laevis (African clawed frog) 588 84.00% Rnf39 ARP40084_P050 NF7O_XENLA Isoform 2 Xenopus laevis (African clawed frog) 553 84.00% Rnf39 ARP40084_P050 NF7O_XENLA Nuclear factor 7, ovary (xNF7‐O) Xenopus laevis (African clawed frog) 610 84.00% Rnf39 ARP40084_P050 NF7B_XENLA Nuclear factor 7, brain (xNF7) (xNF7‐B) Xenopus laevis (African clawed frog) 609 84.00% LOC733841 protein (Novel protein containing Xenopus tropicalis (Western clawed frog) Rnf39 ARP40084_P050 Q28DV0_XENTR SPRY domain) (Silurana tropicalis) 331 90.00% ORF Names:PANDA_013806 EMBL EFB18683.1OrganismAiluropoda Xenopus tropicalis (Western clawed frog) melanoleuca (Giant panda) ARP32468_P050 Q66KL2_XENTR C‐terminal binding protein 1 (Silurana tropicalis) 440 92.00% ORF Names:PANDA_013806 EMBL EFB18683.1OrganismAiluropoda melanoleuca (Giant panda) ARP32468_P050 Q5XHH5_XENLA LOC494997 protein Xenopus laevis (African clawed frog) 430 92.00% ORF Names:PANDA_013806 EMBL EFB18683.1OrganismAiluropoda C‐terminal‐binding protein 1 (CtBP1) (EC 1.1.1.‐ melanoleuca (Giant panda) ARP32468_P050 CTBP1_XENLA ) (C‐terminal‐binding protein A) Xenopus laevis (African clawed frog) 440 85.00% dach2 ARP32425_P050 Q5PQ18_XENLA LOC496011 protein Xenopus laevis (African clawed frog) 610 100.00% Xenopus tropicalis (Western clawed frog) dach2 ARP32425_P050 A8E4U6_XENTR Dach2 protein (Silurana tropicalis) 592 100.00% dach2 ARP32425_P050 Q0PNF8_XENLA Dachshund 1 Xenopus laevis (African clawed frog) 749 76.00% Xenopus tropicalis (Western clawed frog) dach2 ARP32425_P050 Q0PNF7_XENTR Dachshund 1 (Silurana tropicalis) 692 76.00% dach2 ARP32425_P050 B7ZRN2_XENLA Putative uncharacterized protein Xenopus laevis (African clawed frog) 696 76.00% Xenopus tropicalis (Western clawed frog) P100638_P050 Q28DU7_XENTR Ets variant gene 6 (TEL oncogene) (Silurana tropicalis) 450 92.00% Xenopus tropicalis (Western clawed frog) etv6 P100638_P050 Q0IHQ4_XENTR Ets variant 6 (Silurana tropicalis) 450 92.00% etv6 P100638_P050 B3VKU4_XENLA Ets variant 6 Xenopus laevis (African clawed frog) 448 92.00% Catenin (Cadherin associated protein), beta 1, 88kDa (Catenin (Cadherin‐associated protein), Xenopus tropicalis (Western clawed frog) CTNNB P100601_P050 Q28GC2_XENTR beta 1, 88kDa) (Silurana tropicalis) 781 100.00% CTNNB P100601_P050 Q7ZX35_XENLA Ctnnb1‐prov protein Xenopus laevis (African clawed frog) 781 92.00% CTNNB P100601_P050 A1A5I6_XENLA Ctnnb1 protein Xenopus laevis (African clawed frog) 780 92.00% CTNNB P100601_P050 Q63ZT4_XENLA Beta‐catenin protein Xenopus laevis (African clawed frog) 781 92.00% CTNNB P100601_P050 CTNB_XENLA Catenin beta (Beta‐catenin) Xenopus laevis (African clawed frog) 781 92.00% Xenopus tropicalis (Western clawed frog) tsr1 ARP46270_P050 B1WBH9_XENTR Tsr1 protein (Fragment) (Silurana tropicalis) 747 92.00% tsr1 ARP46270_P050 TSR1_XENLA Pre‐rRNA‐processing protein TSR1 homolog Xenopus laevis (African clawed frog) 815 92.00% Xenopus tropicalis (Western clawed frog) tbx20 ARP33177_P050 B7ZSN5_XENTR T‐box 20 (Silurana tropicalis) 440 100.00% tbx20 ARP33177_P050 B7ZQT9_XENLA T‐box 20 Xenopus laevis (African clawed frog) 441 100.00% T‐box transcription factor TBX20 (T‐box Xenopus tropicalis (Western clawed frog) tbx20 ARP33177_P050 TBX20_XENTR protein 20) (Silurana tropicalis) 440 100.00% T‐box transcription factor TBX20 (T‐box tbx20 ARP33177_P050 TBX20_XENLA protein 20) Xenopus laevis (African clawed frog) 441 100.00%

Ubiquitin carboxyl‐terminal hydrolase 22‐B (EC 3.4.19.12) (Deubiquitinating 22‐B) (Ubiquitin thiolesterase 22‐B) (Ubiquitin‐ usp22 ARP58352_P050 UB22B_XENLA specific‐processing protease 22‐B) Xenopus laevis (African clawed frog) 523 92.00%

Ubiquitin carboxyl‐terminal hydrolase 22‐A (EC 3.4.19.12) (Deubiquitinating enzyme 22‐A) (Ubiquitin thiolesterase 22‐A) (Ubiquitin‐ usp22 ARP58352_P050 UB22A_XENLA specific‐processing protease 22‐A) Xenopus laevis (African clawed frog) 523 92.00% Xenopus tropicalis (Western clawed frog) thrab ARP34780_P050 Q0EDH8_XENTR Thyroid alpha (Silurana tropicalis) 418 85.00% Xenopus tropicalis (Western clawed frog) thrab ARP34780_P050 Q0EDH7_XENTR beta (Silurana tropicalis) 383 92.00% Xenopus tropicalis (Western clawed frog) thrab ARP34780_P050 B3GR08_XENTR Thyroid hormone receptor beta (Silurana tropicalis) 383 92.00% Xenopus tropicalis (Western clawed frog) thrab ARP34780_P050 B3GR07_XENTR Thyroid hormone receptor alpha (Silurana tropicalis) 418 85.00% thrab ARP34780_P050 THBB_XENLA Isoform Beta‐B1 (Isoform BetaB‐I) Xenopus laevis (African clawed frog) 374 92.00% thrab ARP34780_P050 THBA_XENLA Isoform Beta‐A1 (Isoform BetaA‐I) Xenopus laevis (African clawed frog) 369 92.00% Thyroid hormone receptor beta‐B (TRbetaB) (Nuclear receptor subfamily 1 group A thrab ARP34780_P050 THBB_XENLA member 2‐B) Xenopus laevis (African clawed frog) 414 92.00% Thyroid hormone receptor beta‐A (TRbetaA) (xTR) (Nuclear receptor subfamily 1 group A thrab ARP34780_P050 THBA_XENLA member 2‐A) Xenopus laevis (African clawed frog) 373 92.00% Thyroid hormone receptor alpha‐B (TRalphaB) (Nuclear receptor subfamily 1 group A thrab ARP34780_P050 THAB_XENLA member 1‐B) Xenopus laevis (African clawed frog) 418 85.00%

Thyroid hormone receptor alpha‐A (TRalphaA) (XenTR‐alpha1) (Nuclear receptor subfamily 1 thrab ARP34780_P050 THAA_XENLA group A member 1‐A) Xenopus laevis (African clawed frog) 418 85.00%

Tyrosyl‐DNA phosphodiesterase 2 (Tyr‐DNA phosphodiesterase 2) (EC 3.1.4.‐) (5'‐tyrosyl‐ DNA phosphodiesterase) (5'‐Tyr‐DNA phosphodiesterase) (TRAF and TNF receptor‐ Xenopus tropicalis (Western clawed frog) pdcd8 ARP33010_P050 TYDP2_XENTR associated protein homolog) (Silurana tropicalis) 373 85.00% Tyrosyl‐DNA phosphodiesterase 2 (Tyr‐DNA phosphodiesterase 2) (EC 3.1.4.‐) (5'‐tyrosyl‐ DNA phosphodiesterase) (5'‐Tyr‐DNA phosphodiesterase) (TRAF and TNF receptor‐ pdcd8 ARP33010_P050 TYDP2_XENLA associated protein homolog) Xenopus laevis (African clawed frog) 371 85.00% 8 (‐inducing Xenopus tropicalis (Western clawed frog) pdcd8 ARP33010_P050 Q28IZ0_XENTR factor) (Silurana tropicalis) 636 92.00% Programmed cell death 8 (Apoptosis‐inducing Xenopus tropicalis (Western clawed frog) AVARP02013_P050 Q28IZ0_XENTR factor) (Silurana tropicalis) 636 92.00% Xenopus tropicalis (Western clawed frog) STX1A AVARP13091_P050 Q0VFR6_XENTR 1A (Brain) (Silurana tropicalis) 288 78.00% ARP34182_P050 Q9I8J5_XENLA Csrp3‐A‐prov protein (LIM protein) Xenopus laevis (African clawed frog) 194 85.00% Xenopus tropicalis (Western clawed frog) csrp3 ARP34182_P050 Q6DF32_XENTR Cysteine and glycine‐rich protein 2 (Silurana tropicalis) 194 85.00% Xenopus tropicalis (Western clawed frog) EWSR1 ARP38594_P050 Q6P3N0_XENTR Putative uncharacterized protein MGC76258 (Silurana tropicalis) 674 85.00% Xenopus tropicalis (Western clawed frog) EWSR1 ARP38594_P050 Q6DJQ4_XENTR Putative uncharacterized protein MGC76258 (Silurana tropicalis) 673 85.00% EWSR1 ARP38594_P050 Q2VPG6_XENLA Putative uncharacterized protein Xenopus laevis (African clawed frog) 671 85.00% EWSR1 ARP38594_P050 Q4QR27_XENLA LOC733270 protein (Fragment) Xenopus laevis (African clawed frog) 666 78.00% EWSR1 ARP38594_P050 Q2VPI2_XENLA MGC132026 protein Xenopus laevis (African clawed frog) 667 78.00% Xenopus tropicalis (Western clawed frog) st8sia4 ARP48679_P050 A1KQY5_XENTR Alpha 2,8‐sialyltransferase ST8Sia VI (Silurana tropicalis) 359 100.00% Xenopus tropicalis (Western clawed frog) pcgf3 ARP34416_P050 B5DET4_XENTR Polycomb group ring finger 3 (Silurana tropicalis) 242 76.00% Xenopus tropicalis (Western clawed frog) pcgf3 ARP34416_P050 PCGF3_XENTR Polycomb group RING finger protein 3 (Silurana tropicalis) 242 76.00% Xenopus tropicalis (Western clawed frog) pou6f1 ARP31433_P050 A8E4V1_XENTR Pou6f1 protein (Silurana tropicalis) 478 100.00% ARP48202_P050 Q7SYT0_XENLA Eef1a2‐prov protein Xenopus laevis (African clawed frog) 463 100.00% Eukaryotic translation elongation factor 1 Xenopus tropicalis (Western clawed frog) ARP48202_P050 Q5I0S9_XENTR alpha 2 (Silurana tropicalis) 463 100.00% Xenopus tropicalis (Western clawed frog) ARP48202_P050 B1H2D7_XENTR LOC100145396 protein (Silurana tropicalis) 462 92.00% Eukaryotic translation elongation factor 1 Xenopus tropicalis (Western clawed frog) ARP48202_P050 A9UMS0_XENTR alpha 1 (Silurana tropicalis) 462 92.00% Elongation factor 1‐alpha, somatic form (EF‐1‐ ARP48202_P050 EF1A0_XENLA alpha‐S) Xenopus laevis (African clawed frog) 462 92.00% ARP48202_P050 Q7ZXA2_XENLA Eef1a‐o1 protein Xenopus laevis (African clawed frog) 461 85.00% Eukaryotic translation elongation factor 1 alpha 1 (Eukaryotic translation elongation Xenopus tropicalis (Western clawed frog) ARP48202_P050 Q6P356_XENTR factor 1 alpha 1, oocyte form) (Silurana tropicalis) 461 85.00% Prps2 ARP41447_P050 Q7ZXR6_XENLA Prps1 protein (Fragment) Xenopus laevis (African clawed frog) 326 85.00% Similar to phosphoribosyl pyrophosphate Xenopus tropicalis (Western clawed frog) Prps2 ARP41447_P050 Q6P830_XENTR synthetase 1 (Silurana tropicalis) 318 85.00% Prps2 ARP41447_P050 Q6AZI9_XENLA Prps1 protein Xenopus laevis (African clawed frog) 318 85.00% Ribose‐phosphate pyrophosphokinase 2 (EC 2.7.6.1) (Phosphoribosyl pyrophosphate Xenopus tropicalis (Western clawed frog) Prps2 ARP41447_P050 PRPS2_XENTR synthase II) (PRS‐II) (Silurana tropicalis) 318 85.00% Ribose‐phosphate pyrophosphokinase 2 (EC 2.7.6.1) (Phosphoribosyl pyrophosphate Prps2 ARP41447_P050 PRPS2_XENLA synthase II) (PRS‐II) Xenopus laevis (African clawed frog) 318 85.00% Xenopus tropicalis (Western clawed frog) ikzf5 ARP33276_P050 IKZF5_XENTR Isoform 2 (Silurana tropicalis) 441 92.00% Zinc finger protein Pegasus (Ikaros family zinc Xenopus tropicalis (Western clawed frog) ikzf5 ARP33276_P050 IKZF5_XENTR finger protein 5) (Silurana tropicalis) 434 92.00% Zinc finger protein Pegasus (Ikaros family zinc ikzf5 ARP33276_P050 IKZF5_XENLA finger protein 5) Xenopus laevis (African clawed frog) 453 92.00% Ionotropic glutamate receptor subunit gria3a ARP35341_P050 B9V8S1_XENLA GluR6(Q) Xenopus laevis (African clawed frog) 908 100.00% Glutamate receptor, ionotropic kainate 2 (Glutamate receptor 6) (GluR‐6) (GluR6) gria3a ARP35341_P050 GRIK2_XENLA (Fragment) Xenopus laevis (African clawed frog) 285 100.00% Ionotropic glutamate receptor subunit GluR7 gria3a ARP35341_P050 B9V8R0_XENLA (Fragment) Xenopus laevis (African clawed frog) 162 92.00% Ionotropic glutamate receptor subunit gria3a ARP35341_P050 B9V8R7_XENLA GluR1(Q)flip Xenopus laevis (African clawed frog) 902 92.00% Xenopus tropicalis (Western clawed frog) gria3a ARP35341_P050 A8E4U5_XENTR LOC100127569 protein (Fragment) (Silurana tropicalis) 780 92.00% Ionotropic glutamate receptor subunit gria3a ARP35341_P050 B9V8S0_XENLA GluR4(Q)flop Xenopus laevis (African clawed frog) 902 84.00% Ionotropic glutamate receptor subunit gria3a ARP35341_P050 B9V8R9_XENLA GluR3(Q)flop Xenopus laevis (African clawed frog) 887 84.00% Xenopus tropicalis (Western clawed frog) gria3a ARP35341_P050 A8WGF6_XENTR LOC100127683 protein (Silurana tropicalis) 887 84.00% Ionotropic glutamate receptor subunit gria3a ARP35341_P050 B9V8R8_XENLA GluR2(R)flop Xenopus laevis (African clawed frog) 882 76.00% Xenopus tropicalis (Western clawed frog) gria3a ARP35341_P050 B4F6U0_XENTR Putative uncharacterized protein (Silurana tropicalis) 767 76.00% Xenopus tropicalis (Western clawed frog) ATG8 ARP51265_P050 Q5PPQ1_XENTR GABA(A) receptor‐associated protein like 1 (Silurana tropicalis) 117 100.00% ATG8 ARP51265_P050 Q6NUG7_XENLA MGC78908 protein Xenopus laevis (African clawed frog) 117 92.00%

ORF Names:39079OrganismMonosiga ATP‐dependent RNA helicase DDX1 (EC Xenopus tropicalis (Western clawed frog) brevicollis (Choanoflagellate) ARP36379_P050 DDX1_XENTR 3.6.4.13) (DEAD box protein 1) (Silurana tropicalis) 740 84.00% ORF Names:39079OrganismMonosiga ATP‐dependent RNA helicase DDX1 (EC brevicollis (Choanoflagellate) ARP36379_P050 DDX1_XENLA 3.6.4.13) (DEAD box protein 1) Xenopus laevis (African clawed frog) 740 84.00% Xenopus tropicalis (Western clawed frog) ARP58157_P050 Q6P7M9_XENTR High‐mobility group box 2 (Silurana tropicalis) 212 86.00% ARP58157_P050 Q91764_XENLA HMG‐X protein Xenopus laevis (African clawed frog) 212 80.00% ARP58157_P050 Q8AVU3_XENLA MGC52825 protein Xenopus laevis (African clawed frog) 212 80.00% ARP58157_P050 Q7ZXK5_XENLA MGC52578 protein Xenopus laevis (African clawed frog) 212 80.00% ARP58157_P050 Q32NS7_XENLA MGC52825 protein Xenopus laevis (African clawed frog) 211 80.00% ARP34340_P050 Q68FK7_XENLA MGC81942 protein Xenopus laevis (African clawed frog) 469 100.00% Xenopus tropicalis (Western clawed frog) ARP34340_P050 Q0VFL6_XENTR RUN and FYVE domain containing 3 (Silurana tropicalis) 469 100.00% Xenopus tropicalis (Western clawed frog) ARP33681_P050 Q6DIF2_XENTR Ubiquitin specific peptidase 3 (Silurana tropicalis) 467 92.00% Xenopus tropicalis (Western clawed frog) ARP33681_P050 Q28F28_XENTR Ubiquitin specific protease 3 (Silurana tropicalis) 522 92.00% ARP33681_P050 A0JMV8_XENLA LOC100036785 protein Xenopus laevis (African clawed frog) 522 92.00% TAF9 ARP34551_P050 Q6AZI6_XENLA MGC80885 protein Xenopus laevis (African clawed frog) 171 78.00% TAF9 ARP34551_P050 Q4QQY8_XENLA MGC115514 protein Xenopus laevis (African clawed frog) 171 78.00% Xenopus tropicalis (Western clawed frog) TAF9 ARP34551_P050 Q28HQ4_XENTR OTTXETP00000007949 (Silurana tropicalis) 171 78.00% Hsph1 ARP46074_P050 Q6DE62_XENLA LOC398863 protein Xenopus laevis (African clawed frog) 836 85.00% Xenopus tropicalis (Western clawed frog) Hsph1 ARP46074_P050 Q6P3M8_XENTR Osmotic stress protein 94 kDa (Silurana tropicalis) 835 78.00% Hsph1 ARP46074_P050 Q6GPQ2_XENLA MGC82693 protein Xenopus laevis (African clawed frog) 854 76.00% Hsph1 ARP46074_P050 Q6DE28_XENLA Hsp105‐prov protein Xenopus laevis (African clawed frog) 852 76.00% Hsph1 ARP46074_P050 Q1PAH4_XENLA 110 Xenopus laevis (African clawed frog) 854 76.00% ORF Names:PANDA_006063 EMBL EFB14097.1OrganismAiluropoda melanoleuca (Giant panda) ARP48741_P050 Q6NU67_XENLA MGC81201 protein Xenopus laevis (African clawed frog) 356 92.00% ORF Names:PANDA_006063 EMBL EFB14097.1OrganismAiluropoda Xenopus tropicalis (Western clawed frog) melanoleuca (Giant panda) ARP48741_P050 B1H370_XENTR LOC100145562 protein (Silurana tropicalis) 356 92.00% ORF Names:PANDA_006063 EMBL EFB14097.1OrganismAiluropoda Heparan sulfate 2‐O‐sulfotransferase 1 (EC melanoleuca (Giant panda) ARP48741_P050 HS2ST_XENLA 2.8.2.‐) Xenopus laevis (African clawed frog) 356 92.00% Xenopus tropicalis (Western clawed frog) Zfp318 ARP32523_P050 B1H2S7_XENTR Kremen1 protein (Silurana tropicalis) 339 91.00% Kremen protein 1 (Dickkopf receptor) (Kringle‐ containing protein marking the eye and the Zfp318 ARP32523_P050 KREM1_XENLA nose) Xenopus laevis (African clawed frog) 452 91.00% Xenopus tropicalis (Western clawed frog) Kremen1 ARP44880_P050 B1H2S7_XENTR Kremen1 protein (Silurana tropicalis) 339 91.00% Kremen protein 1 (Dickkopf receptor) (Kringle‐ containing protein marking the eye and the Kremen1 ARP44880_P050 KREM1_XENLA nose) Xenopus laevis (African clawed frog) 452 91.00% GTF2A1 ARP58154_P050 Q5HZB8_XENLA Putative uncharacterized protein Xenopus laevis (African clawed frog) 369 85.00% GTF2A1 ARP58154_P050 B7ZS19_XENLA Putative uncharacterized protein Xenopus laevis (African clawed frog) 367 85.00% TFIIAa/b‐2 protein (Transcription factor IIA GTF2A1 ARP58154_P050 Q6XPY4_XENLA large subunit‐2) Xenopus laevis (African clawed frog) 367 78.00% GTF2A1 ARP58154_P050 Q6ING6_XENLA TFIIAa/b‐2 protein (Fragment) Xenopus laevis (African clawed frog) 366 78.00% Xenopus tropicalis (Western clawed frog) GTF2A1 ARP58154_P050 Q28E35_XENTR General transcription factor IIA, 1 (Silurana tropicalis) 367 78.00% GTF2A1 ARP58154_P050 Q71N44_XENLA Transcription factor IIA large subunit Xenopus laevis (African clawed frog) 370 78.00% GTF2A1 ARP58154_P050 Q6XPY2_XENLA Transcription factor IIA large subunit‐1 Xenopus laevis (African clawed frog) 370 78.00% ORF Names:SIAM614_15470 EMBL EAV44211.1OrganismLabrenzia aggregata IAM 12614 ARP41219_P050 Q91708_XENLA C4SR protein Xenopus laevis (African clawed frog) 337 78.00% Xenopus tropicalis (Western clawed frog) kcnh5a ARP35478_P050 B2GU68_XENTR Kcnh5 protein (Silurana tropicalis) 985 100.00% ARP54862_P050 Q6GPU2_XENLA MGC82611 protein Xenopus laevis (African clawed frog) 318 100.00% ARP54862_P050 Q6GLN0_XENLA MGC84680 protein Xenopus laevis (African clawed frog) 318 100.00% Xenopus tropicalis (Western clawed frog) ARP54862_P050 B1H1F3_XENTR LOC100145349 protein (Silurana tropicalis) 316 100.00% Kcnip2 ARP35488_P050 Q4V7N5_XENLA MGC115522 protein Xenopus laevis (African clawed frog) 233 83.00% Xenopus tropicalis (Western clawed frog) Rgs9 AVARP09004_P050 A4QNA1_XENTR LOC100125123 protein (Silurana tropicalis) 469 91.00% Rgs9 AVARP09004_P050 Q6GP01_XENLA MGC80762 protein Xenopus laevis (African clawed frog) 236 91.00%

Rgs9 AVARP09004_P050 Q6DCK4_XENLA Putative uncharacterized protein (Fragment) Xenopus laevis (African clawed frog) 192 91.00% Xenopus tropicalis (Western clawed frog) Rgs9 AVARP09004_P050 Q66IM3_XENTR Rgs18 protein (Silurana tropicalis) 235 91.00% Xenopus tropicalis (Western clawed frog) Rgs9 AVARP09004_P050 B3DM78_XENTR LOC100170622 protein (Silurana tropicalis) 187 91.00% Rgs9 AVARP09004_P050 Q66KY2_XENLA MGC85328 protein Xenopus laevis (African clawed frog) 128 83.00% Xenopus tropicalis (Western clawed frog) rgs1 ARP35456_P050 RGS1_XENTR Regulator of G‐protein signaling 1 (RGS1) (Silurana tropicalis) 201 83.00% rgs1 ARP35456_P050 RGS1_XENLA Regulator of G‐protein signaling 1 (RGS1) Xenopus laevis (African clawed frog) 201 83.00% rgs1 ARP35456_P050 Q9I9D9_XENLA RGS4 protein (Rgs4‐A protein) Xenopus laevis (African clawed frog) 204 83.00% Regulator of G‐protein signaling 4 (Regulator Xenopus tropicalis (Western clawed frog) rgs1 ARP35456_P050 Q6P300_XENTR of G‐protein signalling 4) (Silurana tropicalis) 205 83.00% rgs1 ARP35456_P050 Q5U501_XENLA Putative uncharacterized protein Xenopus laevis (African clawed frog) 206 83.00% Xenopus tropicalis (Western clawed frog) Rgs9 AVARP09004_P050 RGS1_XENTR Regulator of G‐protein signaling 1 (RGS1) (Silurana tropicalis) 201 83.00% Rgs9 AVARP09004_P050 RGS1_XENLA Regulator of G‐protein signaling 1 (RGS1) Xenopus laevis (African clawed frog) 201 83.00% rgs1 ARP35456_P050 Q4V7I3_XENLA MGC115680 protein Xenopus laevis (African clawed frog) 331 75.00% Rgs9 AVARP09004_P050 Q9I9D9_XENLA RGS4 protein (Rgs4‐A protein) Xenopus laevis (African clawed frog) 204 83.00% Regulator of G‐protein signaling 4 (Regulator Xenopus tropicalis (Western clawed frog) Rgs9 AVARP09004_P050 Q6P300_XENTR of G‐protein signalling 4) (Silurana tropicalis) 205 83.00% Rgs9 AVARP09004_P050 Q5U501_XENLA Putative uncharacterized protein Xenopus laevis (African clawed frog) 206 83.00% Rgs9 AVARP09004_P050 Q4V7I3_XENLA MGC115680 protein Xenopus laevis (African clawed frog) 331 75.00% ARP35263_P050 Q7T0U3_XENLA Clic5‐prov protein Xenopus laevis (African clawed frog) 250 92.00% Xenopus tropicalis (Western clawed frog) clic5 ARP35263_P050 Q6DF44_XENTR Chloride intracellular channel 4 (Silurana tropicalis) 250 92.00% clic5 ARP35263_P050 Q6DFA4_XENLA MGC83873 protein Xenopus laevis (African clawed frog) 252 92.00% Xenopus tropicalis (Western clawed frog) clic5 ARP35263_P050 Q66KL1_XENTR Chloride intracellular channel 4 (Silurana tropicalis) 252 92.00% Chloride intracellular channel protein 4 clic5 ARP35263_P050 B2L439_XENBO (Fragment) Xenopus borealis (Kenyan clawed frog) 24 92.00% clic5 ARP35263_P050 Q7T249_XENLA Chloride intracellular channel protein 4 Xenopus laevis (African clawed frog) 252 84.00% clic5 ARP35263_P050 Q6GQF7_XENLA CLIC4 protein Xenopus laevis (African clawed frog) 252 84.00% frRunxb P100598_P050 Q6AZI5_XENLA MGC80899 protein Xenopus laevis (African clawed frog) 174 85.00% Gastrula zinc finger protein XlCGF66.1 ARP58189_P050 ZG66_XENLA (Fragment) Xenopus laevis (African clawed frog) 606 90.00% 3‐hydroxyacyl‐CoA dehydratase (HACD) (EC 4.2.1.‐) (Protein tyrosine phosphatase‐like protein ptplad2) (Protein‐tyrosine phosphatase‐like A domain‐containing protein Ptplad2 ARP44598_P050 HACD_XENLA 2) Xenopus laevis (African clawed frog) 218 92.00% AVARP03036_P050 Q6PCF2_XENLA MGC69167 protein Xenopus laevis (African clawed frog) 745 100.00% ORF Names:GSPATT00004654001 EMBL CAK58282.1OrganismParamecium tetraurelia ARP58011_P050 Q8AVM8_XENLA Ube2k protein Xenopus laevis (African clawed frog) 200 100.00% ORF Names:GSPATT00004654001 EMBL CAK58282.1OrganismParamecium Ubiquitin‐conjugating enzyme E2K (UBC1 Xenopus tropicalis (Western clawed frog) tetraurelia ARP58011_P050 Q6GL28_XENTR homolog) (Silurana tropicalis) 200 100.00% ORF Names:GSPATT00004654001 EMBL CAK58282.1OrganismParamecium Xenopus tropicalis (Western clawed frog) tetraurelia ARP58011_P050 B0JZQ9_XENTR LOC100145219 protein (Silurana tropicalis) 200 100.00% SWI/SNF‐related matrix‐associated actin‐ dependent regulator of subfamily B Xenopus tropicalis (Western clawed frog) ARP34171_P050 SNF5_XENTR member 1 (Silurana tropicalis) 378 100.00% SWI/SNF‐related matrix‐associated actin‐ dependent regulator of chromatin subfamily B ARP34171_P050 SNF5_XENLA member 1 Xenopus laevis (African clawed frog) 378 100.00% DDAH2 ARP54851_P050 Q7T0R4_XENLA Ddah1‐prov protein Xenopus laevis (African clawed frog) 284 100.00% Xenopus tropicalis (Western clawed frog) DDAH2 ARP54851_P050 Q08BT8_XENTR LOC100145661 protein (Silurana tropicalis) 284 100.00% ORF Names:GSPATT00013765001 EMBL Ubiquitin‐conjugating enzyme E2D 2 (UBC4/5 CAK78335.1OrganismParamecium homolog, ) (Ubiquitin‐conjugating Xenopus tropicalis (Western clawed frog) tetraurelia ARP43007_P050 Q28EY6_XENTR enzyme E2D 3 (UBC4/5 homolog)) (Silurana tropicalis) 147 100.00% ORF Names:GSPATT00013765001 Ubiquitin‐conjugating enzyme E2 D2 (EC EMBL 6.3.2.19) (Ubiquitin carrier protein 4) (xUBC4) CAK78335.1OrganismParamecium (Ubiquitin carrier protein D2) (Ubiquitin‐ tetraurelia ARP43007_P050 UB2D2_XENLA protein ligase D2) Xenopus laevis (African clawed frog) 147 100.00% ORF Names:GSPATT00013765001 EMBL CAK78335.1OrganismParamecium tetraurelia ARP43007_P050 Q6DFK8_XENLA LOC495381 protein (Ube2d2‐prov protein) Xenopus laevis (African clawed frog) 147 85.00% ORF Names:GSPATT00013765001 EMBL CAK78335.1OrganismParamecium Ubiquitin‐conjugating enzyme E2D 1 (UBC4/5 Xenopus tropicalis (Western clawed frog) tetraurelia ARP43007_P050 A0JM78_XENTR homolog) (Silurana tropicalis) 147 85.00% ORF Names:GSPATT00013765001 EMBL Ubiquitin‐conjugating enzyme E2 D4 (EC CAK78335.1OrganismParamecium 6.3.2.19) (Ubiquitin carrier protein D4) tetraurelia ARP43007_P050 UB2D4_XENLA (Ubiquitin‐protein ligase D4) Xenopus laevis (African clawed frog) 147 78.00% Xenopus tropicalis (Western clawed frog) GATAD1 ARP33193_P050 B1H2T9_XENTR Putative uncharacterized protein (Silurana tropicalis) 268 92.00%

GATAD1 ARP33193_P050 GATD1_XENLA GATA zinc finger domain‐containing protein 1 Xenopus laevis (African clawed frog) 245 92.00% DDAH1 ARP54852_P050 Q7T0R4_XENLA Ddah1‐prov protein Xenopus laevis (African clawed frog) 284 100.00% Xenopus tropicalis (Western clawed frog) DDAH1 ARP54852_P050 Q08BT8_XENTR LOC100145661 protein (Silurana tropicalis) 284 100.00%

Ubiquitin carboxyl‐terminal hydrolase 22‐B ORF Names:PANDA_019055 EMBL (EC 3.4.19.12) (Deubiquitinating enzyme 22‐B) EFB21925.1OrganismAiluropoda (Ubiquitin thiolesterase 22‐B) (Ubiquitin‐ melanoleuca (Giant panda) ARP58353_P050 UB22B_XENLA specific‐processing protease 22‐B) Xenopus laevis (African clawed frog) 523 100.00%

Ubiquitin carboxyl‐terminal hydrolase 22‐A ORF Names:PANDA_019055 EMBL (EC 3.4.19.12) (Deubiquitinating enzyme 22‐A) EFB21925.1OrganismAiluropoda (Ubiquitin thiolesterase 22‐A) (Ubiquitin‐ melanoleuca (Giant panda) ARP58353_P050 UB22A_XENLA specific‐processing protease 22‐A) Xenopus laevis (African clawed frog) 523 100.00% Xenopus tropicalis (Western clawed frog) Znf382 ARP33514_P050 Q0V9Z4_XENTR Putative uncharacterized protein MGC145688 (Silurana tropicalis) 594 84.00% ORF Names:GSPATT00033513001 EMBL CAK63660.1OrganismParamecium tetraurelia ARP48740_P050 Q6NU67_XENLA MGC81201 protein Xenopus laevis (African clawed frog) 356 92.00% ORF Names:GSPATT00033513001 EMBL CAK63660.1OrganismParamecium Xenopus tropicalis (Western clawed frog) tetraurelia ARP48740_P050 B1H370_XENTR LOC100145562 protein (Silurana tropicalis) 356 100.00% ORF Names:GSPATT00033513001 EMBL CAK63660.1OrganismParamecium Heparan sulfate 2‐O‐sulfotransferase 1 (EC tetraurelia ARP48740_P050 HS2ST_XENLA 2.8.2.‐) Xenopus laevis (African clawed frog) 356 92.00% ORF Names:GSPATT00000658001 EMBL CAK70947.1, GSPATT00032377001 EMBL CAK62145.1OrganismParamecium tetraurelia ARP43010_P050 Q6DFK8_XENLA LOC495381 protein (Ube2d2‐prov protein) Xenopus laevis (African clawed frog) 147 100.00% ORF Names:GSPATT00000658001 EMBL CAK70947.1, GSPATT00032377001 EMBL Ubiquitin‐conjugating enzyme E2D 2 (UBC4/5 CAK62145.1OrganismParamecium homolog, yeast) (Ubiquitin‐conjugating Xenopus tropicalis (Western clawed frog) tetraurelia ARP43010_P050 Q28EY6_XENTR enzyme E2D 3 (UBC4/5 homolog)) (Silurana tropicalis) 147 100.00% ORF Names:GSPATT00000658001 EMBL CAK70947.1, GSPATT00032377001 EMBL CAK62145.1OrganismParamecium Xenopus tropicalis (Western clawed frog) tetraurelia ARP43010_P050 B0JYU2_XENTR Putative uncharacterized protein (Fragment) (Silurana tropicalis) 136 100.00% ORF Names:GSPATT00000658001 EMBL CAK70947.1, GSPATT00032377001 EMBL CAK62145.1OrganismParamecium Ubiquitin‐conjugating enzyme E2D 1 (UBC4/5 Xenopus tropicalis (Western clawed frog) tetraurelia ARP43010_P050 A0JM78_XENTR homolog) (Silurana tropicalis) 147 100.00% ORF Names:GSPATT00000658001 EMBL CAK70947.1, GSPATT00032377001 EMBL Ubiquitin‐conjugating enzyme E2 D4 (EC CAK62145.1OrganismParamecium 6.3.2.19) (Ubiquitin carrier protein D4) tetraurelia ARP43010_P050 UB2D4_XENLA (Ubiquitin‐protein ligase D4) Xenopus laevis (African clawed frog) 147 100.00% ORF Names:GSPATT00000658001 EMBL CAK70947.1, Ubiquitin‐conjugating enzyme E2 D2 (EC GSPATT00032377001 EMBL 6.3.2.19) (Ubiquitin carrier protein 4) (xUBC4) CAK62145.1OrganismParamecium (Ubiquitin carrier protein D2) (Ubiquitin‐ tetraurelia ARP43010_P050 UB2D2_XENLA protein ligase D2) Xenopus laevis (African clawed frog) 147 100.00% ORF Names:PPSIR1_27498 EMBL EDM79184.1OrganismPlesiocystis Xenopus tropicalis (Western clawed frog) pacifica SIR‐1 ARP55077_P050 A8WGI0_XENTR LOC100127704 protein (Silurana tropicalis) 352 85.00% rtn1 ARP49622_P050 B7ZR17_XENLA 1‐A Xenopus laevis (African clawed frog) 752 92.00% rtn1 ARP49622_P050 B7ZR15_XENLA Reticulon 1‐A Xenopus laevis (African clawed frog) 752 92.00% Xenopus tropicalis (Western clawed frog) rtn1 ARP49622_P050 RTN1_XENTR Reticulon‐1 (Silurana tropicalis) 764 92.00% rtn1 ARP49622_P050 RTN1B_XENLA Reticulon‐1‐B (RTN1.2) (xRTN1) Xenopus laevis (African clawed frog) 752 85.00% mogs ARP46708_P050 B1WBB6_XENLA LOC100158418 protein Xenopus laevis (African clawed frog) 826 84.00% Xenopus tropicalis (Western clawed frog) mogs ARP46708_P050 Q497D5_XENTR Gcs1‐prov protein (Fragment) (Silurana tropicalis) 833 84.00% LOC100145532 P100771_P050 Q641A7_XENLA Putative uncharacterized protein Xenopus laevis (African clawed frog) 684 100.00% Xenopus tropicalis (Western clawed frog) LOC100145532 P100771_P050 B1H316_XENTR LOC100145532 protein (Fragment) (Silurana tropicalis) 196 100.00% LOC100145532 P100771_P050 Q7ZXY5_XENLA Tcfe2a‐prov protein Xenopus laevis (African clawed frog) 657 83.00% Xenopus tropicalis (Western clawed frog) LOC100145532 P100771_P050 A4IIL6_XENTR Tcf3 protein (Silurana tropicalis) 655 83.00% LOC100145532 P100771_P050 TFE2_XENLA Isoform E47 Xenopus laevis (African clawed frog) 651 83.00% Transcription factor E2‐alpha (Transcription factor 3) (TCF‐3) (Transcription factor LOC100145532 P100771_P050 TFE2_XENLA XE12/XE47) Xenopus laevis (African clawed frog) 658 83.00% P100820_P050 Q66KI2_XENLA MGC81762 protein Xenopus laevis (African clawed frog) 412 84.00% P100820_P050 Q63ZR9_XENLA LOC494744 protein Xenopus laevis (African clawed frog) 409 84.00%

P100820_P050 B2L460_XENBO Transcription factor Dp‐1 alpha (Fragment) Xenopus borealis (Kenyan clawed frog) 47 84.00% Xenopus tropicalis (Western clawed frog) P100820_P050 Q6DDA9_XENTR LOC447972 protein (Fragment) (Silurana tropicalis) 107 84.00% Hypothetical LOC496643 (LOC496643 protein) Xenopus tropicalis (Western clawed frog) P100820_P050 Q5M8Z8_XENTR (Transcription factor Dp‐1) (Silurana tropicalis) 411 84.00% Xenopus tropicalis (Western clawed frog) GNAZ ARP42014_P050 Q05B25_XENTR Putative uncharacterized protein MGC145873 (Silurana tropicalis) 355 92.00% Xenopus tropicalis (Western clawed frog) GNAZ ARP34482_P050 Q05B25_XENTR Putative uncharacterized protein MGC145873 (Silurana tropicalis) 355 92.00% Elongation factor Ts, mitochondrial (EF‐Ts) (EF‐ tsfm ARP32675_P050 EFTS_XENLA TsMt) Xenopus laevis (African clawed frog) 312 92.00% Xenopus tropicalis (Western clawed frog) tsfm ARP32675_P050 A9UM97_XENTR LOC100135282 protein (Fragment) (Silurana tropicalis) 311 76.00% yy1b P100898_P050 Q91745_XENLA FIII protein Xenopus laevis (African clawed frog) 373 100.00% yy1b P100898_P050 Q6DDI1_XENLA Yy1‐a protein Xenopus laevis (African clawed frog) 390 100.00% yy1b P100898_P050 Q6AX70_XENLA MGC83552 protein Xenopus laevis (African clawed frog) 370 100.00% Xenopus tropicalis (Western clawed frog) yy1b P100898_P050 B1H2X9_XENTR Yy1 protein (Silurana tropicalis) 372 100.00% ZEB2 ARP33694_P050 Q9IB60_XENLA Smad interaction protein 1 Xenopus laevis (African clawed frog) 1214 92.00% ZEB2 ARP33694_P050 Q9I8P1_XENLA Smad‐interacting protein 1 Xenopus laevis (African clawed frog) 1213 92.00% ZEB2 ARP33694_P050 Q5U4S2_XENLA Sip1 protein Xenopus laevis (African clawed frog) 1214 92.00% CCAAT/enhancer core binding protein (Cebpa CEBPA ARP57937_P050 Q91346_XENLA protein) (Cebpa‐prov protein) Xenopus laevis (African clawed frog) 305 92.00% CEBPA ARP57937_P050 Q6INV4_XENLA MGC80223 protein Xenopus laevis (African clawed frog) 307 92.00% ARP34385_P050 Q6INV4_XENLA MGC80223 protein Xenopus laevis (African clawed frog) 307 92.00% CCAAT/enhancer binding protein (C/EBP), Xenopus tropicalis (Western clawed frog) CEBPA ARP57937_P050 Q5XHA4_XENTR alpha (Silurana tropicalis) 297 78.00% Xenopus tropicalis (Western clawed frog) CEBPA ARP57937_P050 C0LVA3_XENTR CCAAT/enhancer binding protein alpha (Silurana tropicalis) 297 78.00% CCAAT/enhancer binding protein (C/EBP), Xenopus tropicalis (Western clawed frog) ARP34385_P050 Q5XHA4_XENTR alpha (Silurana tropicalis) 297 78.00% Xenopus tropicalis (Western clawed frog) ARP34385_P050 C0LVA3_XENTR CCAAT/enhancer binding protein alpha (Silurana tropicalis) 297 78.00% CEBPA ARP57937_P050 Q52L37_XENLA MGC114753 protein Xenopus laevis (African clawed frog) 282 78.00% CEBPA ARP57937_P050 Q9YH08_XENLA CCAAT/enhancer‐binding beta protein Xenopus laevis (African clawed frog) 288 78.00% CCAAT/enhancer binding protein (C/EBP), Xenopus tropicalis (Western clawed frog) CEBPA ARP57937_P050 Q3SYP1_XENTR beta (Silurana tropicalis) 145 78.00% ARP34385_P050 Q52L37_XENLA MGC114753 protein Xenopus laevis (African clawed frog) 282 78.00% ARP34385_P050 Q9YH08_XENLA CCAAT/enhancer‐binding beta protein Xenopus laevis (African clawed frog) 288 78.00% CCAAT/enhancer binding protein (C/EBP), Xenopus tropicalis (Western clawed frog) ARP34385_P050 Q3SYP1_XENTR beta (Silurana tropicalis) 145 78.00%

MGC82597 protein (Solute carrier family 2, slc2a14 ARP43785_P050 Q6GPU6_XENLA facilitated glucose transporter member 4) Xenopus laevis (African clawed frog) 509 92.00% slc2a14 ARP43785_P050 A1A5K5_XENLA Slc2a14 protein Xenopus laevis (African clawed frog) 492 78.00% ARP46073_P050 Q8AVQ8_XENLA Hspa4 protein (Fragment) Xenopus laevis (African clawed frog) 334 100.00% ARP46073_P050 Q6PA70_XENLA LOC398863 protein (Fragment) Xenopus laevis (African clawed frog) 334 100.00% Xenopus tropicalis (Western clawed frog) ARP46073_P050 Q6P3M8_XENTR Osmotic stress protein 94 kDa (Silurana tropicalis) 835 100.00% ARP46073_P050 Q6DE62_XENLA LOC398863 protein Xenopus laevis (African clawed frog) 836 92.00% pax2a P100859_T100 PAX2B_XENLA Isoform 2 Xenopus laevis (African clawed frog) 462 92.00% pax2a P100859_T100 PAX2A_XENLA Isoform 3 Xenopus laevis (African clawed frog) 427 92.00% pax2a P100859_T100 PAX2A_XENLA Isoform 2 (Isoform 1) Xenopus laevis (African clawed frog) 394 92.00% pax2a P100859_T100 PAX2B_XENLA Paired box protein Pax‐2‐B (xPax‐2b) Xenopus laevis (African clawed frog) 494 92.00% pax2a P100859_T100 PAX2A_XENLA Paired box protein Pax‐2‐A (xPax‐2a) Xenopus laevis (African clawed frog) 497 92.00% pax2a P100859_T100 PAX2B_XENLA Isoform 4 (Isoform 11) Xenopus laevis (African clawed frog) 291 81.00% pax2a P100859_T100 PAX2B_XENLA Isoform 3 (Isoform 8) Xenopus laevis (African clawed frog) 290 81.00% pax2a P100859_T100 PAX2A_XENLA Isoform 5 (Isoform 7) Xenopus laevis (African clawed frog) 329 81.00% (EC 3.5.4.4) (Adenosine Xenopus tropicalis (Western clawed frog) ADA ARP51758_P050 ADA_XENTR aminohydrolase) (Silurana tropicalis) 358 85.00% Adenosine deaminase (EC 3.5.4.4) (Adenosine ADA ARP51758_P050 ADA_XENLA aminohydrolase) Xenopus laevis (African clawed frog) 358 85.00% ARP47535_P050 Q6GMD8_XENLA MGC81839 protein Xenopus laevis (African clawed frog) 245 100.00% emx1 ARP47535_P050 Q6AZM1_XENLA Emx1‐prov protein Xenopus laevis (African clawed frog) 240 100.00% Xenopus tropicalis (Western clawed frog) emx1 ARP47535_P050 B5DFT1_XENTR Emx2 protein (Silurana tropicalis) 247 100.00%

Homeobox protein EMX1 (Empty spiracles Xenopus tropicalis (Western clawed frog) emx1 ARP47535_P050 EMX1_XENTR homolog 1) (Empty spiracles‐like protein 1) (Silurana tropicalis) 233 100.00% ARP34377_P050 A1L3K7_XENLA LOC100037034 protein Xenopus laevis (African clawed frog) 434 92.00% ARP34377_P050 Q8AVT0_XENLA MGC53543 protein Xenopus laevis (African clawed frog) 434 85.00% ARP34377_P050 Q7SZ25_XENLA Eno1‐prov protein Xenopus laevis (African clawed frog) 434 78.00% Alpha‐enolase (EC 4.2.1.11) (2‐phospho‐D‐ glycerate hydro‐) (2‐phosphoglycerate ARP34377_P050 ENOA_XENLA dehydratase) Xenopus laevis (African clawed frog) 434 78.00% Xenopus tropicalis (Western clawed frog) si:dkey‐127j5.5 ARP57977_P050 Q6DF66_XENTR Activating transcription factor 5, gene 2 (Silurana tropicalis) 305 92.00% si:dkey‐127j5.5 ARP57977_P050 Q6DCW2_XENLA Atf5‐prov protein Xenopus laevis (African clawed frog) 308 92.00% Xenopus tropicalis (Western clawed frog) si:dkey‐127j5.5 ARP57977_P050 B0BMA6_XENTR Atf5 protein (Silurana tropicalis) 305 92.00%

ORF Names:IscW_ISCW006283 EMBL EEC08812.1OrganismIxodes scapularis (Black‐legged tick) (Deer tick) ARP51894_P050 Q6DJD1_XENLA Copa‐prov protein Xenopus laevis (African clawed frog) 1224 92.00%

ORF Names:IscW_ISCW006283 EMBL EEC08812.1OrganismIxodes scapularis Xenopus tropicalis (Western clawed frog) (Black‐legged tick) (Deer tick) ARP51894_P050 B2GUD5_XENTR LOC100158562 protein (Silurana tropicalis) 1224 92.00% ‐a ARP34212_P050 Q5U5C6_XENLA Brd2‐A‐prov protein (Fragment) Xenopus laevis (African clawed frog) 525 92.00% Xenopus tropicalis (Western clawed frog) brd2‐a ARP34212_P050 B5DE90_XENTR Brd2 protein (Silurana tropicalis) 758 92.00% brd2‐a ARP34212_P050 Q7ZYH4_XENLA Brd2‐A‐prov protein (Fragment) Xenopus laevis (African clawed frog) 539 85.00% brd2‐a ARP34212_P050 Q3KQA4_XENLA Brd2‐A‐prov protein (Fragment) Xenopus laevis (African clawed frog) 517 85.00% brd2‐a ARP34212_P050 A9JS35_XENLA Brd2‐a protein (Fragment) Xenopus laevis (African clawed frog) 517 85.00% brd2‐a ARP34212_P050 A1L3L6_XENLA Brd2‐a protein (Fragment) Xenopus laevis (African clawed frog) 518 85.00% Xenopus tropicalis (Western clawed frog) brd2‐a ARP34212_P050 A9UMC0_XENTR LOC100135304 protein (Fragment) (Silurana tropicalis) 483 78.00% ARP48047_P050 Q8AVW5_XENLA Ywhaz‐prov protein Xenopus laevis (African clawed frog) 245 92.00% ARP48047_P050 Q6PGS3_XENLA Ywhaz protein Xenopus laevis (African clawed frog) 245 92.00% Xenopus tropicalis (Western clawed frog) ARP48047_P050 1433Z_XENTR 14‐3‐3 protein zeta (Silurana tropicalis) 245 92.00% ARP48047_P050 1433Z_XENLA 14‐3‐3 protein zeta Xenopus laevis (African clawed frog) 245 92.00% Xenopus tropicalis (Western clawed frog) slc25a35 ARP44183_P050 B4F736_XENTR Putative uncharacterized protein (Silurana tropicalis) 301 90.00% ORF Names:v1g190658OrganismNematostel Xenopus tropicalis (Western clawed frog) la vectensis (Starlet sea anemone) ARP34301_P050 CP080_XENTR UPF0468 protein C16orf80 homolog (Silurana tropicalis) 193 100.00%

ORF Names:v1g190658OrganismNematostel la vectensis (Starlet sea anemone) ARP34301_P050 CP080_XENLA UPF0468 protein C16orf80 homolog Xenopus laevis (African clawed frog) 193 100.00% ARP32775_P050 Q4V7Q0_XENLA MGC115485 protein Xenopus laevis (African clawed frog) 239 92.00% Xenopus tropicalis (Western clawed frog) ARP32775_P050 Q6DJ19_XENTR HIV‐1 Tat interactive protein 2, 30kDa (Silurana tropicalis) 239 83.00% LOC398065 ARP33403_P050 Q9IBC6_XENLA Transcription factor Tbx4 (Fragment) Xenopus laevis (African clawed frog) 132 100.00% LOC398065 ARP33403_P050 B7ZRZ7_XENLA T‐box transcription factor Tbx5 Xenopus laevis (African clawed frog) 519 100.00% T‐box transcription factor TBX5 (T‐box protein Xenopus tropicalis (Western clawed frog) LOC398065 ARP33403_P050 TBX5_XENTR 5) (Silurana tropicalis) 519 100.00% T‐box transcription factor TBX5 (T‐box protein LOC398065 ARP33403_P050 TBX5_XENLA 5) Xenopus laevis (African clawed frog) 519 100.00% LOC398065 ARP33403_P050 Q5XH32_XENLA LOC495078 protein Xenopus laevis (African clawed frog) 668 100.00% Xenopus tropicalis (Western clawed frog) LOC398065 ARP33403_P050 B3DL32_XENTR Eomes protein (Silurana tropicalis) 667 100.00% Xenopus tropicalis (Western clawed frog) LOC398065 ARP33403_P050 B2GTZ2_XENTR LOC100158465 protein (Silurana tropicalis) 661 100.00% LOC398065 ARP33403_P050 A0JMS3_XENLA LOC398065 protein Xenopus laevis (African clawed frog) 666 100.00% fnbp1l ARP34191_P050 Q2TAF6_XENLA MGC132162 protein Xenopus laevis (African clawed frog) 550 84.00% Formin‐binding protein 1‐like (Transducer of Cdc42‐dependent actin assembly protein 1) Xenopus tropicalis (Western clawed frog) fnbp1l ARP34191_P050 FBP1L_XENTR (Toca‐1) (Silurana tropicalis) 550 84.00% CBP80/20‐dependent translation initiation Xenopus tropicalis (Western clawed frog) ctif ARP40789_P050 CTIF_XENTR factor (Silurana tropicalis) 583 85.00% BAT1 ARP36372_P050 Q7ZX82_XENLA Ddx39‐prov protein Xenopus laevis (African clawed frog) 427 92.00%

BAT1 ARP36372_P050 Q7ZX48_XENLA DECD‐box RNA helicase (MGC53693 protein) Xenopus laevis (African clawed frog) 427 92.00%

DEAD (Asp‐Glu‐Ala‐Asp) box polypeptide 39 Xenopus tropicalis (Western clawed frog) BAT1 ARP36372_P050 Q28EE7_XENTR (Putative uncharacterized protein LOC548754) (Silurana tropicalis) 427 92.00% Xenopus tropicalis (Western clawed frog) BAT1 ARP36372_P050 Q6P8E8_XENTR HLA‐B associated transcript 1 (Silurana tropicalis) 428 85.00% BAT1 ARP36372_P050 Q641G9_XENLA MGC81606 protein Xenopus laevis (African clawed frog) 428 85.00% ORF Names:BC1G_07256 EMBL EDN27471.1OrganismBotryotinia Probable histone deacetylase 1‐A (HD1‐A) (EC fuckeliana (strain B05.10) (Noble rot 3.5.1.98) (AB21) (HDM) (Maternally‐expressed ) (Botrytis cinerea) ARP32358_P050 HDA1A_XENLA histone deacetylase) Xenopus laevis (African clawed frog) 480 78.00% Rab40c ARP52264_P050 Q66KV7_XENLA MGC85390 protein Xenopus laevis (African clawed frog) 278 100.00% Rab40c ARP52264_P050 Q4V848_XENLA MGC114680 protein Xenopus laevis (African clawed frog) 278 100.00% Xenopus tropicalis (Western clawed frog) Rab40c ARP52264_P050 Q0VFS3_XENTR RAB40B, member RAS oncogene family (Silurana tropicalis) 278 100.00% Rab40c ARP52264_P050 Q5XHF6_XENLA Rab40 GTPase (Rab40 protein) Xenopus laevis (African clawed frog) 286 84.00% gabarapl2 ARP52325_P050 Q3B8F6_XENLA MGC131197 protein Xenopus laevis (African clawed frog) 117 100.00% Xenopus tropicalis (Western clawed frog) gabarapl2 ARP52325_P050 A4QND1_XENTR LOC100125141 protein (Silurana tropicalis) 117 100.00% Xenopus tropicalis (Western clawed frog) cdc25b AVARP03040_P050 A0JM75_XENTR Cdc25b protein (Fragment) (Silurana tropicalis) 211 92.00% cdc25b AVARP03040_P050 B2DCQ5_XENLA Cdc25B phosphatase Xenopus laevis (African clawed frog) 562 84.00% cdc25b AVARP03040_P050 Q9PVH8_XENLA Tyrosine phosphatase Cdc25A Xenopus laevis (African clawed frog) 525 84.00% cdc25b AVARP03040_P050 Q640K0_XENLA LOC398141 protein Xenopus laevis (African clawed frog) 525 84.00% Xenopus tropicalis (Western clawed frog) cdc25b AVARP03040_P050 Q28DL0_XENTR Cell division 25A (Silurana tropicalis) 527 84.00% cdc25b AVARP03040_P050 P79923_XENLA Cdc25A Xenopus laevis (African clawed frog) 521 84.00% Xenopus tropicalis (Western clawed frog) cdc25b AVARP03040_P050 A4IHE3_XENTR Cell division cycle 25 homolog A (Silurana tropicalis) 527 84.00% cdc25b AVARP03040_P050 B2DCQ6_XENLA Cdc25B phosphatase Xenopus laevis (African clawed frog) 558 76.00% cdc25b AVARP03040_P050 Q3SYM9_XENLA Cdc25a protein Xenopus laevis (African clawed frog) 525 76.00% Xenopus tropicalis (Western clawed frog) chrnb2 AVARP13020_P050 A4IIS6_XENTR Chrnb2 protein (Silurana tropicalis) 499 100.00% chrnb2 AVARP13020_P050 Q5XGU9_XENLA LOC495135 protein Xenopus laevis (African clawed frog) 499 92.00% CNOT3 ARP34318_P050 Q6DCW9_XENLA MGC80612 protein Xenopus laevis (African clawed frog) 728 100.00% Xenopus tropicalis (Western clawed frog) CNOT3 ARP34318_P050 B2GUB5_XENTR LOC100158546 protein (Silurana tropicalis) 727 100.00% Xenopus tropicalis (Western clawed frog) HDAC4 ARP34229_P050 B5DDV3_XENTR Putative uncharacterized protein (Silurana tropicalis) 870 83.00% HDAC4 ARP34229_P050 Q6P7F7_XENLA MGC68765 protein Xenopus laevis (African clawed frog) 864 75.00% Xenopus tropicalis (Western clawed frog) LOC100135374 ARP36403_P050 A9UMJ7_XENTR LOC100135374 protein (Fragment) (Silurana tropicalis) 898 78.00% mad2l1 AVARP04002_P050 Q6NU84_XENLA MGC81153 protein Xenopus laevis (African clawed frog) 203 90.00% mad2l1 AVARP04002_P050 P79935_XENLA Mad2l1 protein (XMAD2) Xenopus laevis (African clawed frog) 203 90.00% Xenopus tropicalis (Western clawed frog) mad2l1 AVARP04002_P050 A4QNK0_XENTR LOC100125170 protein (Silurana tropicalis) 203 90.00% ORF Names:GSPATT00031685001 EMBL CAK61454.1OrganismParamecium Xenopus tropicalis (Western clawed frog) tetraurelia ARP36598_P050 Q90X11_XENTR 43 (Silurana tropicalis) 379 92.00% ORF Names:GSPATT00031685001 EMBL CAK61454.1OrganismParamecium alpha‐1 protein (Connexin‐43) tetraurelia ARP36598_P050 CXA1_XENLA (Cx43) Xenopus laevis (African clawed frog) 379 92.00% ORF Names:v1g231221OrganismNematostel Hypoxia‐inducible factor 1, alpha subunit Xenopus tropicalis (Western clawed frog) la vectensis (Starlet sea anemone) ARP32904_P050 Q6P7M1_XENTR inhibitor (Silurana tropicalis) 352 100.00%

ORF Names:v1g231221OrganismNematostel la vectensis (Starlet sea anemone) ARP32904_P050 Q6IR51_XENLA MGC84481 protein Xenopus laevis (African clawed frog) 352 92.00% Xenopus tropicalis (Western clawed frog) ARP31421_P050 Q4V790_XENTR LOC613064 protein (Fragment) (Silurana tropicalis) 313 84.00% Xenopus tropicalis (Western clawed frog) spi1 ARP31421_P050 Q0P4Z3_XENTR Spi1 protein (Fragment) (Silurana tropicalis) 314 84.00% Xenopus tropicalis (Western clawed frog) spi1 ARP31421_P050 C0LVA2_XENTR SPI1 ETS transcription factor (Silurana tropicalis) 266 84.00% C3H‐2 protein (CCCH zinc finger protein C3H‐ zfp36l1 ARP33381_P050 Q9W672_XENLA 2) Xenopus laevis (African clawed frog) 345 76.00% zfp36l1 ARP33381_P050 Q498M0_XENLA MGC114600 protein Xenopus laevis (African clawed frog) 345 76.00% Xenopus tropicalis (Western clawed frog) zfp36l1 ARP33381_P050 A0JM91_XENTR Putative uncharacterized protein MGC147385 (Silurana tropicalis) 345 76.00% Zinc finger protein ZIC 4 (XlZic4) (Zinc finger zic4 ARP33669_P050 ZIC4_XENLA protein of the cerebellum 4) Xenopus laevis (African clawed frog) 530 78.00% Xenopus tropicalis (Western clawed frog) MIER3 ARP34665_P050 Q66JB5_XENTR MGC79816 protein (Silurana tropicalis) 518 84.00% Lhx3 ARP32443_P050 B7ZPU9_XENLA Xlim‐3 protein Xenopus laevis (African clawed frog) 395 85.00%

LIM/homeobox protein Lhx3 (LIM homeobox Lhx3 ARP32443_P050 LHX3_XENLA protein 3) (Homeobox protein LIM‐3) (xLIM‐3) Xenopus laevis (African clawed frog) 395 85.00% ORF Names:ACLA_040330 EMBL EAW09817.1OrganismAspergillus clavatus ARP32141_P050 Q0IHA8_XENLA MGC154481 protein Xenopus laevis (African clawed frog) 519 100.00% ORF Names:ACLA_040330 EMBL EAW09817.1OrganismAspergillus Heterogeneous nuclear ribonucleoprotein Xenopus tropicalis (Western clawed frog) clavatus ARP32141_P050 Q6P804_XENTR methyltransferase‐like 3 (S. cerevisiae) (Silurana tropicalis) 519 92.00% ORF Names:CpipJ_CPIJ008222 EMBL EDS30510.1OrganismCulex quinquefasciatus (Southern house Frequenin homolog () (Putative Xenopus tropicalis (Western clawed frog) mosquito) (Culex pungens) ARP34315_P050 Q6P844_XENTR uncharacterized protein MGC75953) (Silurana tropicalis) 190 100.00% ORF Names:CpipJ_CPIJ008222 EMBL EDS30510.1OrganismCulex quinquefasciatus (Southern house mosquito) (Culex pungens) ARP34315_P050 Q6IP34_XENLA MGC78985 protein Xenopus laevis (African clawed frog) 190 100.00% ORF Names:CpipJ_CPIJ008222 EMBL EDS30510.1OrganismCulex quinquefasciatus (Southern house Neuronal calcium sensor 1 (NCS‐1) mosquito) (Culex pungens) ARP34315_P050 NCS1_XENLA (Frequenin) Xenopus laevis (African clawed frog) 190 100.00% GF25281 P100892_P050 Q91859_XENLA Transcription factor IIE Xenopus laevis (African clawed frog) 433 85.00% KIF3C ARP33898_P050 O93478_XENLA Kinesin like protein 3 Xenopus laevis (African clawed frog) 744 78.00% DKEYP‐1A11.1 ARP34292_P050 Q90ZI5_XENLA Polycomblike 2 Xenopus laevis (African clawed frog) 487 92.00% Xenopus tropicalis (Western clawed frog) DKEYP‐1A11.1 ARP34292_P050 Q5FVA6_XENTR MGC97722 protein (Silurana tropicalis) 594 92.00% DKEYP‐1A11.1 ARP34292_P050 Q2T9I8_XENLA XPcl2 protein Xenopus laevis (African clawed frog) 593 92.00% Metal response element binding transcription Xenopus tropicalis (Western clawed frog) DKEYP‐1A11.1 ARP34292_P050 Q07FZ7_XENTR factor 2 (Fragment) (Silurana tropicalis) 312 92.00% Xenopus tropicalis (Western clawed frog) DKEYP‐1A11.1 ARP34292_P050 Q28FF9_XENTR Novel protein containing a PHD‐finger domain (Silurana tropicalis) 593 100.00% Myogenic specification paired‐box PAX7 ARP32393_P050 Q645N6_XENLA transcription factor Pax7 Xenopus laevis (African clawed frog) 500 92.00% PAX7 ARP32393_P050 B7ZRC7_XENLA LOC496378 protein Xenopus laevis (African clawed frog) 501 92.00% ORF Names:GSPATT00034464001 EMBL CAK64986.1OrganismParamecium tetraurelia ARP32449_P050 Q7ZX92_XENLA MGC80929 protein (Psmd14‐prov protein) Xenopus laevis (African clawed frog) 310 100.00% ORF Names:GSPATT00034464001 EMBL CAK64986.1OrganismParamecium Xenopus tropicalis (Western clawed frog) tetraurelia ARP32449_P050 Q5BJ72_XENTR MGC97603 protein (Silurana tropicalis) 310 100.00% ileS1 ARP34484_P050 Q71R48_XENLA BRM protein (Fragment) Xenopus laevis (African clawed frog) 309 100.00% ileS1 ARP34484_P050 Q5MMR9_XENLA Brg1 Xenopus laevis (African clawed frog) 1600 100.00% ileS1 ARP34484_P050 Q4VQ79_XENLA Brg1 Xenopus laevis (African clawed frog) 1600 100.00% Xenopus tropicalis (Western clawed frog) TFEB P100809_P050 Q08D59_XENTR Transcription factor EB (Silurana tropicalis) 433 78.00% Ldb4 ARP37731_P050 A9UM32_XENLA LIM domain binding protein 1 Xenopus laevis (African clawed frog) 375 100.00% Ldb4 ARP37731_P050 LDB1_XENLA Isoform b Xenopus laevis (African clawed frog) 304 100.00% Xenopus tropicalis (Western clawed frog) Ldb4 ARP37731_P050 LDB1_XENTR LIM domain‐binding protein 1 (LDB‐1) (Silurana tropicalis) 373 100.00%

Ldb4 ARP37731_P050 LDB1_XENLA LIM domain‐binding protein 1 (LDB‐1) (xLdb1) Xenopus laevis (African clawed frog) 375 100.00% SMYD1 ARP37022_P050 Q6GQE2_XENLA MGC80131 protein Xenopus laevis (African clawed frog) 478 84.00% Xenopus tropicalis (Western clawed frog) zbtb43 ARP32978_P050 Q0V9P6_XENTR Zinc finger and BTB domain containing 43 (Silurana tropicalis) 465 100.00% Xenopus tropicalis (Western clawed frog) Cacnb4 ARP34959_P050 B5DDZ7_XENTR Putative uncharacterized protein (Silurana tropicalis) 486 85.00% Xenopus tropicalis (Western clawed frog) ARP37464_P050 Q6NVP9_XENTR cAMP responsive element binding protein 1 (Silurana tropicalis) 327 85.00% Xenopus tropicalis (Western clawed frog) GABRB3 ARP34989_P050 A4IIN3_XENTR LOC100125027 protein (Silurana tropicalis) 474 100.00% Xenopus tropicalis (Western clawed frog) GABRB3 ARP34989_P050 A4IIK0_XENTR Gabrb3 protein (Silurana tropicalis) 475 100.00% Xenopus tropicalis (Western clawed frog) hoxa11a ARP37064_P050 Q9DDT8_XENTR Hoxa‐11 (Fragment) (Silurana tropicalis) 217 78.00% hoxa11a ARP37064_P050 Q90YE0_XENLA Homeobox protein Hox A11 (Fragment) Xenopus laevis (African clawed frog) 185 78.00%

Ordered Locus Names:BMA10229_0019OrganismBurk holderia mallei (strain NCTC 10229) ARP37678_P050 Q6NTX7_XENLA Kcnab2 protein Xenopus laevis (African clawed frog) 353 100.00%

Ordered Locus Names:BMA10229_0019OrganismBurk Voltage‐gated subunit beta‐ holderia mallei (strain NCTC 10229) ARP37678_P050 KCAB2_XENLA 2 (K(+) channel subunit beta‐2) (Kv‐beta‐2) Xenopus laevis (African clawed frog) 367 100.00%

Ordered Locus Names:BMA10229_0019OrganismBurk Potassium voltage‐gated channel, shaker‐ Xenopus tropicalis (Western clawed frog) holderia mallei (strain NCTC 10229) ARP37678_P050 Q28EG4_XENTR related subfamily, beta member 1 (Silurana tropicalis) 400 92.00%

Ordered Locus Names:BMA10229_0019OrganismBurk Potassium voltage gated channel, shaker Xenopus tropicalis (Western clawed frog) holderia mallei (strain NCTC 10229) ARP37678_P050 Q0IIY4_XENTR related subfamily, beta member 3 (Silurana tropicalis) 401 84.00%

Ordered Locus Names:BMA10229_0019OrganismBurk Voltage‐gated potassium channel subunit beta‐ holderia mallei (strain NCTC 10229) ARP37678_P050 KCAB3_XENLA 3 (K(+) channel subunit beta‐3) (Kv‐beta‐3) Xenopus laevis (African clawed frog) 401 84.00% ARP37110_P050 HNK2_XENLA Homeobox protein XENK‐2 Xenopus laevis (African clawed frog) 196 90.00% MGC53020 protein (SPIB‐a) (Spi‐B ARP31422_P050 Q9I8M5_XENLA transcription factor) Xenopus laevis (African clawed frog) 281 92.00% Xenopus tropicalis (Western clawed frog) spib ARP31422_P050 C0KXH8_XENTR SPIB (Silurana tropicalis) 273 92.00% spib ARP31422_P050 A1L3N5_XENLA LOC100037053 protein (SPIB‐b) Xenopus laevis (African clawed frog) 273 92.00% Xenopus tropicalis (Western clawed frog) spib ARP31422_P050 Q4V790_XENTR LOC613064 protein (Fragment) (Silurana tropicalis) 313 91.00% Xenopus tropicalis (Western clawed frog) spib ARP31422_P050 Q0P4Z3_XENTR Spi1 protein (Fragment) (Silurana tropicalis) 314 91.00% Xenopus tropicalis (Western clawed frog) spib ARP31422_P050 C0LVA2_XENTR SPI1 ETS transcription factor (Silurana tropicalis) 266 91.00% spib ARP31422_P050 Q6DCY3_XENLA Spic‐prov protein Xenopus laevis (African clawed frog) 162 90.00% Transcriptional adapter 3 (ADA3 homolog) (Transcriptional adapter 3‐like) (ADA3‐like Xenopus tropicalis (Western clawed frog) ARP31479_P050 TADA3_XENTR protein) (Silurana tropicalis) 432 85.00% Transcriptional adapter 3‐B (ADA3 homolog B) (Transcriptional adapter 3‐like B) (ADA3‐like ARP31479_P050 TAD3B_XENLA protein B) Xenopus laevis (African clawed frog) 432 85.00% Transcriptional adapter 3‐A (ADA3 homolog A) (Transcriptional adapter 3‐like A) (ADA3‐like ARP31479_P050 TAD3A_XENLA protein A) Xenopus laevis (African clawed frog) 432 85.00%

ORF Names:v1g93714OrganismNematostell a vectensis (Starlet sea anemone) ARP31426_P050 Q0IH90_XENLA Taf10b protein Xenopus laevis (African clawed frog) 196 100.00% RAC‐alpha serine/threonine‐protein kinase (EC 2.7.11.1) (Protein kinase Akt‐1) (xAkt) (Protein kinase B, alpha) (PKB alpha) (RAC‐PK‐ Akt1 AVARP06008_P050 AKT1_XENLA alpha) Xenopus laevis (African clawed frog) 481 100.00% LOC100137630 ARP32869_P050 A9ULW4_XENLA LOC100137630 protein (Fragment) Xenopus laevis (African clawed frog) 376 92.00%

AT‐rich interactive domain‐containing protein 3A (ARID domain‐containing protein 3A) Xenopus tropicalis (Western clawed frog) LOC100137630 ARP32869_P050 ARI3A_XENTR (Bright homolog) (Dead ringer‐like protein 1) (Silurana tropicalis) 541 92.00%

AT‐rich interactive domain‐containing protein 3A (ARID domain‐containing protein 3A) LOC100137630 ARP32869_P050 ARI3A_XENLA (Bright homolog) (Dead ringer‐like protein 1) Xenopus laevis (African clawed frog) 539 84.00% Cbx3 protein (Heterochromatin protein 1 Cbx3beta ARP34722_P050 Q802A8_XENLA gamma) Xenopus laevis (African clawed frog) 174 80.00% Cbx3beta ARP34722_P050 Q7ZWZ6_XENLA Cbx3‐prov protein Xenopus laevis (African clawed frog) 174 80.00% Heterochromatin protein 1 gamma Cbx3beta ARP34722_P050 O42156_XENLA (Fragment) Xenopus laevis (African clawed frog) 171 80.00% Chromobox protein 3 beta‐like protein Cbx3beta ARP34722_P050 B2L4A8_XENBO (Fragment) Xenopus borealis (Kenyan clawed frog) 68 80.00% Xenopus tropicalis (Western clawed frog) Cbx3beta ARP34722_P050 B1H306_XENTR Cbx3 protein (Silurana tropicalis) 174 80.00% ORF Names:PHYPADRAFT_103605 EMBL EDQ48571.1OrganismPhyscomitrella patens subsp. patens (Moss) AVARP13021_P050 Q7SY88_XENLA Chrnb3‐prov protein Xenopus laevis (African clawed frog) 460 76.00% Xenopus tropicalis (Western clawed frog) ddx25 ARP36410_P050 Q28GJ1_XENTR DEAD (Asp‐Glu‐Ala‐Asp) box polypeptide 25 (Silurana tropicalis) 479 85.00% Xenopus tropicalis (Western clawed frog) ddx25 ARP36410_P050 Q0IJ30_XENTR Zinc responsive protein Zd10A (Silurana tropicalis) 479 85.00% ddx25 ARP36410_P050 B1WBD2_XENLA DEADSouth RNA helicase Xenopus laevis (African clawed frog) 483 85.00% ATP‐dependent RNA helicase DDX25 (EC 3.6.4.13) (DEAD box protein 25) (RNA helicase ddx25 ARP36410_P050 DDX25_XENLA DEADSouth) (Xcat3) Xenopus laevis (African clawed frog) 483 85.00% Xenopus tropicalis (Western clawed frog) ARP38100_P050 Q28FV8_XENTR GATA binding protein 4 (Silurana tropicalis) 394 84.00% Xenopus tropicalis (Western clawed frog) ARP38100_P050 B3DL22_XENTR GATA binding protein 4 (Silurana tropicalis) 394 84.00% ORF Names:Bm1_08800 EMBL EDP37909.1OrganismBrugia malayi (Filarial nematode worm) AVARP13037_P050 Q7ZY66_XENLA Gdi2‐prov protein Xenopus laevis (African clawed frog) 446 92.00% ORF Names:Bm1_08800 EMBL EDP37909.1OrganismBrugia malayi (Filarial nematode worm) AVARP13037_P050 Q6DCJ9_XENLA Gdi2‐prov protein Xenopus laevis (African clawed frog) 446 92.00% ORF Names:Bm1_08800 EMBL EDP37909.1OrganismBrugia malayi GDP dissociation inhibitor 1 (Guanosine Xenopus tropicalis (Western clawed frog) (Filarial nematode worm) AVARP13037_P050 Q6DK67_XENTR diphosphate (GDP) dissociation inhibitor 3) (Silurana tropicalis) 446 84.00% HoxD3a ARP37883_P050 HXD3_XENLA Homeobox protein Hox‐D3 Xenopus laevis (African clawed frog) 413 92.00% Ordered Locus Names:lwe0419OrganismListeria welshimeri serovar 6b (strain ATCC Xenopus tropicalis (Western clawed frog) 35897 / DSM 20650 / SLCC5334) ARP32463_P050 B1WBK4_XENTR LOC100145801 protein (Fragment) (Silurana tropicalis) 401 85.00% Ordered Locus Names:lwe0419OrganismListeria welshimeri serovar 6b (strain ATCC 35897 / DSM 20650 / SLCC5334) ARP32463_P050 Q7SYR4_XENLA LOC398642 protein (Fragment) Xenopus laevis (African clawed frog) 527 84.00% Ordered Locus Names:lwe0419OrganismListeria welshimeri serovar 6b (strain ATCC 35897 / DSM 20650 / SLCC5334) ARP32463_P050 Q561K9_XENLA LOC733204 protein (Fragment) Xenopus laevis (African clawed frog) 695 84.00% Ordered Locus Names:lwe0419OrganismListeria welshimeri serovar 6b (strain ATCC Silencing mediator for retinoid and thyroid 35897 / DSM 20650 / SLCC5334) ARP32463_P050 Q1W3Z6_XENLA hormone receptor Xenopus laevis (African clawed frog) 2457 84.00% Ordered Locus Names:lwe0419OrganismListeria welshimeri serovar 6b (strain ATCC 35897 / DSM 20650 / SLCC5334) ARP32463_P050 B1H1X2_XENLA LOC100158324 protein (Fragment) Xenopus laevis (African clawed frog) 923 78.00% Xenopus tropicalis (Western clawed frog) ARP32717_P050 B2GUB9_XENTR LOC100158549 protein (Silurana tropicalis) 433 78.00% RNA exonuclease 4 (EC 3.1.‐.‐) (Exonuclease XPMC2) (Prevents mitotic catastrophe 2 Rexo4 ARP32933_P050 REXO4_XENLA protein) Xenopus laevis (African clawed frog) 421 85.00% Xenopus tropicalis (Western clawed frog) Rexo4 ARP32933_P050 Q28CZ2_XENTR Prevents mitotic catastrophe 2 homolog (Silurana tropicalis) 414 78.00% RNA exonuclease 4 (EC 3.1.‐.‐) (Exonuclease XPMC2) (Prevents mitotic catastrophe 2 Xenopus tropicalis (Western clawed frog) Rexo4 ARP32933_P050 REXO4_XENTR protein) (Silurana tropicalis) 414 78.00% Rexo4 ARP32933_P050 Q2TAR2_XENLA MGC131088 protein Xenopus laevis (African clawed frog) 417 78.00% RUNX1 ARP38073_P050 RUNX1_XENLA Isoform 2 Xenopus laevis (African clawed frog) 476 92.00%

Runt‐related transcription factor 1 (Acute myeloid leukemia 1 protein) (XAML) (Core‐ RUNX1 ARP38073_P050 RUNX1_XENLA binding factor subunit alpha‐2) (CBF‐alpha‐2) Xenopus laevis (African clawed frog) 462 92.00% smarcb1a ARP34172_P050 Q3KPK3_XENLA Putative uncharacterized protein Xenopus laevis (African clawed frog) 376 100.00% SWI/SNF‐related matrix‐associated actin‐ dependent regulator of chromatin subfamily B Xenopus tropicalis (Western clawed frog) smarcb1a ARP34172_P050 SNF5_XENTR member 1 (Silurana tropicalis) 378 100.00% SWI/SNF‐related matrix‐associated actin‐ dependent regulator of chromatin subfamily B smarcb1a ARP34172_P050 SNF5_XENLA member 1 Xenopus laevis (African clawed frog) 378 100.00% Xenopus tropicalis (Western clawed frog) UBP1 ARP32606_P050 TFCP2_XENTR Transcription factor CP2 (Silurana tropicalis) 507 100.00% UBP1 ARP32606_P050 TFCP2_XENLA Transcription factor CP2 Xenopus laevis (African clawed frog) 506 100.00% UBP1 ARP32606_P050 Q7ZXV7_XENLA Lbp‐9‐prov protein Xenopus laevis (African clawed frog) 493 92.00% UBP1 ARP32606_P050 Q7T0B5_XENLA Transcription factor LSF Xenopus laevis (African clawed frog) 506 92.00% UBP1 ARP32606_P050 Q6PCK1_XENLA MGC68878 protein Xenopus laevis (African clawed frog) 493 92.00% UBP1 ARP32606_P050 Q3KQ94_XENLA Putative uncharacterized protein Xenopus laevis (African clawed frog) 301 92.00% ORF Names:MICPUCDRAFT_56865 EMBL EEH59200.1OrganismMicromonas pusilla (strain CCMP1545) (Picoplanktonic green alga) ARP38573_P050 Q58E78_XENLA MGC85066 protein Xenopus laevis (African clawed frog) 279 85.00% ORF Names:MICPUCDRAFT_56865 EMBL EEH59200.1OrganismMicromonas pusilla (strain CCMP1545) Xenopus tropicalis (Western clawed frog) (Picoplanktonic green alga) ARP38573_P050 Q6DJ07_XENTR Activating transcription factor 1 (Silurana tropicalis) 281 85.00% ORF Names:MICPUCDRAFT_56865 EMBL EEH59200.1OrganismMicromonas pusilla (strain CCMP1545) (Picoplanktonic green alga) ARP38573_P050 Q5HZP0_XENLA LOC496344 protein Xenopus laevis (African clawed frog) 280 85.00% Mediator of RNA polymerase II transcription subunit 7 (Cofactor required for Sp1 transcriptional activation subunit 9) (CRSP complex subunit 9) (Mediator complex Xenopus tropicalis (Western clawed frog) med7 ARP33741_P050 MED7_XENTR subunit 7) (Silurana tropicalis) 229 85.00%

Mediator of RNA polymerase II transcription subunit 7‐B (Cofactor required for Sp1 transcriptional activation subunit 9‐B) (CRSP complex subunit 9‐B) (Mediator complex med7 ARP33741_P050 MED7B_XENLA subunit 7‐B) Xenopus laevis (African clawed frog) 228 85.00% Xenopus tropicalis (Western clawed frog) med7 ARP33741_P050 B3DLQ4_XENTR LOC100170525 protein (Silurana tropicalis) 241 78.00%

Mediator of RNA polymerase II transcription subunit 7‐A (Cofactor required for Sp1 transcriptional activation subunit 9‐A) (CRSP complex subunit 9‐A) (Mediator complex med7 ARP33741_P050 MED7A_XENLA subunit 7‐A) Xenopus laevis (African clawed frog) 228 78.00% ARP38089_P050 Q9IB10_XENLA Transcription factor Xenopus laevis (African clawed frog) 429 84.00% Xenopus tropicalis (Western clawed frog) ARP38089_P050 Q5XGD5_XENTR E2F transcription factor 3 (Silurana tropicalis) 427 84.00% ARP38089_P050 Q4V880_XENLA LOC398159 protein Xenopus laevis (African clawed frog) 429 84.00% Xenopus tropicalis (Western clawed frog) Foxk2 ARP34775_P050 B5DE12_XENTR Putative uncharacterized protein (Silurana tropicalis) 645 85.00%

Forkhead box protein K2 (FoxK2) (Interleukin Foxk2 ARP34775_P050 FOXK2_XENLA enhancer‐binding factor 1) (ILF1) (xFoxK1) Xenopus laevis (African clawed frog) 642 85.00% ARP38602_P050 Q9PVZ1_XENLA C‐Jun protein Xenopus laevis (African clawed frog) 312 92.00% ARP38602_P050 Q8AVE4_XENLA Jun protein Xenopus laevis (African clawed frog) 312 92.00% ARP38602_P050 Q68FJ3_XENLA MGC86303 protein Xenopus laevis (African clawed frog) 299 85.00% ARP38602_P050 Q9PVZ0_XENLA C‐Jun protein Xenopus laevis (African clawed frog) 314 85.00% ARP38602_P050 Q6GLS7_XENLA C‐Jun protein Xenopus laevis (African clawed frog) 314 85.00% ARP38602_P050 Q91714_XENLA C‐jun protein (Fragment) Xenopus laevis (African clawed frog) 71 84.00% Xenopus tropicalis (Western clawed frog) NDF2 ARP38741_P050 Q0P4T4_XENTR Neurogenic differentiation 2 (Silurana tropicalis) 353 85.00% ARP38062_P050 Q788U0_XENLA Pax‐6 (Fragment) Xenopus laevis (African clawed frog) 95 84.00% ARP38062_P050 P70053_XENLA XLPAX6 Xenopus laevis (African clawed frog) 407 84.00% Sap30bp ARP34303_P050 Q6INU0_XENLA MGC80321 protein Xenopus laevis (African clawed frog) 257 91.00% (Silent mating type information regulation 2 homolog) 1 (S. cerevisiae) Xenopus tropicalis (Western clawed frog) sirt1 ARP32386_P050 Q07FZ8_XENTR (Fragment) (Silurana tropicalis) 695 92.00% Xenopus tropicalis (Western clawed frog) sirt1 ARP32386_P050 B1H3J8_XENTR Putative uncharacterized protein (Silurana tropicalis) 659 92.00% sirt1 ARP32386_P050 A1L2V3_XENLA LOC100036963 protein Xenopus laevis (African clawed frog) 710 92.00% Transcriptional adapter 3 (ADA3 homolog) (Transcriptional adapter 3‐like) (ADA3‐like Xenopus tropicalis (Western clawed frog) TADA3 ARP38785_P050 TADA3_XENTR protein) (Silurana tropicalis) 432 100.00% Transcriptional adapter 3‐B (ADA3 homolog B) (Transcriptional adapter 3‐like B) (ADA3‐like TADA3 ARP38785_P050 TAD3B_XENLA protein B) Xenopus laevis (African clawed frog) 432 100.00% Transcriptional adapter 3‐A (ADA3 homolog A) (Transcriptional adapter 3‐like A) (ADA3‐like TADA3 ARP38785_P050 TAD3A_XENLA protein A) Xenopus laevis (African clawed frog) 432 100.00% ARP38276_P050 Q641H5_XENLA MGC81567 protein Xenopus laevis (African clawed frog) 433 92.00% Xenopus tropicalis (Western clawed frog) ARP38276_P050 B1WB29_XENTR Tead4 protein (Fragment) (Silurana tropicalis) 394 92.00% Xenopus tropicalis (Western clawed frog) ARP38276_P050 B2GU39_XENTR Tead1 protein (Fragment) (Silurana tropicalis) 513 92.00% ARP38276_P050 A8CSN2_XENLA TEF‐1 Xenopus laevis (African clawed frog) 426 92.00% tp53bp2 ARP38619_P050 Q6NTK5_XENLA LOC414498 protein (Fragment) Xenopus laevis (African clawed frog) 1139 92.00% tp53bp2 ARP38619_P050 Q4KLW6_XENLA LOC414498 protein (Fragment) Xenopus laevis (African clawed frog) 1141 92.00% Xenopus tropicalis (Western clawed frog) tp53bp2 ARP38619_P050 Q28CA9_XENTR Tumor protein binding protein, 2 (Silurana tropicalis) 1101 85.00% Xenopus tropicalis (Western clawed frog) tp53bp2 ARP38619_P050 B7ZU85_XENTR LOC548790 protein (Silurana tropicalis) 1110 85.00% tp53bp2 ARP38619_P050 Q66IP5_XENLA LOC446947 protein (Fragment) Xenopus laevis (African clawed frog) 1125 92.00% tp53bp2 ARP38619_P050 Q4KLV4_XENLA LOC446947 protein (Fragment) Xenopus laevis (African clawed frog) 1145 92.00% tp53bp2 ARP38619_P050 Q2TAH3_XENLA LOC446947 protein (Fragment) Xenopus laevis (African clawed frog) 1143 92.00% tp53bp2 ARP38619_P050 A1A5J5_XENLA LOC446947 protein Xenopus laevis (African clawed frog) 1111 92.00% Probable cytosolic iron‐sulfur protein assembly protein ciao1 (WD repeat‐containing Xenopus tropicalis (Western clawed frog) ARP38517_P050 CIAO1_XENTR protein 39) (Silurana tropicalis) 333 78.00% YY1 ARP38301_P050 Q91745_XENLA FIII protein Xenopus laevis (African clawed frog) 373 100.00% YY1 ARP38301_P050 Q6DDI1_XENLA Yy1‐a protein Xenopus laevis (African clawed frog) 390 100.00% YY1 ARP38301_P050 Q6AX70_XENLA MGC83552 protein Xenopus laevis (African clawed frog) 370 100.00% Xenopus tropicalis (Western clawed frog) YY1 ARP38301_P050 B1H2X9_XENTR Yy1 protein (Silurana tropicalis) 372 100.00% ZNF259 ARP38399_P050 B1H1S5_XENLA LOC100158293 protein Xenopus laevis (African clawed frog) 446 84.00% SNAP‐23 AVARP13090_P050 Q8AXM2_XENLA SNAP25a Xenopus laevis (African clawed frog) 206 80.00% SNAP‐23 AVARP13090_P050 Q8AXM1_XENLA SNAP25b (Snap25‐prov protein) Xenopus laevis (African clawed frog) 206 80.00% SNAP‐23 AVARP13090_P050 Q640W4_XENLA Snap25 protein Xenopus laevis (African clawed frog) 206 80.00%

Synaptosomal‐associated protein 25 Xenopus tropicalis (Western clawed frog) SNAP‐23 AVARP13090_P050 Q28HP6_XENTR (Synaptosomal‐associated protein, 25kDa) (Silurana tropicalis) 206 80.00% Xenopus tropicalis (Western clawed frog) SNAP‐23 AVARP13090_P050 A9UL74_XENTR LOC100135161 protein (Silurana tropicalis) 205 78.00% Xenopus tropicalis (Western clawed frog) P100757_P050 B1H2R4_XENTR Ctcf protein (Silurana tropicalis) 734 85.00%

ORF Names:GSTENG00021941001 EMBL CAG02747.1OrganismTetraodon nigroviridis (Green puffer) ARP32264_P050 Q9W696_XENLA Ets transcription factor (XER81 protein) Xenopus laevis (African clawed frog) 477 84.00%

ORF Names:GSTENG00021941001 EMBL CAG02747.1OrganismTetraodon Xenopus tropicalis (Western clawed frog) nigroviridis (Green puffer) ARP32264_P050 Q6P4Z1_XENTR Ets variant 1 (Silurana tropicalis) 495 84.00%

Forkhead box protein A1‐B (FoxA1b) (Fork head domain‐related protein 7') (xFD‐7') (Forkhead protein 2) (FKH‐2) (xFKH2) (Hepatocyte nuclear factor 3‐alpha homolog ARP32630_P050 FXA1B_XENLA B) (HNF3alpha homolog B) (xHNF3alpha‐B) Xenopus laevis (African clawed frog) 427 93.00%

Forkhead box protein A1‐A (FoxA1a) (Fork head domain‐related protein 7) (xFD‐7) (Hepatocyte nuclear factor 3‐alpha homolog ARP32630_P050 FXA1A_XENLA A) (HNF3alpha homolog A) (xHNF3alpha‐A) Xenopus laevis (African clawed frog) 429 93.00% Xenopus tropicalis (Western clawed frog) ARP32630_P050 FOXA1_XENTR Forkhead box protein A1 (FoxA1) (tFoxA1) (Silurana tropicalis) 428 93.00% MYST2 ARP32842_P050 Q6GPW8_XENLA MGC68869 protein Xenopus laevis (African clawed frog) 617 92.00% Xenopus tropicalis (Western clawed frog) MYST2 ARP32842_P050 A4IGQ4_XENTR Myst2 protein (Silurana tropicalis) 558 92.00% MYST2 ARP32842_P050 Q6AZV6_XENLA Myst2 protein Xenopus laevis (African clawed frog) 553 84.00% Xenopus tropicalis (Western clawed frog) satb1 ARP33362_P050 A4IIM8_XENTR Satb1 protein (Silurana tropicalis) 753 91.00%

ORF Transcriptional adapter 3 (ADA3 homolog) Names:v1g185504OrganismNematostel (Transcriptional adapter 3‐like) (ADA3‐like Xenopus tropicalis (Western clawed frog) la vectensis (Starlet sea anemone) ARP38786_P050 TADA3_XENTR protein) (Silurana tropicalis) 432 92.00%

ORF Transcriptional adapter 3‐B (ADA3 homolog B) Names:v1g185504OrganismNematostel (Transcriptional adapter 3‐like B) (ADA3‐like la vectensis (Starlet sea anemone) ARP38786_P050 TAD3B_XENLA protein B) Xenopus laevis (African clawed frog) 432 92.00%

ORF Transcriptional adapter 3‐A (ADA3 homolog A) Names:v1g185504OrganismNematostel (Transcriptional adapter 3‐like A) (ADA3‐like la vectensis (Starlet sea anemone) ARP38786_P050 TAD3A_XENLA protein A) Xenopus laevis (African clawed frog) 432 92.00% tsc22d2 ARP39137_P050 Q6NU54_XENLA MGC81241 protein Xenopus laevis (African clawed frog) 708 92.00% Transcriptional regulator Kaiso (Zinc finger and BTB domain‐containing protein 33) ARP38864_P050 KAISO_XENLA (xKaiso) Xenopus laevis (African clawed frog) 701 78.00% ORF Names:TVAG_453630 EMBL EAY17535.1OrganismTrichomonas vaginalis ARP38400_P050 B1H1S5_XENLA LOC100158293 protein Xenopus laevis (African clawed frog) 446 85.00%

Lysine‐specific 2A (EC 1.14.11.27) (F‐box and leucine‐rich repeat ORF Names:zgc:158441 ZFIN ZDB‐GENE‐ protein 11) (F‐box/LRR‐repeat protein 11) 061215‐144, zgc:158606 ZFIN ZDB‐ (JmjC domain‐containing histone GENE‐070112‐682OrganismDanio rerio demethylation protein 1A) ([Histone‐H3]‐ Xenopus tropicalis (Western clawed frog) (Zebrafish) (Brachydanio rerio) ARP31697_P050 KDM2A_XENTR lysine‐36 demethylase 1A) (Silurana tropicalis) 1146 100.00% ARP38041_P050 B7ZS63_XENLA FoxO3 protein Xenopus laevis (African clawed frog) 659 84.00% Xenopus tropicalis (Western clawed frog) foxo3 ARP38041_P050 A4IIM7_XENTR Foxo3 protein (Silurana tropicalis) 653 84.00% foxo3 ARP38041_P050 FOXO3_XENLA Forkhead box protein O3 (FoxO3) (xFoxO3) Xenopus laevis (African clawed frog) 657 84.00% Xenopus tropicalis (Western clawed frog) HBP1 ARP38976_P050 Q642N2_XENTR HMG‐box transcription factor 1 (Silurana tropicalis) 531 85.00% HBP1 ARP38976_P050 Q8JH80_XENLA HMG‐box‐containing protein HBP1 Xenopus laevis (African clawed frog) 515 78.00% HBP1 ARP38976_P050 Q6GNC7_XENLA MGC82885 protein Xenopus laevis (African clawed frog) 513 78.00% Xenopus tropicalis (Western clawed frog) ARP40041_P050 Q28BV0_XENTR Novel zinc finger protein (Silurana tropicalis) 555 84.00% Xenopus tropicalis (Western clawed frog) ARP38791_P050 Q0IJ11_XENTR Putative uncharacterized protein MGC145349 (Silurana tropicalis) 506 85.00% Xenopus tropicalis (Western clawed frog) ARP38791_P050 B1H0Y6_XENTR MGC145349 protein (Silurana tropicalis) 505 85.00% ARP38968_P050 Q801P6_XENLA LOC398578 protein (Fragment) Xenopus laevis (African clawed frog) 854 92.00% ARP38968_P050 Q7ZY63_XENLA CBTF122 protein (Fragment) Xenopus laevis (African clawed frog) 390 92.00%

ARP38968_P050 Q6GMF6_XENLA Putative uncharacterized protein (Fragment) Xenopus laevis (African clawed frog) 477 92.00% ARP38968_P050 Q2TAV5_XENLA CBTF122 protein Xenopus laevis (African clawed frog) 902 92.00% ARP38968_P050 ILF3B_XENLA Isoform 2 Xenopus laevis (African clawed frog) 698 92.00% ARP38968_P050 ILF3A_XENLA Isoform 2 (Isoform CBTF98) Xenopus laevis (African clawed frog) 695 92.00% Xenopus tropicalis (Western clawed frog) ARP38968_P050 ILF3_XENTR Interleukin enhancer‐binding factor 3 (Silurana tropicalis) 698 92.00% Interleukin enhancer‐binding factor 3‐B (Double‐stranded RNA‐binding protein 4F.2) ARP38968_P050 ILF3B_XENLA (DsRNA‐binding protein 4F.2) Xenopus laevis (African clawed frog) 898 92.00% Interleukin enhancer‐binding factor 3‐A (CCAAT box transcription factor subunit) (Double‐stranded RNA‐binding protein 4F.1) ARP38968_P050 ILF3A_XENLA (DsRNA‐binding protein 4F.1) Xenopus laevis (African clawed frog) 897 92.00% ARP32574_P050 Q6DDN0_XENLA MGC82772 protein Xenopus laevis (African clawed frog) 358 92.00%

POU domain, class 3, transcription factor 2‐B P100858_P050 P3F2B_XENLA (Transcription factor POU3‐B) (XlPOU3B) Xenopus laevis (African clawed frog) 385 92.00%

POU domain, class 3, transcription factor 2‐A P100858_P050 P3F2A_XENLA (Transcription factor POU3‐A) (XlPOU3A) Xenopus laevis (African clawed frog) 382 84.00%

ORF Names:v1g226633OrganismNematostel la vectensis (Starlet sea anemone) ARP38690_P050 Q5EAY9_XENLA MGC85051 protein Xenopus laevis (African clawed frog) 153 100.00%

ORF Names:v1g226633OrganismNematostel Sin3‐associated polypeptide, 18kDa (Sin3A‐ Xenopus tropicalis (Western clawed frog) la vectensis (Starlet sea anemone) ARP38690_P050 Q28FL5_XENTR associated protein, 18kDa) (Silurana tropicalis) 153 100.00% ORF Names:zgc:171784 EMBL AAI51980.1 ZFIN ZDB‐GENE‐071004‐ 39OrganismDanio rerio (Zebrafish) (Brachydanio rerio) ARP33429_P050 Q641H5_XENLA MGC81567 protein Xenopus laevis (African clawed frog) 433 76.00% ORF Names:zgc:171784 EMBL AAI51980.1 ZFIN ZDB‐GENE‐071004‐ 39OrganismDanio rerio (Zebrafish) Xenopus tropicalis (Western clawed frog) (Brachydanio rerio) ARP33429_P050 B1WB29_XENTR Tead4 protein (Fragment) (Silurana tropicalis) 394 76.00% Ordered Locus Names:Hore_10960OrganismHalother mothrix orenii (strain H 168 / OCM 544 Cleavage stimulation factor, 3' pre‐RNA, Xenopus tropicalis (Western clawed frog) / DSM 9562) ARP40354_P050 Q6P4J1_XENTR subunit 3, 77kDa (Silurana tropicalis) 718 92.00% Ordered Locus Names:Hore_10960OrganismHalother mothrix orenii (strain H 168 / OCM 544 / DSM 9562) ARP40354_P050 Q6DDM9_XENLA Cstf3‐prov protein Xenopus laevis (African clawed frog) 718 92.00% Ordered Locus Names:Hore_10960OrganismHalother mothrix orenii (strain H 168 / OCM 544 Cleavage stimulation factor, 3' pre‐RNA, / DSM 9562) ARP40354_P050 Q4A1D1_XENLA subunit 3, 77kDa Xenopus laevis (African clawed frog) 719 92.00% Eukaryotic translation initiation factor 3 subunit B (eIF3b) (Eukaryotic translation EIF3S9 ARP40483_P050 EIF3B_XENLA initiation factor 3 subunit 9) (eIF‐3‐eta) Xenopus laevis (African clawed frog) 688 90.00% ERAL1 ARP40599_P050 A8WH41_XENLA LOC100127247 protein (Fragment) Xenopus laevis (African clawed frog) 359 85.00% Exosome complex exonuclease MTR3 (EC 3.1.13.‐) (Exosome component 6) (mRNA Xenopus tropicalis (Western clawed frog) EXOSC6 ARP41086_P050 EXOS6_XENTR transport regulator 3 homolog) (Silurana tropicalis) 270 87.00% LOC398050 ARP40288_P050 A3KMH8_XENLA LOC398050 protein Xenopus laevis (African clawed frog) 649 92.00% Xenopus tropicalis (Western clawed frog) LOC398050 ARP40288_P050 FXR1_XENTR Isoform 2 (Silurana tropicalis) 647 92.00% LOC398050 ARP40288_P050 FXR1A_XENLA Isoform 3 Xenopus laevis (African clawed frog) 574 92.00% LOC398050 ARP40288_P050 FXR1A_XENLA Isoform 2 Xenopus laevis (African clawed frog) 649 92.00% Fragile X mental retardation syndrome‐related Xenopus tropicalis (Western clawed frog) LOC398050 ARP40288_P050 FXR1_XENTR protein 1 homolog (XtFxr1p) (Silurana tropicalis) 674 92.00% Fragile X mental retardation syndrome‐related LOC398050 ARP40288_P050 FXR1A_XENLA protein 1 homolog A (xFxr1p‐A) Xenopus laevis (African clawed frog) 676 92.00% Fragile X mental retardation syndrome‐related LOC398050 ARP40288_P050 FXR1B_XENLA protein 1 homolog B (xFxr1p‐B) Xenopus laevis (African clawed frog) 675 85.00% DKEY‐20J10.1 ARP40388_P050 Q7ZXK8_XENLA Hnrpk protein Xenopus laevis (African clawed frog) 399 100.00% Xenopus tropicalis (Western clawed frog) DKEY‐20J10.1 ARP40388_P050 Q6P363_XENTR Heterogeneous nuclear ribonucleoprotein K (Silurana tropicalis) 399 100.00% Xenopus tropicalis (Western clawed frog) DKEY‐20J10.1 ARP40388_P050 Q28HJ9_XENTR Heterogeneous nuclear ribonucleoprotein K (Silurana tropicalis) 376 100.00% DKEY‐20J10.1 ARP40388_P050 Q9PSI1_XENLA Pre‐mRNA binding K protein, hnRNP K Xenopus laevis (African clawed frog) 396 92.00% NAB1 ARP32032_P050 A9UMN5_XENLA LOC100137690 protein Xenopus laevis (African clawed frog) 497 100.00% Xenopus tropicalis (Western clawed frog) NAB1 ARP32032_P050 B1H0X5_XENTR LOC100145272 protein (Silurana tropicalis) 455 92.00% Nr2f1 P100816_P050 Q7ZXI7_XENLA Nr2f2 protein Xenopus laevis (African clawed frog) 405 100.00% Xenopus tropicalis (Western clawed frog) Nr2f1 P100816_P050 A9ULC1_XENTR Nr2f2 protein (Silurana tropicalis) 408 100.00% Nr2f1 P100816_P050 Q9W745_XENLA COUP transcription factor 1 Xenopus laevis (African clawed frog) 411 78.00% Nr2f1 P100816_P050 Q6DCH6_XENLA Nr2f2 protein Xenopus laevis (African clawed frog) 404 78.00% Xenopus tropicalis (Western clawed frog) Nr2f1 P100816_P050 A4QNF4_XENTR Nr2f1 protein (Silurana tropicalis) 410 78.00% prpf3 ARP40543_P050 Q6GQ55_XENLA LOC443589 protein (Fragment) Xenopus laevis (African clawed frog) 444 78.00% Xenopus tropicalis (Western clawed frog) prpf3 ARP40543_P050 Q6GL19_XENTR Prpf3 protein (Fragment) (Silurana tropicalis) 532 78.00% prpf3 ARP40543_P050 Q2TAV4_XENLA LOC443589 protein Xenopus laevis (African clawed frog) 679 78.00% PRP3 pre‐mRNA processing factor 3 homolog Xenopus tropicalis (Western clawed frog) prpf3 ARP40543_P050 Q28BN0_XENTR (Fragment) (Silurana tropicalis) 141 78.00% Xenopus tropicalis (Western clawed frog) prpf3 ARP40543_P050 B0BLS2_XENTR Prpf3 protein (Silurana tropicalis) 199 78.00% Rae1 ARP40301_P050 Q7ZZY7_XENLA Rae1/Gle2 (Rae1/Gle2 protein) Xenopus laevis (African clawed frog) 368 100.00% Rae1 ARP40301_P050 A3KND1_XENLA LOC100049109 protein Xenopus laevis (African clawed frog) 368 100.00%

mRNA export factor (Rae1 protein homolog) Xenopus tropicalis (Western clawed frog) Rae1 ARP40301_P050 RAE1L_XENTR (mRNA‐associated protein mrnp 41) (Silurana tropicalis) 368 100.00% ARP40302_P050 Q7ZZY7_XENLA Rae1/Gle2 (Rae1/Gle2 protein) Xenopus laevis (African clawed frog) 368 100.00% ARP40302_P050 A3KND1_XENLA LOC100049109 protein Xenopus laevis (African clawed frog) 368 100.00%

mRNA export factor (Rae1 protein homolog) Xenopus tropicalis (Western clawed frog) ARP40302_P050 RAE1L_XENTR (mRNA‐associated protein mrnp 41) (Silurana tropicalis) 368 100.00% ARP40691_P050 Q8AVB5_XENLA Sfrs1 protein (Fragment) Xenopus laevis (African clawed frog) 283 100.00% ARP40691_P050 Q0IHK2_XENLA Sfrs1 protein (Fragment) Xenopus laevis (African clawed frog) 296 100.00% ARP40691_P050 A1A628_XENLA Sfrs1 protein (Fragment) Xenopus laevis (African clawed frog) 294 100.00% Serine/arginine‐rich splicing factor 1 (Splicing Xenopus tropicalis (Western clawed frog) ARP40691_P050 SRSF1_XENTR factor, arginine/serine‐rich 1) (Silurana tropicalis) 267 100.00% snrpd1 ARP40693_P050 Q6GR62_XENLA MGC78968 protein Xenopus laevis (African clawed frog) 119 92.00% Xenopus tropicalis (Western clawed frog) snrpd1 ARP40693_P050 Q6GLH6_XENTR MGC69276 protein (Silurana tropicalis) 119 92.00% Xenopus tropicalis (Western clawed frog) trim32 ARP31692_P050 A4IIF7_XENTR LOC100124994 protein (Silurana tropicalis) 649 100.00%

Acidic (Leucine‐rich) nuclear phosphoprotein 32 family, member B (Putative Xenopus tropicalis (Western clawed frog) ARP40203_P050 Q28CW9_XENTR uncharacterized protein LOC549500) (Silurana tropicalis) 244 100.00% Acidic leucine‐rich nuclear phosphoprotein 32 ARP40203_P050 AN32A_XENLA family member A Xenopus laevis (African clawed frog) 244 100.00% ARP40203_P050 Q6GNU4_XENLA MGC80871 protein Xenopus laevis (African clawed frog) 266 92.00% Xenopus tropicalis (Western clawed frog) ARP40203_P050 Q5BL45_XENTR MGC69373 protein (Silurana tropicalis) 267 92.00% ARP40203_P050 Q2TAF9_XENLA MGC132157 protein Xenopus laevis (African clawed frog) 245 78.00% Acidic leucine‐rich nuclear phosphoprotein 32 Xenopus tropicalis (Western clawed frog) ARP40203_P050 AN32B_XENTR family member B (Silurana tropicalis) 242 78.00% Acidic leucine‐rich nuclear phosphoprotein 32 ARP40203_P050 AN32B_XENLA family member B Xenopus laevis (African clawed frog) 239 78.00% ORF Names:PANDA_007781 EMBL EFB14934.1OrganismAiluropoda melanoleuca (Giant panda) ARP41251_P050 FZD7A_XENLA Frizzled‐7‐A (Fz‐7‐A) (Xfz7‐A) Xenopus laevis (African clawed frog) 549 85.00% ORF Names:PANDA_007781 EMBL EFB14934.1OrganismAiluropoda Xenopus tropicalis (Western clawed frog) melanoleuca (Giant panda) ARP41251_P050 FZD7_XENTR Frizzled‐7 (Frz7) (Fz‐7) (Silurana tropicalis) 548 78.00% ORF Names:PANDA_007781 EMBL EFB14934.1OrganismAiluropoda melanoleuca (Giant panda) ARP41251_P050 FZD7B_XENLA Frizzled‐7‐B (Fz‐7‐B) (Xfz7‐B) Xenopus laevis (African clawed frog) 548 78.00% gipc3 ARP40601_P050 Q8UVS3_XENLA GAIP‐interacting protein (Fragment) Xenopus laevis (African clawed frog) 320 100.00% gipc3 ARP40601_P050 Q5HZ83_XENLA GIPC protein Xenopus laevis (African clawed frog) 331 100.00% Xenopus tropicalis (Western clawed frog) gipc3 ARP40601_P050 B1H191_XENTR LOC100145322 protein (Silurana tropicalis) 331 100.00% gipc3 ARP40601_P050 Q9DE30_XENLA Developmental regulator (Kermit protein) Xenopus laevis (African clawed frog) 331 92.00% GIPC PDZ domain containing family, member Xenopus tropicalis (Western clawed frog) gipc3 ARP40601_P050 Q5M7S8_XENTR 1 (Silurana tropicalis) 332 92.00% Xenopus tropicalis (Western clawed frog) gipc3 ARP40601_P050 A4QNB3_XENTR LOC100125129 protein (Silurana tropicalis) 318 78.00% ORF Names:SIAM614_21045 EMBL EAV42216.1OrganismLabrenzia Xenopus tropicalis (Western clawed frog) aggregata IAM 12614 ARP40744_P050 OLA1_XENTR Obg‐like ATPase 1 (EC 3.6.3.‐) (Silurana tropicalis) 396 85.00% ORF Names:SIAM614_21045 EMBL EAV42216.1OrganismLabrenzia aggregata IAM 12614 ARP40744_P050 Q6DDP5_XENLA Ola1 protein Xenopus laevis (African clawed frog) 281 84.00% ORF Names:SIAM614_21045 EMBL EAV42216.1OrganismLabrenzia aggregata IAM 12614 ARP40744_P050 OLA1_XENLA Obg‐like ATPase 1 (EC 3.6.3.‐) Xenopus laevis (African clawed frog) 396 84.00% ARP38136_P050 Q9PVZ1_XENLA C‐Jun protein Xenopus laevis (African clawed frog) 312 84.00% ARP38136_P050 Q8AVE4_XENLA Jun protein Xenopus laevis (African clawed frog) 312 84.00% ARP38136_P050 Q9PVZ0_XENLA C‐Jun protein Xenopus laevis (African clawed frog) 314 76.00% ARP38136_P050 Q91714_XENLA C‐jun protein (Fragment) Xenopus laevis (African clawed frog) 71 76.00% ARP38136_P050 Q6GLS7_XENLA C‐Jun protein Xenopus laevis (African clawed frog) 314 76.00% ORF Names:PANDA_003517 EMBL EFB13456.1OrganismAiluropoda melanoleuca (Giant panda) ARP38748_P050 Q6DD00_XENLA Putative uncharacterized protein Xenopus laevis (African clawed frog) 206 93.00% ORF Names:PANDA_003517 EMBL EFB13456.1OrganismAiluropoda Nuclear Y/CCAAT‐box binding factor B subunit melanoleuca (Giant panda) ARP38748_P050 O73744_XENLA NF‐YB Xenopus laevis (African clawed frog) 206 93.00% Pax3 ARP32736_P050 PAX3B_XENLA Isoform 2 Xenopus laevis (African clawed frog) 459 100.00% Pax3 ARP32736_P050 PAX3A_XENLA Isoform 2 Xenopus laevis (African clawed frog) 460 100.00% Paired box protein Pax‐3 (Paired‐domain Xenopus tropicalis (Western clawed frog) Pax3 ARP32736_P050 PAX3_XENTR transcription factor Pax3) (Silurana tropicalis) 461 100.00%

Paired box protein Pax‐3‐B (xPax3‐B) (Paired‐ Pax3 ARP32736_P050 PAX3B_XENLA domain transcription factor Pax3‐B) Xenopus laevis (African clawed frog) 483 100.00%

Paired box protein Pax‐3‐A (xPax3‐A) (Paired‐ Pax3 ARP32736_P050 PAX3A_XENLA domain transcription factor Pax3‐A) Xenopus laevis (African clawed frog) 484 100.00% Bifunctional arginine demethylase and lysyl‐ hydroxylase JMJD6‐B (EC 1.14.11.‐) (Histone arginine demethylase JMJD6‐B) (JmjC domain‐ containing protein 6‐B) (Jumonji domain‐ containing protein 6‐B) (Lysyl‐hydroxylase JMJD6‐B) (Peptide‐lysine 5‐dioxygenase JMJD6‐B) (Phosphatidylserine receptor‐B) Jmjd6 ARP31807_P050 JMD6B_XENLA (Protein PTDSR‐B) Xenopus laevis (African clawed frog) 403 100.00%

Bifunctional arginine demethylase and lysyl‐ hydroxylase JMJD6‐A (EC 1.14.11.‐) (Histone arginine demethylase JMJD6‐A) (JmjC domain‐ containing protein 6‐A) (Jumonji domain‐ containing protein 6‐A) (Lysyl‐hydroxylase JMJD6‐A) (Peptide‐lysine 5‐dioxygenase JMJD6‐A) (Phosphatidylserine receptor‐A) Jmjd6 ARP31807_P050 JMD6A_XENLA (Protein PTDSR‐A) Xenopus laevis (African clawed frog) 403 100.00% Xenopus tropicalis (Western clawed frog) ARP39521_P050 B2GU39_XENTR Tead1 protein (Fragment) (Silurana tropicalis) 513 100.00% ARP39521_P050 A8CSN2_XENLA TEF‐1 Xenopus laevis (African clawed frog) 426 100.00% ARP39521_P050 Q641H5_XENLA MGC81567 protein Xenopus laevis (African clawed frog) 433 92.00% Xenopus tropicalis (Western clawed frog) ARP39521_P050 B1WB29_XENTR Tead4 protein (Fragment) (Silurana tropicalis) 394 92.00% Sjogren syndrome antigen A2 (60kDa, ARP40535_P050 B7ZQ38_XENLA ribonucleoprotein autoantigen SS‐A/Ro) Xenopus laevis (African clawed frog) 538 85.00%

60 kDa SS‐A/Ro ribonucleoprotein (60 kDa Ro protein) (60 kDa ribonucleoprotein Ro) ARP40535_P050 RO60_XENLA (RoRNP) (TROVE domain family member 2) Xenopus laevis (African clawed frog) 538 85.00%

Cysteinyl‐tRNA synthetase, cytoplasmic (EC Xenopus tropicalis (Western clawed frog) infB ARP40295_P050 SYCC_XENTR 6.1.1.16) (Cysteine‐‐tRNA ligase) (CysRS) (Silurana tropicalis) 747 84.00%

Cysteinyl‐tRNA synthetase, cytoplasmic (EC infB ARP40295_P050 SYCC_XENLA 6.1.1.16) (Cysteine‐‐tRNA ligase) (CysRS) Xenopus laevis (African clawed frog) 747 84.00% CCR4‐NOT transcription complex subunit 7 Xenopus tropicalis (Western clawed frog) Cnot8 ARP39026_P050 CNOT7_XENTR (CCR4‐associated factor 1) (CAF‐1) (Silurana tropicalis) 285 100.00% CCR4‐NOT transcription complex subunit 7 Cnot8 ARP39026_P050 CNOT7_XENLA (CCR4‐associated factor 1) (CAF‐1) Xenopus laevis (African clawed frog) 285 100.00% Cnot8 ARP39026_P050 Q8AVW1_XENLA Cnot8‐prov protein Xenopus laevis (African clawed frog) 289 85.00% Xenopus tropicalis (Western clawed frog) Cnot8 ARP39026_P050 Q07G84_XENTR CCR4‐NOT transcription complex, subunit 8 (Silurana tropicalis) 289 85.00% ORF Names:RCOM_1574790 EMBL EEF48776.1OrganismRicinus communis (Castor bean) ARP41211_P050 Q6INR0_XENLA MGC81303 protein Xenopus laevis (African clawed frog) 448 84.00% ORF Names:RCOM_1574790 EMBL EEF48776.1OrganismRicinus communis (Castor bean) ARP41211_P050 Q6NTW0_XENLA MGC81500 protein Xenopus laevis (African clawed frog) 317 84.00% ORF Names:RCOM_1574790 EMBL EEF48776.1OrganismRicinus communis Xenopus tropicalis (Western clawed frog) (Castor bean) ARP41211_P050 Q6P636_XENTR Ddx47‐prov protein (Fragment) (Silurana tropicalis) 401 76.00%

ORF Names:Phum_PHUM438090 EMBL EEB16802.1OrganismPediculus humanus subsp. corporis (Body louse) ARP40231_P050 Q58E93_XENLA MGC84934 protein Xenopus laevis (African clawed frog) 250 100.00% ARP40625_P050 Q9W7I1_XENLA Activated protein kinase C receptor Xenopus laevis (African clawed frog) 317 100.00%

ARP40625_P050 Q8AVP6_XENLA Gnb2l1‐prov protein (LOC446289 protein) Xenopus laevis (African clawed frog) 317 100.00% Guanine nucleotide binding protein (G protein), beta polypeptide (Guanine nucleotide binding protein (G protein), beta Xenopus tropicalis (Western clawed frog) ARP40625_P050 Q6DIV0_XENTR polypeptide 2‐like 1) (Silurana tropicalis) 317 100.00% ARP40625_P050 Q5U275_XENLA LOC495666 protein Xenopus laevis (African clawed frog) 317 100.00% LOC445869 ARP38951_P050 Q6DDN5_XENLA LOC445869 protein (Fragment) Xenopus laevis (African clawed frog) 514 78.00% ORF Names:GSPATT00020565001 EMBL CAK86903.1OrganismParamecium Xenopus tropicalis (Western clawed frog) tetraurelia ARP40280_P050 OLA1_XENTR Obg‐like ATPase 1 (EC 3.6.3.‐) (Silurana tropicalis) 396 100.00% ORF Names:GSPATT00020565001 EMBL CAK86903.1OrganismParamecium tetraurelia ARP40280_P050 OLA1_XENLA Obg‐like ATPase 1 (EC 3.6.3.‐) Xenopus laevis (African clawed frog) 396 100.00% 60S ribosome subunit biogenesis protein NIP7 Xenopus tropicalis (Western clawed frog) nip7 ARP40832_P050 NIP7_XENTR homolog (Silurana tropicalis) 180 100.00% 60S ribosome subunit biogenesis protein NIP7 nip7 ARP40832_P050 NIP7_XENLA homolog Xenopus laevis (African clawed frog) 180 100.00% Xenopus tropicalis (Western clawed frog) rbm28 ARP40890_P050 B3DL94_XENTR Rbm28 protein (Silurana tropicalis) 828 84.00% Xenopus tropicalis (Western clawed frog) RNPC1 ARP40862_P050 B2GTZ5_XENTR LOC100158467 protein (Silurana tropicalis) 234 100.00% RNA‐binding protein 38 (RNA‐binding motif Xenopus tropicalis (Western clawed frog) RNPC1 ARP40862_P050 RBM38_XENTR protein 38) (Silurana tropicalis) 219 100.00% RNA‐binding protein 38 (RNA‐binding motif RNPC1 ARP40862_P050 RBM38_XENLA protein 38) (RNA‐binding protein XSeb4R) Xenopus laevis (African clawed frog) 214 100.00% RNPC1 ARP40862_P050 Q6DD49_XENLA MGC80118 protein Xenopus laevis (African clawed frog) 59 92.00% RNA‐binding protein 24 (RNA‐binding motif Xenopus tropicalis (Western clawed frog) RNPC1 ARP40862_P050 RBM24_XENTR protein 24) (Silurana tropicalis) 226 92.00% RNA‐binding protein 24‐B (MTR‐1a) (RNA‐ RNPC1 ARP40862_P050 RB24B_XENLA binding motif protein 24‐B) Xenopus laevis (African clawed frog) 224 92.00%

RNA‐binding protein 24‐A (RNA‐binding motif protein 24‐A) (RRM domain‐containing RNPC1 ARP40862_P050 RB24A_XENLA protein SEB‐4) (SEB‐4) (Xseb‐4) Xenopus laevis (African clawed frog) 225 92.00% Xenopus tropicalis (Western clawed frog) SCYE1 ARP40551_P050 B1H176_XENTR Putative uncharacterized protein (Silurana tropicalis) 172 92.00% SCYE1 ARP40551_P050 Q7ZWY7_XENLA Scye1‐prov protein Xenopus laevis (African clawed frog) 297 85.00% ORF Names:GSPATT00005963001 EMBL CAK64111.1, GSPATT00014739001 EMBL CAK79808.1OrganismParamecium tetraurelia ARP40610_P050 Q7ZX30_XENLA Spx‐prov protein Xenopus laevis (African clawed frog) 377 100.00% ORF Names:GSPATT00005963001 EMBL CAK64111.1, GSPATT00014739001 EMBL CAK79808.1OrganismParamecium Xenopus tropicalis (Western clawed frog) tetraurelia ARP40610_P050 Q6P872_XENTR Splicing factor 3b, subunit 4, 49kDa (Silurana tropicalis) 388 100.00% ORF Names:GSPATT00005963001 EMBL CAK64111.1, GSPATT00014739001 EMBL CAK79808.1OrganismParamecium tetraurelia ARP40610_P050 Q6AZR0_XENLA MGC82420 protein Xenopus laevis (African clawed frog) 383 100.00% ORF Names:GSPATT00005963001 EMBL CAK64111.1, GSPATT00014739001 EMBL CAK79808.1OrganismParamecium tetraurelia ARP40610_P050 Q4KLD9_XENLA MGC116464 protein Xenopus laevis (African clawed frog) 391 78.00% ARP40531_P050 Q7ZXI5_XENLA Snf protein Xenopus laevis (African clawed frog) 282 92.00% Xenopus tropicalis (Western clawed frog) ARP40531_P050 Q5BL54_XENTR Small nuclear ribonucleoprotein polypeptide A (Silurana tropicalis) 282 92.00% U1 small nuclear ribonucleoprotein A (U1 ARP40531_P050 SNRPA_XENLA snRNP A) (U1‐A) (U1A) Xenopus laevis (African clawed frog) 282 92.00% Xenopus tropicalis (Western clawed frog) ZFR ARP39227_P050 ZFR_XENTR Zinc finger RNA‐binding protein (Silurana tropicalis) 1065 92.00% ZFR ARP39227_P050 ZFR_XENLA Zinc finger RNA‐binding protein Xenopus laevis (African clawed frog) 1054 85.00% ARP40390_P050 Q7ZY37_XENLA Ratireb‐prov protein Xenopus laevis (African clawed frog) 891 84.00% Xenopus tropicalis (Western clawed frog) ARP40390_P050 B5DE51_XENTR Putative uncharacterized protein (Silurana tropicalis) 893 84.00% DAZL1 ARP40250_P050 B7ZS12_XENLA DAZ‐like protein Xenopus laevis (African clawed frog) 286 92.00% Deleted in azoospermia‐like‐B (DAZ‐like DAZL1 ARP40250_P050 DAZLB_XENLA protein B) (xDazl‐B) Xenopus laevis (African clawed frog) 286 92.00% Deleted in azoospermia‐like‐A (DAZ‐like DAZL1 ARP40250_P050 DAZLA_XENLA protein A) (xDazl‐A) Xenopus laevis (African clawed frog) 286 92.00% Xenopus (Silurana) epitropicalis ( DAZL1 ARP40250_P050 B2L5S6_9PIPI DAZ‐like protein beta (Fragment) clawed frog) 250 85.00% DAZL1 ARP40250_P050 B2L5S5_9PIPI DAZ‐like protein alpha (Fragment) Xenopus (Silurana) sp. new tetraploid 1 250 78.00% Xenopus (Silurana) epitropicalis (Cameroon DAZL1 ARP40250_P050 B2L5S4_9PIPI DAZ‐like protein alpha (Fragment) clawed frog) 250 78.00% Deleted in azoospermia‐like (DAZ‐like protein) Xenopus tropicalis (Western clawed frog) DAZL1 ARP40250_P050 DAZL_XENTR (Xtdazl) (Silurana tropicalis) 286 78.00% Xenopus tropicalis (Western clawed frog) ARP38384_P050 EED_XENTR Polycomb protein eed (Silurana tropicalis) 438 100.00%

ARP38384_P050 EEDB_XENLA Polycomb protein eed‐B (Xeed‐B) (psXEED) Xenopus laevis (African clawed frog) 438 100.00% ARP38384_P050 EEDA_XENLA Polycomb protein eed‐A (Xeed‐A) Xenopus laevis (African clawed frog) 438 100.00% High density lipoprotein binding protein Xenopus tropicalis (Western clawed frog) ARP40581_P050 Q6DEZ4_XENTR (Vigilin) (Silurana tropicalis) 1283 76.00% ARP40581_P050 Q7ZTN2_XENLA Hdlbp protein Xenopus laevis (African clawed frog) 1281 81.00% ARP38981_P050 Q5HZR3_XENLA LOC496326 protein Xenopus laevis (African clawed frog) 613 84.00% Probable RNA‐binding protein 46 (RNA‐ Xenopus tropicalis (Western clawed frog) MGC27016 ARP41134_P050 RBM46_XENTR binding motif protein 46) (Silurana tropicalis) 534 76.00% Xenopus tropicalis (Western clawed frog) MGC27016 ARP41134_P050 B4F6J4_XENTR Putative uncharacterized protein (Silurana tropicalis) 412 76.00% ORF Names:ACLA_020820 EMBL EAW07374.1OrganismAspergillus clavatus ARP40583_P050 Q32N91_XENLA Putative uncharacterized protein (Fragment) Xenopus laevis (African clawed frog) 375 100.00% ORF Names:ACLA_020820 EMBL EAW07374.1OrganismAspergillus clavatus ARP40583_P050 A4IFX1_XENLA Putative uncharacterized protein Xenopus laevis (African clawed frog) 372 100.00% hnrp ARP40283_P050 Q7ZX33_XENLA Hnrpa1 protein Xenopus laevis (African clawed frog) 399 92.00% hnrp ARP40283_P050 Q6IP29_XENLA LOC397751 protein Xenopus laevis (African clawed frog) 365 92.00% Xenopus tropicalis (Western clawed frog) hnrp ARP40283_P050 Q5XGF4_XENTR Heterogeneous nuclear ribonucleoprotein A1 (Silurana tropicalis) 343 92.00% hnrp ARP40283_P050 ROA1_XENLA Isoform A1‐B Xenopus laevis (African clawed frog) 351 92.00% Heterogeneous nuclear ribonucleoproteins A1 homolog (hnRNP A1) (Helix‐destabilizing protein) (Single‐strand‐binding protein) hnrp ARP40283_P050 ROA1_XENLA (hnRNP core protein A1) Xenopus laevis (African clawed frog) 365 92.00% hnrp ARP40283_P050 B7ZQP4_XENLA Putative uncharacterized protein Xenopus laevis (African clawed frog) 348 85.00% Xenopus tropicalis (Western clawed frog) hnrp ARP40283_P050 B0BM91_XENTR LOC100144993 protein (Silurana tropicalis) 383 85.00%

Heterogeneous nuclear ribonucleoprotein A3 hnrp ARP40283_P050 RO32_XENLA homolog 2 (hnRNP A3(B)) Xenopus laevis (African clawed frog) 385 85.00%

Heterogeneous nuclear ribonucleoprotein A3 hnrp ARP40283_P050 RO31_XENLA homolog 1 (hnRNP A3(A)) Xenopus laevis (African clawed frog) 373 85.00%

Snrnp70 ARP40275_P050 Q66J82_XENLA Putative uncharacterized protein (Fragment) Xenopus laevis (African clawed frog) 267 100.00% Snrnp70 ARP40275_P050 Q4V7U3_XENLA LOC397946 protein (Fragment) Xenopus laevis (African clawed frog) 351 100.00% Snrnp70 ARP40275_P050 Q32NW5_XENLA LOC397946 protein Xenopus laevis (African clawed frog) 471 100.00%

U1 small nuclear ribonucleoprotein 70 kDa Xenopus tropicalis (Western clawed frog) Snrnp70 ARP40275_P050 RU17_XENTR (U1 snRNP 70 kDa) (U1‐70K) (snRNP70) (Silurana tropicalis) 471 100.00%

U1 small nuclear ribonucleoprotein 70 kDa Snrnp70 ARP40275_P050 RU17_XENLA (U1 snRNP 70 kDa) (U1‐70K) (snRNP70) Xenopus laevis (African clawed frog) 471 100.00% ARP38278_P050 Q641H5_XENLA MGC81567 protein Xenopus laevis (African clawed frog) 433 92.00% Xenopus tropicalis (Western clawed frog) ARP38278_P050 B1WB29_XENTR Tead4 protein (Fragment) (Silurana tropicalis) 394 92.00% Xenopus tropicalis (Western clawed frog) ARP38278_P050 B2GU39_XENTR Tead1 protein (Fragment) (Silurana tropicalis) 513 85.00% ARP38278_P050 A8CSN2_XENLA TEF‐1 Xenopus laevis (African clawed frog) 426 85.00% Xenopus tropicalis (Western clawed frog) ARP40578_P050 Q5BL45_XENTR MGC69373 protein (Silurana tropicalis) 267 76.00% Xenopus tropicalis (Western clawed frog) fhl2b ARP34506_T100 B1H0Z6_XENTR LOC100145283 protein (Silurana tropicalis) 279 92.00%

Methylthioribose‐1‐phosphate isomerase (M1Pi) (MTR‐1‐P isomerase) (EC 5.3.1.23) (S‐ methyl‐5‐thioribose‐1‐phosphate isomerase) (Translation initiation factor eIF‐2B subunit Xenopus tropicalis (Western clawed frog) MRI1 ARP37363_T100 MTNA_XENTR alpha/beta/delta‐like protein) (Silurana tropicalis) 354 91.00% Methylthioribose‐1‐phosphate isomerase (M1Pi) (MTR‐1‐P isomerase) (EC 5.3.1.23) (S‐ methyl‐5‐thioribose‐1‐phosphate isomerase) (Translation initiation factor eIF‐2B subunit MRI1 ARP37363_T100 MTNA_XENLA alpha/beta/delta‐like protein) Xenopus laevis (African clawed frog) 354 91.00% aatf ARP38958_T100 Q2VPF7_XENLA Putative uncharacterized protein Xenopus laevis (African clawed frog) 535 85.00% Xenopus tropicalis (Western clawed frog) aatf ARP38958_T100 B2GUI4_XENTR Apoptosis antagonizing transcription factor (Silurana tropicalis) 513 85.00% abt1 ARP32603_T100 Q8AVR5_XENLA MGC52939 protein Xenopus laevis (African clawed frog) 238 84.00% Abt1 protein (Putative uncharacterized Xenopus tropicalis (Western clawed frog) abt1 ARP32603_T100 B1H3D3_XENTR protein) (Fragment) (Silurana tropicalis) 280 84.00% ORF Names:CBG15945 WormBase CBG15945, CBG_15945 EMBL CAP34382.1OrganismCaenorhabditis briggsae ARP32789_T100 Q6DEB8_XENLA Acadm‐prov protein Xenopus laevis (African clawed frog) 423 76.00% ORF Names:CBG15945 WormBase CBG15945, CBG_15945 EMBL CAP34382.1OrganismCaenorhabditis briggsae ARP32789_T100 Q66J53_XENLA MGC81873 protein Xenopus laevis (African clawed frog) 422 76.00% ACTN2 ARP37422_T100 Q6IP14_XENLA MGC79034 protein Xenopus laevis (African clawed frog) 894 78.00% Xenopus tropicalis (Western clawed frog) ACTN2 ARP37422_T100 Q6DF05_XENTR Actinin, alpha 2 (Silurana tropicalis) 894 78.00% ACTN2 ARP37422_T100 Q6DD73_XENLA MGC79035 protein Xenopus laevis (African clawed frog) 894 78.00% ACTN2 ARP37422_T100 Q6DFU3_XENLA Actn3‐prov protein Xenopus laevis (African clawed frog) 896 83.00% Xenopus tropicalis (Western clawed frog) ACTN2 ARP37422_T100 B4F6M1_XENTR Putative uncharacterized protein (Silurana tropicalis) 896 83.00% ARP40342_T100 Q5U4T4_XENLA LOC495438 protein Xenopus laevis (African clawed frog) 699 92.00% Xenopus tropicalis (Western clawed frog) adarb1 ARP40342_T100 A4IIV9_XENTR LOC100124739 protein (Silurana tropicalis) 719 92.00% Xenopus tropicalis (Western clawed frog) ADAT1 ARP40717_T100 A9ULE4_XENTR LOC733776 protein (Silurana tropicalis) 434 78.00% tRNA‐specific adenosine deaminase 1 (EC 3.5.4.‐) (tRNA‐specific adenosine‐37 Xenopus tropicalis (Western clawed frog) ADAT1 ARP40717_T100 ADAT1_XENTR deaminase) (Silurana tropicalis) 472 78.00% A kinase (PRKA) anchor protein (Yotiao) 9 Xenopus tropicalis (Western clawed frog) AKAP9 ARP38677_T100 Q28GK2_XENTR (Fragment) (Silurana tropicalis) 301 85.00% ARP33542_T100 Q6GQ19_XENLA MGC80441 protein Xenopus laevis (African clawed frog) 634 85.00% ankrd12 ARP33544_T100 Q5XGV5_XENLA LOC495131 protein Xenopus laevis (African clawed frog) 254 92.00% Xenopus tropicalis (Western clawed frog) ankrd12 ARP33544_T100 B3DL19_XENTR LOC100170448 protein (Silurana tropicalis) 130 92.00% Acidic (Leucine‐rich) nuclear phosphoprotein 32 family, member B (Putative Xenopus tropicalis (Western clawed frog) anp32balpha ARP40204_T100 Q28CW9_XENTR uncharacterized protein LOC549500) (Silurana tropicalis) 244 85.00% Acidic leucine‐rich nuclear phosphoprotein 32 anp32balpha ARP40204_T100 AN32A_XENLA family member A Xenopus laevis (African clawed frog) 244 85.00% anp32balpha ARP40204_T100 Q2TAF9_XENLA MGC132157 protein Xenopus laevis (African clawed frog) 245 78.00% Acidic leucine‐rich nuclear phosphoprotein 32 Xenopus tropicalis (Western clawed frog) anp32balpha ARP40204_T100 AN32B_XENTR family member B (Silurana tropicalis) 242 78.00% Acidic leucine‐rich nuclear phosphoprotein 32 anp32balpha ARP40204_T100 AN32B_XENLA family member B Xenopus laevis (African clawed frog) 239 78.00% anp32balpha ARP40204_T100 Q6GNU4_XENLA MGC80871 protein Xenopus laevis (African clawed frog) 266 76.00% Xenopus tropicalis (Western clawed frog) anp32balpha ARP40204_T100 Q5BL45_XENTR MGC69373 protein (Silurana tropicalis) 267 76.00% Acidic nuclear phosphoprotein 32 family, anp32balpha ARP40204_T100 B2L3Y1_XENBO member B alpha (Fragment) Xenopus borealis (Kenyan clawed frog) 51 76.00% ARP36586_T100 Q641H0_XENLA MGC81584 protein Xenopus laevis (African clawed frog) 502 85.00% ARP36586_T100 A1L2S9_XENLA LOC100036940 protein Xenopus laevis (African clawed frog) 500 85.00% Xenopus tropicalis (Western clawed frog) ARP36586_T100 Q6DJ57_XENTR Annexin A11 (Silurana tropicalis) 498 78.00% Xenopus tropicalis (Western clawed frog) ANXA13 ARP36590_T100 Q5EBE5_XENTR MGC108373 protein (Silurana tropicalis) 316 75.00%

ANXA2 ARP36588_T100 Q92128_XENLA Calpactin I (Annexin II) heavy chain (Fragment) Xenopus laevis (African clawed frog) 314 78.00% ANXA2 ARP36588_T100 Q7ZXM2_XENLA LOC397735 protein Xenopus laevis (African clawed frog) 340 78.00%

Annexin A2 (MGC76145 protein) (Putative Xenopus tropicalis (Western clawed frog) ANXA2 ARP36588_T100 Q6P7M0_XENTR uncharacterized protein MGC76145) (Silurana tropicalis) 340 78.00% ANXA2 ARP36588_T100 B2L4X9_XENBO Annexin A2 alpha (Fragment) Xenopus borealis (Kenyan clawed frog) 97 78.00% Annexin A2‐B (Annexin II type II) (Annexin‐2‐ B) (Calpactin I heavy chain) (Calpactin‐1 heavy ANXA2 ARP36588_T100 ANX2B_XENLA chain) (Lipocortin II) Xenopus laevis (African clawed frog) 340 78.00% Annexin A2‐A (Annexin II type I) (Annexin‐2‐A) (Calpactin I heavy chain) (Calpactin‐1 heavy ANXA2 ARP36588_T100 ANX2A_XENLA chain) (Lipocortin II) Xenopus laevis (African clawed frog) 340 78.00% Xenopus tropicalis (Western clawed frog) ANXA4 ARP36686_T100 Q28ET2_XENTR Annexin A4 (Silurana tropicalis) 321 78.00% Xenopus tropicalis (Western clawed frog) ANXA5 ARP36573_T100 Q640T3_XENTR Annexin A5 (MGC89158 protein) (Silurana tropicalis) 323 78.00% ANXA5 ARP36573_T100 Q7ZY99_XENLA LOC398472 protein (Fragment) Xenopus laevis (African clawed frog) 351 83.00% ANXA5 ARP36573_T100 Q7SZ19_XENLA LOC398472 protein (Fragment) Xenopus laevis (African clawed frog) 318 83.00% ANXA5 ARP36573_T100 Q6GR36_XENLA MGC81121 protein Xenopus laevis (African clawed frog) 323 83.00% ANXA5 ARP36573_T100 Q6DDD9_XENLA LOC398472 protein Xenopus laevis (African clawed frog) 323 83.00% ANXA6 ARP36583_T100 Q6GNT0_XENLA MGC80902 protein Xenopus laevis (African clawed frog) 673 92.00% Xenopus tropicalis (Western clawed frog) ANXA6 ARP36583_T100 Q0D2A0_XENTR LOC779574 protein (Fragment) (Silurana tropicalis) 528 85.00% ORF Names:ACLA_010320 EMBL EAW12606.1OrganismAspergillus clavatus AVARP09055_T100 Q8AVJ8_XENLA Ubtf‐b protein Xenopus laevis (African clawed frog) 701 83.00% ORF Names:ACLA_010320 EMBL EAW12606.1OrganismAspergillus Nucleolar transcription factor 1‐B (Upstream‐ clavatus AVARP09055_T100 UBF1B_XENLA binding factor 1‐B) (UBF‐1‐B) (xUBF‐2) Xenopus laevis (African clawed frog) 701 83.00% ORF Names:ACLA_010320 EMBL EAW12606.1OrganismAspergillus Nucleolar transcription factor 1‐A (Upstream‐ clavatus AVARP09055_T100 UBF1A_XENLA binding factor 1‐A) (UBF‐1‐A) (xUBF‐1) Xenopus laevis (African clawed frog) 677 83.00% aptx ARP32886_T100 Q3KPV2_XENLA LOC398657 protein Xenopus laevis (African clawed frog) 347 85.00% Xenopus tropicalis (Western clawed frog) aptx ARP32886_T100 A9UL60_XENTR FHA‐HIT protein (Silurana tropicalis) 347 85.00%

Aprataxin (EC 3.‐.‐.‐) (Forkhead‐associated Xenopus tropicalis (Western clawed frog) aptx ARP32886_T100 APTX_XENTR domain histidine triad‐like protein) (FHA‐HIT) (Silurana tropicalis) 347 85.00%

Aprataxin (EC 3.‐.‐.‐) (Forkhead‐associated aptx ARP32886_T100 APTX_XENLA domain histidine triad‐like protein) (FHA‐HIT) Xenopus laevis (African clawed frog) 347 85.00%

ORF Names:BRAFLDRAFT_83989 EMBL EEN62269.1OrganismBranchiostoma floridae (Florida lancelet) (Amphioxus) ARP40014_T100 Q3KPV2_XENLA LOC398657 protein Xenopus laevis (African clawed frog) 347 90.00%

ORF Names:BRAFLDRAFT_83989 EMBL EEN62269.1OrganismBranchiostoma Xenopus tropicalis (Western clawed frog) floridae (Florida lancelet) (Amphioxus) ARP40014_T100 A9UL60_XENTR FHA‐HIT protein (Silurana tropicalis) 347 90.00%

ORF Names:BRAFLDRAFT_83989 EMBL EEN62269.1OrganismBranchiostoma Aprataxin (EC 3.‐.‐.‐) (Forkhead‐associated Xenopus tropicalis (Western clawed frog) floridae (Florida lancelet) (Amphioxus) ARP40014_T100 APTX_XENTR domain histidine triad‐like protein) (FHA‐HIT) (Silurana tropicalis) 347 90.00%

ORF Names:BRAFLDRAFT_83989 EMBL EEN62269.1OrganismBranchiostoma Aprataxin (EC 3.‐.‐.‐) (Forkhead‐associated floridae (Florida lancelet) (Amphioxus) ARP40014_T100 APTX_XENLA domain histidine triad‐like protein) (FHA‐HIT) Xenopus laevis (African clawed frog) 347 90.00% ARP36913_T100 Q6GN53_XENLA MGC83023 protein Xenopus laevis (African clawed frog) 191 78.00% ascl1 ARP36913_T100 B7ZQW0_XENLA Achaete‐scute complex‐like 1 Xenopus laevis (African clawed frog) 199 78.00% ascl1 ARP36913_T100 ASCL1_XENLA Achaete‐scute homolog 1 Xenopus laevis (African clawed frog) 199 78.00% Atf2 ARP34151_T100 Q91576_XENLA Activating transcription factor 2 Xenopus laevis (African clawed frog) 486 92.00% Xenopus tropicalis (Western clawed frog) BRD2 ARP38939_T100 B1H318_XENTR Putative uncharacterized protein (Fragment) (Silurana tropicalis) 356 78.00% BRD2 ARP38939_T100 A1L1G8_XENLA LOC100036838 protein Xenopus laevis (African clawed frog) 783 78.00% Xenopus tropicalis (Western clawed frog) ARP34803_T100 BRD9_XENTR Bromodomain‐containing protein 9 (Silurana tropicalis) 596 84.00% ARP34803_T100 BRD9_XENLA Bromodomain‐containing protein 9 Xenopus laevis (African clawed frog) 527 84.00% Xenopus tropicalis (Western clawed frog) ARP34832_T100 BRD9_XENTR Bromodomain‐containing protein 9 (Silurana tropicalis) 596 85.00% ARP34832_T100 BRD9_XENLA Bromodomain‐containing protein 9 Xenopus laevis (African clawed frog) 527 78.00% Xenopus tropicalis (Western clawed frog) ARP34740_T100 A1A5E8_XENTR LOC100036676 protein (Silurana tropicalis) 518 85.00%

ARP34740_T100 Q5XGU7_XENLA BTB domain protein 3 (LOC495136 protein) Xenopus laevis (African clawed frog) 519 78.00% ARP39160_T100 Q8UW66_XENLA P7E4 (Fragment) Xenopus laevis (African clawed frog) 229 100.00%

ARP39160_T100 Q5XGU7_XENLA BTB domain protein 3 (LOC495136 protein) Xenopus laevis (African clawed frog) 519 100.00% ARP39160_T100 A8E625_XENLA P7E4 protein (Fragment) Xenopus laevis (African clawed frog) 423 100.00% Xenopus tropicalis (Western clawed frog) ARP39160_T100 A1A5E8_XENTR LOC100036676 protein (Silurana tropicalis) 518 100.00% Xenopus tropicalis (Western clawed frog) ARP39160_T100 BTBD6_XENTR BTB/POZ domain‐containing protein 6 (Silurana tropicalis) 529 100.00% ARP39160_T100 BTBD6_XENLA BTB/POZ domain‐containing protein 6 Xenopus laevis (African clawed frog) 529 100.00% klhl4 ARP34570_T100 Q6DDT3_XENLA MGC82233 protein Xenopus laevis (African clawed frog) 573 78.00% Xenopus tropicalis (Western clawed frog) klhl4 ARP34570_T100 B3DLV4_XENTR Klhl18 protein (Silurana tropicalis) 578 78.00% Xenopus tropicalis (Western clawed frog) klhl4 ARP34570_T100 A4IIP6_XENTR LOC100125035 protein (Silurana tropicalis) 719 78.00% ARP38015_T100 Q5XGK2_XENLA LOC495200 protein Xenopus laevis (African clawed frog) 162 100.00% Xenopus tropicalis (Western clawed frog) ARP38015_T100 Q28IY1_XENTR Basic transcription factor 3 (Silurana tropicalis) 209 92.00% Transcription factor BTF3 homolog 4 (Basic Xenopus tropicalis (Western clawed frog) ARP38015_T100 BT3L4_XENTR transcription factor 3‐like 4) (Silurana tropicalis) 158 76.00% Transcription factor BTF3 homolog 4 (Basic ARP38015_T100 BT3L4_XENLA transcription factor 3‐like 4) Xenopus laevis (African clawed frog) 158 76.00% ORF Names:GSPATT00013459001 EMBL CAK78012.1OrganismParamecium tetraurelia ARP38402_T100 B2L4F8_XENBO BUD31‐like protein (Fragment) Xenopus borealis (Kenyan clawed frog) 55 100.00% ORF Names:GSPATT00013459001 EMBL CAK78012.1OrganismParamecium Xenopus tropicalis (Western clawed frog) tetraurelia ARP38402_T100 A4IHH6_XENTR C77604 protein (Silurana tropicalis) 144 100.00% ORF Names:GSPATT00013459001 EMBL CAK78012.1OrganismParamecium tetraurelia ARP38402_T100 BUD31_XENLA Protein BUD31 homolog (Protein G10) Xenopus laevis (African clawed frog) 144 100.00% ORF Names:CpipJ_CPIJ004746 EMBL EDS44728.1OrganismCulex quinquefasciatus (Southern house mosquito) (Culex pungens) ARP34137_T100 Q6INS2_XENLA MGC81115 protein Xenopus laevis (African clawed frog) 605 100.00% ORF Names:CpipJ_CPIJ004746 EMBL EDS44728.1OrganismCulex quinquefasciatus (Southern house mosquito) (Culex pungens) ARP34137_T100 Q66J88_XENLA MGC81609 protein Xenopus laevis (African clawed frog) 631 100.00% ORF Names:CpipJ_CPIJ004746 EMBL EDS44728.1OrganismCulex quinquefasciatus (Southern house Xenopus tropicalis (Western clawed frog) mosquito) (Culex pungens) ARP34137_T100 Q0VA72_XENTR Putative uncharacterized protein MGC145031 (Silurana tropicalis) 627 100.00% Voltage‐dependent beta ARP34957_T100 Q91630_XENLA subunit Xenopus laevis (African clawed frog) 484 84.00% Voltage‐dependent calcium channel beta cacnb3 ARP34957_T100 Q91629_XENLA subunit Xenopus laevis (African clawed frog) 484 84.00% Xenopus tropicalis (Western clawed frog) cacnb3 ARP34957_T100 B0JZD2_XENTR LOC100145181 protein (Silurana tropicalis) 484 76.00% Voltage‐dependent calcium channel gamma‐8 Xenopus tropicalis (Western clawed frog) ARP37694_T100 Q0VFK5_XENTR subunit (Silurana tropicalis) 342 91.00% ORF Names:ACLA_081740 EMBL EAW06484.1OrganismAspergillus clavatus ARP30113_T100 Q6IRQ9_XENLA MGC81409 protein Xenopus laevis (African clawed frog) 120 76.00% ORF Names:ACLA_081740 EMBL EAW06484.1OrganismAspergillus clavatus ARP30113_T100 Q3B8E5_XENLA MGC131272 protein Xenopus laevis (African clawed frog) 120 76.00% ORF Names:ACLA_081740 EMBL EAW06484.1OrganismAspergillus Xenopus tropicalis (Western clawed frog) clavatus ARP30113_T100 Q07G02_XENTR Chromatin accessibility complex 1 (Silurana tropicalis) 147 76.00% ORF Names:ACLA_081740 EMBL EAW06484.1OrganismAspergillus Xenopus tropicalis (Western clawed frog) clavatus ARP30113_T100 B7ZU41_XENTR Chrac1 protein (Silurana tropicalis) 146 76.00% ORF Names:ACLA_081740 EMBL EAW06484.1OrganismAspergillus Xenopus tropicalis (Western clawed frog) clavatus ARP30113_T100 B0JZ96_XENTR Chrac1 protein (Silurana tropicalis) 144 76.00% ORF Names:ACLA_081740 EMBL EAW06484.1OrganismAspergillus LOC100135123 protein (Putative Xenopus tropicalis (Western clawed frog) clavatus ARP30113_T100 A9JSB3_XENTR uncharacterized protein LOC100135123) (Silurana tropicalis) 120 76.00% ARP40869_T100 CARFA_XENLA Protein CDKN2AIP homolog A Xenopus laevis (African clawed frog) 398 84.00% ARP40869_T100 CARFB_XENLA Protein CDKN2AIP homolog B Xenopus laevis (African clawed frog) 413 78.00% Xenopus tropicalis (Western clawed frog) ARP39623_T100 B3DL63_XENTR LOC100170461 protein (Silurana tropicalis) 500 92.00% ARP39623_T100 A5PKQ1_XENLA LOC100101300 protein Xenopus laevis (African clawed frog) 503 92.00%

E3 ubiquitin‐protein ligase Hakai (EC 6.3.2.‐) (Casitas B‐lineage lymphoma‐transforming ARP39623_T100 HAKAI_XENLA sequence‐like protein 1) (c‐Cbl‐like protein 1) Xenopus laevis (African clawed frog) 496 92.00% Cbx2 ARP39073_T100 Q63ZN4_XENLA LOC494770 protein Xenopus laevis (African clawed frog) 362 100.00% Xenopus tropicalis (Western clawed frog) Cbx2 ARP39073_T100 Q28IA4_XENTR Chromobox homolog 6 (Silurana tropicalis) 361 100.00% Cbx2 ARP39073_T100 Q6NTQ8_XENLA MGC83092 protein Xenopus laevis (African clawed frog) 360 100.00% Cbx2 ARP39073_T100 Q5M982_XENLA LOC496172 protein Xenopus laevis (African clawed frog) 361 100.00% Xenopus tropicalis (Western clawed frog) Cbx2 ARP39073_T100 Q0IIR6_XENTR Chromobox homolog 8 (Silurana tropicalis) 362 100.00% Cbx2 ARP39073_T100 Q91647_XENLA XPolycomb Xenopus laevis (African clawed frog) 521 92.00%

Cbx2 ARP39073_T100 Q6GQI4_XENLA Putative uncharacterized protein (Fragment) Xenopus laevis (African clawed frog) 262 92.00% Chromobox homolog 4 (Pc class homolog, Xenopus tropicalis (Western clawed frog) Cbx2 ARP39073_T100 Q07G82_XENTR Drosophila) (Fragment) (Silurana tropicalis) 243 92.00% Cbx2 ARP39073_T100 B7ZRU1_XENLA Chromobox homolog 4 (Polycomb) Xenopus laevis (African clawed frog) 521 92.00% Xenopus tropicalis (Western clawed frog) Cbx2 ARP39073_T100 A4IHX1_XENTR Cbx4 protein (Silurana tropicalis) 507 92.00% Xenopus tropicalis (Western clawed frog) Cbx2 ARP39073_T100 Q6DEW3_XENTR MGC89524 protein (Silurana tropicalis) 245 92.00% Cbx2 ARP39073_T100 Q9YHC4_XENLA Pc1 protein (Polycomb homolog Pc1) Xenopus laevis (African clawed frog) 471 76.00% ARP39074_T100 Q63ZN4_XENLA LOC494770 protein Xenopus laevis (African clawed frog) 362 90.00% Xenopus tropicalis (Western clawed frog) ARP39422_T100 Q0IIR6_XENTR Chromobox homolog 8 (Silurana tropicalis) 362 100.00% ARP39422_T100 Q5M982_XENLA LOC496172 protein Xenopus laevis (African clawed frog) 361 92.00% ARP39422_T100 Q6NTQ8_XENLA MGC83092 protein Xenopus laevis (African clawed frog) 360 85.00% Zinc finger protein 830 (Coiled‐coil domain‐ ARP36112_T100 ZN830_XENLA containing protein 16) Xenopus laevis (African clawed frog) 356 92.00% Zinc finger protein 830 (Coiled‐coil domain‐ Xenopus tropicalis (Western clawed frog) ARP36112_T100 ZN830_XENTR containing protein 16) (Silurana tropicalis) 357 85.00% Xenopus tropicalis (Western clawed frog) AVARP03026_T100 Q28FV7_XENTR H (Silurana tropicalis) 323 83.00% ORF Names:EAG_10903 EMBL EFN65646.1OrganismCamponotus floridanus AVARP01008_T100 Q6IRQ7_XENLA MGC81499 protein Xenopus laevis (African clawed frog) 297 100.00% ORF Names:EAG_10903 EMBL EFN65646.1OrganismCamponotus Xenopus tropicalis (Western clawed frog) floridanus AVARP01008_T100 Q66IH7_XENTR MGC89594 protein (Silurana tropicalis) 297 100.00% ORF Names:EAG_10903 EMBL Cyclin‐dependent kinase 2 (EC 2.7.11.22) EFN65646.1OrganismCamponotus (CDC2 homolog Eg1 protein kinase) (Cell floridanus AVARP01008_T100 CDK2_XENLA division protein kinase 2) Xenopus laevis (African clawed frog) 297 90.00% Xenopus tropicalis (Western clawed frog) ARP38525_T100 Q0VFL9_XENTR Cyclin‐dependent kinase 5 (Silurana tropicalis) 292 100.00% Cyclin‐dependent kinase 5 (EC 2.7.11.22) (Cell division protein kinase 5) (Neuronal cyclin‐ ARP38525_T100 CDK5_XENLA dependent kinase 5) Xenopus laevis (African clawed frog) 292 92.00% ARP38525_T100 Q9PSU0_XENLA Protein kinase (Fragment) Xenopus laevis (African clawed frog) 39 76.00% Xenopus tropicalis (Western clawed frog) ARP38525_T100 Q66IH7_XENTR MGC89594 protein (Silurana tropicalis) 297 76.00% Cyclin‐dependent kinase 2 (EC 2.7.11.22) (CDC2 homolog Eg1 protein kinase) (Cell ARP38525_T100 CDK2_XENLA division protein kinase 2) Xenopus laevis (African clawed frog) 297 76.00% ORF Names:GSPATT00037811001 EMBL CAK69372.1OrganismParamecium Xenopus tropicalis (Western clawed frog) tetraurelia ARP38526_T100 Q0VFL9_XENTR Cyclin‐dependent kinase 5 (Silurana tropicalis) 292 85.00% ORF Names:GSPATT00037811001 EMBL Cyclin‐dependent kinase 5 (EC 2.7.11.22) (Cell CAK69372.1OrganismParamecium division protein kinase 5) (Neuronal cyclin‐ tetraurelia ARP38526_T100 CDK5_XENLA dependent kinase 5) Xenopus laevis (African clawed frog) 292 85.00%

Cyclin‐dependent kinase 8 (EC 2.7.11.22) (EC 2.7.11.23) (Cell division protein kinase 8) (Mediator complex subunit cdk8) (Mediator of Xenopus tropicalis (Western clawed frog) cdk8 AVARP03050_T100 CDK8_XENTR RNA polymerase II transcription subunit cdk8) (Silurana tropicalis) 464 100.00%

Cyclin‐dependent kinase 8 (EC 2.7.11.22) (EC 2.7.11.23) (Cell division protein kinase 8) (Mediator complex subunit cdk8) (Mediator of cdk8 AVARP03050_T100 CDK8_XENLA RNA polymerase II transcription subunit cdk8) Xenopus laevis (African clawed frog) 416 100.00% ARP32841_T100 B7ZQU4_XENLA Putative uncharacterized protein Xenopus laevis (African clawed frog) 465 100.00% Xenopus tropicalis (Western clawed frog) foxn3 ARP32841_T100 B1H110_XENTR Foxn3 protein (Silurana tropicalis) 464 100.00% Xenopus tropicalis (Western clawed frog) foxn3 ARP32841_T100 A0JPB6_XENTR Forkhead box N3 (Silurana tropicalis) 486 100.00% foxn3 ARP32841_T100 FOXN3_XENLA Isoform b Xenopus laevis (African clawed frog) 463 100.00% Xenopus tropicalis (Western clawed frog) foxn3 ARP32841_T100 FOXN3_XENTR Forkhead box protein N3 (Silurana tropicalis) 464 100.00% foxn3 ARP32841_T100 FOXN3_XENLA Forkhead box protein N3 Xenopus laevis (African clawed frog) 485 100.00% ORF Names:PANDA_012137 EMBL EFB25847.1OrganismAiluropoda melanoleuca (Giant panda) ARP34967_T100 Q6DFE9_XENLA Chrna5‐prov protein Xenopus laevis (African clawed frog) 461 85.00% ARP37669_T100 Q5XGU9_XENLA LOC495135 protein Xenopus laevis (African clawed frog) 499 85.00% Xenopus tropicalis (Western clawed frog) ARP37669_T100 A4IIS6_XENTR Chrnb2 protein (Silurana tropicalis) 499 85.00% Chst4 ARP35787_T100 Q6GN39_XENLA MGC83048 protein Xenopus laevis (African clawed frog) 392 91.00% ARP33901_P050 Q6GPC7_XENLA MGC80500 protein Xenopus laevis (African clawed frog) 662 100.00% ARP33901_P050 Q5XG61_XENLA MGC80500 protein (Fragment) Xenopus laevis (African clawed frog) 292 100.00% ARP33901_P050 Q6PF78_XENLA Kif2‐A‐prov protein Xenopus laevis (African clawed frog) 686 92.00% Kinesin‐like protein KIF2A (Kinesin‐related ARP33901_P050 KIF2A_XENLA protein xKIF2) Xenopus laevis (African clawed frog) 682 92.00% Kinesin family member 2C (Novel protein Xenopus tropicalis (Western clawed frog) ARP33901_P050 Q6DEY2_XENTR similar to KIF2C) (Silurana tropicalis) 734 91.00% Kinesin‐like protein KIF2C (Kinesin central ARP33901_P050 KIF2C_XENLA motor 1) (xKCM1) Xenopus laevis (African clawed frog) 730 91.00% Xenopus tropicalis (Western clawed frog) ARP46851_P050 Q0P4T5_XENTR Beta‐site APP‐cleaving enzyme 1 (Silurana tropicalis) 502 85.00% Xenopus tropicalis (Western clawed frog) Sp1 ARP43585_P050 Q6P817_XENTR (Silurana tropicalis) 509 100.00% Sp1 ARP43585_P050 Q6NRD9_XENLA MGC83896 protein Xenopus laevis (African clawed frog) 723 93.00% Transcription factor Sox‐1 (SRY (Sex Xenopus tropicalis (Western clawed frog) ARP38720_P050 SOX1_XENTR determining region Y)‐box 1) (Silurana tropicalis) 401 92.00%

Transcription factor Sox‐1 (XlSox1) (xSox1) Sox2 ARP38720_P050 SOX1_XENLA (SRY (sex determining region Y)‐box 1) Xenopus laevis (African clawed frog) 393 92.00% Sox2 ARP38720_P050 D2WK21_XENLA Sex‐determining region Y‐box 2 Xenopus laevis (African clawed frog) 311 78.00% Transcription factor Sox‐2 (SRY (sex Xenopus tropicalis (Western clawed frog) Sox2 ARP38720_P050 SOX2_XENTR determining region Y)‐box 2) (Silurana tropicalis) 311 78.00%

Transcription factor Sox‐2 (XSox2) (XlSox‐2) Sox2 ARP38720_P050 SOX2_XENLA (SRY (sex determining region Y)‐box 2) Xenopus laevis (African clawed frog) 311 78.00% GGT1 ARP41639_T100 Q6GNQ9_XENLA MGC80945 protein Xenopus laevis (African clawed frog) 573 92.00% Xenopus tropicalis (Western clawed frog) GGT1 ARP41639_T100 Q6DIS4_XENTR Gamma‐glutamyltransferase 1 (Silurana tropicalis) 571 92.00% GGT1 ARP41639_T100 Q32NR5_XENLA MGC130919 protein Xenopus laevis (African clawed frog) 573 92.00% Novel protein similar to Gamma‐ Xenopus tropicalis (Western clawed frog) GGT1 ARP41639_T100 Q07G16_XENTR glutamyltranspeptidase (Fragment) (Silurana tropicalis) 411 92.00% tspan3b ARP46642_P050 Q5XH66_XENLA LOC495251 protein Xenopus laevis (African clawed frog) 253 100.00% tspan3b ARP46642_P050 Q4FZN3_XENLA MGC116528 protein Xenopus laevis (African clawed frog) 253 100.00% Xenopus tropicalis (Western clawed frog) tspan3b ARP46642_P050 Q28F99_XENTR Tetraspanin 3 (Silurana tropicalis) 253 100.00% ZNF750 ARP33586_T100 Q19BJ7_XENLA Superficial protein 1 Xenopus laevis (African clawed frog) 676 92.00% Xenopus tropicalis (Western clawed frog) ZNF750 ARP33586_T100 ZN750_XENTR Protein ZNF750 (Silurana tropicalis) 671 92.00% ZNF750 ARP33586_T100 B3A0S8_XENLA expression nuclear inhibitor Xenopus laevis (African clawed frog) 674 85.00% ZNF750 ARP33586_T100 ZN750_XENLA Protein ZNF750 Xenopus laevis (African clawed frog) 674 85.00% ORF Names:GSPATT00006518001 EMBL CAK66019.1OrganismParamecium tetraurelia ARP46857_P050 Q6DFH4_XENLA Chic2‐prov protein Xenopus laevis (African clawed frog) 166 93.00% ORF Names:GSPATT00006518001 EMBL CAK66019.1OrganismParamecium LOC100135210 protein (Putative Xenopus tropicalis (Western clawed frog) tetraurelia ARP46857_P050 A9ULJ0_XENTR uncharacterized protein LOC100135210) (Silurana tropicalis) 166 93.00% ORF Names:GSPATT00006518001 EMBL CAK66019.1OrganismParamecium Xenopus tropicalis (Western clawed frog) tetraurelia ARP46857_P050 B1H2D5_XENTR LOC100145395 protein (Silurana tropicalis) 169 92.00% ORF Names:GSPATT00006518001 EMBL Protein SLC7A6OS (Solute carrier family 7 CAK66019.1OrganismParamecium member 6 opposite strand transcript Xenopus tropicalis (Western clawed frog) tetraurelia ARP46857_P050 S7A6O_XENTR homolog) (Silurana tropicalis) 314 80.00% ARP40428_T100 Q7ZYN0_XENLA Rbms1‐prov protein Xenopus laevis (African clawed frog) 374 92.00% Xenopus tropicalis (Western clawed frog) ARP40428_T100 Q0IIS2_XENTR LOC100036596 protein (Silurana tropicalis) 406 92.00% Xenopus tropicalis (Western clawed frog) ARP40428_T100 B4F6H4_XENTR LOC100036596 protein (Silurana tropicalis) 399 92.00% ARP33025_T100 Q6DDS4_XENLA LOC445859 protein (Fragment) Xenopus laevis (African clawed frog) 124 92.00% ORF Names:POPTRDRAFT_780566 EMBL EEF00340.1OrganismPopulus trichocarpa (Western balsam poplar) (Populus balsamifera subsp. trichocarpa) ARP32445_P050 Q7ZWJ0_XENLA Ak7‐a protein (Fragment) Xenopus laevis (African clawed frog) 709 78.00% ORF Names:POPTRDRAFT_780566 EMBL EEF00340.1OrganismPopulus trichocarpa (Western balsam poplar) (Populus balsamifera subsp. Xenopus tropicalis (Western clawed frog) trichocarpa) ARP32445_P050 Q5M7Q2_XENTR Adenylate kinase 7 (Silurana tropicalis) 710 78.00% ORF Names:POPTRDRAFT_780566 EMBL EEF00340.1OrganismPopulus trichocarpa (Western balsam poplar) (Populus balsamifera subsp. trichocarpa) ARP32445_P050 Q5FWX2_XENLA Ak7‐A‐prov protein Xenopus laevis (African clawed frog) 710 78.00% Xenopus tropicalis (Western clawed frog) lrp2bp ARP42515_P050 B0BMM0_XENTR LOC100145071 protein (Silurana tropicalis) 341 92.00% lrp2bp ARP42515_P050 LR2BP_XENLA LRP2‐binding protein Xenopus laevis (African clawed frog) 341 92.00% Ubiquitin‐conjugating enzyme E2 S‐A (EC 6.3.2.19) (Ubiquitin carrier protein S‐A) ube2s‐a ARP43155_P050 UB2SA_XENLA (Ubiquitin‐protein ligase S‐A) Xenopus laevis (African clawed frog) 223 100.00% Ubiquitin‐conjugating enzyme E2 S (EC 6.3.2.19) (Ubiquitin carrier protein S) Xenopus tropicalis (Western clawed frog) ube2s‐a ARP43155_P050 UBE2S_XENTR (Ubiquitin‐protein ligase S) (Silurana tropicalis) 211 76.00% Ubiquitin‐conjugating enzyme E2 S‐C (EC 6.3.2.19) (Ubiquitin carrier protein S‐C) ube2s‐a ARP43155_P050 UB2SC_XENLA (Ubiquitin‐protein ligase S‐C) Xenopus laevis (African clawed frog) 211 76.00% Ubiquitin‐conjugating enzyme E2 S‐B (EC 6.3.2.19) (Ubiquitin carrier protein S‐B) ube2s‐a ARP43155_P050 UB2SB_XENLA (Ubiquitin‐protein ligase S‐B) Xenopus laevis (African clawed frog) 211 76.00% Xenopus tropicalis (Western clawed frog) ARP57751_P050 A9UM99_XENTR LOC100135284 protein (Silurana tropicalis) 320 85.00% RAB11B ARP48246_P050 Q8AVV4_XENLA Rab11b protein Xenopus laevis (African clawed frog) 218 92.00% RAB11B ARP48246_P050 Q641B7_XENLA LOC494642 protein Xenopus laevis (African clawed frog) 218 92.00% RAB11B, member RAS oncogene family (RAB11B, member RAS oncogene family, gene Xenopus tropicalis (Western clawed frog) RAB11B ARP48246_P050 Q5XH99_XENTR 1) (Silurana tropicalis) 218 92.00% RAB11B, member RAS oncogene family, gene Xenopus tropicalis (Western clawed frog) RAB11B ARP48246_P050 Q6DJB4_XENTR 2 (Silurana tropicalis) 218 85.00% RAB11B ARP48246_P050 Q5M991_XENLA LOC496163 protein Xenopus laevis (African clawed frog) 218 85.00% Xenopus tropicalis (Western clawed frog) RAB11B ARP48246_P050 B1H201_XENTR LOC100145363 protein (Silurana tropicalis) 218 78.00% ProtoflgCK ARP41477_P050 Q7ZYQ9_XENLA Ckm‐prov protein Xenopus laevis (African clawed frog) 381 78.00% ProtoflgCK ARP41477_P050 Q7LZG8_XENLA Creatine kinase (EC 2.7.3.2) (Fragment) Xenopus laevis (African clawed frog) 302 78.00% Xenopus tropicalis (Western clawed frog) ProtoflgCK ARP41477_P050 Q6P347_XENTR Creatine kinase, muscle (Silurana tropicalis) 381 78.00% ProtoflgCK ARP41477_P050 Q8AVH2_XENLA Ckb‐prov protein Xenopus laevis (African clawed frog) 376 78.00% Creatine kinase isozyme IV (EC 2.7.3.2) ProtoflgCK ARP41477_P050 Q7LZG6_XENLA (Fragment) Xenopus laevis (African clawed frog) 361 78.00% Xenopus tropicalis (Western clawed frog) ProtoflgCK ARP41477_P050 Q28GS7_XENTR Creatine kinase, brain (Silurana tropicalis) 381 78.00% Xenopus tropicalis (Western clawed frog) zfpl1 ARP58101_P050 ZFPL1_XENTR Zinc finger protein‐like 1 (Silurana tropicalis) 320 85.00% zfpl1 ARP58101_P050 ZFPL1_XENLA Zinc finger protein‐like 1 Xenopus laevis (African clawed frog) 320 85.00% Xenopus tropicalis (Western clawed frog) ARP42900_P050 Q6P3Q8_XENTR Symplekin (Silurana tropicalis) 1159 76.00% yipf6 ARP42717_P050 A2RV54_XENLA LOC100037131 protein Xenopus laevis (African clawed frog) 232 100.00% Xenopus tropicalis (Western clawed frog) yipf6 ARP42717_P050 YIPF6_XENTR Protein YIPF6 (YIP1 family member 6) (Silurana tropicalis) 233 100.00%

ORF Names:ACLA_006330 EMBL Proteasome (Prosome macropain) subunit EAW11876.1OrganismAspergillus beta type 6 (Proteasome (Prosome, Xenopus tropicalis (Western clawed frog) clavatus ARP56469_P050 Q6P7M7_XENTR macropain) subunit, beta type, 6) (Silurana tropicalis) 233 92.00% ORF Names:ACLA_006330 EMBL EAW11876.1OrganismAspergillus clavatus ARP56469_P050 Q3KQ92_XENLA MGC130855 protein Xenopus laevis (African clawed frog) 247 92.00% ORF Names:ACLA_006330 EMBL EAW11876.1OrganismAspergillus clavatus ARP56469_P050 Q3KPV9_XENLA LOC397716 protein Xenopus laevis (African clawed frog) 233 92.00% ORF Names:ACLA_006330 EMBL EAW11876.1OrganismAspergillus clavatus ARP56469_P050 O13000_XENLA Proteasome subunit Y Xenopus laevis (African clawed frog) 230 92.00% V‐type proton ATPase subunit C 1 (V‐ATPase subunit C 1) (Vacuolar proton pump subunit C Xenopus tropicalis (Western clawed frog) ATP6V1C2 ARP58589_P050 VATC1_XENTR 1) (Silurana tropicalis) 382 92.00% V‐type proton ATPase subunit C 1 (V‐ATPase subunit C 1) (Vacuolar proton pump subunit C ATP6V1C2 ARP58589_P050 VATC1_XENLA 1) Xenopus laevis (African clawed frog) 382 92.00%

ORF CTD nuclear envelope phosphatase 1 (EC Names:v1g130476OrganismNematostel 3.1.3.16) (Serine/threonine‐protein Xenopus tropicalis (Western clawed frog) la vectensis (Starlet sea anemone) ARP47144_P050 CNEP1_XENTR phosphatase dullard) (Silurana tropicalis) 244 100.00%

ORF CTD nuclear envelope phosphatase 1 (EC Names:v1g130476OrganismNematostel 3.1.3.16) (Serine/threonine‐protein la vectensis (Starlet sea anemone) ARP47144_P050 CNEP1_XENLA phosphatase dullard) Xenopus laevis (African clawed frog) 244 100.00% sfrs10 ARP40529_T100 Q7ZTM8_XENLA LOC398448 protein (Fragment) Xenopus laevis (African clawed frog) 306 100.00% sfrs10 ARP40529_T100 Q6GPZ8_XENLA LOC443599 protein (Fragment) Xenopus laevis (African clawed frog) 304 100.00% Splicing factor, arginine/serine‐rich 10 Xenopus tropicalis (Western clawed frog) sfrs10 ARP40529_T100 Q6DES6_XENTR (Transformer 2 homolog) (Silurana tropicalis) 293 100.00% sfrs10 ARP40529_T100 Q2VPF1_XENLA LOC398448 protein Xenopus laevis (African clawed frog) 298 100.00% Xenopus tropicalis (Western clawed frog) PAFAH1B1 ARP56107_P050 LIS1_XENTR ‐1 homolog (Silurana tropicalis) 410 100.00% PAFAH1B1 ARP56107_P050 LIS1_XENLA Lissencephaly‐1 homolog Xenopus laevis (African clawed frog) 410 100.00% ARP37938_T100 Q6DDN0_XENLA MGC82772 protein Xenopus laevis (African clawed frog) 358 100.00% GF17299 ARP43026_P050 Q6AZI4_XENLA LOC446231 protein (Fragment) Xenopus laevis (African clawed frog) 153 100.00% Xenopus tropicalis (Western clawed frog) GF17299 ARP43026_P050 Q5BJ50_XENTR Ubiquitin‐conjugating enzyme E2L 3 (Silurana tropicalis) 154 100.00% GF17299 ARP43026_P050 Q4QR35_XENLA LOC446231 protein Xenopus laevis (African clawed frog) 154 100.00% FKBP2 ARP58465_P050 Q7ZYC8_XENLA MGC53657 protein Xenopus laevis (African clawed frog) 141 84.00% FKBP2 ARP58465_P050 Q6GQ21_XENLA MGC80429 protein Xenopus laevis (African clawed frog) 141 84.00% LOC100135178 protein (Putative Xenopus tropicalis (Western clawed frog) FKBP2 ARP58465_P050 A9ULB7_XENTR uncharacterized protein LOC100135178) (Silurana tropicalis) 141 84.00% ORF Names:SIAM614_10688 EMBL EAV46290.1OrganismLabrenzia Enoyl‐CoA hydratase domain‐containing aggregata IAM 12614 ARP48911_T100 B7ZPE3_XENLA protein 3, mitochondrial Xenopus laevis (African clawed frog) 294 85.00% ORF Names:SIAM614_10688 EMBL EAV46290.1OrganismLabrenzia Enoyl‐CoA hydratase domain‐containing aggregata IAM 12614 ARP48911_T100 ECHD3_XENLA protein 3, mitochondrial Xenopus laevis (African clawed frog) 294 85.00% ARP37167_T100 Q9PUN0_XENLA Metastasis associated 1‐like protein Xenopus laevis (African clawed frog) 670 92.00% ARP37167_T100 Q6AZP0_XENLA MGC83056 protein Xenopus laevis (African clawed frog) 672 92.00% ARP37167_T100 Q4V7T0_XENLA Mta2 protein Xenopus laevis (African clawed frog) 669 92.00% ORF Names:PANDA_015607 EMBL EFB19260.1OrganismAiluropoda Xenopus tropicalis (Western clawed frog) melanoleuca (Giant panda) ARP33252_P050 Q28CP0_XENTR SRY (Sex determining region Y)‐box 4 (Silurana tropicalis) 387 92.00% ARP32999_P050 Q7T0V4_XENLA Tcf2 protein Xenopus laevis (African clawed frog) 561 84.00% Hepatocyte nuclear factor 1‐beta (HNF‐1B) ARP32999_P050 HNF1B_XENLA (LFB3) (XlFB3) Xenopus laevis (African clawed frog) 561 84.00% ARP32999_P050 Q6PAX5_XENLA MGC68543 protein Xenopus laevis (African clawed frog) 561 84.00% Xenopus tropicalis (Western clawed frog) ARP53727_P050 B1H2S5_XENTR LOC100127554 protein (Silurana tropicalis) 575 91.00% ARP53727_P050 A9JS44_XENLA LOC100127303 protein (Fragment) Xenopus laevis (African clawed frog) 333 91.00% Xenopus tropicalis (Western clawed frog) ARP53727_P050 A7MC58_XENTR LOC100127554 protein (Fragment) (Silurana tropicalis) 331 91.00% si:dkey‐9a20.6 ARP32615_T100 Q6PA68_XENLA MGC68777 protein Xenopus laevis (African clawed frog) 353 92.00% Xenopus tropicalis (Western clawed frog) si:dkey‐9a20.6 ARP32615_T100 Q5M8F8_XENTR Cortactin (Silurana tropicalis) 553 76.00%

ORF Names:v1g106520OrganismNematostel la vectensis (Starlet sea anemone) ARP46131_P050 B7ZSK0_XENLA (XCAP‐C) Xenopus laevis (African clawed frog) 1290 100.00% Structural maintenance of ORF protein 4 (SMC protein 4) (SMC‐4) Names:v1g106520OrganismNematostel (Chromosome assembly protein XCAP‐C) la vectensis (Starlet sea anemone) ARP46131_P050 SMC4_XENLA (Chromosome‐associated protein C) Xenopus laevis (African clawed frog) 1290 100.00% U2AF1 ARP40326_P050 Q32NM8_XENLA MGC131026 protein Xenopus laevis (African clawed frog) 245 100.00% Xenopus tropicalis (Western clawed frog) U2AF1 ARP40326_P050 Q28C63_XENTR U2(RNU2) small nuclear RNA auxiliary factor 1 (Silurana tropicalis) 243 100.00% Xenopus tropicalis (Western clawed frog) U2AF1 ARP40326_P050 A4QNB4_XENTR LOC733934 protein (Fragment) (Silurana tropicalis) 241 100.00% Fubp3 ARP40474_P050 Q8AX85_XENLA RNA‐binding protein VgRBP71 Xenopus laevis (African clawed frog) 672 100.00% Fubp3 ARP40474_P050 Q6PAA0_XENLA MGC68532 protein Xenopus laevis (African clawed frog) 546 100.00% Xenopus tropicalis (Western clawed frog) Fubp3 ARP40474_P050 B3DM06_XENTR LOC100170586 protein (Silurana tropicalis) 449 100.00% Fubp3 ARP40474_P050 B1WBB7_XENLA LOC100158419 protein Xenopus laevis (African clawed frog) 674 100.00% Xenopus tropicalis (Western clawed frog) Fubp3 ARP40474_P050 A4IH51_XENTR Fubp3 protein (Silurana tropicalis) 546 100.00% Fubp3 ARP40474_P050 Q8AX84_XENLA FUSE binding protein‐like protein Xenopus laevis (African clawed frog) 610 92.00% Fubp3 ARP40474_P050 Q7ZXS1_XENLA Fubp1 protein Xenopus laevis (African clawed frog) 653 92.00% Far upstream element (FUSE) binding protein Xenopus tropicalis (Western clawed frog) Fubp3 ARP40474_P050 Q6P3Q5_XENTR 1 (Silurana tropicalis) 653 92.00% MGC78835 protein (Putative uncharacterized Fubp3 ARP40474_P050 Q6IRB9_XENLA protein MGC78835) Xenopus laevis (African clawed frog) 653 92.00% Xenopus tropicalis (Western clawed frog) Fubp3 ARP40474_P050 Q28BR2_XENTR OTTXETP00000007035 (Silurana tropicalis) 653 92.00% Xenopus tropicalis (Western clawed frog) ARP35477_T100 B2GU68_XENTR Kcnh5 protein (Silurana tropicalis) 985 92.00% Ordered Locus Names:TP04_0010OrganismTheileria RNA‐binding protein 24 (RNA‐binding motif Xenopus tropicalis (Western clawed frog) parva ARP41156_P050 RBM24_XENTR protein 24) (Silurana tropicalis) 226 92.00%

Ordered Locus RNA‐binding protein 24‐A (RNA‐binding motif Names:TP04_0010OrganismTheileria protein 24‐A) (RRM domain‐containing parva ARP41156_P050 RB24A_XENLA protein SEB‐4) (SEB‐4) (Xseb‐4) Xenopus laevis (African clawed frog) 225 92.00% Ordered Locus Names:TP04_0010OrganismTheileria RNA‐binding protein 24‐B (MTR‐1a) (RNA‐ parva ARP41156_P050 RB24B_XENLA binding motif protein 24‐B) Xenopus laevis (African clawed frog) 224 85.00% Ordered Locus Names:TP04_0010OrganismTheileria RNA‐binding protein 38 (RNA‐binding motif Xenopus tropicalis (Western clawed frog) parva ARP41156_P050 RBM38_XENTR protein 38) (Silurana tropicalis) 219 90.00% Ordered Locus Names:TP04_0010OrganismTheileria RNA‐binding protein 38 (RNA‐binding motif parva ARP41156_P050 RBM38_XENLA protein 38) (RNA‐binding protein XSeb4R) Xenopus laevis (African clawed frog) 214 90.00% spon2a ARP52335_P050 Q6DCM4_XENLA Spon2‐prov protein Xenopus laevis (African clawed frog) 313 92.00% Xenopus tropicalis (Western clawed frog) spon2a ARP52335_P050 Q0P4H5_XENTR Putative uncharacterized protein MGC147505 (Silurana tropicalis) 313 92.00% ARP32995_T100 Q7T0T7_XENLA Nr2f6 protein Xenopus laevis (African clawed frog) 389 76.00% Nuclear receptor subfamily 2, group F, Xenopus tropicalis (Western clawed frog) ARP32995_T100 Q6GL59_XENTR member 6 (Silurana tropicalis) 389 76.00% ARP51759_P050 Q5PPV0_XENLA LOC496072 protein Xenopus laevis (African clawed frog) 496 78.00% ARP44042_P050 B4F6R3_XENLA Putative uncharacterized protein Xenopus laevis (African clawed frog) 548 91.00% Xenopus tropicalis (Western clawed frog) LRRC8E ARP49916_P050 LRC8E_XENTR Leucine‐rich repeat‐containing protein 8E (Silurana tropicalis) 806 76.00%

LRRC8E ARP49916_P050 LRC8E_XENLA Leucine‐rich repeat‐containing protein 8E Xenopus laevis (African clawed frog) 806 76.00%

ORF Names:AGAP005352OrganismAnophel es gambiae (African malaria mosquito) ARP45363_P050 Q6NRX9_XENLA MGC81077 protein Xenopus laevis (African clawed frog) 462 100.00%

ORF Names:AGAP005352OrganismAnophel es gambiae (African malaria mosquito) ARP45363_P050 Q6DD82_XENLA Ptpn2‐prov protein Xenopus laevis (African clawed frog) 468 100.00%

ORF Names:AGAP005352OrganismAnophel es gambiae (African malaria mosquito) ARP45363_P050 Q6GMA0_XENLA MGC81984 protein Xenopus laevis (African clawed frog) 428 92.00%

ORF Names:AGAP005352OrganismAnophel Xenopus tropicalis (Western clawed frog) es gambiae (African malaria mosquito) ARP45363_P050 B1H2K9_XENTR Putative uncharacterized protein (Silurana tropicalis) 433 85.00% 6‐pyruvoyl‐tetrahydropterin synthase/dimerization cofactor of hepatocyte Xenopus tropicalis (Western clawed frog) pcbd1 ARP37979_P050 Q640A1_XENTR nuclear factor 1 alpha (TCF1) (Silurana tropicalis) 104 85.00% pcbd1 ARP37979_P050 Q63ZS4_XENLA LOC397951 protein Xenopus laevis (African clawed frog) 104 85.00% pcbd1 ARP37979_P050 Q5HZL2_XENLA LOC496367 protein Xenopus laevis (African clawed frog) 104 85.00%

Pterin‐4‐alpha‐carbinolamine dehydratase (PHS) (EC 4.2.1.96) (4‐alpha‐hydroxy‐ tetrahydropterin dehydratase) (Dimerization cofactor of hepatocyte nuclear factor 1‐alpha) (DCoH) (Dimerization cofactor of HNF1) (xDCoH) (Phenylalanine hydroxylase‐ stimulating protein) (Pterin carbinolamine pcbd1 ARP37979_P050 PHS_XENLA dehydratase) (PCD) Xenopus laevis (African clawed frog) 104 78.00% prrc1‐a ARP52545_P050 PRRCB_XENLA Protein PRRC1‐B Xenopus laevis (African clawed frog) 442 100.00% prrc1‐a ARP52545_P050 PRRCA_XENLA Protein PRRC1‐A Xenopus laevis (African clawed frog) 442 100.00% Xenopus tropicalis (Western clawed frog) prrc1‐a ARP52545_P050 PRRC1_XENTR Protein PRRC1 (Silurana tropicalis) 443 100.00% ORF Names:GSPATT00039204001 EMBL CAK77377.1OrganismParamecium tetraurelia ARP55757_P050 Q6NRT4_XENLA MGC81470 protein Xenopus laevis (African clawed frog) 179 92.00% ORF Names:GSPATT00039204001 EMBL CAK77377.1OrganismParamecium ARF related‐like protein 5 (Cg7197‐prov tetraurelia ARP55757_P050 Q7ZXC2_XENLA protein) Xenopus laevis (African clawed frog) 179 78.00% ORF Names:GSPATT00039204001 EMBL CAK77377.1OrganismParamecium tetraurelia ARP55757_P050 Q6AZG4_XENLA LOC446243 protein (Fragment) Xenopus laevis (African clawed frog) 198 78.00% ORF Names:GSPATT00039204001 EMBL CAK77377.1OrganismParamecium tetraurelia ARP55757_P050 Q4QR18_XENLA LOC446243 protein Xenopus laevis (African clawed frog) 179 78.00% ORF Names:GSPATT00039204001 EMBL CAK77377.1OrganismParamecium Novel protein similar to mouse ADP‐ Xenopus tropicalis (Western clawed frog) tetraurelia ARP55757_P050 Q28HQ6_XENTR ribosylation factor‐like 12 Arl12 (Silurana tropicalis) 179 78.00% ORF Names:GSPATT00039204001 EMBL CAK77377.1OrganismParamecium tetraurelia ARP55757_P050 Q6DDN3_XENLA Trim23‐prov protein Xenopus laevis (African clawed frog) 588 100.00% ORF Names:GSPATT00039204001 EMBL CAK77377.1OrganismParamecium Xenopus tropicalis (Western clawed frog) tetraurelia ARP55757_P050 Q6DIM7_XENTR ADP‐ribosylation factor‐like 8 (Silurana tropicalis) 179 76.00% ORF Names:RCOM_1077820 EMBL EEF47385.1OrganismRicinus communis (Castor bean) ARP39353_T100 Q6GNJ7_XENLA LOC443654 protein (Fragment) Xenopus laevis (African clawed frog) 536 85.00% ORF Names:RCOM_1077820 EMBL EEF47385.1OrganismRicinus communis (Castor bean) ARP39353_T100 Q6GPQ0_XENLA Dcp1 protein (Fragment) Xenopus laevis (African clawed frog) 535 85.00% ORF Names:RCOM_1077820 EMBL EEF47385.1OrganismRicinus communis (Castor bean) ARP39353_T100 Q45NB8_XENLA MRNA decapping enzyme Xenopus laevis (African clawed frog) 532 85.00% rtcA ARP40478_P050 Q6GMZ1_XENLA MGC84552 protein Xenopus laevis (African clawed frog) 351 100.00% Xenopus tropicalis (Western clawed frog) rtcA ARP40478_P050 B1H169_XENTR LOC100145308 protein (Silurana tropicalis) 351 100.00% Xenopus tropicalis (Western clawed frog) hs3st5 ARP49083_P050 B1WBI7_XENTR LOC100145790 protein (Silurana tropicalis) 345 100.00% ARP48432_P050 Q7SZT8_XENLA Gpsn2‐prov protein Xenopus laevis (African clawed frog) 308 85.00% ARP48432_P050 Q6GP78_XENLA MGC80625 protein Xenopus laevis (African clawed frog) 308 85.00% Xenopus tropicalis (Western clawed frog) ARP48432_P050 Q68EQ7_XENTR Gpsn2 protein (Silurana tropicalis) 308 85.00% Xenopus tropicalis (Western clawed frog) ARP48432_P050 Q5BKP0_XENTR Gpsn2 protein (Silurana tropicalis) 346 85.00% Xenopus tropicalis (Western clawed frog) ARP49726_P050 Q5EAM2_XENTR Cadherin 11, type 2, OB‐cadherin (Osteoblast) (Silurana tropicalis) 794 91.00% ARP49726_P050 O93264_XENLA Cadherin Xenopus laevis (African clawed frog) 794 91.00%

ARP49726_P050 Q9DFS1_XENLA Cadherin 6, type 2, K‐cadherin (Cadherin‐6) Xenopus laevis (African clawed frog) 792 84.00% ARP49726_P050 Q9DFS0_XENLA Cadherin‐6' Xenopus laevis (African clawed frog) 792 84.00% ARP49726_P050 B7ZQK9_XENLA Cadherin 6, type 2, K‐cadherin Xenopus laevis (African clawed frog) 792 84.00% ORF Names:GSPATT00008099001 EMBL CAK71552.1, GSPATT00021028001 EMBL CAK87386.1, GSPATT00022933001 EMBL CAK89760.1, GSPATT00023594001 EMBL CAK90417.1, GSPATT00024306001 EMBL CAK91577.1OrganismParamecium tetraurelia ARP51261_P050 Q5M781_XENLA Dynein light chain dlc8b (Dynll2 protein) Xenopus laevis (African clawed frog) 89 92.00% ORF Names:GSPATT00008099001 EMBL CAK71552.1, GSPATT00021028001 EMBL CAK87386.1, GSPATT00022933001 EMBL CAK89760.1, GSPATT00023594001 EMBL CAK90417.1, GSPATT00024306001 EMBL CAK91577.1OrganismParamecium Xenopus tropicalis (Western clawed frog) tetraurelia ARP51261_P050 B0BM87_XENTR Dynll2 protein (Silurana tropicalis) 89 92.00% ORF Names:GSPATT00008099001 EMBL CAK71552.1, GSPATT00021028001 EMBL CAK87386.1, GSPATT00022933001 EMBL CAK89760.1, GSPATT00023594001 EMBL CAK90417.1, GSPATT00024306001 EMBL CAK91577.1OrganismParamecium tetraurelia ARP51261_P050 Q6NTS8_XENLA MGC68763 protein Xenopus laevis (African clawed frog) 89 100.00% ORF Names:GSPATT00008099001 EMBL CAK71552.1, GSPATT00021028001 EMBL CAK87386.1, GSPATT00022933001 EMBL CAK89760.1, GSPATT00023594001 EMBL CAK90417.1, GSPATT00024306001 EMBL CAK91577.1OrganismParamecium tetraurelia ARP51261_P050 Q6GPR8_XENLA Dynein light chain dlc8a (MGC82658 protein) Xenopus laevis (African clawed frog) 89 100.00% ORF Names:GSPATT00008099001 EMBL CAK71552.1, GSPATT00021028001 EMBL CAK87386.1, GSPATT00022933001 EMBL CAK89760.1, GSPATT00023594001 EMBL CAK90417.1, GSPATT00024306001 EMBL CAK91577.1OrganismParamecium Dynein light chain 2 (Dynein, light chain, LC8‐ Xenopus tropicalis (Western clawed frog) tetraurelia ARP51261_P050 Q6DEU5_XENTR type 1) (Silurana tropicalis) 89 100.00% Trim33 ARP32677_P050 Q2TAS5_XENLA MGC130965 protein Xenopus laevis (African clawed frog) 677 92.00% Trim33 ARP32677_P050 Q2VPL5_XENLA MGC131247 protein Xenopus laevis (African clawed frog) 543 75.00% Xenopus tropicalis (Western clawed frog) Trim33 ARP32677_P050 Q28FL8_XENTR Tripartite motif‐containing 33 (Fragment) (Silurana tropicalis) 320 75.00% Xenopus tropicalis (Western clawed frog) Trim33 ARP32677_P050 Q0P4M9_XENTR Tripartite motif‐containing 33 (Silurana tropicalis) 711 75.00% Trim33 ARP32677_P050 B7ZRX2_XENLA Ectodermin Xenopus laevis (African clawed frog) 1091 75.00% Trim33 ARP32677_P050 B7ZRU5_XENLA Ectodermin Xenopus laevis (African clawed frog) 1091 75.00%

E3 ubiquitin‐protein ligase TRIM33 (EC 6.3.2.‐) (Ectodermin) (Transcription intermediary factor 1‐gamma) (TIF1‐gamma) (Tripartite Trim33 ARP32677_P050 TRI33_XENLA motif‐containing protein 33) Xenopus laevis (African clawed frog) 1091 75.00% UNC5B ARP45510_P050 C5IAW9_XENLA Unc‐5‐like protein B Xenopus laevis (African clawed frog) 942 78.00% receptor UNC5B (Protein Xunc‐5) UNC5B ARP45510_P050 UNC5B_XENLA (Protein unc‐5 homolog) Xenopus laevis (African clawed frog) 943 78.00%

ORF Names:DKEY‐20I20.13‐001 EMBL CAM56607.1OrganismDanio rerio Xenopus tropicalis (Western clawed frog) (Zebrafish) (Brachydanio rerio) ARP40063_P050 B2GU19_XENTR LOC100158487 protein (Silurana tropicalis) 302 78.00% ORF Names:DKEY‐20I20.13‐001 EMBL CAM56607.1OrganismDanio rerio Xenopus tropicalis (Western clawed frog) (Zebrafish) (Brachydanio rerio) ARP40063_P050 B1H2A9_XENTR LOC100145374 protein (Silurana tropicalis) 302 78.00% mpkC ARP56432_P050 Q6DFK6_XENLA Xp42 protein Xenopus laevis (African clawed frog) 361 92.00% Xenopus tropicalis (Western clawed frog) mpkC ARP56432_P050 Q28H11_XENTR Mitogen‐activated protein kinase 1 (Silurana tropicalis) 361 92.00%

Mitogen‐activated protein kinase 1 (MAP kinase 1) (MAPK 1) (EC 2.7.11.24) (M phase MAP kinase) (Myelin basic protein kinase) mpkC ARP56432_P050 MK01_XENLA (MBP kinase) (Myelin xP42 protein kinase) Xenopus laevis (African clawed frog) 361 92.00% ORF Names:GLP15_2416 EMBL EFO62580.1OrganismGiardia lamblia Xenopus tropicalis (Western clawed frog) P15 ARP31990_T100 Q0VA44_XENTR Insm1 protein (Fragment) (Silurana tropicalis) 303 92.00% ORF Names:GLP15_2416 EMBL EFO62580.1OrganismGiardia lamblia P15 ARP31990_T100 A7UKY7_XENLA Insuloma‐associated 1 Xenopus laevis (African clawed frog) 433 92.00% ORF Names:GLP15_2416 EMBL EFO62580.1OrganismGiardia lamblia Xenopus tropicalis (Western clawed frog) P15 ARP31990_T100 A4IHR5_XENTR Insm1 protein (Silurana tropicalis) 441 92.00% FMO5 ARP44434_P050 Q6PA74_XENLA MGC68715 protein Xenopus laevis (African clawed frog) 531 100.00% Xenopus tropicalis (Western clawed frog) FMO5 ARP44434_P050 Q6DF15_XENTR MGC89174 protein (Silurana tropicalis) 534 100.00% Rapgef1 ARP54753_P050 Q6GP24_XENLA MGC80732 protein Xenopus laevis (African clawed frog) 1035 100.00% Rap guanine nucleotide exchange factor (GEF) Xenopus tropicalis (Western clawed frog) Rapgef1 ARP54753_P050 Q28C28_XENTR 1 (Silurana tropicalis) 1035 100.00% Xenopus tropicalis (Western clawed frog) Rapgef1 ARP54753_P050 B2GU51_XENTR LOC733953 protein (Silurana tropicalis) 1066 100.00% Xenopus tropicalis (Western clawed frog) Fhl1 ARP31902_P050 Q6DIX2_XENTR Four and a half LIM domains 1 (Silurana tropicalis) 296 92.00% Fhl1 ARP31902_P050 Q66KN8_XENLA MGC85575 protein Xenopus laevis (African clawed frog) 280 91.00% Fhl1 ARP31902_P050 Q6DCU0_XENLA MGC80746 protein Xenopus laevis (African clawed frog) 280 83.00% Homeobox protein OTX2‐B (xOTX2‐B) (Orthodenticle 2‐B) (Orthodenticle‐A‐like ARP32440_P050 OTX2B_XENLA protein B) Xenopus laevis (African clawed frog) 289 100.00% Homeobox protein OTX2‐A (xOTX2‐A) (Orthodenticle 2‐A) (Orthodenticle‐A‐like ARP32440_P050 OTX2A_XENLA protein A) Xenopus laevis (African clawed frog) 288 91.00% Xenopus tropicalis (Western clawed frog) ARP32440_P050 B1H3B9_XENTR Cone‐rod homeobox (Silurana tropicalis) 290 84.00% Homeobox protein otx5 (Orthodenticle Xenopus tropicalis (Western clawed frog) ARP32440_P050 OTX5_XENTR homolog 5) (Silurana tropicalis) 290 84.00% Homeobox protein otx5‐B (Orthodenticle ARP32440_P050 OTX5B_XENLA homolog 5‐B) (XOtx5b) Xenopus laevis (African clawed frog) 290 84.00% Homeobox protein otx5‐A (Orthodenticle ARP32440_P050 OTX5A_XENLA homolog 5‐A) (Xotx5) Xenopus laevis (African clawed frog) 290 84.00% Xenopus tropicalis (Western clawed frog) ARP32440_P050 OTX2_XENTR Homeobox protein OTX2 (Orthodenticle 2) (Silurana tropicalis) 289 91.00%

ORF Names:DKEY‐109M21.1‐001 EMBL CAX12069.1OrganismDanio rerio (Zebrafish) (Brachydanio rerio) ARP42925_P050 Q2TAS0_XENLA MGC130982 protein Xenopus laevis (African clawed frog) 590 92.00% Xenopus tropicalis (Western clawed frog) MAB21L1 ARP54782_P050 B1H177_XENTR Putative uncharacterized protein MGC145860 (Silurana tropicalis) 359 100.00% Xenopus tropicalis (Western clawed frog) MAB21L1 ARP54782_P050 MB211_XENTR Protein mab‐21‐like 1 (Silurana tropicalis) 359 100.00% MAB21L1 ARP54782_P050 MB211_XENLA Protein mab‐21‐like 1 Xenopus laevis (African clawed frog) 359 100.00% Xenopus tropicalis (Western clawed frog) MAB21L1 ARP54782_P050 MB212_XENTR Protein mab‐21‐like 2 (Silurana tropicalis) 359 84.00% MAB21L1 ARP54782_P050 M212B_XENLA Protein mab‐21‐like 2‐B Xenopus laevis (African clawed frog) 359 84.00% Protein mab‐21‐like 2‐A (XMab21l2) (Xmab‐ MAB21L1 ARP54782_P050 M212A_XENLA 21) Xenopus laevis (African clawed frog) 359 84.00% MYL1 ARP57712_P050 Q90ZP1_XENLA light chain 1av Xenopus laevis (African clawed frog) 190 84.00% Xenopus tropicalis (Western clawed frog) MYL1 ARP57712_P050 B2GU22_XENTR LOC100158490 protein (Silurana tropicalis) 164 78.00% LOC100124786 protein (Putative Xenopus tropicalis (Western clawed frog) MYL1 ARP57712_P050 A4IH22_XENTR uncharacterized protein LOC100124786) (Silurana tropicalis) 190 76.00% ARP45837_P050 Q7ZTL5_XENLA Cct8‐prov protein Xenopus laevis (African clawed frog) 546 85.00% ARP45837_P050 Q4QR49_XENLA Putative uncharacterized protein Xenopus laevis (African clawed frog) 548 85.00% Xenopus tropicalis (Western clawed frog) ARP45837_P050 Q28EG6_XENTR Chaperonin containing TCP1, subunit 8 (Theta) (Silurana tropicalis) 548 85.00% hnrnpr ARP40641_T100 Q6NS22_XENLA MGC78820 protein Xenopus laevis (African clawed frog) 624 100.00% Xenopus tropicalis (Western clawed frog) hnrnpr ARP40641_T100 B1WBI4_XENTR Syncrip protein (Fragment) (Silurana tropicalis) 638 100.00% Heterogeneous nuclear ribonucleoprotein R Xenopus tropicalis (Western clawed frog) hnrnpr ARP40641_T100 Q28BX1_XENTR (Fragment) (Silurana tropicalis) 535 84.00% hnrnpr ARP40641_T100 B1WBC3_XENLA LOC100158425 protein Xenopus laevis (African clawed frog) 511 84.00% Cxxc1 ARP32621_P050 Q6INJ5_XENLA MGC82437 protein Xenopus laevis (African clawed frog) 576 76.00% Xenopus tropicalis (Western clawed frog) Cxxc1 ARP32621_P050 Q4QQR2_XENTR Cxxc1‐prov protein (Fragment) (Silurana tropicalis) 578 76.00% Xenopus tropicalis (Western clawed frog) Cxxc1 ARP32621_P050 Q28BL1_XENTR CXXC finger 1 (PHD domain) (Fragment) (Silurana tropicalis) 597 76.00%

DNA replication licensing factor mcm4 Xenopus tropicalis (Western clawed frog) ARP36649_T100 MCM4_XENTR (Minichromosome maintenance protein 4) (Silurana tropicalis) 863 78.00% DNA replication licensing factor mcm4‐B (CDC21 homolog‐B) (Minichromosome maintenance protein 4‐B) (xMCM4‐B) (P1‐ ARP36649_T100 MCM4B_XENLA CDC21‐B) Xenopus laevis (African clawed frog) 863 76.00% DNA replication licensing factor mcm4‐A (CDC21 homolog‐A) (Minichromosome maintenance protein 4‐A) (xMCM4‐A) (P1‐ ARP36649_T100 MCM4A_XENLA CDC21‐A) (p98) Xenopus laevis (African clawed frog) 858 76.00% ORF Names:PPSIR1_32759 EMBL EDM74134.1OrganismPlesiocystis pacifica SIR‐1 ARP48289_P050 Q7ZTL1_XENLA Acaa2‐prov protein Xenopus laevis (African clawed frog) 397 92.00% ORF Names:PPSIR1_32759 EMBL EDM74134.1OrganismPlesiocystis Xenopus tropicalis (Western clawed frog) pacifica SIR‐1 ARP48289_P050 Q0VGV6_XENTR Putative uncharacterized protein MGC89951 (Silurana tropicalis) 358 92.00% Xenopus tropicalis (Western clawed frog) Tcfap2c ARP33433_P050 Q9PUL8_XENTR Transcription factor AP‐2 (Fragment) (Silurana tropicalis) 430 100.00% Tcfap2c ARP33433_P050 Q91867_XENLA Transcription factor Xenopus laevis (African clawed frog) 425 100.00% Tcfap2c ARP33433_P050 Q6NTV4_XENLA Tfap2a‐a protein Xenopus laevis (African clawed frog) 407 100.00% Tcfap2c ARP33433_P050 Q6NTJ1_XENLA MGC68493 protein Xenopus laevis (African clawed frog) 442 100.00% Tcfap2c ARP33433_P050 Q63ZP3_XENLA Tcfap2a protein Xenopus laevis (African clawed frog) 433 100.00%

Transcription factor AP‐2 gamma (Activating Xenopus tropicalis (Western clawed frog) Tcfap2c ARP33433_P050 Q5XGF5_XENTR enhancer binding protein 2 gamma) (Silurana tropicalis) 442 100.00%

Transcription factor AP‐2 gamma (Activating Xenopus tropicalis (Western clawed frog) Tcfap2c ARP33433_P050 Q28F74_XENTR enhancer binding protein 2 gamma) (Silurana tropicalis) 444 100.00%

Transcription factor AP‐2 alpha (Activating Xenopus tropicalis (Western clawed frog) Tcfap2c ARP33433_P050 Q28EF8_XENTR enhancer binding protein 2 alpha) (Silurana tropicalis) 430 100.00%

Transcription factor AP‐2 alpha (Activating Xenopus tropicalis (Western clawed frog) Tcfap2c ARP33433_P050 Q28EF6_XENTR enhancer binding protein 2 alpha) (Silurana tropicalis) 436 100.00% Xenopus tropicalis (Western clawed frog) Tcfap2c ARP33433_P050 A4IHV0_XENTR Tfap2a protein (Silurana tropicalis) 428 100.00% Tcfap2c ARP33433_P050 Q66J14_XENLA MGC83414 protein Xenopus laevis (African clawed frog) 440 92.00%

Transcription factor AP‐2 beta (Activating Xenopus tropicalis (Western clawed frog) Tcfap2c ARP33433_P050 Q28C75_XENTR enhancer binding protein 2 beta) (Silurana tropicalis) 441 92.00% Tcfap2c ARP33433_P050 Q6PB21_XENLA MGC68493 protein Xenopus laevis (African clawed frog) 399 92.00% Xenopus tropicalis (Western clawed frog) Tcfap2c ARP33433_P050 B3DL96_XENTR Tfap2e protein (Silurana tropicalis) 434 85.00% Transcription factor AP‐2‐epsilon (AP‐2‐ Tcfap2c ARP33433_P050 AP2E_XENLA epsilon) Xenopus laevis (African clawed frog) 434 85.00% ORF Names:ACLA_081010 EMBL EAW06417.1OrganismAspergillus clavatus ARP56133_P050 Q7SZC0_XENLA Rpl30‐prov protein Xenopus laevis (African clawed frog) 116 100.00% ORF Names:ACLA_081010 EMBL EAW06417.1OrganismAspergillus clavatus ARP56133_P050 Q6GNF2_XENLA MGC82844 protein Xenopus laevis (African clawed frog) 116 100.00% ORF Names:ACLA_081010 EMBL EAW06417.1OrganismAspergillus Xenopus tropicalis (Western clawed frog) clavatus ARP56133_P050 Q6DEP8_XENTR MGC89963 protein (Silurana tropicalis) 116 100.00% ORF Names:ACLA_081010 EMBL EAW06417.1OrganismAspergillus clavatus ARP56133_P050 B2L4E3_XENBO Ribosomal protein L30 (Fragment) Xenopus borealis (Kenyan clawed frog) 53 100.00% NUMA ARP50532_P050 P70012_XENLA Nuclear/mitotic apparatus protein Xenopus laevis (African clawed frog) 2253 85.00%

ORF Names:zgc:158291 ZFIN ZDB‐GENE‐ 061215‐70OrganismDanio rerio Class IV POU‐homeodomain protein (Zebrafish) (Brachydanio rerio) ARP33065_T100 Q9DG32_XENLA (Fragment) Xenopus laevis (African clawed frog) 358 100.00%

ORF Names:zgc:158291 ZFIN ZDB‐GENE‐ 061215‐70OrganismDanio rerio (Zebrafish) (Brachydanio rerio) ARP33065_T100 Q9DG50_XENLA Class IV POU‐homeodomain protein Xenopus laevis (African clawed frog) 343 92.00%

ORF Names:zgc:158291 ZFIN ZDB‐GENE‐ 061215‐70OrganismDanio rerio Xenopus tropicalis (Western clawed frog) (Zebrafish) (Brachydanio rerio) ARP33065_T100 A4IGJ4_XENTR Pou4f1.2 protein (Silurana tropicalis) 340 92.00% Xenopus tropicalis (Western clawed frog) cbr‐unc‐23 ARP42177_T100 Q6DIQ9_XENTR BCL2‐associated athanogene 2 (Silurana tropicalis) 213 85.00% Xenopus tropicalis (Western clawed frog) ARP32866_P050 A0PJP5_XENTR Dlx1 protein (Silurana tropicalis) 251 85.00%

ORF Names:CH211‐51O12.3‐001 EMBL CAP09362.1OrganismDanio rerio (Zebrafish) (Brachydanio rerio) ARP35399_T100 Q68EY1_XENLA LOC446288 protein (Fragment) Xenopus laevis (African clawed frog) 546 92.00% ORF Names:GSPATT00001142001 EMBL CAK74940.1OrganismParamecium tetraurelia ARP33126_T100 Q7SZ88_XENLA Ube2n‐prov protein Xenopus laevis (African clawed frog) 152 100.00% ORF Names:GSPATT00001142001 EMBL Ubiquitin‐conjugating enzyme E2N (UBC13 CAK74940.1OrganismParamecium homolog) (Ubiquitin‐conjugating enzyme E2N Xenopus tropicalis (Western clawed frog) tetraurelia ARP33126_T100 Q6P349_XENTR (UBC13 homolog, yeast)) (Silurana tropicalis) 152 100.00% P100882_P050 B7ZS18_XENLA XLFli protein Xenopus laevis (African clawed frog) 453 85.00% Xenopus tropicalis (Western clawed frog) P100882_P050 A4IHU3_XENTR Fli1 protein (Silurana tropicalis) 459 85.00% Retroviral integration site protein Fli‐1 P100882_P050 FLI1_XENLA homolog Xenopus laevis (African clawed frog) 453 85.00% P100882_P050 Q9W700_XENLA Erg protein Xenopus laevis (African clawed frog) 485 85.00% P100882_P050 Q9W6Z9_XENLA Erg protein Xenopus laevis (African clawed frog) 456 85.00% P100882_P050 Q6GNZ9_XENLA MGC80765 protein Xenopus laevis (African clawed frog) 485 85.00% P100882_P050 B7ZSD3_XENLA Erg gene (Erg_E) Xenopus laevis (African clawed frog) 456 85.00% Xenopus tropicalis (Western clawed frog) P100882_P050 B4F6M4_XENTR Putative uncharacterized protein (Silurana tropicalis) 458 85.00% Xenopus tropicalis (Western clawed frog) krt15 ARP42240_P050 B2GUG8_XENTR LOC100158585 protein (Silurana tropicalis) 465 92.00% krt15 ARP42240_P050 Q8AV12_XENLA Adult keratin XAK‐C Xenopus laevis (African clawed frog) 491 85.00% krt15 ARP42240_P050 Q642P1_XENLA LOC446967 protein (Fragment) Xenopus laevis (African clawed frog) 467 85.00% krt15 ARP42240_P050 B7ZRD4_XENLA Ak‐c‐A protein Xenopus laevis (African clawed frog) 492 85.00% Xenopus tropicalis (Western clawed frog) krt15 ARP42240_P050 B0BMI8_XENTR Krt12 protein (Silurana tropicalis) 450 85.00% Xenopus tropicalis (Western clawed frog) krt15 ARP42240_P050 B0BMH1_XENTR Krt12 protein (Silurana tropicalis) 450 85.00% krt15 ARP42240_P050 K1C3_XENLA Keratin, type I cytoskeletal 47 kDa (Fragment) Xenopus laevis (African clawed frog) 280 85.00% krt15 ARP42240_P050 Q6DDD5_XENLA Krt16‐prov protein Xenopus laevis (African clawed frog) 423 85.00% krt15 ARP42240_P050 E3WF12_XENLA Fin and gill‐specific type‐1 keratin Xenopus laevis (African clawed frog) 424 85.00% krt15 ARP42240_P050 Q505L4_XENLA LOC397864 protein Xenopus laevis (African clawed frog) 483 84.00% Keratin‐3, type I cytoskeletal 51 kDa (51 kDa krt15 ARP42240_P050 K1C0_XENLA cytokeratin) Xenopus laevis (African clawed frog) 486 84.00% krt15 ARP42240_P050 Q7ZY83_XENLA LOC398464 protein (Fragment) Xenopus laevis (African clawed frog) 469 78.00% krt15 ARP42240_P050 Q4QR57_XENLA LOC398464 protein Xenopus laevis (African clawed frog) 454 78.00% krt15 ARP42240_P050 K1C4_XENLA Keratin, type I cytoskeletal 47 kDa Xenopus laevis (African clawed frog) 419 78.00% Xenopus tropicalis (Western clawed frog) krt15 ARP42240_P050 Q6P7K6_XENTR Keratin 19 (Silurana tropicalis) 412 78.00% krt15 ARP42240_P050 Q6IRP5_XENLA MGC83069 protein Xenopus laevis (African clawed frog) 412 78.00% Xenopus tropicalis (Western clawed frog) krt15 ARP42240_P050 Q28IM9_XENTR Keratin 12 (Silurana tropicalis) 375 78.00% Xenopus tropicalis (Western clawed frog) krt15 ARP42240_P050 Q28FN7_XENTR Keratin 19 (Silurana tropicalis) 307 78.00% krt15 ARP42240_P050 Q05AX6_XENLA Krt19 protein Xenopus laevis (African clawed frog) 443 78.00% Xenopus tropicalis (Western clawed frog) krt15 ARP42240_P050 B3DM07_XENTR Putative uncharacterized protein (Silurana tropicalis) 436 78.00% Xenopus tropicalis (Western clawed frog) krt15 ARP42240_P050 B0BMI0_XENTR LOC100145042 protein (Silurana tropicalis) 423 78.00% Xenopus tropicalis (Western clawed frog) krt15 ARP42240_P050 B0BMG5_XENTR Putative uncharacterized protein LOC549413 (Silurana tropicalis) 431 78.00% krt15 ARP42240_P050 Q7ZYN9_XENLA MGC53311 protein Xenopus laevis (African clawed frog) 375 76.00% krt15 ARP42240_P050 Q6DKC7_XENLA MGC84118 protein Xenopus laevis (African clawed frog) 458 78.00% krt15 ARP42240_P050 Q5XGU0_XENLA LOC495266 protein Xenopus laevis (African clawed frog) 452 78.00% krt15 ARP42240_P050 Q7T0X6_XENLA MGC68905 protein Xenopus laevis (African clawed frog) 437 78.00% krt15 ARP42240_P050 Q2VPN9_XENLA MGC68905 protein Xenopus laevis (African clawed frog) 437 78.00% krt15 ARP42240_P050 K1C1_XENLA Keratin, type I cytoskeletal 47 kDa Xenopus laevis (African clawed frog) 429 78.00% krt15 ARP42240_P050 Q0X0A4_XENLA Keratin Xenopus laevis (African clawed frog) 441 76.00% krt15 ARP42240_P050 A2VDC4_XENLA LOC779065 protein Xenopus laevis (African clawed frog) 447 76.00% krt15 ARP42240_P050 Q98UJ2_XENLA Adult keratin XAK‐A Xenopus laevis (African clawed frog) 414 83.00% krt15 ARP42240_P050 B7ZSA0_XENLA Adult keratin XAK‐A Xenopus laevis (African clawed frog) 414 83.00%

Sodium‐dependent phosphate transporter 1‐A ARP43905_P050 S20AA_XENLA (Solute carrier family 20 member 1‐A) Xenopus laevis (African clawed frog) 685 78.00% ORF Names:LbrM35_V2.6550 EMBL CAM44408.1OrganismLeishmania braziliensis ARP38065_T100 Q6DDN3_XENLA Trim23‐prov protein Xenopus laevis (African clawed frog) 588 85.00%

ORF Names:zgc:101130 ZFIN ZDB‐GENE‐ 040801‐72OrganismDanio rerio Xenopus tropicalis (Western clawed frog) (Zebrafish) (Brachydanio rerio) ARP50970_P050 A9UM96_XENTR LOC100135281 protein (Silurana tropicalis) 282 83.00%

ORF Names:zgc:101130 ZFIN ZDB‐GENE‐ 040801‐72OrganismDanio rerio (Zebrafish) (Brachydanio rerio) ARP50970_P050 Q9IB60_XENLA Smad interaction protein 1 Xenopus laevis (African clawed frog) 1214 91.00%

ORF Names:zgc:101130 ZFIN ZDB‐GENE‐ 040801‐72OrganismDanio rerio (Zebrafish) (Brachydanio rerio) ARP50970_P050 Q9I8P1_XENLA Smad‐interacting protein 1 Xenopus laevis (African clawed frog) 1213 91.00%

ORF Names:zgc:101130 ZFIN ZDB‐GENE‐ 040801‐72OrganismDanio rerio (Zebrafish) (Brachydanio rerio) ARP50970_P050 Q6GNA9_XENLA MGC82910 protein Xenopus laevis (African clawed frog) 1093 91.00%

ORF Names:zgc:101130 ZFIN ZDB‐GENE‐ 040801‐72OrganismDanio rerio (Zebrafish) (Brachydanio rerio) ARP50970_P050 Q6DCT1_XENLA Bcl6‐prov protein Xenopus laevis (African clawed frog) 701 85.00%

ORF Names:zgc:101130 ZFIN ZDB‐GENE‐ 040801‐72OrganismDanio rerio (Zebrafish) (Brachydanio rerio) ARP50970_P050 Q5U4Y1_XENLA LOC495412 protein Xenopus laevis (African clawed frog) 701 85.00% ORF Names:zgc:101130 ZFIN ZDB‐GENE‐ 040801‐72OrganismDanio rerio (Zebrafish) (Brachydanio rerio) ARP50970_P050 Q5U4S2_XENLA Sip1 protein Xenopus laevis (African clawed frog) 1214 91.00%

ORF Names:zgc:101130 ZFIN ZDB‐GENE‐ 040801‐72OrganismDanio rerio Xenopus tropicalis (Western clawed frog) (Zebrafish) (Brachydanio rerio) ARP50970_P050 Q5EB46_XENTR Zinc finger E‐box binding homeobox 1 (Silurana tropicalis) 1099 91.00%

ORF Names:zgc:101130 ZFIN ZDB‐GENE‐ 040801‐72OrganismDanio rerio (Zebrafish) (Brachydanio rerio) ARP50970_P050 Q1A551_XENLA Zinc finger homeobox 1a Xenopus laevis (African clawed frog) 1091 91.00%

ORF Names:zgc:101130 ZFIN ZDB‐GENE‐ 040801‐72OrganismDanio rerio Xenopus tropicalis (Western clawed frog) (Zebrafish) (Brachydanio rerio) ARP50970_P050 B4F6S1_XENTR Putative uncharacterized protein (Silurana tropicalis) 337 78.00%

ORF Names:zgc:101130 ZFIN ZDB‐GENE‐ 040801‐72OrganismDanio rerio Xenopus tropicalis (Western clawed frog) (Zebrafish) (Brachydanio rerio) ARP50970_P050 B1WB42_XENTR Zbtb41 protein (Silurana tropicalis) 848 91.00%

ORF Names:zgc:101130 ZFIN ZDB‐GENE‐ 040801‐72OrganismDanio rerio Xenopus tropicalis (Western clawed frog) (Zebrafish) (Brachydanio rerio) ARP50970_P050 B1H333_XENTR Bcl6 protein (Silurana tropicalis) 702 85.00%

ORF Names:zgc:101130 ZFIN ZDB‐GENE‐ 040801‐72OrganismDanio rerio Xenopus tropicalis (Western clawed frog) (Zebrafish) (Brachydanio rerio) ARP50970_P050 B1H2H7_XENTR LOC100145431 protein (Silurana tropicalis) 346 78.00%

ORF Names:GSTENG00000963001 EMBL CAF87915.1OrganismTetraodon nigroviridis (Green puffer) ARP36744_P050 A8WH49_XENLA LOC100127255 protein (Fragment) Xenopus laevis (African clawed frog) 498 100.00% ARP31776_P050 Q6IR88_XENLA MGC81400 protein Xenopus laevis (African clawed frog) 412 76.00% ARP31776_P050 Q63ZR8_XENLA LOC494745 protein Xenopus laevis (African clawed frog) 412 76.00%

Protoheme IX farnesyltransferase, cox10 ARP45079_P050 Q0IH15_XENLA mitochondrial (EC 2.5.1.‐) (Heme O synthase) Xenopus laevis (African clawed frog) 419 100.00% Xenopus tropicalis (Western clawed frog) cox10 ARP45079_P050 B0BMH3_XENTR LOC100145039 protein (Silurana tropicalis) 418 100.00% Xenopus tropicalis (Western clawed frog) tmtc4 ARP45028_P050 B2GUG9_XENTR LOC100158586 protein (Silurana tropicalis) 738 92.00% Xenopus tropicalis (Western clawed frog) ADAM13 ARP49780_P050 Q27JK7_XENTR ADAM12 (Silurana tropicalis) 925 85.00% Xenopus tropicalis (Western clawed frog) ADAM13 ARP49780_P050 Q27JK5_XENTR ADAM19 (Silurana tropicalis) 911 84.00% ADAM13 ARP49780_P050 B3VML7_XENLA ADAM19 Xenopus laevis (African clawed frog) 887 84.00% Xenopus tropicalis (Western clawed frog) ADAM13 ARP49780_P050 Q27JK6_XENTR ADAM13 (Silurana tropicalis) 911 84.00% ADAM13 ARP49780_P050 O12960_XENLA ADAM 13 Xenopus laevis (African clawed frog) 914 84.00%

ADAM13 ARP49780_P050 B7ZQX1_XENLA A disintegrin and metalloprotease domain 13 Xenopus laevis (African clawed frog) 914 84.00%

ADAM13 ARP49780_P050 B7ZQW9_XENLA A disintegrin and metalloprotease domain 13 Xenopus laevis (African clawed frog) 914 84.00% Gla ARP54296_P050 Q6GR44_XENLA Nagaa protein Xenopus laevis (African clawed frog) 400 85.00% Gla ARP54296_P050 Q6GQ17_XENLA Nagab protein (Fragment) Xenopus laevis (African clawed frog) 431 85.00% Xenopus tropicalis (Western clawed frog) Gla ARP54296_P050 Q0P4I8_XENTR Naga protein (Fragment) (Silurana tropicalis) 432 85.00% Xenopus tropicalis (Western clawed frog) Gla ARP54296_P050 A8WGV2_XENTR Naga protein (Silurana tropicalis) 403 85.00% Gla ARP54296_P050 Q3KQ87_XENLA MGC130872 protein Xenopus laevis (African clawed frog) 408 78.00% Xenopus tropicalis (Western clawed frog) Gla ARP54296_P050 B1WBF4_XENTR LOC100145767 protein (Silurana tropicalis) 408 78.00% Xenopus tropicalis (Western clawed frog) ARP46129_P050 Q28CF2_XENTR Serine hydroxymethyltransferase 1 (Soluble) (Silurana tropicalis) 485 84.00% ARP46129_P050 Q6AXB3_XENLA MGC79128 protein Xenopus laevis (African clawed frog) 496 78.00% Xenopus tropicalis (Western clawed frog) ARP46129_P050 Q68EQ3_XENTR Shmt2 protein (Silurana tropicalis) 496 78.00% ZEB1 ARP32422_P050 Q6GNA9_XENLA MGC82910 protein Xenopus laevis (African clawed frog) 1093 92.00% Xenopus tropicalis (Western clawed frog) ZEB1 ARP32422_P050 Q5EB46_XENTR Zinc finger E‐box binding homeobox 1 (Silurana tropicalis) 1099 92.00% ZEB1 ARP32422_P050 Q1A551_XENLA Zinc finger homeobox 1a Xenopus laevis (African clawed frog) 1091 76.00% mumArgII ARP45671_P050 Q7ZYM1_XENLA Arg1 protein (Arg1‐prov protein) Xenopus laevis (African clawed frog) 323 92.00% Xenopus tropicalis (Western clawed frog) mumArgII ARP45671_P050 Q6DIU5_XENTR , liver (Silurana tropicalis) 323 92.00% Arginase‐1 (EC 3.5.3.1) (Arginase, hepatic) mumArgII ARP45671_P050 ARGI1_XENLA (Type I arginase) Xenopus laevis (African clawed frog) 316 92.00% Gamma‐aminobutyric acid receptor‐ associated protein‐like 1 (GABA(A) receptor‐ Xenopus tropicalis (Western clawed frog) ARP55399_P050 GBRL1_XENTR associated protein‐like 1) (Silurana tropicalis) 117 100.00% Gamma‐aminobutyric acid receptor‐ associated protein‐like 1 (GABA(A) receptor‐ ARP55399_P050 GBRL1_XENLA associated protein‐like 1) Xenopus laevis (African clawed frog) 117 100.00% ARP55399_P050 Q6NUG7_XENLA MGC78908 protein Xenopus laevis (African clawed frog) 117 78.00% Xenopus tropicalis (Western clawed frog) ARP55399_P050 Q5PPQ1_XENTR GABA(A) receptor‐associated protein like 1 (Silurana tropicalis) 117 78.00% ORF Names:MGG_00540 EMBL EDK02838.1OrganismMagnaporthe oryzae (strain 70‐15 / FGSC 8958) (Rice Xenopus tropicalis (Western clawed frog) fungus) (Pyricularia oryzae) ARP42751_T100 B1H0X8_XENTR LOC100145275 protein (Silurana tropicalis) 406 100.00% Xenopus tropicalis (Western clawed frog) gopc ARP56215_P050 B0JZF4_XENTR LOC100145196 protein (Silurana tropicalis) 326 84.00% ARP33627_P050 Q6GNW1_XENLA MGC80834 protein Xenopus laevis (African clawed frog) 216 78.00% Claudin 5 (Transmembrane protein deleted in Xenopus tropicalis (Western clawed frog) ARP33627_P050 Q6DIW1_XENTR velocardiofacial syndrome) (Silurana tropicalis) 216 78.00% ARP33627_P050 Q6PA22_XENLA MGC68716 protein Xenopus laevis (African clawed frog) 216 78.00% Hibadh ARP53111_P050 Q6NRB2_XENLA MGC84587 protein Xenopus laevis (African clawed frog) 328 100.00% Hibadh ARP53111_P050 Q5XGV0_XENLA LOC495134 protein Xenopus laevis (African clawed frog) 328 100.00% Xenopus tropicalis (Western clawed frog) Hibadh ARP53111_P050 Q5BKJ0_XENTR MGC108315 protein (Silurana tropicalis) 328 100.00% HIP2 ARP43049_P050 Q8AVM8_XENLA Ube2k protein Xenopus laevis (African clawed frog) 200 92.00% Ubiquitin‐conjugating enzyme E2K (UBC1 Xenopus tropicalis (Western clawed frog) HIP2 ARP43049_P050 Q6GL28_XENTR homolog) (Silurana tropicalis) 200 92.00% Xenopus tropicalis (Western clawed frog) HIP2 ARP43049_P050 B0JZQ9_XENTR LOC100145219 protein (Silurana tropicalis) 200 84.00% Xenopus tropicalis (Western clawed frog) ARP36465_T100 Q6P1S5_XENTR DEAD (Asp‐Glu‐Ala‐Asp) box polypeptide 49 (Silurana tropicalis) 479 100.00% ARP36465_T100 Q800A3_XENLA Ddx49‐A‐prov protein (Fragment) Xenopus laevis (African clawed frog) 482 92.00% ARP36465_T100 Q6INF8_XENLA Ddx49‐A‐prov protein (Fragment) Xenopus laevis (African clawed frog) 429 92.00% brd2a ARP38940_P050 A1L1G8_XENLA LOC100036838 protein Xenopus laevis (African clawed frog) 783 92.00% Xenopus tropicalis (Western clawed frog) brd2a ARP38940_P050 B5DE90_XENTR Brd2 protein (Silurana tropicalis) 758 85.00% Xenopus tropicalis (Western clawed frog) RING1 ARP34290_T100 B1WAN7_XENTR Ring finger protein 2 (Silurana tropicalis) 336 100.00% LOC100127274 protein (Putative RING1 ARP34290_T100 A9JSS1_XENLA uncharacterized protein LOC100127274) Xenopus laevis (African clawed frog) 336 100.00% Xenopus tropicalis (Western clawed frog) RING1 ARP34290_T100 A4IGP4_XENTR Ring1 protein (Silurana tropicalis) 344 76.00% E3 ubiquitin‐protein ligase RING2‐B (EC 6.3.2.‐ ) (RING finger protein 1B‐B) (RING1b‐B) (RING RING1 ARP34290_T100 RNG2B_XENLA finger protein 2‐B) Xenopus laevis (African clawed frog) 343 76.00% E3 ubiquitin‐protein ligase RING2‐A (EC 6.3.2.‐ ) (RING finger protein 1B‐A) (RING1b‐A) (RING RING1 ARP34290_T100 RNG2A_XENLA finger protein 2‐A) Xenopus laevis (African clawed frog) 344 76.00% ARP46165_T100 Q8JHF9_XENLA Stress‐induced phosphoprotein STI1 Xenopus laevis (African clawed frog) 543 84.00% ARP46165_T100 Q7ZWU1_XENLA Stip1‐prov protein Xenopus laevis (African clawed frog) 543 84.00% ARP46165_T100 Q6DCK0_XENLA Stip1‐prov protein Xenopus laevis (African clawed frog) 430 84.00% Stress‐induced‐phosphoprotein 1 Xenopus tropicalis (Western clawed frog) ARP46165_T100 Q6P302_XENTR (Hsp70/Hsp90‐organizing protein) (Silurana tropicalis) 543 84.00% Xenopus tropicalis (Western clawed frog) Dlg3 ARP43694_P050 DLG1_XENTR Isoform 2 (Silurana tropicalis) 686 92.00% Xenopus tropicalis (Western clawed frog) Dlg3 ARP43694_P050 DLG1_XENTR Disks large homolog 1 (Silurana tropicalis) 927 92.00% Xenopus tropicalis (Western clawed frog) Dlg3 ARP43694_P050 Q0IHR6_XENTR Dlgh4 protein (Fragment) (Silurana tropicalis) 774 85.00% Xenopus tropicalis (Western clawed frog) Dlg3 ARP43694_P050 A9JRI4_XENTR Dlgh4 protein (Fragment) (Silurana tropicalis) 782 85.00% Xenopus tropicalis (Western clawed frog) Dlg3 ARP43694_P050 A4IHB8_XENTR Dlgh4 protein (Fragment) (Silurana tropicalis) 776 85.00% ergic3 ARP47209_P050 A1L2K3_XENLA LOC100036873 protein Xenopus laevis (African clawed frog) 384 84.00% ‐Golgi intermediate Xenopus tropicalis (Western clawed frog) ergic3 ARP47209_P050 ERGI3_XENTR compartment protein 3 (Silurana tropicalis) 384 84.00% Endoplasmic reticulum‐Golgi intermediate ergic3 ARP47209_P050 ERGI3_XENLA compartment protein 3 Xenopus laevis (African clawed frog) 389 84.00% Xenopus tropicalis (Western clawed frog) LOC100125167 ARP34293_P050 A4QNJ1_XENTR LOC100125167 protein (Fragment) (Silurana tropicalis) 299 84.00% LOC100125167 ARP34293_P050 Q3KQ29_XENLA MGC131058 protein Xenopus laevis (African clawed frog) 332 84.00% ORF Names:zgc:165608 EMBL AAI42900.1 ZFIN ZDB‐GENE‐070615‐ 36OrganismDanio rerio (Zebrafish) (Brachydanio rerio) ARP49856_P050 TXD15_XENLA Thioredoxin domain‐containing protein 15 Xenopus laevis (African clawed frog) 342 85.00% Xenopus tropicalis (Western clawed frog) ARP34087_P050 A4IGR1_XENTR LOC100038271 protein (Silurana tropicalis) 621 100.00% Xenopus tropicalis (Western clawed frog) ARP38966_T100 A4IIF7_XENTR LOC100124994 protein (Silurana tropicalis) 649 92.00% CDGSH iron‐sulfur domain‐containing protein Xenopus tropicalis (Western clawed frog) cisd2a ARP44552_P050 CISD2_XENTR 2 (Silurana tropicalis) 135 85.00% CDGSH iron‐sulfur domain‐containing protein cisd2a ARP44552_P050 CID2A_XENLA 2A Xenopus laevis (African clawed frog) 135 85.00% CDGSH iron‐sulfur domain‐containing protein cisd2a ARP44552_P050 CID2B_XENLA 2B Xenopus laevis (African clawed frog) 135 85.00%

ORF Names:v1g171497OrganismNematostel la vectensis (Starlet sea anemone) ARP41191_P050 Q7ZYH8_XENLA LOC398475 protein (Fragment) Xenopus laevis (African clawed frog) 241 100.00%

ORF Names:v1g171497OrganismNematostel la vectensis (Starlet sea anemone) ARP41191_P050 Q6GLM7_XENLA MGC84702 protein Xenopus laevis (African clawed frog) 228 100.00% ORF Names:v1g171497OrganismNematostel la vectensis (Starlet sea anemone) ARP41191_P050 Q5PPT6_XENLA LOC398475 protein Xenopus laevis (African clawed frog) 214 100.00%

ORF Names:v1g171497OrganismNematostel Xenopus tropicalis (Western clawed frog) la vectensis (Starlet sea anemone) ARP41191_P050 Q5FVX8_XENTR MGC108344 protein (Silurana tropicalis) 214 100.00%

ORF Names:v1g171497OrganismNematostel Hypothetical LOC496564 (Transmembrane Xenopus tropicalis (Western clawed frog) la vectensis (Starlet sea anemone) ARP41191_P050 Q5XGA7_XENTR emp24 protein tra) (Silurana tropicalis) 217 84.00%

ORF Names:v1g171497OrganismNematostel la vectensis (Starlet sea anemone) ARP41191_P050 Q63ZK2_XENLA LOC494789 protein Xenopus laevis (African clawed frog) 142 84.00% ORF Names:SIAM614_26331 EMBL EAV41719.1OrganismLabrenzia aggregata IAM 12614 ARP55538_P050 CD022_XENLA Uncharacterized protein C4orf22 homolog Xenopus laevis (African clawed frog) 233 92.00% KLF7 ARP38430_P050 Q7SY91_XENLA Klf7‐prov protein Xenopus laevis (African clawed frog) 293 100.00% Xenopus tropicalis (Western clawed frog) KLF7 ARP38430_P050 Q6DIM6_XENTR Zinc finger protein 534 (Silurana tropicalis) 368 100.00% Xenopus tropicalis (Western clawed frog) KLF7 ARP38430_P050 Q28D29_XENTR protein (Kruppel‐like factor 4 (Gut)) (Silurana tropicalis) 407 100.00% Xenopus tropicalis (Western clawed frog) KLF7 ARP38430_P050 Q0IHT4_XENTR Kruppel‐like factor 7 (Ubiquitous) (Silurana tropicalis) 296 100.00% Xenopus tropicalis (Western clawed frog) KLF7 ARP38430_P050 A0JLZ3_XENTR Klf4 protein (Fragment) (Silurana tropicalis) 418 100.00% Kruppel‐like transcription factor neptune KLF7 ARP38430_P050 Q90XS5_XENLA (LOC398243 protein) Xenopus laevis (African clawed frog) 413 92.00% KLF7 ARP38430_P050 Q8QGW6_XENLA Blood island enriched kruppel like factor Xenopus laevis (African clawed frog) 413 92.00% Klf2 protein (Lung enriched kruppel like KLF7 ARP38430_P050 Q8QGW5_XENLA factor) Xenopus laevis (African clawed frog) 373 92.00% KLF7 ARP38430_P050 Q7ZXK7_XENLA Copeb‐prov protein Xenopus laevis (African clawed frog) 283 92.00% KLF7 ARP38430_P050 Q7T3J7_XENLA AP‐2 repressor Xenopus laevis (African clawed frog) 357 92.00% KLF7 ARP38430_P050 Q7SZU5_XENLA Biklf‐A protein Xenopus laevis (African clawed frog) 413 92.00% Xenopus tropicalis (Western clawed frog) KLF7 ARP38430_P050 Q68FA0_XENTR Copeb protein (Silurana tropicalis) 283 92.00% KLF7 ARP38430_P050 Q66KQ9_XENLA LOC446965 protein (Fragment) Xenopus laevis (African clawed frog) 278 92.00% KLF7 ARP38430_P050 Q2TAV3_XENLA Biklf‐A protein Xenopus laevis (African clawed frog) 392 92.00% Kruppel‐like factor 2 (Lung) (Novel kruppel‐ Xenopus tropicalis (Western clawed frog) KLF7 ARP38430_P050 Q28D19_XENTR like factor family protein) (Silurana tropicalis) 373 92.00% Xenopus tropicalis (Western clawed frog) KLF7 ARP38430_P050 Q28BQ7_XENTR Novel kruppel‐like factor family protein (Silurana tropicalis) 413 92.00% KLF7 ARP38430_P050 B7ZR90_XENLA AP‐2 repressor Xenopus laevis (African clawed frog) 357 92.00% Xenopus tropicalis (Western clawed frog) KLF7 ARP38430_P050 B1H3D6_XENTR Klf8 protein (Silurana tropicalis) 337 92.00% si:dkey‐98f17.2 ARP38862_P050 Q6NRT1_XENLA MGC81491 protein Xenopus laevis (African clawed frog) 778 100.00% Xenopus tropicalis (Western clawed frog) si:dkey‐98f17.2 ARP38862_P050 B2GUN2_XENTR LOC100158621 protein (Silurana tropicalis) 778 100.00% ORF Names:ACLA_045930 EMBL EAW10128.1OrganismAspergillus Ribonucleotide reductase subunit M1 clavatus ARP46030_T100 Q9DE56_XENLA (Fragment) Xenopus laevis (African clawed frog) 520 100.00% ORF Names:ACLA_045930 EMBL EAW10128.1OrganismAspergillus clavatus ARP46030_T100 Q7ZWQ0_XENLA RRM1 protein (Fragment) Xenopus laevis (African clawed frog) 760 100.00% ORF Names:ACLA_045930 EMBL EAW10128.1OrganismAspergillus clavatus ARP46030_T100 Q6GM88_XENLA RRM1 protein Xenopus laevis (African clawed frog) 797 100.00% ORF Names:ACLA_045930 EMBL EAW10128.1OrganismAspergillus Xenopus tropicalis (Western clawed frog) clavatus ARP46030_T100 B1WAW9_XENTR LOC100145720 protein (Silurana tropicalis) 797 100.00% Xenopus tropicalis (Western clawed frog) PAX3 ARP32446_T100 Q6DIG5_XENTR Paired box 3 (Silurana tropicalis) 254 78.00% PAX3 ARP32446_T100 PAX3B_XENLA Isoform 2 Xenopus laevis (African clawed frog) 459 78.00% Paired box protein Pax‐3 (Paired‐domain Xenopus tropicalis (Western clawed frog) PAX3 ARP32446_T100 PAX3_XENTR transcription factor Pax3) (Silurana tropicalis) 461 78.00%

Paired box protein Pax‐3‐B (xPax3‐B) (Paired‐ PAX3 ARP32446_T100 PAX3B_XENLA domain transcription factor Pax3‐B) Xenopus laevis (African clawed frog) 483 78.00% ARP39544_P050 Q6PA61_XENLA MGC68807 protein Xenopus laevis (African clawed frog) 492 92.00% Xenopus tropicalis (Western clawed frog) dido1 ARP39544_P050 B0JZV2_XENTR Putative uncharacterized protein (Fragment) (Silurana tropicalis) 1162 92.00% dido1 ARP39544_P050 Q63ZQ9_XENLA LOC494751 protein Xenopus laevis (African clawed frog) 2234 84.00%

ORF Names:CHLREDRAFT_174569 EMBL EDP01301.1OrganismChlamydomonas reinhardtii (Chlamydomonas smithii) ARP55747_P050 Q6IR65_XENLA LOC432094 protein (Fragment) Xenopus laevis (African clawed frog) 399 91.00%

ORF Names:CHLREDRAFT_174569 EMBL EDP01301.1OrganismChlamydomonas reinhardtii (Chlamydomonas smithii) ARP55747_P050 Q66IS5_XENLA MGC85240 protein Xenopus laevis (African clawed frog) 288 91.00% ORF Names:CHLREDRAFT_174569 EMBL EDP01301.1OrganismChlamydomonas Zinc binding , domain Xenopus tropicalis (Western clawed frog) reinhardtii (Chlamydomonas smithii) ARP55747_P050 Q5M7N3_XENTR containing 2 (Silurana tropicalis) 399 91.00%

ORF Names:CHLREDRAFT_174569 EMBL EDP01301.1OrganismChlamydomonas reinhardtii (Chlamydomonas smithii) ARP55747_P050 Q498I7_XENLA LOC432094 protein Xenopus laevis (African clawed frog) 401 91.00% ORF Lipoyl synthase, mitochondrial (EC 2.8.1.8) Names:ACLA_034510OrganismAspergill (Lipoate synthase) (LS) (Lip‐syn) (Lipoic acid us clavatus ARP48717_P050 LIAS_XENLA synthase) Xenopus laevis (African clawed frog) 372 100.00% ARP38096_T100 B7ZS18_XENLA XLFli protein Xenopus laevis (African clawed frog) 453 85.00% Xenopus tropicalis (Western clawed frog) fli1 ARP38096_T100 A4IHU3_XENTR Fli1 protein (Silurana tropicalis) 459 85.00% Retroviral integration site protein Fli‐1 fli1 ARP38096_T100 FLI1_XENLA homolog Xenopus laevis (African clawed frog) 453 85.00% Xenopus tropicalis (Western clawed frog) reep2 ARP49770_P050 A2RUV6_XENTR LOC100037847 protein (Silurana tropicalis) 266 78.00% reep2 ARP49770_P050 Q6P418_XENLA MGC68764 protein Xenopus laevis (African clawed frog) 263 83.00% Xenopus tropicalis (Western clawed frog) si:dkey‐251i10.1 ARP58528_P050 B0JZQ1_XENTR LOC100145214 protein (Silurana tropicalis) 298 92.00% Adenine nucleotide translocase (Slc25a5‐prov si:dkey‐251i10.1 ARP58528_P050 Q9I9M9_XENLA protein) Xenopus laevis (African clawed frog) 298 85.00% Adenine nucleotide translocase (OTTXETP00000012167) Xenopus tropicalis (Western clawed frog) si:dkey‐251i10.1 ARP58528_P050 Q6PBF5_XENTR (OTTXETP00000012168) (Silurana tropicalis) 298 85.00%

Solute carrier family 25 (Mitochondrial carrier; Xenopus tropicalis (Western clawed frog) si:dkey‐251i10.1 ARP58528_P050 Q6P7N0_XENTR adenine nucleotide translocator), member 4 (Silurana tropicalis) 298 85.00% Xenopus tropicalis (Western clawed frog) P100653_P050 Q6DF66_XENTR Activating transcription factor 5, gene 2 (Silurana tropicalis) 305 85.00% P100653_P050 Q6DCW2_XENLA Atf5‐prov protein Xenopus laevis (African clawed frog) 308 85.00% Xenopus tropicalis (Western clawed frog) P100653_P050 B0BMA6_XENTR Atf5 protein (Silurana tropicalis) 305 85.00% Cdc23 ARP43040_P050 Q8AVF0_XENLA Cdc23‐prov protein Xenopus laevis (African clawed frog) 522 100.00% Cdc23 ARP43040_P050 Q7T0N9_XENLA MGC69122 protein Xenopus laevis (African clawed frog) 580 100.00% Xenopus tropicalis (Western clawed frog) Cdc23 ARP43040_P050 Q28D09_XENTR CDC23 (Cell division cycle 23, yeast, homolog) (Silurana tropicalis) 581 100.00% ORF Names:AGAP006089OrganismAnophel LOC100127308 protein (Putative es gambiae (African malaria mosquito) ARP40341_P050 A9JS52_XENLA uncharacterized protein LOC100127308) Xenopus laevis (African clawed frog) 381 100.00%

ORF Names:AGAP006089OrganismAnophel es gambiae (African malaria mosquito) ARP40341_P050 RFOX2_XENLA Isoform 2 Xenopus laevis (African clawed frog) 443 100.00%

ORF RNA binding protein fox‐1 homolog 2 (Fox‐1 Names:AGAP006089OrganismAnophel homolog B) (RNA‐binding motif protein 9) Xenopus tropicalis (Western clawed frog) es gambiae (African malaria mosquito) ARP40341_P050 RFOX2_XENTR (RNA‐binding protein 9) (Silurana tropicalis) 380 100.00%

ORF RNA binding protein fox‐1 homolog 2 (Fox‐1 Names:AGAP006089OrganismAnophel homolog B) (RNA‐binding motif protein 9) es gambiae (African malaria mosquito) ARP40341_P050 RFOX2_XENLA (RNA‐binding protein 9) Xenopus laevis (African clawed frog) 411 100.00% LOC733328 ARP33755_P050 Q5XGK5_XENLA LOC495279 protein Xenopus laevis (African clawed frog) 1303 100.00% LOC733328 ARP33755_P050 Q4FZM0_XENLA LOC733328 protein (Fragment) Xenopus laevis (African clawed frog) 471 100.00% LOC733328 ARP33755_P050 A2VD55_XENLA LOC733328 protein (Fragment) Xenopus laevis (African clawed frog) 561 100.00% ARP38718_P050 Q9I8H0_XENLA Homeobox protein SIX1 Xenopus laevis (African clawed frog) 284 85.00% Xenopus tropicalis (Western clawed frog) ARP38718_P050 A4IHN6_XENTR Six1 protein (Silurana tropicalis) 284 78.00% LOC100037221 ARP50491_P050 A2VDC8_XENLA LOC100037221 protein (Fragment) Xenopus laevis (African clawed frog) 351 100.00% LOC733342 ARP46331_P050 Q52L11_XENLA LOC734150 protein (Fragment) Xenopus laevis (African clawed frog) 177 85.00% LOC733342 ARP46331_P050 Q3KQH0_XENLA LOC733342 protein (Fragment) Xenopus laevis (African clawed frog) 228 85.00% LOC733342 ARP46331_P050 Q0P3S0_XENLA LOC733342 protein (Fragment) Xenopus laevis (African clawed frog) 225 85.00% LOC733342 ARP46331_P050 A1A613_XENLA LOC733342 protein (Fragment) Xenopus laevis (African clawed frog) 225 85.00% Xenopus tropicalis (Western clawed frog) LOC733342 ARP46331_P050 A9JTN5_XENTR LOC100127804 protein (Silurana tropicalis) 304 84.00% Rasgrf1 ARP56516_P050 Q5XK82_XENLA LOC494866 protein (Fragment) Xenopus laevis (African clawed frog) 473 92.00% MEOX2 ARP32698_T100 Q7ZXL2_XENLA Meox2‐prov protein Xenopus laevis (African clawed frog) 298 85.00% Xenopus tropicalis (Western clawed frog) MEOX2 ARP32698_T100 B1H161_XENTR Meox2 protein (Silurana tropicalis) 300 85.00% MEOX2 ARP32698_T100 MEOX2_XENLA Homeobox protein MOX‐2 Xenopus laevis (African clawed frog) 298 85.00% CDH8 ARP46435_P050 CAD20_XENLA Cadherin‐20 (F‐cadherin) Xenopus laevis (African clawed frog) 790 92.00%

CDH8 ARP46435_P050 Q9DFS1_XENLA Cadherin 6, type 2, K‐cadherin (Cadherin‐6) Xenopus laevis (African clawed frog) 792 92.00% CDH8 ARP46435_P050 Q9DFS0_XENLA Cadherin‐6' Xenopus laevis (African clawed frog) 792 92.00% CDH8 ARP46435_P050 B7ZQK9_XENLA Cadherin 6, type 2, K‐cadherin Xenopus laevis (African clawed frog) 792 92.00% Xenopus tropicalis (Western clawed frog) CDH8 ARP46435_P050 Q5EAM2_XENTR Cadherin 11, type 2, OB‐cadherin (Osteoblast) (Silurana tropicalis) 794 92.00% CDH8 ARP46435_P050 O93264_XENLA Cadherin Xenopus laevis (African clawed frog) 794 92.00% Non‐structural maintenance of chromosomes element 1 homolog (Non‐SMC element 1 Xenopus tropicalis (Western clawed frog) ARP43407_T100 NSE1_XENTR homolog) (Silurana tropicalis) 270 78.00% Non‐structural maintenance of chromosomes element 1 homolog (Non‐SMC element 1 ARP43407_T100 NSE1_XENLA homolog) Xenopus laevis (African clawed frog) 270 78.00% Xenopus tropicalis (Western clawed frog) FKBP6 ARP43027_T100 Q6P889_XENTR FK506 binding protein 6 (Silurana tropicalis) 305 84.00% FKBP6 ARP43027_T100 Q6INU1_XENLA MGC80316 protein Xenopus laevis (African clawed frog) 304 84.00% TMED4 ARP41190_T100 Q7ZYH8_XENLA LOC398475 protein (Fragment) Xenopus laevis (African clawed frog) 241 100.00% TMED4 ARP41190_T100 Q6GLM7_XENLA MGC84702 protein Xenopus laevis (African clawed frog) 228 100.00% TMED4 ARP41190_T100 Q5PPT6_XENLA LOC398475 protein Xenopus laevis (African clawed frog) 214 100.00% Xenopus tropicalis (Western clawed frog) TMED4 ARP41190_T100 Q5FVX8_XENTR MGC108344 protein (Silurana tropicalis) 214 100.00% ORF Names:ACLA_057400 EMBL EAW15084.1OrganismAspergillus clavatus ARP48280_P050 Q6PA45_XENLA MGC68566 protein Xenopus laevis (African clawed frog) 289 92.00% Glucosamine‐6‐phosphate isomerase 2 (EC ORF Names:ACLA_057400 EMBL 3.5.99.6) (Glucosamine‐6‐phosphate EAW15084.1OrganismAspergillus deaminase 2) (GNPDA 2) (GlcN6P deaminase Xenopus tropicalis (Western clawed frog) clavatus ARP48280_P050 GNPI2_XENTR 2) (Silurana tropicalis) 275 92.00% Glucosamine‐6‐phosphate isomerase 2 (EC ORF Names:ACLA_057400 EMBL 3.5.99.6) (Glucosamine‐6‐phosphate EAW15084.1OrganismAspergillus deaminase 2) (GNPDA 2) (GlcN6P deaminase clavatus ARP48280_P050 GNPI2_XENLA 2) Xenopus laevis (African clawed frog) 275 92.00% Xenopus tropicalis (Western clawed frog) onecut1 ARP35750_T100 A4II00_XENTR Onecut1 protein (Silurana tropicalis) 493 91.00%

ORF Names:v1g98273OrganismNematostell a vectensis (Starlet sea anemone) ARP33161_T100 MYNN_XENLA Myoneurin Xenopus laevis (African clawed frog) 609 100.00% KRT13 ARP42031_T100 Q6DKC7_XENLA MGC84118 protein Xenopus laevis (African clawed frog) 458 83.00% KRT13 ARP42031_T100 Q5XGU0_XENLA LOC495266 protein Xenopus laevis (African clawed frog) 452 83.00%

ORF Names:GSTENG00021714001 EMBL CAG02567.1OrganismTetraodon nigroviridis (Green puffer) ARP39014_T100 Q6INU0_XENLA MGC80321 protein Xenopus laevis (African clawed frog) 257 100.00% Xenopus tropicalis (Western clawed frog) Toe1 ARP52410_P050 B0JZ51_XENTR LOC100145153 protein (Silurana tropicalis) 513 92.00% Rnf114 ARP33164_T100 Q6J2U7_XENLA Zfp313 protein (Fragment) Xenopus laevis (African clawed frog) 226 92.00% ORF Names:v1g242260OrganismNematostel la vectensis (Starlet sea anemone) ARP47419_P050 Q0Z849_XENLA Cdc4 Xenopus laevis (African clawed frog) 706 100.00% Rbbp9 ARP34703_P050 Q0P3R1_XENLA Putative uncharacterized protein Xenopus laevis (African clawed frog) 190 83.00% Xenopus tropicalis (Western clawed frog) ARP34684_T100 A0JPD2_XENTR Meis2 protein (Silurana tropicalis) 368 100.00% ARP34684_T100 B7ZRS8_XENLA Meis1 protein Xenopus laevis (African clawed frog) 465 92.00% ARP34684_T100 MEIS1_XENLA Isoform 2 (Isoform XMeis1‐2) (Isoform b) Xenopus laevis (African clawed frog) 465 92.00% ARP34684_T100 MEIS1_XENLA Homeobox protein Meis1 (XMeis1) Xenopus laevis (African clawed frog) 390 92.00% ARP34684_T100 MEI3A_XENLA Isoform 2 Xenopus laevis (African clawed frog) 385 75.00% Xenopus tropicalis (Western clawed frog) ARP34684_T100 MEIS3_XENTR Homeobox protein meis3 (Silurana tropicalis) 453 75.00% ARP34684_T100 MEI3B_XENLA Homeobox protein meis3‐B Xenopus laevis (African clawed frog) 451 75.00% ARP34684_T100 MEI3A_XENLA Homeobox protein meis3‐A (XMeis3) Xenopus laevis (African clawed frog) 453 75.00%

Ordered Locus Names:Bcen2424_0813OrganismBurkh olderia cenocepacia (strain HI2424) ARP43559_T100 Q6AZV2_XENLA Gcdh‐prov protein Xenopus laevis (African clawed frog) 440 92.00%

Ordered Locus Names:Bcen2424_0813OrganismBurkh Xenopus tropicalis (Western clawed frog) olderia cenocepacia (strain HI2424) ARP43559_T100 Q28CC9_XENTR Glutaryl‐Coenzyme A dehydrogenase (Silurana tropicalis) 440 92.00%

Ordered Locus Names:Bcen2424_0813OrganismBurkh Xenopus tropicalis (Western clawed frog) olderia cenocepacia (strain HI2424) ARP43559_T100 A4QND3_XENTR Glutaryl‐Coenzyme A dehydrogenase (Silurana tropicalis) 440 92.00% Ordered Locus Names:Shewana3_3539OrganismShew Xenopus tropicalis (Western clawed frog) anella sp. (strain ANA‐3) ARP41959_T100 Q5FVX4_XENTR Alpi.1 protein (Fragment) (Silurana tropicalis) 526 85.00% Ordered Locus Names:Shewana3_3539OrganismShew anella sp. (strain ANA‐3) ARP41959_T100 A1L2L6_XENLA LOC100036885 protein Xenopus laevis (African clawed frog) 530 85.00% Xenopus tropicalis (Western clawed frog) Acbd4 ARP49857_P050 Q0V9A4_XENTR Putative uncharacterized protein MGC147507 (Silurana tropicalis) 379 100.00% Xenopus tropicalis (Western clawed frog) Acbd4 ARP49857_P050 ACBD5_XENTR Acyl‐CoA‐binding domain‐containing protein 5 (Silurana tropicalis) 458 85.00%

Acbd4 ARP49857_P050 ACBD5_XENLA Acyl‐CoA‐binding domain‐containing protein 5 Xenopus laevis (African clawed frog) 467 85.00%

ORF Names:v1g167347OrganismNematostel la vectensis (Starlet sea anemone) ARP56466_P050 Q7T0M9_XENLA Psmb4 protein Xenopus laevis (African clawed frog) 248 78.00% Proteasome subunit beta type‐4 (Proteasome ORF beta chain) (EC 3.4.25.1) (Macropain beta Names:v1g167347OrganismNematostel chain) (Multicatalytic endopeptidase complex la vectensis (Starlet sea anemone) ARP56466_P050 PSB4_XENLA beta chain) (Proteasome chain 3) (Fragment) Xenopus laevis (African clawed frog) 242 78.00% ORF Names:SIAM614_10383 EMBL EAV46229.1OrganismLabrenzia Xenopus tropicalis (Western clawed frog) aggregata IAM 12614 ARP43568_P050 Q28CC9_XENTR Glutaryl‐Coenzyme A dehydrogenase (Silurana tropicalis) 440 92.00% ORF Names:SIAM614_10383 EMBL EAV46229.1OrganismLabrenzia Xenopus tropicalis (Western clawed frog) aggregata IAM 12614 ARP43568_P050 A4QND3_XENTR Glutaryl‐Coenzyme A dehydrogenase (Silurana tropicalis) 440 91.00% ORF Names:SIAM614_10383 EMBL EAV46229.1OrganismLabrenzia aggregata IAM 12614 ARP43568_P050 Q6AZV2_XENLA Gcdh‐prov protein Xenopus laevis (African clawed frog) 440 84.00% Xenopus tropicalis (Western clawed frog) mPRgamma‐1 ARP49900_P050 A9UMC5_XENTR LOC100135309 protein (Silurana tropicalis) 339 85.00% Progestin and adipoQ receptor family member Xenopus tropicalis (Western clawed frog) mPRgamma‐1 ARP49900_P050 Q08CW7_XENTR VI (Silurana tropicalis) 345 78.00% mPRgamma‐1 ARP49900_P050 Q52L08_XENLA MGC115032 protein Xenopus laevis (African clawed frog) 341 75.00% mPRgamma‐1 ARP49900_P050 Q6AX66_XENLA MGC84006 protein Xenopus laevis (African clawed frog) 341 75.00% Xenopus tropicalis (Western clawed frog) IL1RAPL1 ARP47297_P050 Q0IIY6_XENTR Interleukin 1 receptor accessory protein‐like 2 (Silurana tropicalis) 686 92.00% Xenopus tropicalis (Western clawed frog) IKZF3 ARP31470_P050 Q5FWQ9_XENTR IKAROS family zinc finger 1 (Ikaros) (Silurana tropicalis) 483 100.00% IKZF3 ARP31470_P050 O13100_9PIPI Ikaros homolog (Fragment) Xenopus laevis/gilli 138 100.00% IKZF3 ARP31470_P050 Q6GNC6_XENLA MGC82887 protein Xenopus laevis (African clawed frog) 513 91.00% Xenopus tropicalis (Western clawed frog) trim8 ARP39655_P050 Q4G0B7_XENTR Tripartite motif‐containing 8 (Silurana tropicalis) 551 92.00% trim8 ARP39655_P050 A8WH52_XENLA LOC100127258 protein Xenopus laevis (African clawed frog) 551 92.00% ORF Names:EAG_11411 EMBL EFN73251.1OrganismCamponotus floridanus ARP38502_P050 Q91835_XENLA POU domain protein (Fragment) Xenopus laevis (African clawed frog) 57 100.00% ORF Names:EAG_11411 EMBL EFN73251.1OrganismCamponotus floridanus ARP38502_P050 Q9DG50_XENLA Class IV POU‐homeodomain protein Xenopus laevis (African clawed frog) 343 92.00% ORF Names:EAG_11411 EMBL EFN73251.1OrganismCamponotus Class IV POU‐homeodomain protein floridanus ARP38502_P050 Q9DG32_XENLA (Fragment) Xenopus laevis (African clawed frog) 358 92.00% ORF Names:EAG_11411 EMBL EFN73251.1OrganismCamponotus Xenopus tropicalis (Western clawed frog) floridanus ARP38502_P050 A4IGJ4_XENTR Pou4f1.2 protein (Silurana tropicalis) 340 92.00% ccnd1 AVARP03037_P050 Q8AVQ4_XENLA Ccnd1‐prov protein Xenopus laevis (African clawed frog) 291 90.00% ccnd1 AVARP03037_P050 Q7ZYJ6_XENLA MGC52909 protein Xenopus laevis (African clawed frog) 291 90.00% Xenopus tropicalis (Western clawed frog) ccnd1 AVARP03037_P050 Q6GLD3_XENTR Cyclin D1 (Silurana tropicalis) 291 90.00% ccnd1 AVARP03037_P050 CCND1_XENLA G1/S‐specific cyclin‐D1 Xenopus laevis (African clawed frog) 291 90.00% Xenopus tropicalis (Western clawed frog) ccnd1 AVARP03037_P050 B2GU16_XENTR LOC100158484 protein (Silurana tropicalis) 291 81.00%

ORF Names:GSTENG00029762001 EMBL CAG08710.1OrganismTetraodon nigroviridis (Green puffer) ARP38977_P050 Q6GNC7_XENLA MGC82885 protein Xenopus laevis (African clawed frog) 513 100.00%

ORF Names:GSTENG00029762001 EMBL CAG08710.1OrganismTetraodon Xenopus tropicalis (Western clawed frog) nigroviridis (Green puffer) ARP38977_P050 Q642N2_XENTR HMG‐box transcription factor 1 (Silurana tropicalis) 531 100.00%

ORF Names:GSTENG00029762001 EMBL CAG08710.1OrganismTetraodon nigroviridis (Green puffer) ARP38977_P050 Q8JH80_XENLA HMG‐box‐containing protein HBP1 Xenopus laevis (African clawed frog) 515 100.00% Gm12355 ARP40438_P050 Q7ZWX7_XENLA Sfrs3‐prov protein Xenopus laevis (African clawed frog) 191 100.00% Splicing factor, arginine serine‐rich 3 (Splicing Xenopus tropicalis (Western clawed frog) Gm12355 ARP40438_P050 Q6DF01_XENTR factor, arginine/serine‐rich 3) (Silurana tropicalis) 164 100.00%

ORF Names:v1g236613OrganismNematostel ADP‐ribosylation factor‐like protein 8A (ADP‐ Xenopus tropicalis (Western clawed frog) la vectensis (Starlet sea anemone) ARP52641_P050 ARL8A_XENTR ribosylation factor‐like protein 10B) (Silurana tropicalis) 186 92.00%

ORF Names:v1g236613OrganismNematostel la vectensis (Starlet sea anemone) ARP52641_P050 Q6INP4_XENLA MGC81511 protein Xenopus laevis (African clawed frog) 166 85.00% Xenopus tropicalis (Western clawed frog) unc50 ARP46969_P050 B5DEV8_XENTR Putative uncharacterized protein (Silurana tropicalis) 259 100.00% unc50 ARP46969_P050 B3FTN0_XENLA UNC‐50‐like protein Xenopus laevis (African clawed frog) 259 92.00% unc50 ARP46969_P050 UN50A_XENLA Protein unc‐50 homolog A Xenopus laevis (African clawed frog) 259 92.00% unc50 ARP46969_P050 UN50B_XENLA Protein unc‐50 homolog B Xenopus laevis (African clawed frog) 259 92.00% EGL nine homolog 2 (C. elegans) (Egl nine Xenopus tropicalis (Western clawed frog) EGLN1 ARP34608_T100 Q28E59_XENTR homolog 1 (C. elegans)) (Silurana tropicalis) 394 92.00% EGLN1 ARP34608_T100 Q6DFD1_XENLA Egln2‐prov protein Xenopus laevis (African clawed frog) 408 84.00% ARP52402_P050 D0VPT3_XENLA EGL nine homolog 2 Xenopus laevis (African clawed frog) 454 76.00% ARP52402_P050 B0JZW2_XENLA LOC100158265 protein (Fragment) Xenopus laevis (African clawed frog) 263 76.00% ARP45627_P050 O42178_XENLA ErbA‐related protein 2 (Fragment) Xenopus laevis (African clawed frog) 63 78.00% ARP45627_P050 Q7T0T7_XENLA Nr2f6 protein Xenopus laevis (African clawed frog) 389 78.00% Nuclear receptor subfamily 2, group F, Xenopus tropicalis (Western clawed frog) ARP45627_P050 Q6GL59_XENTR member 6 (Silurana tropicalis) 389 78.00% Xenopus tropicalis (Western clawed frog) KCNC1 ARP46558_T100 B0BM00_XENTR LOC100144936 protein (Fragment) (Silurana tropicalis) 458 92.00% ORF Names:GSPATT00028634001 EMBL CAK57599.1OrganismParamecium tetraurelia ARP53587_P050 Q6GN87_XENLA MGC82953 protein Xenopus laevis (African clawed frog) 445 78.00% Xenopus tropicalis (Western clawed frog) Dnajc5 ARP52499_P050 DNJB6_XENTR DnaJ homolog subfamily B member 6 (Silurana tropicalis) 242 92.00% Dnajc5 ARP52499_P050 DNJ6B_XENLA DnaJ homolog subfamily B member 6‐B Xenopus laevis (African clawed frog) 245 92.00% Dnajc5 ARP52499_P050 DNJ6A_XENLA DnaJ homolog subfamily B member 6‐A Xenopus laevis (African clawed frog) 250 92.00% Dnajc5 ARP52499_P050 CSP_XENLA Cysteine string protein (CSP) (Xcsp) Xenopus laevis (African clawed frog) 197 75.00% DnaJ (Hsp40) homolog, subfamily C, member Xenopus tropicalis (Western clawed frog) Dnajc5 ARP52499_P050 Q28EC4_XENTR 5 (Silurana tropicalis) 199 75.00% Xenopus tropicalis (Western clawed frog) Dnajc5 ARP52499_P050 Q05AT3_XENTR LOC548742 protein (Silurana tropicalis) 197 75.00%

ORF Names:BRAFLDRAFT_128129 EMBL EEN65067.1OrganismBranchiostoma Xenopus tropicalis (Western clawed frog) floridae (Florida lancelet) (Amphioxus) ARP41052_T100 B2GU14_XENTR LOC100158482 protein (Silurana tropicalis) 322 85.00% ORF Names:ACLA_070390 EMBL EAW14007.1OrganismAspergillus clavatus ARP56456_P050 Q6GP03_XENLA MGC80760 protein Xenopus laevis (African clawed frog) 247 100.00% ORF Names:ACLA_070390 EMBL EAW14007.1OrganismAspergillus clavatus ARP56456_P050 Q68A89_XENLA 20S proteasome alpha5 subunit (Fragment) Xenopus laevis (African clawed frog) 241 100.00% ORF Names:ACLA_070390 EMBL EAW14007.1OrganismAspergillus Xenopus tropicalis (Western clawed frog) clavatus ARP56456_P050 A4IHI3_XENTR LOC100124849 protein (Silurana tropicalis) 241 100.00%

ORF Names:v1g130381OrganismNematostel la vectensis (Starlet sea anemone) ARP40735_T100 Q6AXA7_XENLA MGC80263 protein Xenopus laevis (African clawed frog) 948 100.00%

ORF Names:v1g130381OrganismNematostel Xenopus tropicalis (Western clawed frog) la vectensis (Starlet sea anemone) ARP40735_T100 Q5BJ59_XENTR MGC97740 protein (Silurana tropicalis) 972 100.00% RNF6 ARP43065_P050 Q7T036_XENLA XRnf12C Xenopus laevis (African clawed frog) 825 85.00% Xenopus tropicalis (Western clawed frog) RNF6 ARP43065_P050 B7ZUL1_XENTR Ring finger protein, LIM domain interacting (Silurana tropicalis) 639 85.00% RNF6 ARP43065_P050 B7ZR09_XENLA XRnf12C protein Xenopus laevis (African clawed frog) 751 85.00% RNF6 ARP43065_P050 RF12A_XENLA Isoform 2 Xenopus laevis (African clawed frog) 616 85.00% E3 ubiquitin‐protein ligase RNF12 (EC 6.3.2.‐) Xenopus tropicalis (Western clawed frog) RNF6 ARP43065_P050 RNF12_XENTR (RING finger protein 12) (Silurana tropicalis) 639 85.00%

E3 ubiquitin‐protein ligase RNF12‐B (EC 6.3.2.‐ RNF6 ARP43065_P050 RF12B_XENLA ) (RING finger protein 12‐B) (XRnf12B) Xenopus laevis (African clawed frog) 757 85.00%

E3 ubiquitin‐protein ligase RNF12‐A (EC 6.3.2.‐ RNF6 ARP43065_P050 RF12A_XENLA ) (RING finger protein 12‐A) (XRnf12) Xenopus laevis (African clawed frog) 622 85.00% has1 ARP45426_P050 Q7ZYA9_XENLA Ssr1 protein (Fragment) Xenopus laevis (African clawed frog) 293 85.00% has1 ARP45426_P050 Q6PGS0_XENLA MGC64448 protein Xenopus laevis (African clawed frog) 286 85.00% Xenopus tropicalis (Western clawed frog) has1 ARP45426_P050 Q6NVB4_XENTR Ssr1 protein (Ssr1‐prov protein) (Silurana tropicalis) 291 85.00% has1 ARP45426_P050 Q6DCM6_XENLA Ssr1 protein Xenopus laevis (African clawed frog) 291 85.00% Signal sequence receptor, alpha (Translocon‐ Xenopus tropicalis (Western clawed frog) has1 ARP45426_P050 Q28EA7_XENTR associated protein alpha) (Silurana tropicalis) 286 85.00% Xenopus tropicalis (Western clawed frog) Cops2 ARP34188_P050 Q5EB36_XENTR MGC97656 protein (Silurana tropicalis) 443 100.00% Cops2 ARP34188_P050 Q2VPH6_XENLA LOC432342 protein Xenopus laevis (African clawed frog) 443 100.00% COP9 signalosome complex subunit 2 Cops2 ARP34188_P050 CSN2_XENLA (Signalosome subunit 2) (Fragment) Xenopus laevis (African clawed frog) 441 100.00%

ORF Names:GSTENG00020701001 EMBL CAG01813.1OrganismTetraodon nigroviridis (Green puffer) ARP50843_P050 Q6GLQ0_XENLA MGC84406 protein Xenopus laevis (African clawed frog) 783 92.00% nkx6.2 ARP39907_P050 Q0IHB4_XENLA Nkx6‐2 protein Xenopus laevis (African clawed frog) 281 92.00% nkx6.2 ARP39907_P050 NKX63_XENLA Homeobox protein Nkx‐6.3 Xenopus laevis (African clawed frog) 254 92.00% Xenopus tropicalis (Western clawed frog) nkx6.2 ARP39907_P050 Q0P4K6_XENTR Nkx6‐1 protein (Silurana tropicalis) 89 85.00% Xenopus tropicalis (Western clawed frog) nkx6.2 ARP39907_P050 A5YC50_XENTR NK6 transcription factor related locus 1 (Silurana tropicalis) 342 85.00% nkx6.2 ARP39907_P050 A5YC48_XENLA NK6 transcription factor related locus 1 Xenopus laevis (African clawed frog) 351 85.00% ARP39356_P050 Q6GN57_XENLA LOC443681 protein (Fragment) Xenopus laevis (African clawed frog) 636 83.00% ARP39356_P050 Q2T9I7_XENLA LOC443681 protein Xenopus laevis (African clawed frog) 612 83.00% POLR2H ARP48697_T100 Q6GQD4_XENLA MGC80152 protein Xenopus laevis (African clawed frog) 150 100.00% Txn2 ARP54909_P050 Q7ZYG6_XENLA Txn2‐prov protein Xenopus laevis (African clawed frog) 170 85.00% Xenopus tropicalis (Western clawed frog) Txn2 ARP54909_P050 Q641J6_XENTR Thioredoxin 2 (Txn2 protein) (Silurana tropicalis) 170 85.00% Xenopus tropicalis (Western clawed frog) Txn2 ARP54909_P050 Q28F90_XENTR Thioredoxin 2 (Fragment) (Silurana tropicalis) 119 85.00% Xenopus tropicalis (Western clawed frog) thoc3 ARP41051_P050 B2GU14_XENTR LOC100158482 protein (Silurana tropicalis) 322 84.00% ARP33730_P050 Q9I9Q6_XENLA Clock Xenopus laevis (African clawed frog) 825 100.00% Xenopus tropicalis (Western clawed frog) CLOCK ARP33730_P050 B3DM05_XENTR Clock protein (Silurana tropicalis) 829 100.00% CLOCK ARP33730_P050 Q9PUA3_XENLA Circadian rhythmicity protein CLOCK Xenopus laevis (African clawed frog) 778 92.00%

ORF Names:v1g189255OrganismNematostel la vectensis (Starlet sea anemone) ARP38189_T100 Q7ZTR7_XENLA Psmc2 protein (Fragment) Xenopus laevis (African clawed frog) 444 85.00%

ORF 26S protease regulatory subunit 7 Names:v1g189255OrganismNematostel (Proteasome (Prosome, macropain) 26S Xenopus tropicalis (Western clawed frog) la vectensis (Starlet sea anemone) ARP38189_T100 Q6P7K3_XENTR subunit, ATPase 2) (Silurana tropicalis) 433 85.00%

ORF Names:v1g189255OrganismNematostel Xenopus tropicalis (Western clawed frog) la vectensis (Starlet sea anemone) ARP38189_T100 Q68ER4_XENTR 26S protease regulatory subunit 7 (Silurana tropicalis) 433 85.00%

ORF Names:v1g189255OrganismNematostel la vectensis (Starlet sea anemone) ARP38189_T100 A9ULV8_XENLA XMSS1 protein Xenopus laevis (African clawed frog) 433 85.00% 26S protease regulatory subunit 7 (26S ORF proteasome AAA‐ATPase subunit RPT1) Names:v1g189255OrganismNematostel (Proteasome 26S subunit ATPase 2) (Protein la vectensis (Starlet sea anemone) ARP38189_T100 PRS7_XENLA MSS1) (xMSS1) Xenopus laevis (African clawed frog) 433 85.00% ORF Names:Esi_0152_0023 EMBL CBN78858.1OrganismEctocarpus siliculosus (Brown alga) ARP40643_P050 Q68F05_XENLA MGC83231 protein Xenopus laevis (African clawed frog) 933 100.00% ORF Names:Esi_0152_0023 EMBL CBN78858.1OrganismEctocarpus Calcium homeostasis endoplasmic reticulum Xenopus tropicalis (Western clawed frog) siliculosus (Brown alga) ARP40643_P050 Q5XGE8_XENTR protein (Silurana tropicalis) 944 100.00% ORF Names:Esi_0152_0023 EMBL CBN78858.1OrganismEctocarpus siliculosus (Brown alga) ARP40643_P050 Q7ZWT5_XENLA Cherp‐prov protein Xenopus laevis (African clawed frog) 924 100.00% trim24 ARP38391_P050 B7ZRX2_XENLA Ectodermin Xenopus laevis (African clawed frog) 1091 86.00% trim24 ARP38391_P050 B7ZRU5_XENLA Ectodermin Xenopus laevis (African clawed frog) 1091 86.00%

E3 ubiquitin‐protein ligase TRIM33 (EC 6.3.2.‐) (Ectodermin) (Transcription intermediary factor 1‐gamma) (TIF1‐gamma) (Tripartite trim24 ARP38391_P050 TRI33_XENLA motif‐containing protein 33) Xenopus laevis (African clawed frog) 1091 86.00% Xenopus tropicalis (Western clawed frog) trim24 ARP38391_P050 B2GUB1_XENTR LOC100158542 protein (Silurana tropicalis) 1040 84.00% ARP54879_P050 Q70PC5_XENLA Importin alpha 5.1 protein Xenopus laevis (African clawed frog) 537 92.00% ARP54879_P050 Q70PC4_XENLA Importin alpha 5.2 protein Xenopus laevis (African clawed frog) 537 92.00% ARP54879_P050 Q6IP69_XENLA Putative uncharacterized protein Xenopus laevis (African clawed frog) 537 92.00% Xenopus tropicalis (Western clawed frog) ARP54879_P050 Q642T8_XENTR Kpna6 protein (Silurana tropicalis) 534 92.00% PAXIP1 ARP51642_P050 Q6DDH5_XENLA K14 protein Xenopus laevis (African clawed frog) 1320 100.00%

PAX‐interacting protein 1 (PAX transactivation activation domain‐interacting protein) (SMAD wing for transcriptional activation) (Protein PAXIP1 ARP51642_P050 PAXI1_XENLA Swift) Xenopus laevis (African clawed frog) 1256 100.00% ORF Names:Bm1_41005 EMBL EDP31384.1OrganismBrugia malayi (Filarial nematode worm) ARP48212_T100 Q6IRM0_XENLA MGC84633 protein Xenopus laevis (African clawed frog) 186 100.00% ORF Names:Bm1_41005 EMBL EDP31384.1OrganismBrugia malayi (Filarial nematode worm) ARP48212_T100 Q6GPR7_XENLA MGC82659 protein Xenopus laevis (African clawed frog) 186 100.00% ORF Names:Bm1_41005 EMBL EDP31384.1OrganismBrugia malayi (Filarial nematode worm) ARP48212_T100 Q3B8K8_XENLA MGC82659 protein Xenopus laevis (African clawed frog) 186 100.00% ORF Names:Bm1_41005 EMBL EDP31384.1OrganismBrugia malayi Xenopus tropicalis (Western clawed frog) (Filarial nematode worm) ARP48212_T100 Q28DG3_XENTR Phosphatidylethanolamine‐binding protein (Silurana tropicalis) 186 100.00% atic ARP46095_T100 Q6ING0_XENLA LOC443576 protein (Fragment) Xenopus laevis (African clawed frog) 593 92.00% 5‐aminoimidazole‐4‐carboxamide ribonucleotide formyltransferase/IMP Xenopus tropicalis (Western clawed frog) atic ARP46095_T100 Q6GLB6_XENTR cyclohydrolase (Silurana tropicalis) 589 92.00% atic ARP46095_T100 Q3KQ54_XENLA MGC130953 protein Xenopus laevis (African clawed frog) 589 92.00% ORF Names:M23134_05333 EMBL Transcription factor E2‐alpha (Transcription EAY30000.1OrganismMicroscilla marina factor 3) (TCF‐3) (Transcription factor ATCC 23134 P100871_T100 TFE2_XENLA XE12/XE47) Xenopus laevis (African clawed frog) 658 86.00% ORF Names:M23134_05333 EMBL EAY30000.1OrganismMicroscilla marina ATCC 23134 P100871_T100 Q91608_XENLA XE3 (Fragment) Xenopus laevis (African clawed frog) 130 78.00% ORF Names:M23134_05333 EMBL EAY30000.1OrganismMicroscilla marina ATCC 23134 P100871_T100 Q7ZXY5_XENLA Tcfe2a‐prov protein Xenopus laevis (African clawed frog) 657 78.00% ORF Names:OsI_02309 EMBL EAY74420.1OrganismOryza sativa subsp. indica (Rice) ARP38170_P050 Q9PUA3_XENLA Circadian rhythmicity protein CLOCK Xenopus laevis (African clawed frog) 778 85.00%

RNA‐binding protein 8A (RNA‐binding motif Xenopus tropicalis (Western clawed frog) GL17620 ARP40576_T100 RBM8A_XENTR protein 8A) (Ribonucleoprotein RBM8A) (Silurana tropicalis) 174 100.00% RNA‐binding protein 8A‐B (RNA‐binding motif GL17620 ARP40576_T100 RB8AB_XENLA protein 8A‐B) (Ribonucleoprotein RBM8A‐B) Xenopus laevis (African clawed frog) 174 100.00%

RNA‐binding protein 8A‐A (RNA‐binding motif GL17620 ARP40576_T100 RB8AA_XENLA protein 8A‐A) (Ribonucleoprotein RBM8A‐A) Xenopus laevis (African clawed frog) 174 92.00% znf207b ARP33552_P050 Q7ZXV8_XENLA 4m77‐prov protein Xenopus laevis (African clawed frog) 452 92.00% Xenopus tropicalis (Western clawed frog) znf207b ARP33552_P050 Q6P368_XENTR Zinc finger protein 207 (Silurana tropicalis) 453 92.00% Xenopus tropicalis (Western clawed frog) znf207b ARP33552_P050 Q28FC3_XENTR Zinc finger protein 207 (Silurana tropicalis) 453 92.00% ARP56350_P050 Q10833_XENLA Collagenase‐3 Xenopus laevis (African clawed frog) 472 83.00%

Collagenase 3 (EC 3.4.24.‐) (Matrix ARP56350_P050 MMP13_XENLA metalloproteinase‐13) (MMP‐13) (Fragment) Xenopus laevis (African clawed frog) 469 83.00%

ORF Names:DKEY‐200H23.6‐001 EMBL CAP09537.1OrganismDanio rerio (Zebrafish) (Brachydanio rerio) ARP56465_P050 Q7T0M9_XENLA Psmb4 protein Xenopus laevis (African clawed frog) 248 84.00%

ORF Names:DKEY‐200H23.6‐001 EMBL CAP09537.1OrganismDanio rerio Proteasome (Prosome macropain) subunit Xenopus tropicalis (Western clawed frog) (Zebrafish) (Brachydanio rerio) ARP56465_P050 Q5RJU8_XENTR beta type 4 (Silurana tropicalis) 248 84.00%

ORF Names:DKEY‐200H23.6‐001 EMBL CAP09537.1OrganismDanio rerio Proteasome (Prosome macropain) subunit Xenopus tropicalis (Western clawed frog) (Zebrafish) (Brachydanio rerio) ARP56465_P050 Q28BW4_XENTR beta type 4 (Silurana tropicalis) 243 84.00%

Proteasome subunit beta type‐4 (Proteasome ORF Names:DKEY‐200H23.6‐001 EMBL beta chain) (EC 3.4.25.1) (Macropain beta CAP09537.1OrganismDanio rerio chain) (Multicatalytic endopeptidase complex (Zebrafish) (Brachydanio rerio) ARP56465_P050 PSB4_XENLA beta chain) (Proteasome chain 3) (Fragment) Xenopus laevis (African clawed frog) 242 84.00% ATP‐dependent RNA helicase DDX1 (EC Xenopus tropicalis (Western clawed frog) ARP37712_T100 DDX1_XENTR 3.6.4.13) (DEAD box protein 1) (Silurana tropicalis) 740 85.00% ATP‐dependent RNA helicase DDX1 (EC ARP37712_T100 DDX1_XENLA 3.6.4.13) (DEAD box protein 1) Xenopus laevis (African clawed frog) 740 78.00% RFC2 protein (Replication factor C p37 Rfc4 ARP46087_P050 Q76LD2_XENLA subunit) Xenopus laevis (African clawed frog) 363 100.00% Xenopus tropicalis (Western clawed frog) Rfc4 ARP46087_P050 Q28GP1_XENTR Replication factor C (Activator 1) 4, 37kDa (Silurana tropicalis) 360 100.00% ORF Names:ACLA_036820 EMBL EAW09477.1OrganismAspergillus clavatus ARP51893_P050 Q6DJD1_XENLA Copa‐prov protein Xenopus laevis (African clawed frog) 1224 100.00% ORF Names:ACLA_036820 EMBL EAW09477.1OrganismAspergillus Xenopus tropicalis (Western clawed frog) clavatus ARP51893_P050 B2GUD5_XENTR LOC100158562 protein (Silurana tropicalis) 1224 100.00% VGLL2 ARP50815_P050 Q7T0X1_XENLA Vgll2‐prov protein Xenopus laevis (African clawed frog) 317 100.00% Xenopus tropicalis (Western clawed frog) VGLL2 ARP50815_P050 Q6P4L0_XENTR Vestigial like 2 (Drosophila) (Silurana tropicalis) 317 100.00% Xenopus tropicalis (Western clawed frog) VGLL2 ARP50815_P050 Q0VFB1_XENTR Vestigial like 3 (Silurana tropicalis) 244 100.00% ALG11 ARP44462_P050 ALG11_XENLA Isoform 2 Xenopus laevis (African clawed frog) 419 78.00% Asparagine‐linked glycosylation protein 11 ALG11 ARP44462_P050 ALG11_XENLA homolog (EC 2.4.‐.‐) Xenopus laevis (African clawed frog) 486 78.00% Asparagine‐linked glycosylation protein 11 Xenopus tropicalis (Western clawed frog) ALG11 ARP44462_P050 ALG11_XENTR homolog (EC 2.4.‐.‐) (Silurana tropicalis) 487 84.00% TaSK5 ARP54644_P050 Q91757_XENLA Intracellular kinase (Xgsk‐3 protein) Xenopus laevis (African clawed frog) 420 92.00% TaSK5 ARP54644_P050 Q91627_XENLA Glycogen synthase kinase 3 beta Xenopus laevis (African clawed frog) 420 92.00% Xenopus tropicalis (Western clawed frog) TaSK5 ARP54644_P050 B1H3G0_XENTR Gsk3a protein (Fragment) (Silurana tropicalis) 434 78.00%

TaSK5 ARP54644_P050 B1H1U4_XENLA Putative uncharacterized protein (Fragment) Xenopus laevis (African clawed frog) 389 78.00% Xenopus tropicalis (Western clawed frog) Snap23 ARP48615_P050 A9UL74_XENTR LOC100135161 protein (Silurana tropicalis) 205 85.00% SNAP‐23 (Synaptosomal‐associated protein, Snap23 ARP48615_P050 Q8JIS7_XENLA 23kDa) Xenopus laevis (African clawed frog) 204 78.00% Snap23 ARP48615_P050 Q8AXM1_XENLA SNAP25b (Snap25‐prov protein) Xenopus laevis (African clawed frog) 206 78.00% Snap23 ARP48615_P050 Q640W4_XENLA Snap25 protein Xenopus laevis (African clawed frog) 206 78.00%

Synaptosomal‐associated protein 25 Xenopus tropicalis (Western clawed frog) Snap23 ARP48615_P050 Q28HP6_XENTR (Synaptosomal‐associated protein, 25kDa) (Silurana tropicalis) 206 78.00% ALDH3A1 ARP44274_P050 Q6GR28_XENLA Aldehyde dehydrogenase Xenopus laevis (African clawed frog) 506 92.00% ALDH3A1 ARP44274_P050 Q5HZS5_XENLA Aldehyde dehydrogenase Xenopus laevis (African clawed frog) 483 92.00% Xenopus tropicalis (Western clawed frog) ALDH3A1 ARP44274_P050 Q5BKL3_XENTR Aldehyde dehydrogenase (Silurana tropicalis) 486 92.00%

Metal transporter CNNM4 (Ancient conserved Xenopus tropicalis (Western clawed frog) cnnm4 ARP49481_P050 CNNM4_XENTR domain‐containing protein 4) (Cyclin‐M4) (Silurana tropicalis) 769 83.00% MGC152360 ARP40437_P050 Q7ZXV2_XENLA MGC52808 protein Xenopus laevis (African clawed frog) 595 78.00% MGC152360 ARP40437_P050 Q7ZX69_XENLA MGC52894 protein Xenopus laevis (African clawed frog) 595 78.00% Xenopus tropicalis (Western clawed frog) MGC152360 ARP40437_P050 Q6P1S9_XENTR Ribophorin I (Silurana tropicalis) 595 76.00% GH12526 ARP33075_P050 Q98SG0_XENLA Beta‐amyloid protein A Xenopus laevis (African clawed frog) 693 92.00% GH12526 ARP33075_P050 Q98SF9_XENLA Beta‐amyloid protein B Xenopus laevis (African clawed frog) 695 92.00% GH12526 ARP33075_P050 Q91963_9PIPI APP747 Xenopus 747 92.00% GH12526 ARP33075_P050 Q7ZXQ0_XENLA MGC52816 protein Xenopus laevis (African clawed frog) 695 92.00% GH12526 ARP33075_P050 Q6NRR1_XENLA App protein Xenopus laevis (African clawed frog) 749 92.00% Xenopus tropicalis (Western clawed frog) GH12526 ARP33075_P050 Q6DJB6_XENTR Amyloid beta (A4) protein (Silurana tropicalis) 750 85.00%

Cyclin‐dependent kinase 9 (EC 2.7.11.22) (EC Xenopus tropicalis (Western clawed frog) Cdk9 AVARP03004_T100 CDK9_XENTR 2.7.11.23) (Cell division protein kinase 9) (Silurana tropicalis) 376 91.00% Cyclin‐dependent kinase 9‐B (EC 2.7.11.22) (EC 2.7.11.23) (Cell division protein kinase 9‐ Cdk9 AVARP03004_T100 CDK9B_XENLA B) Xenopus laevis (African clawed frog) 376 91.00% Cyclin‐dependent kinase 9‐A (EC 2.7.11.22) (EC 2.7.11.23) (Cell division protein kinase 9‐ Cdk9 AVARP03004_T100 CDK9A_XENLA A) Xenopus laevis (African clawed frog) 376 91.00% Xenopus tropicalis (Western clawed frog) insm1 ARP30029_P050 Q0VA44_XENTR Insm1 protein (Fragment) (Silurana tropicalis) 303 100.00% insm1 ARP30029_P050 A7UKY7_XENLA Insuloma‐associated 1 Xenopus laevis (African clawed frog) 433 100.00% Xenopus tropicalis (Western clawed frog) insm1 ARP30029_P050 A4IHR5_XENTR Insm1 protein (Silurana tropicalis) 441 100.00%

ORF Names:CH211‐15E22.3‐001 EMBL CAX13902.1OrganismDanio rerio Xenopus tropicalis (Western clawed frog) (Zebrafish) (Brachydanio rerio) ARP48800_P050 Q0IIR5_XENTR GalNAc 10 (Silurana tropicalis) 603 92.00% Lipoyl synthase, mitochondrial (EC 2.8.1.8) (Lipoate synthase) (LS) (Lip‐syn) (Lipoic acid ARP48716_P050 LIAS_XENLA synthase) Xenopus laevis (African clawed frog) 372 91.00% Xenopus tropicalis (Western clawed frog) ARP48716_P050 Q5M8W4_XENTR Lipoic acid synthetase (Silurana tropicalis) 327 91.00% 45 kDa calcium‐binding protein (Cab45) Xenopus tropicalis (Western clawed frog) ARP47223_P050 CAB45_XENTR (Stromal cell‐derived factor 4) (SDF‐4) (Silurana tropicalis) 360 91.00% 45 kDa calcium‐binding protein (Cab45) ARP47223_P050 CAB45_XENLA (Stromal cell‐derived factor 4) (SDF‐4) Xenopus laevis (African clawed frog) 360 91.00% dcun1d4 ARP54513_P050 Q66J06_XENLA MGC83600 protein Xenopus laevis (African clawed frog) 232 85.00% Xenopus tropicalis (Western clawed frog) dcun1d4 ARP54513_P050 Q28G81_XENTR Conserved protein MGC2714 (Silurana tropicalis) 232 85.00% Xenopus tropicalis (Western clawed frog) dcun1d4 ARP54513_P050 B3DL42_XENTR Putative uncharacterized protein LOC549057 (Silurana tropicalis) 232 85.00% MGC85513 protein (P24 delta1 putative cargo bai ARP58728_P050 Q9PT59_XENLA receptor) Xenopus laevis (African clawed frog) 207 100.00% bai ARP58728_P050 Q7ZYB5_XENLA LOC779015 protein (Fragment) Xenopus laevis (African clawed frog) 199 100.00% bai ARP58728_P050 Q7SZ16_XENLA MGC64308 protein Xenopus laevis (African clawed frog) 207 100.00%

Putative uncharacterized protein LOC549012 Xenopus tropicalis (Western clawed frog) bai ARP58728_P050 Q28FV9_XENTR (Transmembrane trafficking protein (TMP21)) (Silurana tropicalis) 207 100.00% bai ARP58728_P050 Q91841_XENLA Translocon‐associated protein Xenopus laevis (African clawed frog) 205 92.00% bai ARP58728_P050 Q7SZ37_XENLA Tmp21 protein Xenopus laevis (African clawed frog) 205 92.00% Transmembrane emp24‐like trafficking Xenopus tropicalis (Western clawed frog) bai ARP58728_P050 Q66KJ4_XENTR protein 10 (Silurana tropicalis) 206 92.00% Tnnt3 ARP51287_T100 Q7ZXG9_XENLA Tnnt3a protein Xenopus laevis (African clawed frog) 276 100.00% Tnnt3 ARP51287_T100 Q7T2Z8_XENLA Fast troponin T Xenopus laevis (African clawed frog) 276 100.00% Tnnt3 ARP51287_T100 Q71N35_XENLA Troponin T3 Xenopus laevis (African clawed frog) 273 100.00% Xenopus tropicalis (Western clawed frog) Tnnt3 ARP51287_T100 Q6P8D4_XENTR Troponin T type 3 (Skeletal, fast) (Silurana tropicalis) 244 100.00% Tnnt3 ARP51287_T100 Q66L12_XENLA LOC446917 protein (Fragment) Xenopus laevis (African clawed frog) 79 100.00% Tnnt3 ARP51287_T100 Q32N26_XENLA Tnnt3a protein Xenopus laevis (African clawed frog) 273 100.00% Xenopus tropicalis (Western clawed frog) Tnnt3 ARP51287_T100 Q28IC4_XENTR Troponin T3, skeletal, fast (Silurana tropicalis) 270 100.00% Tnnt3 ARP51287_T100 Q08B15_XENLA LOC100158366 protein Xenopus laevis (African clawed frog) 317 100.00% Tnnt3 ARP51287_T100 A8E5Y2_XENLA Putative uncharacterized protein Xenopus laevis (African clawed frog) 244 100.00% Xenopus tropicalis (Western clawed frog) ARP39920_P050 Q66JB5_XENTR MGC79816 protein (Silurana tropicalis) 518 100.00% ORF Names:Bm1_41830 EMBL EDP31341.1OrganismBrugia malayi (Filarial nematode worm) ARP40370_P050 B1WBD3_XENLA LOC100158432 protein Xenopus laevis (African clawed frog) 968 85.00% Xenopus tropicalis (Western clawed frog) SBD1 ARP48234_P050 Q28CY4_XENTR Selenium binding protein 1 (Silurana tropicalis) 409 85.00% Xenopus tropicalis (Western clawed frog) SBD1 ARP48234_P050 SBP1_XENTR Selenium‐binding protein 1 (Silurana tropicalis) 472 85.00% SBD1 ARP48234_P050 SBP1B_XENLA Selenium‐binding protein 1‐B Xenopus laevis (African clawed frog) 472 85.00% SBD1 ARP48234_P050 SBP1A_XENLA Selenium‐binding protein 1‐A Xenopus laevis (African clawed frog) 472 85.00% Regulators of G protein signaling XRGSVI Rgs2 ARP42827_T100 Q9IB54_XENLA (Fragment) Xenopus laevis (African clawed frog) 67 78.00% Rgs2 ARP42827_T100 Q5U532_XENLA LOC495384 protein Xenopus laevis (African clawed frog) 215 78.00% Xenopus tropicalis (Western clawed frog) Rgs2 ARP42827_T100 Q5BKF9_XENTR Rgs2 protein (Silurana tropicalis) 217 78.00% Rgs2 ARP42827_T100 Q32N12_XENLA Putative uncharacterized protein Xenopus laevis (African clawed frog) 216 78.00% Xenopus tropicalis (Western clawed frog) Kctd6 ARP35425_T100 B4F752_XENTR Putative uncharacterized protein (Silurana tropicalis) 237 85.00% phf12 ARP50416_P050 Q7ZYH3_XENLA Phf12‐prov protein Xenopus laevis (African clawed frog) 978 84.00% Xenopus tropicalis (Western clawed frog) phf12 ARP50416_P050 A1L0Y8_XENTR LOC100036708 protein (Silurana tropicalis) 985 84.00% ARP37502_T100 B7ZRR5_XENLA Xebf‐3 protein Xenopus laevis (African clawed frog) 597 78.00% Xenopus tropicalis (Western clawed frog) ARP37502_T100 A9ULR8_XENTR LOC100135240 protein (Fragment) (Silurana tropicalis) 496 78.00% Transcription factor COE3 (xCOE3) (Olf‐1/EBF‐ ARP37502_T100 COE3_XENLA like 2) (OE‐2) (xEBF‐3) (xOE‐2) Xenopus laevis (African clawed frog) 598 78.00% Xenopus tropicalis (Western clawed frog) ARP40500_P050 B4F6L9_XENTR Putative uncharacterized protein (Silurana tropicalis) 1553 85.00% ORF Names:v1g189228OrganismNematostel la vectensis (Starlet sea anemone) AVARP03049_T100 Q566I2_XENLA MGC115014 protein Xenopus laevis (African clawed frog) 776 100.00%

ORF Names:v1g189228OrganismNematostel la vectensis (Starlet sea anemone) AVARP03049_T100 Q4V7X4_XENLA MGC114992 protein Xenopus laevis (African clawed frog) 776 100.00%

ORF Names:v1g189228OrganismNematostel Xenopus tropicalis (Western clawed frog) la vectensis (Starlet sea anemone) AVARP03049_T100 Q1KMU1_XENTR Cullin‐1 (Silurana tropicalis) 776 100.00% Xenopus tropicalis (Western clawed frog) GG19255 ARP46018_P050 Q6GLA6_XENTR Parvin, beta (Silurana tropicalis) 365 92.00% GG19255 ARP46018_P050 Q4QQZ5_XENLA MGC115486 protein Xenopus laevis (African clawed frog) 365 92.00% ORF Names:ACLA_002890 EMBL EAW14878.1OrganismAspergillus ATPase, H+ transporting, lysosomal 70kDa, V1 Xenopus tropicalis (Western clawed frog) clavatus ARP56324_P050 Q68F94_XENTR subunit A (Silurana tropicalis) 617 90.00% ORF Names:ACLA_002890 EMBL EAW14878.1OrganismAspergillus clavatus ARP56324_P050 Q4KLX0_XENLA MGC114675 protein Xenopus laevis (African clawed frog) 617 90.00% Novel protein similar to srp14 (Signal recognition particle 14kDa (Homologous Alu Xenopus tropicalis (Western clawed frog) Srp14 ARP40454_T100 Q6AZK8_XENTR RNA binding protein)) (Silurana tropicalis) 110 100.00% Srp14 ARP40454_T100 Q4QQZ9_XENLA MGC115450 protein Xenopus laevis (African clawed frog) 110 100.00% Srp14 ARP40454_T100 A2VDD5_XENLA LOC100037226 protein (Fragment) Xenopus laevis (African clawed frog) 109 92.00%

Mediator of RNA polymerase II transcription subunit 27 (Cofactor required for Sp1 transcriptional activation subunit 8) (CRSP complex subunit 8) (Mediator complex Xenopus tropicalis (Western clawed frog) crsp8 ARP38444_T100 MED27_XENTR subunit 27) (Silurana tropicalis) 311 100.00%

Mediator of RNA polymerase II transcription subunit 27‐B (Cofactor required for Sp1 transcriptional activation subunit 8‐B) (CRSP complex subunit 8‐B) (Mediator complex crsp8 ARP38444_T100 MD27B_XENLA subunit 27‐B) Xenopus laevis (African clawed frog) 311 100.00% Mediator of RNA polymerase II transcription subunit 27‐A (Cofactor required for Sp1 transcriptional activation subunit 8‐A) (CRSP complex subunit 8‐A) (Mediator complex crsp8 ARP38444_T100 MD27A_XENLA subunit 27‐A) Xenopus laevis (African clawed frog) 311 100.00% BMPER ARP52569_P050 Q3L0X4_XENLA Crossveinless‐2 Xenopus laevis (African clawed frog) 687 85.00% Xenopus tropicalis (Western clawed frog) BMPER ARP52569_P050 Q3L0X3_XENTR Crossveinless‐2 (Silurana tropicalis) 687 78.00% Xenopus tropicalis (Western clawed frog) BMPER ARP52569_P050 A4II63_XENTR Bmper protein (Silurana tropicalis) 646 78.00% Xenopus tropicalis (Western clawed frog) ifrd2 ARP54585_P050 Q0IHQ2_XENTR Interferon‐related developmental regulator 1 (Silurana tropicalis) 426 83.00% ifrd2 ARP54585_P050 Q6PF29_XENLA MGC69123 protein Xenopus laevis (African clawed frog) 425 83.00% ifrd2 ARP54585_P050 Q5XK75_XENLA LOC494857 protein Xenopus laevis (African clawed frog) 284 83.00% Xenopus tropicalis (Western clawed frog) Bbs5 ARP52931_P050 A4IHK9_XENTR Bardet‐Biedl syndrome 5 (Silurana tropicalis) 342 92.00% ARP42456_P050 Q6DFC5_XENLA Abhd5‐prov protein Xenopus laevis (African clawed frog) 361 84.00% Xenopus tropicalis (Western clawed frog) ARP42456_P050 Q5BKI2_XENTR Abhydrolase domain containing 5 (Silurana tropicalis) 371 84.00% Xenopus tropicalis (Western clawed frog) ARP42456_P050 Q28DW4_XENTR Abhydrolase domain containing 5 (Silurana tropicalis) 371 84.00% Xenopus tropicalis (Western clawed frog) NAT1 ARP40362_P050 Q6DIH1_XENTR MGC89536 protein (Silurana tropicalis) 894 78.00% NAT1 ARP40362_P050 Q5KTT8_XENLA EIF4G‐related protein NAT1 Xenopus laevis (African clawed frog) 903 78.00% ARP32563_T100 Q7ZX88_XENLA MGC53332 protein Xenopus laevis (African clawed frog) 906 92.00% Xenopus tropicalis (Western clawed frog) ARP32563_T100 Q6P4X4_XENTR Staphylococcal nuclease domain containing 1 (Silurana tropicalis) 885 92.00% ARP32563_T100 Q7ZY98_XENLA 2e999‐prov protein Xenopus laevis (African clawed frog) 906 78.00% ORF Names:MED134_00590 EMBL EAQ39071.1OrganismDokdonia donghaensis MED134 ARP54997_P050 Q5U235_XENLA LOC495699 protein Xenopus laevis (African clawed frog) 1206 85.00% ORF Names:MED134_00590 EMBL EAQ39071.1OrganismDokdonia Xenopus tropicalis (Western clawed frog) donghaensis MED134 ARP54997_P050 B2GUA0_XENTR LOC100158535 protein (Silurana tropicalis) 1209 85.00% PMM1 ARP56401_P050 Q6GNE0_XENLA MGC82869 protein Xenopus laevis (African clawed frog) 260 92.00% Xenopus tropicalis (Western clawed frog) PMM1 ARP56401_P050 B5DEB2_XENTR Putative uncharacterized protein (Silurana tropicalis) 260 84.00% PMM1 ARP56401_P050 Q5U4M6_XENLA LOC495465 protein Xenopus laevis (African clawed frog) 260 91.00%

ORF Names:v1g177328OrganismNematostel Xenopus tropicalis (Western clawed frog) la vectensis (Starlet sea anemone) ARP53791_P050 B1H3I9_XENTR LOC100145643 protein (Fragment) (Silurana tropicalis) 675 100.00% MMP‐9TH ARP33090_T100 Q8UUZ3_XENLA Matrix metalloproteinase Xenopus laevis (African clawed frog) 656 100.00% MMP‐9TH ARP33090_T100 Q7SYA5_XENLA Mmp2 protein Xenopus laevis (African clawed frog) 559 100.00% MMP‐9TH ARP33090_T100 Q6GQI1_XENLA Mmp2‐prov protein (Fragment) Xenopus laevis (African clawed frog) 595 100.00%

Matrix metallopeptidase 2 (Gelatinase A, Xenopus tropicalis (Western clawed frog) MMP‐9TH ARP33090_T100 Q5FVW8_XENTR 72kDa gelatinase, 72kDa type 4 collagenase) (Silurana tropicalis) 655 100.00%

Matrix metallopeptidase 9 (Gelatinase B, Xenopus tropicalis (Western clawed frog) MMP‐9TH ARP33090_T100 Q6DF16_XENTR 92kDa gelatinase, 92kDa type IV collagenase) (Silurana tropicalis) 670 92.00% MMP‐9TH ARP33090_T100 A2VCV4_XENLA Mmp‐9th protein Xenopus laevis (African clawed frog) 674 92.00% MMP‐9TH ARP33090_T100 A1ILK1_XENLA Matrix metalloproteinase‐9TH Xenopus laevis (African clawed frog) 683 92.00% MMP‐9TH ARP33090_T100 Q9W7L6_XENLA Gelatinase B Xenopus laevis (African clawed frog) 671 85.00% MMP‐9TH ARP33090_T100 Q6PF33_XENLA Mmp9 protein Xenopus laevis (African clawed frog) 671 85.00% MMP‐9TH ARP33090_T100 Q10833_XENLA Collagenase‐3 Xenopus laevis (African clawed frog) 472 91.00%

Collagenase 3 (EC 3.4.24.‐) (Matrix MMP‐9TH ARP33090_T100 MMP13_XENLA metalloproteinase‐13) (MMP‐13) (Fragment) Xenopus laevis (African clawed frog) 469 91.00% Xenopus tropicalis (Western clawed frog) MMP‐9TH ARP33090_T100 B1H2C5_XENTR LOC100145387 protein (Silurana tropicalis) 476 78.00% MGC143103 ARP42348_T100 Q63ZP4_XENLA LOC494764 protein Xenopus laevis (African clawed frog) 146 75.00% Xenopus tropicalis (Western clawed frog) MGC143103 ARP42348_T100 B2RY99_XENTR Fam107a protein (Silurana tropicalis) 146 75.00% C1QT4 ARP52425_P050 Q68ET4_XENLA MGC84713 protein Xenopus laevis (African clawed frog) 324 92.00% Xenopus tropicalis (Western clawed frog) C1QT4 ARP52425_P050 Q5M7R1_XENTR Hypothetical LOC496809 (Silurana tropicalis) 374 91.00% Associated molecule with the SH3 domain of Xenopus tropicalis (Western clawed frog) minE ARP53526_P050 Q6P841_XENTR STAM (AMSH) like protein (Silurana tropicalis) 429 78.00% Xenopus tropicalis (Western clawed frog) FOXB1 ARP35850_P050 B0JZ54_XENTR Foxb1 protein (Silurana tropicalis) 322 80.00% Forkhead box protein B1 (FoxB1) FOXB1 ARP35850_P050 FOXB1_XENLA (Transcription factor FKH‐5) Xenopus laevis (African clawed frog) 319 80.00% Testis expressed gene 27 (Zinc finger, AN1‐ Xenopus tropicalis (Western clawed frog) ZFAN3 ARP39517_P050 Q28HC1_XENTR type domain 3) (Silurana tropicalis) 225 100.00% ZFAN3 ARP39517_P050 ZFAN3_XENLA AN1‐type zinc finger protein 3 homolog Xenopus laevis (African clawed frog) 226 100.00% Xenopus tropicalis (Western clawed frog) Dmap1 ARP32917_T100 Q6DK89_XENTR DNA methyltransferase 1 associated protein 1 (Silurana tropicalis) 464 92.00% Dmap1 ARP32917_T100 Q641D1_XENLA MGC82015 protein Xenopus laevis (African clawed frog) 464 92.00% ORF Names:PANDA_004233 EMBL EFB13731.1OrganismAiluropoda Histone‐lysine N‐methyltransferase SETD7 (EC Xenopus tropicalis (Western clawed frog) melanoleuca (Giant panda) ARP48940_T100 SETD7_XENTR 2.1.1.43) (SET domain‐containing protein 7) (Silurana tropicalis) 366 78.00% ARP39211_P050 Q9PVP8_XENLA Champignon Xenopus laevis (African clawed frog) 470 78.00% ARP39211_P050 Q2VPN0_XENLA Zbtb7b protein Xenopus laevis (African clawed frog) 470 78.00% Probable proline dehydrogenase 2 (EC PRODH2 ARP41621_P050 PROD2_XENLA 1.5.99.8) (Probable proline oxidase 2) Xenopus laevis (African clawed frog) 466 91.00% Xenopus tropicalis (Western clawed frog) PRODH2 ARP41621_P050 Q5M8F5_XENTR Prodh2‐prov protein (Fragment) (Silurana tropicalis) 458 83.00% NOMO3 ARP54998_P050 Q5U235_XENLA LOC495699 protein Xenopus laevis (African clawed frog) 1206 78.00% Xenopus tropicalis (Western clawed frog) NOMO3 ARP54998_P050 B2GUA0_XENTR LOC100158535 protein (Silurana tropicalis) 1209 78.00% Hydroxyacyl‐Coenzyme A dehydrogenase/3‐ Ordered Locus ketoacyl‐Coenzyme A thiolase/enoyl‐ Names:Arth_2144OrganismArthrobacte Coenzyme A hydratase (Trifunctional protein), Xenopus tropicalis (Western clawed frog) r sp. (strain FB24) ARP48133_P050 Q6P8B9_XENTR beta subunit (Silurana tropicalis) 470 92.00%

Hydroxyacyl‐Coenzyme A dehydrogenase/3‐ Ordered Locus ketoacyl‐Coenzyme A thiolase/enoyl‐ Names:Arth_2144OrganismArthrobacte Coenzyme A hydratase (Trifunctional protein), Xenopus tropicalis (Western clawed frog) r sp. (strain FB24) ARP48133_P050 Q28CG3_XENTR beta subunit (Fragment) (Silurana tropicalis) 203 92.00% Ordered Locus Names:Arth_2144OrganismArthrobacte r sp. (strain FB24) ARP48133_P050 Q7ZTL0_XENLA Thiolase‐prov protein Xenopus laevis (African clawed frog) 470 92.00% Xenopus tropicalis (Western clawed frog) Cpne3 ARP40504_T100 Q66JK5_XENTR Cpne3 protein (Silurana tropicalis) 543 78.00% Cpne3 ARP40504_T100 Q5U4I6_XENLA LOC495505 protein (Fragment) Xenopus laevis (African clawed frog) 509 78.00% Cpne3 ARP40504_T100 Q3B8L6_XENLA LOC495505 protein Xenopus laevis (African clawed frog) 533 78.00% TMEM168 ARP49730_P050 TM168_XENLA Transmembrane protein 168 Xenopus laevis (African clawed frog) 700 100.00% Nfatc3 P100975_P050 Q8QHM1_XENLA Nuclear factor of activated T‐cell Xenopus laevis (African clawed frog) 884 91.00% Nfatc3 P100975_P050 B7ZQA4_XENLA Nuclear factor of activated T‐cell Xenopus laevis (African clawed frog) 884 91.00% Nfatc3 P100975_P050 B7ZQA2_XENLA Nuclear factor of activated T‐cell Xenopus laevis (African clawed frog) 884 91.00% Xenopus tropicalis (Western clawed frog) Nfatc3 P100975_P050 B4F6V2_XENTR Putative uncharacterized protein (Silurana tropicalis) 894 91.00% Xenopus tropicalis (Western clawed frog) roraa ARP45608_T100 Q08D40_XENTR RAR‐related orphan receptor A (Silurana tropicalis) 267 92.00% Eukaryotic translation initiation factor 3 Xenopus tropicalis (Western clawed frog) ARP48293_T100 EIF3M_XENTR subunit M (eIF3m) (Silurana tropicalis) 374 85.00% Eukaryotic translation initiation factor 3 ARP48293_T100 EIF3M_XENLA subunit M (eIF3m) Xenopus laevis (African clawed frog) 374 85.00% ARP32457_T100 Q6PA46_XENLA MGC68569 protein Xenopus laevis (African clawed frog) 949 92.00%

ORF Names:v1g105460OrganismNematostel la vectensis (Starlet sea anemone) ARP34022_P050 Q7SYS4_XENLA MGC64534 protein Xenopus laevis (African clawed frog) 263 78.00% ORF Names:v1g105460OrganismNematostel Xenopus tropicalis (Western clawed frog) la vectensis (Starlet sea anemone) ARP34022_P050 Q5HZD0_XENTR Chymotrypsinogen B1 (Silurana tropicalis) 263 78.00%

ORF Names:v1g105460OrganismNematostel la vectensis (Starlet sea anemone) ARP34022_P050 Q6GNF7_XENLA MGC82838 protein Xenopus laevis (African clawed frog) 263 76.00%

ORF Names:v1g105460OrganismNematostel la vectensis (Starlet sea anemone) ARP34022_P050 Q6PGS4_XENLA MGC64417 protein Xenopus laevis (African clawed frog) 263 78.00% ARP43484_P050 A1L2R6_XENLA LOC100036929 protein Xenopus laevis (African clawed frog) 498 84.00% ARP43484_P050 A1L2S7_XENLA LOC100036938 protein Xenopus laevis (African clawed frog) 356 85.00% ARP43484_P050 Q6DE39_XENLA Rnf30‐prov protein Xenopus laevis (African clawed frog) 356 78.00% Xenopus tropicalis (Western clawed frog) ARP43484_P050 Q0D2A2_XENTR Tripartite motif‐containing 63 (Silurana tropicalis) 348 78.00% ARP43484_P050 Q6INV6_XENLA MGC80214 protein Xenopus laevis (African clawed frog) 360 90.00% GTF2B P100989_P050 Q63ZH4_XENLA LOC494830 protein Xenopus laevis (African clawed frog) 316 85.00% General transcription factor IIBgeneral Xenopus tropicalis (Western clawed frog) GTF2B P100989_P050 Q28G23_XENTR transcription factor IIB (Silurana tropicalis) 316 85.00% Transcription initiation factor IIB (General GTF2B P100989_P050 TF2B_XENLA transcription factor TFIIB) Xenopus laevis (African clawed frog) 316 78.00% DBP5 ARP40299_T100 Q7ZWV1_XENLA Ddx19‐prov protein Xenopus laevis (African clawed frog) 487 100.00% Xenopus tropicalis (Western clawed frog) DBP5 ARP40299_T100 Q6P887_XENTR DEAD (Asp‐Glu‐Ala‐As) box polypeptide 19 (Silurana tropicalis) 487 100.00% ARP40629_P050 Q0PF19_XENLA N‐ethylmaleimide sensitive factor Xenopus laevis (African clawed frog) 746 78.00% Xenopus tropicalis (Western clawed frog) ARP40629_P050 Q0IJ19_XENTR N‐ethylmaleimide‐sensitive factor (Silurana tropicalis) 740 78.00% ARP54910_P050 Q7ZYG6_XENLA Txn2‐prov protein Xenopus laevis (African clawed frog) 170 92.00% Xenopus tropicalis (Western clawed frog) ARP54910_P050 Q641J6_XENTR Thioredoxin 2 (Txn2 protein) (Silurana tropicalis) 170 85.00% Xenopus tropicalis (Western clawed frog) ARP54910_P050 Q28F90_XENTR Thioredoxin 2 (Fragment) (Silurana tropicalis) 119 85.00% ARP34546_P050 CN166_XENLA UPF0568 protein C14orf166 homolog Xenopus laevis (African clawed frog) 240 100.00% ARP34546_P050 Q5M9B0_XENLA LOC496146 protein Xenopus laevis (African clawed frog) 240 92.00%

ORF Names:OsI_021120OrganismOryza sativa subsp. indica (Rice) ARP56312_P050 Q7ZTM2_XENLA Psma4‐prov protein Xenopus laevis (African clawed frog) 261 100.00%

ORF Names:OsI_021120OrganismOryza Proteasome endopeptidase complex chain sativa subsp. indica (Rice) ARP56312_P050 Q7LZF1_9PIPI XC9 (Clone 1) (EC 3.4.25.1) Xenopus sp. (clawed frog) 261 100.00% ORF Names:OsI_021120OrganismOryza Proteasome endopeptidase complex chain sativa subsp. indica (Rice) ARP56312_P050 Q7LZF0_9PIPI XC9 (Clone 2) (EC 3.4.25.1) (Fragment) Xenopus sp. (clawed frog) 194 100.00%

ORF Names:OsI_021120OrganismOryza Proteasome (Prosome macropain) subunit Xenopus tropicalis (Western clawed frog) sativa subsp. indica (Rice) ARP56312_P050 Q66JK8_XENTR alpha type 4 (Silurana tropicalis) 261 100.00%

ORF Names:OsI_021120OrganismOryza sativa subsp. indica (Rice) ARP56312_P050 Q3KPN6_XENLA MGC132180 protein Xenopus laevis (African clawed frog) 261 100.00% Xenopus tropicalis (Western clawed frog) ARP34543_P050 B7ZTC1_XENTR Transcription factor B1, mitochondrial (Silurana tropicalis) 346 92.00% Xenopus tropicalis (Western clawed frog) ARP34543_P050 B1H151_XENTR Tfb1m protein (Silurana tropicalis) 346 92.00% Dimethyladenosine transferase 1, mitochondrial (EC 2.1.1.‐) (Mitochondrial 12S rRNA dimethylase 1) (Mitochondrial transcription factor B1) (mtTFB1) (S‐ adenosylmethionine‐6‐N', N'‐adenosyl(rRNA) Xenopus tropicalis (Western clawed frog) ARP34543_P050 TFB1M_XENTR dimethyltransferase 1) (Silurana tropicalis) 346 92.00% Dimethyladenosine transferase 1, mitochondrial (EC 2.1.1.‐) (Mitochondrial 12S rRNA dimethylase 1) (Mitochondrial transcription factor B1) (mtTFB1) (S‐ adenosylmethionine‐6‐N', N'‐adenosyl(rRNA) ARP34543_P050 TFB1M_XENLA dimethyltransferase 1) Xenopus laevis (African clawed frog) 344 85.00% rhot1b ARP44819_P050 Q08AW2_XENLA Mitochondrial Rho GTPase (EC 3.6.5.‐) Xenopus laevis (African clawed frog) 618 85.00% 39S ribosomal protein L15, mitochondrial MRPL15 ARP46192_P050 RM15_XENLA (L15mt) (MRP‐L15) Xenopus laevis (African clawed frog) 296 84.00% ORF Names:CBG10287 WormBase CBG10287, CBG_10287 EMBL CAP29707.2OrganismCaenorhabditis briggsae ARP46614_T100 Q91671_XENLA P58 (Fragment) Xenopus laevis (African clawed frog) 421 76.00% ORF Names:CBG10287 WormBase CBG10287, CBG_10287 EMBL CAP29707.2OrganismCaenorhabditis briggsae ARP46614_T100 A1L3M9_XENLA Lman1‐a protein Xenopus laevis (African clawed frog) 509 76.00% ARP40281_T100 Q6DDP5_XENLA Ola1 protein Xenopus laevis (African clawed frog) 281 100.00% Xenopus tropicalis (Western clawed frog) ARP40281_T100 OLA1_XENTR Obg‐like ATPase 1 (EC 3.6.3.‐) (Silurana tropicalis) 396 100.00% ARP40281_T100 OLA1_XENLA Obg‐like ATPase 1 (EC 3.6.3.‐) Xenopus laevis (African clawed frog) 396 100.00% net1 ARP52123_P050 Q8AVF7_XENLA Net1‐prov protein Xenopus laevis (African clawed frog) 576 78.00% net1 ARP52123_P050 Q6INX8_XENLA Net1‐prov protein Xenopus laevis (African clawed frog) 520 78.00% net1 ARP52123_P050 Q6INM1_XENLA MGC82365 protein Xenopus laevis (African clawed frog) 522 78.00% Xenopus tropicalis (Western clawed frog) net1 ARP52123_P050 A0JM16_XENTR Neuroepithelial cell transforming 1 (Silurana tropicalis) 579 78.00% Transcription factor HES‐1 (Hairy and Xenopus tropicalis (Western clawed frog) her9 ARP32372_T100 HES1_XENTR enhancer of split 1) (Protein hairy‐1) (Silurana tropicalis) 267 100.00% Transcription factor HES‐1‐B (Hairy and her9 ARP32372_T100 HES1B_XENLA enhancer of split 1‐B) Xenopus laevis (African clawed frog) 267 100.00% Transcription factor HES‐1‐A (Hairy and enhancer of split 1‐A) (Protein hairy‐1) (Xhairy‐ her9 ARP32372_T100 HES1A_XENLA 1) (Xhairy1) (Xlh1) Xenopus laevis (African clawed frog) 267 100.00% Transcription factor HES‐4 (Hairy and Xenopus tropicalis (Western clawed frog) her9 ARP32372_T100 HES4_XENTR enhancer of split 4) (Protein hairy‐2) (Silurana tropicalis) 281 92.00% Transcription factor HES‐4‐B (Hairy and enhancer of split 4‐B) (Protein hairy‐2) her9 ARP32372_T100 HES4B_XENLA (Xhairy2) (Protein hairy‐2a) (Xhairy2b) Xenopus laevis (African clawed frog) 277 92.00% Transcription factor HES‐4‐A (Hairy and enhancer of split 4‐A) (Protein hairy‐2) her9 ARP32372_T100 HES4A_XENLA (Xhairy2) (Protein hairy‐2a) (Xhairy2a) Xenopus laevis (African clawed frog) 281 92.00% Atlastin‐2 (EC 3.6.5.‐) (ADP‐ribosylation factor‐ like protein 6‐interacting protein 2) (ARL‐6‐ ATL2 ARP49718_P050 ATLA2_XENLA interacting protein 2) (Aip‐2) Xenopus laevis (African clawed frog) 569 100.00% Xenopus tropicalis (Western clawed frog) PTPN1 ARP45360_P050 B1H2K9_XENTR Putative uncharacterized protein (Silurana tropicalis) 433 92.00% PTPN1 ARP45360_P050 Q6GMA0_XENLA MGC81984 protein Xenopus laevis (African clawed frog) 428 85.00% Xenopus tropicalis (Western clawed frog) WDR63 ARP52800_P050 B1H2Z0_XENTR LOC100145513 protein (Silurana tropicalis) 896 76.00% Myeloid/lymphoid or mixed‐lineage leukemia (Trithorax homolog, Drosophila); translocated Xenopus tropicalis (Western clawed frog) Mllt3 ARP38490_P050 Q28ED2_XENTR to, 3 (Silurana tropicalis) 571 100.00% Mllt3 ARP38490_P050 Q68EY8_XENLA MGC84026 protein Xenopus laevis (African clawed frog) 550 92.00% Mllt3 ARP38490_P050 Q640I2_XENLA LOC494666 protein Xenopus laevis (African clawed frog) 552 92.00% Xenopus tropicalis (Western clawed frog) Mllt3 ARP38490_P050 B2GUE9_XENTR LOC100158574 protein (Silurana tropicalis) 554 92.00% Mllt3 ARP38490_P050 A5PKM5_XENLA Hypothetical LOC494666 Xenopus laevis (African clawed frog) 552 92.00% Limd1 ARP50563_P050 Q06BR1_XENLA LIM domains‐containing protein 1 Xenopus laevis (African clawed frog) 612 78.00% Xenopus tropicalis (Western clawed frog) ARP54630_P050 A4IGY7_XENTR LOC100038283 protein (Silurana tropicalis) 354 85.00% Guanine nucleotide‐binding protein G(i) subunit alpha‐1 (Adenylate cyclase‐inhibiting ARP54630_P050 GNAI1_XENLA G alpha protein) Xenopus laevis (African clawed frog) 354 85.00% Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide Xenopus tropicalis (Western clawed frog) ARP54630_P050 Q5I080_XENTR 3 (Silurana tropicalis) 354 78.00% ARP54630_P050 Q6DJF3_XENLA MGC84412 protein Xenopus laevis (African clawed frog) 354 75.00% Xenopus tropicalis (Western clawed frog) LOC100145426 ARP54422_P050 B1H2G9_XENTR LOC100145426 protein (Silurana tropicalis) 304 92.00% myst2 ARP31518_P050 Q6GPW8_XENLA MGC68869 protein Xenopus laevis (African clawed frog) 617 85.00% myst2 ARP31518_P050 Q6AZV6_XENLA Myst2 protein Xenopus laevis (African clawed frog) 553 85.00% Xenopus tropicalis (Western clawed frog) myst2 ARP31518_P050 A4IGQ4_XENTR Myst2 protein (Silurana tropicalis) 558 85.00% myst2 ARP31518_P050 Q6PCK3_XENLA MGC68869 protein Xenopus laevis (African clawed frog) 535 84.00% Xenopus tropicalis (Western clawed frog) myst2 ARP31518_P050 Q28CF9_XENTR Myst histone acetyltransferase 2 (Silurana tropicalis) 535 84.00% ORF Names:LMED105_05327 EMBL EDM84944.1OrganismLimnobacter sp. Xenopus tropicalis (Western clawed frog) MED105 ARP40181_P050 A9JTQ6_XENTR Homer1 protein (Silurana tropicalis) 355 92.00% ORF Names:LMED105_05327 EMBL EDM84944.1OrganismLimnobacter sp. MED105 ARP40181_P050 Q5I2P4_XENLA Homer 1b‐1 Xenopus laevis (African clawed frog) 355 78.00% ORF Names:LMED105_05327 EMBL EDM84944.1OrganismLimnobacter sp. MED105 ARP40181_P050 B7ZRW1_XENLA Homer 1b‐1 Xenopus laevis (African clawed frog) 355 78.00% Xenopus tropicalis (Western clawed frog) Nacc2 ARP34627_T100 A4QNP8_XENTR LOC100125188 protein (Silurana tropicalis) 577 100.00% ARP53577_P050 Q7ZYG7_XENLA Ap2b1‐prov protein Xenopus laevis (African clawed frog) 951 100.00% Adaptor‐related protein complex 2, beta 1 Xenopus tropicalis (Western clawed frog) ARP53577_P050 Q6P4L7_XENTR subunit (Silurana tropicalis) 951 100.00% ptgs1 ARP41836_P050 B7ZRV2_XENLA 1 Xenopus laevis (African clawed frog) 587 84.00% ptgs1 ARP41836_P050 A0A9J3_XENLA Cyclooxygenase 1 Xenopus laevis (African clawed frog) 587 84.00% Prostaglandin‐endoperoxide synthase 2 (Prostaglandin G/H synthase and Xenopus tropicalis (Western clawed frog) ptgs1 ARP41836_P050 Q501R2_XENTR cyclooxygenase) (Silurana tropicalis) 604 76.00% ARP40464_T100 Q6PAE3_XENLA MGC68448 protein Xenopus laevis (African clawed frog) 805 92.00% ARP40464_T100 Q7ZTB3_XENLA Heat shock protein gp96 Xenopus laevis (African clawed frog) 804 85.00%

Heat shock protein 90kDa beta (Grp94), Xenopus tropicalis (Western clawed frog) ARP40464_T100 Q28BS3_XENTR member 1 (Tumor rejection antigen (Gp96) 1) (Silurana tropicalis) 803 85.00% ARP40464_T100 A2VD63_XENLA Putative uncharacterized protein Xenopus laevis (African clawed frog) 805 85.00% sulf2 ARP49338_T100 Q5XGR2_XENLA LOC495271 protein (Fragment) Xenopus laevis (African clawed frog) 193 78.00% sulf2 ARP49338_T100 A1L102_XENLA LOC495271 protein Xenopus laevis (African clawed frog) 872 78.00% ARP54893_P050 Q6INB2_XENLA MGC84500 protein Xenopus laevis (African clawed frog) 272 78.00% ARP54893_P050 Q6DD01_XENLA Pitpnb‐prov protein Xenopus laevis (African clawed frog) 271 78.00% Xenopus tropicalis (Western clawed frog) ARP54893_P050 Q05B20_XENTR Putative uncharacterized protein MGC146613 (Silurana tropicalis) 272 78.00% ywhag1 ARP54792_P050 Q8AVW5_XENLA Ywhaz‐prov protein Xenopus laevis (African clawed frog) 245 78.00% ywhag1 ARP54792_P050 Q6PGS3_XENLA Ywhaz protein Xenopus laevis (African clawed frog) 245 78.00% ywhag1 ARP54792_P050 Q6DJE2_XENLA MGC84451 protein Xenopus laevis (African clawed frog) 247 78.00% Tyrosine 3‐monooxygenase/tryptophan 5‐ monooxygenase activation protein, epsilon Xenopus tropicalis (Western clawed frog) ywhag1 ARP54792_P050 Q66IF5_XENTR polypeptide (Silurana tropicalis) 255 78.00% Tyrosine 3‐monooxygenase/tryptophan 5‐ monooxygenase activation protein, eta Xenopus tropicalis (Western clawed frog) ywhag1 ARP54792_P050 Q28DR3_XENTR polypeptide (Silurana tropicalis) 247 78.00% Tyrosine 3‐monooxygenase/tryptophan 5‐ monooxygenase activation protein, gamma Xenopus tropicalis (Western clawed frog) ywhag1 ARP54792_P050 Q0V9W8_XENTR polypeptide (Silurana tropicalis) 247 78.00% ywhag1 ARP54792_P050 O57468_XENLA 14‐3‐3 protein epsilon (Ywhae‐prov protein) Xenopus laevis (African clawed frog) 255 78.00% Xenopus tropicalis (Western clawed frog) Actn1 ARP41914_P050 B4F6M1_XENTR Putative uncharacterized protein (Silurana tropicalis) 896 92.00% Actn1 ARP41914_P050 Q6DFU3_XENLA Actn3‐prov protein Xenopus laevis (African clawed frog) 896 85.00% Actn1 ARP41914_P050 Q7ZY34_XENLA ACTN1 protein Xenopus laevis (African clawed frog) 890 84.00% Actn1 ARP41914_P050 Q6NRW6_XENLA MGC81191 protein Xenopus laevis (African clawed frog) 890 84.00% Xenopus tropicalis (Western clawed frog) Actn1 ARP41914_P050 Q05AR8_XENTR Actinin, alpha 1 (Silurana tropicalis) 885 84.00% Xenopus tropicalis (Western clawed frog) Actn1 ARP41914_P050 B4F6H3_XENTR Putative uncharacterized protein (Silurana tropicalis) 298 84.00% Actn1 ARP41914_P050 Q6IP14_XENLA MGC79034 protein Xenopus laevis (African clawed frog) 894 83.00% Xenopus tropicalis (Western clawed frog) Actn1 ARP41914_P050 Q6DF05_XENTR Actinin, alpha 2 (Silurana tropicalis) 894 83.00% Actn1 ARP41914_P050 Q6DD73_XENLA MGC79035 protein Xenopus laevis (African clawed frog) 894 83.00% Xenopus tropicalis (Western clawed frog) hulA ARP43089_P050 Q0VA08_XENTR Wwp2 protein (Silurana tropicalis) 729 92.00% Xenopus tropicalis (Western clawed frog) hulA ARP43089_P050 Q0P4P5_XENTR Wwp1 protein (Silurana tropicalis) 914 92.00% Xenopus tropicalis (Western clawed frog) hulA ARP43089_P050 A0JM32_XENTR Itchy E3 ubiquitin protein ligase homolog (Silurana tropicalis) 853 92.00% hulA ARP43089_P050 Q6GMD5_XENLA Nedd4 protein Xenopus laevis (African clawed frog) 971 78.00% Neural cell expressed, developmentally down‐ Xenopus tropicalis (Western clawed frog) hulA ARP43089_P050 Q6DIR6_XENTR regulated 4‐like (Silurana tropicalis) 970 78.00% hulA ARP43089_P050 O42573_XENLA Nedd4 protein Xenopus laevis (African clawed frog) 971 78.00% Ordered Locus Names:Shewana3_1405OrganismShew anella sp. (strain ANA‐3) ARP54442_P050 Q6PBB7_XENLA MGC68596 protein Xenopus laevis (African clawed frog) 254 100.00% Ordered Locus Names:Shewana3_1405OrganismShew Electron‐transfer‐, beta Xenopus tropicalis (Western clawed frog) anella sp. (strain ANA‐3) ARP54442_P050 Q6P7K1_XENTR polypeptide (Silurana tropicalis) 254 100.00%

Mediator of RNA polymerase II transcription Xenopus tropicalis (Western clawed frog) MED6 ARP34220_P050 B3DLE4_XENTR subunit 6 (Mediator complex subunit 6) (Silurana tropicalis) 246 78.00% E3 ubiquitin‐protein ligase CHFR (EC 6.3.2.‐) (Checkpoint with forkhead and RING finger Xenopus tropicalis (Western clawed frog) chfr ARP43250_P050 CHFR_XENTR domains protein) (Silurana tropicalis) 626 85.00% E3 ubiquitin‐protein ligase CHFR (EC 6.3.2.‐) (Checkpoint with forkhead and RING finger chfr ARP43250_P050 CHFR_XENLA domains protein) Xenopus laevis (African clawed frog) 625 85.00% Ordered Locus Names:RB2501_04505OrganismRobigin italea biformata (strain ATCC BAA‐864 / HTCC2501 / KCTC 12146) ARP55734_P050 A1L2M8_XENLA LOC100036896 protein Xenopus laevis (African clawed frog) 410 78.00%

NR2B ARP35015_P050 A9QW73_XENLA N‐methyl‐D‐aspartate receptor subunit NR2B Xenopus laevis (African clawed frog) 1449 78.00%

NR2B ARP35015_P050 A7XY94_XENLA Ionotropic glutamate receptor subunit NR2B Xenopus laevis (African clawed frog) 1448 78.00% ORF Names:CG8026 FlyBase FBgn0033391, Dmel_CG8026 EMBL AAF58969.1OrganismDrosophila melanogaster ( ) ARP44049_P050 Q5PQ46_XENLA LOC495984 protein Xenopus laevis (African clawed frog) 318 100.00% ORF Names:CG8026 FlyBase FBgn0033391, Dmel_CG8026 EMBL AAF58969.1OrganismDrosophila Xenopus tropicalis (Western clawed frog) melanogaster (Fruit fly) ARP44049_P050 Q0VFE5_XENTR Slc25a32 protein (Fragment) (Silurana tropicalis) 325 100.00% ORF Names:CG8026 FlyBase FBgn0033391, Dmel_CG8026 EMBL AAF58969.1OrganismDrosophila Xenopus tropicalis (Western clawed frog) melanogaster (Fruit fly) ARP44049_P050 A9ULD2_XENTR Slc25a32 protein (Silurana tropicalis) 322 100.00% metap2l ARP52266_P050 Q7ZY93_XENLA Metap2‐prov protein Xenopus laevis (African clawed frog) 462 84.00% Methionine aminopeptidase 2 (Putative Xenopus tropicalis (Western clawed frog) metap2l ARP52266_P050 Q28F92_XENTR uncharacterized protein LOC548869) (Silurana tropicalis) 483 84.00% metap2l ARP52266_P050 Q6GNF9_XENLA LOC443662 protein (Fragment) Xenopus laevis (African clawed frog) 480 76.00% metap2l ARP52266_P050 Q0P3Q4_XENLA LOC443662 protein Xenopus laevis (African clawed frog) 481 76.00% ORF Names:PANDA_005024 EMBL EFB19973.1OrganismAiluropoda melanoleuca (Giant panda) ARP57949_P050 A1L3J8_XENLA LOC100037026 protein Xenopus laevis (African clawed frog) 258 85.00%

ORF Names:AGAP006386OrganismAnophel es gambiae (African malaria mosquito) P100708_P050 Q9PVZ1_XENLA C‐Jun protein Xenopus laevis (African clawed frog) 312 100.00%

ORF Names:AGAP006386OrganismAnophel es gambiae (African malaria mosquito) P100708_P050 Q9PVZ0_XENLA C‐Jun protein Xenopus laevis (African clawed frog) 314 100.00% ORF Names:AGAP006386OrganismAnophel es gambiae (African malaria mosquito) P100708_P050 Q8AVE4_XENLA Jun protein Xenopus laevis (African clawed frog) 312 100.00%

ORF Names:AGAP006386OrganismAnophel es gambiae (African malaria mosquito) P100708_P050 Q6GLS7_XENLA C‐Jun protein Xenopus laevis (African clawed frog) 314 100.00%

ORF Names:AGAP006386OrganismAnophel es gambiae (African malaria mosquito) P100708_P050 Q68FJ3_XENLA MGC86303 protein Xenopus laevis (African clawed frog) 299 78.00%

ORF Names:AGAP006386OrganismAnophel Xenopus tropicalis (Western clawed frog) es gambiae (African malaria mosquito) P100708_P050 Q28IY7_XENTR Jun B proto‐oncogene (Silurana tropicalis) 307 78.00% Tyrosine 3‐monooxygenase/tryptophan 5‐ monooxygenase activation protein, epsilon Xenopus tropicalis (Western clawed frog) AVARP02058_P050 Q66IF5_XENTR polypeptide (Silurana tropicalis) 255 92.00%

AVARP02058_P050 O57468_XENLA 14‐3‐3 protein epsilon (Ywhae‐prov protein) Xenopus laevis (African clawed frog) 255 92.00% Ribosome biogenesis protein wdr12 (WD Xenopus tropicalis (Western clawed frog) ARP41317_T100 WDR12_XENTR repeat‐containing protein 12) (Silurana tropicalis) 423 78.00% ARP40975_P050 RBM26_XENLA Isoform 2 Xenopus laevis (African clawed frog) 1057 85.00% RNA‐binding protein 26 (RNA‐binding motif ARP40975_P050 RBM26_XENLA protein 26) Xenopus laevis (African clawed frog) 1059 85.00% Xenopus tropicalis (Western clawed frog) ARP41334_P050 Q27JK7_XENTR ADAM12 (Silurana tropicalis) 925 78.00% Xenopus tropicalis (Western clawed frog) GK10294 ARP33194_P050 B1H2T9_XENTR Putative uncharacterized protein (Silurana tropicalis) 268 76.00%

GK10294 ARP33194_P050 GATD1_XENLA GATA zinc finger domain‐containing protein 1 Xenopus laevis (African clawed frog) 245 76.00% Hepatocyte nuclear factor 4‐alpha (HNF‐4‐ alpha) (Nuclear receptor subfamily 2 group A Hnf4a ARP45595_P050 HNF4A_XENLA member 1) Xenopus laevis (African clawed frog) 464 92.00% ORF Names:PANDA_006241 EMBL EFB23919.1OrganismAiluropoda melanoleuca (Giant panda) ARP35158_P050 Q9PVD1_XENLA Kv3.1 potassium channel Xenopus laevis (African clawed frog) 592 85.00% ORF Names:ZK849.2 WormPep ZK849.2c WormBase WBGene00014101 WormBase ZK849.2c, ZK849.2c EMBL CAN86628.1OrganismCaenorhabditis elegans ARP56214_P050 Q6PG52_XENLA LOC398721 protein (Fragment) Xenopus laevis (African clawed frog) 133 100.00%

Polyadenylate‐binding protein‐interacting protein 1 (PABP‐interacting protein 1) (PAIP‐1) (Paip1 protein) (Poly(A)‐binding protein‐ PAIP1 ARP40651_T100 PAIP1_XENLA interacting protein 1) (XlPaip1) Xenopus laevis (African clawed frog) 463 92.00%

Ordered Locus Names:Shew_2445OrganismShewanell Xenopus tropicalis (Western clawed frog) a loihica (strain ATCC BAA‐1088 / PV‐4) ARP41041_T100 B1WAV6_XENTR LOC100145715 protein (Silurana tropicalis) 580 92.00%

Ordered Locus Names:Shew_2445OrganismShewanell Eukaryotic translation initiation factor 2A (eIF‐ a loihica (strain ATCC BAA‐1088 / PV‐4) ARP41041_T100 EIF2A_XENLA 2A) Xenopus laevis (African clawed frog) 582 92.00% Iroquois‐class homeodomain protein irx‐1 Xenopus tropicalis (Western clawed frog) IRX3 ARP33572_T100 IRX1_XENTR (Iroquois homeobox protein 1) (Silurana tropicalis) 467 100.00% Iroquois‐class homeodomain protein irx‐1‐B IRX3 ARP33572_T100 IRX1B_XENLA (Iroquois homeobox protein 1‐B) Xenopus laevis (African clawed frog) 462 100.00% Iroquois‐class homeodomain protein irx‐1‐A (Iroquois homeobox protein 1‐A) (Xiro‐1) IRX3 ARP33572_T100 IRX1A_XENLA (Xiro1) Xenopus laevis (African clawed frog) 467 100.00% Xenopus tropicalis (Western clawed frog) IRX3 ARP33572_T100 B3DLQ9_XENTR LOC100170530 protein (Silurana tropicalis) 454 92.00% Iroquois‐class homeodomain protein irx‐3 Xenopus tropicalis (Western clawed frog) IRX3 ARP33572_T100 IRX3_XENTR (Iroquois homeobox protein 3) (Silurana tropicalis) 448 92.00% Iroquois‐class homeodomain protein irx‐3 IRX3 ARP33572_T100 IRX3_XENLA (Iroquois homeobox protein 3) (Xiro3) Xenopus laevis (African clawed frog) 448 92.00% SUFU ARP33018_P050 Q6GN20_XENLA MGC83625 protein Xenopus laevis (African clawed frog) 474 92.00% Xenopus tropicalis (Western clawed frog) SUFU ARP33018_P050 B3DLW7_XENTR Sufu protein (Silurana tropicalis) 474 92.00% MPPED2 ARP41957_P050 Q6GLV7_XENLA MGC84179 protein Xenopus laevis (African clawed frog) 294 100.00% Novel calcineurin‐like phosphoesterase Xenopus tropicalis (Western clawed frog) MPPED2 ARP41957_P050 Q28GP2_XENTR (Ortholog of c11orf8) (Silurana tropicalis) 294 100.00% Eukaryotic translation initiation factor 3 subunit L (eIF3l) (Eukaryotic translation initiation factor 3 subunit 6‐interacting protein) (Eukaryotic translation initiation Xenopus tropicalis (Western clawed frog) EIF3L ARP48352_P050 EIF3L_XENTR factor 3 subunit E‐interacting protein) (Silurana tropicalis) 562 100.00%

Eukaryotic translation initiation factor 3 subunit L (eIF3l) (Eukaryotic translation initiation factor 3 subunit 6‐interacting protein) (Eukaryotic translation initiation EIF3L ARP48352_P050 EIF3L_XENLA factor 3 subunit E‐interacting protein) Xenopus laevis (African clawed frog) 562 100.00% TRAF4 AVARP09010_P050 Q68F27_XENLA MGC82199 protein Xenopus laevis (African clawed frog) 470 100.00% TRAF4 AVARP09010_P050 Q6DFG9_XENLA MGC83213 protein Xenopus laevis (African clawed frog) 470 100.00% Xenopus tropicalis (Western clawed frog) TRAF4 AVARP09010_P050 Q6DEV2_XENTR TNF receptor‐associated factor 4 (Silurana tropicalis) 470 100.00% Xenopus tropicalis (Western clawed frog) TRAF4 AVARP09010_P050 B4F6Z3_XENTR Traf4 protein (Fragment) (Silurana tropicalis) 247 100.00% ARP49025_P050 Q8QHK7_XENLA MAPK kinase 7 (Map2k7‐A protein) Xenopus laevis (African clawed frog) 417 100.00% Xenopus tropicalis (Western clawed frog) ARP49025_P050 Q4QQQ5_XENTR Mitogen‐activated protein kinase kinase 7 (Silurana tropicalis) 433 100.00% NOX1 ARP46818_P050 Q6GNG7_XENLA MGC82815 protein Xenopus laevis (African clawed frog) 570 78.00% Xenopus tropicalis (Western clawed frog) NOX1 ARP46818_P050 Q505H9_XENTR Cytochrome b‐245, beta polypeptide (Silurana tropicalis) 570 78.00% Xenopus tropicalis (Western clawed frog) SFXN1 ARP49750_P050 Q28FS9_XENTR Sideroflexin 1 (Sideroflexin 3) (Silurana tropicalis) 322 84.00% SFXN1 ARP49750_P050 Q0IHC3_XENLA MGC154458 protein Xenopus laevis (African clawed frog) 322 84.00%

ORF Names:DKEY‐267I17.1‐001 EMBL CAM15799.1OrganismDanio rerio (Zebrafish) (Brachydanio rerio) ARP57880_P050 Q68KF9_XENLA Subtilisin‐like kinase SPC4 Xenopus laevis (African clawed frog) 911 92.00%

ORF Names:DKEY‐267I17.1‐001 EMBL CAM15799.1OrganismDanio rerio (Zebrafish) (Brachydanio rerio) ARP57880_P050 Q5G5T9_XENLA PACE4AIIa Xenopus laevis (African clawed frog) 911 92.00%

ORF Names:DKEY‐267I17.1‐001 EMBL CAM15799.1OrganismDanio rerio (Zebrafish) (Brachydanio rerio) ARP57880_P050 Q5G5T8_XENLA PACE4AIIb Xenopus laevis (African clawed frog) 789 92.00%

ORF Names:DKEY‐267I17.1‐001 EMBL CAM15799.1OrganismDanio rerio (Zebrafish) (Brachydanio rerio) ARP57880_P050 Q68KF8_XENLA Spc6A protein (Subtilisin‐like protease SPC6A) Xenopus laevis (African clawed frog) 911 92.00% ORF Names:DKEY‐267I17.1‐001 EMBL CAM15799.1OrganismDanio rerio (Zebrafish) (Brachydanio rerio) ARP57880_P050 Q5PQ96_XENLA LOC495940 protein Xenopus laevis (African clawed frog) 911 92.00%

ORF Names:DKEY‐267I17.1‐001 EMBL CAM15799.1OrganismDanio rerio (Zebrafish) (Brachydanio rerio) ARP57880_P050 Q5EE49_XENLA Proprotein convertase 6A Xenopus laevis (African clawed frog) 911 92.00%

ORF Names:DKEY‐267I17.1‐001 EMBL CAM15799.1OrganismDanio rerio (Zebrafish) (Brachydanio rerio) ARP57880_P050 Q5EE48_XENLA Proprotein convertase 6B Xenopus laevis (African clawed frog) 1849 92.00%

ORF Names:DKEY‐267I17.1‐001 EMBL CAM15799.1OrganismDanio rerio (Zebrafish) (Brachydanio rerio) ARP57880_P050 Q5EE47_XENLA Proprotein convertase 6C Xenopus laevis (African clawed frog) 1632 92.00%

ORF Names:DKEY‐267I17.1‐001 EMBL CAM15799.1OrganismDanio rerio (Zebrafish) (Brachydanio rerio) ARP57880_P050 Q5EE46_XENLA Proprotein convertase 6D Xenopus laevis (African clawed frog) 1546 92.00%

ORF Names:DKEY‐267I17.1‐001 EMBL CAM15799.1OrganismDanio rerio (Zebrafish) (Brachydanio rerio) ARP57880_P050 Q5EE45_XENLA Proprotein convertase 6E Xenopus laevis (African clawed frog) 1185 92.00%

ORF Names:DKEY‐267I17.1‐001 EMBL CAM15799.1OrganismDanio rerio (Zebrafish) (Brachydanio rerio) ARP57880_P050 Q5EE44_XENLA Proprotein convertase 6F Xenopus laevis (African clawed frog) 1174 92.00%

ORF Names:DKEY‐267I17.1‐001 EMBL CAM15799.1OrganismDanio rerio Xenopus tropicalis (Western clawed frog) (Zebrafish) (Brachydanio rerio) ARP57880_P050 Q0P4Q8_XENTR Proprotein convertase subtilisin/kexin type 5 (Silurana tropicalis) 911 92.00% Msi1 ARP41112_T100 Q91920_XENLA Ribonucleoprotein Xenopus laevis (African clawed frog) 406 100.00% Msi1 ARP41112_T100 B7ZQK5_XENLA Ribonucleoprotein Xenopus laevis (African clawed frog) 406 100.00% Msi1 ARP41112_T100 B7ZQP4_XENLA Putative uncharacterized protein Xenopus laevis (African clawed frog) 348 92.00% Xenopus tropicalis (Western clawed frog) Msi1 ARP41112_T100 B0BM91_XENTR LOC100144993 protein (Silurana tropicalis) 383 92.00%

Heterogeneous nuclear ribonucleoprotein A3 Msi1 ARP41112_T100 RO32_XENLA homolog 2 (hnRNP A3(B)) Xenopus laevis (African clawed frog) 385 92.00%

Heterogeneous nuclear ribonucleoprotein A3 Msi1 ARP41112_T100 RO31_XENLA homolog 1 (hnRNP A3(A)) Xenopus laevis (African clawed frog) 373 92.00% LOC397764 protein (‐specific Msi1 ARP41112_T100 Q91808_XENLA RNA‐binding protein (nrp‐1B)) Xenopus laevis (African clawed frog) 340 92.00% Nervous system‐specific RNA‐binding protein Msi1 ARP41112_T100 Q91807_XENLA (nrp‐1A) Xenopus laevis (African clawed frog) 347 92.00% Msi1 ARP41112_T100 Q5U4T5_XENLA Msi1h protein Xenopus laevis (African clawed frog) 321 92.00% Xenopus tropicalis (Western clawed frog) Msi1 ARP41112_T100 Q5I081_XENTR Musashi homolog 1 (Silurana tropicalis) 340 92.00% Msi1 ARP41112_T100 Q7ZWV4_XENLA Hnrpa2b1 protein Xenopus laevis (African clawed frog) 346 85.00% Msi1 ARP41112_T100 Q3KPP1_XENLA MGC52881 protein Xenopus laevis (African clawed frog) 346 85.00% Heterogeneous nuclear ribonucleoprotein Xenopus tropicalis (Western clawed frog) Msi1 ARP41112_T100 Q28EZ2_XENTR A2/B1 (Silurana tropicalis) 327 85.00% Xenopus tropicalis (Western clawed frog) Msi1 ARP41112_T100 A9ULK4_XENTR Hnrnpa2b1 protein (Silurana tropicalis) 154 85.00% Xenopus tropicalis (Western clawed frog) Msi1 ARP41112_T100 A4IH31_XENTR Hnrpa2b1 protein (Silurana tropicalis) 349 85.00% Msi1 ARP41112_T100 RO22_XENLA Isoform Short Xenopus laevis (African clawed frog) 346 85.00%

Heterogeneous nuclear ribonucleoprotein A2 Msi1 ARP41112_T100 RO22_XENLA homolog 2 (hnRNP A2(B)) Xenopus laevis (African clawed frog) 358 85.00%

Heterogeneous nuclear ribonucleoprotein A2 Msi1 ARP41112_T100 RO21_XENLA homolog 1 (hnRNP A2(A)) Xenopus laevis (African clawed frog) 346 85.00% Msi1 ARP41112_T100 Q7ZX33_XENLA Hnrpa1 protein Xenopus laevis (African clawed frog) 399 85.00% Msi1 ARP41112_T100 Q6IP29_XENLA LOC397751 protein Xenopus laevis (African clawed frog) 365 85.00% Xenopus tropicalis (Western clawed frog) Msi1 ARP41112_T100 Q5XGF4_XENTR Heterogeneous nuclear ribonucleoprotein A1 (Silurana tropicalis) 343 85.00% Msi1 ARP41112_T100 ROA1_XENLA Isoform A1‐B Xenopus laevis (African clawed frog) 351 85.00%

Heterogeneous nuclear ribonucleoproteins A1 homolog (hnRNP A1) (Helix‐destabilizing protein) (Single‐strand‐binding protein) Msi1 ARP41112_T100 ROA1_XENLA (hnRNP core protein A1) Xenopus laevis (African clawed frog) 365 85.00% ORF Names:RRSL_01023 EMBL EAP71579.1OrganismRalstonia solanacearum UW551 ARP42254_T100 Q7ZX95_XENLA LOC398502 protein (Fragment) Xenopus laevis (African clawed frog) 497 100.00% ORF Names:RRSL_01023 EMBL EAP71579.1OrganismRalstonia solanacearum UW551 ARP42254_T100 Q6NRZ2_XENLA LOC398502 protein Xenopus laevis (African clawed frog) 491 100.00% ORF Names:RRSL_01023 EMBL EAP71579.1OrganismRalstonia Nicotinamide phosphoribosyltransferase (Pre Xenopus tropicalis (Western clawed frog) solanacearum UW551 ARP42254_T100 Q5M7L4_XENTR B cell colony enhancing factor 1) (Silurana tropicalis) 491 100.00% ORF Names:RRSL_01023 EMBL EAP71579.1OrganismRalstonia solanacearum UW551 ARP42254_T100 Q5FWL1_XENLA MGC85013 protein Xenopus laevis (African clawed frog) 491 100.00%

ORF Names:TRIADDRAFT_21768 EMBL EDV27572.1OrganismTrichoplax adhaerens (Trichoplax reptans) ARP40588_P050 Q5U4J9_XENLA LOC495482 protein (Fragment) Xenopus laevis (African clawed frog) 373 100.00%

ORF Names:TRIADDRAFT_21768 EMBL EDV27572.1OrganismTrichoplax adhaerens (Trichoplax reptans) ARP40588_P050 Q3B8L4_XENLA LOC495482 protein (Fragment) Xenopus laevis (African clawed frog) 388 100.00%

ORF Names:TRIADDRAFT_21768 EMBL EDV27572.1OrganismTrichoplax Xenopus tropicalis (Western clawed frog) adhaerens (Trichoplax reptans) ARP40588_P050 Q05AQ6_XENTR Putative uncharacterized protein MGC147622 (Silurana tropicalis) 391 100.00% Xenopus tropicalis (Western clawed frog) Osgin2 ARP55853_P050 Q4FZE1_XENTR Putative uncharacterized protein mgc108201 (Silurana tropicalis) 505 85.00% ORF Names:ACLA_035980 EMBL EAW09395.1OrganismAspergillus clavatus ARP34222_P050 Q6GN59_XENLA MGC83004 protein Xenopus laevis (African clawed frog) 998 92.00% ARP33695_P050 Q9IB60_XENLA Smad interaction protein 1 Xenopus laevis (African clawed frog) 1214 84.00% ARP33695_P050 Q9I8P1_XENLA Smad‐interacting protein 1 Xenopus laevis (African clawed frog) 1213 84.00% ARP33695_P050 Q5U4S2_XENLA Sip1 protein Xenopus laevis (African clawed frog) 1214 84.00% Xenopus tropicalis (Western clawed frog) gas7 ARP47759_T100 B1H3K4_XENTR LOC100145655 protein (Silurana tropicalis) 472 85.00% gas7 ARP47759_T100 A0JPG4_XENLA Gas7 protein Xenopus laevis (African clawed frog) 474 85.00% Xenopus tropicalis (Western clawed frog) ST8Sia IIa ARP46681_P050 Q0V9R7_XENTR Sialyltransferase 8B (Silurana tropicalis) 370 85.00% ST8Sia IIa ARP46681_P050 O93234_XENLA Alpha‐2,8‐polysialyltransferase Xenopus laevis (African clawed frog) 375 85.00% ARP48564_P050 Q52MA3_XENLA Putative uncharacterized protein Xenopus laevis (African clawed frog) 520 100.00%

ORF Names:v1g246114OrganismNematostel la vectensis (Starlet sea anemone) ARP33019_P050 Q6GN20_XENLA MGC83625 protein Xenopus laevis (African clawed frog) 474 85.00%

ORF Names:v1g246114OrganismNematostel Xenopus tropicalis (Western clawed frog) la vectensis (Starlet sea anemone) ARP33019_P050 B3DLW7_XENTR Sufu protein (Silurana tropicalis) 474 85.00% 26S protease regulatory subunit 7 (Proteasome (Prosome, macropain) 26S Xenopus tropicalis (Western clawed frog) psmc2 ARP34239_P050 Q6P7K3_XENTR subunit, ATPase 2) (Silurana tropicalis) 433 84.00% Xenopus tropicalis (Western clawed frog) psmc2 ARP34239_P050 Q68ER4_XENTR 26S protease regulatory subunit 7 (Silurana tropicalis) 433 84.00% psmc2 ARP34239_P050 A9ULV8_XENLA XMSS1 protein Xenopus laevis (African clawed frog) 433 84.00% 26S protease regulatory subunit 7 (26S proteasome AAA‐ATPase subunit RPT1) (Proteasome 26S subunit ATPase 2) (Protein psmc2 ARP34239_P050 PRS7_XENLA MSS1) (xMSS1) Xenopus laevis (African clawed frog) 433 84.00% psmc2 ARP34239_P050 Q7ZTR7_XENLA Psmc2 protein (Fragment) Xenopus laevis (African clawed frog) 444 76.00% LOC100036794 ARP53203_P050 A0JPH0_XENLA LOC100036794 protein Xenopus laevis (African clawed frog) 304 92.00% Ebf3 ARP31837_T100 B7ZRR5_XENLA Xebf‐3 protein Xenopus laevis (African clawed frog) 597 100.00% Xenopus tropicalis (Western clawed frog) Ebf3 ARP31837_T100 A9ULR8_XENTR LOC100135240 protein (Fragment) (Silurana tropicalis) 496 100.00% Transcription factor COE3 (xCOE3) (Olf‐1/EBF‐ Ebf3 ARP31837_T100 COE3_XENLA like 2) (OE‐2) (xEBF‐3) (xOE‐2) Xenopus laevis (African clawed frog) 598 100.00% ARP35089_P050 Q8AVI5_XENLA MGC53410 protein Xenopus laevis (African clawed frog) 331 81.00% Xenopus tropicalis (Western clawed frog) ARP35089_P050 Q5HZV4_XENTR Potassium channel, subfamily K, member 1 (Silurana tropicalis) 330 81.00% GF13249 ARP44220_P050 Q98SV5_XENLA Exostosin (Exostosin 1) Xenopus laevis (African clawed frog) 738 100.00% GF13249 ARP44220_P050 Q8QGX3_XENLA XEXT1 Xenopus laevis (African clawed frog) 735 100.00% Xenopus tropicalis (Western clawed frog) GF13249 ARP44220_P050 Q6DIQ4_XENTR Exostoses (Multiple) 1 (Silurana tropicalis) 738 100.00% GF13249 ARP44220_P050 Q6DE99_XENLA XEXT1 protein Xenopus laevis (African clawed frog) 735 100.00% GF13249 ARP44220_P050 Q52KD9_XENLA XEXT1 protein Xenopus laevis (African clawed frog) 738 100.00% RNA‐binding protein 5‐B (RNA‐binding motif rbm5‐a ARP38684_P050 RBM5B_XENLA protein 5‐B) Xenopus laevis (African clawed frog) 749 85.00% RNA‐binding protein 5 (RNA‐binding motif Xenopus tropicalis (Western clawed frog) rbm5‐a ARP38684_P050 RBM5_XENTR protein 5) (Silurana tropicalis) 838 78.00% RNA‐binding protein 5‐A (RNA‐binding motif rbm5‐a ARP38684_P050 RBM5A_XENLA protein 5‐A) Xenopus laevis (African clawed frog) 833 78.00% ARP33370_P050 Q7ZYJ6_XENLA MGC52909 protein Xenopus laevis (African clawed frog) 291 78.00% ARP33370_P050 Q641B3_XENLA MGC83328 protein Xenopus laevis (African clawed frog) 290 78.00% LSM1 homolog, U6 small nuclear RNA Xenopus tropicalis (Western clawed frog) lsm1 ARP40770_P050 Q5PPQ2_XENTR associated (S. cerevisiae) (Silurana tropicalis) 133 92.00% lsm1 ARP40770_P050 Q3KPZ8_XENLA MGC131170 protein Xenopus laevis (African clawed frog) 133 92.00% lsm1 ARP40770_P050 A5D8N1_XENLA LOC100049754 protein Xenopus laevis (African clawed frog) 133 92.00% nkiras1 ARP55370_P050 A0JMW9_XENLA Nkiras1 protein Xenopus laevis (African clawed frog) 192 92.00% ORF Names:CC1G_00924 EMBL EAU90540.2OrganismCoprinopsis cinerea (strain Okayama‐7 / 130 / FGSC 9003) (Inky cap fungus) (Hormographiella aspergillata) ARP51350_P050 Q6NTS8_XENLA MGC68763 protein Xenopus laevis (African clawed frog) 89 92.00% ORF Names:CC1G_00924 EMBL EAU90540.2OrganismCoprinopsis cinerea (strain Okayama‐7 / 130 / FGSC 9003) (Inky cap fungus) (Hormographiella aspergillata) ARP51350_P050 Q6GPR8_XENLA Dynein light chain dlc8a (MGC82658 protein) Xenopus laevis (African clawed frog) 89 92.00% ORF Names:CC1G_00924 EMBL EAU90540.2OrganismCoprinopsis cinerea (strain Okayama‐7 / 130 / FGSC 9003) (Inky cap fungus) Dynein light chain 2 (Dynein, light chain, LC8‐ Xenopus tropicalis (Western clawed frog) (Hormographiella aspergillata) ARP51350_P050 Q6DEU5_XENTR type 1) (Silurana tropicalis) 89 92.00% ORF Names:CC1G_00924 EMBL EAU90540.2OrganismCoprinopsis cinerea (strain Okayama‐7 / 130 / FGSC 9003) (Inky cap fungus) (Hormographiella aspergillata) ARP51350_P050 Q5M781_XENLA Dynein light chain dlc8b (Dynll2 protein) Xenopus laevis (African clawed frog) 89 92.00% ORF Names:CC1G_00924 EMBL EAU90540.2OrganismCoprinopsis cinerea (strain Okayama‐7 / 130 / FGSC 9003) (Inky cap fungus) Xenopus tropicalis (Western clawed frog) (Hormographiella aspergillata) ARP51350_P050 B0BM87_XENTR Dynll2 protein (Silurana tropicalis) 89 92.00% IRF5 ARP31994_P050 Q63ZP8_XENLA LOC494760 protein Xenopus laevis (African clawed frog) 517 92.00% ORF Names:ACLA_049960 EMBL Ribose‐phosphate pyrophosphokinase 2 (EC EAW10524.1OrganismAspergillus 2.7.6.1) (Phosphoribosyl pyrophosphate Xenopus tropicalis (Western clawed frog) clavatus ARP41510_T100 PRPS2_XENTR synthase II) (PRS‐II) (Silurana tropicalis) 318 100.00% ORF Names:ACLA_049960 EMBL Ribose‐phosphate pyrophosphokinase 2 (EC EAW10524.1OrganismAspergillus 2.7.6.1) (Phosphoribosyl pyrophosphate clavatus ARP41510_T100 PRPS2_XENLA synthase II) (PRS‐II) Xenopus laevis (African clawed frog) 318 100.00% ORF Names:ACLA_049960 EMBL EAW10524.1OrganismAspergillus clavatus ARP41510_T100 Q7ZXR6_XENLA Prps1 protein (Fragment) Xenopus laevis (African clawed frog) 326 92.00% ORF Names:ACLA_049960 EMBL EAW10524.1OrganismAspergillus Similar to phosphoribosyl pyrophosphate Xenopus tropicalis (Western clawed frog) clavatus ARP41510_T100 Q6P830_XENTR synthetase 1 (Silurana tropicalis) 318 92.00% ORF Names:ACLA_049960 EMBL EAW10524.1OrganismAspergillus clavatus ARP41510_T100 Q6AZI9_XENLA Prps1 protein Xenopus laevis (African clawed frog) 318 92.00% RNA‐binding protein 42 (RNA‐binding motif Xenopus tropicalis (Western clawed frog) rbm42 ARP41009_P050 RBM42_XENTR protein 42) (Silurana tropicalis) 392 85.00% RNA‐binding protein 42 (RNA‐binding motif rbm42 ARP41009_P050 RBM42_XENLA protein 42) Xenopus laevis (African clawed frog) 392 85.00% rbm42 ARP41009_P050 A1L2K5_XENLA LOC100036875 protein Xenopus laevis (African clawed frog) 385 78.00% Xenopus tropicalis (Western clawed frog) ARP35469_P050 A4IIL3_XENTR Kcng1 protein (Silurana tropicalis) 508 92.00% ORF Names:v1g95684OrganismNematostell Novel zinc finger protein (Putative Xenopus tropicalis (Western clawed frog) a vectensis (Starlet sea anemone) ARP39039_P050 Q28EA2_XENTR uncharacterized protein LOC548732) (Silurana tropicalis) 336 83.00%

ORF Names:v1g95684OrganismNematostell Xenopus tropicalis (Western clawed frog) a vectensis (Starlet sea anemone) ARP39039_P050 B0JZ29_XENTR LOC548732 protein (Silurana tropicalis) 336 83.00% PIPNB ARP54894_P050 Q6DD01_XENLA Pitpnb‐prov protein Xenopus laevis (African clawed frog) 271 92.00% Xenopus tropicalis (Western clawed frog) PIPNB ARP54894_P050 Q05B20_XENTR Putative uncharacterized protein MGC146613 (Silurana tropicalis) 272 85.00% PIPNB ARP54894_P050 Q6INB2_XENLA MGC84500 protein Xenopus laevis (African clawed frog) 272 85.00% TFAP2A ARP33432_T100 Q66J14_XENLA MGC83414 protein Xenopus laevis (African clawed frog) 440 100.00%

Transcription factor AP‐2 beta (Activating Xenopus tropicalis (Western clawed frog) TFAP2A ARP33432_T100 Q28C75_XENTR enhancer binding protein 2 beta) (Silurana tropicalis) 441 100.00% TFAP2A ARP33432_T100 Q6PB21_XENLA MGC68493 protein Xenopus laevis (African clawed frog) 399 92.00% TFAP2A ARP33432_T100 Q6NTJ1_XENLA MGC68493 protein Xenopus laevis (African clawed frog) 442 92.00%

Transcription factor AP‐2 gamma (Activating Xenopus tropicalis (Western clawed frog) TFAP2A ARP33432_T100 Q5XGF5_XENTR enhancer binding protein 2 gamma) (Silurana tropicalis) 442 92.00%

Transcription factor AP‐2 gamma (Activating Xenopus tropicalis (Western clawed frog) TFAP2A ARP33432_T100 Q28F74_XENTR enhancer binding protein 2 gamma) (Silurana tropicalis) 444 92.00% Xenopus tropicalis (Western clawed frog) TFAP2A ARP33432_T100 Q9PUL8_XENTR Transcription factor AP‐2 (Fragment) (Silurana tropicalis) 430 78.00% TFAP2A ARP33432_T100 Q91867_XENLA Transcription factor Xenopus laevis (African clawed frog) 425 78.00% TFAP2A ARP33432_T100 Q6NTV4_XENLA Tfap2a‐a protein Xenopus laevis (African clawed frog) 407 78.00% TFAP2A ARP33432_T100 Q63ZP3_XENLA Tcfap2a protein Xenopus laevis (African clawed frog) 433 78.00%

Transcription factor AP‐2 alpha (Activating Xenopus tropicalis (Western clawed frog) TFAP2A ARP33432_T100 Q28EF8_XENTR enhancer binding protein 2 alpha) (Silurana tropicalis) 430 78.00%

Transcription factor AP‐2 alpha (Activating Xenopus tropicalis (Western clawed frog) TFAP2A ARP33432_T100 Q28EF6_XENTR enhancer binding protein 2 alpha) (Silurana tropicalis) 436 78.00% Xenopus tropicalis (Western clawed frog) TFAP2A ARP33432_T100 A4IHV0_XENTR Tfap2a protein (Silurana tropicalis) 428 78.00% Xenopus tropicalis (Western clawed frog) TFAP2A ARP33432_T100 B3DL96_XENTR Tfap2e protein (Silurana tropicalis) 434 78.00% Transcription factor AP‐2‐epsilon (AP‐2‐ TFAP2A ARP33432_T100 AP2E_XENLA epsilon) Xenopus laevis (African clawed frog) 434 78.00% ARP54713_P050 Q6NRL7_XENLA MGC83716 protein Xenopus laevis (African clawed frog) 447 78.00% ARP54713_P050 Q6NUB8_XENLA MGC81078 protein Xenopus laevis (African clawed frog) 447 90.00% RER1 ARP46815_P050 Q6DDM2_XENLA MGC83321 protein Xenopus laevis (African clawed frog) 198 92.00% Xenopus tropicalis (Western clawed frog) RER1 ARP46815_P050 Q5I089_XENTR Retention in endoplasmic reticulum protein 1 (Silurana tropicalis) 198 92.00%

ORF Names:IscW_ISCW023694 EMBL EEC19673.1OrganismIxodes scapularis (Black‐legged tick) (Deer tick) ARP51835_P050 Q52KD3_XENLA MGC85029 protein Xenopus laevis (African clawed frog) 713 100.00%

ORF Protein phosphatase 2, regulatory subunit B Names:AGAP009341OrganismAnophel (B56), delta isoform (Protein phosphatase 2, Xenopus tropicalis (Western clawed frog) es gambiae (African malaria mosquito) ARP57771_P050 Q6P3P7_XENTR regulatory subunit B, gamma isoform) (Silurana tropicalis) 577 100.00%

ORF Names:AGAP009341OrganismAnophel es gambiae (African malaria mosquito) ARP57771_P050 Q66J79_XENLA MGC81679 protein Xenopus laevis (African clawed frog) 506 100.00%

ORF Names:AGAP009341OrganismAnophel Xenopus tropicalis (Western clawed frog) es gambiae (African malaria mosquito) ARP57771_P050 Q6DIR9_XENTR PPP2R5E protein (Fragment) (Silurana tropicalis) 443 100.00%

ORF Names:AGAP009341OrganismAnophel es gambiae (African malaria mosquito) ARP57771_P050 Q6DFL3_XENLA Ppp2r5e‐prov protein Xenopus laevis (African clawed frog) 476 100.00%

ORF Names:AGAP009341OrganismAnophel Xenopus tropicalis (Western clawed frog) es gambiae (African malaria mosquito) ARP57771_P050 Q0IIU9_XENTR PPP2R5E protein (Silurana tropicalis) 476 100.00%

ORF Names:AGAP009341OrganismAnophel es gambiae (African malaria mosquito) ARP57771_P050 A9YWT2_XENLA Phosphatase regulatory subunit B56alpha Xenopus laevis (African clawed frog) 476 100.00%

ORF Names:AGAP009341OrganismAnophel es gambiae (African malaria mosquito) ARP57771_P050 Q9DF48_XENLA Protein phosphatase‐2A B'epsilon subunit Xenopus laevis (African clawed frog) 467 92.00%

ORF Names:AGAP009341OrganismAnophel Protein phosphatase 2, regulatory subunit B Xenopus tropicalis (Western clawed frog) es gambiae (African malaria mosquito) ARP57771_P050 Q6P3N1_XENTR (B56), epsilon isoform (Silurana tropicalis) 462 92.00%

ORF Names:AGAP009341OrganismAnophel es gambiae (African malaria mosquito) ARP57771_P050 Q5XH34_XENLA LOC495076 protein Xenopus laevis (African clawed frog) 467 92.00% ORF Names:AGAP009341OrganismAnophel Xenopus tropicalis (Western clawed frog) es gambiae (African malaria mosquito) ARP57771_P050 A4IIE4_XENTR Ppp2r5b protein (Silurana tropicalis) 491 84.00% Cbx3 protein (Heterochromatin protein 1 CBX3 ARP34721_T100 Q802A8_XENLA gamma) Xenopus laevis (African clawed frog) 174 85.00% Xenopus tropicalis (Western clawed frog) CBX3 ARP34721_T100 B1H306_XENTR Cbx3 protein (Silurana tropicalis) 174 85.00% CBX3 ARP34721_T100 Q7ZWZ6_XENLA Cbx3‐prov protein Xenopus laevis (African clawed frog) 174 78.00% Heterochromatin protein 1 gamma CBX3 ARP34721_T100 O42156_XENLA (Fragment) Xenopus laevis (African clawed frog) 171 78.00% ARP38154_P050 Q6DE53_XENLA Icsbp1‐prov protein Xenopus laevis (African clawed frog) 411 80.00% ARP38154_P050 Q6DD26_XENLA Putative uncharacterized protein Xenopus laevis (African clawed frog) 460 90.00% ATP2B2 ARP44394_P050 B3VIA2_XENLA Plasma membrane calcium ATPase 1b Xenopus laevis (African clawed frog) 1214 85.00% ATP2B2 ARP44394_P050 Q6DCT8_XENLA Atp2b3‐prov protein Xenopus laevis (African clawed frog) 1208 85.00% Xenopus tropicalis (Western clawed frog) ATP2B2 ARP44394_P050 B4F6S6_XENTR LOC100125191 protein (Silurana tropicalis) 1157 78.00% Xenopus tropicalis (Western clawed frog) AVARP09037_P050 B1WB71_XENTR Srebf2 protein (Silurana tropicalis) 1087 80.00% regulatory element‐binding protein 2 (SREBP‐2) (Sterol regulatory element‐binding transcription factor 2) [Cleaved into: Processed sterol regulatory element‐binding AVARP09037_P050 SRBP2_XENLA protein 2] Xenopus laevis (African clawed frog) 1088 80.00% Xenopus tropicalis (Western clawed frog) GEM ARP42226_T100 Q0V9B4_XENTR Gem protein (Silurana tropicalis) 299 100.00% STAT1 ARP38933_P050 Q8JGN0_XENLA Stat1 Xenopus laevis (African clawed frog) 751 92.00% Signal transducer and activator of Xenopus tropicalis (Western clawed frog) STAT1 ARP38933_P050 Q08D02_XENTR transcription 1, 91kDa (Silurana tropicalis) 648 92.00% STAT1 ARP38933_P050 A3KMT9_XENLA Putative uncharacterized protein Xenopus laevis (African clawed frog) 432 92.00% Xenopus tropicalis (Western clawed frog) tars ARP46359_T100 Q6NVQ6_XENTR Threonyl‐tRNA synthetase‐like 2 (Silurana tropicalis) 721 85.00% tars ARP46359_T100 Q642N9_XENLA MGC86352 protein Xenopus laevis (African clawed frog) 721 85.00% Probable threonyl‐tRNA synthetase 2, cytoplasmic (EC 6.1.1.3) (Threonine‐‐tRNA ligase) (ThrRS) (Threonyl‐tRNA synthetase‐like Xenopus tropicalis (Western clawed frog) tars ARP46359_T100 SYTC2_XENTR protein 2) (Silurana tropicalis) 814 84.00% Xenopus tropicalis (Western clawed frog) rpS24 ARP40304_P050 A4IHK4_XENTR Putative uncharacterized protein LOC549379 (Silurana tropicalis) 132 100.00% rpS24 ARP40304_P050 RS24_XENLA 40S ribosomal protein S24 (S19) Xenopus laevis (African clawed frog) 132 100.00% DKEYP‐104H9.2 ARP42420_P050 Q6NRV9_XENLA MGC81251 protein Xenopus laevis (African clawed frog) 756 100.00% Xenopus tropicalis (Western clawed frog) DKEYP‐104H9.2 ARP42420_P050 Q28CS2_XENTR Mitofusin 2 (Silurana tropicalis) 756 92.00% Xenopus tropicalis (Western clawed frog) DKEYP‐104H9.2 ARP42420_P050 B7ZTV0_XENTR Mitofusin 2 (Silurana tropicalis) 756 92.00% pstA ARP39390_T100 Q6NUC3_XENLA MGC81069 protein Xenopus laevis (African clawed frog) 573 91.00% Xenopus tropicalis (Western clawed frog) pstA ARP39390_T100 Q28H22_XENTR Methyltransferase like 3 (Silurana tropicalis) 573 91.00% Xenopus tropicalis (Western clawed frog) znf687 ARP39447_P050 A0JP81_XENTR Znf687 protein (Silurana tropicalis) 1271 84.00% Padi4 ARP52328_P050 Q7ZWR3_XENLA Padi2‐prov protein Xenopus laevis (African clawed frog) 660 84.00% Xenopus tropicalis (Western clawed frog) Padi4 ARP52328_P050 A4IHA9_XENTR LOC100125112 protein (Silurana tropicalis) 658 84.00% Xenopus tropicalis (Western clawed frog) SUV420H1 ARP34744_P050 Q07G74_XENTR Novel protein similar to suv420h1 (Fragment) (Silurana tropicalis) 645 100.00% Histone‐lysine N‐methyltransferase SUV420H1‐ B (EC 2.1.1.43) (Suppressor of variegation 4‐ 20 homolog 1‐B) (Su(var)4‐20 homolog 1‐B) SUV420H1 ARP34744_P050 S421B_XENLA (Suv4‐20h1‐B) Xenopus laevis (African clawed frog) 785 100.00% Histone‐lysine N‐methyltransferase SUV420H1‐ A (EC 2.1.1.43) (Suppressor of variegation 4‐ 20 homolog 1‐A) (Su(var)4‐20 homolog 1‐A) SUV420H1 ARP34744_P050 S421A_XENLA (Suv4‐20h1‐A) Xenopus laevis (African clawed frog) 855 100.00% ORF Names:ACLA_082360 EMBL EAW06545.1OrganismAspergillus clavatus ARP56467_P050 A9JS79_XENLA LOC100127332 protein (Fragment) Xenopus laevis (African clawed frog) 253 100.00% ORF Names:ACLA_082360 EMBL EAW06545.1OrganismAspergillus clavatus ARP56467_P050 Q9IBC2_XENLA Proteasome subunit LMP7 (Fragment) Xenopus laevis (African clawed frog) 87 83.00% ORF Names:ACLA_082360 EMBL EAW06545.1OrganismAspergillus clavatus ARP56467_P050 Q9IBB8_9PIPI Proteasome subunit LMP7B (Fragment) Xenopus laevis/gilli 87 83.00% ORF Names:ACLA_082360 EMBL EAW06545.1OrganismAspergillus clavatus ARP56467_P050 Q9IBB3_9PIPI Proteasome subunit LMP7B (Fragment) Xenopus vestitus (Kivu clawed frog) 87 83.00% ORF Names:ACLA_082360 EMBL EAW06545.1OrganismAspergillus clavatus ARP56467_P050 Q9I875_9PIPI Proteasome subunit LMP7B (Fragment) Xenopus ruwenzoriensis (Uganda clawed frog) 87 83.00% ORF Names:ACLA_082360 EMBL EAW06545.1OrganismAspergillus Low molecular mass protein‐7 (LMP‐7) clavatus ARP56467_P050 Q91788_XENLA homolog Xenopus laevis (African clawed frog) 271 83.00% ORF Names:ACLA_082360 EMBL EAW06545.1OrganismAspergillus clavatus ARP56467_P050 Q6PCG4_XENLA MGC69086 protein Xenopus laevis (African clawed frog) 271 83.00% ORF Names:TVAG_302260 EMBL EAY08139.1, TVAG_302270 EMBL EAY08140.1OrganismTrichomonas Eif4h protein (Williams‐Beuren syndrome Xenopus tropicalis (Western clawed frog) vaginalis ARP40978_T100 Q28E99_XENTR chromosome region 1 homolog) (Silurana tropicalis) 252 81.00% ORF Names:TVAG_302260 EMBL EAY08139.1, TVAG_302270 EMBL EAY08140.1OrganismTrichomonas vaginalis ARP40978_T100 Q6AZF3_XENLA Wbscr1‐prov protein Xenopus laevis (African clawed frog) 250 81.00%

Succinate dehydrogenase [ubiquinone] iron‐ sulfur subunit, mitochondrial (EC 1.3.5.1) (Iron‐ sucA ARP47981_P050 DHSB_XENLA sulfur subunit of complex II) (Ip) Xenopus laevis (African clawed frog) 282 92.00%

Succinate dehydrogenase [ubiquinone] iron‐ sulfur subunit, mitochondrial (EC 1.3.5.1) (Iron‐Xenopus tropicalis (Western clawed frog) sucA ARP47981_P050 DHSB_XENTR sulfur subunit of complex II) (Ip) (Silurana tropicalis) 284 92.00% ARP48203_T100 Q8AVT0_XENLA MGC53543 protein Xenopus laevis (African clawed frog) 434 92.00% ARP48203_T100 Q7ZXA3_XENLA Eno3‐prov protein Xenopus laevis (African clawed frog) 434 92.00% ARP48203_T100 Q7SZ25_XENLA Eno1‐prov protein Xenopus laevis (African clawed frog) 434 92.00% Xenopus tropicalis (Western clawed frog) ARP48203_T100 Q6P8E1_XENTR Enolase 1, (Alpha) (Silurana tropicalis) 434 92.00% Mgc108129 protein (Putative uncharacterized Xenopus tropicalis (Western clawed frog) ARP48203_T100 Q4VA70_XENTR protein mgc108129) (Silurana tropicalis) 434 92.00% Xenopus tropicalis (Western clawed frog) ARP48203_T100 B0BMH7_XENTR Eno1 protein (Silurana tropicalis) 434 92.00% ARP48203_T100 A1L3K7_XENLA LOC100037034 protein Xenopus laevis (African clawed frog) 434 92.00% Alpha‐enolase (EC 4.2.1.11) (2‐phospho‐D‐ glycerate hydro‐lyase) (2‐phosphoglycerate ARP48203_T100 ENOA_XENLA dehydratase) Xenopus laevis (African clawed frog) 434 92.00% ARP40269_T100 Q6PAA8_XENLA MGC68512 protein Xenopus laevis (African clawed frog) 200 100.00% Xenopus tropicalis (Western clawed frog) ARP40269_T100 A9UME4_XENTR LOC100135328 protein (Silurana tropicalis) 199 92.00% ARP40269_T100 Q66IX3_XENLA MGC84222 protein Xenopus laevis (African clawed frog) 197 78.00% RNA‐binding protein with multiple splicing (RBP‐MS) (Heart and RRM expressed ARP40269_T100 RBPMS_XENLA sequence) (Hermes) Xenopus laevis (African clawed frog) 196 78.00% Sh2d3c ARP53208_P050 Q8AVM4_XENLA Sh2d3c‐prov protein Xenopus laevis (African clawed frog) 676 100.00% Xenopus tropicalis (Western clawed frog) esr2 ARP32258_P050 Q6W5G8_XENTR beta (Fragment) (Silurana tropicalis) 372 78.00% Xenopus tropicalis (Western clawed frog) esr2 ARP32258_P050 B7ZUD8_XENTR Estrogen receptor 2 (ER beta) (Silurana tropicalis) 548 78.00% esr2 ARP32258_P050 B2NIY5_XENLA Gonad estrogen receptor beta2 Xenopus laevis (African clawed frog) 476 78.00% esr2 ARP32258_P050 B2NIY4_XENLA Gonad estrogen receptor beta1 Xenopus laevis (African clawed frog) 548 78.00% ARP57975_P050 Q6GPM9_XENLA LOC443625 protein (Fragment) Xenopus laevis (African clawed frog) 514 78.00% Xenopus tropicalis (Western clawed frog) ARP57975_P050 B1H2P4_XENTR Ikzf2 protein (Silurana tropicalis) 523 78.00%

Bifunctional arginine demethylase and lysyl‐ hydroxylase JMJD6‐B (EC 1.14.11.‐) (Histone arginine demethylase JMJD6‐B) (JmjC domain‐ containing protein 6‐B) (Jumonji domain‐ containing protein 6‐B) (Lysyl‐hydroxylase JMJD6‐B) (Peptide‐lysine 5‐dioxygenase JMJD6‐B) (Phosphatidylserine receptor‐B) ARP39181_T100 JMD6B_XENLA (Protein PTDSR‐B) Xenopus laevis (African clawed frog) 403 92.00%

Bifunctional arginine demethylase and lysyl‐ hydroxylase JMJD6‐A (EC 1.14.11.‐) (Histone arginine demethylase JMJD6‐A) (JmjC domain‐ containing protein 6‐A) (Jumonji domain‐ containing protein 6‐A) (Lysyl‐hydroxylase JMJD6‐A) (Peptide‐lysine 5‐dioxygenase JMJD6‐A) (Phosphatidylserine receptor‐A) ARP39181_T100 JMD6A_XENLA (Protein PTDSR‐A) Xenopus laevis (African clawed frog) 403 85.00% Rac3 ARP55742_P050 Q9W760_XENLA Small Rho‐like GTPase RhoA Xenopus laevis (African clawed frog) 193 100.00% Rac3 ARP55742_P050 Q9PW31_XENLA RAC1 protein (Rac GTPase) Xenopus laevis (African clawed frog) 192 100.00% Cdc42 protein (Rho GTPase Cdc42) (Rho Rac3 ARP55742_P050 Q9DDV6_XENLA family small GTP binding protein cdc42) Xenopus laevis (African clawed frog) 191 100.00% Rac3 ARP55742_P050 Q8JHE2_XENLA Small GTPase RhoA Xenopus laevis (African clawed frog) 193 100.00% Rac3 ARP55742_P050 Q7ZXM0_XENLA Arha2‐prov protein Xenopus laevis (African clawed frog) 193 100.00% Rac3 ARP55742_P050 Q7ZWY1_XENLA MGC52893 protein Xenopus laevis (African clawed frog) 193 100.00% Rac3 ARP55742_P050 Q7SZA9_XENLA MGC64296 protein Xenopus laevis (African clawed frog) 193 100.00% Xenopus tropicalis (Western clawed frog) Rac3 ARP55742_P050 Q6NVL3_XENTR Ras homolog gene family, member B (Silurana tropicalis) 196 100.00% Rac3 ARP55742_P050 Q6GP43_XENLA MGC80698 protein Xenopus laevis (African clawed frog) 192 100.00%

Ras‐related C3 botulinum toxin substrate 1 Xenopus tropicalis (Western clawed frog) Rac3 ARP55742_P050 Q6GL60_XENTR (Rho family, small GTP binding protein Rac1) (Silurana tropicalis) 192 100.00% Rac3 ARP55742_P050 Q6DCB8_XENLA Rhof‐prov protein Xenopus laevis (African clawed frog) 218 100.00% Cell division cycle 42 (GTP binding protein, Xenopus tropicalis (Western clawed frog) Rac3 ARP55742_P050 Q66JI0_XENTR 25kDa) (Silurana tropicalis) 191 100.00% Rac3 ARP55742_P050 Q5U264_XENLA LOC495677 protein Xenopus laevis (African clawed frog) 218 100.00% Novel protein similar to ras‐related C3 botulinum toxin substrate 1 (Rho family, small GTP binding protein Rac1) (Ras‐related C3 botulinum toxin substrate 2 (Rho family, small Xenopus tropicalis (Western clawed frog) Rac3 ARP55742_P050 Q5M8J2_XENTR GTP binding protein Rac2)) (Silurana tropicalis) 192 100.00% Rac3 ARP55742_P050 Q58E25_XENLA MGC114731 protein Xenopus laevis (African clawed frog) 192 100.00% Rac3 ARP55742_P050 Q2TAR5_XENLA MGC131029 protein Xenopus laevis (African clawed frog) 196 100.00% Novel Rho protein (Ras homolog gene family, Xenopus tropicalis (Western clawed frog) Rac3 ARP55742_P050 Q28IJ0_XENTR member A, gene 2) (Silurana tropicalis) 193 100.00% Novel Rho protein (Putative uncharacterized Xenopus tropicalis (Western clawed frog) Rac3 ARP55742_P050 Q28HZ4_XENTR protein LOC549323) (Silurana tropicalis) 193 100.00% Ras homolog gene family, member F (In Xenopus tropicalis (Western clawed frog) Rac3 ARP55742_P050 Q28GP9_XENTR filopodia) (Silurana tropicalis) 218 100.00% Xenopus tropicalis (Western clawed frog) Rac3 ARP55742_P050 Q28GJ8_XENTR Ras homolog gene family, member A (Silurana tropicalis) 193 100.00% Cell division cycle 42 (GTP binding protein, Xenopus tropicalis (Western clawed frog) Rac3 ARP55742_P050 Q28BZ0_XENTR 25kDa) (Silurana tropicalis) 191 100.00% Xenopus tropicalis (Western clawed frog) Rac3 ARP55742_P050 B2GU04_XENTR LOC100158472 protein (Silurana tropicalis) 205 100.00% Xenopus tropicalis (Western clawed frog) Rac3 ARP55742_P050 A4IHY4_XENTR Rac3 protein (Silurana tropicalis) 192 100.00% Etv1 ARP38468_P050 Q9W696_XENLA Ets transcription factor (XER81 protein) Xenopus laevis (African clawed frog) 477 100.00% Xenopus tropicalis (Western clawed frog) Etv1 ARP38468_P050 Q6P4Z1_XENTR Ets variant 1 (Silurana tropicalis) 495 100.00% Etv1 ARP38468_P050 Q6GQB8_XENLA LOC398358 protein Xenopus laevis (African clawed frog) 477 100.00% Ets‐related transcription factor XER81 Etv1 ARP38468_P050 O93322_XENLA (Fragment) Xenopus laevis (African clawed frog) 477 100.00% Cytoplasmic element binding Cpeb3 ARP41187_T100 D8V196_XENLA protein 4 Xenopus laevis (African clawed frog) 704 100.00% Cytoplasmic polyadenylation element‐binding protein 3 (CPE‐BP3) (CPE‐binding protein 3) Xenopus tropicalis (Western clawed frog) Cpeb3 ARP41187_T100 CPEB3_XENTR (CPEB‐3) (Silurana tropicalis) 632 100.00% rnhB ARP40647_T100 Q6GNJ4_XENLA LOC443655 protein (Fragment) Xenopus laevis (African clawed frog) 305 92.00% rnhB ARP40647_T100 Q4FZN2_XENLA Putative uncharacterized protein Xenopus laevis (African clawed frog) 302 92.00% Xenopus tropicalis (Western clawed frog) rnhB ARP40647_T100 Q6P7L6_XENTR Ribonuclease H2, large subunit (Silurana tropicalis) 301 85.00% Xenopus tropicalis (Western clawed frog) rnhB ARP40647_T100 Q28IJ5_XENTR Ribonuclease H2, large subunit (Silurana tropicalis) 301 85.00% ARP56479_P050 Q6GNC1_XENLA MGC82894 protein Xenopus laevis (African clawed frog) 498 85.00% ORF Names:CH1073‐297E15.1‐001 EMBL CAQ14154.1OrganismDanio rerio (Zebrafish) (Brachydanio rerio) ARP51839_P050 Q6DF77_XENLA Gphn protein Xenopus laevis (African clawed frog) 857 100.00%

ORF Names:CH1073‐297E15.1‐001 EMBL CAQ14154.1OrganismDanio rerio (Zebrafish) (Brachydanio rerio) ARP51839_P050 Q6GQZ6_XENLA MGC83148 protein Xenopus laevis (African clawed frog) 860 92.00% ORF Names:AC3_A0269 EMBL EDT14255.1OrganismClostridium Xenopus tropicalis (Western clawed frog) perfringens E str. JGS1987 ARP40311_P050 Q6NVU1_XENTR SERPINE1 mRNA binding protein 1 (Silurana tropicalis) 406 85.00% ORF Names:AC3_A0269 EMBL EDT14255.1OrganismClostridium Xenopus tropicalis (Western clawed frog) perfringens E str. JGS1987 ARP40311_P050 Q28FI2_XENTR PAI‐1 mRNA‐binding protein (Silurana tropicalis) 401 85.00% ORF Names:AC3_A0269 EMBL EDT14255.1OrganismClostridium perfringens E str. JGS1987 ARP40311_P050 Q7ZWZ2_XENLA Rda288‐prov protein Xenopus laevis (African clawed frog) 392 85.00%

ORF Names:v1g194326OrganismNematostel la vectensis (Starlet sea anemone) ARP35124_P050 Q52KY1_XENLA Vdac2 protein Xenopus laevis (African clawed frog) 283 78.00%

ORF Names:v1g194326OrganismNematostel Xenopus tropicalis (Western clawed frog) la vectensis (Starlet sea anemone) ARP35124_P050 Q07G51_XENTR Voltage‐dependent anion channel 2 (Silurana tropicalis) 283 78.00%

ORF Voltage‐dependent anion‐selective channel Names:v1g194326OrganismNematostel protein 2 (VDAC‐2) (Outer mitochondrial la vectensis (Starlet sea anemone) ARP35124_P050 VDAC2_XENLA ) Xenopus laevis (African clawed frog) 282 78.00%

ORF Names:v1g194326OrganismNematostel la vectensis (Starlet sea anemone) ARP35124_P050 Q6GR11_XENLA MGC81430 protein Xenopus laevis (African clawed frog) 283 78.00%

ORF Names:v1g194326OrganismNematostel Xenopus tropicalis (Western clawed frog) la vectensis (Starlet sea anemone) ARP35124_P050 Q5M8U0_XENTR Voltage‐dependent anion channel 3 (Silurana tropicalis) 283 78.00% ORF Names:PANDA_001706 EMBL EFB20576.1OrganismAiluropoda melanoleuca (Giant panda) ARP40829_P050 Q6PF68_XENLA MGC68842 protein Xenopus laevis (African clawed frog) 125 100.00% ORF Names:PANDA_001706 EMBL EFB20576.1OrganismAiluropoda Putative uncharacterized protein LOC550003 Xenopus tropicalis (Western clawed frog) melanoleuca (Giant panda) ARP40829_P050 Q28J16_XENTR (Splicing factor 3B, 14 kDa subunit (Sf3b14)) (Silurana tropicalis) 125 100.00% Xenopus tropicalis (Western clawed frog) Celsr2 ARP49367_P050 Q0V9M2_XENTR Putative uncharacterized protein MGC146652 (Silurana tropicalis) 911 78.00%

Cold‐inducible RNA‐binding protein B (Cold‐ inducible RNA‐binding protein 2) (xCIRP2) ARP40349_P050 CIRBB_XENLA (Glycine‐rich RNA‐binding protein CIRP‐B) Xenopus laevis (African clawed frog) 166 92.00% Cold‐inducible RNA‐binding protein (Glycine‐ Xenopus tropicalis (Western clawed frog) ARP40349_P050 CIRBP_XENTR rich RNA‐binding protein CIRP) (Silurana tropicalis) 166 78.00% MORF4L1 ARP32831_P050 Q66J61_XENLA MGC81811 protein Xenopus laevis (African clawed frog) 321 92.00% Xenopus tropicalis (Western clawed frog) MORF4L1 ARP32831_P050 Q5U4Y3_XENTR Mortality factor 4 like 2 (Silurana tropicalis) 323 92.00% Xenopus tropicalis (Western clawed frog) MORF4L1 ARP32831_P050 Q28EZ5_XENTR Mortality factor 4 like 1 (Silurana tropicalis) 323 92.00% ARP48046_T100 Q6PGS3_XENLA Ywhaz protein Xenopus laevis (African clawed frog) 245 92.00% Xenopus tropicalis (Western clawed frog) ARP48046_T100 1433Z_XENTR 14‐3‐3 protein zeta (Silurana tropicalis) 245 92.00% ARP48046_T100 1433Z_XENLA 14‐3‐3 protein zeta Xenopus laevis (African clawed frog) 245 92.00% ARP48046_T100 Q8AVW5_XENLA Ywhaz‐prov protein Xenopus laevis (African clawed frog) 245 85.00% Signal transducer and activator of ARP38253_P050 STA32_XENLA transcription 3.2 (Protein Stat3‐A) Xenopus laevis (African clawed frog) 766 100.00% Signal transducer and activator of ARP38253_P050 STA31_XENLA transcription 3.1 (Protein Stat3) (Xstat3) Xenopus laevis (African clawed frog) 769 100.00% AVARP02062_P050 1433T_XENLA 14‐3‐3 protein theta Xenopus laevis (African clawed frog) 245 100.00% ORF Names:PANDA_004152 EMBL EFB14698.1OrganismAiluropoda melanoleuca (Giant panda) ARP50771_P050 Q6DDY5_XENLA MGC81469 protein Xenopus laevis (African clawed frog) 490 84.00% ARP55943_P050 Q4KLR1_XENLA MGC115614 protein Xenopus laevis (African clawed frog) 516 92.00% Xenopus tropicalis (Western clawed frog) ARP55943_P050 B5DE92_XENTR Putative uncharacterized protein (Silurana tropicalis) 516 92.00% ORF Names:GSPATT00038381001 EMBL CAK70279.1OrganismParamecium tetraurelia ARP40458_P050 Q7ZXH4_XENLA Srp54 protein Xenopus laevis (African clawed frog) 504 100.00% ORF Names:GSPATT00038381001 EMBL CAK70279.1OrganismParamecium Xenopus tropicalis (Western clawed frog) tetraurelia ARP40458_P050 Q6P862_XENTR Signal recognition particle 54 (Silurana tropicalis) 504 100.00%

ORF Names:GSTENG00029614001 EMBL CAG08600.1OrganismTetraodon Xenopus tropicalis (Western clawed frog) nigroviridis (Green puffer) ARP39397_P050 B1H326_XENTR Kcmf1 protein (Silurana tropicalis) 381 100.00% ORF Names:GSTENG00029614001 EMBL CAG08600.1OrganismTetraodon nigroviridis (Green puffer) ARP39397_P050 KCMF1_XENLA E3 ubiquitin‐protein ligase KCMF1 (EC 6.3.2.‐) Xenopus laevis (African clawed frog) 381 100.00%

ORF Names:v1g162049OrganismNematostel Xenopus tropicalis (Western clawed frog) la vectensis (Starlet sea anemone) ARP41576_T100 Q6DEY5_XENTR Formiminotransferase cyclodeaminase (Silurana tropicalis) 540 85.00%

ORF Names:v1g162049OrganismNematostel Xenopus tropicalis (Western clawed frog) la vectensis (Starlet sea anemone) ARP41576_T100 Q28EV1_XENTR Formiminotransferase cyclodeaminase (Silurana tropicalis) 540 85.00% Xenopus tropicalis (Western clawed frog) ACTN4 ARP42203_P050 Q6DFP7_XENTR Actinin, alpha 4 (Silurana tropicalis) 904 92.00% ACTN4 ARP42203_P050 Q6DCS8_XENLA Actn4‐prov protein Xenopus laevis (African clawed frog) 904 92.00% ORF Names:PANDA_015528 EMBL EFB22861.1OrganismAiluropoda melanoleuca (Giant panda) ARP34458_P050 Q5PPX2_XENLA LOC496053 protein Xenopus laevis (African clawed frog) 411 92.00% ORF Names:PANDA_015528 EMBL EFB22861.1OrganismAiluropoda melanoleuca (Giant panda) ARP34458_P050 Q2LE80_XENLA BTB domain protein 2 Xenopus laevis (African clawed frog) 543 92.00% Xenopus tropicalis (Western clawed frog) CBL9 ARP42334_P050 SEGN_XENTR Secretagogin (Silurana tropicalis) 271 100.00% CBL9 ARP42334_P050 SEGN_XENLA Secretagogin Xenopus laevis (African clawed frog) 271 100.00%

ORF Names:v1g99372OrganismNematostell Xenopus tropicalis (Western clawed frog) a vectensis (Starlet sea anemone) ARP45855_P050 Q00P39_XENTR Protein O‐fucosyltransferase 2 (Silurana tropicalis) 435 100.00% ORF Names:CpipJ_CPIJ007050 EMBL EDS28622.1OrganismCulex quinquefasciatus (Southern house Xenopus tropicalis (Western clawed frog) mosquito) (Culex pungens) ARP34572_T100 Q0IHN6_XENTR LOC779562 protein (Fragment) (Silurana tropicalis) 629 92.00% ORF Names:CpipJ_CPIJ007050 EMBL EDS28622.1OrganismCulex quinquefasciatus (Southern house mosquito) (Culex pungens) ARP34572_T100 B1H1T2_XENLA LOC100158298 protein Xenopus laevis (African clawed frog) 601 92.00%

ORF Names:IscW_ISCW012863 EMBL EEC16656.1OrganismIxodes scapularis Xenopus tropicalis (Western clawed frog) (Black‐legged tick) (Deer tick) ARP50259_P050 Q5BL85_XENTR Putative uncharacterized protein LOC548849 (Silurana tropicalis) 343 100.00% ORF Names:IscW_ISCW012863 EMBL EEC16656.1OrganismIxodes scapularis UDP‐Gal:betaGal beta 1,3‐ Xenopus tropicalis (Western clawed frog) (Black‐legged tick) (Deer tick) ARP50259_P050 Q28F44_XENTR galactosyltransferase polypeptide 6 (Silurana tropicalis) 343 100.00% 0610010K14Rik ARP53291_P050 Q6NUA8_XENLA MGC81096 protein Xenopus laevis (African clawed frog) 194 100.00% 0610010K14Rik ARP53291_P050 Q5I002_XENLA LOC496304 protein Xenopus laevis (African clawed frog) 164 100.00% Xenopus tropicalis (Western clawed frog) 0610010K14Rik ARP53291_P050 Q0VFS1_XENTR Putative uncharacterized protein MGC145240 (Silurana tropicalis) 198 100.00% ARP34122_T100 Q8UVU0_XENLA DNA ligase IV Xenopus laevis (African clawed frog) 911 85.00% ARP34122_T100 Q6GLS1_XENLA Lig4‐A protein Xenopus laevis (African clawed frog) 911 85.00% Xenopus tropicalis (Western clawed frog) ARP34122_T100 Q28EB8_XENTR Ligase IV, DNA, ATP‐dependent (Silurana tropicalis) 911 85.00% Xenopus tropicalis (Western clawed frog) SGCB ARP44244_P050 B3DM44_XENTR Putative uncharacterized protein (Silurana tropicalis) 309 85.00% SGCB ARP44244_P050 A8WH56_XENLA LOC100127262 protein Xenopus laevis (African clawed frog) 309 85.00% ARP47609_P050 Q66J61_XENLA MGC81811 protein Xenopus laevis (African clawed frog) 321 92.00% Xenopus tropicalis (Western clawed frog) ARP47609_P050 Q5U4Y3_XENTR Mortality factor 4 like 2 (Silurana tropicalis) 323 92.00% Xenopus tropicalis (Western clawed frog) ARP47609_P050 Q28EZ5_XENTR Mortality factor 4 like 1 (Silurana tropicalis) 323 92.00% Xenopus tropicalis (Western clawed frog) ARP46022_T100 ARP2_XENTR Actin‐related protein 2 (Actin‐like protein 2) (Silurana tropicalis) 394 100.00% Actin‐related protein 2‐B (Actin‐like protein 2‐ ARP46022_T100 ARP2B_XENLA B) Xenopus laevis (African clawed frog) 394 100.00% Actin‐related protein 2‐A (Actin‐like protein 2‐ ARP46022_T100 ARP2A_XENLA A) Xenopus laevis (African clawed frog) 394 100.00%

Ordered Locus Methionine adenosyltransferase 2 subunit Names:Shewana3_3709OrganismShew beta (Methionine adenosyltransferase II beta) Xenopus tropicalis (Western clawed frog) anella sp. (strain ANA‐3) ARP55850_P050 MAT2B_XENTR (MAT II beta) (Silurana tropicalis) 334 85.00%

Ordered Locus Methionine adenosyltransferase 2 subunit Names:Shewana3_3709OrganismShew beta (Methionine adenosyltransferase II beta) anella sp. (strain ANA‐3) ARP55850_P050 MAT2B_XENLA (MAT II beta) Xenopus laevis (African clawed frog) 334 85.00% ARP38863_T100 Q6NRT1_XENLA MGC81491 protein Xenopus laevis (African clawed frog) 778 92.00% Xenopus tropicalis (Western clawed frog) ARP38863_T100 B2GUN2_XENTR LOC100158621 protein (Silurana tropicalis) 778 85.00%

Serine/threonine‐protein phosphatase 4 Xenopus tropicalis (Western clawed frog) Ppx4 ARP58516_P050 PP4C_XENTR catalytic subunit (PP4C) (Pp4) (EC 3.1.3.16) (Silurana tropicalis) 307 100.00%

Serine/threonine‐protein phosphatase 4 Ppx4 ARP58516_P050 PP4C_XENLA catalytic subunit (PP4C) (Pp4) (EC 3.1.3.16) Xenopus laevis (African clawed frog) 307 100.00% PPP3CA ARP51338_P050 Q801N4_XENLA Ppp3ca‐prov protein Xenopus laevis (African clawed frog) 518 100.00% PPP3CA ARP51338_P050 O57438_XENLA Calcineurin A Xenopus laevis (African clawed frog) 518 100.00% Xenopus tropicalis (Western clawed frog) PPP3CA ARP51338_P050 B0BLZ8_XENTR LOC100144934 protein (Silurana tropicalis) 521 100.00% PPP3CA ARP51338_P050 Q9DEF7_XENLA Calcineurin catalytic subunit Xenopus laevis (African clawed frog) 508 100.00% PPP3CA ARP51338_P050 Q6AXB0_XENLA MGC79144 protein Xenopus laevis (African clawed frog) 511 100.00% Paired‐like homeodomain transcription factor ARP33033_P050 B7ZRH8_XENLA 3 (Pitx3 protein) Xenopus laevis (African clawed frog) 292 84.00%

Pituitary homeobox 3 (Homeobox protein PITX3) (XPitx‐3) (xPitx3) (Paired‐like ARP33033_P050 PITX3_XENLA homeodomain transcription factor 3) Xenopus laevis (African clawed frog) 292 84.00% Gna13 ARP54813_P050 Q5HZN4_XENLA LOC496349 protein Xenopus laevis (African clawed frog) 377 76.00% Xenopus tropicalis (Western clawed frog) Gna13 ARP54813_P050 B1H2U7_XENTR LOC100145489 protein (Silurana tropicalis) 377 76.00%

ORF Names:GSTENG00032084001 EMBL CAG10438.1OrganismTetraodon nigroviridis (Green puffer) ARP38418_P050 Q9IB10_XENLA Transcription factor E2F Xenopus laevis (African clawed frog) 429 81.00%

ORF Names:GSTENG00032084001 EMBL CAG10438.1OrganismTetraodon Xenopus tropicalis (Western clawed frog) nigroviridis (Green puffer) ARP38418_P050 Q5XGD5_XENTR E2F transcription factor 3 (Silurana tropicalis) 427 81.00%

ORF Names:GSTENG00032084001 EMBL CAG10438.1OrganismTetraodon nigroviridis (Green puffer) ARP38418_P050 Q4V880_XENLA LOC398159 protein Xenopus laevis (African clawed frog) 429 81.00% Zinc finger CCCH‐type with G patch domain‐ Xenopus tropicalis (Western clawed frog) zgpat ARP42680_P050 ZGPAT_XENTR containing protein (Silurana tropicalis) 514 90.00% Eif2s3x ARP46057_P050 Q7ZY57_XENLA Eif2s3‐prov protein Xenopus laevis (African clawed frog) 472 92.00% Eukaryotic translation initiation factor 2, Xenopus tropicalis (Western clawed frog) Eif2s3x ARP46057_P050 Q5I098_XENTR subunit 3 gamma, 52kDa (Silurana tropicalis) 472 92.00% Xenopus tropicalis (Western clawed frog) MSL3L1 ARP39784_T100 Q28I09_XENTR Male‐specific lethal 3‐like 1 (Silurana tropicalis) 354 84.00% MSL3L1 ARP39784_T100 Q5XK98_XENLA LOC494864 protein Xenopus laevis (African clawed frog) 355 76.00% ORF Names:CpipJ_CPIJ013983 EMBL EDS39365.1OrganismCulex quinquefasciatus (Southern house mosquito) (Culex pungens) ARP58455_P050 Q7T0W0_XENLA Dld protein Xenopus laevis (African clawed frog) 509 92.00% COP9 signalosome complex subunit 5 Xenopus tropicalis (Western clawed frog) COPS5 ARP31512_P050 CSN5_XENTR (Signalosome subunit 5) (EC 3.4.‐.‐) (Silurana tropicalis) 334 92.00% COP9 signalosome complex subunit 5 COPS5 ARP31512_P050 CSN5_XENLA (Signalosome subunit 5) (EC 3.4.‐.‐) Xenopus laevis (African clawed frog) 332 92.00% Iroquois‐class homeodomain protein irx‐4 Xenopus tropicalis (Western clawed frog) IRX4 ARP32066_T100 IRX4_XENTR (Iroquois homeobox protein 4) (Silurana tropicalis) 496 78.00% Iroquois‐class homeodomain protein irx‐4‐A IRX4 ARP32066_T100 IRX4A_XENLA (Iroquois homeobox protein 4‐A) Xenopus laevis (African clawed frog) 496 78.00%

ORF Names:CH211‐206A7.1‐001 EMBL CAN88761.1OrganismDanio rerio (Zebrafish) (Brachydanio rerio) ARP40412_T100 Q6P9H8_XENLA MGC69160 protein Xenopus laevis (African clawed frog) 346 100.00%

ORF Names:CH211‐206A7.1‐001 EMBL CAN88761.1OrganismDanio rerio Ppp1r8 protein (Protein phosphatase 1, Xenopus tropicalis (Western clawed frog) (Zebrafish) (Brachydanio rerio) ARP40412_T100 Q28G86_XENTR regulatory (Inhibitor) subunit 8) (Silurana tropicalis) 346 100.00%

ORF Names:CH211‐206A7.1‐001 EMBL CAN88761.1OrganismDanio rerio (Zebrafish) (Brachydanio rerio) ARP40412_T100 Q05AU6_XENLA Ppp1r8_predicted protein Xenopus laevis (African clawed frog) 346 100.00%

ORF Names:zgc:158643 ZFIN ZDB‐GENE‐ 070112‐2132OrganismDanio rerio N‐ethylmaleimide‐sensitive factor attachment Xenopus tropicalis (Western clawed frog) (Zebrafish) (Brachydanio rerio) AVARP13077_P050 Q05B34_XENTR protein, beta (Silurana tropicalis) 296 100.00% zranb2 ARP35779_P050 Q91708_XENLA C4SR protein Xenopus laevis (African clawed frog) 337 85.00% zranb2 ARP35779_P050 A3KND4_XENLA C4SR protein Xenopus laevis (African clawed frog) 337 85.00% zranb2 ARP35779_P050 Q5XGW8_XENLA LOC495123 protein Xenopus laevis (African clawed frog) 344 78.00% Xenopus tropicalis (Western clawed frog) zranb2 ARP35779_P050 B4F729_XENTR Putative uncharacterized protein (Silurana tropicalis) 356 78.00% Thyroid hormone receptor‐associated protein 3 (Thyroid hormone receptor‐associated protein complex 150 kDa component) Thrap3 ARP38565_P050 TR150_XENLA (Trap150) Xenopus laevis (African clawed frog) 951 100.00% Epha7 ARP58460_P050 Q7ZYM7_XENLA Pag protein Xenopus laevis (African clawed frog) 986 100.00% Xenopus tropicalis (Western clawed frog) Epha7 ARP58460_P050 B4F704_XENTR Putative uncharacterized protein (Silurana tropicalis) 985 100.00% Ephrin type‐A receptor 4‐B (EC 2.7.10.1) (Pagliaccio) (Tyrosine‐protein kinase receptor Epha7 ARP58460_P050 EPA4B_XENLA PAG) Xenopus laevis (African clawed frog) 985 100.00% Ephrin type‐A receptor 4‐A (EC 2.7.10.1) (Tyrosine‐protein kinase receptor SEK‐1) (xSEK‐ Epha7 ARP58460_P050 EPA4A_XENLA 1) Xenopus laevis (African clawed frog) 986 100.00% Epha7 ARP58460_P050 Q9PWR5_XENLA Eph receptor tyrosine kinase Xenopus laevis (African clawed frog) 977 85.00% Epha7 ARP58460_P050 Q91999_XENLA G42 protein (G50 protein) (Fragment) Xenopus laevis (African clawed frog) 57 85.00% Epha7 ARP58460_P050 Q6NTV5_XENLA Putative uncharacterized protein Xenopus laevis (African clawed frog) 978 85.00% Xenopus tropicalis (Western clawed frog) Epha7 ARP58460_P050 Q6DII4_XENTR EphA2 (Silurana tropicalis) 974 85.00% Epha7 ARP58460_P050 Q5FWW9_XENLA Epha2‐A protein Xenopus laevis (African clawed frog) 963 85.00% Epha7 ARP58460_P050 Q91564_XENLA E17 protein (Fragment) Xenopus laevis (African clawed frog) 57 85.00% ppwd1 ARP55238_P050 A1L3F6_XENLA LOC100036992 protein Xenopus laevis (African clawed frog) 642 92.00% RE1‐silencing transcription factor A (Neural‐ Rest ARP32478_P050 RESTA_XENLA restrictive factor A) Xenopus laevis (African clawed frog) 1501 85.00% HNRNPU ARP40519_P050 Q9YHY5_XENLA Scaffold attachment factor A Xenopus laevis (African clawed frog) 774 100.00% HNRNPU ARP40519_P050 Q5U5E2_XENLA Saf‐A protein Xenopus laevis (African clawed frog) 772 100.00% HNRNPU ARP40519_P050 Q7ZTJ7_XENLA Hnrnpu protein (Fragment) Xenopus laevis (African clawed frog) 555 92.00% Xenopus tropicalis (Western clawed frog) HNRNPU ARP40519_P050 Q6DEQ1_XENTR HNRPU protein (Fragment) (Silurana tropicalis) 203 92.00%

Heterogeneous nuclear ribonucleoprotein U Xenopus tropicalis (Western clawed frog) HNRNPU ARP40519_P050 Q28DK6_XENTR (Scaffold attachment factor A) (Silurana tropicalis) 790 92.00% Xenopus tropicalis (Western clawed frog) HNRNPU ARP40519_P050 B3DM03_XENTR Hnrnpu protein (Silurana tropicalis) 784 92.00% Xenopus tropicalis (Western clawed frog) HNRNPU ARP40519_P050 A4II53_XENTR HNRPU protein (Fragment) (Silurana tropicalis) 194 92.00% Xenopus tropicalis (Western clawed frog) SURF4 ARP50161_P050 Q6P344_XENTR Surfeit gene 4 (Silurana tropicalis) 269 100.00% SURF4 ARP50161_P050 Q6NTY0_XENLA MGC81440 protein Xenopus laevis (African clawed frog) 269 100.00% SURF4 ARP50161_P050 Q6GQF8_XENLA MGC80096 protein Xenopus laevis (African clawed frog) 269 92.00% SURF4 ARP50161_P050 Q6AZP7_XENLA MGC82578 protein Xenopus laevis (African clawed frog) 269 78.00% Xenopus tropicalis (Western clawed frog) SURF4 ARP50161_P050 Q642N6_XENTR Surf4 protein (Silurana tropicalis) 269 78.00% Xenopus tropicalis (Western clawed frog) SURF4 ARP50161_P050 Q28IU7_XENTR Novell gene similar to surfeit 4 (Silurana tropicalis) 269 78.00% Xenopus tropicalis (Western clawed frog) thyA ARP48543_P050 Q0IHX3_XENTR Thymidylate synthetase (Silurana tropicalis) 308 78.00% Xenopus tropicalis (Western clawed frog) ETV6 P100806_P050 Q28DU7_XENTR Ets variant gene 6 (TEL oncogene) (Silurana tropicalis) 450 92.00% Xenopus tropicalis (Western clawed frog) ETV6 P100806_P050 Q0IHQ4_XENTR Ets variant 6 (Silurana tropicalis) 450 92.00% ETV6 P100806_P050 B3VKU4_XENLA Ets variant 6 Xenopus laevis (African clawed frog) 448 92.00% ARP40206_T100 A2BDA6_XENLA LOC100037084 protein Xenopus laevis (African clawed frog) 423 85.00%

ORF Names:CH211‐136O4.4‐001 EMBL CAP09307.1OrganismDanio rerio (Zebrafish) (Brachydanio rerio) ARP51959_P050 Q6PB02_XENLA MGC68668 protein Xenopus laevis (African clawed frog) 573 85.00%

ORF Names:CH211‐136O4.4‐001 EMBL CAP09307.1OrganismDanio rerio Xenopus tropicalis (Western clawed frog) (Zebrafish) (Brachydanio rerio) ARP51959_P050 B2GUD4_XENTR LOC100158561 protein (Silurana tropicalis) 656 85.00% ORF Names:CH211‐136O4.4‐001 EMBL CAP09307.1OrganismDanio rerio ‐related protein 3 (DRP‐ Xenopus tropicalis (Western clawed frog) (Zebrafish) (Brachydanio rerio) ARP51959_P050 DPYL3_XENTR 3) (Dihydropyrimidinase‐like 3) (Silurana tropicalis) 571 78.00%

ORF Names:CH211‐136O4.4‐001 EMBL CAP09307.1OrganismDanio rerio Dihydropyrimidinase‐related protein 3‐A (DRP‐ (Zebrafish) (Brachydanio rerio) ARP51959_P050 DPY3A_XENLA 3‐A) (Neural‐specific protein 1) Xenopus laevis (African clawed frog) 571 78.00% Ordered Locus Names:Gura_0643OrganismGeobacter uraniireducens (strain Rf4) (Geobacter uraniumreducens) ARP40249_T100 Q7ZYA4_XENLA Sf3b1 protein (Fragment) Xenopus laevis (African clawed frog) 500 100.00% Ordered Locus Names:Gura_0643OrganismGeobacter uraniireducens (strain Rf4) (Geobacter uraniumreducens) ARP40249_T100 Q4QR12_XENLA Sf3b1 protein Xenopus laevis (African clawed frog) 814 100.00% Ordered Locus Names:Gura_0643OrganismGeobacter uraniireducens (strain Rf4) (Geobacter Xenopus tropicalis (Western clawed frog) uraniumreducens) ARP40249_T100 A7MC63_XENTR LOC100127558 protein (Fragment) (Silurana tropicalis) 496 100.00%

Ordered Locus Splicing factor 3B subunit 1 (146 kDa nuclear Names:Gura_0643OrganismGeobacter protein) (Pre‐mRNA‐splicing factor SF3b 155 uraniireducens (strain Rf4) (Geobacter kDa subunit) (SF3b155) (Spliceosome‐ uraniumreducens) ARP40249_T100 SF3B1_XENLA associated protein 155) (SAP 155) Xenopus laevis (African clawed frog) 1307 100.00% Xenopus tropicalis (Western clawed frog) sptan1 ARP58532_P050 A0JPA2_XENTR LOC100036647 protein (Silurana tropicalis) 2471 100.00% D4, zinc and double PHD fingers family 2 Xenopus tropicalis (Western clawed frog) ARP33221_P050 Q28IH5_XENTR (Fragment) (Silurana tropicalis) 298 85.00% ARP33221_P050 Q6IRM6_XENLA LOC397786 protein Xenopus laevis (African clawed frog) 387 91.00% Zinc finger protein ubi‐d4 B (Apoptosis response zinc finger protein B) (Protein ARP33221_P050 REQUB_XENLA requiem B) (xReq B) (Fragment) Xenopus laevis (African clawed frog) 366 91.00% Zinc finger protein ubi‐d4 A (Apoptosis response zinc finger protein A) (Protein ARP33221_P050 REQUA_XENLA requiem A) (xReq A) Xenopus laevis (African clawed frog) 388 91.00% Protein LSM14 homolog A (RNA‐associated Xenopus tropicalis (Western clawed frog) lsm14a‐a ARP55289_P050 LS14A_XENTR protein 55A) (RAP55A) (Silurana tropicalis) 469 92.00% Protein LSM14 homolog A‐B (RNA‐associated lsm14a‐a ARP55289_P050 L14AB_XENLA protein 55A‐B) (RAP55A‐B) Xenopus laevis (African clawed frog) 471 92.00% Protein LSM14 homolog A‐A (RNA‐associated protein 55A‐A) (RAP55A‐A) (xRAP55) lsm14a‐a ARP55289_P050 L14AA_XENLA (xRAP55A) Xenopus laevis (African clawed frog) 471 85.00% Xenopus tropicalis (Western clawed frog) wnt16 ARP41268_T100 A4ZGN9_XENTR Wnt16 (Silurana tropicalis) 376 78.00% ORF Names:CC1G_08933 EMBL EAU82996.1OrganismCoprinopsis cinerea (strain Okayama‐7 / 130 / FGSC 9003) (Inky cap fungus) (Hormographiella aspergillata) ARP45708_P050 Q6AZJ0_XENLA Glud1‐prov protein Xenopus laevis (African clawed frog) 540 92.00% ORF Names:CC1G_08933 EMBL EAU82996.1OrganismCoprinopsis cinerea (strain Okayama‐7 / 130 / FGSC 9003) (Inky cap fungus) Xenopus tropicalis (Western clawed frog) (Hormographiella aspergillata) ARP45708_P050 Q5XGI4_XENTR Glutamate dehydrogenase 1 (Silurana tropicalis) 540 92.00% Xenopus tropicalis (Western clawed frog) Gcg ARP42010_T100 Q6DIZ4_XENTR Glucagon (Silurana tropicalis) 266 100.00% Gcg ARP42010_T100 B7ZQU9_XENLA Putative uncharacterized protein Xenopus laevis (African clawed frog) 219 100.00% Gcg ARP42010_T100 GLUC1_XENLA Isoform 2 Xenopus laevis (African clawed frog) 218 100.00% Glucagon‐2 (Glucagon II) [Cleaved into: Glucagon; Glucagon‐like peptide 1A (GLP‐1A); Glucagon‐like peptide 1B (GLP‐1B); Glucagon‐ Gcg ARP42010_T100 GLUC2_XENLA like peptide 1C (GLP‐1C)] Xenopus laevis (African clawed frog) 219 100.00% Glucagon‐1 (Glucagon I) [Cleaved into: Glucagon; Glucagon‐like peptide 1A (GLP‐1A); Glucagon‐like peptide 1B (GLP‐1B); Glucagon‐ like peptide 1C (GLP‐1C); Glucagon‐like Gcg ARP42010_T100 GLUC1_XENLA peptide 2 (GLP‐2)] Xenopus laevis (African clawed frog) 266 100.00% ARP46012_P050 Q6INK9_XENLA MGC82401 protein Xenopus laevis (African clawed frog) 609 92.00% Xenopus tropicalis (Western clawed frog) CH211‐106H4.1 P100920_P050 B2GUC3_XENTR protein (Silurana tropicalis) 371 92.00% ORF Names:PICST_31207 EMBL ABN65970.2OrganismPichia stipitis Acidic (Leucine‐rich) nuclear phosphoprotein Xenopus tropicalis (Western clawed frog) (Yeast) ARP46349_P050 Q28BK6_XENTR 32 family, member E (Silurana tropicalis) 264 85.00% ORF Names:PICST_31207 EMBL ABN65970.2OrganismPichia stipitis Xenopus tropicalis (Western clawed frog) (Yeast) ARP46349_P050 B1H1Z2_XENTR Putative uncharacterized protein (Silurana tropicalis) 189 85.00% ORF Names:PICST_31207 EMBL ABN65970.2OrganismPichia stipitis Acidic leucine‐rich nuclear phosphoprotein 32 (Yeast) ARP46349_P050 AN32E_XENLA family member E Xenopus laevis (African clawed frog) 263 85.00% ORF Names:PICST_31207 EMBL ABN65970.2OrganismPichia stipitis (Yeast) ARP46349_P050 Q505N1_XENLA MGC114736 protein Xenopus laevis (African clawed frog) 263 81.00%

Lema_P011050.1 ARP40276_T100 Q66J82_XENLA Putative uncharacterized protein (Fragment) Xenopus laevis (African clawed frog) 267 100.00% Lema_P011050.1 ARP40276_T100 Q4V7U3_XENLA LOC397946 protein (Fragment) Xenopus laevis (African clawed frog) 351 100.00% Lema_P011050.1 ARP40276_T100 Q32NW5_XENLA LOC397946 protein Xenopus laevis (African clawed frog) 471 100.00%

U1 small nuclear ribonucleoprotein 70 kDa Xenopus tropicalis (Western clawed frog) Lema_P011050.1 ARP40276_T100 RU17_XENTR (U1 snRNP 70 kDa) (U1‐70K) (snRNP70) (Silurana tropicalis) 471 100.00%

U1 small nuclear ribonucleoprotein 70 kDa Lema_P011050.1 ARP40276_T100 RU17_XENLA (U1 snRNP 70 kDa) (U1‐70K) (snRNP70) Xenopus laevis (African clawed frog) 471 100.00% Xenopus tropicalis (Western clawed frog) TMPO ARP44798_P050 Q6P846_XENTR Thymopoietin (Silurana tropicalis) 452 92.00% TMPO ARP44798_P050 Q9YGK9_XENLA Lamina associated polypeptide 2 Xenopus laevis (African clawed frog) 518 85.00% TMPO ARP44798_P050 Q7ZWN7_XENLA MGC53918 protein Xenopus laevis (African clawed frog) 206 85.00%

TMPO ARP44798_P050 Q4LDN2_XENLA Lamina associated protein 2‐beta isoform Xenopus laevis (African clawed frog) 520 85.00% TMPO ARP44798_P050 Q32N69_XENLA LAP2 protein Xenopus laevis (African clawed frog) 337 85.00%

Lamina associated protein 2‐beta isoform TMPO ARP44798_P050 O73766_XENLA (Lamina‐associated polypeptide 2 omega) Xenopus laevis (African clawed frog) 557 85.00% URA1 ARP41940_T100 Q6IR81_XENLA LOC432093 protein (Fragment) Xenopus laevis (African clawed frog) 406 85.00% URA1 ARP41940_T100 Q4QR42_XENLA LOC432093 protein Xenopus laevis (African clawed frog) 404 85.00% Xenopus tropicalis (Western clawed frog) URA1 ARP41940_T100 Q5BKN2_XENTR MGC107816 protein (Silurana tropicalis) 401 85.00% ARP45624_P050 Q8JJ28_XENLA Orphan nuclear receptor FOR1 Xenopus laevis (African clawed frog) 513 76.00% ARP45624_P050 Q6P7H5_XENLA MGC68693 protein Xenopus laevis (African clawed frog) 503 76.00% Nr1h5 protein (Nuclear receptor subfamily 1, Xenopus tropicalis (Western clawed frog) ARP45624_P050 A9ULH5_XENTR group H, member 5) (Silurana tropicalis) 513 76.00% Xenopus tropicalis (Western clawed frog) lass2 ARP39537_P050 A1L1E5_XENTR Lass2 protein (Silurana tropicalis) 378 92.00% ORF Names:PANDA_016586 EMBL EFB16662.1OrganismAiluropoda melanoleuca (Giant panda) ARP54676_P050 Q6NS18_XENLA MGC78839 protein Xenopus laevis (African clawed frog) 520 78.00% Xenopus tropicalis (Western clawed frog) SRFBP1 ARP50805_P050 SRFB1_XENTR Isoform 2 (Silurana tropicalis) 530 75.00% ‐binding protein 1 (SRF‐ dependent transcription regulation‐associated Xenopus tropicalis (Western clawed frog) SRFBP1 ARP50805_P050 SRFB1_XENTR protein) (Silurana tropicalis) 535 75.00% SRFBP1 ARP50805_P050 Q7T0Y3_XENLA Flj25286‐prov protein Xenopus laevis (African clawed frog) 480 75.00% Echinoderm microtubule‐associated protein‐ Xenopus tropicalis (Western clawed frog) EML4 ARP51803_P050 EMAL4_XENTR like 4 (EMAP‐4) (Silurana tropicalis) 928 92.00% Echinoderm microtubule‐associated protein‐ EML4 ARP51803_P050 EMAL4_XENLA like 4 (EMAP‐4) Xenopus laevis (African clawed frog) 927 84.00% Xenopus tropicalis (Western clawed frog) TMX4 ARP49631_P050 B5DFR6_XENTR Putative uncharacterized protein (Silurana tropicalis) 532 81.00% ORF Names:Smp_020050 EMBL CAZ29688.1OrganismSchistosoma Xenopus tropicalis (Western clawed frog) mansoni (Blood fluke) ARP38431_T100 Q5EB36_XENTR MGC97656 protein (Silurana tropicalis) 443 100.00% ORF Names:Smp_020050 EMBL CAZ29688.1OrganismSchistosoma mansoni (Blood fluke) ARP38431_T100 Q2VPH6_XENLA LOC432342 protein Xenopus laevis (African clawed frog) 443 100.00% ORF Names:Smp_020050 EMBL CAZ29688.1OrganismSchistosoma COP9 signalosome complex subunit 2 mansoni (Blood fluke) ARP38431_T100 CSN2_XENLA (Signalosome subunit 2) (Fragment) Xenopus laevis (African clawed frog) 441 100.00% Xenopus tropicalis (Western clawed frog) Usp48 ARP44805_T100 B0JZH0_XENTR LOC100145207 protein (Silurana tropicalis) 1039 78.00% rps14 ARP40322_T100 Q6PI76_XENLA Rps14‐prov protein Xenopus laevis (African clawed frog) 151 100.00% Xenopus tropicalis (Western clawed frog) rps14 ARP40322_T100 A4IGS7_XENTR Putative uncharacterized protein LOC549476 (Silurana tropicalis) 151 100.00% Cre‐ccdc‐55 ARP38921_P050 Q2TAH7_XENLA Putative uncharacterized protein Xenopus laevis (African clawed frog) 508 92.00% Cre‐ccdc‐55 ARP38921_P050 B7ZQW8_XENLA SUPT16H protein Xenopus laevis (African clawed frog) 1035 92.00% FACT complex subunit SPT16 (DNA unwinding factor 140 kDa subunit) (DUF140) (Facilitates chromatin transcription complex subunit Cre‐ccdc‐55 ARP38921_P050 SP16H_XENLA spt16) Xenopus laevis (African clawed frog) 1035 92.00% ORF Names:LELG_04299 EMBL EDK46119.1OrganismLodderomyces elongisporus (Yeast) (Saccharomyces elongisporus) ARP48186_T100 Q7ZWR6_XENLA Atp5b protein Xenopus laevis (African clawed frog) 525 85.00% ORF Names:LELG_04299 EMBL EDK46119.1OrganismLodderomyces elongisporus (Yeast) (Saccharomyces ATP synthase, H+ transporting, mitochondrial Xenopus tropicalis (Western clawed frog) elongisporus) ARP48186_T100 Q6NWX0_XENTR F1 complex, beta polypeptide (Silurana tropicalis) 525 85.00% Protein arginine N‐methyltransferase 7 (EC 2.1.1.‐) (Histone‐arginine N‐methyltransferase PRMT7) (EC 2.1.1.125) ([Myelin basic protein]‐ arginine N‐methyltransferase PRMT7) (EC prmt7 ARP40191_P050 ANM7_XENLA 2.1.1.126) Xenopus laevis (African clawed frog) 685 100.00% Nudc ARP52205_P050 Q6IRP6_XENLA MGC83068 protein Xenopus laevis (African clawed frog) 329 100.00% Nudc ARP52205_P050 Q640C9_XENLA LOC494725 protein Xenopus laevis (African clawed frog) 327 100.00% ORF Names:Bm1_39220 EMBL EDP32106.1OrganismBrugia malayi Alpha‐1,6‐mannosyl‐glycoprotein 2‐beta‐N‐ (Filarial nematode worm) ARP44702_P050 Q7ZZX7_XENLA acetylglucosaminyltransferase Xenopus laevis (African clawed frog) 432 84.00% ORF Names:Bm1_39220 EMBL EDP32106.1OrganismBrugia malayi (Filarial nematode worm) ARP44702_P050 Q6GLT2_XENLA MGC84280 protein Xenopus laevis (African clawed frog) 432 84.00% ORF Names:Bm1_39220 EMBL EDP32106.1OrganismBrugia malayi Mannosyl (Alpha‐1,6‐)‐glycoprotein beta‐1,2‐ Xenopus tropicalis (Western clawed frog) (Filarial nematode worm) ARP44702_P050 Q6DIJ6_XENTR N‐acetylglucosaminyltransferase (Silurana tropicalis) 432 100.00% ORF Names:Bm1_39220 EMBL EDP32106.1OrganismBrugia malayi Mannosyl (Alpha‐1,6‐)‐glycoprotein beta‐1,2‐ Xenopus tropicalis (Western clawed frog) (Filarial nematode worm) ARP44702_P050 Q28HY1_XENTR N‐acetylglucosaminyltransferase (Silurana tropicalis) 432 100.00% ORF Names:Bm1_39220 EMBL EDP32106.1OrganismBrugia malayi (Filarial nematode worm) ARP44702_P050 Q6NTL2_XENLA MGC83215 protein Xenopus laevis (African clawed frog) 432 90.00% ORF Names:Bm1_39220 EMBL Mannosyl alpha‐1,6‐‐glycoprotein beta‐1,2‐N‐ EDP32106.1OrganismBrugia malayi acetylglucosaminyltransferase alpha (Filarial nematode worm) ARP44702_P050 B2L4G4_XENBO (Fragment) Xenopus borealis (Kenyan clawed frog) 34 90.00% lmnb2 ARP46357_P050 Q6GPC2_XENLA Lmnb2‐A‐prov protein Xenopus laevis (African clawed frog) 624 100.00% lmnb2 ARP46357_P050 Q6DDM6_XENLA LOC397912 protein Xenopus laevis (African clawed frog) 623 100.00% lmnb2 ARP46357_P050 O93399_XENLA Lamin B2 (Fragment) Xenopus laevis (African clawed frog) 561 100.00% lmnb2 ARP46357_P050 LAML2_XENLA Lamin‐L(II) Xenopus laevis (African clawed frog) 623 100.00% ARP46596_P050 Q6W9J2_XENLA Hyaluronic acid synthase 3 Xenopus laevis (African clawed frog) 557 92.00% Xenopus tropicalis (Western clawed frog) ARP46596_P050 B1WAU6_XENTR Has2 protein (Silurana tropicalis) 552 85.00% Hyaluronan synthase 2 (EC 2.4.1.212) (Hyaluronate synthase 2) (Hyaluronic acid ARP46596_P050 HAS2_XENLA synthase 2) (HA synthase 2) (xHAS2) Xenopus laevis (African clawed frog) 551 85.00% ARP32839_P050 Q8AVC8_XENLA LOC397919 protein (Fragment) Xenopus laevis (African clawed frog) 370 90.00%

ARP32839_P050 Q6GQE3_XENLA Putative uncharacterized protein (Fragment) Xenopus laevis (African clawed frog) 371 90.00%

ARP32839_P050 Q3KPL2_XENLA Putative uncharacterized protein (Fragment) Xenopus laevis (African clawed frog) 370 90.00% ARP32839_P050 Q06459_XENLA Nucleolin Xenopus laevis (African clawed frog) 705 90.00% ARP32839_P050 B7ZR98_XENLA LOC397919 protein Xenopus laevis (African clawed frog) 704 90.00% ARP32839_P050 B7ZR96_XENLA LOC397919 protein Xenopus laevis (African clawed frog) 704 90.00%

ARP32839_P050 A9ULV9_XENLA Putative uncharacterized protein (Fragment) Xenopus laevis (African clawed frog) 371 90.00%

ARP32839_P050 A1A645_XENLA Putative uncharacterized protein (Fragment) Xenopus laevis (African clawed frog) 371 90.00% ARP32839_P050 Q9PVV6_XENLA TAF‐Ibeta1 Xenopus laevis (African clawed frog) 278 76.00% Xenopus tropicalis (Western clawed frog) ARP43827_P050 A4IIF3_XENTR LOC100124992 protein (Silurana tropicalis) 537 78.00% ZNF526 ARP32148_P050 Q7T0V1_XENLA LOC398684 protein (Fragment) Xenopus laevis (African clawed frog) 653 100.00% Xenopus tropicalis (Western clawed frog) ZNF526 ARP32148_P050 ZN574_XENTR Zinc finger protein 574 (Silurana tropicalis) 857 100.00% Xenopus tropicalis (Western clawed frog) ZNF526 ARP32148_P050 B0JZG5_XENTR LOC100145203 protein (Silurana tropicalis) 919 90.00% PGK1 ARP48140_P050 Q6DD48_XENLA Pgk2 protein Xenopus laevis (African clawed frog) 417 92.00% PGK1 ARP48140_P050 Q7ZYH7_XENLA Pgk1‐prov protein Xenopus laevis (African clawed frog) 417 85.00% Xenopus tropicalis (Western clawed frog) var ARP40472_P050 Q28GT0_XENTR Tyrosyl‐tRNA synthetase (Fragment) (Silurana tropicalis) 241 76.00%

Tyrosyl‐tRNA synthetase, cytoplasmic (EC Xenopus tropicalis (Western clawed frog) var ARP40472_P050 SYYC_XENTR 6.1.1.1) (Tyrosyl‐‐tRNA ligase) (TyrRS) (Silurana tropicalis) 528 76.00%

Tyrosyl‐tRNA synthetase, cytoplasmic (EC var ARP40472_P050 SYYC_XENLA 6.1.1.1) (Tyrosyl‐‐tRNA ligase) (TyrRS) Xenopus laevis (African clawed frog) 528 76.00% JUND ARP38134_P050 Q9PVZ1_XENLA C‐Jun protein Xenopus laevis (African clawed frog) 312 85.00% JUND ARP38134_P050 Q8AVE4_XENLA Jun protein Xenopus laevis (African clawed frog) 312 85.00% JUND ARP38134_P050 Q68FJ3_XENLA MGC86303 protein Xenopus laevis (African clawed frog) 299 78.00% JUND ARP38134_P050 Q9PVZ0_XENLA C‐Jun protein Xenopus laevis (African clawed frog) 314 78.00% JUND ARP38134_P050 Q91714_XENLA C‐jun protein (Fragment) Xenopus laevis (African clawed frog) 71 78.00% JUND ARP38134_P050 Q6GLS7_XENLA C‐Jun protein Xenopus laevis (African clawed frog) 314 78.00% Xenopus tropicalis (Western clawed frog) slc9a7 ARP44066_P050 B2GUM7_XENTR Slc9a7 protein (Silurana tropicalis) 673 92.00% ORF Names:GSPATT00004487001 EMBL CAK56393.1OrganismParamecium Mgc108129 protein (Putative uncharacterized Xenopus tropicalis (Western clawed frog) tetraurelia ARP34376_T100 Q4VA70_XENTR protein mgc108129) (Silurana tropicalis) 434 92.00% ORF Names:GSPATT00004487001 EMBL CAK56393.1OrganismParamecium Xenopus tropicalis (Western clawed frog) tetraurelia ARP34376_T100 Q6P8E1_XENTR Enolase 1, (Alpha) (Silurana tropicalis) 434 92.00% ORF Names:GSPATT00004487001 EMBL CAK56393.1OrganismParamecium Xenopus tropicalis (Western clawed frog) tetraurelia ARP34376_T100 B0BMH7_XENTR Eno1 protein (Silurana tropicalis) 434 92.00% ORF Names:GSPATT00004487001 EMBL CAK56393.1OrganismParamecium tetraurelia ARP34376_T100 A1L3K7_XENLA LOC100037034 protein Xenopus laevis (African clawed frog) 434 92.00% ORF Names:GSPATT00004487001 EMBL CAK56393.1OrganismParamecium tetraurelia ARP34376_T100 Q7ZXA3_XENLA Eno3‐prov protein Xenopus laevis (African clawed frog) 434 92.00% ORF Names:GSPATT00004487001 EMBL CAK56393.1OrganismParamecium tetraurelia ARP34376_T100 Q8AVT0_XENLA MGC53543 protein Xenopus laevis (African clawed frog) 434 85.00% ORF Names:GSPATT00004487001 EMBL CAK56393.1OrganismParamecium tetraurelia ARP34376_T100 Q7SZ25_XENLA Eno1‐prov protein Xenopus laevis (African clawed frog) 434 85.00% ORF Names:GSPATT00004487001 EMBL Alpha‐enolase (EC 4.2.1.11) (2‐phospho‐D‐ CAK56393.1OrganismParamecium glycerate hydro‐lyase) (2‐phosphoglycerate tetraurelia ARP34376_T100 ENOA_XENLA dehydratase) Xenopus laevis (African clawed frog) 434 85.00% ORF Names:GSPATT00036496001 EMBL CAK67716.1OrganismParamecium tetraurelia ARP33951_P050 Q6GQA2_XENLA LOC443585 protein (Fragment) Xenopus laevis (African clawed frog) 1388 78.00% ORF Names:GSPATT00036496001 EMBL CAK67716.1OrganismParamecium tetraurelia ARP33951_P050 Q63ZQ9_XENLA LOC494751 protein Xenopus laevis (African clawed frog) 2234 83.00% Xenopus tropicalis (Western clawed frog) CREB ARP38574_P050 Q6DJ07_XENTR Activating transcription factor 1 (Silurana tropicalis) 281 84.00% CREB ARP38574_P050 Q5HZP0_XENLA LOC496344 protein Xenopus laevis (African clawed frog) 280 84.00% CREB ARP38574_P050 Q58E78_XENLA MGC85066 protein Xenopus laevis (African clawed frog) 279 84.00% CREB ARP38574_P050 Q8AVY5_XENLA Creb1‐prov protein Xenopus laevis (African clawed frog) 324 78.00% Xenopus tropicalis (Western clawed frog) CREB ARP38574_P050 Q6NVP9_XENTR cAMP responsive element binding protein 1 (Silurana tropicalis) 327 78.00%

ORF Names:v1g193516OrganismNematostel la vectensis (Starlet sea anemone) ARP56462_P050 Q6NRC2_XENLA MGC84496 protein Xenopus laevis (African clawed frog) 199 92.00%

ORF Names:v1g193516OrganismNematostel la vectensis (Starlet sea anemone) ARP56462_P050 Q6GQ40_XENLA MGC80364 protein Xenopus laevis (African clawed frog) 199 84.00%

ORF Names:v1g193516OrganismNematostel Hypothetical LOC496467 (Proteasome Xenopus tropicalis (Western clawed frog) la vectensis (Starlet sea anemone) ARP56462_P050 Q5XH87_XENTR (Prosome macropain) subunit beta type 2) (Silurana tropicalis) 199 84.00% ORF Names:LELG_05259 EMBL EDK47078.1OrganismLodderomyces elongisporus (Yeast) (Saccharomyces Xenopus tropicalis (Western clawed frog) elongisporus) ARP41232_P050 B5DEC9_XENTR Putative uncharacterized protein (Silurana tropicalis) 970 85.00% TMCC2 ARP44707_P050 Q6NRH6_XENLA MGC83809 protein Xenopus laevis (African clawed frog) 509 100.00% Transmembrane and coiled‐coil domain family Xenopus tropicalis (Western clawed frog) TMCC2 ARP44707_P050 Q0IHU7_XENTR 2 (Silurana tropicalis) 725 100.00% Xenopus tropicalis (Western clawed frog) TMCC2 ARP44707_P050 Q0VA50_XENTR Putative uncharacterized protein MGC145249 (Silurana tropicalis) 473 78.00% Xenopus tropicalis (Western clawed frog) Ikzf1 ARP32758_P050 Q5FWQ9_XENTR IKAROS family zinc finger 1 (Ikaros) (Silurana tropicalis) 483 83.00% Ganglioside‐induced differentiation‐ Xenopus tropicalis (Western clawed frog) Gdap1l1 ARP49791_P050 Q0VFG7_XENTR associated protein 1‐like 1 (Silurana tropicalis) 364 78.00%

ORF Names:37779OrganismMonosiga brevicollis (Choanoflagellate) ARP40466_P050 Q9PW90_XENLA CRM1/XPO1 protein Xenopus laevis (African clawed frog) 1071 78.00%

ORF Names:37779OrganismMonosiga brevicollis (Choanoflagellate) ARP40466_P050 Q6NS03_XENLA Xpo1 protein Xenopus laevis (African clawed frog) 1071 78.00% Xenopus tropicalis (Western clawed frog) ARP42237_T100 Q6P314_XENTR Isocitrate dehydrogenase 3 (NAD+) alpha (Silurana tropicalis) 366 92.00% ARP42237_T100 Q6GN63_XENLA MGC82998 protein Xenopus laevis (African clawed frog) 368 92.00%

Mmp24 ARP46760_P050 Q6W5M7_XENLA Membrane‐type matrix metalloproteinase 3 Xenopus laevis (African clawed frog) 613 78.00% Mmp24 ARP46760_P050 B7ZQB2_XENLA MT3‐MMP protein Xenopus laevis (African clawed frog) 608 78.00% TRIB1 ARP52412_P050 Q6GP32_XENLA MGC80719 protein Xenopus laevis (African clawed frog) 355 100.00% ARP44684_P050 B2GTY2_XENLA LOC100158451 protein Xenopus laevis (African clawed frog) 557 92.00% BPGM ARP58217_P050 Q6GNS4_XENLA MGC80913 protein Xenopus laevis (African clawed frog) 259 83.00%

2,3‐bisphosphoglycerate mutase (Putative Xenopus tropicalis (Western clawed frog) BPGM ARP58217_P050 Q28I68_XENTR uncharacterized protein LOC549353) (Silurana tropicalis) 259 83.00% BPGM ARP58217_P050 Q6GPF4_XENLA MGC80400 protein Xenopus laevis (African clawed frog) 259 81.00% ARP40222_T100 Q8AVI3_XENLA Arbp‐prov protein Xenopus laevis (African clawed frog) 315 85.00% Xenopus tropicalis (Western clawed frog) ARP40222_T100 Q6P8D0_XENTR Acidic ribosomal phosphoprotein P0 (Silurana tropicalis) 314 85.00% ARP40222_T100 Q5U599_XENLA LOC495324 protein Xenopus laevis (African clawed frog) 460 100.00%

Mediator of RNA polymerase II transcription subunit 26 (Cofactor required for Sp1 transcriptional activation subunit 7) (CRSP complex subunit 7) (Mediator complex MED26 ARP33745_P050 MED26_XENLA subunit 26) Xenopus laevis (African clawed frog) 597 100.00% tuba4a ARP40179_P050 Q6DD58_XENLA Mec‐12 protein Xenopus laevis (African clawed frog) 448 100.00% Xenopus tropicalis (Western clawed frog) tuba4a ARP40179_P050 B7ZTG2_XENTR Tubulin, alpha 4b (Silurana tropicalis) 449 100.00% Xenopus tropicalis (Western clawed frog) tuba4a ARP40179_P050 TBA_XENTR Tubulin alpha chain (Silurana tropicalis) 449 100.00% Xenopus tropicalis (Western clawed frog) tuba4a ARP40179_P050 A4IGR5_XENTR Tuba8 protein (Silurana tropicalis) 456 78.00% tuba4a ARP40179_P050 A1L2T2_XENLA LOC100036943 protein Xenopus laevis (African clawed frog) 456 85.00% Novel protein similar to tubulin, alpha 1 Xenopus tropicalis (Western clawed frog) tuba4a ARP40179_P050 Q28CH9_XENTR (Tuba1) (Silurana tropicalis) 414 78.00% Novel protein similar to tubulin, alpha 1 Xenopus tropicalis (Western clawed frog) tuba4a ARP40179_P050 Q28C42_XENTR (Tuba1) (Silurana tropicalis) 449 78.00% Novel protein similar to tubulin, alpha 1 Xenopus tropicalis (Western clawed frog) tuba4a ARP40179_P050 A4IGU4_XENTR (Tuba1) (Silurana tropicalis) 449 78.00% ORF Names:GSPATT00004652001 EMBL CAK58280.1OrganismParamecium tetraurelia ARP32349_P050 Q6GR29_XENLA Ruvbl1 protein Xenopus laevis (African clawed frog) 456 100.00% ORF Names:GSPATT00004652001 EMBL CAK58280.1OrganismParamecium Xenopus tropicalis (Western clawed frog) tetraurelia ARP32349_P050 Q28FH8_XENTR RuvB‐like 1 (Fragment) (Silurana tropicalis) 36 100.00% ORF Names:GSPATT00004652001 EMBL CAK58280.1OrganismParamecium tetraurelia ARP32349_P050 RUVB1_XENLA RuvB‐like 1 (EC 3.6.4.12) (Pontin) Xenopus laevis (African clawed frog) 456 100.00% Xenopus tropicalis (Western clawed frog) dpcd ARP55256_P050 DPCD_XENTR Protein DPCD (Silurana tropicalis) 203 78.00% Mta2 ARP35742_P050 Q9PUN0_XENLA Metastasis associated 1‐like protein Xenopus laevis (African clawed frog) 670 76.00% Mta2 ARP35742_P050 Q4V7T0_XENLA Mta2 protein Xenopus laevis (African clawed frog) 669 76.00% ORF Names:SELSPUOL_02115 EMBL EEX76588.1OrganismSelenomonas sputigena ATCC 35185 ARP34162_P050 Q8AXN2_XENLA ‐associated zinc finger protein Xenopus laevis (African clawed frog) 375 100.00% Notch‐regulated ‐containing Xenopus tropicalis (Western clawed frog) nrarp ARP56166_P050 NRARP_XENTR protein (Silurana tropicalis) 114 100.00% Notch‐regulated ankyrin repeat‐containing nrarp ARP56166_P050 NRARP_XENLA protein Xenopus laevis (African clawed frog) 114 100.00% ORF Names:PANDA_013419 EMBL EFB21423.1OrganismAiluropoda melanoleuca (Giant panda) ARP32274_P050 Q6DF95_XENLA MGC83919 protein Xenopus laevis (African clawed frog) 604 78.00% ORF Names:PANDA_013419 EMBL EFB21423.1OrganismAiluropoda Novel zinc finger protein (Putative Xenopus tropicalis (Western clawed frog) melanoleuca (Giant panda) ARP32274_P050 Q28IN1_XENTR uncharacterized protein LOC549978) (Silurana tropicalis) 613 78.00% ORF Names:MED121_05003 EMBL EAQ64450.1OrganismMarinomonas sp. Monocarboxylate transporter 12 (MCT 12) Xenopus tropicalis (Western clawed frog) MED121 ARP44186_P050 MOT12_XENTR (Solute carrier family 16 member 12) (Silurana tropicalis) 473 78.00% ORF Names:MED121_05003 EMBL EAQ64450.1OrganismMarinomonas sp. Monocarboxylate transporter 12 (MCT 12) MED121 ARP44186_P050 MOT12_XENLA (Solute carrier family 16 member 12) Xenopus laevis (African clawed frog) 460 78.00% DNA replication licensing factor mcm7 (CDC47 homolog) (Minichromosome maintenance Xenopus tropicalis (Western clawed frog) Mcm7 ARP36653_T100 MCM7_XENTR protein 7) (Silurana tropicalis) 720 85.00% DNA replication licensing factor mcm7‐A (CDC47 homolog A) (CDC47p) (Minichromosome maintenance protein 7‐A) Mcm7 ARP36653_T100 MCM7A_XENLA (xMCM7‐A) (p90) Xenopus laevis (African clawed frog) 720 78.00% DNA replication licensing factor mcm7‐B (CDC47 homolog B) (CDC47‐2p) (Minichromosome maintenance protein 7‐B) Mcm7 ARP36653_T100 MCM7B_XENLA (xMCM7‐B) Xenopus laevis (African clawed frog) 720 78.00% HNRNPD ARP40239_T100 Q645K2_XENLA P37 AUF1 Xenopus laevis (African clawed frog) 295 85.00% Xenopus tropicalis (Western clawed frog) HNRNPD ARP40239_T100 Q537I0_XENTR AUF1 (Silurana tropicalis) 295 85.00% HNRNPD ARP40239_T100 Q4V7K8_XENLA LOC496375 protein Xenopus laevis (African clawed frog) 286 85.00% Xenopus tropicalis (Western clawed frog) ARP39508_T100 B7ZT57_XENTR Forkhead box A2 (Silurana tropicalis) 434 78.00% Forkhead box protein A2‐A (FoxA2‐A) (FoxA2a) (Fork head domain‐related protein 3) (xFD‐3) (Hepatocyte nuclear factor 3‐beta homolog A) (HNF‐3‐beta‐A) (HNF3‐beta homolog A) (HNF3‐beta‐A) (xHNF3‐beta‐A) ARP39508_T100 FXA2A_XENLA (xbeta‐1) Xenopus laevis (African clawed frog) 434 78.00% Xenopus tropicalis (Western clawed frog) ARP39508_T100 FOXA2_XENTR Forkhead box protein A2 (FoxA2) (Silurana tropicalis) 434 78.00%

Forkhead box protein A2‐B (FoxA2‐B) (FoxA2b) (Fork head domain‐related protein 3') (xFD‐3') (Hepatocyte nuclear factor 3‐beta homolog B) (HNF‐3‐beta‐B) (HNF3‐beta ARP39508_T100 FXA2B_XENLA homolog B) (HNF3‐beta‐B) (xHNF3‐beta‐B) Xenopus laevis (African clawed frog) 433 78.00% ARP39508_T100 A1A5K1_XENLA LOC100125667 protein Xenopus laevis (African clawed frog) 200 75.00%

Forkhead box protein A1‐B (FoxA1b) (Fork head domain‐related protein 7') (xFD‐7') (Forkhead protein 2) (FKH‐2) (xFKH2) (Hepatocyte nuclear factor 3‐alpha homolog ARP39508_T100 FXA1B_XENLA B) (HNF3alpha homolog B) (xHNF3alpha‐B) Xenopus laevis (African clawed frog) 427 75.00%

Forkhead box protein A1‐A (FoxA1a) (Fork head domain‐related protein 7) (xFD‐7) (Hepatocyte nuclear factor 3‐alpha homolog ARP39508_T100 FXA1A_XENLA A) (HNF3alpha homolog A) (xHNF3alpha‐A) Xenopus laevis (African clawed frog) 429 75.00% Xenopus tropicalis (Western clawed frog) ARP39508_T100 FOXA1_XENTR Forkhead box protein A1 (FoxA1) (tFoxA1) (Silurana tropicalis) 428 75.00% Xenopus tropicalis (Western clawed frog) RPA2 ARP54942_P050 Q6DFS2_XENTR Replication protein A2, 32kDa (Silurana tropicalis) 275 78.00% ARP40616_P050 Q6GPA9_XENLA MGC80562 protein Xenopus laevis (African clawed frog) 802 100.00% Xenopus tropicalis (Western clawed frog) ARP40616_P050 B1H374_XENTR LOC100145564 protein (Fragment) (Silurana tropicalis) 255 100.00% Probable 39S ribosomal protein L24, RM24 ARP41010_P050 RM24_XENLA mitochondrial (L24mt) (MRP‐L24) Xenopus laevis (African clawed frog) 216 92.00% rad54b ARP36407_P050 Q6INQ9_XENLA MGC81308 protein Xenopus laevis (African clawed frog) 895 78.00% Xenopus tropicalis (Western clawed frog) rad54b ARP36407_P050 B2GUN3_XENTR Rad54b protein (Silurana tropicalis) 897 78.00% ORF Names:GSPATT00020067001 EMBL CAK86386.1OrganismParamecium Xenopus tropicalis (Western clawed frog) tetraurelia ARP33345_P050 Q0IJ11_XENTR Putative uncharacterized protein MGC145349 (Silurana tropicalis) 506 100.00% ORF Names:GSPATT00020067001 EMBL CAK86386.1OrganismParamecium Xenopus tropicalis (Western clawed frog) tetraurelia ARP33345_P050 B1H0Y6_XENTR MGC145349 protein (Silurana tropicalis) 505 92.00%

ORF Names:v1g195005OrganismNematostel Proteasome (Prosome, macropain) 26S Xenopus tropicalis (Western clawed frog) la vectensis (Starlet sea anemone) ARP32400_P050 Q6P2Y7_XENTR subunit, non‐ATPase, 6 (Silurana tropicalis) 389 100.00%

ORF Names:v1g195005OrganismNematostel la vectensis (Starlet sea anemone) ARP32400_P050 Q5XGT1_XENLA LOC495148 protein Xenopus laevis (African clawed frog) 389 100.00%

ORF Names:v1g195005OrganismNematostel la vectensis (Starlet sea anemone) ARP32400_P050 Q7ZYE1_XENLA p44s10‐prov protein Xenopus laevis (African clawed frog) 389 85.00% LOC100037230 AVARP13076_P050 A2VDE0_XENLA LOC100037230 protein (Fragment) Xenopus laevis (African clawed frog) 205 100.00% Xenopus tropicalis (Western clawed frog) Dhx35 ARP36485_P050 Q0P4P9_XENTR DEAH (Asp‐Glu‐Ala‐His) box polypeptide 35 (Silurana tropicalis) 701 76.00% Gins1 ARP46298_T100 Q7ZT47_XENLA MGC80254 protein (Psf1) Xenopus laevis (African clawed frog) 196 85.00% Xenopus tropicalis (Western clawed frog) Gins1 ARP46298_T100 B5DES7_XENTR DNA replication complex GINS protein PSF1 (Silurana tropicalis) 196 85.00% Carbamoyl‐phosphate synthetase I (EC ARP45689_T100 Q3S2E9_XENLA 6.3.4.16) Xenopus laevis (African clawed frog) 1494 78.00% ZNF143 ARP38325_T100 Q6GPP5_XENLA MGC82721 protein Xenopus laevis (African clawed frog) 519 85.00% ZNF143 ARP38325_T100 ZN143_XENLA Isoform 2 Xenopus laevis (African clawed frog) 519 85.00% Zinc finger protein 143 (Selenocysteine tRNA Xenopus tropicalis (Western clawed frog) ZNF143 ARP38325_T100 ZN143_XENTR gene transcription‐activating factor) (Silurana tropicalis) 567 85.00%

Zinc finger protein 143 (Selenocysteine tRNA ZNF143 ARP38325_T100 ZN143_XENLA gene transcription‐activating factor) Xenopus laevis (African clawed frog) 565 85.00% Kiaa1324 ARP49563_P050 E3WE02_XENLA Estrogen‐induced gene 121‐like protein Xenopus laevis (African clawed frog) 995 90.00% UPF0577 protein KIAA1324‐like homolog (Estrogen‐induced gene 121‐like protein) Kiaa1324 ARP49563_P050 K132L_XENLA (xEIG121L) Xenopus laevis (African clawed frog) 819 90.00% AVARP00017_P050 Q6GN53_XENLA MGC83023 protein Xenopus laevis (African clawed frog) 191 100.00% AVARP00017_P050 B7ZQW0_XENLA Achaete‐scute complex‐like 1 Xenopus laevis (African clawed frog) 199 100.00% AVARP00017_P050 ASCL1_XENLA Achaete‐scute homolog 1 Xenopus laevis (African clawed frog) 199 100.00% KH domain RNA‐binding protein Sam68 KHDRBS1 ARP40666_P050 Q7SYH0_XENLA (Fragment) Xenopus laevis (African clawed frog) 75 92.00% Xenopus tropicalis (Western clawed frog) KHDRBS1 ARP40666_P050 Q28FP2_XENTR Poly(RC) binding protein 2 (Silurana tropicalis) 335 92.00% glyA ARP46128_T100 Q6AXB3_XENLA MGC79128 protein Xenopus laevis (African clawed frog) 496 100.00% Xenopus tropicalis (Western clawed frog) glyA ARP46128_T100 Q68EQ3_XENTR Shmt2 protein (Silurana tropicalis) 496 100.00% ORF Names:PACG_04082 EMBL EAZ55412.1OrganismPseudomonas Xenopus tropicalis (Western clawed frog) aeruginosa C3719 ARP54358_P050 Q6P2W4_XENTR Guk1‐prov protein (Fragment) (Silurana tropicalis) 218 84.00% ORF Names:PACG_04082 EMBL EAZ55412.1OrganismPseudomonas aeruginosa C3719 ARP54358_P050 Q6AZP9_XENLA MGC82526 protein Xenopus laevis (African clawed frog) 198 84.00% ORF Names:PACG_04082 EMBL EAZ55412.1OrganismPseudomonas aeruginosa C3719 ARP54358_P050 Q6AZF5_XENLA Guk1‐prov protein Xenopus laevis (African clawed frog) 198 84.00% ORF Names:PACG_04082 EMBL EAZ55412.1OrganismPseudomonas Xenopus tropicalis (Western clawed frog) aeruginosa C3719 ARP54358_P050 Q28EB2_XENTR Novel protein similar to guanylate kinase 1 (Silurana tropicalis) 213 84.00% ARP45694_T100 Q6GMC2_XENLA MGC81887 protein Xenopus laevis (African clawed frog) 664 85.00% ARP45694_T100 Q0VGW8_XENLA LOC100125662 protein Xenopus laevis (African clawed frog) 664 85.00% 2‐acylglycerol O‐acyltransferase 1 (EC 2.3.1.22) (Acyl‐CoA:monoacylglycerol acyltransferase 1) (MGAT1) (Monoacylglycerol Xenopus tropicalis (Western clawed frog) MOGAT1 ARP50240_P050 MOGT1_XENTR O‐acyltransferase 1) (Silurana tropicalis) 335 78.00% 2‐acylglycerol O‐acyltransferase 1 (EC 2.3.1.22) (Acyl‐CoA:monoacylglycerol acyltransferase 1) (MGAT1) (Monoacylglycerol MOGAT1 ARP50240_P050 MOGT1_XENLA O‐acyltransferase 1) Xenopus laevis (African clawed frog) 335 78.00% ARP39271_P050 Q9W7H8_XENLA Homeobox protein SIX2 (Fragment) Xenopus laevis (African clawed frog) 168 100.00% Xenopus tropicalis (Western clawed frog) ARP39271_P050 A4IHH9_XENTR Six2 protein (Silurana tropicalis) 289 100.00% ARP39271_P050 Q9W7H9_XENLA Homeobox protein SIX1 (Fragment) Xenopus laevis (African clawed frog) 165 92.00% ARP39271_P050 Q9I8H0_XENLA Homeobox protein SIX1 Xenopus laevis (African clawed frog) 284 92.00% ARP39271_P050 Q2TAS7_XENLA MGC130961 protein Xenopus laevis (African clawed frog) 276 92.00% Xenopus tropicalis (Western clawed frog) ARP39271_P050 A4IHN6_XENTR Six1 protein (Silurana tropicalis) 284 92.00% Xenopus tropicalis (Western clawed frog) Lmf2 ARP50169_P050 LMF2_XENTR Lipase maturation factor 2 (Silurana tropicalis) 707 90.00% Lmf2 ARP50169_P050 LMF2_XENLA Lipase maturation factor 2 Xenopus laevis (African clawed frog) 707 90.00% Uncharacterized glycosyltransferase AER61 Xenopus tropicalis (Western clawed frog) AER61 ARP49111_P050 AER61_XENTR (EC 2.4.‐.‐) (Silurana tropicalis) 525 92.00% Uncharacterized glycosyltransferase AER61 AER61 ARP49111_P050 AER61_XENLA (EC 2.4.‐.‐) Xenopus laevis (African clawed frog) 525 92.00%

ORF Names:zgc:162298 ZFIN ZDB‐GENE‐ 070410‐63OrganismDanio rerio Xenopus tropicalis (Western clawed frog) (Zebrafish) (Brachydanio rerio) ARP39386_P050 A4IIP6_XENTR LOC100125035 protein (Silurana tropicalis) 719 85.00% Xenopus tropicalis (Western clawed frog) tcf25 ARP47623_P050 Q0VA28_XENTR Transcription factor 25 (Basic helix‐loop‐helix) (Silurana tropicalis) 678 78.00% tcf25 ARP47623_P050 A3KMT4_XENLA LOC100049094 protein Xenopus laevis (African clawed frog) 675 78.00% Sf3b1 ARP40248_T100 Q7ZYA4_XENLA Sf3b1 protein (Fragment) Xenopus laevis (African clawed frog) 500 85.00% Sf3b1 ARP40248_T100 Q4QR12_XENLA Sf3b1 protein Xenopus laevis (African clawed frog) 814 85.00% Xenopus tropicalis (Western clawed frog) Sf3b1 ARP40248_T100 A7MC63_XENTR LOC100127558 protein (Fragment) (Silurana tropicalis) 496 85.00%

Splicing factor 3B subunit 1 (146 kDa nuclear protein) (Pre‐mRNA‐splicing factor SF3b 155 kDa subunit) (SF3b155) (Spliceosome‐ Sf3b1 ARP40248_T100 SF3B1_XENLA associated protein 155) (SAP 155) Xenopus laevis (African clawed frog) 1307 85.00% Myst2 ARP38897_P050 Q6PCK3_XENLA MGC68869 protein Xenopus laevis (African clawed frog) 535 92.00% Myst2 ARP38897_P050 Q6GPW8_XENLA MGC68869 protein Xenopus laevis (African clawed frog) 617 92.00% Myst2 ARP38897_P050 Q6AZV6_XENLA Myst2 protein Xenopus laevis (African clawed frog) 553 92.00% Xenopus tropicalis (Western clawed frog) Myst2 ARP38897_P050 Q28CF9_XENTR Myst histone acetyltransferase 2 (Silurana tropicalis) 535 92.00% Xenopus tropicalis (Western clawed frog) Myst2 ARP38897_P050 A4IGQ4_XENTR Myst2 protein (Silurana tropicalis) 558 92.00% GARS ARP58758_P050 Q6DEA1_XENLA Gars‐prov protein Xenopus laevis (African clawed frog) 747 85.00% Xenopus tropicalis (Western clawed frog) GARS ARP58758_P050 Q68FB4_XENTR Glycyl‐tRNA synthetase (Silurana tropicalis) 745 85.00% GARS ARP58758_P050 Q2NLB1_XENLA MGC130901 protein Xenopus laevis (African clawed frog) 740 85.00% ORF Names:OsI_06649 EMBL Ubiquitin‐conjugating enzyme E2D 2 (UBC4/5 EAY85278.1OrganismOryza sativa homolog, yeast) (Ubiquitin‐conjugating Xenopus tropicalis (Western clawed frog) subsp. indica (Rice) ARP43008_T100 Q28EY6_XENTR enzyme E2D 3 (UBC4/5 homolog)) (Silurana tropicalis) 147 100.00% Ubiquitin‐conjugating enzyme E2 D2 (EC ORF Names:OsI_06649 EMBL 6.3.2.19) (Ubiquitin carrier protein 4) (xUBC4) EAY85278.1OrganismOryza sativa (Ubiquitin carrier protein D2) (Ubiquitin‐ subsp. indica (Rice) ARP43008_T100 UB2D2_XENLA protein ligase D2) Xenopus laevis (African clawed frog) 147 100.00% ORF Names:OsI_06649 EMBL Ubiquitin‐conjugating enzyme E2 D4 (EC EAY85278.1OrganismOryza sativa 6.3.2.19) (Ubiquitin carrier protein D4) subsp. indica (Rice) ARP43008_T100 UB2D4_XENLA (Ubiquitin‐protein ligase D4) Xenopus laevis (African clawed frog) 147 78.00% smarcd1 ARP33310_P050 Q66IP7_XENLA MGC86299 protein Xenopus laevis (African clawed frog) 465 84.00% SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily Xenopus tropicalis (Western clawed frog) smarcd1 ARP33310_P050 Q28BL9_XENTR d, member 2 (Silurana tropicalis) 480 84.00% smarcd1 ARP33310_P050 Q7ZXG1_XENLA Smarcd1 protein (Fragment) Xenopus laevis (African clawed frog) 481 84.00% SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily Xenopus tropicalis (Western clawed frog) smarcd1 ARP33310_P050 Q6GL18_XENTR d, member 1 (Silurana tropicalis) 508 84.00% smarcd1 ARP33310_P050 Q6DCP7_XENLA Smarcd1 protein (Fragment) Xenopus laevis (African clawed frog) 513 84.00% smarcd1 ARP33310_P050 Q66J25_XENLA Smarcd1 protein (Fragment) Xenopus laevis (African clawed frog) 504 84.00% smarcd1 ARP33310_P050 Q505N3_XENLA Smarcd1 protein (Fragment) Xenopus laevis (African clawed frog) 496 84.00% SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily Xenopus tropicalis (Western clawed frog) smarcd1 ARP33310_P050 Q28CT6_XENTR d, member 1 (Silurana tropicalis) 508 84.00% smarcd1 ARP33310_P050 A1A5J8_XENLA Smarcd1 protein Xenopus laevis (African clawed frog) 507 84.00% ARP35460_P050 Q6NTX7_XENLA Kcnab2 protein Xenopus laevis (African clawed frog) 353 92.00%

Voltage‐gated potassium channel subunit beta‐ ARP35460_P050 KCAB2_XENLA 2 (K(+) channel subunit beta‐2) (Kv‐beta‐2) Xenopus laevis (African clawed frog) 367 92.00%

Potassium voltage‐gated channel, shaker‐ Xenopus tropicalis (Western clawed frog) ARP35460_P050 Q28EG4_XENTR related subfamily, beta member 1 (Silurana tropicalis) 400 85.00% Xenopus tropicalis (Western clawed frog) FOSB ARP31378_P050 A4IGZ5_XENTR LOC100038288 protein (Fragment) (Silurana tropicalis) 306 76.00% AVARP00009_P050 P70071_XENLA NM23/nucleoside diphosphate kinase Xenopus laevis (African clawed frog) 154 92.00%

Nucleoside diphosphate kinase A2 (NDK A2) (NDP kinase A2) (EC 2.7.4.6) AVARP00009_P050 NDKA2_XENLA (NM23/nucleoside diphosphate kinase A2) Xenopus laevis (African clawed frog) 154 92.00% Nucleoside diphosphate kinase A1 (NDK A1) (NDP kinase A1) (EC 2.7.4.6) AVARP00009_P050 NDKA1_XENLA (NM23/nucleoside diphosphate kinase A1) Xenopus laevis (African clawed frog) 154 92.00% Non‐metastatic cells 1, protein (NM23A) expressed in (Non‐metastatic cells 2, protein Xenopus tropicalis (Western clawed frog) AVARP00009_P050 Q6AZK9_XENTR (NM23B) expressed in) (Silurana tropicalis) 154 100.00% AVARP00009_P050 Q66KP0_XENLA MGC85572 protein Xenopus laevis (African clawed frog) 169 84.00% AVARP00009_P050 Q6NUB6_XENLA MGC81083 protein Xenopus laevis (African clawed frog) 183 84.00% AVARP00009_P050 Q5PQ84_XENLA LOC495951 protein Xenopus laevis (African clawed frog) 180 84.00% LOC734101 protein (Non‐metastatic cells 4, Xenopus tropicalis (Western clawed frog) AVARP00009_P050 Q28BM9_XENTR protein expressed in) (Silurana tropicalis) 186 84.00% Xenopus tropicalis (Western clawed frog) AVARP00009_P050 A9UMB8_XENTR LOC100135302 protein (Silurana tropicalis) 169 76.00% MGC89980 protein (Non‐metastatic cells 3, Xenopus tropicalis (Western clawed frog) AVARP00009_P050 Q6DEP3_XENTR protein expressed in) (Silurana tropicalis) 169 76.00% ORF Names:GSPATT00037602001 EMBL CAK69165.1OrganismParamecium SAM domain and HD domain‐containing tetraurelia ARP55262_P050 SAMH1_XENLA protein 1 (EC 3.1.4.‐) Xenopus laevis (African clawed frog) 632 92.00% Sp‐Smad2/3 ARP38694_T100 Q91912_XENLA Mad2 protein Xenopus laevis (African clawed frog) 467 100.00% Sp‐Smad2/3 ARP38694_T100 Q6IRR4_XENLA MGC81131 protein Xenopus laevis (African clawed frog) 467 100.00% Xenopus tropicalis (Western clawed frog) Sp‐Smad2/3 ARP38694_T100 Q5U4Q3_XENTR SMAD family member 2 (Silurana tropicalis) 467 100.00% Sp‐Smad2/3 ARP38694_T100 Q32N71_XENLA Mad2 protein Xenopus laevis (African clawed frog) 467 100.00% Xenopus tropicalis (Western clawed frog) Sp‐Smad2/3 ARP38694_T100 Q07G47_XENTR OTTXETP00000005021 (Silurana tropicalis) 437 100.00% MAD, mothers against decapentaplegic Sp‐Smad2/3 ARP38694_T100 Q90YE5_XENLA homolog 3 (SMAD3) Xenopus laevis (African clawed frog) 425 100.00% Xenopus tropicalis (Western clawed frog) Sp‐Smad2/3 ARP38694_T100 Q68EP5_XENTR SMAD family member 3 (Silurana tropicalis) 425 100.00% Sp‐Smad2/3 ARP38694_T100 Q98TU1_XENLA Smad protein Xenopus laevis (African clawed frog) 466 92.00% Sp‐Smad2/3 ARP38694_T100 Q8QGG6_XENLA Smad8A Xenopus laevis (African clawed frog) 466 92.00% Sp‐Smad2/3 ARP38694_T100 Q8QGG5_XENLA Smad8B Xenopus laevis (African clawed frog) 468 92.00% Sp‐Smad2/3 ARP38694_T100 Q8QGG4_XENLA Smad8C Xenopus laevis (African clawed frog) 466 92.00% Sp‐Smad2/3 ARP38694_T100 Q6PF37_XENLA MGC69016 protein Xenopus laevis (African clawed frog) 465 92.00% Xenopus tropicalis (Western clawed frog) Sp‐Smad2/3 ARP38694_T100 Q6DIZ6_XENTR SMAD family member 9 (Silurana tropicalis) 466 92.00% Sp‐Smad2/3 ARP38694_T100 Q91913_XENLA Mad1 protein Xenopus laevis (African clawed frog) 464 84.00% Sp‐Smad2/3 ARP38694_T100 Q6PF32_XENLA Xmad protein Xenopus laevis (African clawed frog) 464 84.00% Xenopus tropicalis (Western clawed frog) Sp‐Smad2/3 ARP38694_T100 Q6DIS7_XENTR SMAD family member 1 (Silurana tropicalis) 464 84.00% Sp‐Smad2/3 ARP38694_T100 Q5HZ76_XENLA MADH1 protein Xenopus laevis (African clawed frog) 464 84.00% Sp‐Smad2/3 ARP38694_T100 P79947_XENLA Smad1.1 Xenopus laevis (African clawed frog) 467 84.00% ORF Names:GSPATT00030566001 EMBL CAK59929.1OrganismParamecium tetraurelia ARP52514_P050 Q5M781_XENLA Dynein light chain dlc8b (Dynll2 protein) Xenopus laevis (African clawed frog) 89 100.00% ORF Names:GSPATT00030566001 EMBL CAK59929.1OrganismParamecium Xenopus tropicalis (Western clawed frog) tetraurelia ARP52514_P050 B0BM87_XENTR Dynll2 protein (Silurana tropicalis) 89 100.00% ORF Names:GSPATT00030566001 EMBL CAK59929.1OrganismParamecium tetraurelia ARP52514_P050 Q6NTS8_XENLA MGC68763 protein Xenopus laevis (African clawed frog) 89 92.00% ORF Names:GSPATT00030566001 EMBL CAK59929.1OrganismParamecium tetraurelia ARP52514_P050 Q6GPR8_XENLA Dynein light chain dlc8a (MGC82658 protein) Xenopus laevis (African clawed frog) 89 92.00% ORF Names:GSPATT00030566001 EMBL CAK59929.1OrganismParamecium Dynein light chain 2 (Dynein, light chain, LC8‐ Xenopus tropicalis (Western clawed frog) tetraurelia ARP52514_P050 Q6DEU5_XENTR type 1) (Silurana tropicalis) 89 92.00% ORF Names:GSPATT00004682001 EMBL CAK58310.1OrganismParamecium U1 small nuclear ribonucleoprotein 70 kDa Xenopus tropicalis (Western clawed frog) tetraurelia ARP51249_P050 RU17_XENTR (U1 snRNP 70 kDa) (U1‐70K) (snRNP70) (Silurana tropicalis) 471 78.00% ORF Names:GSPATT00004682001 EMBL CAK58310.1OrganismParamecium Transcription initiation factor TFIID subunit 3 tetraurelia ARP51249_P050 TAF3_XENLA (TBP‐associated factor 3) Xenopus laevis (African clawed frog) 845 80.00% FUND1 ARP53281_P050 Q6DFJ3_XENLA MGC82241 protein Xenopus laevis (African clawed frog) 188 92.00% Xenopus tropicalis (Western clawed frog) FUND1 ARP53281_P050 B1H3B1_XENTR LOC100145592 protein (Silurana tropicalis) 151 92.00% FUND1 ARP53281_P050 FUND1_XENLA FUN14 domain‐containing protein 1 Xenopus laevis (African clawed frog) 151 84.00% Xenopus tropicalis (Western clawed frog) fip1l1 ARP41031_P050 B2GU24_XENTR LOC100158492 protein (Silurana tropicalis) 570 85.00% Xenopus tropicalis (Western clawed frog) fip1l1 ARP41031_P050 Q28FS8_XENTR FIP1 like 1 (S. cerevisiae) (Fragment) (Silurana tropicalis) 288 80.00% Xenopus tropicalis (Western clawed frog) fip1l1 ARP41031_P050 A4QNK8_XENTR LOC733481 protein (Silurana tropicalis) 580 80.00% fip1l1 ARP41031_P050 Q63ZL7_XENLA LOC494780 protein (Fragment) Xenopus laevis (African clawed frog) 586 80.00% fip1l1 ARP41031_P050 A0AUS9_XENLA LOC494780 protein Xenopus laevis (African clawed frog) 583 80.00% Xenopus tropicalis (Western clawed frog) fip1l1 ARP41031_P050 Q28IP4_XENTR FIP1 like 1 (S. cerevisiae) (Silurana tropicalis) 577 84.00% Xenopus tropicalis (Western clawed frog) ARP32676_P050 Q6PBG0_XENTR Putative uncharacterized protein MGC75686 (Silurana tropicalis) 180 85.00% ARP32676_P050 Q3KQD2_XENLA Putative uncharacterized protein Xenopus laevis (African clawed frog) 180 85.00% ARP41769_P050 Q90WM9_XENLA Glutathione S‐transferase (EC 2.5.1.18) Xenopus laevis (African clawed frog) 219 92.00% ARP41769_P050 Q7SZ23_XENLA Gstm2‐prov protein Xenopus laevis (African clawed frog) 219 92.00% Glutathione S‐transferase M1 (MGC89299 Xenopus tropicalis (Western clawed frog) ARP41769_P050 Q6DIR0_XENTR protein) (Silurana tropicalis) 216 92.00% Xenopus tropicalis (Western clawed frog) ARP41769_P050 Q28G37_XENTR Glutathione S‐transferase M1 (Silurana tropicalis) 216 92.00% CYP1A1 ARP41404_P050 Q9YI89_XENLA Cytochrome P450 Xenopus laevis (African clawed frog) 526 78.00%

CYP1A1 ARP41404_P050 Q9YI88_XENLA Cytochrome P450 (LOC100036775 protein) Xenopus laevis (African clawed frog) 526 78.00% CYP1A1 ARP41404_P050 Q4FZM4_XENLA LOC100036775 protein (Fragment) Xenopus laevis (African clawed frog) 448 78.00% Xenopus tropicalis (Western clawed frog) CYP1A1 ARP41404_P050 A4IGV4_XENTR LOC100037911 protein (Silurana tropicalis) 525 78.00% Xenopus tropicalis (Western clawed frog) GTPBP2 ARP42539_T100 A0JLZ2_XENTR GTP binding protein 2 (Silurana tropicalis) 584 78.00% GTPBP2 ARP42539_T100 A6H8J2_XENLA LOC100101330 protein Xenopus laevis (African clawed frog) 584 83.00% ORF Names:CpipJ_CPIJ003165 EMBL EDS38213.1OrganismCulex quinquefasciatus (Southern house mosquito) (Culex pungens) ARP46143_T100 Q640F3_XENLA Psme3b protein Xenopus laevis (African clawed frog) 254 100.00% ORF Names:CpipJ_CPIJ003165 EMBL EDS38213.1OrganismCulex quinquefasciatus (Southern house Xenopus tropicalis (Western clawed frog) mosquito) (Culex pungens) ARP46143_T100 A4II64_XENTR Psme3 protein (Silurana tropicalis) 254 100.00% ORF Names:CpipJ_CPIJ003165 EMBL EDS38213.1OrganismCulex quinquefasciatus (Southern house mosquito) (Culex pungens) ARP46143_T100 Q6NTV2_XENLA Psme3 protein Xenopus laevis (African clawed frog) 254 92.00% sin3b ARP50590_P050 A1L1H5_XENLA LOC100036844 protein Xenopus laevis (African clawed frog) 1125 92.00% Xenopus tropicalis (Western clawed frog) sin3b ARP50590_P050 Q0VA09_XENTR SIN3 homolog B, transcription regulator (Silurana tropicalis) 1126 84.00% Xenopus tropicalis (Western clawed frog) ARP41359_P050 Q28FC0_XENTR Elac1 (Prov) (Silurana tropicalis) 363 78.00% Glutathione S‐transferase M1 (MGC89299 Xenopus tropicalis (Western clawed frog) ARP48485_P050 Q6DIR0_XENTR protein) (Silurana tropicalis) 216 76.00% Xenopus tropicalis (Western clawed frog) ARP48485_P050 Q28G37_XENTR Glutathione S‐transferase M1 (Silurana tropicalis) 216 76.00% OLFML2A ARP53415_P050 Q7T0U7_XENLA LOC398693 protein (Fragment) Xenopus laevis (African clawed frog) 245 85.00% Xenopus tropicalis (Western clawed frog) OLFML2A ARP53415_P050 OLM2A_XENTR Olfactomedin‐like protein 2A (Silurana tropicalis) 642 85.00% fev ARP38592_P050 Q91744_XENLA XE1‐a protein (Fragment) Xenopus laevis (African clawed frog) 268 100.00% fev ARP38592_P050 Q6DJL5_XENLA C‐ets‐1b protein Xenopus laevis (African clawed frog) 439 100.00% fev ARP38592_P050 Q6DE76_XENLA LOC397877 protein Xenopus laevis (African clawed frog) 472 100.00% Xenopus tropicalis (Western clawed frog) fev ARP38592_P050 B3DM35_XENTR LOC100170599 protein (Silurana tropicalis) 438 100.00% Xenopus tropicalis (Western clawed frog) fev ARP38592_P050 B1WAP2_XENTR LOC100145687 protein (Silurana tropicalis) 471 100.00% fev ARP38592_P050 A2RV55_XENLA Ets2a‐A protein Xenopus laevis (African clawed frog) 472 100.00% fev ARP38592_P050 A1L2V8_XENLA Ets1a‐a protein Xenopus laevis (African clawed frog) 438 100.00% fev ARP38592_P050 ETS2B_XENLA Protein c‐ets‐2‐B (C‐ets‐2B) Xenopus laevis (African clawed frog) 472 100.00% fev ARP38592_P050 ETS2A_XENLA Protein c‐ets‐2‐A (C‐ets‐2A) Xenopus laevis (African clawed frog) 472 100.00% Protein c‐ets‐1‐B (C‐ets‐1B) (XE1‐B) fev ARP38592_P050 ETS1B_XENLA (Fragment) Xenopus laevis (African clawed frog) 268 100.00% fev ARP38592_P050 ETS1A_XENLA Protein c‐ets‐1‐A (C‐ets‐1A) Xenopus laevis (African clawed frog) 438 100.00% fev ARP38592_P050 Q4KLQ2_XENLA MGC115679 protein Xenopus laevis (African clawed frog) 369 92.00% Xenopus tropicalis (Western clawed frog) fev ARP38592_P050 B0JZY8_XENTR Ets1 protein (Silurana tropicalis) 243 92.00% fev ARP38592_P050 Q9W700_XENLA Erg protein Xenopus laevis (African clawed frog) 485 85.00% fev ARP38592_P050 Q9W6Z9_XENLA Erg protein Xenopus laevis (African clawed frog) 456 85.00% fev ARP38592_P050 Q7T0T1_XENLA Elk3‐prov protein Xenopus laevis (African clawed frog) 446 85.00% fev ARP38592_P050 Q6GNZ9_XENLA MGC80765 protein Xenopus laevis (African clawed frog) 485 85.00% ELK3, ETS‐domain protein (SRF accessory Xenopus tropicalis (Western clawed frog) fev ARP38592_P050 Q0IHT9_XENTR protein 2) (Silurana tropicalis) 421 85.00% fev ARP38592_P050 B7ZSD3_XENLA Erg gene (Erg_E) Xenopus laevis (African clawed frog) 456 85.00% fev ARP38592_P050 B5AIC3_XENLA Ternary complex factor Elk‐1 Xenopus laevis (African clawed frog) 411 85.00% Xenopus tropicalis (Western clawed frog) fev ARP38592_P050 B4F6M4_XENTR Putative uncharacterized protein (Silurana tropicalis) 458 85.00% Xenopus tropicalis (Western clawed frog) fev ARP38592_P050 A4IHU3_XENTR Fli1 protein (Silurana tropicalis) 459 85.00% fev ARP38592_P050 A1L2Y0_XENLA LOC100036985 protein Xenopus laevis (African clawed frog) 288 85.00% ARP54754_P050 Q501R0_XENLA Putative uncharacterized protein Xenopus laevis (African clawed frog) 194 100.00% ARP54754_P050 Q7SZA2_XENLA LOC398634 protein (Fragment) Xenopus laevis (African clawed frog) 114 85.00% Xenopus tropicalis (Western clawed frog) ARP54754_P050 H10_XENTR Histone H1.0 (Histone H1(0)) (Histone H5) (Silurana tropicalis) 196 85.00% Histone H1.0‐B (H1‐SA) (H1D) (Histone H1(0)‐ ARP54754_P050 H10B_XENLA 2) (Histone H5A) (XlH5A) Xenopus laevis (African clawed frog) 196 85.00% Histone H1.0‐A (H1‐SB) (H1E) (Histone H1(0)‐ ARP54754_P050 H10A_XENLA 1) (Histone H5B) (XlH5B) Xenopus laevis (African clawed frog) 194 85.00% dscam ARP45086_P050 Q566E9_XENLA MGC115318 protein Xenopus laevis (African clawed frog) 472 85.00% Xenopus tropicalis (Western clawed frog) dscam ARP45086_P050 B6ICZ9_XENTR Putative uncharacterized protein (Silurana tropicalis) 2008 85.00% Xenopus tropicalis (Western clawed frog) Wwp1 ARP43067_P050 Q0P4P5_XENTR Wwp1 protein (Silurana tropicalis) 914 81.00% tbc1d10a ARP34521_T100 A1L2G6_XENLA LOC733246 protein Xenopus laevis (African clawed frog) 506 92.00% tbc1d10a ARP34521_T100 Q4V841_XENLA LOC733246 protein (Fragment) Xenopus laevis (African clawed frog) 446 84.00% Xenopus tropicalis (Western clawed frog) tbc1d10a ARP34521_T100 B5DES5_XENTR LOC779497 protein (Silurana tropicalis) 506 84.00% tbc1d10a ARP34521_T100 Q5U4T0_XENLA LOC495442 protein Xenopus laevis (African clawed frog) 504 76.00% Xenopus tropicalis (Western clawed frog) itch ARP43087_P050 Q0VA08_XENTR Wwp2 protein (Silurana tropicalis) 729 100.00% Xenopus tropicalis (Western clawed frog) itch ARP43087_P050 A0JM32_XENTR Itchy E3 ubiquitin protein ligase homolog (Silurana tropicalis) 853 80.00% Ordered Locus Names:CENSYa_1346OrganismCenarch aeum symbiosum ARP46225_P050 Q6GQB6_XENLA MGC80186 protein Xenopus laevis (African clawed frog) 470 100.00% ORF Names:PGUG_04215 EMBL EDK40117.2OrganismPichia guilliermondii (Yeast) (Candida guilliermondii) ARP54366_P050 Q7ZYP7_XENLA MGC53627 protein Xenopus laevis (African clawed frog) 514 92.00% ORF Names:PGUG_04215 EMBL EDK40117.2OrganismPichia guilliermondii (Yeast) (Candida guilliermondii) ARP54366_P050 Q7ZXT8_XENLA Impdh2‐prov protein Xenopus laevis (African clawed frog) 514 92.00% ORF Names:PGUG_04215 EMBL EDK40117.2OrganismPichia guilliermondii (Yeast) (Candida guilliermondii) ARP54366_P050 Q7ZWN1_XENLA Impdh1‐prov protein Xenopus laevis (African clawed frog) 514 92.00% ORF Names:PGUG_04215 EMBL EDK40117.2OrganismPichia guilliermondii (Yeast) (Candida IMP (Inosine monophosphate) dehydrogenase Xenopus tropicalis (Western clawed frog) guilliermondii) ARP54366_P050 Q66JD5_XENTR 2 (Silurana tropicalis) 514 92.00% ORF Names:PGUG_04215 EMBL EDK40117.2OrganismPichia guilliermondii (Yeast) (Candida IMP (Inosine monophosphate) dehydrogenase Xenopus tropicalis (Western clawed frog) guilliermondii) ARP54366_P050 Q28D47_XENTR 1 (Silurana tropicalis) 514 92.00% ARP38551_P050 Q9DDU6_XENLA Single‐minded Xenopus laevis (African clawed frog) 760 100.00% ORF Names:ACLA_030400 EMBL EAW08307.1OrganismAspergillus clavatus ARP46110_T100 Q91803_XENLA Nucleolar phosphoprotein Xenopus laevis (African clawed frog) 990 92.00% ORF Names:ACLA_030400 EMBL EAW08307.1OrganismAspergillus Xenopus tropicalis (Western clawed frog) clavatus ARP46110_T100 Q6P1U1_XENTR Nolc1‐prov protein (Fragment) (Silurana tropicalis) 916 92.00% ORF Names:ACLA_030400 EMBL EAW08307.1OrganismAspergillus Novel protein containing SRP40 C‐terminal Xenopus tropicalis (Western clawed frog) clavatus ARP46110_T100 Q28EK2_XENTR domain (Silurana tropicalis) 917 92.00% ORF Names:v1g122631OrganismNematostel la vectensis (Starlet sea anemone) ARP39095_P050 Q6DCW9_XENLA MGC80612 protein Xenopus laevis (African clawed frog) 728 100.00%

ORF Names:v1g122631OrganismNematostel Xenopus tropicalis (Western clawed frog) la vectensis (Starlet sea anemone) ARP39095_P050 B2GUB5_XENTR LOC100158546 protein (Silurana tropicalis) 727 100.00%

ORF Names:AGAP001874OrganismAnophel es gambiae (African malaria mosquito) ARP56194_P050 Q6J1M1_XENLA Rap 1A GTPase (Rap1a protein) Xenopus laevis (African clawed frog) 185 100.00%

ORF Names:AGAP001874OrganismAnophel es gambiae (African malaria mosquito) ARP56194_P050 Q6J1M0_XENLA MGC80662 protein (Rap 1A2 GTPase) Xenopus laevis (African clawed frog) 185 100.00%

ORF Names:AGAP001874OrganismAnophel Xenopus tropicalis (Western clawed frog) es gambiae (African malaria mosquito) ARP56194_P050 A4II48_XENTR Rap1a protein (Silurana tropicalis) 185 100.00%

ORF Names:AGAP001874OrganismAnophel Xenopus tropicalis (Western clawed frog) es gambiae (African malaria mosquito) ARP56194_P050 RAP1B_XENTR Ras‐related protein Rap‐1b (Silurana tropicalis) 184 100.00%

ORF Names:AGAP001874OrganismAnophel es gambiae (African malaria mosquito) ARP56194_P050 RAP1B_XENLA Ras‐related protein Rap‐1b Xenopus laevis (African clawed frog) 184 100.00%

ORF Names:AGAP001874OrganismAnophel es gambiae (African malaria mosquito) ARP56194_P050 Q91832_XENLA LOC397771 protein (X.laevis ras protein) Xenopus laevis (African clawed frog) 186 100.00%

ORF Names:AGAP001874OrganismAnophel es gambiae (African malaria mosquito) ARP56194_P050 Q8UUZ4_XENLA Small G‐protein H‐Ras Xenopus laevis (African clawed frog) 189 100.00%

ORF Names:AGAP001874OrganismAnophel Kras2 protein (V‐Ki‐ras2 Kirsten rat sarcoma Xenopus tropicalis (Western clawed frog) es gambiae (African malaria mosquito) ARP56194_P050 Q66JH1_XENTR viral oncogene homolog) (Silurana tropicalis) 186 100.00% ORF Names:AGAP001874OrganismAnophel es gambiae (African malaria mosquito) ARP56194_P050 Q66JB2_XENLA Putative uncharacterized protein Xenopus laevis (African clawed frog) 187 100.00%

ORF Names:AGAP001874OrganismAnophel es gambiae (African malaria mosquito) ARP56194_P050 Q5U5E1_XENLA Putative uncharacterized protein Xenopus laevis (African clawed frog) 187 100.00%

ORF Names:AGAP001874OrganismAnophel V‐Ha‐ras Harvey rat sarcoma viral oncogene Xenopus tropicalis (Western clawed frog) es gambiae (African malaria mosquito) ARP56194_P050 Q28EW2_XENTR homolog (Silurana tropicalis) 189 100.00%

ORF Novel gene of the neuroblastoma RAS viral (V‐ Names:AGAP001874OrganismAnophel ras) oncogene homolog family (Putative Xenopus tropicalis (Western clawed frog) es gambiae (African malaria mosquito) ARP56194_P050 Q28D17_XENTR uncharacterized protein LOC549517) (Silurana tropicalis) 189 100.00%

ORF Names:AGAP001874OrganismAnophel es gambiae (African malaria mosquito) ARP56194_P050 O93563_XENLA Ras protein Xenopus laevis (African clawed frog) 188 100.00% Siah1b ARP33290_P050 B7ZS60_XENLA Seven in absentia homolog 2 Xenopus laevis (African clawed frog) 313 100.00% Xenopus tropicalis (Western clawed frog) Siah1b ARP33290_P050 A4IIN1_XENTR Siah2 protein (Silurana tropicalis) 318 100.00%

E3 ubiquitin‐protein ligase siah2 (EC 6.3.2.‐) Siah1b ARP33290_P050 SIAH2_XENLA (Seven in absentia homolog 2) (Xsiah‐2) Xenopus laevis (African clawed frog) 313 100.00% MGC79105 protein (Seven in absentia‐like Siah1b ARP33290_P050 Q6GQJ5_XENLA protein 1 isoform a) Xenopus laevis (African clawed frog) 282 92.00% Xenopus tropicalis (Western clawed frog) Siah1b ARP33290_P050 Q5FVA4_XENTR Seven in absentia homolog 1 (Silurana tropicalis) 282 92.00% CDKL2 ARP58606_P050 Q6GMD6_XENLA LOC443693 protein (Fragment) Xenopus laevis (African clawed frog) 320 100.00% ORF Names:TVAG_184190 EMBL EAY10517.1OrganismTrichomonas vaginalis ARP46172_P050 Q7ZTM5_XENLA Rfc5‐prov protein Xenopus laevis (African clawed frog) 335 92.00% ORF Names:TVAG_184190 EMBL EAY10517.1OrganismTrichomonas Replication factor C (Activator 1) 5 Xenopus tropicalis (Western clawed frog) vaginalis ARP46172_P050 Q5XGD2_XENTR (Replication factor C (Activator 1) 5, 36.5kDa) (Silurana tropicalis) 335 92.00% ORF Names:TVAG_184190 EMBL EAY10517.1OrganismTrichomonas vaginalis ARP46172_P050 Q6GQ59_XENLA MGC80325 protein Xenopus laevis (African clawed frog) 335 85.00% ARP34584_P050 Q6DKM0_XENLA MGC83065 protein Xenopus laevis (African clawed frog) 1230 92.00% h2afy ARP58284_P050 Q6GP69_XENLA MGC80637 protein Xenopus laevis (African clawed frog) 371 100.00% Xenopus tropicalis (Western clawed frog) h2afy ARP58284_P050 Q6DF50_XENTR H2A histone (Silurana tropicalis) 372 100.00% h2afy ARP58284_P050 Q7T0S0_XENLA H2afy2‐prov protein Xenopus laevis (African clawed frog) 371 92.00% h2afy ARP58284_P050 Q6PH89_XENLA MGC68595 protein Xenopus laevis (African clawed frog) 139 92.00% Xenopus tropicalis (Western clawed frog) h2afy ARP58284_P050 Q6DES9_XENTR LOC447961 protein (Fragment) (Silurana tropicalis) 248 92.00% Xenopus tropicalis (Western clawed frog) h2afy ARP58284_P050 Q5FWR2_XENTR H2afy protein (Silurana tropicalis) 369 92.00% Xenopus tropicalis (Western clawed frog) h2afy ARP58284_P050 Q28HD8_XENTR HIST1H2AH protein (Similar to histone 2a) (Silurana tropicalis) 138 92.00% Xenopus tropicalis (Western clawed frog) h2afy ARP58284_P050 A9JSN9_XENTR LOC100127770 protein (Silurana tropicalis) 138 92.00% h2afy ARP58284_P050 A1L2I5_XENLA LOC100036858 protein Xenopus laevis (African clawed frog) 369 92.00% h2afy ARP58284_P050 H2AX_XENLA Histone H2A.x (H2a/x) Xenopus laevis (African clawed frog) 139 92.00% Fth1 ARP54620_P050 Q7ZXM8_XENLA MGC64558 protein Xenopus laevis (African clawed frog) 177 85.00% Xenopus tropicalis (Western clawed frog) Fth1 ARP54620_P050 Q6DDB5_XENTR MGC89846 protein (Silurana tropicalis) 177 85.00% Ferritin heavy chain, oocyte isoform (EC Fth1 ARP54620_P050 FRIH3_XENLA 1.16.3.1) (A‐ferritin) (GV‐HCH) (XeAF) Xenopus laevis (African clawed frog) 177 85.00% Xenopus tropicalis (Western clawed frog) Fth1 ARP54620_P050 Q6P8C6_XENTR Ferritin, heavy polypeptide 1 (Silurana tropicalis) 176 78.00% Xenopus tropicalis (Western clawed frog) ACTN4 ARP42202_T100 Q6DFP7_XENTR Actinin, alpha 4 (Silurana tropicalis) 904 100.00% ACTN4 ARP42202_T100 Q6DCS8_XENLA Actn4‐prov protein Xenopus laevis (African clawed frog) 904 100.00% ACTN4 ARP42202_T100 Q32NM2_XENLA MGC131041 protein Xenopus laevis (African clawed frog) 377 100.00% ACTN4 ARP42202_T100 Q7ZY34_XENLA ACTN1 protein Xenopus laevis (African clawed frog) 890 84.00% ACTN4 ARP42202_T100 Q6NRW6_XENLA MGC81191 protein Xenopus laevis (African clawed frog) 890 84.00% Xenopus tropicalis (Western clawed frog) ACTN4 ARP42202_T100 Q05AR8_XENTR Actinin, alpha 1 (Silurana tropicalis) 885 84.00% Xenopus tropicalis (Western clawed frog) ACTN4 ARP42202_T100 B4F6H3_XENTR Putative uncharacterized protein (Silurana tropicalis) 298 84.00% Xenopus tropicalis (Western clawed frog) ARP48286_T100 Q5MAT0_XENTR Mitochondrial malate dehydrogenase 2 (Silurana tropicalis) 338 92.00% MGC79037 protein (Mitochondrial malate ARP48286_T100 Q6GR58_XENLA dehydrogenase 2b) Xenopus laevis (African clawed frog) 338 78.00% Mdh2a protein (Mitochondrial malate ARP48286_T100 Q6B4U5_XENLA dehydrogenase 2a) Xenopus laevis (African clawed frog) 338 78.00% ORF Names:CpipJ_CPIJ011014 EMBL EDS34873.1OrganismCulex quinquefasciatus (Southern house Proteasome (Prosome, macropain) 26S Xenopus tropicalis (Western clawed frog) mosquito) (Culex pungens) ARP32399_T100 Q6P2Y7_XENTR subunit, non‐ATPase, 6 (Silurana tropicalis) 389 92.00% ORF Names:CpipJ_CPIJ011014 EMBL EDS34873.1OrganismCulex quinquefasciatus (Southern house mosquito) (Culex pungens) ARP32399_T100 Q5XGT1_XENLA LOC495148 protein Xenopus laevis (African clawed frog) 389 85.00% ORF Names:CpipJ_CPIJ011014 EMBL EDS34873.1OrganismCulex quinquefasciatus (Southern house mosquito) (Culex pungens) ARP32399_T100 Q7ZYE1_XENLA p44s10‐prov protein Xenopus laevis (African clawed frog) 389 92.00% Pdk3 protein (Pyruvate dehydrogenase kinase, Xenopus tropicalis (Western clawed frog) PDK3 ARP46127_P050 A9ULF7_XENTR isozyme 3) (Silurana tropicalis) 405 100.00% Xenopus tropicalis (Western clawed frog) ARP41659_P050 Q6DF22_XENTR Aminolevulinate, delta‐, synthase 2 (Silurana tropicalis) 608 92.00% ARP41659_P050 Q68F30_XENLA MGC82115 protein Xenopus laevis (African clawed frog) 609 92.00% ARP41659_P050 Q5XG49_XENLA LOC495283 protein (Fragment) Xenopus laevis (African clawed frog) 599 92.00% ARP41659_P050 Q6PAZ6_XENLA MGC68700 protein Xenopus laevis (African clawed frog) 621 78.00%

ARP41659_P050 Q6EE56_XENLA Aminolevulinic acid synthase 1 (Fragment) Xenopus laevis (African clawed frog) 344 78.00% ARP41659_P050 Q6DKE7_XENLA MGC81838 protein Xenopus laevis (African clawed frog) 623 78.00% Xenopus tropicalis (Western clawed frog) ARP41659_P050 Q66JC7_XENTR MGC79710 protein (Silurana tropicalis) 628 78.00% Xenopus tropicalis (Western clawed frog) ARP41659_P050 Q28HS9_XENTR Aminolevulinate, delta‐, synthase 1 (Silurana tropicalis) 628 78.00% ORF Names:Smp_000650 EMBL CAZ27764.1OrganismSchistosoma MGC79105 protein (Seven in absentia‐like mansoni (Blood fluke) ARP38212_T100 Q6GQJ5_XENLA protein 1 isoform a) Xenopus laevis (African clawed frog) 282 100.00% ORF Names:Smp_000650 EMBL CAZ27764.1OrganismSchistosoma Xenopus tropicalis (Western clawed frog) mansoni (Blood fluke) ARP38212_T100 Q5FVA4_XENTR Seven in absentia homolog 1 (Silurana tropicalis) 282 100.00% ORF Names:Smp_000650 EMBL CAZ27764.1OrganismSchistosoma mansoni (Blood fluke) ARP38212_T100 B7ZS60_XENLA Seven in absentia homolog 2 Xenopus laevis (African clawed frog) 313 92.00% ORF Names:Smp_000650 EMBL CAZ27764.1OrganismSchistosoma Xenopus tropicalis (Western clawed frog) mansoni (Blood fluke) ARP38212_T100 A4IIN1_XENTR Siah2 protein (Silurana tropicalis) 318 92.00% ORF Names:Smp_000650 EMBL CAZ27764.1OrganismSchistosoma E3 ubiquitin‐protein ligase siah2 (EC 6.3.2.‐) mansoni (Blood fluke) ARP38212_T100 SIAH2_XENLA (Seven in absentia homolog 2) (Xsiah‐2) Xenopus laevis (African clawed frog) 313 92.00% ARP48268_P050 Q7SYT1_XENLA Prdx6‐prov protein Xenopus laevis (African clawed frog) 224 100.00% ARP48268_P050 Q7SYQ4_XENLA MGC64582 protein Xenopus laevis (African clawed frog) 224 92.00% Xenopus tropicalis (Western clawed frog) ARP52806_P050 Q0P4H9_XENTR Putative uncharacterized protein MGC147453 (Silurana tropicalis) 274 92.00% T ARP32363_T100 Q6INQ0_XENLA MGC81453 protein Xenopus laevis (African clawed frog) 432 92.00% Xenopus tropicalis (Western clawed frog) T ARP32363_T100 Q66IH3_XENTR T, brachyury homolog (Silurana tropicalis) 434 92.00% Xenopus tropicalis (Western clawed frog) T ARP32363_T100 Q28GC9_XENTR T, brachyury homolog (Mouse) (Silurana tropicalis) 433 92.00% T ARP32363_T100 O42599_XENLA Xbra2 protein (Fragment) Xenopus laevis (African clawed frog) 67 92.00% T ARP32363_T100 BRAC_XENLA Brachyury protein (xBRA) (Protein T) Xenopus laevis (African clawed frog) 432 92.00% T ARP32363_T100 Q9W7R8_XENLA Brachyury‐like T‐box transcription factor Xenopus laevis (African clawed frog) 434 84.00% T, brachyury homolog, gene 2 (T2, brachyury Xenopus tropicalis (Western clawed frog) T ARP32363_T100 Q6NX23_XENTR homolog (Mouse)) (Silurana tropicalis) 434 84.00% T ARP32363_T100 B7ZRC9_XENLA Brachyury‐like T‐box transcription factor Xenopus laevis (African clawed frog) 434 84.00% KRT5 ARP42029_P050 A2BDA9_XENLA LOC100037087 protein Xenopus laevis (African clawed frog) 490 92.00%

KRT5 ARP42029_P050 K2C5_XENLA Keratin, type II cytoskeletal (XENCK55(5/6)) Xenopus laevis (African clawed frog) 513 78.00% Xenopus tropicalis (Western clawed frog) KRT5 ARP42029_P050 B1H1E8_XENTR Krt5.7 protein (Fragment) (Silurana tropicalis) 537 78.00% ARP53578_P050 Q7ZYG7_XENLA Ap2b1‐prov protein Xenopus laevis (African clawed frog) 951 100.00% Adaptor‐related protein complex 2, beta 1 Xenopus tropicalis (Western clawed frog) ARP53578_P050 Q6P4L7_XENTR subunit (Silurana tropicalis) 951 100.00% Xenopus tropicalis (Western clawed frog) RECQL5 ARP36360_P050 B4F6V5_XENTR Putative uncharacterized protein (Silurana tropicalis) 1050 100.00% Xenopus tropicalis (Western clawed frog) ARP39706_P050 Q6DEX8_XENTR MGC89425 protein (Silurana tropicalis) 737 85.00% Xenopus tropicalis (Western clawed frog) ARP39706_P050 Q5I084_XENTR MGC89425 protein (Fragment) (Silurana tropicalis) 383 85.00% ARP39706_P050 KDM2B_XENLA Isoform 2 Xenopus laevis (African clawed frog) 738 85.00%

Lysine‐specific demethylase 2B (EC 1.14.11.27) (F‐box and leucine‐rich repeat protein 10) (F‐box/LRR‐repeat protein 10) (JmjC domain‐containing histone demethylation protein 1B) ([Histone‐H3]‐ ARP39706_P050 KDM2B_XENLA lysine‐36 demethylase 1B) Xenopus laevis (African clawed frog) 1259 85.00% Hnrnph2 ARP40721_T100 Q640J5_XENLA LOC494658 protein Xenopus laevis (African clawed frog) 342 100.00% Xenopus tropicalis (Western clawed frog) Hnrnph2 ARP40721_T100 B5DEU6_XENTR Hnrnph3 protein (Silurana tropicalis) 413 100.00% Xenopus tropicalis (Western clawed frog) Hnrnph2 ARP40721_T100 B2GUJ1_XENTR Hnrnph3 protein (Silurana tropicalis) 416 100.00% Hnrnph2 ARP40721_T100 Q6IRC9_XENLA MGC78776 protein Xenopus laevis (African clawed frog) 441 85.00%

Heterogeneous nuclear ribonucleoprotein H2 Xenopus tropicalis (Western clawed frog) Hnrnph2 ARP40721_T100 Q6GL26_XENTR (H') (OTTXETP00000011092) (Silurana tropicalis) 441 85.00% Hnrnph2 ARP40721_T100 Q6DD57_XENLA Hnrph2 protein (Hnrph2‐prov protein) Xenopus laevis (African clawed frog) 456 85.00% RNF13 ARP34147_P050 Q6P414_XENLA MGC68556 protein Xenopus laevis (African clawed frog) 381 78.00% Xenopus tropicalis (Western clawed frog) RNF13 ARP34147_P050 Q66JJ1_XENTR Ring finger protein 13 (Silurana tropicalis) 383 78.00% Xenopus tropicalis (Western clawed frog) ARP41757_P050 Q5FVW1_XENTR Coagulation factor 2 (Thrombin) (Silurana tropicalis) 607 76.00% ARP41757_P050 Q6GNK4_XENLA LOC443652 protein (Fragment) Xenopus laevis (African clawed frog) 615 76.00% ARP41757_P050 Q6DFJ5_XENLA Lpa‐prov protein Xenopus laevis (African clawed frog) 607 76.00% ARP41757_P050 Q4QR53_XENLA LOC443652 protein Xenopus laevis (African clawed frog) 607 76.00% PPME1 ARP56845_P050 Q6DKB6_XENLA MGC84679 protein Xenopus laevis (African clawed frog) 140 78.00% Xenopus tropicalis (Western clawed frog) pnn ARP56403_P050 Q6DJ99_XENTR Pinin, desmosome associated protein (Silurana tropicalis) 691 92.00% pnn ARP56403_P050 O73619_XENLA Nuclear protein Xenopus laevis (African clawed frog) 718 92.00% pnn ARP56403_P050 A2VDA0_XENLA Np‐a protein Xenopus laevis (African clawed frog) 711 92.00% pnn ARP56403_P050 Q52KX2_XENLA Sdk2‐a protein Xenopus laevis (African clawed frog) 689 84.00% pnn ARP56403_P050 O73620_XENLA Nuclear protein SDK2 Xenopus laevis (African clawed frog) 689 84.00% ARP53359_P050 Q498E5_XENLA Chc1‐b‐prov protein Xenopus laevis (African clawed frog) 325 78.00% st ARP46800_P050 Q6NU41_XENLA MGC81265 protein Xenopus laevis (African clawed frog) 351 100.00% Microphthalmia associated transcription MITF ARP37977_T100 Q804B9_XENLA factor type A (Fragment) Xenopus laevis (African clawed frog) 208 92.00% Micophthalmia‐associated transcription factor MITF ARP37977_T100 Q76DN5_XENLA type M Xenopus laevis (African clawed frog) 392 92.00% Micophthalmia‐associated transcription factor MITF ARP37977_T100 Q76DN4_XENLA type A Xenopus laevis (African clawed frog) 483 92.00% Microphthalmia‐associated transcription MITF ARP37977_T100 Q76DN3_XENLA factor type M Xenopus laevis (African clawed frog) 392 92.00% Micophthalmia‐associated transcription factor MITF ARP37977_T100 Q76DN2_XENLA type A Xenopus laevis (African clawed frog) 483 92.00%

MITF ARP37977_T100 B2GTX5_XENLA Putative uncharacterized protein (Fragment) Xenopus laevis (African clawed frog) 478 92.00% Xenopus tropicalis (Western clawed frog) MITF ARP37977_T100 A4IID0_XENTR Mitf protein (Silurana tropicalis) 483 92.00% MITF ARP37977_T100 Q5XHC0_XENLA LOC495043 protein Xenopus laevis (African clawed frog) 429 85.00% ‐8 ARP54916_P050 Q66IY7_XENLA MGC84050 protein Xenopus laevis (African clawed frog) 436 78.00% Xenopus tropicalis (Western clawed frog) dbp‐8 ARP54916_P050 B2GUK1_XENTR LOC100158600 protein (Fragment) (Silurana tropicalis) 434 78.00% Ncoa2 ARP38815_P050 B7ZSK8_XENLA Putative uncharacterized protein Xenopus laevis (African clawed frog) 1432 85.00% Nuclear receptor coactivator 2 (NCoA‐2) Xenopus tropicalis (Western clawed frog) Ncoa2 ARP38815_P050 NCOA2_XENTR (Transcriptional intermediary factor 2) (Silurana tropicalis) 1440 85.00%

Nuclear receptor coactivator 2 (NCoA‐2) Ncoa2 ARP38815_P050 NCOA2_XENLA (Transcriptional intermediary factor 2) (xTIF2) Xenopus laevis (African clawed frog) 1516 85.00% Peptidylprolyl isomerase (Cyclophilin)‐like 2 Xenopus tropicalis (Western clawed frog) ppil2 ARP55026_P050 Q28F17_XENTR (Fragment) (Silurana tropicalis) 195 78.00% Xenopus tropicalis (Western clawed frog) ppil2 ARP55026_P050 B0BMK4_XENTR Ppil2 protein (Silurana tropicalis) 521 78.00% Xenopus tropicalis (Western clawed frog) ppil2 ARP55026_P050 B0BLU8_XENTR Putative uncharacterized protein (Fragment) (Silurana tropicalis) 461 78.00%

Transcription factor AP‐2 gamma (Activating Xenopus tropicalis (Western clawed frog) tfap2b ARP38282_P050 Q5XGF5_XENTR enhancer binding protein 2 gamma) (Silurana tropicalis) 442 78.00%

Transcription factor AP‐2 gamma (Activating Xenopus tropicalis (Western clawed frog) tfap2b ARP38282_P050 Q28F74_XENTR enhancer binding protein 2 gamma) (Silurana tropicalis) 444 78.00% ARP51694_P050 INT4_XENLA Integrator complex subunit 4 (Int4) Xenopus laevis (African clawed frog) 969 85.00% ARP40811_P050 Q800L7_XENLA Pumilio Xenopus laevis (African clawed frog) 1185 78.00% pum1 ARP40811_P050 Q66KI6_XENLA Pum1‐A protein Xenopus laevis (African clawed frog) 1190 78.00% Rap1gap ARP56511_P050 Q5XKA5_XENLA LOC494835 protein Xenopus laevis (African clawed frog) 186 85.00% ORF Names:OsI_01354 EMBL EAY73474.1OrganismOryza sativa subsp. indica (Rice) ARP43091_P050 Q5I005_XENLA LOC496302 protein Xenopus laevis (African clawed frog) 179 78.00% TPPC2 ARP50568_P050 Q641A5_XENLA LOC494644 protein Xenopus laevis (African clawed frog) 140 78.00%

Putative uncharacterized protein LOC549396 Xenopus tropicalis (Western clawed frog) TPPC2 ARP50568_P050 Q28IG8_XENTR (Trafficking protein particle complex 2) (Silurana tropicalis) 140 83.00% SUMO‐conjugating enzyme UBC9 (EC 6.3.2.‐) (SUMO‐protein ligase) (Ubiquitin carrier ORF Names:ACLA_046110 EMBL protein 9) (Ubiquitin carrier protein I) EAW10146.1OrganismAspergillus (Ubiquitin‐conjugating enzyme E2 I) (Ubiquitin‐Xenopus tropicalis (Western clawed frog) clavatus ARP43022_T100 UBC9_XENTR protein ligase I) (Silurana tropicalis) 158 100.00% SUMO‐conjugating enzyme UBC9 (EC 6.3.2.‐) (SUMO‐protein ligase) (Ubiquitin carrier ORF Names:ACLA_046110 EMBL protein 9) (Ubiquitin carrier protein I) EAW10146.1OrganismAspergillus (Ubiquitin‐conjugating enzyme E2 I) (Ubiquitin‐ clavatus ARP43022_T100 UBC9_XENLA protein ligase I) Xenopus laevis (African clawed frog) 158 100.00% Xenopus tropicalis (Western clawed frog) fkbp8 ARP46863_P050 B0JZR5_XENTR LOC100145224 protein (Silurana tropicalis) 406 100.00% fkbp8 ARP46863_P050 Q5XGM2_XENLA LOC495188 protein (Fragment) Xenopus laevis (African clawed frog) 370 85.00% Xenopus tropicalis (Western clawed frog) fkbp8 ARP46863_P050 B1WAX8_XENTR LOC100145724 protein (Silurana tropicalis) 408 85.00% fkbp8 ARP46863_P050 A1L2N1_XENLA LOC495188 protein Xenopus laevis (African clawed frog) 408 85.00% Map2k6 ARP42065_P050 Q9PW48_XENLA MAP kinase activator XMEK3 Xenopus laevis (African clawed frog) 335 85.00% Map2k6 ARP42065_P050 Q6PF61_XENLA MGC68865 protein Xenopus laevis (African clawed frog) 335 85.00%

Mitogen activated protein kinase kinase 6 Xenopus tropicalis (Western clawed frog) Map2k6 ARP42065_P050 Q6GL46_XENTR (Mitogen‐activated protein kinase kinase 6) (Silurana tropicalis) 335 85.00% Map2k6 ARP42065_P050 Q6AZK0_XENLA Map2k3 protein Xenopus laevis (African clawed frog) 335 85.00% Epithelial splicing regulatory protein 1 (RNA‐ binding motif protein 35A) (RNA‐binding Xenopus tropicalis (Western clawed frog) Esrp1 ARP42489_T100 ESRP1_XENTR protein 35A) (Silurana tropicalis) 687 85.00% Epithelial splicing regulatory protein 1 (RNA‐ binding motif protein 35A) (RNA‐binding Esrp1 ARP42489_T100 ESRP1_XENLA protein 35A) Xenopus laevis (African clawed frog) 688 85.00% ARP40442_P050 Q641E8_XENLA MGC81833 protein Xenopus laevis (African clawed frog) 255 100.00% dtnb ARP46310_P050 Q6NU81_XENLA MGC81161 protein Xenopus laevis (African clawed frog) 680 100.00% Xenopus tropicalis (Western clawed frog) dtnb ARP46310_P050 Q0V9N3_XENTR Dystrobrevin alpha (Silurana tropicalis) 683 100.00% dtnb ARP46310_P050 Q7ZX13_XENLA Dtna‐A protein Xenopus laevis (African clawed frog) 743 92.00% LCB1 ARP46722_P050 Q6IRQ6_XENLA MGC81520 protein Xenopus laevis (African clawed frog) 472 92.00% Xenopus tropicalis (Western clawed frog) LCB1 ARP46722_P050 Q0VGY2_XENTR Putative uncharacterized protein MGC79656 (Silurana tropicalis) 472 92.00%

Alanine aminotransferase 2 (ALT2) (EC 2.6.1.2) (Glutamate pyruvate transaminase 2) (GPT 2) (Glutamic‐‐alanine transaminase 2) (Glutamic‐‐ Xenopus tropicalis (Western clawed frog) GPT ARP45710_T100 ALAT2_XENTR pyruvic transaminase 2) (Silurana tropicalis) 524 85.00%

Alanine aminotransferase 2 (ALT2) (EC 2.6.1.2) (Glutamate pyruvate transaminase 2) (GPT 2) (Glutamic‐‐alanine transaminase 2) (Glutamic‐‐ GPT ARP45710_T100 ALAT2_XENLA pyruvic transaminase 2) Xenopus laevis (African clawed frog) 540 85.00% Xenopus tropicalis (Western clawed frog) ARP54679_P050 Q6P4X0_XENTR Putative uncharacterized protein MGC76184 (Silurana tropicalis) 538 78.00% Xenopus tropicalis (Western clawed frog) ARP54679_P050 Q642T8_XENTR Kpna6 protein (Silurana tropicalis) 534 78.00% Xenopus tropicalis (Western clawed frog) ftcd ARP41577_P050 Q6DEY5_XENTR Formiminotransferase cyclodeaminase (Silurana tropicalis) 540 85.00% Xenopus tropicalis (Western clawed frog) ftcd ARP41577_P050 Q28EV1_XENTR Formiminotransferase cyclodeaminase (Silurana tropicalis) 540 85.00% ftcd ARP41577_P050 Q7SYV7_XENLA MGC64458 protein Xenopus laevis (African clawed frog) 469 85.00%

ORF Names:CfE428DRAFT_1769 EMBL EDY20572.1OrganismChthoniobacter flavus Ellin428 ARP40733_T100 Q7ZYA4_XENLA Sf3b1 protein (Fragment) Xenopus laevis (African clawed frog) 500 92.00%

ORF Names:CfE428DRAFT_1769 EMBL EDY20572.1OrganismChthoniobacter flavus Ellin428 ARP40733_T100 Q4QR12_XENLA Sf3b1 protein Xenopus laevis (African clawed frog) 814 92.00% ORF Names:CfE428DRAFT_1769 EMBL EDY20572.1OrganismChthoniobacter Xenopus tropicalis (Western clawed frog) flavus Ellin428 ARP40733_T100 A7MC63_XENTR LOC100127558 protein (Fragment) (Silurana tropicalis) 496 92.00%

Splicing factor 3B subunit 1 (146 kDa nuclear ORF Names:CfE428DRAFT_1769 EMBL protein) (Pre‐mRNA‐splicing factor SF3b 155 EDY20572.1OrganismChthoniobacter kDa subunit) (SF3b155) (Spliceosome‐ flavus Ellin428 ARP40733_T100 SF3B1_XENLA associated protein 155) (SAP 155) Xenopus laevis (African clawed frog) 1307 92.00% SF1 ARP33493_P050 Q7ZWT3_XENLA Sf1 protein Xenopus laevis (African clawed frog) 571 92.00% Xenopus tropicalis (Western clawed frog) SF1 ARP33493_P050 Q5M7R7_XENTR Splicing factor 1 (Silurana tropicalis) 571 92.00% TMOD1 ARP55080_P050 A1DPK8_XENLA Tropomodulin Xenopus laevis (African clawed frog) 344 92.00% TMOD1 ARP55080_P050 Q7ZWK9_XENLA Tmod3‐prov protein Xenopus laevis (African clawed frog) 344 91.00% LOC549678 protein (Tropomodulin 3 Xenopus tropicalis (Western clawed frog) TMOD1 ARP55080_P050 Q28ET7_XENTR (Ubiquitous)) (Silurana tropicalis) 344 91.00% Xenopus tropicalis (Western clawed frog) TMOD1 ARP55080_P050 A8WGI0_XENTR LOC100127704 protein (Silurana tropicalis) 352 78.00% TMOD1 ARP55080_P050 Q66KN0_XENLA MGC85587 protein Xenopus laevis (African clawed frog) 346 75.00% Xenopus tropicalis (Western clawed frog) TMOD1 ARP55080_P050 Q28J87_XENTR Tropomodulin 4 (Muscle) (Silurana tropicalis) 346 75.00% Cacnb1 ARP34954_P050 A8WH49_XENLA LOC100127255 protein (Fragment) Xenopus laevis (African clawed frog) 498 85.00% Xenopus tropicalis (Western clawed frog) Cacnb1 ARP34954_P050 B2GU78_XENTR LOC100158521 protein (Silurana tropicalis) 583 78.00% Gpdh ARP42228_P050 Q6GN03_XENLA MGC83663 protein Xenopus laevis (African clawed frog) 349 92.00% Glycerol‐3‐phosphate dehydrogenase 1‐like Xenopus tropicalis (Western clawed frog) Gpdh ARP42228_P050 GPD1L_XENTR protein (EC 1.1.1.8) (Silurana tropicalis) 352 85.00% Glycerol‐3‐phosphate dehydrogenase 1‐like Gpdh ARP42228_P050 GPD1L_XENLA protein (EC 1.1.1.8) Xenopus laevis (African clawed frog) 352 85.00% Gpdh ARP42228_P050 Q7ZYM3_XENLA Gpd1 protein Xenopus laevis (African clawed frog) 348 85.00% Glycerol‐3‐phosphate dehydrogenase 1 (Soluble) (Glycerol‐3‐phosphate Xenopus tropicalis (Western clawed frog) Gpdh ARP42228_P050 Q6DFQ1_XENTR dehydrogenase 1‐like) (Silurana tropicalis) 348 85.00% Xenopus tropicalis (Western clawed frog) ARP35491_P050 A9UM33_XENTR LOC100135241 protein (Silurana tropicalis) 259 85.00% RNFT2 ARP50130_P050 Q66IT4_XENLA LOC446942 protein (Fragment) Xenopus laevis (African clawed frog) 390 100.00%

ORF Names:v1g212385OrganismNematostel Xenopus tropicalis (Western clawed frog) la vectensis (Starlet sea anemone) ARP31239_P050 B2GU39_XENTR Tead1 protein (Fragment) (Silurana tropicalis) 513 92.00% ORF Names:v1g212385OrganismNematostel la vectensis (Starlet sea anemone) ARP31239_P050 A8CSN2_XENLA TEF‐1 Xenopus laevis (African clawed frog) 426 92.00% Ordered Locus Names:Tpen_1732OrganismThermofilu m pendens (strain Hrk 5) ARP34655_P050 Q5XGT0_XENLA LOC495149 protein (Fragment) Xenopus laevis (African clawed frog) 1029 78.00% Ordered Locus Names:Tpen_1732OrganismThermofilu Xenopus tropicalis (Western clawed frog) m pendens (strain Hrk 5) ARP34655_P050 B1H2W2_XENTR LOC100124805 protein (Fragment) (Silurana tropicalis) 729 78.00% Sdf2 ARP48719_P050 Q640E3_XENLA LOC494694 protein Xenopus laevis (African clawed frog) 218 85.00% Xenopus tropicalis (Western clawed frog) Sdf2 ARP48719_P050 Q28HH8_XENTR Stromal cell‐derived factor 2 (Silurana tropicalis) 218 85.00% MGC79547 protein (Stromal cell‐derived Xenopus tropicalis (Western clawed frog) Sdf2 ARP48719_P050 Q66JH3_XENTR factor 2‐like 1) (Silurana tropicalis) 218 78.00% Sdf2 ARP48719_P050 Q5PPW6_XENLA LOC496057 protein Xenopus laevis (African clawed frog) 218 78.00% Xenopus tropicalis (Western clawed frog) Kdm6a ARP39483_P050 B3DLW8_XENTR LOC100170558 protein (Silurana tropicalis) 1403 76.00% Kdm6b ARP40102_T100 Q6AZS3_XENLA Uty‐prov protein Xenopus laevis (African clawed frog) 1455 76.00% LOC100124929 ARP38104_P050 Q8JGL7_XENLA RAP74 subunit of transcription factor IIF Xenopus laevis (African clawed frog) 524 85.00% LOC100124929 ARP38104_P050 Q7ZYS6_XENLA LOC398325 protein (Fragment) Xenopus laevis (African clawed frog) 343 85.00% General transcription factor IIF subunit 1 (Transcription initiation factor IIF subunit alpha) (TFIIF‐alpha) (Transcription initiation LOC100124929 ARP38104_P050 T2FA_XENLA factor RAP74) Xenopus laevis (African clawed frog) 524 85.00% Xenopus tropicalis (Western clawed frog) LOC100124929 ARP38104_P050 B1H3B7_XENTR LOC100124929 protein (Silurana tropicalis) 522 78.00% Xenopus tropicalis (Western clawed frog) LOC100124929 ARP38104_P050 A4II08_XENTR LOC100124929 protein (Fragment) (Silurana tropicalis) 371 78.00% Cuedc1 ARP42500_T100 Q801S9_XENLA MGC53385 protein Xenopus laevis (African clawed frog) 376 92.00% Cuedc1 ARP42500_T100 Q2T9K3_XENLA MGC131110 protein Xenopus laevis (African clawed frog) 377 92.00% Xenopus tropicalis (Western clawed frog) Cuedc1 ARP42500_T100 Q28CL8_XENTR Novel protein containing CUE domain (Silurana tropicalis) 373 85.00% Xenopus tropicalis (Western clawed frog) Cuedc1 ARP42500_T100 B7ZUF9_XENTR Putative uncharacterized protein LOC548971 (Silurana tropicalis) 373 85.00% Xenopus tropicalis (Western clawed frog) mrpl47 ARP57768_P050 A9UMT4_XENTR LOC100135398 protein (Silurana tropicalis) 135 92.00% ZBT11 ARP39083_P050 Q6DCC1_XENLA ZBTB11 protein (Fragment) Xenopus laevis (African clawed frog) 632 92.00% Xenopus tropicalis (Western clawed frog) ZBT11 ARP39083_P050 Q28BM5_XENTR Zinc finger and BTB domain containing 11 (Silurana tropicalis) 352 92.00% SGCE ARP46387_P050 Q56A58_XENLA MGC115066 protein Xenopus laevis (African clawed frog) 304 92.00% ENDOG ARP52054_P050 Q5PQ48_XENLA LOC495982 protein Xenopus laevis (African clawed frog) 290 91.00% LOC100037190 ARP32409_T100 Q6GPW5_XENLA MGC82564 protein Xenopus laevis (African clawed frog) 331 84.00% LOC100037190 ARP32409_T100 A2VD90_XENLA LOC100037190 protein Xenopus laevis (African clawed frog) 331 78.00% Xenopus tropicalis (Western clawed frog) Mcm8 ARP36658_P050 Q0V9Q6_XENTR Minichromosome maintenance protein 8 (Silurana tropicalis) 843 92.00% Xenopus tropicalis (Western clawed frog) Mcm8 ARP36658_P050 A4IIB8_XENTR MGC146393 protein (Silurana tropicalis) 675 92.00% ORF Names:zgc:162972 EMBL AAI34176.1 ZFIN ZDB‐GENE‐070424‐ 49OrganismDanio rerio (Zebrafish) Xenopus tropicalis (Western clawed frog) (Brachydanio rerio) ARP50879_P050 Q28CS9_XENTR Novel zinc finger protein (Silurana tropicalis) 583 92.00% LOC100037141 ARP40180_P050 Q91831_XENLA Alpha‐tubulin Xenopus laevis (African clawed frog) 450 100.00% LOC100037141 ARP40180_P050 Q7ZYU9_XENLA Alphatub84b‐prov protein Xenopus laevis (African clawed frog) 452 100.00% LOC100037141 ARP40180_P050 Q7ZWQ5_XENLA Tuba6‐prov protein Xenopus laevis (African clawed frog) 449 100.00% LOC100037141 ARP40180_P050 Q7ZTP0_XENLA MGC53359 protein Xenopus laevis (African clawed frog) 450 100.00% Xenopus tropicalis (Western clawed frog) LOC100037141 ARP40180_P050 Q6P8G7_XENTR Tubulin, alpha 1c (Tubulin, alpha 6) (Silurana tropicalis) 449 100.00% Xenopus tropicalis (Western clawed frog) LOC100037141 ARP40180_P050 Q6P8D2_XENTR Tubulin, alpha 1 (Silurana tropicalis) 451 100.00% Xenopus tropicalis (Western clawed frog) LOC100037141 ARP40180_P050 Q6NVN1_XENTR Tubulin, alpha 2 (Tubulin, alpha 4) (Silurana tropicalis) 450 100.00% LOC100037141 ARP40180_P050 Q6NRV3_XENLA MGC81323 protein Xenopus laevis (African clawed frog) 450 100.00% LOC100037141 ARP40180_P050 Q6DD58_XENLA Mec‐12 protein Xenopus laevis (African clawed frog) 448 100.00% LOC100037141 ARP40180_P050 Q5U4V6_XENLA LOC397931 protein Xenopus laevis (African clawed frog) 450 100.00% Xenopus tropicalis (Western clawed frog) LOC100037141 ARP40180_P050 Q5EB23_XENTR MGC97820 protein (Silurana tropicalis) 449 100.00% Xenopus tropicalis (Western clawed frog) LOC100037141 ARP40180_P050 Q28CR6_XENTR Tubulin, alpha 2 (Fragment) (Silurana tropicalis) 442 100.00% Novel protein similar to tubulin, alpha 1 Xenopus tropicalis (Western clawed frog) LOC100037141 ARP40180_P050 Q28CH9_XENTR (Tuba1) (Silurana tropicalis) 414 100.00% Novel protein similar to tubulin, alpha 1 Xenopus tropicalis (Western clawed frog) LOC100037141 ARP40180_P050 Q28C42_XENTR (Tuba1) (Silurana tropicalis) 449 100.00% Xenopus tropicalis (Western clawed frog) LOC100037141 ARP40180_P050 B7ZTG2_XENTR Tubulin, alpha 4b (Silurana tropicalis) 449 100.00% Xenopus tropicalis (Western clawed frog) LOC100037141 ARP40180_P050 B0BMH2_XENTR Tuba4a protein (Silurana tropicalis) 451 100.00% Novel protein similar to tubulin, alpha 1 Xenopus tropicalis (Western clawed frog) LOC100037141 ARP40180_P050 A4IGU4_XENTR (Tuba1) (Silurana tropicalis) 449 100.00% LOC100037141 ARP40180_P050 A2RV72_XENLA LOC100037141 protein Xenopus laevis (African clawed frog) 449 100.00%

ORF Names:CpipJ_CPIJ016568 EMBL EDS44940.1, CpipJ_CPIJ020000 EMBL EDS33702.1OrganismCulex quinquefasciatus (Southern house CHRAC17 protein (DNA polymerase epsilon mosquito) (Culex pungens) ARP58048_P050 Q6WSQ3_XENLA p17 subunit) (Histone‐fold protein CHRAC17) Xenopus laevis (African clawed frog) 147 92.00% ORF Names:CpipJ_CPIJ016568 EMBL EDS44940.1, CpipJ_CPIJ020000 EMBL EDS33702.1OrganismCulex quinquefasciatus (Southern house Polymerase (DNA directed), epsilon 3 (P17 Xenopus tropicalis (Western clawed frog) mosquito) (Culex pungens) ARP58048_P050 Q28J93_XENTR subunit) (Silurana tropicalis) 147 92.00%

Ordered Locus Names:GTNG_1595OrganismGeobacillu s thermodenitrificans (strain NG80‐2) ARP40284_T100 Q7ZY06_XENLA U2af2 protein Xenopus laevis (African clawed frog) 456 100.00%

Ordered Locus Names:GTNG_1595OrganismGeobacillu U2 small nuclear ribonucleoprotein auxiliary Xenopus tropicalis (Western clawed frog) s thermodenitrificans (strain NG80‐2) ARP40284_T100 Q6NVN9_XENTR factor (U2AF) 2 (Silurana tropicalis) 456 100.00%

Ordered Locus Names:GTNG_1595OrganismGeobacillu U2 (RNU2) small nuclear RNA auxiliary factor Xenopus tropicalis (Western clawed frog) s thermodenitrificans (strain NG80‐2) ARP40284_T100 Q28EQ0_XENTR 2 (U2 small nuclear RNA auxiliary factor 2) (Silurana tropicalis) 465 100.00%

Alanine aminotransferase 2 (ALT2) (EC 2.6.1.2) (Glutamate pyruvate transaminase 2) (GPT 2) (Glutamic‐‐alanine transaminase 2) (Glutamic‐‐ Xenopus tropicalis (Western clawed frog) gpt2 ARP45712_T100 ALAT2_XENTR pyruvic transaminase 2) (Silurana tropicalis) 524 78.00%

Alanine aminotransferase 2 (ALT2) (EC 2.6.1.2) (Glutamate pyruvate transaminase 2) (GPT 2) (Glutamic‐‐alanine transaminase 2) (Glutamic‐‐ gpt2 ARP45712_T100 ALAT2_XENLA pyruvic transaminase 2) Xenopus laevis (African clawed frog) 540 78.00%

ORF Names:DKEY‐202N14.4‐001 EMBL CAM15332.1OrganismDanio rerio (Zebrafish) (Brachydanio rerio) ARP38141_P050 B7ZPQ0_XENLA Mxd1 protein Xenopus laevis (African clawed frog) 221 100.00%

ORF Names:DKEY‐202N14.4‐001 EMBL CAM15332.1OrganismDanio rerio Max dimerization protein 1 (Max dimerizer 1) Xenopus tropicalis (Western clawed frog) (Zebrafish) (Brachydanio rerio) ARP38141_P050 MAD1_XENTR (Protein MAD) (Silurana tropicalis) 221 100.00%

ORF Names:DKEY‐202N14.4‐001 EMBL CAM15332.1OrganismDanio rerio Max dimerization protein 1 (Max dimerizer 1) (Zebrafish) (Brachydanio rerio) ARP38141_P050 MAD1_XENLA (Protein MAD) Xenopus laevis (African clawed frog) 221 100.00% ORF Names:DKEY‐202N14.4‐001 EMBL CAM15332.1OrganismDanio rerio Xenopus tropicalis (Western clawed frog) (Zebrafish) (Brachydanio rerio) ARP38141_P050 B3DLA4_XENTR MAX dimerization protein 3 (Silurana tropicalis) 200 100.00%

ORF Names:DKEY‐202N14.4‐001 EMBL Max dimerization protein 3 (Max dimerizer 3) CAM15332.1OrganismDanio rerio (Max‐associated protein 3) (Max‐interacting Xenopus tropicalis (Western clawed frog) (Zebrafish) (Brachydanio rerio) ARP38141_P050 MAD3_XENTR transcriptional repressor MAD3) (Silurana tropicalis) 200 100.00%

ORF Names:DKEY‐202N14.4‐001 EMBL Max dimerization protein 3 (Max dimerizer 3) CAM15332.1OrganismDanio rerio (Max‐associated protein 3) (Max‐interacting (Zebrafish) (Brachydanio rerio) ARP38141_P050 MAD3_XENLA transcriptional repressor MAD3) Xenopus laevis (African clawed frog) 200 100.00%

ORF Names:DKEY‐202N14.4‐001 EMBL CAM15332.1OrganismDanio rerio Basic helix‐loop‐helix transcription factor (Zebrafish) (Brachydanio rerio) ARP38141_P050 Q9W6H3_XENLA XMad4‐67 Xenopus laevis (African clawed frog) 67 92.00%

ORF Names:DKEY‐202N14.4‐001 EMBL CAM15332.1OrganismDanio rerio Basic helix‐loop‐helix transcription factor (Zebrafish) (Brachydanio rerio) ARP38141_P050 Q9W6H2_XENLA XMad4‐236 Xenopus laevis (African clawed frog) 236 92.00%

ORF Names:DKEY‐202N14.4‐001 EMBL Basic helix‐loop‐helix transcription factor CAM15332.1OrganismDanio rerio XMad4 (Basic helix‐loop‐helix transcription (Zebrafish) (Brachydanio rerio) ARP38141_P050 Q9W6H1_XENLA factor XMad4‐204) Xenopus laevis (African clawed frog) 204 92.00%

ORF Names:DKEY‐202N14.4‐001 EMBL CAM15332.1OrganismDanio rerio Xenopus tropicalis (Western clawed frog) (Zebrafish) (Brachydanio rerio) ARP38141_P050 A4IH47_XENTR LOC100124794 protein (Silurana tropicalis) 204 92.00%

ORF Names:DKEY‐202N14.4‐001 EMBL CAM15332.1OrganismDanio rerio (Zebrafish) (Brachydanio rerio) ARP38141_P050 Q5HZZ5_XENLA Xmad4 protein Xenopus laevis (African clawed frog) 203 84.00% Xenopus tropicalis (Western clawed frog) LYSMD1 ARP56012_P050 A4II05_XENTR LOC100124927 protein (Silurana tropicalis) 218 76.00% LysM and putative peptidoglycan‐binding LYSMD1 ARP56012_P050 LYSM1_XENLA domain‐containing protein 1 Xenopus laevis (African clawed frog) 215 76.00% UBA3 ARP50493_P050 Q3B8H8_XENLA MGC131020 protein Xenopus laevis (African clawed frog) 461 92.00% Xenopus tropicalis (Western clawed frog) UBA3 ARP50493_P050 B5DFR3_XENTR Uba3 protein (Silurana tropicalis) 442 92.00% Xenopus tropicalis (Western clawed frog) UBA3 ARP50493_P050 B1H132_XENTR Uba3 protein (Silurana tropicalis) 449 92.00% Xenopus tropicalis (Western clawed frog) PRR11 ARP51175_P050 Q0P4U6_XENTR Putative uncharacterized protein MGC145636 (Silurana tropicalis) 402 84.00% Xenopus tropicalis (Western clawed frog) PRR11 ARP51175_P050 Q5FVW5_XENTR LOC548379 protein (Fragment) (Silurana tropicalis) 353 75.00% Xenopus tropicalis (Western clawed frog) PRR11 ARP51175_P050 Q28H33_XENTR Novel protein (Silurana tropicalis) 353 75.00% Xenopus tropicalis (Western clawed frog) PRR11 ARP51175_P050 Q0VFT4_XENTR Putative uncharacterized protein (Fragment) (Silurana tropicalis) 363 75.00% ZNF507 ARP35888_P050 Q6NU43_XENLA MGC81262 protein Xenopus laevis (African clawed frog) 737 84.00% UDP‐N‐acetyl‐alpha‐D‐ galactosamine:polypeptide N‐ Xenopus tropicalis (Western clawed frog) galntl1 ARP49540_P050 Q28CC6_XENTR acetylgalactosaminyltransferase‐like 1 (Silurana tropicalis) 562 85.00% galntl1 ARP49540_P050 A5PKR1_XENLA LOC100101309 protein Xenopus laevis (African clawed frog) 563 85.00% rnf10 ARP39149_P050 RNF10_XENLA RING finger protein 10 Xenopus laevis (African clawed frog) 756 85.00% ercc5 ARP54287_P050 Q6DDY8_XENLA XPGC protein Xenopus laevis (African clawed frog) 1197 85.00% DNA repair protein complementing XP‐G cells homolog (EC 3.1.‐.‐) (Xeroderma pigmentosum group G‐complementing ercc5 ARP54287_P050 ERCC5_XENLA protein homolog) Xenopus laevis (African clawed frog) 1196 85.00% Xenopus tropicalis (Western clawed frog) ercc5 ARP54287_P050 A4IJ07_XENTR Ercc5 protein (Silurana tropicalis) 847 85.00% ORF Names:PTD2_19360 EMBL EAR28012.1OrganismPseudoalteromon Xenopus tropicalis (Western clawed frog) as tunicata D2 ARP41818_P050 A9UMG1_XENTR LOC100135344 protein (Silurana tropicalis) 219 78.00% Xenopus tropicalis (Western clawed frog) KHC ARP33903_P050 B3DLW6_XENTR Kif5b protein (Silurana tropicalis) 962 78.00% KHC ARP33903_P050 A5XAW2_XENLA Kinesin heavy chain (Fragment) Xenopus laevis (African clawed frog) 962 78.00% Xenopus tropicalis (Western clawed frog) ARP48856_P050 Q640V1_XENTR MGC88978 protein (Silurana tropicalis) 389 91.00% Xenopus tropicalis (Western clawed frog) Wwp2 ARP43088_P050 Q0VA08_XENTR Wwp2 protein (Silurana tropicalis) 729 80.00%

ORF Names:GSPATT00010912001 Ubiquitin‐like modifier‐activating enzyme 5 EMBL (Ubiquitin‐activating enzyme 5) (UFM1‐ CAK74744.1OrganismParamecium activating enzyme) (Ubiquitin‐activating Xenopus tropicalis (Western clawed frog) tetraurelia ARP49880_P050 UBA5_XENTR enzyme E1 domain‐containing protein 1) (Silurana tropicalis) 399 100.00%

ORF Names:GSPATT00010912001 Ubiquitin‐like modifier‐activating enzyme 5 EMBL (Ubiquitin‐activating enzyme 5) (UFM1‐ CAK74744.1OrganismParamecium activating enzyme) (Ubiquitin‐activating tetraurelia ARP49880_P050 UBA5_XENLA enzyme E1 domain‐containing protein 1) Xenopus laevis (African clawed frog) 397 100.00% GABRA2 ARP34984_P050 Q6AX36_XENLA MGC86282 protein Xenopus laevis (African clawed frog) 451 76.00% Xenopus tropicalis (Western clawed frog) GABRA2 ARP34984_P050 B3DM01_XENTR LOC100170583 protein (Fragment) (Silurana tropicalis) 499 76.00% Gamma‐aminobutyric acid A receptor subunit GABRA2 ARP34984_P050 E5LEX4_XENLA alpha‐1 (Fragment) Xenopus laevis (African clawed frog) 338 76.00% Xenopus tropicalis (Western clawed frog) PDLIM7 ARP38796_T100 Q28F15_XENTR Enigma homolog (Silurana tropicalis) 285 92.00% Xenopus tropicalis (Western clawed frog) PDLIM7 ARP38796_T100 B4ZJA9_XENTR PDZ and LIM domain 5 transcript variant (Silurana tropicalis) 583 92.00% PDLIM7 ARP38796_T100 A5PKP0_XENLA LOC100101292 protein Xenopus laevis (African clawed frog) 582 78.00% PDLIM7 ARP38796_T100 PDLI7_XENLA PDZ and LIM domain protein 7 Xenopus laevis (African clawed frog) 421 83.00% Putative uncharacterized protein Xenopus tropicalis (Western clawed frog) jak3 ARP54306_P050 B7ZU18_XENTR LOC100135373 (Silurana tropicalis) 1107 78.00% Xenopus tropicalis (Western clawed frog) jak3 ARP54306_P050 A9UMJ6_XENTR LOC100135373 protein (Silurana tropicalis) 1107 78.00% Xenopus tropicalis (Western clawed frog) mthfsd ARP40988_P050 A8E5T7_XENTR LOC100127601 protein (Silurana tropicalis) 415 85.00% mthfsd ARP40988_P050 MTHSD_XENLA Isoform 2 Xenopus laevis (African clawed frog) 415 85.00% Methenyltetrahydrofolate synthase domain‐ mthfsd ARP40988_P050 MTHSD_XENLA containing protein Xenopus laevis (African clawed frog) 415 85.00% Kcnma1 ARP37677_P050 KCMA1_XENLA Isoform 5 (Isoform xSlo99) Xenopus laevis (African clawed frog) 1295 92.00% Kcnma1 ARP37677_P050 KCMA1_XENLA Isoform 4 (Isoform xSlo59) Xenopus laevis (African clawed frog) 1252 92.00% Kcnma1 ARP37677_P050 KCMA1_XENLA Isoform 3 (Isoform xSlo56) Xenopus laevis (African clawed frog) 1255 92.00% Kcnma1 ARP37677_P050 KCMA1_XENLA Isoform 2 (Isoform xSlo15) Xenopus laevis (African clawed frog) 1211 92.00%

Calcium‐activated potassium channel subunit alpha‐1 (BK channel) (BKCA alpha) (Calcium‐ activated potassium channel, subfamily M subunit alpha‐1) (K(VCA)alpha) (KCa1.1) (Maxi K channel) (MaxiK) (Slo‐alpha) (Slo1) Kcnma1 ARP37677_P050 KCMA1_XENLA (Slowpoke homolog) (Slo homolog) (xSlo) Xenopus laevis (African clawed frog) 1196 92.00% RGD1309501 ARP56279_P050 Q6PA36_XENLA MGC68608 protein Xenopus laevis (African clawed frog) 210 92.00% zc3h7b ARP32500_T100 Q6DCZ5_XENLA MGC80522 protein Xenopus laevis (African clawed frog) 920 78.00% Man1a2 ARP46766_P050 Q6DFL1_XENLA Man1a2‐prov protein Xenopus laevis (African clawed frog) 643 92.00% Man1a2 ARP46766_P050 Q2TAS8_XENLA MGC130950 protein Xenopus laevis (African clawed frog) 643 92.00% Ergic2 ARP39265_T100 Q640X1_XENLA MGC81917 protein Xenopus laevis (African clawed frog) 377 92.00% Xenopus tropicalis (Western clawed frog) Ergic2 ARP39265_T100 Q28HM7_XENTR Ptx1 (Silurana tropicalis) 377 92.00% HSBP1 ARP35643_P050 Q5M7D3_XENLA Hsbp1b protein Xenopus laevis (African clawed frog) 77 92.00% Xenopus tropicalis (Western clawed frog) HSBP1 ARP35643_P050 Q5I0S3_XENTR binding protein 1 (Silurana tropicalis) 76 92.00% HSBP1 ARP35643_P050 A4FVE5_XENLA Hsbp1a protein Xenopus laevis (African clawed frog) 75 92.00% ATP‐gated subunit P2X4 p2rx4b ARP35512_P050 Q9DDP3_XENLA (Fragment) Xenopus laevis (African clawed frog) 384 83.00% p2rx4b ARP35512_P050 Q9DDP2_XENLA ATP‐gated ion channel subunit P2X4 Xenopus laevis (African clawed frog) 391 83.00% p2rx4b ARP35512_P050 Q9DDP1_XENLA ATP‐gated ion channel subunit P2X4 Xenopus laevis (African clawed frog) 391 83.00% p2rx4b ARP35512_P050 Q9DD61_XENLA ATP‐gated ion channel subunit P2X4 Xenopus laevis (African clawed frog) 391 83.00% dnali1 ARP53612_P050 Q6GN86_XENLA MGC82954 protein Xenopus laevis (African clawed frog) 254 85.00% Dynein, axonemal, light intermediate chain 1 (Dynein, axonemal, light intermediate Xenopus tropicalis (Western clawed frog) dnali1 ARP53612_P050 Q28IW2_XENTR polypeptide 1) (Silurana tropicalis) 254 85.00% Setx P100657_P050 Q6GNA9_XENLA MGC82910 protein Xenopus laevis (African clawed frog) 1093 92.00% Xenopus tropicalis (Western clawed frog) Setx P100657_P050 Q5EB46_XENTR Zinc finger E‐box binding homeobox 1 (Silurana tropicalis) 1099 92.00% Setx P100657_P050 Q1A551_XENLA Zinc finger homeobox 1a Xenopus laevis (African clawed frog) 1091 92.00%

ORF Names:v1g241911OrganismNematostel la vectensis (Starlet sea anemone) ARP40732_P050 Q7ZYA4_XENLA Sf3b1 protein (Fragment) Xenopus laevis (African clawed frog) 500 100.00%

ORF Names:v1g241911OrganismNematostel la vectensis (Starlet sea anemone) ARP40732_P050 Q4QR12_XENLA Sf3b1 protein Xenopus laevis (African clawed frog) 814 100.00%

ORF Names:v1g241911OrganismNematostel Xenopus tropicalis (Western clawed frog) la vectensis (Starlet sea anemone) ARP40732_P050 A7MC63_XENTR LOC100127558 protein (Fragment) (Silurana tropicalis) 496 100.00%

Splicing factor 3B subunit 1 (146 kDa nuclear ORF protein) (Pre‐mRNA‐splicing factor SF3b 155 Names:v1g241911OrganismNematostel kDa subunit) (SF3b155) (Spliceosome‐ la vectensis (Starlet sea anemone) ARP40732_P050 SF3B1_XENLA associated protein 155) (SAP 155) Xenopus laevis (African clawed frog) 1307 100.00% ORF Names:PANDA_012559 EMBL EFB19431.1OrganismAiluropoda melanoleuca (Giant panda) ARP49813_P050 Q5U5D2_XENLA LOC495296 protein Xenopus laevis (African clawed frog) 181 78.00%

Mediator of RNA polymerase II transcription MED23 ARP34880_P050 MED23_XENLA subunit 23 (Mediator complex subunit 23) Xenopus laevis (African clawed frog) 1369 85.00% ARP48226_P050 Q7ZX54_XENLA Vim4 protein Xenopus laevis (African clawed frog) 463 92.00% ARP48226_P050 Q7SZ33_XENLA Vim4 protein Xenopus laevis (African clawed frog) 463 92.00% Xenopus tropicalis (Western clawed frog) ARP48226_P050 Q5M8K3_XENTR Vim protein (Fragment) (Silurana tropicalis) 485 92.00% Xenopus tropicalis (Western clawed frog) ARP48226_P050 B5DES2_XENTR Vim protein (Silurana tropicalis) 461 92.00% Xenopus tropicalis (Western clawed frog) ARP48226_P050 A4IGY5_XENTR Vim protein (Fragment) (Silurana tropicalis) 484 92.00% ARP48226_P050 VIM4_XENLA Vimentin‐4 Xenopus laevis (African clawed frog) 463 92.00% ARP48226_P050 Q7ZXC6_XENLA Vim1 protein Xenopus laevis (African clawed frog) 458 85.00% ARP48226_P050 Q7SYN7_XENLA Vim1 protein (Fragment) Xenopus laevis (African clawed frog) 272 85.00% ARP48226_P050 VIM1_XENLA Vimentin‐1/2 Xenopus laevis (African clawed frog) 458 85.00% Ube2j1 ARP43206_T100 A3KMT1_XENLA LOC100049091 protein Xenopus laevis (African clawed frog) 302 92.00% Ordered Locus Names:SGR_2006OrganismStreptomyc es griseus subsp. griseus (strain JCM 4626 / NBRC 13350) ARP49089_T100 Q5PQ95_XENLA LOC495941 protein Xenopus laevis (African clawed frog) 638 78.00% Xenopus tropicalis (Western clawed frog) rsmA ARP34544_T100 B7ZTC1_XENTR Transcription factor B1, mitochondrial (Silurana tropicalis) 346 78.00% Xenopus tropicalis (Western clawed frog) rsmA ARP34544_T100 B1H151_XENTR Tfb1m protein (Silurana tropicalis) 346 78.00% Dimethyladenosine transferase 1, mitochondrial (EC 2.1.1.‐) (Mitochondrial 12S rRNA dimethylase 1) (Mitochondrial transcription factor B1) (mtTFB1) (S‐ adenosylmethionine‐6‐N', N'‐adenosyl(rRNA) Xenopus tropicalis (Western clawed frog) rsmA ARP34544_T100 TFB1M_XENTR dimethyltransferase 1) (Silurana tropicalis) 346 78.00% ARP36556_P050 Q68F43_XENLA MGC81814 protein Xenopus laevis (African clawed frog) 181 91.00% Xenopus tropicalis (Western clawed frog) Tmem48 ARP46268_P050 Q05AS0_XENTR Transmembrane protein 48 (Silurana tropicalis) 664 100.00% Nucleoporin NDC1 (xNDC1) (Transmembrane Tmem48 ARP46268_P050 NDC1_XENLA protein 48) Xenopus laevis (African clawed frog) 660 100.00% ORF Names:GSPATT00026867001 EMBL CAK94543.1OrganismParamecium tetraurelia ARP58642_P050 MVP_XENLA Major vault protein (MVP) Xenopus laevis (African clawed frog) 849 92.00% ORF Names:GSPATT00026867001 EMBL CAK94543.1OrganismParamecium Xenopus tropicalis (Western clawed frog) tetraurelia ARP58642_P050 Q0IIZ9_XENTR Putative uncharacterized protein MGC145641 (Silurana tropicalis) 849 100.00% Xenopus tropicalis (Western clawed frog) fat ARP49348_P050 Q0D2E1_XENTR Protocadherin 10 (Silurana tropicalis) 1009 91.00% kbtbd10 ARP38733_T100 Q7ZY68_XENLA LOC398449 protein (Fragment) Xenopus laevis (African clawed frog) 630 85.00% Kelch repeat and BTB (POZ) domain Xenopus tropicalis (Western clawed frog) kbtbd10 ARP38733_T100 Q6P4N4_XENTR containing 10 (Silurana tropicalis) 606 85.00% kbtbd10 ARP38733_T100 Q5XGR1_XENLA LOC495161 protein Xenopus laevis (African clawed frog) 606 85.00% kbtbd10 ARP38733_T100 A1L2H1_XENLA LOC398449 protein Xenopus laevis (African clawed frog) 606 85.00% Protein kinase‐like protein SgK196 (Sugen SGK196 ARP50048_P050 SG196_XENLA kinase 196) Xenopus laevis (African clawed frog) 352 85.00%

ORF Names:GSTENG00028676001 EMBL CAG07870.1OrganismTetraodon nigroviridis (Green puffer) ARP34033_P050 Q6PF78_XENLA Kif2‐A‐prov protein Xenopus laevis (African clawed frog) 686 100.00% ORF Names:GSTENG00028676001 EMBL CAG07870.1OrganismTetraodon nigroviridis (Green puffer) ARP34033_P050 Q6GPC7_XENLA MGC80500 protein Xenopus laevis (African clawed frog) 662 100.00%

ORF Names:GSTENG00028676001 EMBL CAG07870.1OrganismTetraodon nigroviridis (Green puffer) ARP34033_P050 Q5XG61_XENLA MGC80500 protein (Fragment) Xenopus laevis (African clawed frog) 292 100.00%

ORF Names:GSTENG00028676001 EMBL CAG07870.1OrganismTetraodon Kinesin‐like protein KIF2A (Kinesin‐related nigroviridis (Green puffer) ARP34033_P050 KIF2A_XENLA protein xKIF2) Xenopus laevis (African clawed frog) 682 100.00%

ORF Names:v1g234206OrganismNematostel Metallophosphoesterase 1 (EC 3.1.‐.‐) (Post‐ la vectensis (Starlet sea anemone) ARP49781_P050 MPPE1_XENLA GPI attachment to factor 5) Xenopus laevis (African clawed frog) 405 78.00% trim55 ARP43372_P050 Q6INV6_XENLA MGC80214 protein Xenopus laevis (African clawed frog) 360 100.00% trim55 ARP43372_P050 A1L2R6_XENLA LOC100036929 protein Xenopus laevis (African clawed frog) 498 100.00% trim55 ARP43372_P050 Q6DE39_XENLA Rnf30‐prov protein Xenopus laevis (African clawed frog) 356 92.00% Xenopus tropicalis (Western clawed frog) trim55 ARP43372_P050 Q0D2A2_XENTR Tripartite motif‐containing 63 (Silurana tropicalis) 348 92.00% trim55 ARP43372_P050 A1L2S7_XENLA LOC100036938 protein Xenopus laevis (African clawed frog) 356 92.00% Xenopus tropicalis (Western clawed frog) puf60a ARP40760_T100 B0BMQ2_XENTR LOC100145091 protein (Silurana tropicalis) 507 100.00% Xenopus tropicalis (Western clawed frog) Pbk ARP48842_P050 Q5M7R0_XENTR PDZ binding kinase (Silurana tropicalis) 325 100.00% Pbk ARP48842_P050 Q5HZP5_XENLA LOC496340 protein Xenopus laevis (African clawed frog) 325 100.00% hsp10 ARP54651_P050 Q6NUG0_XENLA MGC79030 protein Xenopus laevis (African clawed frog) 102 92.00% Xenopus tropicalis (Western clawed frog) hsp10 ARP54651_P050 Q6DDD2_XENTR Heat shock 10kDa protein 1 (Chaperonin 10) (Silurana tropicalis) 102 92.00% LMAN1 ARP46613_P050 A1L3M9_XENLA Lman1‐a protein Xenopus laevis (African clawed frog) 509 92.00% Xenopus tropicalis (Western clawed frog) csnk1g3 ARP37531_T100 Q6GL54_XENTR , gamma 1 (Silurana tropicalis) 451 78.00% Xenopus tropicalis (Western clawed frog) csnk1g3 ARP37531_T100 Q3LS18_XENTR Casein kinase 1 gamma 2 (Silurana tropicalis) 460 78.00% Casein kinase I isoform gamma‐1 (CKI‐gamma csnk1g3 ARP37531_T100 KC1G1_XENLA 1) (EC 2.7.11.1) Xenopus laevis (African clawed frog) 460 78.00% csnk1g3 ARP37531_T100 Q5EAV0_XENLA MGC85146 protein Xenopus laevis (African clawed frog) 424 78.00% Xenopus tropicalis (Western clawed frog) csnk1g3 ARP37531_T100 B6ID06_XENTR Putative uncharacterized protein (Silurana tropicalis) 416 78.00% csnk1g3 ARP37531_T100 A1L1H1_XENLA LOC100036840 protein Xenopus laevis (African clawed frog) 424 78.00% Xenopus tropicalis (Western clawed frog) csnk1g3 ARP37531_T100 B4F6S2_XENTR Putative uncharacterized protein (Silurana tropicalis) 410 84.00% csnk1g3 ARP37531_T100 Q6GN14_XENLA MGC83646 protein Xenopus laevis (African clawed frog) 412 76.00% Xenopus tropicalis (Western clawed frog) csnk1g3 ARP37531_T100 Q5FW24_XENTR Casein kinase 1, gamma 2 (Silurana tropicalis) 375 76.00% PDE3B ARP44359_P050 Q5PPQ8_XENLA LOC496104 protein Xenopus laevis (African clawed frog) 985 78.00%

Ubiquitin‐conjugating enzyme E2E 1 (UBC4/5 homolog) (Ubiquitin‐conjugating enzyme E2E Xenopus tropicalis (Western clawed frog) 4930524E20Rik ARP43012_P050 Q6P837_XENTR 1 (UBC4/5 homolog, yeast)) (Silurana tropicalis) 200 100.00% 4930524E20Rik ARP43012_P050 Q6DD28_XENLA Ube2e2 protein Xenopus laevis (African clawed frog) 206 100.00% 4930524E20Rik ARP43012_P050 Q6DCS4_XENLA LOC494592 protein Xenopus laevis (African clawed frog) 202 100.00% 4930524E20Rik ARP43012_P050 Q76EZ1_XENLA Ubiquitin conjugating enzyme E2 Xenopus laevis (African clawed frog) 259 92.00% MGC81343 protein (Ubiquitin‐conjugating 4930524E20Rik ARP43012_P050 Q6WKX0_XENLA enzyme UBE2E3) Xenopus laevis (African clawed frog) 207 92.00%

Ubiquitin‐conjugating enzyme E2E 3 (UBC4/5 homolog) (Ubiquitin‐conjugating enzyme E2E Xenopus tropicalis (Western clawed frog) 4930524E20Rik ARP43012_P050 Q6P318_XENTR 3 (UBC4/5 homolog, yeast)) (Silurana tropicalis) 207 92.00% 4930524E20Rik ARP43012_P050 Q63ZS2_XENLA LOC494742 protein Xenopus laevis (African clawed frog) 201 92.00% 4930524E20Rik ARP43012_P050 Q63ZH5_XENLA LOC494805 protein Xenopus laevis (African clawed frog) 201 92.00% Xenopus tropicalis (Western clawed frog) 4930524E20Rik ARP43012_P050 B0BM03_XENTR Ube2e2 protein (Silurana tropicalis) 201 92.00% 4930524E20Rik ARP43012_P050 A9JS12_XENLA Ubiquitin conjugating enzyme E2 Xenopus laevis (African clawed frog) 259 92.00% 4930524E20Rik ARP43012_P050 Q6AZI4_XENLA LOC446231 protein (Fragment) Xenopus laevis (African clawed frog) 153 84.00% Xenopus tropicalis (Western clawed frog) 4930524E20Rik ARP43012_P050 Q5BJ50_XENTR Ubiquitin‐conjugating enzyme E2L 3 (Silurana tropicalis) 154 84.00% 4930524E20Rik ARP43012_P050 Q4QR35_XENLA LOC446231 protein Xenopus laevis (African clawed frog) 154 84.00% Xenopus tropicalis (Western clawed frog) Chit1 ARP42601_P050 Q6DJ52_XENTR Chitinase 1 (Chitotriosidase) (Silurana tropicalis) 492 92.00% Xenopus tropicalis (Western clawed frog) Chit1 ARP42601_P050 Q5CZZ2_XENTR Chia‐prov protein (Fragment) (Silurana tropicalis) 479 92.00% Chit1 ARP42601_P050 Q6GP67_XENLA MGC80644 protein Xenopus laevis (African clawed frog) 489 92.00% Xenopus tropicalis (Western clawed frog) Car8 ARP42166_T100 Q5M8Z5_XENTR Carbonic anhydrase VIII (Silurana tropicalis) 282 84.00% Xenopus tropicalis (Western clawed frog) SC4MOL ARP46773_T100 Q0V9N6_XENTR Sterol‐C4‐methyl oxidase‐like (Silurana tropicalis) 294 76.00%

ORF Names:AGAP002545OrganismAnophel es gambiae (African malaria mosquito) ARP39466_T100 Q7ZXI7_XENLA Nr2f2 protein Xenopus laevis (African clawed frog) 405 100.00%

ORF Names:AGAP002545OrganismAnophel Xenopus tropicalis (Western clawed frog) es gambiae (African malaria mosquito) ARP39466_T100 A9ULC1_XENTR Nr2f2 protein (Silurana tropicalis) 408 100.00% ORF Names:AGAP002545OrganismAnophel es gambiae (African malaria mosquito) ARP39466_T100 Q91720_XENLA Coup transcription factor Xenopus laevis (African clawed frog) 397 92.00%

ORF Names:AGAP002545OrganismAnophel es gambiae (African malaria mosquito) ARP39466_T100 Q9W745_XENLA COUP transcription factor 1 Xenopus laevis (African clawed frog) 411 92.00%

ORF Names:AGAP002545OrganismAnophel es gambiae (African malaria mosquito) ARP39466_T100 Q6DCH6_XENLA Nr2f2 protein Xenopus laevis (African clawed frog) 404 92.00%

ORF Names:AGAP002545OrganismAnophel Xenopus tropicalis (Western clawed frog) es gambiae (African malaria mosquito) ARP39466_T100 A4QNF4_XENTR Nr2f1 protein (Silurana tropicalis) 410 92.00%

ORF Names:AGAP002545OrganismAnophel es gambiae (African malaria mosquito) ARP39466_T100 Q7T0T7_XENLA Nr2f6 protein Xenopus laevis (African clawed frog) 389 78.00%

ORF Names:AGAP002545OrganismAnophel Nuclear receptor subfamily 2, group F, Xenopus tropicalis (Western clawed frog) es gambiae (African malaria mosquito) ARP39466_T100 Q6GL59_XENTR member 6 (Silurana tropicalis) 389 78.00% CBLN4 ARP52505_P050 Q6PGS2_XENLA MGC64424 protein Xenopus laevis (African clawed frog) 205 100.00% Xenopus tropicalis (Western clawed frog) CBLN4 ARP52505_P050 A9UMQ8_XENTR LOC100124953 protein (Silurana tropicalis) 200 100.00% Xenopus tropicalis (Western clawed frog) CBLN4 ARP52505_P050 A4II59_XENTR LOC100124953 protein (Fragment) (Silurana tropicalis) 248 100.00% CBLN4 ARP52505_P050 Q7SYY6_XENLA Cbln2‐prov protein Xenopus laevis (African clawed frog) 218 85.00% CBLN4 ARP52505_P050 Q6GM40_XENLA MGC83990 protein Xenopus laevis (African clawed frog) 215 85.00% CBLN4 ARP52505_P050 Q5PQA2_XENLA LOC495934 protein Xenopus laevis (African clawed frog) 191 85.00% Xenopus tropicalis (Western clawed frog) CBLN4 ARP52505_P050 Q0V9W9_XENTR Putative uncharacterized protein MGC145915 (Silurana tropicalis) 191 85.00% Xenopus tropicalis (Western clawed frog) CBLN4 ARP52505_P050 A7MC51_XENTR LOC100127549 protein (Silurana tropicalis) 222 85.00% Slc25a39 ARP43962_P050 Q6GP92_XENLA MGC80594 protein Xenopus laevis (African clawed frog) 356 84.00% Xenopus tropicalis (Western clawed frog) Slc25a39 ARP43962_P050 Q5M8E2_XENTR LOC496786 protein (Fragment) (Silurana tropicalis) 362 84.00% Slc25a39 ARP43962_P050 Q3KPS7_XENLA MGC131348 protein Xenopus laevis (African clawed frog) 356 84.00% Xenopus tropicalis (Western clawed frog) Slc25a39 ARP43962_P050 A4IIA1_XENTR Hypothetical LOC496786 (LOC496786 protein) (Silurana tropicalis) 356 84.00% Xenopus tropicalis (Western clawed frog) Scrn2 ARP58525_P050 SCRN2_XENTR Secernin‐2 (Silurana tropicalis) 446 92.00% Scrn2 ARP58525_P050 SCRN2_XENLA Secernin‐2 Xenopus laevis (African clawed frog) 428 92.00% Scrn2 ARP58525_P050 Q6GLL9_XENLA MGC84738 protein Xenopus laevis (African clawed frog) 407 92.00% Scrn2 ARP58525_P050 A8WH61_XENLA LOC100127266 protein Xenopus laevis (African clawed frog) 409 85.00% Xenopus tropicalis (Western clawed frog) MEIS3P1 ARP36223_P050 A0JPD2_XENTR Meis2 protein (Silurana tropicalis) 368 100.00% MEIS3P1 ARP36223_P050 MEI3A_XENLA Isoform 2 Xenopus laevis (African clawed frog) 385 92.00% Xenopus tropicalis (Western clawed frog) MEIS3P1 ARP36223_P050 MEIS3_XENTR Homeobox protein meis3 (Silurana tropicalis) 453 92.00% MEIS3P1 ARP36223_P050 MEI3B_XENLA Homeobox protein meis3‐B Xenopus laevis (African clawed frog) 451 92.00% MEIS3P1 ARP36223_P050 MEI3A_XENLA Homeobox protein meis3‐A (XMeis3) Xenopus laevis (African clawed frog) 453 92.00% MEIS3P1 ARP36223_P050 B7ZRS8_XENLA Meis1 protein Xenopus laevis (African clawed frog) 465 85.00% MEIS3P1 ARP36223_P050 MEIS1_XENLA Isoform 2 (Isoform XMeis1‐2) (Isoform b) Xenopus laevis (African clawed frog) 465 85.00% MEIS3P1 ARP36223_P050 MEIS1_XENLA Homeobox protein Meis1 (XMeis1) Xenopus laevis (African clawed frog) 390 85.00% Xenopus tropicalis (Western clawed frog) st6galnac5 ARP49986_T100 A4IGK6_XENTR Putative uncharacterized protein (Silurana tropicalis) 313 85.00% Alpha‐2,6‐sialyltransferase ST6GalNAc V Xenopus tropicalis (Western clawed frog) st6galnac5 ARP49986_T100 Q6ZXY3_XENTR (Fragment) (Silurana tropicalis) 313 78.00% Xenopus tropicalis (Western clawed frog) st6galnac5 ARP49986_T100 D2U4U3_XENTR Alpha‐2,6‐sialyltransferase ST6GalNAc VI (Silurana tropicalis) 306 76.00% Xenopus tropicalis (Western clawed frog) 6330527O06Rik ARP46875_P050 CT103_XENTR LAMP family protein C20orf103 homolog (Silurana tropicalis) 276 78.00%

SMC2 ARP46043_P050 A2RVA9_XENLA Putative uncharacterized protein (Fragment) Xenopus laevis (African clawed frog) 466 92.00% Structural maintenance of chromosomes protein 2 (SMC protein 2) (SMC‐2) (Chromosome assembly protein XCAP‐E) SMC2 ARP46043_P050 SMC2_XENLA (Chromosome‐associated protein E) Xenopus laevis (African clawed frog) 1203 92.00% uqcr10 ARP44448_P050 A9UM09_XENLA LOC100137668 protein Xenopus laevis (African clawed frog) 62 84.00% Ubiquinol‐cytochrome c reductase complex Xenopus tropicalis (Western clawed frog) uqcr10 ARP44448_P050 Q28ID4_XENTR (7.2 kD) (Ucrc) (Silurana tropicalis) 62 84.00% ARP45276_T100 Q7SYR7_XENLA LOC398643 protein (Fragment) Xenopus laevis (African clawed frog) 360 85.00% Xenopus tropicalis (Western clawed frog) ARP45276_T100 Q0IHL6_XENTR LOC100038258 protein (Silurana tropicalis) 348 85.00% Xenopus tropicalis (Western clawed frog) ARP45276_T100 B0JYU6_XENTR LOC100038258 protein (Fragment) (Silurana tropicalis) 347 85.00% AMFR2 ARP42995_T100 Q6PAF9_XENLA MGC68459 protein Xenopus laevis (African clawed frog) 636 92.00% AMFR2 ARP42995_T100 Q6IP55_XENLA MGC78940 protein Xenopus laevis (African clawed frog) 635 92.00% Xenopus tropicalis (Western clawed frog) AMFR2 ARP42995_T100 Q28GC0_XENTR Autocrine motility factor receptor (Silurana tropicalis) 635 92.00% ORF Names:TRIADDRAFT_19868 EMBL EDV29590.1OrganismTrichoplax adhaerens (Trichoplax reptans) ARP50821_P050 B1H1U1_XENLA LOC100158306 protein Xenopus laevis (African clawed frog) 562 92.00% Xenopus tropicalis (Western clawed frog) ARP37995_P050 Q0EDH7_XENTR Thyroid hormone receptor beta (Silurana tropicalis) 383 78.00% Xenopus tropicalis (Western clawed frog) ARP37995_P050 B3GR08_XENTR Thyroid hormone receptor beta (Silurana tropicalis) 383 78.00% ARP37995_P050 THBB_XENLA Isoform Beta‐B1 (Isoform BetaB‐I) Xenopus laevis (African clawed frog) 374 78.00% ARP37995_P050 THBA_XENLA Isoform Beta‐A1 (Isoform BetaA‐I) Xenopus laevis (African clawed frog) 369 78.00% Thyroid hormone receptor beta‐B (TRbetaB) (Nuclear receptor subfamily 1 group A ARP37995_P050 THBB_XENLA member 2‐B) Xenopus laevis (African clawed frog) 414 78.00% Thyroid hormone receptor beta‐A (TRbetaA) (xTR) (Nuclear receptor subfamily 1 group A ARP37995_P050 THBA_XENLA member 2‐A) Xenopus laevis (African clawed frog) 373 78.00% Actin related protein 2/3 complex, subunit 2, Xenopus tropicalis (Western clawed frog) ARP58587_P050 Q6GL82_XENTR 34kDa (Silurana tropicalis) 299 100.00% Actin‐related protein 2/3 complex subunit 2 ARP58587_P050 Q0IH88_XENLA (MGC154528 protein) Xenopus laevis (African clawed frog) 300 100.00% ARP58587_P050 Q6IRB1_XENLA MGC78865 protein Xenopus laevis (African clawed frog) 300 92.00% E3 ubiquitin‐protein ligase RNF168 (EC 6.3.2.‐) Rnf168 ARP43433_P050 RN168_XENLA (RING finger protein 168) Xenopus laevis (African clawed frog) 557 78.00% FGG ARP44300_T100 Q7SZ13_XENLA Fgg protein Xenopus laevis (African clawed frog) 439 92.00% FGG ARP44300_T100 FIBG_XENLA Fibrinogen gamma chain Xenopus laevis (African clawed frog) 438 92.00% Xenopus tropicalis (Western clawed frog) klhdc1 ARP53220_P050 A9UMK6_XENTR LOC100135383 protein (Silurana tropicalis) 142 85.00%

Histone‐lysine N‐methyltransferase SUV39H1 (EC 2.1.1.43) (Suppressor of variegation 3‐9 Suv39h1 ARP32470_T100 SUV91_XENLA homolog 1) (Su(var)3‐9 homolog 1) Xenopus laevis (African clawed frog) 421 85.00%

ORF Names:v1g98639OrganismNematostell Xenopus tropicalis (Western clawed frog) a vectensis (Starlet sea anemone) ARP50977_P050 B4F6S1_XENTR Putative uncharacterized protein (Silurana tropicalis) 337 83.00%

ORF Names:v1g98639OrganismNematostell a vectensis (Starlet sea anemone) ARP50977_P050 Q6AX11_XENLA Znf420 protein Xenopus laevis (African clawed frog) 980 90.00% Xenopus tropicalis (Western clawed frog) MYB ARP32028_P050 Q4VBE3_XENTR Myb protein (Fragment) (Silurana tropicalis) 759 90.00% MYB ARP32028_P050 MYB_XENLA Transcriptional activator Myb Xenopus laevis (African clawed frog) 624 81.00% ORF Names:v1g187332OrganismNematostel Xenopus tropicalis (Western clawed frog) la vectensis (Starlet sea anemone) ARP42814_P050 B0JZ54_XENTR Foxb1 protein (Silurana tropicalis) 322 100.00%

ORF Forkhead box protein B2 (FoxB2) (xFoxB2) Names:v1g187332OrganismNematostel (Fork head domain‐related protein 5) (FD‐5) la vectensis (Starlet sea anemone) ARP42814_P050 FOXB2_XENLA (xFD‐5) Xenopus laevis (African clawed frog) 317 100.00%

ORF Names:v1g187332OrganismNematostel Forkhead box protein B1 (FoxB1) la vectensis (Starlet sea anemone) ARP42814_P050 FOXB1_XENLA (Transcription factor FKH‐5) Xenopus laevis (African clawed frog) 319 100.00%

ORF Names:v1g187332OrganismNematostel la vectensis (Starlet sea anemone) ARP42814_P050 B7ZQH6_XENLA FoxE5 Xenopus laevis (African clawed frog) 379 78.00%

ORF Names:v1g187332OrganismNematostel la vectensis (Starlet sea anemone) ARP42814_P050 FOXE1_XENLA Forkhead box protein E1 (FoxE1) Xenopus laevis (African clawed frog) 379 78.00% Xenopus tropicalis (Western clawed frog) Racgap1 ARP31905_T100 Q6NVL1_XENTR Rac GTPase activating protein 1 (Silurana tropicalis) 629 85.00% Racgap1 ARP31905_T100 Q6NRH9_XENLA MGC83804 protein Xenopus laevis (African clawed frog) 629 85.00% Racgap1 ARP31905_T100 Q7ZWW6_XENLA MGC53048 protein Xenopus laevis (African clawed frog) 629 78.00%

ORF Names:CHLREDRAFT_118990 EMBL EDP01710.1OrganismChlamydomonas Xenopus tropicalis (Western clawed frog) reinhardtii (Chlamydomonas smithii) ARP36479_T100 B1H117_XENTR Ddx55 protein (Silurana tropicalis) 594 76.00%

ORF Names:CHLREDRAFT_118990 EMBL EDP01710.1OrganismChlamydomonas ATP‐dependent RNA helicase DDX55 (EC reinhardtii (Chlamydomonas smithii) ARP36479_T100 DDX55_XENLA 3.6.4.13) (DEAD box protein 55) Xenopus laevis (African clawed frog) 594 76.00% Xenopus tropicalis (Western clawed frog) ARP53122_P050 Q6DJA0_XENTR MGC88919 protein (Silurana tropicalis) 276 100.00% Xenopus tropicalis (Western clawed frog) ARP53122_P050 Q28DA2_XENTR Novel protein (Silurana tropicalis) 275 100.00% ARP53122_P050 Q6P424_XENLA MGC68627 protein Xenopus laevis (African clawed frog) 275 92.00% Acot11 ARP52535_P050 Q6GM80_XENLA MGC82100 protein Xenopus laevis (African clawed frog) 577 100.00% Xenopus tropicalis (Western clawed frog) Acot11 ARP52535_P050 B5DFR9_XENTR LOC100170471 protein (Silurana tropicalis) 580 100.00% Xenopus tropicalis (Western clawed frog) Acot11 ARP52535_P050 B3DLA1_XENTR LOC100170471 protein (Silurana tropicalis) 476 100.00% Acot11 ARP52535_P050 A9UM00_XENLA LOC100137660 protein Xenopus laevis (African clawed frog) 425 78.00% ORF Names:GSPATT00012964001 EMBL CAK77479.1OrganismParamecium Xenopus tropicalis (Western clawed frog) tetraurelia ARP47232_P050 Q5XGI9_XENTR Hypothetical LOC496479 (Silurana tropicalis) 683 78.00% ORF Names:GSPATT00012964001 EMBL CAK77479.1OrganismParamecium tetraurelia ARP47232_P050 Q7ZTQ2_XENLA Facl2 protein (Facl2‐prov protein) Xenopus laevis (African clawed frog) 698 78.00% ORF Names:GSPATT00012964001 EMBL CAK77479.1OrganismParamecium tetraurelia ARP47232_P050 Q7ZTJ3_XENLA MGC53832 protein Xenopus laevis (African clawed frog) 698 78.00% ORF Names:ACLA_095310 EMBL EAW08598.1OrganismAspergillus Trafficking protein particle complex 6A Xenopus tropicalis (Western clawed frog) clavatus ARP53348_P050 Q6NVQ4_XENTR (Trafficking protein particle complex 6B) (Silurana tropicalis) 158 100.00% ORF Names:ACLA_095310 EMBL EAW08598.1OrganismAspergillus Xenopus tropicalis (Western clawed frog) clavatus ARP53348_P050 Q0IJ18_XENTR LOC779535 protein (Fragment) (Silurana tropicalis) 142 100.00% ORF Names:ACLA_095310 EMBL EAW08598.1OrganismAspergillus clavatus ARP53348_P050 Q7ZXX6_XENLA MGC52668 protein Xenopus laevis (African clawed frog) 158 92.00%

ORF Names:v1g179634OrganismNematostel Der1‐like domain family, member 3derlin‐3 Xenopus tropicalis (Western clawed frog) la vectensis (Starlet sea anemone) ARP44443_P050 Q28F56_XENTR (Putative uncharacterized protein LOC548851) (Silurana tropicalis) 239 92.00% Xenopus tropicalis (Western clawed frog) ARP48555_P050 A9JTS3_XENTR LOC100127839 protein (Silurana tropicalis) 223 78.00% Glutathione S‐transferase A4 (Putative Xenopus tropicalis (Western clawed frog) ARP48555_P050 Q28IT9_XENTR uncharacterized protein LOC549430) (Silurana tropicalis) 233 78.00% Xenopus tropicalis (Western clawed frog) ARP48555_P050 B4F6L2_XENTR Putative uncharacterized protein (Silurana tropicalis) 189 78.00%

tRNA (guanine‐N(7)‐)‐methyltransferase (EC 2.1.1.33) (Methyltransferase‐like protein 1) trm8 ARP48665_T100 TRMB_XENLA (tRNA(m7G46)‐methyltransferase) Xenopus laevis (African clawed frog) 273 92.00%

tRNA (guanine‐N(7)‐)‐methyltransferase B (EC 2.1.1.33) (Methyltransferase‐like protein 1 B) Xenopus tropicalis (Western clawed frog) trm8 ARP48665_T100 TRMBB_XENTR (tRNA(m7G46)‐methyltransferase B) (Silurana tropicalis) 241 92.00% tRNA (guanine‐N(7)‐)‐methyltransferase A (EC 2.1.1.33) (Methyltransferase‐like protein 1 A) Xenopus tropicalis (Western clawed frog) trm8 ARP48665_T100 TRMBA_XENTR (tRNA(m7G46)‐methyltransferase A) (Silurana tropicalis) 273 92.00% Gtf2h4 ARP32598_P050 Q6INF9_XENLA MGC83106 protein Xenopus laevis (African clawed frog) 455 84.00% ARP35045_T100 Q6GLV9_XENLA MGC84171 protein Xenopus laevis (African clawed frog) 240 78.00% Xenopus tropicalis (Western clawed frog) ARP35045_T100 Q6DJ51_XENTR CLIC3 protein (Fragment) (Silurana tropicalis) 266 78.00% Xenopus tropicalis (Western clawed frog) ARP35045_T100 Q0IIS9_XENTR CLIC3 protein (Fragment) (Silurana tropicalis) 256 78.00% Xenopus tropicalis (Western clawed frog) nr5a1 ARP37471_T100 B9WZB5_XENTR Steroidgenic factor 1 (Silurana tropicalis) 468 78.00% nr5a1 ARP37471_T100 A4PCW0_XENLA Xenopus laevis (African clawed frog) 468 78.00% Xenopus tropicalis (Western clawed frog) PRDM9 ARP39611_T100 Q6P337_XENTR Zinc finger protein 668 (Silurana tropicalis) 550 78.00% PRDM9 ARP39611_T100 Q6INL8_XENLA MGC82378 protein Xenopus laevis (African clawed frog) 545 78.00% PRDM9 ARP39611_T100 Q63ZH1_XENLA LOC494807 protein Xenopus laevis (African clawed frog) 545 78.00% C1qtnf7 ARP52426_P050 Q66KH7_XENLA MGC82006 protein Xenopus laevis (African clawed frog) 1131 84.00% LOC398610 ARP42370_P050 Q7T3S0_XENLA PP2A B'' subunit PR130 Xenopus laevis (African clawed frog) 1127 76.00% LOC398610 ARP42370_P050 A1L2R4_XENLA Putative uncharacterized protein Xenopus laevis (African clawed frog) 519 76.00% LOC398610 ARP42370_P050 Q7T3S1_XENLA PP2A B'' subunit PR48 Xenopus laevis (African clawed frog) 565 83.00% Xenopus tropicalis (Western clawed frog) LOC398610 ARP42370_P050 Q08D09_XENTR Putative uncharacterized protein MGC147395 (Silurana tropicalis) 569 83.00% LOC398610 ARP42370_P050 A1A5J1_XENLA LOC398610 protein Xenopus laevis (African clawed frog) 565 83.00% LOC398610 ARP42370_P050 Q498G0_XENLA LOC734216 protein (Fragment) Xenopus laevis (African clawed frog) 435 75.00% Xenopus tropicalis (Western clawed frog) RHPN2 ARP52450_P050 Q66IJ8_XENTR Rhpn1 protein (Silurana tropicalis) 706 85.00% LOC100145690 protein (Putative Xenopus tropicalis (Western clawed frog) RHPN2 ARP52450_P050 B1WAP5_XENTR uncharacterized protein LOC100145690) (Silurana tropicalis) 682 76.00%

RHPN2 ARP52450_P050 RHN2A_XENLA Rhophilin‐2‐A (GTP‐Rho‐binding protein 2‐A) Xenopus laevis (African clawed frog) 683 76.00% ARP40987_T100 MTHSD_XENLA Isoform 2 Xenopus laevis (African clawed frog) 415 78.00% Methenyltetrahydrofolate synthase domain‐ ARP40987_T100 MTHSD_XENLA containing protein Xenopus laevis (African clawed frog) 415 78.00% sec23 ARP52162_P050 Q6DJE0_XENLA MGC84454 protein Xenopus laevis (African clawed frog) 741 100.00% Xenopus tropicalis (Western clawed frog) sec23 ARP52162_P050 Q5BKK9_XENTR SEC23B (S. cerevisiae) (Silurana tropicalis) 767 100.00% Xenopus tropicalis (Western clawed frog) sec23 ARP52162_P050 Q28GB1_XENTR Sec23 homolog B (S. cerevisiae) (Fragment) (Silurana tropicalis) 396 100.00% Xenopus tropicalis (Western clawed frog) sec23 ARP52162_P050 Q28DM5_XENTR Sec23 homolog B (S. cerevisiae) (Silurana tropicalis) 767 100.00% sec23 ARP52162_P050 A3KMU3_XENLA Putative uncharacterized protein (Fragment) Xenopus laevis (African clawed frog) 259 100.00% Protein transport protein Sec23A (SEC23‐ Xenopus tropicalis (Western clawed frog) sec23 ARP52162_P050 SC23A_XENTR related protein A) (Silurana tropicalis) 765 100.00% ORF Names:PITG_02122 EMBL EEY63656.1OrganismPhytophthora infestans T30‐4 ARP48990_P050 Q9I8M2_XENLA Putative N‐terminal acetyltransferase Xenopus laevis (African clawed frog) 846 92.00% ORF Names:PITG_02122 EMBL EEY63656.1OrganismPhytophthora Xenopus tropicalis (Western clawed frog) infestans T30‐4 ARP48990_P050 B3DLA3_XENTR Putative uncharacterized protein (Silurana tropicalis) 864 92.00% ORF Names:PITG_02122 EMBL EEY63656.1OrganismPhytophthora NMDA receptor regulated 1‐like (Narg1l infestans T30‐4 ARP48990_P050 A8WH35_XENLA protein) Xenopus laevis (African clawed frog) 864 92.00% ORF Names:PITG_02122 EMBL EEY63656.1OrganismPhytophthora infestans T30‐4 ARP48990_P050 A0JMW5_XENLA Narg1l protein (Fragment) Xenopus laevis (African clawed frog) 619 92.00% P100814_P050 RUNX1_XENLA Isoform 2 Xenopus laevis (African clawed frog) 476 75.00%

Runt‐related transcription factor 1 (Acute myeloid leukemia 1 protein) (XAML) (Core‐ P100814_P050 RUNX1_XENLA binding factor subunit alpha‐2) (CBF‐alpha‐2) Xenopus laevis (African clawed frog) 462 75.00% P100685_P050 Q6DCX0_XENLA Vav1‐prov protein Xenopus laevis (African clawed frog) 845 84.00% ARP34429_T100 Q4V7Y6_XENLA MGC114919 protein Xenopus laevis (African clawed frog) 299 92.00% Upstream stimulatory factor 1 (USF) (B1 usf1 ARP34429_T100 USF1_XENBO factor) (SPF1) Xenopus borealis (Kenyan clawed frog) 307 92.00% Xenopus tropicalis (Western clawed frog) usf1 ARP34429_T100 A4IH39_XENTR Usf1 protein (Silurana tropicalis) 309 85.00% Cleavage and polyadenylation specific factor Xenopus tropicalis (Western clawed frog) LOC548671 ARP40697_T100 Q28CF7_XENTR 6, 68kDa (Silurana tropicalis) 547 78.00% Xenopus tropicalis (Western clawed frog) LOC548671 ARP40697_T100 B4F6K8_XENTR Putative uncharacterized protein LOC548671 (Silurana tropicalis) 547 78.00% Xenopus tropicalis (Western clawed frog) clvs1 ARP53266_P050 A4IGW0_XENTR LOC100037913 protein (Silurana tropicalis) 135 100.00% Clavesin‐1 (Retinaldehyde‐binding protein 1‐ clvs1 ARP53266_P050 CLVS1_XENLA like 1) Xenopus laevis (African clawed frog) 332 100.00% Ckmt1 ARP41478_T100 Q7ZY21_XENLA MGC53985 protein Xenopus laevis (African clawed frog) 419 78.00% Ckmt1 ARP41478_T100 Q7ZX84_XENLA Ckmt1‐prov protein Xenopus laevis (African clawed frog) 418 78.00% Creatine kinase, mitochondrial 1 (Creatine Xenopus tropicalis (Western clawed frog) Ckmt1 ARP41478_T100 Q6P310_XENTR kinase, mitochondrial 1B) (Silurana tropicalis) 417 78.00% ARP44325_P050 Q9DGK9_XENLA Na/K ATPase beta subunit (EC 3.6.1.37) Xenopus laevis (African clawed frog) 300 83.00% ARP44325_P050 Q9DEN5_XENLA Na,K‐ATPase beta‐2 subunit (EC 3.6.1.37) Xenopus laevis (African clawed frog) 300 83.00% ARP44325_P050 Q7ZX09_XENLA Atp1b2 protein Xenopus laevis (African clawed frog) 300 83.00%

DEF6 ARP46214_T100 DEFI6_XENLA Differentially expressed in FDCP 6 homolog Xenopus laevis (African clawed frog) 596 85.00% Xenopus tropicalis (Western clawed frog) ARP40329_T100 Q28D24_XENTR Ribosomal protein S29 (Silurana tropicalis) 56 100.00% ARP40329_T100 Q4QR32_XENLA MGC114875 protein Xenopus laevis (African clawed frog) 56 92.00% Xenopus tropicalis (Western clawed frog) RASGEF1B ARP55737_P050 B1H0X4_XENTR LOC549667 protein (Silurana tropicalis) 472 92.00% Xenopus tropicalis (Western clawed frog) RASGEF1B ARP55737_P050 RGF1B_XENTR Ras‐GEF domain‐containing family member 1B (Silurana tropicalis) 472 92.00% Xenopus tropicalis (Western clawed frog) pnp ARP48474_P050 Q6DIT1_XENTR Nucleoside phosphorylase (Silurana tropicalis) 297 78.00% ARP48639_P050 Q5M9B2_XENLA LOC496144 protein Xenopus laevis (African clawed frog) 255 83.00%

ORF Names:zgc:158653 ZFIN ZDB‐GENE‐ 070112‐502OrganismDanio rerio Xenopus tropicalis (Western clawed frog) (Zebrafish) (Brachydanio rerio) ARP39342_P050 B1H180_XENTR LOC100145315 protein (Silurana tropicalis) 475 100.00% EPAS1 ARP32253_P050 Q6GP97_XENLA MGC80589 protein Xenopus laevis (African clawed frog) 862 100.00% EPAS1 ARP32253_P050 Q6GQ12_XENLA MGC80468 protein Xenopus laevis (African clawed frog) 859 92.00% Xenopus tropicalis (Western clawed frog) EPAS1 ARP32253_P050 Q6GL61_XENTR Endothelial PAS domain protein 1 (Silurana tropicalis) 862 85.00% ORF Names:Bm1_21630 EMBL EDP35386.1OrganismBrugia malayi (Filarial nematode worm) P100962_T100 Q6PHW7_XENLA Tceb1‐prov protein Xenopus laevis (African clawed frog) 112 100.00% ORF Names:Bm1_21630 EMBL EDP35386.1OrganismBrugia malayi Transcription elongation factor B (SIII), Xenopus tropicalis (Western clawed frog) (Filarial nematode worm) P100962_T100 Q28H26_XENTR polypeptide 1 (15kDa, elongin C) (Silurana tropicalis) 112 100.00% Gamma‐aminobutyric acid receptor subunit Gabrr2 ARP35060_P050 E5LEY1_XENLA rho‐1 (Fragment) Xenopus laevis (African clawed frog) 134 92.00% Gamma‐aminobutyric acid receptor subunit Gabrr2 ARP35060_P050 E5LEY3_XENLA rho‐3 (Fragment) Xenopus laevis (African clawed frog) 303 92.00% Srsf12 ARP40671_P050 Q7ZTJ8_XENLA MGC53149 protein Xenopus laevis (African clawed frog) 258 85.00% FUS interacting protein (Serine/arginine‐rich) Xenopus tropicalis (Western clawed frog) Srsf12 ARP40671_P050 Q5XGF2_XENTR 1 (Silurana tropicalis) 258 85.00% FUS interacting protein (Serine/arginine‐rich) Xenopus tropicalis (Western clawed frog) Srsf12 ARP40671_P050 Q28HR7_XENTR 1 (Silurana tropicalis) 257 85.00% Xenopus tropicalis (Western clawed frog) Srsf12 ARP40671_P050 Q66KD3_XENTR Serine‐arginine repressor protein (35 kDa) (Silurana tropicalis) 253 85.00% Srsf12 ARP40671_P050 Q5XH43_XENLA LOC495068 protein Xenopus laevis (African clawed frog) 251 78.00%

Mitochondrial intermembrane space import and assembly protein 40 (Coiled‐coil‐helix‐ Xenopus tropicalis (Western clawed frog) AU015836 ARP51895_P050 MIA40_XENTR coiled‐coil‐helix domain‐containing protein 4) (Silurana tropicalis) 139 100.00% Mitochondrial intermembrane space import and assembly protein 40‐B (Coiled‐coil‐helix‐ coiled‐coil‐helix domain‐containing protein 4‐ AU015836 ARP51895_P050 MI40B_XENLA B) Xenopus laevis (African clawed frog) 139 100.00% Mitochondrial intermembrane space import and assembly protein 40‐A (Coiled‐coil‐helix‐ coiled‐coil‐helix domain‐containing protein 4‐ AU015836 ARP51895_P050 MI40A_XENLA A) Xenopus laevis (African clawed frog) 139 100.00% ORF Names:ACLA_088950 EMBL EAW11204.1OrganismAspergillus clavatus ARP49052_P050 Q3KQ09_XENLA LOC733347 protein (Fragment) Xenopus laevis (African clawed frog) 319 100.00% ORF Names:ACLA_088950 EMBL EAW11204.1OrganismAspergillus clavatus ARP49052_P050 Q0P3S8_XENLA LOC733347 protein (Fragment) Xenopus laevis (African clawed frog) 333 100.00% ORF Names:ACLA_088950 EMBL EAW11204.1OrganismAspergillus Xenopus tropicalis (Western clawed frog) clavatus ARP49052_P050 A4IJ22_XENTR LOC100125105 protein (Silurana tropicalis) 295 100.00% ORF Names:ACLA_088950 EMBL EAW11204.1OrganismAspergillus clavatus ARP49052_P050 A1L2Y4_XENLA LOC100036988 protein (Fragment) Xenopus laevis (African clawed frog) 289 100.00% CHERP ARP40642_P050 Q7ZWT5_XENLA Cherp‐prov protein Xenopus laevis (African clawed frog) 924 100.00% CHERP ARP40642_P050 Q68F05_XENLA MGC83231 protein Xenopus laevis (African clawed frog) 933 100.00% Calcium homeostasis endoplasmic reticulum Xenopus tropicalis (Western clawed frog) CHERP ARP40642_P050 Q5XGE8_XENTR protein (Silurana tropicalis) 944 100.00% ANRA2 ARP50675_P050 Q6NRS9_XENLA MGC81501 protein Xenopus laevis (African clawed frog) 312 100.00% Xenopus tropicalis (Western clawed frog) ANRA2 ARP50675_P050 Q6DIZ3_XENTR Ankyrin repeat, family A (RFXANK‐like), 2 (Silurana tropicalis) 312 100.00% Xenopus tropicalis (Western clawed frog) ARP39144_T100 Q6P1U6_XENTR Tox4 protein (Fragment) (Silurana tropicalis) 232 92.00% Xenopus tropicalis (Western clawed frog) tox4 ARP39144_T100 Q0V9H2_XENTR Putative uncharacterized protein (Fragment) (Silurana tropicalis) 267 92.00% Xenopus tropicalis (Western clawed frog) tox4 ARP39144_T100 TOX4_XENTR TOX high mobility group box family member 4 (Silurana tropicalis) 597 92.00% TOX high mobility group box family member 4‐ tox4 ARP39144_T100 TOX4B_XENLA B Xenopus laevis (African clawed frog) 594 92.00% TOX high mobility group box family member 4‐ tox4 ARP39144_T100 TOX4A_XENLA A Xenopus laevis (African clawed frog) 597 92.00% Xenopus tropicalis (Western clawed frog) tox4 ARP39144_T100 B2GUG5_XENTR LOC100158584 protein (Silurana tropicalis) 580 100.00% Xenopus tropicalis (Western clawed frog) adk ARP46059_T100 KAD2_XENTR Isoform 2 (Silurana tropicalis) 235 92.00% Adenylate kinase 2, mitochondrial (AK 2) (EC Xenopus tropicalis (Western clawed frog) adk ARP46059_T100 KAD2_XENTR 2.7.4.3) (ATP‐AMP transphosphorylase 2) (Silurana tropicalis) 241 92.00%

Adenylate kinase 2, mitochondrial (AK 2) (EC adk ARP46059_T100 KAD2_XENLA 2.7.4.3) (ATP‐AMP transphosphorylase 2) Xenopus laevis (African clawed frog) 241 92.00% ORF Names:NFIA_109330 EMBL EAW25439.1OrganismNeosartorya fischeri (strain ATCC 1020 / DSM 3700 / FGSC A1164 / NRRL 181) (Aspergillus fischerianus) ARP35374_P050 Q802C6_XENLA MGC53422 protein Xenopus laevis (African clawed frog) 355 76.00% ORF Names:NFIA_109330 EMBL EAW25439.1OrganismNeosartorya fischeri (strain ATCC 1020 / DSM 3700 / FGSC A1164 / NRRL 181) (Aspergillus Xenopus tropicalis (Western clawed frog) fischerianus) ARP35374_P050 Q28FD5_XENTR OTTXETP00000002638 (Silurana tropicalis) 336 76.00% ORF Names:NFIA_109330 EMBL EAW25439.1OrganismNeosartorya fischeri (strain ATCC 1020 / DSM 3700 / Mitochondrial import receptor subunit FGSC A1164 / NRRL 181) (Aspergillus TOM40 homolog (Translocase of outer Xenopus tropicalis (Western clawed frog) fischerianus) ARP35374_P050 TOM40_XENTR membrane 40 kDa subunit homolog) (Silurana tropicalis) 336 76.00% ORF Names:NFIA_109330 EMBL EAW25439.1OrganismNeosartorya fischeri (strain ATCC 1020 / DSM 3700 / Mitochondrial import receptor subunit FGSC A1164 / NRRL 181) (Aspergillus TOM40 homolog (Translocase of outer fischerianus) ARP35374_P050 TOM40_XENLA membrane 40 kDa subunit homolog) Xenopus laevis (African clawed frog) 336 76.00%

Polyadenylate‐binding protein 1‐B (PABP‐1‐B) (Poly(A)‐binding protein 1‐B) (xPABP1‐B) PABPC1 ARP40403_P050 PABPB_XENLA (Cytoplasmic poly(A)‐binding protein 1‐B) Xenopus laevis (African clawed frog) 633 86.00% Xenopus tropicalis (Western clawed frog) PABPC1 ARP40403_P050 Q6DF12_XENTR Polyadenylate‐binding protein 1 (Silurana tropicalis) 634 86.00%

Polyadenylate‐binding protein 1‐A (PABP‐1‐A) (Poly(A)‐binding protein 1‐A) (xPABP1‐A) PABPC1 ARP40403_P050 PABPA_XENLA (Cytoplasmic poly(A)‐binding protein 1‐A) Xenopus laevis (African clawed frog) 633 86.00% TRIM2 ARP34698_T100 Q6GM89_XENLA MGC82029 protein Xenopus laevis (African clawed frog) 744 78.00% TRIM2 ARP34698_T100 Q6GQA4_XENLA MGC80218 protein Xenopus laevis (African clawed frog) 748 83.00% Xenopus tropicalis (Western clawed frog) TRIM2 ARP34698_T100 Q6DJS4_XENTR Tripartite motif‐containing 2 (Silurana tropicalis) 760 83.00% ORF Names:v1g169263OrganismNematostel la vectensis (Starlet sea anemone) ARP42968_P050 Q7ZYS9_XENLA Tm4sf9 protein Xenopus laevis (African clawed frog) 268 100.00%

ORF Names:v1g169263OrganismNematostel la vectensis (Starlet sea anemone) ARP42968_P050 Q501Q6_XENLA MGC99260 protein Xenopus laevis (African clawed frog) 268 100.00%

ORF Names:v1g169263OrganismNematostel Xenopus tropicalis (Western clawed frog) la vectensis (Starlet sea anemone) ARP42968_P050 Q0VFQ2_XENTR Tetraspanin 5 (Silurana tropicalis) 268 100.00%

ORF Names:v1g169263OrganismNematostel la vectensis (Starlet sea anemone) ARP42968_P050 Q6NRM4_XENLA MGC83687 protein Xenopus laevis (African clawed frog) 270 92.00%

ORF Names:v1g169263OrganismNematostel Xenopus tropicalis (Western clawed frog) la vectensis (Starlet sea anemone) ARP42968_P050 Q6DIL0_XENTR F‐box protein 23 (Silurana tropicalis) 270 92.00% ARP45629_P050 Q9W745_XENLA COUP transcription factor 1 Xenopus laevis (African clawed frog) 411 78.00% Xenopus tropicalis (Western clawed frog) ARP45629_P050 A4QNF4_XENTR Nr2f1 protein (Silurana tropicalis) 410 78.00% Xenopus tropicalis (Western clawed frog) dpysl2 ARP41934_P050 Q0V9W2_XENTR Collapsin response mediator protein 1 (Silurana tropicalis) 680 85.00% dpysl2 ARP41934_P050 Q566H1_XENLA MGC115310 protein Xenopus laevis (African clawed frog) 612 85.00% dpysl2 ARP41934_P050 Q6PB02_XENLA MGC68668 protein Xenopus laevis (African clawed frog) 573 83.00% Xenopus tropicalis (Western clawed frog) dpysl2 ARP41934_P050 B2GUD4_XENTR LOC100158561 protein (Silurana tropicalis) 656 83.00%

DNA replication licensing factor mcm2 Xenopus tropicalis (Western clawed frog) ARP36646_P050 MCM2_XENTR (Minichromosome maintenance protein 2) (Silurana tropicalis) 884 100.00% DNA replication licensing factor mcm2 (BM28‐ homolog) (Minichromosome maintenance ARP36646_P050 MCM2_XENLA protein 2) (xMCM2) (p112) Xenopus laevis (African clawed frog) 886 100.00% Forkhead box protein D1 (FoxD1) (Brain factor Xenopus tropicalis (Western clawed frog) Foxd1 ARP32973_P050 FOXD1_XENTR 2) (BF‐2) (Silurana tropicalis) 329 91.00% Forkhead box protein D1 (FoxD1) (Brain factor Foxd1 ARP32973_P050 FOXD1_XENLA 2) (BF‐2) (xBF‐2) (Xbf2) Xenopus laevis (African clawed frog) 345 91.00% slc25a36 ARP43984_P050 Q32NL1_XENLA MGC131068 protein Xenopus laevis (African clawed frog) 71 87.00% slc25a36 ARP43984_P050 A5PKR9_XENLA LOC100101316 protein Xenopus laevis (African clawed frog) 309 87.00% Xenopus tropicalis (Western clawed frog) ARP44429_T100 B0JZ44_XENTR Zfyve27 protein (Silurana tropicalis) 409 92.00% Xenopus tropicalis (Western clawed frog) SYNGR1 ARP46485_P050 Q6DIE7_XENTR Synaptogyrin 2 (Silurana tropicalis) 219 85.00% SYNGR1 ARP46485_P050 Q8UW67_XENLA P7D11 (P7D11 protein) Xenopus laevis (African clawed frog) 231 84.00% SYNGR1 ARP46485_P050 Q5PPX8_XENLA LOC496048 protein Xenopus laevis (African clawed frog) 231 84.00% Xenopus tropicalis (Western clawed frog) SYNGR1 ARP46485_P050 Q28CJ1_XENTR Synaptogyrin 1 (Silurana tropicalis) 231 84.00% Xenopus tropicalis (Western clawed frog) SYNGR1 ARP46485_P050 A8E5R9_XENTR Putative uncharacterized protein (Silurana tropicalis) 193 84.00% SYNGR1 ARP46485_P050 Q6AZR4_XENLA Syngr2‐prov protein Xenopus laevis (African clawed frog) 217 78.00%

FAD synthase (EC 2.7.7.2) (FAD pyrophosphorylase) (FMN adenylyltransferase) (Flavin adenine ORF Names:MED193_16072 EMBL dinucleotide synthase) [Includes: EAQ46728.1OrganismRoseobacter sp. Molybdenum cofactor biosynthesis protein‐ MED193 ARP49205_P050 FLAD1_XENLA like region; FAD synthase region] Xenopus laevis (African clawed frog) 496 100.00% acnA ARP56302_P050 Q9PUG0_XENLA Aconitase Xenopus laevis (African clawed frog) 856 100.00% acnA ARP56302_P050 Q6NTP7_XENLA LOC398139 protein Xenopus laevis (African clawed frog) 782 100.00% acnA ARP56302_P050 Q6DKB9_XENLA MGC84375 protein Xenopus laevis (African clawed frog) 782 100.00% Xenopus tropicalis (Western clawed frog) acnA ARP56302_P050 Q5I0B1_XENTR Aconitase 2, mitochondrial (Silurana tropicalis) 781 100.00%

SHC‐transforming protein 1 (Src 2 domain‐containing‐transforming protein C1) Shc4 ARP50490_P050 SHC1_XENLA (SH2 domain protein C1) (p60Shc) Xenopus laevis (African clawed frog) 465 100.00% ARP49584_P050 Q2V0J3_XENLA Semaphorin 6D4 Xenopus laevis (African clawed frog) 1085 92.00% Xenopus tropicalis (Western clawed frog) ARP49584_P050 B0JZE6_XENTR Sema6d protein (Silurana tropicalis) 1084 92.00% Xenopus tropicalis (Western clawed frog) YAF2 ARP38972_P050 Q28DL7_XENTR RING1 and YY1 binding protein (Silurana tropicalis) 336 100.00% LOC100127335 protein (Putative YAF2 ARP38972_P050 A9JS84_XENLA uncharacterized protein LOC100127335) Xenopus laevis (African clawed frog) 333 100.00% Xenopus tropicalis (Western clawed frog) YAF2 ARP38972_P050 Q6PBG0_XENTR Putative uncharacterized protein MGC75686 (Silurana tropicalis) 180 92.00% YAF2 ARP38972_P050 Q6GPC1_XENLA LOC443631 protein (Fragment) Xenopus laevis (African clawed frog) 81 92.00% YAF2 ARP38972_P050 Q3KQD2_XENLA Putative uncharacterized protein Xenopus laevis (African clawed frog) 180 92.00% SALL3 ARP32570_P050 Q91929_XENLA Zinc finger protein Xenopus laevis (African clawed frog) 1350 85.00% SALL3 ARP32570_P050 Q5XH70_XENLA Sall3 protein Xenopus laevis (African clawed frog) 1259 85.00% Xenopus tropicalis (Western clawed frog) ARP42167_P050 Q5M8Z5_XENTR Carbonic anhydrase VIII (Silurana tropicalis) 282 92.00% ARP42167_P050 Q8AVG8_XENLA Ca2‐prov protein Xenopus laevis (African clawed frog) 260 83.00% UBE4A ARP43044_P050 Q6NTM3_XENLA LOC414451 protein (Fragment) Xenopus laevis (African clawed frog) 957 100.00% UBE4A ARP43044_P050 Q4FZX1_XENLA LOC414451 protein Xenopus laevis (African clawed frog) 1072 100.00% slit1 ARP58765_P050 Q7ZXI2_XENLA Slit1 protein Xenopus laevis (African clawed frog) 1529 78.00% Xenopus tropicalis (Western clawed frog) slit1 ARP58765_P050 A1A5F4_XENTR Slit1 protein (Silurana tropicalis) 1529 78.00% Nlgn3 ARP49556_P050 Q6AX56_XENLA MGC84475 protein (Neuroligin 3) Xenopus laevis (African clawed frog) 803 100.00% Xenopus tropicalis (Western clawed frog) Nlgn3 ARP49556_P050 D2X2K7_XENTR Neuroligin 4 (Silurana tropicalis) 813 100.00% Xenopus tropicalis (Western clawed frog) Nlgn3 ARP49556_P050 D2X2K6_XENTR Neuroligin 3 (Silurana tropicalis) 803 100.00% Xenopus tropicalis (Western clawed frog) Nlgn3 ARP49556_P050 D2X2K5_XENTR Neuroligin 2 (Fragment) (Silurana tropicalis) 651 100.00% Xenopus tropicalis (Western clawed frog) Nlgn3 ARP49556_P050 D2X2K4_XENTR Neuroligin 1 (Silurana tropicalis) 837 92.00% Enoyl Coenzyme A hydratase, short chain, 1, Xenopus tropicalis (Western clawed frog) Echs1 ARP45699_T100 Q6GLG0_XENTR mitochondrial (Silurana tropicalis) 286 85.00% Echs1 ARP45699_T100 Q2VPL7_XENLA LOC733431 protein (Fragment) Xenopus laevis (African clawed frog) 285 85.00% Xenopus tropicalis (Western clawed frog) P4HB ARP48150_P050 Q6P1T4_XENTR p4hb protein (Fragment) (Silurana tropicalis) 509 85.00% Procollagen‐proline, 2‐oxoglutarate 4‐ dioxygenase (Proline 4‐hydroxylase), beta polypeptide (Protein disulfide isomerase‐ associated 1) (Prolyl 4‐hydroxylase, beta Xenopus tropicalis (Western clawed frog) P4HB ARP48150_P050 Q28EC8_XENTR polypeptide) (Silurana tropicalis) 506 85.00% P4HB ARP48150_P050 Q7ZTJ5_XENLA P4hb protein (Fragment) Xenopus laevis (African clawed frog) 517 78.00% P4HB ARP48150_P050 Q7SY98_XENLA MGC64309 protein Xenopus laevis (African clawed frog) 505 78.00% P4HB ARP48150_P050 Q6DD55_XENLA P4hb protein Xenopus laevis (African clawed frog) 506 78.00% Ordered Locus Names:Sama_0285OrganismShewanell a amazonensis (strain ATCC BAA‐1098 / SB2B) ARP53100_P050 Q6NUA9_XENLA MGC81095 protein Xenopus laevis (African clawed frog) 240 85.00% Ordered Locus Names:Sama_0285OrganismShewanell a amazonensis (strain ATCC BAA‐1098 / Haloacid dehalogenase‐like hydrolase domain Xenopus tropicalis (Western clawed frog) SB2B) ARP53100_P050 Q28I22_XENTR containing 4 (Silurana tropicalis) 240 85.00% ZFX ARP33498_P050 Q6NRV1_XENLA XZFY‐1 protein Xenopus laevis (African clawed frog) 794 92.00%

ZFX ARP33498_P050 ZFY1_XENLA Zinc finger Y‐chromosomal protein 1 (ZFY‐1) Xenopus laevis (African clawed frog) 794 92.00%

Eukaryotic initiation factor 4A‐III (eIF‐4A‐III) (eIF4A‐III) (EC 3.6.4.13) (ATP‐dependent RNA helicase DDX48) (ATP‐dependent RNA helicase eIF4A‐3) (DEAD box protein 48) (Eukaryotic Xenopus tropicalis (Western clawed frog) fal1 ARP36422_T100 IF4A3_XENTR translation initiation factor 4A isoform 3) (Silurana tropicalis) 415 100.00% Eukaryotic initiation factor 4A‐III‐B (XeIF‐4AIII) (eIF‐4A‐III‐B) (eIF4A‐III‐B) (EC 3.6.4.13) (ATP‐ dependent RNA helicase DDX48‐B) (ATP‐ dependent RNA helicase eIF4A‐3‐B) (DEAD box protein 48‐B) (Eukaryotic translation fal1 ARP36422_T100 I4A3B_XENLA initiation factor 4A isoform 3‐B) Xenopus laevis (African clawed frog) 414 100.00%

Eukaryotic initiation factor 4A‐III‐A (eIF‐4A‐III‐ A) (eIF4A‐III‐A) (EC 3.6.4.13) (ATP‐dependent RNA helicase DDX48‐A) (ATP‐dependent RNA helicase eIF4A‐3‐A) (DEAD box protein 48‐A) (Eukaryotic translation initiation factor 4A fal1 ARP36422_T100 I4A3A_XENLA isoform 3 A) Xenopus laevis (African clawed frog) 415 100.00% CIR ARP33737_P050 Q66IU3_XENLA LOC446936 protein (Fragment) Xenopus laevis (African clawed frog) 240 91.00%

ORF Names:GSTENG00015913001 EMBL CAF98264.1OrganismTetraodon nigroviridis (Green puffer) ARP42648_P050 Q5EAZ4_XENLA MGC84987 protein Xenopus laevis (African clawed frog) 373 100.00%

ORF Names:GSTENG00015913001 EMBL CAF98264.1OrganismTetraodon Xenopus tropicalis (Western clawed frog) nigroviridis (Green puffer) ARP42648_P050 B1H376_XENTR LOC100145566 protein (Silurana tropicalis) 367 100.00% Stau1 ARP40536_P050 Q6JPI2_XENLA Staufen Xenopus laevis (African clawed frog) 712 100.00% Stau1 ARP40536_P050 Q6GM35_XENLA Stau1 protein Xenopus laevis (African clawed frog) 708 100.00% Stau1 ARP40536_P050 Q5MNU4_XENLA Staufen 1 Xenopus laevis (African clawed frog) 718 100.00% Xenopus tropicalis (Western clawed frog) Stau1 ARP40536_P050 Q28HT0_XENTR Novel protein similar to staufen (Silurana tropicalis) 696 100.00% Xenopus tropicalis (Western clawed frog) Stau1 ARP40536_P050 Q0IHZ5_XENTR Stau1 protein (Silurana tropicalis) 686 100.00% Stau1 ARP40536_P050 Q6PAB6_XENLA LOC398937 protein (Fragment) Xenopus laevis (African clawed frog) 426 92.00% Stau1 ARP40536_P050 Q4KLR2_XENLA LOC398937 protein (Fragment) Xenopus laevis (African clawed frog) 380 92.00%

ORF Names:v1g110650OrganismNematostel Xenopus tropicalis (Western clawed frog) la vectensis (Starlet sea anemone) ARP41594_P050 A4IHG7_XENTR LOC549100 protein (Silurana tropicalis) 316 100.00%

ORF Names:v1g110650OrganismNematostel Xenopus tropicalis (Western clawed frog) la vectensis (Starlet sea anemone) ARP41594_P050 CK054_XENTR Ester hydrolase C11orf54 homolog (EC 3.1.‐.‐) (Silurana tropicalis) 313 100.00% ORF Names:v1g110650OrganismNematostel la vectensis (Starlet sea anemone) ARP41594_P050 CK054_XENLA Ester hydrolase C11orf54 homolog (EC 3.1.‐.‐) Xenopus laevis (African clawed frog) 316 100.00% Nuclear receptor subfamily 2 group C member 1 (Developmental orphan receptor 2) (DOR2) (Orphan nuclear receptor TR2) (Testicular Xenopus tropicalis (Western clawed frog) NR2C1 ARP38286_P050 NR2C1_XENTR receptor 2) (Silurana tropicalis) 636 76.00%

Nuclear receptor subfamily 2 group C member 1‐B (Developmental orphan receptor 2‐B) (DOR2‐B) (xDOR2‐B) (Orphan nuclear receptor NR2C1 ARP38286_P050 N2C1B_XENLA TR2‐B) ( 2‐B) Xenopus laevis (African clawed frog) 637 76.00%

Nuclear receptor subfamily 2 group C member 1‐A (Developmental orphan receptor 2‐A) (DOR2‐A) (xDOR2‐A) (Orphan nuclear receptor NR2C1 ARP38286_P050 N2C1A_XENLA TR2‐A) (‐A) Xenopus laevis (African clawed frog) 637 76.00% ACO2 ARP56301_P050 Q9PUG0_XENLA Aconitase Xenopus laevis (African clawed frog) 856 92.00% ACO2 ARP56301_P050 Q6NTP7_XENLA LOC398139 protein Xenopus laevis (African clawed frog) 782 92.00% Xenopus tropicalis (Western clawed frog) ACO2 ARP56301_P050 Q5I0B1_XENTR Aconitase 2, mitochondrial (Silurana tropicalis) 781 92.00% ACO2 ARP56301_P050 Q6DKB9_XENLA MGC84375 protein Xenopus laevis (African clawed frog) 782 78.00%

Mediator of RNA polymerase II transcription Xenopus tropicalis (Western clawed frog) ARP34219_P050 B3DLE4_XENTR subunit 6 (Mediator complex subunit 6) (Silurana tropicalis) 246 84.00% Xenopus tropicalis (Western clawed frog) acsbg2 ARP53793_P050 B2GU97_XENTR LOC100158533 protein (Silurana tropicalis) 741 92.00%

Long‐chain‐fatty‐acid‐‐CoA ligase ACSBG2 (EC 6.2.1.3) (Acyl‐CoA synthetase bubblegum acsbg2 ARP53793_P050 ACBG2_XENLA family member 2) Xenopus laevis (African clawed frog) 739 92.00% ptbp2 ARP40422_P050 Q7ZXB4_XENLA Ptbp1 protein Xenopus laevis (African clawed frog) 547 100.00% Xenopus tropicalis (Western clawed frog) ptbp2 ARP40422_P050 Q5XGH0_XENTR Polypyrimidine tract binding protein 1 (Silurana tropicalis) 554 100.00% ptbp2 ARP40422_P050 Q4QR55_XENLA VgRBP60 protein Xenopus laevis (African clawed frog) 472 100.00% Xenopus tropicalis (Western clawed frog) ptbp2 ARP40422_P050 Q0P4U3_XENTR Polypyrimidine tract binding protein 2 (Silurana tropicalis) 531 92.00% Xenopus tropicalis (Western clawed frog) ptbp2 ARP40422_P050 B1H3K0_XENTR LOC100145652 protein (Silurana tropicalis) 519 100.00% HnRNP I‐related RNA transport protein ptbp2 ARP40422_P050 Q9PTS5_XENLA VgRBP60 Xenopus laevis (African clawed frog) 552 92.00% MTHFD2L ARP46163_P050 Q6DDQ6_XENLA Mthfd2‐prov protein Xenopus laevis (African clawed frog) 335 92.00% Xenopus tropicalis (Western clawed frog) MTHFD2L ARP46163_P050 B3DL74_XENTR LOC100170462 protein (Silurana tropicalis) 335 92.00% MTHFD2L ARP46163_P050 Q6IP36_XENLA MGC78982 protein Xenopus laevis (African clawed frog) 335 85.00% MTHFD2L ARP46163_P050 Q2VPP2_XENLA MGC78982 protein Xenopus laevis (African clawed frog) 335 85.00% ORF Names:GSPATT00038313001 EMBL CAK70211.1OrganismParamecium tetraurelia ARP48185_T100 Q7ZWR6_XENLA Atp5b protein Xenopus laevis (African clawed frog) 525 92.00% ORF Names:GSPATT00038313001 EMBL CAK70211.1OrganismParamecium ATP synthase, H+ transporting, mitochondrial Xenopus tropicalis (Western clawed frog) tetraurelia ARP48185_T100 Q6NWX0_XENTR F1 complex, beta polypeptide (Silurana tropicalis) 525 92.00% FBXO11 ARP43327_P050 Q6DF73_XENLA Fbxo11‐prov protein Xenopus laevis (African clawed frog) 843 100.00% hs3st2 ARP48502_P050 A9JS30_XENLA Putative uncharacterized protein Xenopus laevis (African clawed frog) 347 78.00% hs3st2 ARP48502_P050 A2RV64_XENLA LOC100037135 protein (Fragment) Xenopus laevis (African clawed frog) 414 78.00% Xenopus tropicalis (Western clawed frog) ARP40023_T100 B3DL96_XENTR Tfap2e protein (Silurana tropicalis) 434 76.00% EEF2 ARP58457_P050 Q7ZXP8_XENLA Eef2‐prov protein Xenopus laevis (African clawed frog) 858 100.00% EEF2 ARP58457_P050 Q6PAV9_XENLA MGC68699 protein Xenopus laevis (African clawed frog) 350 100.00% Xenopus tropicalis (Western clawed frog) EEF2 ARP58457_P050 Q6P3N8_XENTR Eukaryotic translation elongation factor 2 (Silurana tropicalis) 858 100.00% Xenopus tropicalis (Western clawed frog) EEF2 ARP58457_P050 Q5FVX0_XENTR MGC108369 protein (Silurana tropicalis) 859 100.00% EEF2 ARP58457_P050 Q52MA1_XENLA Putative uncharacterized protein Xenopus laevis (African clawed frog) 858 100.00% EEF2 ARP58457_P050 Q6AZM9_XENLA Eft‐2‐prov protein Xenopus laevis (African clawed frog) 850 85.00% Mitochondrial import receptor subunit TOM40 homolog (Translocase of outer Tomm40l ARP35373_P050 TOM40_XENLA membrane 40 kDa subunit homolog) Xenopus laevis (African clawed frog) 336 76.00% Xenopus tropicalis (Western clawed frog) Tmem69 ARP47258_P050 TMM69_XENTR Transmembrane protein 69 (Silurana tropicalis) 253 84.00% Xenopus tropicalis (Western clawed frog) Cacnb4 ARP34958_P050 B5DDZ7_XENTR Putative uncharacterized protein (Silurana tropicalis) 486 100.00% Voltage‐dependent calcium channel beta Cacnb4 ARP34958_P050 Q91629_XENLA subunit Xenopus laevis (African clawed frog) 484 92.00% Voltage‐dependent calcium channel beta Cacnb4 ARP34958_P050 Q91630_XENLA subunit Xenopus laevis (African clawed frog) 484 85.00% pdi ARP48151_P050 Q7ZTJ5_XENLA P4hb protein (Fragment) Xenopus laevis (African clawed frog) 517 92.00% pdi ARP48151_P050 Q7SY98_XENLA MGC64309 protein Xenopus laevis (African clawed frog) 505 92.00% Xenopus tropicalis (Western clawed frog) pdi ARP48151_P050 Q6P1T4_XENTR p4hb protein (Fragment) (Silurana tropicalis) 509 92.00% pdi ARP48151_P050 Q6DD55_XENLA P4hb protein Xenopus laevis (African clawed frog) 506 92.00% Procollagen‐proline, 2‐oxoglutarate 4‐ dioxygenase (Proline 4‐hydroxylase), beta polypeptide (Protein disulfide isomerase‐ associated 1) (Prolyl 4‐hydroxylase, beta Xenopus tropicalis (Western clawed frog) pdi ARP48151_P050 Q28EC8_XENTR polypeptide) (Silurana tropicalis) 506 92.00% CG5276 ARP52640_P050 Q8AVX8_XENLA Apyrase (MGC52693 protein) Xenopus laevis (African clawed frog) 400 92.00% Xenopus tropicalis (Western clawed frog) CG5276 ARP52640_P050 Q6P853_XENTR Calcium activated nucleotidase 1 (Silurana tropicalis) 400 92.00% DNA replication licensing factor mcm7 (CDC47 homolog) (Minichromosome maintenance Xenopus tropicalis (Western clawed frog) MCM7A ARP36667_T100 MCM7_XENTR protein 7) (Silurana tropicalis) 720 85.00% DNA replication licensing factor mcm7‐B (CDC47 homolog B) (CDC47‐2p) (Minichromosome maintenance protein 7‐B) MCM7A ARP36667_T100 MCM7B_XENLA (xMCM7‐B) Xenopus laevis (African clawed frog) 720 85.00% DNA replication licensing factor mcm7‐A (CDC47 homolog A) (CDC47p) (Minichromosome maintenance protein 7‐A) MCM7A ARP36667_T100 MCM7A_XENLA (xMCM7‐A) (p90) Xenopus laevis (African clawed frog) 720 85.00%

ORF Names:zgc:162207 ZFIN ZDB‐GENE‐ 070410‐36OrganismDanio rerio (Zebrafish) (Brachydanio rerio) ARP48451_P050 Q6DJL4_XENLA MGC82059 protein Xenopus laevis (African clawed frog) 110 85.00%

ORF Names:zgc:162207 ZFIN ZDB‐GENE‐ 070410‐36OrganismDanio rerio Xenopus tropicalis (Western clawed frog) (Zebrafish) (Brachydanio rerio) ARP48451_P050 B4F6Y2_XENTR Putative uncharacterized protein (Silurana tropicalis) 109 85.00% Xenopus tropicalis (Western clawed frog) GABRB3 ARP35339_P050 A4IIK0_XENTR Gabrb3 protein (Silurana tropicalis) 475 92.00% Xenopus tropicalis (Western clawed frog) GABRB3 ARP35339_P050 A4IIN3_XENTR LOC100125027 protein (Silurana tropicalis) 474 78.00%

MGC97768 protein (Psf2, Subunit of the GINS Xenopus tropicalis (Western clawed frog) PSF2 ARP46238_P050 Q5EB27_XENTR complex (Sld5p, Psf1p, Psf2p, Psf3p)) (Silurana tropicalis) 185 100.00% DNA replication complex GINS protein PSF2 PSF2 ARP46238_P050 PSF2_XENLA (GINS complex subunit 2) Xenopus laevis (African clawed frog) 185 92.00% CCHC‐type zinc finger, nucleic acid binding Xenopus tropicalis (Western clawed frog) ARP34815_P050 Q6GL15_XENTR protein (Silurana tropicalis) 138 76.00%

Cnbp protein (Zinc finger protein 9 (A cellular Xenopus tropicalis (Western clawed frog) ARP34815_P050 Q28IH9_XENTR retroviral nucleic acid binding protein)) (Silurana tropicalis) 177 76.00% ARP34815_P050 P70000_XENLA Cellular nucleic acid binding protein Xenopus laevis (African clawed frog) 178 76.00% ARP34815_P050 B7ZQB4_XENLA CNBP protein Xenopus laevis (African clawed frog) 178 76.00% ORF Names:TRIADDRAFT_27646 EMBL EDV23007.1OrganismTrichoplax Xenopus tropicalis (Western clawed frog) adhaerens (Trichoplax reptans) ARP48825_P050 Q0VFP8_XENTR Ogfod1 protein (Silurana tropicalis) 470 92.00%

ORF Names:TRIADDRAFT_27646 EMBL EDV23007.1OrganismTrichoplax 2‐oxoglutarate and iron‐dependent adhaerens (Trichoplax reptans) ARP48825_P050 OGFD1_XENLA domain‐containing protein 1 (EC 1.14.11.‐) Xenopus laevis (African clawed frog) 511 92.00% Xenopus tropicalis (Western clawed frog) LOC100036667 ARP42990_P050 B3DLM9_XENTR LOC100036667 protein (Silurana tropicalis) 1049 91.00% Xenopus tropicalis (Western clawed frog) LOC100036667 ARP42990_P050 A0JPD5_XENTR LOC100036667 protein (Fragment) (Silurana tropicalis) 967 91.00% LOC100036667 ARP42990_P050 Q6DDX6_XENLA MGC81587 protein Xenopus laevis (African clawed frog) 677 83.00% LOC100036667 ARP42990_P050 Q2TAE1_XENLA MGC81587 protein Xenopus laevis (African clawed frog) 897 83.00% LOC100036667 ARP42990_P050 Q5XG62_XENLA LOC495281 protein (Fragment) Xenopus laevis (African clawed frog) 1031 90.00% PURA ARP38688_P050 Q6AZK2_XENLA Pura‐prov protein Xenopus laevis (African clawed frog) 282 87.00% LOC100135162 protein (Putative Xenopus tropicalis (Western clawed frog) PURA ARP38688_P050 A9UL75_XENTR uncharacterized protein LOC100135162) (Silurana tropicalis) 282 87.00% Xenopus tropicalis (Western clawed frog) Blmh ARP56106_P050 Q6GL32_XENTR Bleomycin hydrolase (Silurana tropicalis) 453 92.00% Blmh ARP56106_P050 Q5BL86_XENLA MGC85088 protein Xenopus laevis (African clawed frog) 453 76.00% ORF Names:PHYPADRAFT_130338 EMBL EDQ69144.1OrganismPhyscomitrella Xenopus tropicalis (Western clawed frog) patens subsp. patens (Moss) ARP46292_P050 B5DET5_XENTR Nit2 protein (Fragment) (Silurana tropicalis) 275 92.00% ORF Names:PHYPADRAFT_130338 EMBL EDQ69144.1OrganismPhyscomitrella Omega‐ NIT2 (EC 3.5.1.3) ( Xenopus tropicalis (Western clawed frog) patens subsp. patens (Moss) ARP46292_P050 NIT2_XENTR homolog 2) (Silurana tropicalis) 276 92.00% ORF Names:PHYPADRAFT_130338 EMBL EDQ69144.1OrganismPhyscomitrella Omega‐amidase NIT2‐A (EC 3.5.1.3) (Nitrilase patens subsp. patens (Moss) ARP46292_P050 NIT2A_XENLA homolog 2) Xenopus laevis (African clawed frog) 276 92.00% ORF Names:PHYPADRAFT_130338 EMBL EDQ69144.1OrganismPhyscomitrella Omega‐amidase NIT2‐B (EC 3.5.1.3) (Nitrilase patens subsp. patens (Moss) ARP46292_P050 NIT2B_XENLA homolog 2) Xenopus laevis (African clawed frog) 276 85.00% ORF Names:OsI_03282 EMBL EAY75384.1OrganismOryza sativa Xenopus tropicalis (Western clawed frog) subsp. indica (Rice) ARP53064_P050 CA055_XENTR UPF0667 protein C1orf55 homolog (Silurana tropicalis) 468 100.00% ORF Names:OsI_03282 EMBL EAY75384.1OrganismOryza sativa subsp. indica (Rice) ARP53064_P050 CA055_XENLA UPF0667 protein C1orf55 homolog Xenopus laevis (African clawed frog) 454 100.00% ORF Names:OsI_03282 EMBL EAY75384.1OrganismOryza sativa subsp. indica (Rice) ARP53064_P050 Q5U561_XENLA LOC495359 protein Xenopus laevis (African clawed frog) 501 84.00% FZD10 ARP41262_P050 Q6INZ3_XENLA Fzd10b protein Xenopus laevis (African clawed frog) 580 92.00% Frizzled homolog 10 (Frizzled homolog 10 Xenopus tropicalis (Western clawed frog) FZD10 ARP41262_P050 Q6GL20_XENTR (Drosophila)) (Silurana tropicalis) 585 92.00% FZD10 ARP41262_P050 B7ZQP6_XENLA Frizzled 10A Xenopus laevis (African clawed frog) 586 92.00% Frizzled‐10‐B (Fz‐10B) (Xfz10‐B) (Frizzled‐9) (Fz‐ FZD10 ARP41262_P050 FZ10B_XENLA 9) (Xfz9) Xenopus laevis (African clawed frog) 580 92.00% FZD10 ARP41262_P050 FZ10A_XENLA Frizzled‐10‐A (Fz‐10A) (Xfz10‐A) Xenopus laevis (African clawed frog) 586 92.00% SLC8A3 ARP44074_P050 Q6DFH6_XENLA Slc8a2‐prov protein Xenopus laevis (African clawed frog) 589 92.00% Xenopus tropicalis (Western clawed frog) SLC8A3 ARP44074_P050 A2RR49_XENTR Solute carrier family 8 member 3 (Fragment) (Silurana tropicalis) 377 92.00%

SLC8A3 ARP44074_P050 A2I5Q0_9PIPI Solute carrier family 8 member 3 (Fragment) Xenopus wittei (Witte's clawed frog) 374 92.00% LOC100135404 protein (Putative Xenopus tropicalis (Western clawed frog) pdap1 ARP58790_P050 A9UMU0_XENTR uncharacterized protein LOC100135404) (Silurana tropicalis) 179 92.00% pdap1 ARP58790_P050 Q6GN46_XENLA MGC83035 protein Xenopus laevis (African clawed frog) 177 92.00% pdap1 ARP58790_P050 Q68EZ8_XENLA MGC83384 protein Xenopus laevis (African clawed frog) 172 92.00% Xenopus tropicalis (Western clawed frog) ARP32692_P050 B4F6J9_XENTR Putative uncharacterized protein (Silurana tropicalis) 905 92.00% Xenopus tropicalis (Western clawed frog) ARP32692_P050 B0JZ57_XENTR Putative uncharacterized protein (Fragment) (Silurana tropicalis) 655 92.00%

Methionyl‐tRNA synthetase, cytoplasmic (EC ARP32692_P050 SYMC_XENLA 6.1.1.10) (Methionine‐‐tRNA ligase) (MetRS) Xenopus laevis (African clawed frog) 905 92.00% ARP32692_P050 Q6AZT3_XENLA Mars‐prov protein Xenopus laevis (African clawed frog) 905 85.00% Guanine nucleotide binding protein (G protein), alpha activating activity polypeptide Xenopus tropicalis (Western clawed frog) ARP55424_P050 Q28EM9_XENTR O (Silurana tropicalis) 354 92.00% Guanine nucleotide‐binding protein G(O) ARP55424_P050 O93564_XENLA alpha subunit 1 Xenopus laevis (African clawed frog) 354 92.00% Alpha 01 subunit of heterotrimeric GTP‐ ARP55424_P050 O13011_XENLA binding protein (Gnao1‐A protein) Xenopus laevis (African clawed frog) 354 92.00% ARP55424_P050 B7ZR93_XENLA G protein alpha subunit Xenopus laevis (African clawed frog) 354 92.00% ARP55424_P050 B7ZR87_XENLA G protein alpha subunit Xenopus laevis (African clawed frog) 354 92.00% Guanine nucleotide‐binding protein G(o) ARP55424_P050 GNAO_XENLA subunit alpha Xenopus laevis (African clawed frog) 354 92.00% ARP54614_P050 Q6DKA2_XENLA MGC84783 protein Xenopus laevis (African clawed frog) 1270 85.00% ORF Names:Bm1_01435 EMBL EDP39395.1OrganismBrugia malayi Cdc2‐prov protein (Cell division cycle 2, G1 to Xenopus tropicalis (Western clawed frog) (Filarial nematode worm) AVARP01006_P050 Q6P7L3_XENTR S and G2 to M) (Silurana tropicalis) 302 90.00% ORF Names:Bm1_01435 EMBL EDP39395.1OrganismBrugia malayi Xenopus tropicalis (Western clawed frog) (Filarial nematode worm) AVARP01006_P050 Q28FA6_XENTR Cell division cycle 2, G1 to S and G2 to M (Silurana tropicalis) 302 90.00% ORF Names:Bm1_01435 EMBL EDP39395.1OrganismBrugia malayi (Filarial nematode worm) AVARP01006_P050 B2L5U5_9PIPI Cell division control protein 2‐like (Fragment) Xenopus muelleri (Muller's clawed frog) 184 90.00% ORF Names:Bm1_01435 EMBL EDP39395.1OrganismBrugia malayi Cell division control protein 2‐like beta Xenopus (Silurana) epitropicalis (Cameroon (Filarial nematode worm) AVARP01006_P050 B2L5S3_9PIPI (Fragment) clawed frog) 184 90.00% ORF Names:Bm1_01435 EMBL EDP39395.1OrganismBrugia malayi Cell division control protein 2‐like alpha (Filarial nematode worm) AVARP01006_P050 B2L5S2_9PIPI (Fragment) Xenopus (Silurana) sp. new tetraploid 1 184 90.00% ORF Names:Bm1_01435 EMBL EDP39395.1OrganismBrugia malayi Cell division control protein 2‐like alpha Xenopus (Silurana) epitropicalis (Cameroon (Filarial nematode worm) AVARP01006_P050 B2L5S1_9PIPI (Fragment) clawed frog) 184 90.00% ORF Names:Bm1_01435 EMBL EDP39395.1OrganismBrugia malayi Cell division control protein 2‐like protein 1 (Filarial nematode worm) AVARP01006_P050 B2L431_XENBO (Fragment) Xenopus borealis (Kenyan clawed frog) 184 90.00%

Cyclin‐dependent kinase 1‐B (CDK1‐B) (EC 2.7.11.22) (EC 2.7.11.23) (Cell division control ORF Names:Bm1_01435 EMBL protein 2 homolog 2) (Cell division control EDP39395.1OrganismBrugia malayi protein 2‐B) (Cell division protein kinase 1) (Filarial nematode worm) AVARP01006_P050 CDK1B_XENLA (p34 protein kinase 2) Xenopus laevis (African clawed frog) 302 90.00%

Cyclin‐dependent kinase 1‐A (CDK1‐A) (EC 2.7.11.22) (EC 2.7.11.23) (Cell division control ORF Names:Bm1_01435 EMBL protein 2 homolog 1) (Cell division control EDP39395.1OrganismBrugia malayi protein 2‐A) (Cell division protein kinase 1‐A) (Filarial nematode worm) AVARP01006_P050 CDK1A_XENLA (p34 protein kinase 1) Xenopus laevis (African clawed frog) 302 90.00% ARP55355_P050 Q801Q3_XENLA Ssbp3‐prov protein Xenopus laevis (African clawed frog) 391 100.00% Xenopus tropicalis (Western clawed frog) ARP55355_P050 Q6P4M2_XENTR Single stranded DNA binding protein 3 (Silurana tropicalis) 392 100.00% Xenopus tropicalis (Western clawed frog) ARP55355_P050 B4F6Z1_XENTR Ssbp3 protein (Silurana tropicalis) 391 100.00% Xenopus tropicalis (Western clawed frog) ARP55355_P050 A0JLY6_XENTR Ssbp3 protein (Silurana tropicalis) 396 100.00% ARP55355_P050 Q7ZX94_XENLA MGC53880 protein Xenopus laevis (African clawed frog) 387 85.00% ARP55355_P050 Q7ZYQ7_XENLA Ssbp2‐prov protein Xenopus laevis (African clawed frog) 359 91.00% ARP55355_P050 Q6NRV5_XENLA Ssbp2‐prov protein Xenopus laevis (African clawed frog) 387 91.00% Xenopus tropicalis (Western clawed frog) ARP55355_P050 B4F6X9_XENTR Putative uncharacterized protein (Silurana tropicalis) 387 91.00% ORF Names:ACLA_015240 EMBL EAW13086.1OrganismAspergillus clavatus ARP54638_P050 Q6GM38_XENLA MGC84000 protein Xenopus laevis (African clawed frog) 340 92.00% ORF Names:ACLA_015240 EMBL EAW13086.1OrganismAspergillus Guanine nucleotide binding protein (G Xenopus tropicalis (Western clawed frog) clavatus ARP54638_P050 Q6DF33_XENTR protein), beta polypeptide 2 (Silurana tropicalis) 340 92.00% ORF Names:ACLA_015240 EMBL EAW13086.1OrganismAspergillus clavatus ARP54638_P050 Q5XH13_XENLA XGbeta1 protein Xenopus laevis (African clawed frog) 340 92.00% ORF Names:ACLA_015240 EMBL EAW13086.1OrganismAspergillus clavatus ARP54638_P050 Q5U587_XENLA LOC495335 protein Xenopus laevis (African clawed frog) 340 92.00% ORF Names:ACLA_015240 EMBL EAW13086.1OrganismAspergillus Guanine nucleotide binding protein (G Xenopus tropicalis (Western clawed frog) clavatus ARP54638_P050 Q28G20_XENTR protein), beta polypeptide 4 (Silurana tropicalis) 340 92.00% ORF Names:ACLA_015240 EMBL EAW13086.1OrganismAspergillus Xenopus tropicalis (Western clawed frog) clavatus ARP54638_P050 B3DLQ7_XENTR LOC100170528 protein (Silurana tropicalis) 340 92.00% ORF Names:ACLA_015240 EMBL EAW13086.1OrganismAspergillus Xenopus tropicalis (Western clawed frog) clavatus ARP54638_P050 A4IH33_XENTR LOC549706 protein (Silurana tropicalis) 327 92.00% ORF Names:ACLA_015240 EMBL Guanine nucleotide‐binding protein EAW13086.1OrganismAspergillus G(I)/G(S)/G(T) subunit beta‐1 (Transducin beta clavatus ARP54638_P050 GBB1_XENLA chain 1) (XGbeta1) Xenopus laevis (African clawed frog) 340 92.00% ORF Names:ACLA_015240 EMBL EAW13086.1OrganismAspergillus clavatus ARP54638_P050 Q7T0Y9_XENLA Gnb1 protein Xenopus laevis (African clawed frog) 340 92.00% ORF Names:ACLA_015240 EMBL EAW13086.1OrganismAspergillus clavatus ARP54638_P050 Q7SZU2_XENLA Gnb3 protein Xenopus laevis (African clawed frog) 340 92.00% ORF Names:ACLA_015240 EMBL EAW13086.1OrganismAspergillus Xenopus tropicalis (Western clawed frog) clavatus ARP54638_P050 Q5XGD8_XENTR Guanine nucleotide binding protein, beta 3 (Silurana tropicalis) 340 92.00% ARP55434_P050 Q6INB9_XENLA MGC83546 protein Xenopus laevis (African clawed frog) 666 100.00% Xenopus tropicalis (Western clawed frog) ARP55434_P050 A4QNC4_XENTR LOC100125136 protein (Silurana tropicalis) 664 100.00% Xenopus tropicalis (Western clawed frog) ARP55434_P050 Q6P4W9_XENTR Bridging integrator 1 (Silurana tropicalis) 508 92.00% ARP55434_P050 Q6GNI1_XENLA MGC82791 protein Xenopus laevis (African clawed frog) 477 92.00% Xenopus tropicalis (Western clawed frog) ARP55434_P050 Q28BQ9_XENTR Bridging integrator 1 (Silurana tropicalis) 558 92.00% ARP55434_P050 Q7ZWP5_XENLA Bin1‐prov protein Xenopus laevis (African clawed frog) 478 100.00% ORF Names:GSPATT00011633001 EMBL ER lumen protein retaining receptor 3 (KDEL CAK76032.1OrganismParamecium endoplasmic reticulum protein retention Xenopus tropicalis (Western clawed frog) tetraurelia ARP46794_P050 ERD23_XENTR receptor 3) (KDEL receptor 3) (Silurana tropicalis) 214 85.00% ORF Names:GSPATT00011633001 EMBL ER lumen protein retaining receptor 3 (KDEL CAK76032.1OrganismParamecium endoplasmic reticulum protein retention tetraurelia ARP46794_P050 ERD23_XENLA receptor 3) (KDEL receptor 3) Xenopus laevis (African clawed frog) 214 78.00% Hmgb3 ARP38109_P050 Q91596_XENLA High mobility group protein‐1 Xenopus laevis (African clawed frog) 210 100.00% Hmgb3 ARP38109_P050 Q7SZ42_XENLA Hmgb1‐prov protein Xenopus laevis (African clawed frog) 211 100.00% Xenopus tropicalis (Western clawed frog) Hmgb3 ARP38109_P050 Q6P4N5_XENTR High‐mobility group box 1 (Silurana tropicalis) 211 100.00% Hmgb3 ARP38109_P050 Q6GNQ5_XENLA HMG‐1 protein Xenopus laevis (African clawed frog) 210 100.00% Hmgb3 ARP38109_P050 Q91764_XENLA HMG‐X protein Xenopus laevis (African clawed frog) 212 92.00% Hmgb3 ARP38109_P050 Q8AVU3_XENLA MGC52825 protein Xenopus laevis (African clawed frog) 212 92.00% Hmgb3 ARP38109_P050 Q7ZXK5_XENLA MGC52578 protein Xenopus laevis (African clawed frog) 212 92.00% Xenopus tropicalis (Western clawed frog) Hmgb3 ARP38109_P050 Q6P7M9_XENTR High‐mobility group box 2 (Silurana tropicalis) 212 92.00% Hmgb3 ARP38109_P050 Q32NS7_XENLA MGC52825 protein Xenopus laevis (African clawed frog) 211 92.00% Hmgb3 ARP38109_P050 Q7ZY24_XENLA Hmgb3‐prov protein Xenopus laevis (African clawed frog) 202 91.00% High‐mobility group box 3 (MGC88931 Xenopus tropicalis (Western clawed frog) Hmgb3 ARP38109_P050 Q6DJ93_XENTR protein) (Silurana tropicalis) 202 91.00% Hmgb3 ARP38109_P050 B2L4B2_XENBO High mobility group box 3 (Fragment) Xenopus borealis (Kenyan clawed frog) 152 91.00% hnrnpk ARP40387_T100 Q9PSI1_XENLA Pre‐mRNA binding K protein, hnRNP K Xenopus laevis (African clawed frog) 396 100.00% hnrnpk ARP40387_T100 Q7ZXK8_XENLA Hnrpk protein Xenopus laevis (African clawed frog) 399 100.00% Xenopus tropicalis (Western clawed frog) hnrnpk ARP40387_T100 Q6P363_XENTR Heterogeneous nuclear ribonucleoprotein K (Silurana tropicalis) 399 100.00% Xenopus tropicalis (Western clawed frog) hnrnpk ARP40387_T100 Q28HJ9_XENTR Heterogeneous nuclear ribonucleoprotein K (Silurana tropicalis) 376 100.00%

MGC89748 protein (Small nuclear Xenopus tropicalis (Western clawed frog) ARP40533_P050 Q6DDC4_XENTR ribonucleoprotein D2 polypeptide 16.5kDa) (Silurana tropicalis) 118 100.00% ARP40533_P050 Q5HZQ7_XENLA Putative uncharacterized protein Xenopus laevis (African clawed frog) 118 100.00% prkca ARP56425_P050 Q7LZQ9_XENLA Protein kinase C I (EC 2.7.1.‐) Xenopus laevis (African clawed frog) 676 84.00% prkca ARP56425_P050 Q6AZF7_XENLA Prkca‐prov protein Xenopus laevis (African clawed frog) 677 84.00% Xenopus tropicalis (Western clawed frog) prkca ARP56425_P050 A0JM65_XENTR Putative uncharacterized protein MGC146825 (Silurana tropicalis) 678 84.00% Protein kinase C beta type (PKC‐B) (PKC‐beta) Xenopus tropicalis (Western clawed frog) prkca ARP56425_P050 KPCB_XENTR (EC 2.7.11.13) (Silurana tropicalis) 670 76.00% Protein kinase C beta type (PKC‐B) (PKC‐beta) prkca ARP56425_P050 KPCB_XENLA (EC 2.7.11.13) Xenopus laevis (African clawed frog) 671 76.00% ARP44366_T100 Q7SZ26_XENLA Ppib‐prov protein Xenopus laevis (African clawed frog) 216 100.00% ARP44366_T100 Q5XGR3_XENLA LOC495270 protein Xenopus laevis (African clawed frog) 216 100.00% Xenopus tropicalis (Western clawed frog) ARP44366_T100 Q28G13_XENTR Peptidylprolyl isomerase B (Cyclophilin B) (Silurana tropicalis) 208 92.00% purC ARP46049_P050 Q8AVT1_XENLA Paics‐prov protein Xenopus laevis (African clawed frog) 425 92.00% purC ARP46049_P050 Q6GLT0_XENLA MGC84289 protein Xenopus laevis (African clawed frog) 425 92.00% Cbx1 ARP34426_P050 Q6GLP2_XENLA MGC84435 protein Xenopus laevis (African clawed frog) 184 91.00% Chromobox homolog 1 (HP1 beta homolog Xenopus tropicalis (Western clawed frog) Cbx1 ARP34426_P050 Q28HD9_XENTR Drosophila ) (Silurana tropicalis) 184 91.00%

Ordered Locus Names:Pden_4616Encoded onPlasmid pPD1222OrganismParacoccus denitrificans (strain Pd 1222) ARP41467_T100 Q5U5B3_XENLA LOC495311 protein Xenopus laevis (African clawed frog) 497 92.00%

Ordered Locus Names:Pden_4616Encoded onPlasmid pPD1222OrganismParacoccus Dihydropyrimidinase‐related protein 3 (DRP‐ Xenopus tropicalis (Western clawed frog) denitrificans (strain Pd 1222) ARP41467_T100 DPYL3_XENTR 3) (Dihydropyrimidinase‐like 3) (Silurana tropicalis) 571 78.00%

Ordered Locus Names:Pden_4616Encoded onPlasmid Dihydropyrimidinase‐related protein 3‐B (DRP‐ pPD1222OrganismParacoccus 3‐B) (Collapsin response mediator protein 4) denitrificans (strain Pd 1222) ARP41467_T100 DPY3B_XENLA (CRMP‐4) (xCRMP4) Xenopus laevis (African clawed frog) 571 78.00%

Ordered Locus Names:Pden_4616Encoded onPlasmid pPD1222OrganismParacoccus Dihydropyrimidinase‐related protein 3‐A (DRP‐ denitrificans (strain Pd 1222) ARP41467_T100 DPY3A_XENLA 3‐A) (Neural‐specific protein 1) Xenopus laevis (African clawed frog) 571 78.00% SLC25A11 ARP43849_P050 Q0IH35_XENLA MGC154791 protein Xenopus laevis (African clawed frog) 305 92.00% SLC25A11 ARP43849_P050 Q6INH3_XENLA MGC82600 protein Xenopus laevis (African clawed frog) 305 78.00% Xenopus tropicalis (Western clawed frog) SLC25A11 ARP43849_P050 Q566L1_XENTR MGC97830 protein (Silurana tropicalis) 305 78.00% ORF Names:PANDA_004320 EMBL Poly(A) RNA polymerase GLD2‐A (EC 2.7.7.19) EFB25875.1OrganismAiluropoda (PAP‐associated domain‐containing protein 4‐ melanoleuca (Giant panda) ARP49115_P050 GLD2A_XENLA A) Xenopus laevis (African clawed frog) 509 84.00% ARP33101_P050 Q68F04_XENLA MGC83247 protein Xenopus laevis (African clawed frog) 823 85.00% Xenopus tropicalis (Western clawed frog) ARP33101_P050 B4F6N7_XENTR Putative uncharacterized protein (Silurana tropicalis) 861 85.00% Cerebellar degeneration‐related protein 2, Xenopus tropicalis (Western clawed frog) Cdr2l ARP51161_T100 Q6GL55_XENTR 62kDa (Silurana tropicalis) 445 92.00% Cdr2l ARP51161_T100 Q68EY4_XENLA MGC84059 protein Xenopus laevis (African clawed frog) 178 92.00% mkxa ARP31887_P050 Q6DDN0_XENLA MGC82772 protein Xenopus laevis (African clawed frog) 358 100.00% hnrnpd ARP40238_T100 Q645K2_XENLA P37 AUF1 Xenopus laevis (African clawed frog) 295 85.00% Xenopus tropicalis (Western clawed frog) hnrnpd ARP40238_T100 Q537I0_XENTR AUF1 (Silurana tropicalis) 295 85.00% hnrnpd ARP40238_T100 Q4V7K8_XENLA LOC496375 protein Xenopus laevis (African clawed frog) 286 85.00% ORF Names:ACLA_035660 EMBL EAW09363.1OrganismAspergillus clavatus ARP46927_P050 Q6DDK6_XENLA Alg6‐prov protein Xenopus laevis (African clawed frog) 506 92.00%

ORF Names:ACLA_035660 EMBL Asparagine‐linked glycosylation 6 homolog EAW09363.1OrganismAspergillus (Yeast, alpha‐1,3‐glucosyltransferase) Xenopus tropicalis (Western clawed frog) clavatus ARP46927_P050 Q5I096_XENTR (Hypothetical LOC496948) (Silurana tropicalis) 506 92.00% ORF Names:ACLA_035660 EMBL EAW09363.1OrganismAspergillus clavatus ARP46927_P050 A4FVF3_XENLA LOC100049135 protein Xenopus laevis (African clawed frog) 506 92.00% ORF Names:GSPATT00012749001 EMBL CAK77241.1OrganismParamecium Peptidyl‐prolyl cis‐trans isomerase B tetraurelia ARP44364_P050 Q98UE5_XENLA (Fragment) Xenopus laevis (African clawed frog) 104 92.00% ORF Names:GSPATT00012749001 EMBL CAK77241.1OrganismParamecium tetraurelia ARP44364_P050 Q7SZ26_XENLA Ppib‐prov protein Xenopus laevis (African clawed frog) 216 92.00% ORF Names:GSPATT00012749001 EMBL CAK77241.1OrganismParamecium tetraurelia ARP44364_P050 Q5XGR3_XENLA LOC495270 protein Xenopus laevis (African clawed frog) 216 92.00% ORF Names:GSPATT00012749001 EMBL CAK77241.1OrganismParamecium Xenopus tropicalis (Western clawed frog) tetraurelia ARP44364_P050 Q28G13_XENTR Peptidylprolyl isomerase B (Cyclophilin B) (Silurana tropicalis) 208 92.00% ORF Names:GSPATT00012749001 EMBL CAK77241.1OrganismParamecium tetraurelia ARP44364_P050 Q3KPU5_XENLA LOC733374 protein (Fragment) Xenopus laevis (African clawed frog) 215 85.00% ARP54714_P050 Q66IR9_XENLA LOC446944 protein (Fragment) Xenopus laevis (African clawed frog) 528 85.00% ARP54714_P050 Q4KLE2_XENLA LOC446944 protein (Fragment) Xenopus laevis (African clawed frog) 479 85.00% ARP54714_P050 A2RV52_XENLA Putative uncharacterized protein Xenopus laevis (African clawed frog) 628 85.00% ARP54714_P050 Q7T0S6_XENLA LOC398692 protein Xenopus laevis (African clawed frog) 590 84.00% ARP54714_P050 Q6DCG7_XENLA Putative uncharacterized protein Xenopus laevis (African clawed frog) 587 84.00% ARP54714_P050 Q6GN80_XENLA Gbp2 protein Xenopus laevis (African clawed frog) 595 76.00% Novel protein similar to guanylate binding Xenopus tropicalis (Western clawed frog) ARP54714_P050 Q28D39_XENTR protein 4 (Silurana tropicalis) 595 76.00% Xenopus tropicalis (Western clawed frog) ARP54714_P050 Q0IJ14_XENTR Putative uncharacterized protein MGC145306 (Silurana tropicalis) 591 76.00% Xenopus tropicalis (Western clawed frog) ARP54714_P050 B1WBJ6_XENTR LOC100145795 protein (Silurana tropicalis) 628 78.00% Xenopus tropicalis (Western clawed frog) ARP54714_P050 B1H123_XENTR LOC100145295 protein (Silurana tropicalis) 432 76.00% ARP54714_P050 A2VD69_XENLA LOC100037176 protein Xenopus laevis (African clawed frog) 611 76.00%

General transcription factor II‐I repeat domain‐ containing protein 1 (Binding factor for early enhancer) (BEN) (XBEN) (GTF2I repeat domain‐ containing protein 1) (Williams‐Beuren syndrome critical region 11‐like protein) gtf2ird1 ARP33735_T100 GT2D1_XENLA (XWBSCR11) Xenopus laevis (African clawed frog) 993 78.00% ORF Names:GSPATT00037598001 EMBL CAK69161.1OrganismParamecium Enoyl Coenzyme A hydratase, short chain, 1, Xenopus tropicalis (Western clawed frog) tetraurelia ARP45698_P050 Q6GLG0_XENTR mitochondrial (Silurana tropicalis) 286 92.00% ORF Names:GSPATT00037598001 EMBL CAK69161.1OrganismParamecium tetraurelia ARP45698_P050 Q2VPL7_XENLA LOC733431 protein (Fragment) Xenopus laevis (African clawed frog) 285 92.00% ORF Names:GSPATT00037598001 EMBL CAK69161.1OrganismParamecium tetraurelia ARP45698_P050 Q05AV8_XENLA LOC733431 protein Xenopus laevis (African clawed frog) 175 92.00% Xenopus tropicalis (Western clawed frog) Kat5 ARP32488_P050 Q0IJ11_XENTR Putative uncharacterized protein MGC145349 (Silurana tropicalis) 506 92.00% Xenopus tropicalis (Western clawed frog) Kat5 ARP32488_P050 B1H0Y6_XENTR MGC145349 protein (Silurana tropicalis) 505 92.00%

Ordered Locus Names:Bcen2424_3966OrganismBurkh Cystathionase (Cystathionine gamma‐lyase) Xenopus tropicalis (Western clawed frog) olderia cenocepacia (strain HI2424) ARP46068_T100 Q6P849_XENTR (Putative uncharacterized protein MGC75946) (Silurana tropicalis) 398 85.00%

Ordered Locus Names:Bcen2424_3966OrganismBurkh olderia cenocepacia (strain HI2424) ARP46068_T100 Q640H4_XENLA LOC494673 protein Xenopus laevis (African clawed frog) 398 85.00% ptprr ARP44901_P050 Q7SZ04_XENLA LOC398636 protein (Fragment) Xenopus laevis (African clawed frog) 500 100.00% ptprr ARP44901_P050 Q561L4_XENLA Putative uncharacterized protein (Fragment) Xenopus laevis (African clawed frog) 447 100.00% Xenopus tropicalis (Western clawed frog) ptprr ARP44901_P050 A4IJ13_XENTR LOC100125100 protein (Silurana tropicalis) 656 100.00% Esd ARP58619_P050 Q66KU0_XENLA MGC85439 protein Xenopus laevis (African clawed frog) 282 84.00% Esd ARP58619_P050 Q642Q6_XENLA MGC84363 protein Xenopus laevis (African clawed frog) 282 84.00% Xenopus tropicalis (Western clawed frog) Esd ARP58619_P050 Q5M8U4_XENTR Hypothetical LOC496692 (Silurana tropicalis) 282 84.00% Nr4a2 ARP32730_P050 Q7T0V3_XENLA Nr4a1 protein Xenopus laevis (African clawed frog) 577 100.00% Nr4a2 ARP32730_P050 Q6INY4_XENLA Nr4a1‐A protein Xenopus laevis (African clawed frog) 577 100.00% Nuclear receptor subfamily 4, group A, Xenopus tropicalis (Western clawed frog) Nr4a2 ARP32730_P050 Q0V9X8_XENTR member 1 (Silurana tropicalis) 577 100.00% Nuclear receptor subfamily 4 group A member Xenopus tropicalis (Western clawed frog) Nr4a2 ARP32730_P050 NR4A2_XENTR 2 (Silurana tropicalis) 591 100.00% Nuclear receptor subfamily 4 group A member 1 (Nerve growth factor‐induced protein I‐B Nr4a2 ARP32730_P050 NR4A1_XENLA homolog) Xenopus laevis (African clawed frog) 577 100.00% Xenopus tropicalis (Western clawed frog) ARP49471_P050 B3DLC7_XENTR LOC100170484 protein (Silurana tropicalis) 725 84.00% Rabggtb ARP48634_P050 Q5EAU8_XENLA MGC85147 protein Xenopus laevis (African clawed frog) 331 92.00% Xenopus tropicalis (Western clawed frog) Rabggtb ARP48634_P050 A9JTX7_XENTR LOC100127877 protein (Silurana tropicalis) 331 92.00% Xenopus tropicalis (Western clawed frog) NAP1‐like ARP34131_P050 Q0P4K9_XENTR Rcor3 protein (Fragment) (Silurana tropicalis) 456 100.00%

LIM homeobox transcription factor 1‐beta.1 .2 ARP38140_T100 LMX1B_XENLA (LIM homeobox protein 1b) (Xlmx1b) Xenopus laevis (African clawed frog) 400 92.00% ARP56243_P050 Q6P7I7_XENLA Sar1a‐prov protein Xenopus laevis (African clawed frog) 198 100.00% Xenopus tropicalis (Western clawed frog) ARP56243_P050 Q5CZL6_XENTR MGC108053 protein (Silurana tropicalis) 198 100.00% SAR1a gene homolog 1 (S. cerevisiae) (SAR1a Xenopus tropicalis (Western clawed frog) ARP56243_P050 Q6P4X3_XENTR protein) (Sar1a‐prov protein) (Silurana tropicalis) 198 100.00% ARP56243_P050 Q66J32_XENLA MGC82076 protein Xenopus laevis (African clawed frog) 198 100.00% ORF Names:ACLA_092270 EMBL EAW11529.1OrganismAspergillus clavatus ARP51987_P050 Q9PUI2_XENLA CKIe protein (Casein kinase I epsilon) Xenopus laevis (African clawed frog) 416 100.00% ORF Names:ACLA_092270 EMBL EAW11529.1OrganismAspergillus Xenopus tropicalis (Western clawed frog) clavatus ARP51987_P050 Q5XGI6_XENTR Casein kinase 1, epsilon (Silurana tropicalis) 416 100.00% ORF Names:ACLA_092270 EMBL EAW11529.1OrganismAspergillus clavatus ARP51987_P050 KC1D_XENLA Isoform 2 Xenopus laevis (African clawed frog) 358 92.00% ORF Names:ACLA_092270 EMBL EAW11529.1OrganismAspergillus Casein kinase I isoform delta (CKI‐delta) (CKId) Xenopus tropicalis (Western clawed frog) clavatus ARP51987_P050 KC1D_XENTR (EC 2.7.11.1) (Silurana tropicalis) 415 92.00% ORF Names:ACLA_092270 EMBL EAW11529.1OrganismAspergillus Casein kinase I isoform delta (CKI‐delta) (CKId) clavatus ARP51987_P050 KC1D_XENLA (EC 2.7.11.1) Xenopus laevis (African clawed frog) 415 92.00% DKEY‐85K8.3 ARP56231_P050 Q6AZV4_XENLA MGC78845 protein Xenopus laevis (African clawed frog) 224 100.00% DKEY‐85K8.3 ARP56231_P050 Q6AZT1_XENLA MGC81677 protein Xenopus laevis (African clawed frog) 234 100.00% Xenopus tropicalis (Western clawed frog) DKEY‐85K8.3 ARP56231_P050 Q68FB7_XENTR Splicing factor, arginine/serine‐rich 7, 35kDa (Silurana tropicalis) 234 100.00% Eukaryotic translation initiation factor 3 subunit E (eIF3e) (Eukaryotic translation Xenopus tropicalis (Western clawed frog) ARP48176_P050 EIF3E_XENTR initiation factor 3 subunit 6) (Silurana tropicalis) 446 100.00%

Eukaryotic translation initiation factor 3 subunit E‐B (eIF3e‐B) (Eukaryotic translation ARP48176_P050 EI3EB_XENLA initiation factor 3 subunit 6‐B) Xenopus laevis (African clawed frog) 446 100.00%

Eukaryotic translation initiation factor 3 subunit E‐A (eIF3e‐A) (Eukaryotic translation ARP48176_P050 EI3EA_XENLA initiation factor 3 subunit 6‐A) Xenopus laevis (African clawed frog) 446 100.00%

ORF SWI/SNF related, matrix associated, actin Names:v1g200763OrganismNematostel dependent regulator of chromatin, subfamily Xenopus tropicalis (Western clawed frog) la vectensis (Starlet sea anemone) ARP38223_P050 Q6GL18_XENTR d, member 1 (Silurana tropicalis) 508 85.00%

ORF SWI/SNF related, matrix associated, actin Names:v1g200763OrganismNematostel dependent regulator of chromatin, subfamily Xenopus tropicalis (Western clawed frog) la vectensis (Starlet sea anemone) ARP38223_P050 Q28CT6_XENTR d, member 1 (Silurana tropicalis) 508 85.00%

ORF Names:v1g200763OrganismNematostel la vectensis (Starlet sea anemone) ARP38223_P050 Q7ZXG1_XENLA Smarcd1 protein (Fragment) Xenopus laevis (African clawed frog) 481 85.00%

ORF Names:v1g200763OrganismNematostel la vectensis (Starlet sea anemone) ARP38223_P050 Q6DCP7_XENLA Smarcd1 protein (Fragment) Xenopus laevis (African clawed frog) 513 85.00%

ORF Names:v1g200763OrganismNematostel la vectensis (Starlet sea anemone) ARP38223_P050 Q66J25_XENLA Smarcd1 protein (Fragment) Xenopus laevis (African clawed frog) 504 85.00%

ORF Names:v1g200763OrganismNematostel la vectensis (Starlet sea anemone) ARP38223_P050 Q505N3_XENLA Smarcd1 protein (Fragment) Xenopus laevis (African clawed frog) 496 85.00%

ORF Names:v1g200763OrganismNematostel la vectensis (Starlet sea anemone) ARP38223_P050 A1A5J8_XENLA Smarcd1 protein Xenopus laevis (African clawed frog) 507 85.00% SOX2 ARP31737_P050 D2WK21_XENLA Sex‐determining region Y‐box 2 Xenopus laevis (African clawed frog) 311 91.00% Transcription factor Sox‐2 (SRY (sex Xenopus tropicalis (Western clawed frog) SOX2 ARP31737_P050 SOX2_XENTR determining region Y)‐box 2) (Silurana tropicalis) 311 91.00%

Transcription factor Sox‐2 (XSox2) (XlSox‐2) SOX2 ARP31737_P050 SOX2_XENLA (SRY (sex determining region Y)‐box 2) Xenopus laevis (African clawed frog) 311 91.00%

ARP42671_P050 Q7ZXU8_XENLA Asc1p100 protein (Asc1p100‐prov protein) Xenopus laevis (African clawed frog) 731 100.00% Activating signal cointegrator 1 complex Xenopus tropicalis (Western clawed frog) ARP42671_P050 Q28DS1_XENTR subunit 2 (Silurana tropicalis) 734 100.00% Potassium voltage‐gated channel KQT‐like Xenopus tropicalis (Western clawed frog) KCNQ ARP35458_P050 Q0P4Q9_XENTR protein 4 (Silurana tropicalis) 606 85.00% zfpm1 ARP32193_P050 D3Y1C0_XENLA Friend of GATA Xenopus laevis (African clawed frog) 1186 90.00% Zinc finger protein FOG (Friend of GATA) zfpm1 ARP32193_P050 FOG1_XENLA (xFOG) (Fragment) Xenopus laevis (African clawed frog) 1061 90.00% ARP42107_P050 Q52M97_XENLA Putative uncharacterized protein Xenopus laevis (African clawed frog) 368 78.00%

Ordered Locus Names:Bcen2424_4815OrganismBurkh Diacetyl/L‐xylulose reductase (Dicarbonyl/L‐ Xenopus tropicalis (Western clawed frog) olderia cenocepacia (strain HI2424) ARP42462_P050 Q6P630_XENTR xylulose reductase) (Silurana tropicalis) 244 85.00%

Ordered Locus Names:Bcen2424_4815OrganismBurkh olderia cenocepacia (strain HI2424) ARP42462_P050 Q4QR61_XENLA MGC114658 protein Xenopus laevis (African clawed frog) 244 85.00% Xenopus tropicalis (Western clawed frog) NeuroD ARP32415_P050 B4F715_XENTR Neurod4 protein (Silurana tropicalis) 316 92.00%

Neurogenic differentiation factor 4 (NeuroD4) (Helix‐loop‐helix protein xATH‐3) (xATH3) NeuroD ARP32415_P050 NDF4_XENLA (Protein atonal homolog 3) Xenopus laevis (African clawed frog) 315 85.00% NeuroD ARP32415_P050 Q6GPW1_XENLA MGC82572 protein Xenopus laevis (African clawed frog) 357 76.00% Xenopus tropicalis (Western clawed frog) NeuroD ARP32415_P050 Q4JF54_XENTR NeuroD1 (Neurod1 protein) (Silurana tropicalis) 361 76.00%

NeuroD ARP32415_P050 NDF1_XENLA Neurogenic differentiation factor 1 (NeuroD1) Xenopus laevis (African clawed frog) 352 76.00% Xenopus tropicalis (Western clawed frog) NeuroD ARP32415_P050 Q0P4T4_XENTR Neurogenic differentiation 2 (Silurana tropicalis) 353 76.00%

Mannose‐1‐phosphate guanyltransferase alpha (EC 2.7.7.13) (GDP‐mannose pyrophosphorylase A) (GTP‐mannose‐1‐ Xenopus tropicalis (Western clawed frog) ARP49209_P050 GMPPA_XENTR phosphate guanylyltransferase alpha) (Silurana tropicalis) 421 100.00% Mannose‐1‐phosphate guanyltransferase alpha‐B (EC 2.7.7.13) (GDP‐mannose pyrophosphorylase A‐B) (GTP‐mannose‐1‐ ARP49209_P050 GMPAB_XENLA phosphate guanylyltransferase apha‐B) Xenopus laevis (African clawed frog) 426 100.00% Mannose‐1‐phosphate guanyltransferase alpha‐A (EC 2.7.7.13) (GDP‐mannose pyrophosphorylase A‐A) (GTP‐mannose‐1‐ phosphate guanylyltransferase subunit alpha‐ ARP49209_P050 GMPAA_XENLA A) Xenopus laevis (African clawed frog) 421 100.00% Fubp3 ARP37732_T100 Q8AX84_XENLA FUSE binding protein‐like protein Xenopus laevis (African clawed frog) 610 100.00% Fubp3 ARP37732_T100 Q7ZXS1_XENLA Fubp1 protein Xenopus laevis (African clawed frog) 653 100.00% Far upstream element (FUSE) binding protein Xenopus tropicalis (Western clawed frog) Fubp3 ARP37732_T100 Q6P3Q5_XENTR 1 (Silurana tropicalis) 653 100.00% MGC78835 protein (Putative uncharacterized Fubp3 ARP37732_T100 Q6IRB9_XENLA protein MGC78835) Xenopus laevis (African clawed frog) 653 100.00% Xenopus tropicalis (Western clawed frog) Fubp3 ARP37732_T100 Q28BR2_XENTR OTTXETP00000007035 (Silurana tropicalis) 653 100.00% Fubp3 ARP37732_T100 Q6PAA0_XENLA MGC68532 protein Xenopus laevis (African clawed frog) 546 85.00% Xenopus tropicalis (Western clawed frog) Fubp3 ARP37732_T100 A4IH51_XENTR Fubp3 protein (Silurana tropicalis) 546 85.00% CBX2 ARP51628_P050 Q9YHC4_XENLA Pc1 protein (Polycomb homolog Pc1) Xenopus laevis (African clawed frog) 471 76.00% si:ch211‐130m23.3 ARP31828_P050 Q7ZYQ7_XENLA Ssbp2‐prov protein Xenopus laevis (African clawed frog) 359 92.00% si:ch211‐130m23.3 ARP31828_P050 Q6NRV5_XENLA Ssbp2‐prov protein Xenopus laevis (African clawed frog) 387 92.00% Xenopus tropicalis (Western clawed frog) si:ch211‐130m23.3 ARP31828_P050 B4F6X9_XENTR Putative uncharacterized protein (Silurana tropicalis) 387 92.00% col1a2 ARP58441_P050 Q801M5_XENLA Col1a2‐prov protein Xenopus laevis (African clawed frog) 1346 78.00% Xenopus tropicalis (Western clawed frog) col1a2 ARP58441_P050 A0JM00_XENTR Collagen, type 1, alpha 2 (Silurana tropicalis) 1354 78.00% si:dkeyp‐35f11.3 ARP32444_P050 B7ZPU9_XENLA Xlim‐3 protein Xenopus laevis (African clawed frog) 395 100.00%

LIM/homeobox protein Lhx3 (LIM homeobox si:dkeyp‐35f11.3 ARP32444_P050 LHX3_XENLA protein 3) (Homeobox protein LIM‐3) (xLIM‐3) Xenopus laevis (African clawed frog) 395 100.00% Receptor‐associated protein of the Rapsn ARP43045_P050 Q9IAX5_XENLA (Fragment) Xenopus laevis (African clawed frog) 359 92.00% Rapsn ARP43045_P050 Q6GNS2_XENLA Rapsn protein Xenopus laevis (African clawed frog) 320 92.00% Receptor‐associated protein of the synapse, Xenopus tropicalis (Western clawed frog) Rapsn ARP43045_P050 Q6GL21_XENTR 43kD (Silurana tropicalis) 412 92.00%

Forkhead box protein I1‐ema (FoxI1‐ema) (Ectodermally‐expressed mesendoderm FOXI1 ARP38963_P050 FXI1E_XENLA antagonist) (Xema) (FoxI3) Xenopus laevis (African clawed frog) 373 78.00% Forkhead box protein I1‐ema (FoxI1‐ema) (Ectodermally‐expressed mesendoderm Xenopus tropicalis (Western clawed frog) FOXI1 ARP38963_P050 FXI1E_XENTR antagonist) (FoxI3) (Silurana tropicalis) 373 90.00% ORF Names:GSPATT00014252001 EMBL CAK79285.1OrganismParamecium tetraurelia ARP55917_P050 Q6P412_XENLA MGC68722 protein Xenopus laevis (African clawed frog) 143 100.00% ORF Names:GSPATT00014252001 EMBL CAK79285.1OrganismParamecium Xenopus tropicalis (Western clawed frog) tetraurelia ARP55917_P050 Q28GQ5_XENTR RAB15, member RAS onocogene family (Silurana tropicalis) 212 100.00% ORF Names:GSPATT00014252001 EMBL CAK79285.1OrganismParamecium tetraurelia ARP55917_P050 Q7ZYB8_XENLA Rab3d protein (Fragment) Xenopus laevis (African clawed frog) 246 78.00% ORF Names:GSPATT00014252001 EMBL CAK79285.1OrganismParamecium tetraurelia ARP55917_P050 Q6GLK0_XENLA MGC84786 protein Xenopus laevis (African clawed frog) 217 78.00% ORF Names:GSPATT00014252001 EMBL CAK79285.1OrganismParamecium Xenopus tropicalis (Western clawed frog) tetraurelia ARP55917_P050 Q6GLB1_XENTR RAB3D, member RAS oncogene family (Silurana tropicalis) 216 78.00% ORF Names:GSPATT00014252001 EMBL CAK79285.1OrganismParamecium tetraurelia ARP55917_P050 Q640G6_XENLA LOC494677 protein Xenopus laevis (African clawed frog) 217 78.00% ORF Names:GSPATT00014252001 EMBL CAK79285.1OrganismParamecium tetraurelia ARP55917_P050 Q5U507_XENLA Rab3a‐prov protein Xenopus laevis (African clawed frog) 220 78.00% ORF Names:GSPATT00014252001 EMBL CAK79285.1OrganismParamecium tetraurelia ARP55917_P050 Q3KQA5_XENLA Rab3d protein Xenopus laevis (African clawed frog) 217 78.00% ORF Names:GSPATT00014252001 EMBL CAK79285.1OrganismParamecium Xenopus tropicalis (Western clawed frog) tetraurelia ARP55917_P050 Q28H43_XENTR RAB3A, member RAS oncogene family (Silurana tropicalis) 220 78.00% ORF Names:GSPATT00014252001 EMBL CAK79285.1OrganismParamecium Xenopus tropicalis (Western clawed frog) tetraurelia ARP55917_P050 A4IH29_XENTR Rab3b protein (Silurana tropicalis) 217 78.00% P100830_T100 HOX3_XENLA Homeobox protein XHOX‐3 Xenopus laevis (African clawed frog) 388 91.00% ARP48923_P050 Q6GPD4_XENLA MGC80481 protein Xenopus laevis (African clawed frog) 837 76.00%

ORF Names:LACBIDRAFT_301859 EMBL EDR15471.1OrganismLaccaria bicolor (strain S238N‐H82) (Bicoloured deceiver) (Laccaria laccata var. bicolor) ARP40927_T100 Q6AZU2_XENLA LOC398218 protein Xenopus laevis (African clawed frog) 405 100.00%

ORF Names:LACBIDRAFT_301859 EMBL EDR15471.1OrganismLaccaria bicolor (strain S238N‐H82) (Bicoloured Xenopus tropicalis (Western clawed frog) deceiver) (Laccaria laccata var. bicolor) ARP40927_T100 Q28EL7_XENTR DAZ associated protein 1 (Silurana tropicalis) 347 100.00% Xenopus tropicalis (Western clawed frog) LOC549411 ARP44695_T100 A9JTS2_XENTR LOC100127838 protein (Silurana tropicalis) 176 92.00% Xenopus tropicalis (Western clawed frog) LOC549411 ARP44695_T100 A4IGX7_XENTR Putative uncharacterized protein LOC549411 (Silurana tropicalis) 171 84.00% Meis2 ARP38149_P050 P79939_XENLA XMeis1‐3 protein (Fragment) Xenopus laevis (African clawed frog) 137 100.00% Meis2 ARP38149_P050 B7ZRS8_XENLA Meis1 protein Xenopus laevis (African clawed frog) 465 92.00% Meis2 ARP38149_P050 MEIS1_XENLA Isoform 2 (Isoform XMeis1‐2) (Isoform b) Xenopus laevis (African clawed frog) 465 92.00% Meis2 ARP38149_P050 MEIS1_XENLA Homeobox protein Meis1 (XMeis1) Xenopus laevis (African clawed frog) 390 92.00% Xenopus tropicalis (Western clawed frog) Meis2 ARP38149_P050 A0JPD2_XENTR Meis2 protein (Silurana tropicalis) 368 85.00% Meis2 ARP38149_P050 MEI3A_XENLA Isoform 2 Xenopus laevis (African clawed frog) 385 85.00% Xenopus tropicalis (Western clawed frog) Meis2 ARP38149_P050 MEIS3_XENTR Homeobox protein meis3 (Silurana tropicalis) 453 85.00% Meis2 ARP38149_P050 MEI3B_XENLA Homeobox protein meis3‐B Xenopus laevis (African clawed frog) 451 85.00% Meis2 ARP38149_P050 MEI3A_XENLA Homeobox protein meis3‐A (XMeis3) Xenopus laevis (African clawed frog) 453 85.00% RNF5 ARP43414_P050 Q6GLU1_XENLA MGC84239 protein Xenopus laevis (African clawed frog) 189 92.00% Xenopus tropicalis (Western clawed frog) RNF5 ARP43414_P050 Q6GL83_XENTR MGC69334 protein (Silurana tropicalis) 144 92.00% RNF5 ARP43414_P050 Q5XGX4_XENLA LOC495261 protein Xenopus laevis (African clawed frog) 189 92.00% Xenopus tropicalis (Western clawed frog) RNF5 ARP43414_P050 Q28I91_XENTR Ring finger protein 125 (Silurana tropicalis) 189 92.00% RNF5 ARP43414_P050 Q5HZF5_XENLA LOC733145 protein (Fragment) Xenopus laevis (African clawed frog) 167 84.00% RNF5 ARP43414_P050 Q0D259_XENLA LOC733145 protein (Fragment) Xenopus laevis (African clawed frog) 186 84.00% Xenopus tropicalis (Western clawed frog) RNF5 ARP43414_P050 Q07G61_XENTR Ring finger protein 5 (Silurana tropicalis) 168 84.00% RNF5 ARP43414_P050 A5D8L1_XENLA LOC100049739 protein Xenopus laevis (African clawed frog) 168 84.00% Xenopus tropicalis (Western clawed frog) Nfyc ARP39066_P050 Q6P4L4_XENTR Nuclear transcription factor Y, gamma (Silurana tropicalis) 334 100.00% Nfyc ARP39066_P050 Q6DCR1_XENLA Putative uncharacterized protein Xenopus laevis (African clawed frog) 332 100.00% Nuclear Y/CCAAT‐box binding factor C subunit Nfyc ARP39066_P050 O73745_XENLA NF‐YC Xenopus laevis (African clawed frog) 330 100.00% LOC100127321 protein (Putative Nfyc ARP39066_P050 A9JS66_XENLA uncharacterized protein LOC100127321) Xenopus laevis (African clawed frog) 331 100.00% Xenopus tropicalis (Western clawed frog) Gbeta1 ARP48278_P050 B3DLQ7_XENTR LOC100170528 protein (Silurana tropicalis) 340 78.00% ELK4 P100832_T100 Q6DDF1_XENLA Gabpa‐prov protein Xenopus laevis (African clawed frog) 452 100.00% ELK4 P100832_T100 Q498G8_XENLA Putative uncharacterized protein Xenopus laevis (African clawed frog) 454 100.00% Xenopus tropicalis (Western clawed frog) ELK4 P100832_T100 B1WAQ8_XENTR Gabpa protein (Silurana tropicalis) 454 100.00% ELK4 P100832_T100 Q91744_XENLA XE1‐a protein (Fragment) Xenopus laevis (African clawed frog) 268 85.00% ELK4 P100832_T100 Q6DJL5_XENLA C‐ets‐1b protein Xenopus laevis (African clawed frog) 439 85.00% ELK4 P100832_T100 Q6DE76_XENLA LOC397877 protein Xenopus laevis (African clawed frog) 472 85.00% Xenopus tropicalis (Western clawed frog) ELK4 P100832_T100 B3DM35_XENTR LOC100170599 protein (Silurana tropicalis) 438 85.00% Xenopus tropicalis (Western clawed frog) ELK4 P100832_T100 B1WAP2_XENTR LOC100145687 protein (Silurana tropicalis) 471 85.00% ELK4 P100832_T100 A2RV55_XENLA Ets2a‐A protein Xenopus laevis (African clawed frog) 472 85.00% ELK4 P100832_T100 A1L2V8_XENLA Ets1a‐a protein Xenopus laevis (African clawed frog) 438 85.00% ELK4 P100832_T100 ETS2B_XENLA Protein c‐ets‐2‐B (C‐ets‐2B) Xenopus laevis (African clawed frog) 472 85.00% ELK4 P100832_T100 ETS2A_XENLA Protein c‐ets‐2‐A (C‐ets‐2A) Xenopus laevis (African clawed frog) 472 85.00% Protein c‐ets‐1‐B (C‐ets‐1B) (XE1‐B) ELK4 P100832_T100 ETS1B_XENLA (Fragment) Xenopus laevis (African clawed frog) 268 85.00% ELK4 P100832_T100 ETS1A_XENLA Protein c‐ets‐1‐A (C‐ets‐1A) Xenopus laevis (African clawed frog) 438 85.00% ELK4 P100832_T100 Q4KLQ2_XENLA MGC115679 protein Xenopus laevis (African clawed frog) 369 85.00% Xenopus tropicalis (Western clawed frog) ELK4 P100832_T100 B0JZY8_XENTR Ets1 protein (Silurana tropicalis) 243 85.00% ELK4 P100832_T100 Q98SI4_XENLA Ternary complex factor XSAP1 Xenopus laevis (African clawed frog) 406 83.00% ELK4 P100832_T100 Q6GM77_XENLA MGC82106 protein Xenopus laevis (African clawed frog) 405 83.00% CBFA2T1 ARP58127_P050 Q5IJ72_XENLA MTG8 Xenopus laevis (African clawed frog) 582 92.00% Xenopus tropicalis (Western clawed frog) Fgf2 ARP42005_P050 Q28DZ3_XENTR Fibroblast growth factor 2 (Basic) (Silurana tropicalis) 154 85.00% Fgf2 ARP42005_P050 B7ZPK6_XENLA Fibroblast growth factor 2 (Basic) Xenopus laevis (African clawed frog) 155 85.00% Heparin‐binding growth factor 2 (HBGF‐2) Fgf2 ARP42005_P050 FGF2_XENLA (Basic fibroblast growth factor) (bFGF) Xenopus laevis (African clawed frog) 155 85.00% LOC100036803 ARP55352_P050 A0JPI2_XENLA LOC100036803 protein Xenopus laevis (African clawed frog) 467 84.00%

MAP kinase‐interacting serine/threonine‐ protein kinase 2 (EC 2.7.11.1) (MAP kinase Xenopus tropicalis (Western clawed frog) LOC100036803 ARP55352_P050 MKNK2_XENTR signal‐integrating kinase 2) (Mnk2) (Silurana tropicalis) 466 91.00%

MAP kinase‐interacting serine/threonine‐ protein kinase 2 (EC 2.7.11.1) (MAP kinase LOC100036803 ARP55352_P050 MKNK2_XENLA signal‐integrating kinase 2) (Mnk2) Xenopus laevis (African clawed frog) 467 83.00% Glycine amidinotransferase, mitochondrial (EC ORF Names:BGP_5484 EMBL 2.1.4.1) (L‐arginine:glycine Xenopus tropicalis (Western clawed frog) EDN70597.1OrganismBeggiatoa sp. PS ARP48553_P050 GATM_XENTR amidinotransferase) (Transamidinase) (Silurana tropicalis) 422 100.00%

Glycine amidinotransferase, mitochondrial (EC ORF Names:BGP_5484 EMBL 2.1.4.1) (L‐arginine:glycine EDN70597.1OrganismBeggiatoa sp. PS ARP48553_P050 GATM_XENLA amidinotransferase) (Transamidinase) Xenopus laevis (African clawed frog) 422 100.00% ER degradation enhancer, mannosidase alpha‐ Xenopus tropicalis (Western clawed frog) edem1 ARP47054_P050 Q6P1U5_XENTR like 1 (Silurana tropicalis) 594 92.00% edem1 ARP47054_P050 A4QN34_XENLA LOC100049149 protein Xenopus laevis (African clawed frog) 595 92.00% Wingless‐type MMTV integration site family, Xenopus tropicalis (Western clawed frog) WNT‐5B ARP41280_T100 Q6DII0_XENTR member 5B (Silurana tropicalis) 360 85.00%

WNT‐5B ARP41280_T100 WNT5B_XENLA Protein Wnt‐5b (Protein Wnt‐5c) (XWnt‐5C) Xenopus laevis (African clawed frog) 360 85.00% Wingless‐type MMTV integration site family, WNT‐5B ARP41280_T100 B7ZQY1_XENLA member 5A Xenopus laevis (African clawed frog) 380 78.00% WNT‐5B ARP41280_T100 WNT5A_XENLA Protein Wnt‐5a (XWnt‐5a) Xenopus laevis (African clawed frog) 380 78.00% Ordered Locus Names:Acel_0388OrganismAcidotherm us cellulolyticus (strain ATCC 43068 / 11B) ARP48207_P050 Q7SYW4_XENLA Isocitrate dehydrogenase [NADP] (EC 1.1.1.42) Xenopus laevis (African clawed frog) 454 100.00% Ordered Locus Names:Acel_0388OrganismAcidotherm us cellulolyticus (strain ATCC 43068 / Xenopus tropicalis (Western clawed frog) 11B) ARP48207_P050 Q6GLF0_XENTR Isocitrate dehydrogenase [NADP] (EC 1.1.1.42) (Silurana tropicalis) 455 100.00% Pwp2 ARP45822_P050 Q4FZW8_XENLA MGC115367 protein Xenopus laevis (African clawed frog) 895 92.00% Xenopus tropicalis (Western clawed frog) Pwp2 ARP45822_P050 B2GUD6_XENTR LOC100158563 protein (Silurana tropicalis) 774 92.00% Xenopus tropicalis (Western clawed frog) Tlk1 ARP58340_P050 B0BM07_XENTR LOC100144941 protein (Fragment) (Silurana tropicalis) 225 92.00% Xenopus tropicalis (Western clawed frog) ARP40216_T100 RL8_XENTR 60S ribosomal protein L8 (Silurana tropicalis) 257 100.00% ARP40216_T100 RL8_XENLA 60S ribosomal protein L8 Xenopus laevis (African clawed frog) 257 100.00% ORF Names:CpipJ_CPIJ013077 EMBL EDS38506.1OrganismCulex quinquefasciatus (Southern house Xenopus tropicalis (Western clawed frog) mosquito) (Culex pungens) ARP38961_T100 B0JZ54_XENTR Foxb1 protein (Silurana tropicalis) 322 100.00% ORF Names:CpipJ_CPIJ013077 EMBL EDS38506.1OrganismCulex quinquefasciatus (Southern house Forkhead box protein B1 (FoxB1) mosquito) (Culex pungens) ARP38961_T100 FOXB1_XENLA (Transcription factor FKH‐5) Xenopus laevis (African clawed frog) 319 100.00% Xenopus tropicalis (Western clawed frog) GGCX ARP44340_P050 B1WAX4_XENTR Ggcx protein (Silurana tropicalis) 749 85.00% GGCX ARP44340_P050 Q6GME5_XENLA MGC81803 protein Xenopus laevis (African clawed frog) 745 78.00% GGCX ARP44340_P050 Q5M7A9_XENLA MGC81803 protein Xenopus laevis (African clawed frog) 502 78.00% Xenopus tropicalis (Western clawed frog) ARP44126_P050 B5DEC2_XENTR Putative uncharacterized protein (Silurana tropicalis) 320 78.00% ORF Names:CpipJ_CPIJ007880 EMBL EDS30423.1OrganismCulex quinquefasciatus (Southern house Xenopus tropicalis (Western clawed frog) mosquito) (Culex pungens) ARP51956_P050 B5DE05_XENTR Putative uncharacterized protein (Silurana tropicalis) 391 100.00% ORF Names:CpipJ_CPIJ007880 EMBL EDS30423.1OrganismCulex quinquefasciatus (Southern house Diphthamide biosynthesis protein 1 (DPH1 mosquito) (Culex pungens) ARP51956_P050 DPH1_XENLA homolog) Xenopus laevis (African clawed frog) 439 92.00% TH AVARP01052_P050 A1KXR0_XENLA Xenopus laevis (African clawed frog) 489 100.00% Mrto4 ARP46240_T100 Q7SZU0_XENLA MGC68920 protein Xenopus laevis (African clawed frog) 240 100.00% Xenopus tropicalis (Western clawed frog) Mrto4 ARP46240_T100 Q6DEP1_XENTR MGC89995 protein (Novel protein) (Silurana tropicalis) 240 100.00% Hist1h3e ARP46041_P050 Q92135_XENLA Histone H3 (Fragment) Xenopus laevis (African clawed frog) 78 76.00%

Xenopus laevis histone gene cluster Xlh1 with Hist1h3e ARP46041_P050 Q92134_XENLA H3, H4, H2B, H2A and H1B Xenopus laevis (African clawed frog) 76 76.00% Hist1h3e ARP46041_P050 Q92133_XENLA Histone H3 Xenopus laevis (African clawed frog) 136 76.00% Hist1h3e ARP46041_P050 Q92132_XENLA Histone H3 Xenopus laevis (African clawed frog) 136 76.00% Xenopus tropicalis (Western clawed frog) Hist1h3e ARP46041_P050 Q28FA2_XENTR H3 histone (Silurana tropicalis) 136 76.00% Xenopus tropicalis (Western clawed frog) Hist1h3e ARP46041_P050 B1H2B4_XENTR Hist2h3c protein (Silurana tropicalis) 136 76.00% Xenopus tropicalis (Western clawed frog) Hist1h3e ARP46041_P050 A9ULQ0_XENTR Putative uncharacterized protein (Silurana tropicalis) 136 76.00% Xenopus tropicalis (Western clawed frog) Hist1h3e ARP46041_P050 A9JTR4_XENTR H3f3b protein (MGC89877 protein) (Silurana tropicalis) 136 76.00% Xenopus tropicalis (Western clawed frog) ARP49710_P050 B1H1F6_XENTR Popeye domain containing 3 (Silurana tropicalis) 289 100.00% Xenopus tropicalis (Western clawed frog) ARP44945_P050 ACBD5_XENTR Acyl‐CoA‐binding domain‐containing protein 5 (Silurana tropicalis) 458 85.00%

ARP44945_P050 ACBD5_XENLA Acyl‐CoA‐binding domain‐containing protein 5 Xenopus laevis (African clawed frog) 467 78.00% Xenopus tropicalis (Western clawed frog) Snrk ARP56306_P050 B3DLY9_XENTR LOC100170575 protein (Silurana tropicalis) 764 85.00% ARP39757_P050 Q8UW66_XENLA P7E4 (Fragment) Xenopus laevis (African clawed frog) 229 92.00%

ARP39757_P050 Q5XGU7_XENLA BTB domain protein 3 (LOC495136 protein) Xenopus laevis (African clawed frog) 519 92.00% ARP39757_P050 A8E625_XENLA P7E4 protein (Fragment) Xenopus laevis (African clawed frog) 423 92.00% Xenopus tropicalis (Western clawed frog) ARP39757_P050 A1A5E8_XENTR LOC100036676 protein (Silurana tropicalis) 518 92.00% Xenopus tropicalis (Western clawed frog) ARP39757_P050 BTBD6_XENTR BTB/POZ domain‐containing protein 6 (Silurana tropicalis) 529 92.00% ARP39757_P050 BTBD6_XENLA BTB/POZ domain‐containing protein 6 Xenopus laevis (African clawed frog) 529 92.00% ARP55354_P050 Q801Q3_XENLA Ssbp3‐prov protein Xenopus laevis (African clawed frog) 391 92.00% Xenopus tropicalis (Western clawed frog) ARP55354_P050 Q6P4M2_XENTR Single stranded DNA binding protein 3 (Silurana tropicalis) 392 92.00% Xenopus tropicalis (Western clawed frog) ARP55354_P050 B4F6Z1_XENTR Ssbp3 protein (Silurana tropicalis) 391 92.00% Xenopus tropicalis (Western clawed frog) ARP55354_P050 A0JLY6_XENTR Ssbp3 protein (Silurana tropicalis) 396 92.00% ARP55354_P050 Q7ZX94_XENLA MGC53880 protein Xenopus laevis (African clawed frog) 387 85.00% Xenopus tropicalis (Western clawed frog) ARP55354_P050 Q28CH5_XENTR Single stranded DNA binding protein 3 (Silurana tropicalis) 358 84.00% sirt3 ARP32388_T100 Q5U250_XENLA Sir2 protein Xenopus laevis (African clawed frog) 413 84.00% Sirtuin (Silent mating type information Xenopus tropicalis (Western clawed frog) sirt3 ARP32388_T100 Q07FY7_XENTR regulation 2 homolog) 3 (S. cerevisiae) (Silurana tropicalis) 401 83.00%

ORF Names:zgc:114199 ZFIN ZDB‐GENE‐ 050913‐97OrganismDanio rerio Mesoderm induction early response protein 1 (Zebrafish) (Brachydanio rerio) ARP34468_T100 MIER1_XENLA (Early response 1) (Er1) (Mi‐er1) (Xmi‐er1) Xenopus laevis (African clawed frog) 495 100.00%

ORF Names:zgc:114199 ZFIN ZDB‐GENE‐ 050913‐97OrganismDanio rerio (Zebrafish) (Brachydanio rerio) ARP34468_T100 Q6DF88_XENLA LOC445833 protein (Fragment) Xenopus laevis (African clawed frog) 328 81.00% Tubulin polymerization‐promoting protein Xenopus tropicalis (Western clawed frog) tppp3 ARP42458_P050 TPPP3_XENTR family member 3 (Silurana tropicalis) 176 100.00% Tubulin polymerization‐promoting protein tppp3 ARP42458_P050 TPPP3_XENLA family member 3 Xenopus laevis (African clawed frog) 176 85.00% kcnq1 ARP34924_P050 B1N659_XENLA KvLQT‐1 Xenopus laevis (African clawed frog) 652 92.00% Xenopus tropicalis (Western clawed frog) kcnq1 ARP34924_P050 B1H1A7_XENTR LOC100145329 protein (Fragment) (Silurana tropicalis) 390 92.00%

Potassium voltage‐gated channel subfamily KQT member 1 (IKs producing slow voltage‐ gated potassium channel subunit alpha xKvLQT1) (KQT‐like 1) (Voltage‐gated kcnq1 ARP34924_P050 KCNQ1_XENLA potassium channel subunit Kv7.1) (Fragment) Xenopus laevis (African clawed frog) 377 92.00% Elongation factor Ts, mitochondrial (EF‐Ts) (EF‐ ARP38672_T100 EFTS_XENLA TsMt) Xenopus laevis (African clawed frog) 312 78.00% ARP32715_T100 Q8QHM1_XENLA Nuclear factor of activated T‐cell Xenopus laevis (African clawed frog) 884 83.00% ARP32715_T100 B7ZQA4_XENLA Nuclear factor of activated T‐cell Xenopus laevis (African clawed frog) 884 83.00% ARP32715_T100 B7ZQA2_XENLA Nuclear factor of activated T‐cell Xenopus laevis (African clawed frog) 884 83.00% Xenopus tropicalis (Western clawed frog) ARP32715_T100 B4F6V2_XENTR Putative uncharacterized protein (Silurana tropicalis) 894 83.00% Xenopus tropicalis (Western clawed frog) ARP45026_P050 B2GUG9_XENTR LOC100158586 protein (Silurana tropicalis) 738 78.00% FADS2 ARP42383_P050 Q6P422_XENLA MGC68735 protein Xenopus laevis (African clawed frog) 446 78.00% Xenopus tropicalis (Western clawed frog) FADS2 ARP42383_P050 B1H179_XENTR LOC100145314 protein (Silurana tropicalis) 429 78.00% ORF Names:LbrM22_V2.1080 EMBL CAM45166.1OrganismLeishmania Xenopus tropicalis (Western clawed frog) braziliensis ARP56183_P050 A9UL84_XENTR ChaC, cation transport regulator homolog 2 (Silurana tropicalis) 184 100.00% ORF Names:LbrM22_V2.1080 EMBL CAM45166.1OrganismLeishmania braziliensis ARP56183_P050 CHAC2_XENLA Cation transport regulator‐like protein 2 Xenopus laevis (African clawed frog) 184 100.00% ORF Names:OsI_18680 EMBL EAY96760.1OrganismOryza sativa Xenopus tropicalis (Western clawed frog) subsp. indica (Rice) ARP44427_T100 B0JZ44_XENTR Zfyve27 protein (Silurana tropicalis) 409 100.00% ORF Names:GSPATT00037053001 EMBL CAK68270.1OrganismParamecium tetraurelia ARP43157_T100 Q7ZXW4_XENLA Nmp200‐prov protein Xenopus laevis (African clawed frog) 504 78.00% ORF Names:GSPATT00037053001 EMBL CAK68270.1OrganismParamecium Xenopus tropicalis (Western clawed frog) tetraurelia ARP43157_T100 Q6GLG2_XENTR PRP19/PSO4 homolog (S. cerevisiae) (Silurana tropicalis) 439 78.00% ORF Names:GSPATT00037053001 EMBL CAK68270.1OrganismParamecium PRP19/PSO4 pre‐mRNA processing factor 19 Xenopus tropicalis (Western clawed frog) tetraurelia ARP43157_T100 Q28E36_XENTR homolog (S. cerevisiae) (Silurana tropicalis) 504 78.00% Nova1 ARP40398_P050 Q6GM36_XENLA MGC84002 protein Xenopus laevis (African clawed frog) 484 100.00% Xenopus tropicalis (Western clawed frog) Nova1 ARP40398_P050 A4II03_XENTR LOC100124925 protein (Silurana tropicalis) 508 100.00% Xenopus tropicalis (Western clawed frog) ARP48394_P050 Q6DK76_XENTR Mercaptopyruvate sulfurtransferase (Silurana tropicalis) 299 91.00% ARP48394_P050 Q6DFI3_XENLA Tst‐prov protein Xenopus laevis (African clawed frog) 299 91.00% ARP48394_P050 Q0VGW5_XENLA Mpst protein Xenopus laevis (African clawed frog) 299 91.00% LOC407241 ARP32587_T100 Q6YLV8_XENLA Krueppel‐like factor 15 Xenopus laevis (African clawed frog) 398 83.00% Xenopus tropicalis (Western clawed frog) elac1 ARP41347_P050 Q28FC0_XENTR Elac1 (Prov) (Silurana tropicalis) 363 85.00% ARP30175_P050 Q7ZX34_XENLA MGC52616 protein Xenopus laevis (African clawed frog) 670 90.00% Heat shock 70kDa protein 9 (Mortalin) (Heat Xenopus tropicalis (Western clawed frog) ARP30175_P050 Q6NVU3_XENTR shock 70kDa protein 9A) (Silurana tropicalis) 670 90.00% ARP30175_P050 B2L575_XENBO Heat shock protein 9 (Fragment) Xenopus borealis (Kenyan clawed frog) 110 90.00% LSM4 homolog, U6 small nuclear RNA Xenopus tropicalis (Western clawed frog) ARP40728_P050 Q6P334_XENTR associated (S. cerevisiae) (Silurana tropicalis) 138 83.00% ARP40728_P050 Q5U5A5_XENLA LOC495318 protein Xenopus laevis (African clawed frog) 138 83.00% ORF Names:GSPATT00020982001 EMBL CAK87340.1OrganismParamecium tetraurelia ARP58177_P050 Q7ZWL9_XENLA Psmc3‐b protein Xenopus laevis (African clawed frog) 423 100.00% ORF Names:GSPATT00020982001 EMBL CAK87340.1OrganismParamecium tetraurelia ARP58177_P050 Q7SZ30_XENLA Psmc3‐prov protein Xenopus laevis (African clawed frog) 423 100.00% ORF Names:GSPATT00020982001 EMBL CAK87340.1OrganismParamecium Proteasome (Prosome, macropain) 26S Xenopus tropicalis (Western clawed frog) tetraurelia ARP58177_P050 Q6DIE6_XENTR subunit, ATPase, 3 (Silurana tropicalis) 423 100.00%

ORF Names:GSPATT00020982001 26S protease regulatory subunit 6A‐A (26S EMBL proteasome AAA‐ATPase subunit RPT5‐A) CAK87340.1OrganismParamecium (Proteasome 26S subunit ATPase 3‐A) (Tat‐ tetraurelia ARP58177_P050 PR6AA_XENLA binding protein 6) (TBP‐6) Xenopus laevis (African clawed frog) 405 100.00%

ORF Names:GSPATT00020982001 26S protease regulatory subunit 6A‐B (26S EMBL proteasome AAA‐ATPase subunit RPT5‐B) CAK87340.1OrganismParamecium (Proteasome 26S subunit ATPase 3‐B) (Tat‐ tetraurelia ARP58177_P050 PR6AB_XENLA binding protein 10) (TBP‐10) Xenopus laevis (African clawed frog) 404 92.00% Hairy/enhancer‐of‐split related with YRPW Xenopus tropicalis (Western clawed frog) ARP38979_P050 HEY1_XENTR motif protein 1 (Silurana tropicalis) 300 90.00%

Hairy/enhancer‐of‐split related with YRPW motif protein 1 (XHey‐1) (Hairy and enhancer of split‐related protein 1) (Hesr‐1) (Hairy‐ related transcription factor 1) (HRT‐1) (XHRT1) hey2 ARP38979_P050 HEY1_XENLA (xHRT‐1) (Protein xbc8) Xenopus laevis (African clawed frog) 294 90.00%

Ordered Locus Names:HTH_1317ORF Names:Hydth_1309 EMBL ADO45696.1OrganismHydrogenobacter thermophilus (strain DSM 6534 / IAM 12695 / TK‐6) ARP40797_P050 Q6DDU3_XENLA Exosc7‐prov protein Xenopus laevis (African clawed frog) 291 85.00% Ordered Locus Names:HTH_1317ORF Names:Hydth_1309 EMBL ADO45696.1OrganismHydrogenobacter thermophilus (strain DSM 6534 / IAM Xenopus tropicalis (Western clawed frog) 12695 / TK‐6) ARP40797_P050 Q0IIZ7_XENTR Hypothetical LOC496941 (Silurana tropicalis) 291 85.00%

Ordered Locus Names:HTH_1317ORF Names:Hydth_1309 EMBL ADO45696.1OrganismHydrogenobacter thermophilus (strain DSM 6534 / IAM Xenopus tropicalis (Western clawed frog) 12695 / TK‐6) ARP40797_P050 Q5I0A3_XENTR LOC496941 protein (Fragment) (Silurana tropicalis) 289 78.00%

Ordered Locus Names:HTH_1317ORF Names:Hydth_1309 EMBL ADO45696.1OrganismHydrogenobacter thermophilus (strain DSM 6534 / IAM Xenopus tropicalis (Western clawed frog) 12695 / TK‐6) ARP40797_P050 Q28JA6_XENTR Exosome component 7 (Silurana tropicalis) 291 78.00% Xenopus tropicalis (Western clawed frog) ARP54451_P050 Q6GL80_XENTR Hydroxymethylbilane synthase (Silurana tropicalis) 351 100.00% ARP54451_P050 Q3KQ72_XENLA MGC130905 protein Xenopus laevis (African clawed frog) 351 100.00% 45 kDa calcium‐binding protein (Cab45) Xenopus tropicalis (Western clawed frog) SDF4 ARP47222_T100 CAB45_XENTR (Stromal cell‐derived factor 4) (SDF‐4) (Silurana tropicalis) 360 85.00% 45 kDa calcium‐binding protein (Cab45) SDF4 ARP47222_T100 CAB45_XENLA (Stromal cell‐derived factor 4) (SDF‐4) Xenopus laevis (African clawed frog) 360 85.00% ARP38479_P050 A1A5K1_XENLA LOC100125667 protein Xenopus laevis (African clawed frog) 200 84.00%

Forkhead box protein A1‐B (FoxA1b) (Fork head domain‐related protein 7') (xFD‐7') (Forkhead protein 2) (FKH‐2) (xFKH2) (Hepatocyte nuclear factor 3‐alpha homolog foxa1 ARP38479_P050 FXA1B_XENLA B) (HNF3alpha homolog B) (xHNF3alpha‐B) Xenopus laevis (African clawed frog) 427 84.00%

Forkhead box protein A1‐A (FoxA1a) (Fork head domain‐related protein 7) (xFD‐7) (Hepatocyte nuclear factor 3‐alpha homolog foxa1 ARP38479_P050 FXA1A_XENLA A) (HNF3alpha homolog A) (xHNF3alpha‐A) Xenopus laevis (African clawed frog) 429 84.00% Xenopus tropicalis (Western clawed frog) foxa1 ARP38479_P050 FOXA1_XENTR Forkhead box protein A1 (FoxA1) (tFoxA1) (Silurana tropicalis) 428 84.00% Xenopus tropicalis (Western clawed frog) foxa1 ARP38479_P050 B7ZT57_XENTR Forkhead box A2 (Silurana tropicalis) 434 76.00% Forkhead box protein A2‐A (FoxA2‐A) (FoxA2a) (Fork head domain‐related protein 3) (xFD‐3) (Hepatocyte nuclear factor 3‐beta homolog A) (HNF‐3‐beta‐A) (HNF3‐beta homolog A) (HNF3‐beta‐A) (xHNF3‐beta‐A) foxa1 ARP38479_P050 FXA2A_XENLA (xbeta‐1) Xenopus laevis (African clawed frog) 434 76.00% Xenopus tropicalis (Western clawed frog) foxa1 ARP38479_P050 FOXA2_XENTR Forkhead box protein A2 (FoxA2) (Silurana tropicalis) 434 76.00%

Forkhead box protein A2‐B (FoxA2‐B) (FoxA2b) (Fork head domain‐related protein 3') (xFD‐3') (Hepatocyte nuclear factor 3‐beta homolog B) (HNF‐3‐beta‐B) (HNF3‐beta foxa1 ARP38479_P050 FXA2B_XENLA homolog B) (HNF3‐beta‐B) (xHNF3‐beta‐B) Xenopus laevis (African clawed frog) 433 76.00% Cdc2‐prov protein (Cell division cycle 2, G1 to Xenopus tropicalis (Western clawed frog) mink1 AVARP01020_P050 Q6P7L3_XENTR S and G2 to M) (Silurana tropicalis) 302 100.00% Xenopus tropicalis (Western clawed frog) mink1 AVARP01020_P050 Q28FA6_XENTR Cell division cycle 2, G1 to S and G2 to M (Silurana tropicalis) 302 100.00%

Cyclin‐dependent kinase 1‐B (CDK1‐B) (EC 2.7.11.22) (EC 2.7.11.23) (Cell division control protein 2 homolog 2) (Cell division control protein 2‐B) (Cell division protein kinase 1) mink1 AVARP01020_P050 CDK1B_XENLA (p34 protein kinase 2) Xenopus laevis (African clawed frog) 302 100.00%

Cyclin‐dependent kinase 1‐A (CDK1‐A) (EC 2.7.11.22) (EC 2.7.11.23) (Cell division control protein 2 homolog 1) (Cell division control protein 2‐A) (Cell division protein kinase 1‐A) mink1 AVARP01020_P050 CDK1A_XENLA (p34 protein kinase 1) Xenopus laevis (African clawed frog) 302 100.00% mink1 AVARP01020_P050 Q6GP94_XENLA LOC443633 protein (Fragment) Xenopus laevis (African clawed frog) 315 90.00% Mink protein (Misshapen/Nck interacting mink1 AVARP01020_P050 Q6DDZ8_XENLA Kinase) Xenopus laevis (African clawed frog) 1270 90.00% mink1 AVARP01020_P050 Q32NV8_XENLA LOC443633 protein Xenopus laevis (African clawed frog) 485 90.00% Xenopus tropicalis (Western clawed frog) mink1 AVARP01020_P050 A0JM35_XENTR Putative uncharacterized protein MGC146127 (Silurana tropicalis) 1188 90.00% ANO10 ARP47389_P050 Q6NUA4_XENLA LOC414707 protein (Fragment) Xenopus laevis (African clawed frog) 624 100.00% ARP34418_T100 Q6P6Z3_XENLA MGC68617 protein Xenopus laevis (African clawed frog) 241 85.00% Xenopus tropicalis (Western clawed frog) ARP34418_T100 Q6GL03_XENTR Ariadne homolog 2 (Silurana tropicalis) 491 85.00% ARP34418_T100 Q68F65_XENLA Arih2 protein Xenopus laevis (African clawed frog) 492 85.00% ORF Names:v1g168894OrganismNematostel F‐box leucine‐rich repeat protein 13 la vectensis (Starlet sea anemone) ARP52968_P050 Q9PTL7_XENLA (Fragment) Xenopus laevis (African clawed frog) 374 92.00%

ORF Names:v1g168894OrganismNematostel la vectensis (Starlet sea anemone) ARP52968_P050 Q6AZS0_XENLA Fbl13 protein Xenopus laevis (African clawed frog) 400 92.00% SEPSECS ARP41159_P050 A5PKQ6_XENLA LOC100101304 protein Xenopus laevis (African clawed frog) 506 100.00%

O‐phosphoseryl‐tRNA(Sec) selenium transferase (EC 2.9.1.2) (Selenocysteine synthase) (Sec synthase) (Selenocysteinyl‐ tRNA(Sec) synthase) (Sep‐tRNA:Sec‐tRNA synthase) (SepSecS) (UGA suppressor tRNA‐ Xenopus tropicalis (Western clawed frog) SEPSECS ARP41159_P050 SPCS_XENTR associated protein) (Silurana tropicalis) 506 100.00% ORF Names:NB231_08988 EMBL EAR22574.1OrganismNitrococcus mobilis Nb‐231 ARP46721_P050 Q6IRQ6_XENLA MGC81520 protein Xenopus laevis (African clawed frog) 472 92.00% ORF Names:NB231_08988 EMBL EAR22574.1OrganismNitrococcus Xenopus tropicalis (Western clawed frog) mobilis Nb‐231 ARP46721_P050 Q0VGY2_XENTR Putative uncharacterized protein MGC79656 (Silurana tropicalis) 472 92.00% ARP40176_P050 Q7ZY52_XENLA Gapd‐prov protein Xenopus laevis (African clawed frog) 333 78.00%

Glyceraldehyde‐3‐phosphate dehydrogenase (GAPDH) (EC 1.2.1.12) (Peptidyl‐cysteine S‐ ARP40176_P050 G3P_XENLA nitrosylase GAPDH) (EC 2.6.99.‐) Xenopus laevis (African clawed frog) 333 78.00%

Glyceraldehyde‐3‐phosphate dehydrogenase ARP40176_P050 Q8AY70_XENLA type B (Mg:bb02e05‐prov protein) Xenopus laevis (African clawed frog) 333 78.00% Xenopus tropicalis (Western clawed frog) ARP40176_P050 Q6DIU7_XENTR Glyceraldehyde‐3‐phosphate dehydrogenase (Silurana tropicalis) 293 90.00% Xenopus tropicalis (Western clawed frog) ARP40176_P050 Q28HJ8_XENTR Glyceraldehyde 3 phosphate dehydrogenase (Silurana tropicalis) 334 90.00%

ORF Names:v1g170236OrganismNematostel CHRAC17 protein (DNA polymerase epsilon la vectensis (Starlet sea anemone) ARP33054_T100 Q6WSQ3_XENLA p17 subunit) (Histone‐fold protein CHRAC17) Xenopus laevis (African clawed frog) 147 100.00%

ORF Names:v1g170236OrganismNematostel Polymerase (DNA directed), epsilon 3 (P17 Xenopus tropicalis (Western clawed frog) la vectensis (Starlet sea anemone) ARP33054_T100 Q28J93_XENTR subunit) (Silurana tropicalis) 147 100.00% Xenopus tropicalis (Western clawed frog) Fubp3 ARP51746_P050 A4IH51_XENTR Fubp3 protein (Silurana tropicalis) 546 92.00% Fubp3 ARP51746_P050 Q6PAA0_XENLA MGC68532 protein Xenopus laevis (African clawed frog) 546 85.00% Xenopus tropicalis (Western clawed frog) ARP39499_P050 Q6DIE9_XENTR Ovo‐like 2 (Ovo‐like 2 (Drosophila)) (Silurana tropicalis) 287 80.00%

ORF Names:IscW_ISCW010935 EMBL EEC14560.1OrganismIxodes scapularis (Black‐legged tick) (Deer tick) ARP33000_T100 LDB2_XENLA Isoform a Xenopus laevis (African clawed frog) 373 100.00%

ORF Names:IscW_ISCW010935 EMBL EEC14560.1OrganismIxodes scapularis (Black‐legged tick) (Deer tick) ARP33000_T100 LDB2_XENLA LIM domain‐binding protein 2 (LDB‐2) (xLdb2) Xenopus laevis (African clawed frog) 398 100.00% SMAD1 ARP38692_T100 Q98TU1_XENLA Smad protein Xenopus laevis (African clawed frog) 466 100.00% SMAD1 ARP38692_T100 Q91913_XENLA Mad1 protein Xenopus laevis (African clawed frog) 464 100.00% SMAD1 ARP38692_T100 Q8QGG6_XENLA Smad8A Xenopus laevis (African clawed frog) 466 100.00% SMAD1 ARP38692_T100 Q8QGG5_XENLA Smad8B Xenopus laevis (African clawed frog) 468 100.00% SMAD1 ARP38692_T100 Q8QGG4_XENLA Smad8C Xenopus laevis (African clawed frog) 466 100.00% SMAD1 ARP38692_T100 Q6PF37_XENLA MGC69016 protein Xenopus laevis (African clawed frog) 465 100.00% SMAD1 ARP38692_T100 Q6PF32_XENLA Xmad protein Xenopus laevis (African clawed frog) 464 100.00% Xenopus tropicalis (Western clawed frog) SMAD1 ARP38692_T100 Q6DIZ6_XENTR SMAD family member 9 (Silurana tropicalis) 466 100.00% Xenopus tropicalis (Western clawed frog) SMAD1 ARP38692_T100 Q6DIS7_XENTR SMAD family member 1 (Silurana tropicalis) 464 100.00% SMAD1 ARP38692_T100 Q5HZ76_XENLA MADH1 protein Xenopus laevis (African clawed frog) 464 100.00% SMAD1 ARP38692_T100 P79947_XENLA Smad1.1 Xenopus laevis (African clawed frog) 467 100.00% SMAD1 ARP38692_T100 Q91693_XENLA Mothers against DPP Xenopus laevis (African clawed frog) 464 100.00% pias2 ARP39231_P050 Q8JGN6_XENLA Protein inhibitor of activated STAT1 Xenopus laevis (African clawed frog) 649 100.00% pias2 ARP39231_P050 Q5XHH3_XENLA Pias1‐A protein Xenopus laevis (African clawed frog) 649 100.00% Xenopus tropicalis (Western clawed frog) pias2 ARP39231_P050 B0JZD8_XENTR Pias3 protein (Silurana tropicalis) 635 85.00% pias2 ARP39231_P050 Q6IRN4_XENLA MGC83751 protein Xenopus laevis (African clawed frog) 584 78.00% Xenopus tropicalis (Western clawed frog) pias2 ARP39231_P050 Q0P4Y0_XENTR Protein inhibitor of activated STAT, 2 (Silurana tropicalis) 620 78.00% pias2 ARP39231_P050 Q6GMA8_XENLA MGC81944 protein Xenopus laevis (African clawed frog) 633 78.00% TSPAN5 ARP46640_P050 Q7ZYS9_XENLA Tm4sf9 protein Xenopus laevis (African clawed frog) 268 84.00% TSPAN5 ARP46640_P050 Q5BIY7_XENLA Tm4sf9 protein Xenopus laevis (African clawed frog) 219 84.00% Xenopus tropicalis (Western clawed frog) TSPAN5 ARP46640_P050 Q0VFQ2_XENTR Tetraspanin 5 (Silurana tropicalis) 268 84.00% TSPAN5 ARP46640_P050 Q501Q6_XENLA MGC99260 protein Xenopus laevis (African clawed frog) 268 84.00% POPDC2 ARP41627_P050 Q640L0_XENLA LOC494649 protein Xenopus laevis (African clawed frog) 351 78.00% Xenopus tropicalis (Western clawed frog) POPDC2 ARP41627_P050 B1H1F6_XENTR Popeye domain containing 3 (Silurana tropicalis) 289 75.00% PCCA ARP33071_P050 Q5EAT1_XENLA Pcca protein Xenopus laevis (African clawed frog) 710 91.00% Thyrotropin‐releasing hormone receptor 1 trhr2‐A AVARP13104_T100 Q8JFZ5_XENLA (Fragment) Xenopus laevis (African clawed frog) 397 78.00% trhr2‐A AVARP13104_T100 Q8JFZ6_XENLA Thyrotropin‐releasing hormone receptor 2 Xenopus laevis (African clawed frog) 401 78.00% trhr2‐A AVARP13104_T100 B7ZQE5_XENLA Thyrotropin‐releasing hormone receptor 2 Xenopus laevis (African clawed frog) 401 78.00% ARP38224_P050 Q8QG95_XENLA Baf57 Xenopus laevis (African clawed frog) 423 100.00% ARP38224_P050 Q8AVX7_XENLA Smarce1 protein Xenopus laevis (African clawed frog) 402 100.00% SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily Xenopus tropicalis (Western clawed frog) ARP38224_P050 Q6GLG1_XENTR e, member 1 (Silurana tropicalis) 435 100.00% ARP38224_P050 Q5XH26_XENLA Smarce1 protein Xenopus laevis (African clawed frog) 423 100.00%

Ordered Locus Names:Pcal_0113OrganismPyrobaculu Xenopus tropicalis (Western clawed frog) m calidifontis (strain JCM 11548 / VA1) ARP46105_P050 A4QN94_XENTR LOC100125119 protein (Fragment) (Silurana tropicalis) 2232 92.00%

ORF Names:wu:fb78c02 ZFIN ZDB‐ GENE‐030131‐1699OrganismDanio rerio (Zebrafish) (Brachydanio rerio) ARP35504_T100 Q9YH11_XENLA Putative ClC‐3 Xenopus laevis (African clawed frog) 791 100.00%

ORF Names:wu:fb78c02 ZFIN ZDB‐ GENE‐030131‐1699OrganismDanio Xenopus tropicalis (Western clawed frog) rerio (Zebrafish) (Brachydanio rerio) ARP35504_T100 B4F6X6_XENTR Putative uncharacterized protein (Silurana tropicalis) 818 100.00%

ORF Names:wu:fb78c02 ZFIN ZDB‐ GENE‐030131‐1699OrganismDanio rerio (Zebrafish) (Brachydanio rerio) ARP35504_T100 A5PKR3_XENLA Chloride channel ClC‐3‐like Xenopus laevis (African clawed frog) 791 100.00%

ORF Names:wu:fb78c02 ZFIN ZDB‐ GENE‐030131‐1699OrganismDanio rerio (Zebrafish) (Brachydanio rerio) ARP35504_T100 Q9PWK7_XENLA Chloride channel 5 (Chloride channel ClC‐5) Xenopus laevis (African clawed frog) 808 90.00%

ORF Names:wu:fb78c02 ZFIN ZDB‐ GENE‐030131‐1699OrganismDanio Chloride channel 5 (Nephrolithiasis 2, X‐ Xenopus tropicalis (Western clawed frog) rerio (Zebrafish) (Brachydanio rerio) ARP35504_T100 Q28C29_XENTR linked, Dent disease) (Silurana tropicalis) 808 90.00%

ORF Names:wu:fb78c02 ZFIN ZDB‐ GENE‐030131‐1699OrganismDanio rerio (Zebrafish) (Brachydanio rerio) ARP35504_T100 A2BD91_XENLA Clcn5‐A protein (Fragment) Xenopus laevis (African clawed frog) 764 90.00% ORF Names:wu:fb78c02 ZFIN ZDB‐ GENE‐030131‐1699OrganismDanio Xenopus tropicalis (Western clawed frog) rerio (Zebrafish) (Brachydanio rerio) ARP35504_T100 B0BMM3_XENTR LOC100145074 protein (Silurana tropicalis) 760 81.00% FTZ‐F1‐related nuclear orphan receptor NR5A2 ARP32524_P050 Q91601_XENLA variant Xenopus laevis (African clawed frog) 333 92.00% NR5A2 ARP32524_P050 Q91544_XENLA Ftz‐F1‐related orphan receptor A Xenopus laevis (African clawed frog) 501 92.00% FTZ‐F1‐related nuclear orphan receptor NR5A2 ARP32524_P050 B7ZQD9_XENLA variant Xenopus laevis (African clawed frog) 501 92.00% NR5A2 ARP32524_P050 B7ZQD7_XENLA Xff1rashort protein Xenopus laevis (African clawed frog) 501 92.00%

NR5A2 ARP32524_P050 Q91545_XENLA Ftz‐F1‐related orphan receptor B (Fragment) Xenopus laevis (African clawed frog) 468 92.00% Nuclear receptor subfamily 5, group A, Xenopus tropicalis (Western clawed frog) NR5A2 ARP32524_P050 Q5XGE7_XENTR member 2 (Silurana tropicalis) 501 92.00% ORF Names:PANDA_007456 EMBL EFB24765.1OrganismAiluropoda melanoleuca (Giant panda) ARP39599_T100 Q6DDW0_XENLA MGC81685 protein Xenopus laevis (African clawed frog) 361 92.00% ORF Names:PANDA_007456 EMBL EFB24765.1OrganismAiluropoda melanoleuca (Giant panda) ARP39599_T100 Q6DD14_XENLA MGC80451 protein Xenopus laevis (African clawed frog) 405 92.00%

ORF Names:v1g121407OrganismNematostel Xenopus tropicalis (Western clawed frog) la vectensis (Starlet sea anemone) ARP47675_P050 B3DL09_XENTR LOC100170444 protein (Silurana tropicalis) 549 92.00%

ORF Putative methyltransferase METT10D (EC Names:v1g121407OrganismNematostel 2.1.1.‐) (Methyltransferase 10 domain‐ la vectensis (Starlet sea anemone) ARP47675_P050 MET10_XENLA containing protein) Xenopus laevis (African clawed frog) 547 92.00% ZBTB12 ARP40042_P050 Q6IP05_XENLA MGC79103 protein Xenopus laevis (African clawed frog) 460 92.00% Mfn2 ARP42419_P050 Q6NRV9_XENLA MGC81251 protein Xenopus laevis (African clawed frog) 756 76.00% Xenopus tropicalis (Western clawed frog) Mfn2 ARP42419_P050 Q28CS2_XENTR Mitofusin 2 (Silurana tropicalis) 756 76.00% Xenopus tropicalis (Western clawed frog) Mfn2 ARP42419_P050 B7ZTV0_XENTR Mitofusin 2 (Silurana tropicalis) 756 76.00%

ORF Names:DKEY‐23G12.2‐001 EMBL CAM15630.1, zgc:153725 ZFIN ZDB‐ GENE‐060929‐80OrganismDanio rerio (Zebrafish) (Brachydanio rerio) ARP56343_P050 Q5U5B2_XENLA LOC495312 protein Xenopus laevis (African clawed frog) 729 100.00% ORF Names:DKEY‐23G12.2‐001 EMBL CAM15630.1, zgc:153725 ZFIN ZDB‐ GENE‐060929‐80OrganismDanio rerio (Zebrafish) (Brachydanio rerio) ARP56343_P050 Q804T2_XENLA Ser/Thr protein kinase PAR‐1A Xenopus laevis (African clawed frog) 725 92.00%

ORF Names:DKEY‐23G12.2‐001 EMBL CAM15630.1, zgc:153725 ZFIN ZDB‐ GENE‐060929‐80OrganismDanio rerio (Zebrafish) (Brachydanio rerio) ARP56343_P050 Q6PA64_XENLA MARK3 protein Xenopus laevis (African clawed frog) 594 92.00% ARP48436_T100 Q6DJI2_XENLA MGC83413 protein Xenopus laevis (African clawed frog) 168 78.00% ARP48436_T100 Q66KZ0_XENLA MGC85304 protein Xenopus laevis (African clawed frog) 204 76.00% ARP44317_P050 Q91402_9PIPI Hepatocyte growth factor Xenopus 710 83.00% Ecto‐nucleosidase triphosphate entpd7 ARP49493_P050 Q2QDE0_XENLA diphosphohydrolase 7 (Fragment) Xenopus laevis (African clawed frog) 602 83.00% Ectonucleoside triphosphate Xenopus tropicalis (Western clawed frog) entpd7 ARP49493_P050 B7ZSS2_XENTR diphosphohydrolase 7 (Silurana tropicalis) 610 75.00%

Ectonucleoside triphosphate Xenopus tropicalis (Western clawed frog) entpd7 ARP49493_P050 ENTP7_XENTR diphosphohydrolase 7 (NTPDase 7) (EC 3.6.1.‐) (Silurana tropicalis) 610 75.00% Calcitonin gene‐related peptide type 1 receptor (CGRP type 1 receptor) (Calcitonin Xenopus tropicalis (Western clawed frog) Calcrl ARP42260_P050 CALRL_XENTR receptor‐like receptor) (Silurana tropicalis) 472 92.00% Calcitonin gene‐related peptide type 1 receptor (CGRP type 1 receptor) (Calcitonin Calcrl ARP42260_P050 CALRL_XENLA receptor‐like receptor) Xenopus laevis (African clawed frog) 476 92.00% 9‐Sep ARP51755_P050 Q498G4_XENLA MGC115227 protein Xenopus laevis (African clawed frog) 336 92.00% Xenopus tropicalis (Western clawed frog) 9‐Sep ARP51755_P050 Q28CX7_XENTR Novel protein similar to 9 (Fragment) (Silurana tropicalis) 417 92.00% 9‐Sep ARP51755_P050 Q6PF46_XENLA MGC68931 protein Xenopus laevis (African clawed frog) 327 75.00% Xenopus tropicalis (Western clawed frog) 9‐Sep ARP51755_P050 Q5BL76_XENTR Sept3 protein (Silurana tropicalis) 324 75.00% ORF Names:GSPATT00022750001 EMBL CAK89578.1OrganismParamecium tetraurelia ARP53358_P050 Q498E5_XENLA Chc1‐b‐prov protein Xenopus laevis (African clawed frog) 325 78.00% Xenopus tropicalis (Western clawed frog) Akt1 ARP30321_P050 B1WB72_XENTR Akt2 protein (Silurana tropicalis) 485 100.00% RAC‐beta serine/threonine‐protein kinase A (EC 2.7.11.1) (Protein kinase Akt‐2‐A) (Protein kinase B, beta‐A) (PKB beta‐A) (RAC‐PK‐beta‐ Akt1 ARP30321_P050 AKT2A_XENLA A) Xenopus laevis (African clawed frog) 486 100.00% RAC‐alpha serine/threonine‐protein kinase (EC 2.7.11.1) (Protein kinase Akt‐1) (xAkt) (Protein kinase B, alpha) (PKB alpha) (RAC‐PK‐ Akt1 ARP30321_P050 AKT1_XENLA alpha) Xenopus laevis (African clawed frog) 481 100.00% RAC‐beta serine/threonine‐protein kinase B (EC 2.7.11.1) (Protein kinase Akt‐2‐B) (Protein kinase B, beta‐B) (PKB beta‐B) (RAC‐PK‐beta‐ Akt1 ARP30321_P050 AKT2B_XENLA B) Xenopus laevis (African clawed frog) 485 90.00% Nmt2 ARP46299_P050 Q7ZYT2_XENLA Nmt1‐prov protein Xenopus laevis (African clawed frog) 484 92.00% Xenopus tropicalis (Western clawed frog) Nmt2 ARP46299_P050 Q0IJ16_XENTR Putative uncharacterized protein MGC145283 (Silurana tropicalis) 498 92.00% Nmt2 ARP46299_P050 Q6DKD8_XENLA MGC83363 protein Xenopus laevis (African clawed frog) 498 85.00% ORF Names:ACLA_020510 EMBL EAW07344.1OrganismAspergillus Acyl‐Coenzyme A dehydrogenase, Xenopus tropicalis (Western clawed frog) clavatus ARP54586_P050 Q6DJ59_XENTR short/branched chain (Silurana tropicalis) 361 92.00% ORF Names:ACLA_020510 EMBL EAW07344.1OrganismAspergillus Acyl‐Coenzyme A dehydrogenase, Xenopus tropicalis (Western clawed frog) clavatus ARP54586_P050 Q28FB8_XENTR short/branched chain (Silurana tropicalis) 429 92.00% ORF Names:ACLA_020510 EMBL EAW07344.1OrganismAspergillus clavatus ARP54586_P050 Q640G3_XENLA LOC494679 protein (Fragment) Xenopus laevis (African clawed frog) 438 85.00% SPTLC2 ARP48652_P050 Q6GP36_XENLA MGC80715 protein Xenopus laevis (African clawed frog) 555 90.00% Xenopus tropicalis (Western clawed frog) ARP58726_P050 Q5XGB7_XENTR Hypothetical LOC496539 (Silurana tropicalis) 407 90.00% Thioredoxin domain containing 4 Xenopus tropicalis (Western clawed frog) ARP58726_P050 Q28HX8_XENTR (Endoplasmic reticulum) (Silurana tropicalis) 409 90.00% Xenopus tropicalis (Western clawed frog) ARP39103_T100 Q6P4Y7_XENTR Orthodenticle homeobox 1 (Silurana tropicalis) 336 78.00% ANKH ARP50237_P050 Q6NS07_XENLA Ank protein Xenopus laevis (African clawed frog) 492 85.00%

ANKH ARP50237_P050 ANKH_XENLA Progressive ankylosis protein homolog (ANK) Xenopus laevis (African clawed frog) 492 85.00%

ORF Names:v1g222801OrganismNematostel la vectensis (Starlet sea anemone) ARP52382_P050 Q5XGV4_XENLA Ect2 protein Xenopus laevis (African clawed frog) 986 92.00%

ORF Names:v1g222801OrganismNematostel Xenopus tropicalis (Western clawed frog) la vectensis (Starlet sea anemone) ARP52382_P050 A9JTS6_XENTR LOC100127840 protein (Silurana tropicalis) 878 92.00%

ORF Names:v1g222801OrganismNematostel la vectensis (Starlet sea anemone) ARP52382_P050 Q6RWT0_XENLA Epithelial cell transforming 2 Xenopus laevis (African clawed frog) 910 92.00% ORF Names:v1g222801OrganismNematostel la vectensis (Starlet sea anemone) ARP52382_P050 Q6GN25_XENLA ECT2 protein Xenopus laevis (African clawed frog) 985 92.00% Xenopus tropicalis (Western clawed frog) ARP53565_P050 Q6DF20_XENTR G protein‐coupled receptor kinase 4 (Silurana tropicalis) 575 92.00% ARP53565_P050 Q6DCW4_XENLA Gprk4‐A‐prov protein Xenopus laevis (African clawed frog) 575 92.00% ARP53565_P050 Q5XH04_XENLA Gprk4‐B‐prov protein Xenopus laevis (African clawed frog) 575 92.00% Xenopus tropicalis (Western clawed frog) ARP53565_P050 Q28DL5_XENTR G protein‐coupled receptor kinase 5 (Silurana tropicalis) 594 78.00% ORF Names:GSPATT00005000001 EMBL CAK58627.1OrganismParamecium Xenopus tropicalis (Western clawed frog) tetraurelia ARP48725_P050 A4IHM8_XENTR Polr3a protein (Silurana tropicalis) 1390 78.00%

ORF Names:IscW_ISCW012562 EMBL EEC16342.1OrganismIxodes scapularis Xenopus tropicalis (Western clawed frog) (Black‐legged tick) (Deer tick) ARP45209_P050 Q5BKK2_XENTR Fmo3 protein (Silurana tropicalis) 531 76.00%

ORF Names:IscW_ISCW012562 EMBL EEC16342.1OrganismIxodes scapularis Xenopus tropicalis (Western clawed frog) (Black‐legged tick) (Deer tick) ARP45209_P050 Q6DF15_XENTR MGC89174 protein (Silurana tropicalis) 534 83.00%

ORF Names:v1g237413OrganismNematostel Xenopus tropicalis (Western clawed frog) la vectensis (Starlet sea anemone) ARP56237_P050 Q5RJT9_XENTR Fas apoptotic inhibitory molecule (Silurana tropicalis) 179 100.00%

ORF Names:v1g237413OrganismNematostel la vectensis (Starlet sea anemone) ARP56237_P050 Q4V7P0_XENLA MGC115509 protein Xenopus laevis (African clawed frog) 179 100.00%

ORF Names:v1g237413OrganismNematostel Xenopus tropicalis (Western clawed frog) la vectensis (Starlet sea anemone) ARP56237_P050 B0BMR9_XENTR Faim protein (Silurana tropicalis) 179 100.00% ORF Names:GSPATT00007469001 EMBL CAK70029.1OrganismParamecium tetraurelia ARP49070_P050 Q6INC0_XENLA MGC83541 protein Xenopus laevis (African clawed frog) 492 92.00% ORF Names:GSPATT00007469001 EMBL CAK70029.1OrganismParamecium NIMA (Never in gene a)‐related kinase Xenopus tropicalis (Western clawed frog) tetraurelia ARP49070_P050 Q6DJQ5_XENTR 3 (Silurana tropicalis) 494 92.00% ORF Names:GSPATT00007469001 EMBL CAK70029.1OrganismParamecium NIMA (Never in mitosis gene a)‐related kinase Xenopus tropicalis (Western clawed frog) tetraurelia ARP49070_P050 Q28D72_XENTR 3 (Fragment) (Silurana tropicalis) 393 92.00% LOC780759 ARP48540_P050 Q6PAD4_XENLA MGC68785 protein Xenopus laevis (African clawed frog) 627 85.00% Xenopus tropicalis (Western clawed frog) LOC780759 ARP48540_P050 Q5EAL2_XENTR MGC107778 protein (Silurana tropicalis) 627 85.00% LOC780759 ARP48540_P050 Q5XGZ4_XENLA LOC779025 protein (Fragment) Xenopus laevis (African clawed frog) 480 78.00% LOC780759 ARP48540_P050 Q566F6_XENLA LOC780759 protein (Fragment) Xenopus laevis (African clawed frog) 656 78.00% LOC780759 ARP48540_P050 A8WH37_XENLA LOC780759 protein (Fragment) Xenopus laevis (African clawed frog) 656 78.00% LOC780759 ARP48540_P050 A0JMR2_XENLA LOC780759 protein (Fragment) Xenopus laevis (African clawed frog) 655 78.00% Xenopus tropicalis (Western clawed frog) celf5 ARP31525_P050 Q28HL6_XENTR Trinucleotide repeat containing 4 (Silurana tropicalis) 313 92.00% Xenopus tropicalis (Western clawed frog) celf5 ARP31525_P050 A8KBC9_XENTR Tnrc4 protein (Silurana tropicalis) 462 92.00%

CUGBP Elav‐like family member 3‐B (CELF3‐B) (Bruno‐like protein 1‐B) (CUG‐BP‐ and ETR‐3‐ like factor 3‐B) (ELAV‐type RNA‐binding protein 1‐B) (ETR‐1‐B) (RNA‐binding protein BRUNOL‐1‐B) (Trinucleotide repeat‐containing celf5 ARP31525_P050 CEL3B_XENLA gene 4 protein B) Xenopus laevis (African clawed frog) 462 92.00%

CUGBP Elav‐like family member 3‐A (CELF‐3A) (Bruno‐like protein 1‐A) (CUG‐BP‐ and ETR‐3‐ like factor 3‐A) (ELAV‐type RNA‐binding protein 1‐A) (ETR‐1‐A) (RNA‐binding protein BRUNOL‐1‐A) (Trinucleotide repeat‐containing celf5 ARP31525_P050 CEL3A_XENLA gene 4 protein A) Xenopus laevis (African clawed frog) 462 92.00% celf5 ARP31525_P050 B5LEQ7_XENLA RNA binding protein Bruno‐like 5a Xenopus laevis (African clawed frog) 132 92.00% celf5 ARP31525_P050 B5LEQ6_XENLA RNA binding protein Bruno‐like 5 Xenopus laevis (African clawed frog) 484 92.00%

CUGBP Elav‐like family member 5 (CELF‐5) (Bruno‐like protein 5) (CUG‐BP‐ and ETR‐3‐like Xenopus tropicalis (Western clawed frog) celf5 ARP31525_P050 CELF5_XENTR factor 5) (RNA‐binding protein BRUNOL‐5) (Silurana tropicalis) 486 92.00% celf5 ARP31525_P050 B5LEQ5_XENLA RNA binding protein Bruno‐like 4 Xenopus laevis (African clawed frog) 471 76.00%

CUGBP Elav‐like family member 4 (CELF‐4) (Bruno‐like protein 4) (CUG‐BP‐ and ETR‐3‐like Xenopus tropicalis (Western clawed frog) celf5 ARP31525_P050 CELF4_XENTR factor 4) (RNA‐binding protein BRUNOL‐4) (Silurana tropicalis) 424 76.00% Xenopus tropicalis (Western clawed frog) PAQR4 ARP49901_P050 A9UMC5_XENTR LOC100135309 protein (Silurana tropicalis) 339 100.00% PAQR4 ARP49901_P050 Q6AX66_XENLA MGC84006 protein Xenopus laevis (African clawed frog) 341 100.00% PAQR4 ARP49901_P050 Q52L08_XENLA MGC115032 protein Xenopus laevis (African clawed frog) 341 100.00% Progestin and adipoQ receptor family member Xenopus tropicalis (Western clawed frog) PAQR4 ARP49901_P050 Q08CW7_XENTR VI (Silurana tropicalis) 345 85.00% PAQR4 ARP49901_P050 Q5XHE4_XENLA LOC495023 protein Xenopus laevis (African clawed frog) 272 83.00% si:ch211‐127m10.2 ARP39322_P050 Q6PA95_XENLA MGC68575 protein Xenopus laevis (African clawed frog) 727 85.00% Xenopus tropicalis (Western clawed frog) si:ch211‐127m10.2 ARP39322_P050 Q08D47_XENTR B‐cell CLL/lymphoma 11A (Zinc finger protein) (Silurana tropicalis) 797 85.00% Xenopus tropicalis (Western clawed frog) ARP39398_P050 A4IHN9_XENTR LOC100124875 protein (Silurana tropicalis) 594 90.00% FOXC1 ARP38036_P050 FXC1B_XENLA Forkhead box protein C1‐B Xenopus laevis (African clawed frog) 495 78.00%

Forkhead box protein C1‐A (FoxC1) (Fork head FOXC1 ARP38036_P050 FXC1A_XENLA domain‐related protein 11) (XFD‐11) Xenopus laevis (African clawed frog) 492 78.00% Xenopus tropicalis (Western clawed frog) FOXC1 ARP38036_P050 FOXC1_XENTR Forkhead box protein C1 (Silurana tropicalis) 495 78.00% Xenopus tropicalis (Western clawed frog) parvab ARP46017_P050 Q6GLA6_XENTR Parvin, beta (Silurana tropicalis) 365 92.00% parvab ARP46017_P050 Q4QQZ5_XENLA MGC115486 protein Xenopus laevis (African clawed frog) 365 92.00% Cpne3 ARP40503_P050 Q6INK1_XENLA MGC82415 protein Xenopus laevis (African clawed frog) 533 84.00% Cpne3 ARP40503_P050 Q6P7H2_XENLA MGC68823 protein Xenopus laevis (African clawed frog) 533 76.00% Xenopus tropicalis (Western clawed frog) Cpne3 ARP40503_P050 Q4VA76_XENTR Putative uncharacterized protein mgc108079 (Silurana tropicalis) 533 76.00% ARP46303_P050 Q640D3_XENLA LOC494700 protein Xenopus laevis (African clawed frog) 369 92.00% Xenopus tropicalis (Western clawed frog) psat1 ARP46303_P050 Q28I26_XENTR Phosphoserine aminotransferase (Silurana tropicalis) 369 92.00% Xenopus tropicalis (Western clawed frog) psat1 ARP46303_P050 A0JPC0_XENTR Phosphoserine aminotransferase 1 (Silurana tropicalis) 369 92.00%

ORF Names:zgc:158856 ZFIN ZDB‐GENE‐ 070112‐1722OrganismDanio rerio Xenopus tropicalis (Western clawed frog) (Zebrafish) (Brachydanio rerio) ARP40657_P050 Q6DK79_XENTR Stem‐loop binding protein (Silurana tropicalis) 254 92.00%

ORF Names:zgc:158856 ZFIN ZDB‐GENE‐ 070112‐1722OrganismDanio rerio Histone RNA hairpin‐binding protein (Histone (Zebrafish) (Brachydanio rerio) ARP40657_P050 SLBP1_XENLA stem‐loop‐binding protein 1) Xenopus laevis (African clawed frog) 254 92.00%

ORF Names:zgc:158856 ZFIN ZDB‐GENE‐ 070112‐1722OrganismDanio rerio (Zebrafish) (Brachydanio rerio) ARP40657_P050 Q6GNP3_XENLA MGC80972 protein Xenopus laevis (African clawed frog) 254 85.00%

ORF Names:zgc:158856 ZFIN ZDB‐GENE‐ 070112‐1722OrganismDanio rerio Oocyte‐specific histone mRNA stem‐loop (Zebrafish) (Brachydanio rerio) ARP40657_P050 B7ZQW3_XENLA binding protein Xenopus laevis (African clawed frog) 250 85.00% ORF Names:zgc:158856 ZFIN ZDB‐GENE‐ 070112‐1722OrganismDanio rerio Oocyte‐specific histone RNA stem‐loop‐ (Zebrafish) (Brachydanio rerio) ARP40657_P050 SLBP2_XENLA binding protein 2 Xenopus laevis (African clawed frog) 250 85.00% ORF Names:VITISV_035660 EMBL CAN68143.1OrganismVitis vinifera 60S ribosome subunit biogenesis protein NIP7 Xenopus tropicalis (Western clawed frog) (Grape) ARP40833_T100 NIP7_XENTR homolog (Silurana tropicalis) 180 78.00% ORF Names:VITISV_035660 EMBL CAN68143.1OrganismVitis vinifera 60S ribosome subunit biogenesis protein NIP7 (Grape) ARP40833_T100 NIP7_XENLA homolog Xenopus laevis (African clawed frog) 180 78.00% Xenopus tropicalis (Western clawed frog) foxo1a ARP32107_P050 FOXO1_XENTR (FoxO1) (FoxO1A) (Silurana tropicalis) 626 85.00% Forkhead box protein O1 (FoxO1) (xFoxO1) foxo1a ARP32107_P050 FOXO1_XENLA (FoxO1A) Xenopus laevis (African clawed frog) 631 78.00% ARP43608_T100 Q6GR23_XENLA MGC81304 protein Xenopus laevis (African clawed frog) 460 80.00% ARP43608_T100 Q2VPM3_XENLA XIRF‐6 protein Xenopus laevis (African clawed frog) 459 80.00% ARP43608_T100 O57578_XENLA XIRF‐6 protein Xenopus laevis (African clawed frog) 459 80.00% Novel protein similar to interferon regulatory Xenopus tropicalis (Western clawed frog) ARP43608_T100 Q28ET3_XENTR factor transcription factor (Silurana tropicalis) 460 80.00% Xenopus tropicalis (Western clawed frog) ARP43608_T100 B0JZ05_XENTR Interferon regulatory factor 6 (Silurana tropicalis) 460 80.00%

ORF Names:v1g119550OrganismNematostel Xenopus tropicalis (Western clawed frog) la vectensis (Starlet sea anemone) ARP39504_T100 Q0VFE6_XENTR PR domain containing 12 (Silurana tropicalis) 354 78.00%

ORF Names:v1g119550OrganismNematostel la vectensis (Starlet sea anemone) ARP39504_T100 Q7T0V8_XENLA MGC68944 protein Xenopus laevis (African clawed frog) 355 78.00% Xenopus tropicalis (Western clawed frog) Fam76a ARP53097_P050 FA76B_XENTR Protein FAM76B (Silurana tropicalis) 337 85.00% Fam76a ARP53097_P050 FA76B_XENLA Protein FAM76B Xenopus laevis (African clawed frog) 337 85.00% Irf8 P100842_P050 Q6DE53_XENLA Icsbp1‐prov protein Xenopus laevis (African clawed frog) 411 84.00% Xenopus tropicalis (Western clawed frog) Lonrf2 ARP43319_P050 Q28BW8_XENTR Ring finger protein 127 (Silurana tropicalis) 771 90.00% osbpl9 ARP45659_P050 Q5U4J3_XENLA LOC495487 protein (Fragment) Xenopus laevis (African clawed frog) 722 78.00% DLX5 ARP31607_P050 Q6GLJ3_XENLA Dlx5 protein Xenopus laevis (African clawed frog) 286 78.00% DLL3 (Distal‐less homeo box 5) (Distal‐less Xenopus tropicalis (Western clawed frog) DLX5 ARP31607_P050 Q6GLH9_XENTR homeobox 5) (Silurana tropicalis) 289 78.00% DLX5 ARP31607_P050 Q641B4_XENLA MGC83327 protein Xenopus laevis (African clawed frog) 156 78.00% DLX5 ARP31607_P050 DLL3_XENLA Homeobox protein DLL‐3 (XDLL‐3) Xenopus laevis (African clawed frog) 289 78.00% IRF6 ARP38738_P050 Q6DD26_XENLA Putative uncharacterized protein Xenopus laevis (African clawed frog) 460 92.00% IRF6 ARP38738_P050 Q6GR23_XENLA MGC81304 protein Xenopus laevis (African clawed frog) 460 84.00% IRF6 ARP38738_P050 Q2VPM3_XENLA XIRF‐6 protein Xenopus laevis (African clawed frog) 459 84.00% Novel protein similar to interferon regulatory Xenopus tropicalis (Western clawed frog) IRF6 ARP38738_P050 Q28ET3_XENTR factor transcription factor (Silurana tropicalis) 460 84.00% Novel protein similar to interferon regulatory Xenopus tropicalis (Western clawed frog) IRF6 ARP38738_P050 Q28ES2_XENTR factor transcription factor (Silurana tropicalis) 460 84.00% IRF6 ARP38738_P050 O57578_XENLA XIRF‐6 protein Xenopus laevis (African clawed frog) 459 84.00% Xenopus tropicalis (Western clawed frog) IRF6 ARP38738_P050 B0JZ05_XENTR Interferon regulatory factor 6 (Silurana tropicalis) 460 76.00% ogt.1 ARP49154_P050 Q641I4_XENLA Ogt‐prov protein Xenopus laevis (African clawed frog) 1063 100.00% UDP‐N‐acetylglucosamine‐‐peptide N‐ Xenopus tropicalis (Western clawed frog) ogt.1 ARP49154_P050 Q5BL53_XENTR acetylglucosaminyltransferase (Silurana tropicalis) 1035 100.00% O‐linked N‐acetylglucosamine (GlcNAc) transferase (UDP‐N‐ acetylglucosamine:polypeptide‐N‐ Xenopus tropicalis (Western clawed frog) ogt.1 ARP49154_P050 Q28EC3_XENTR acetylglucosaminyl transferase) (Silurana tropicalis) 190 100.00% O‐linked N‐acetylglucosamine (GlcNAc) transferase (UDP‐N‐ acetylglucosamine:polypeptide‐N‐ Xenopus tropicalis (Western clawed frog) ogt.1 ARP49154_P050 Q0IJ26_XENTR acetylglucosaminyl transferase) (Silurana tropicalis) 190 100.00% Xenopus tropicalis (Western clawed frog) Rnf166 ARP40026_P050 Q0VFJ0_XENTR Ring finger protein 166 (Silurana tropicalis) 241 100.00% Rnf166 ARP40026_P050 RN166_XENLA RING finger protein 166 Xenopus laevis (African clawed frog) 241 100.00% Xenopus tropicalis (Western clawed frog) Rnf166 ARP40026_P050 Q6IZ49_XENTR Ring finger protein 114 (ZFP313 protein) (Silurana tropicalis) 223 92.00% Rnf166 ARP40026_P050 Q66IR3_XENLA MGC85497 protein Xenopus laevis (African clawed frog) 126 92.00% Rnf166 ARP40026_P050 Q5M9A8_XENLA LOC496148 protein Xenopus laevis (African clawed frog) 227 92.00% Rnf166 ARP40026_P050 Q6J2U7_XENLA Zfp313 protein (Fragment) Xenopus laevis (African clawed frog) 226 91.00% TJAP1 ARP42926_P050 Q2TAS0_XENLA MGC130982 protein Xenopus laevis (African clawed frog) 590 92.00% PAOX ARP53829_P050 Q5U4L6_XENLA LOC495472 protein Xenopus laevis (African clawed frog) 500 85.00% LOC100124428 ARP40396_P050 NBP1B_XENLA Nuclear cap‐binding protein subunit 1‐B Xenopus laevis (African clawed frog) 791 100.00% LOC100124428 ARP40396_P050 NBP1A_XENLA Nuclear cap‐binding protein subunit 1‐A Xenopus laevis (African clawed frog) 791 92.00% Nuclear cap‐binding protein subunit 1 (80 kDa nuclear cap‐binding protein) (CBP80) (NCBP Xenopus tropicalis (Western clawed frog) LOC100124428 ARP40396_P050 NCBP1_XENTR 80 kDa subunit) (Silurana tropicalis) 791 85.00%

ORF Names:v1g244165OrganismNematostel General transcription factor II H, polypeptide Xenopus tropicalis (Western clawed frog) la vectensis (Starlet sea anemone) ARP38047_T100 Q5FV97_XENTR 4 (Gtf2h4 protein) (Transcription factor tfb2) (Silurana tropicalis) 455 100.00%

ORF Names:v1g244165OrganismNematostel la vectensis (Starlet sea anemone) ARP38047_T100 Q6INF9_XENLA MGC83106 protein Xenopus laevis (African clawed frog) 455 92.00% abp1 ARP41908_P050 Q6DCR9_XENLA Aoc2‐prov protein Xenopus laevis (African clawed frog) 759 76.00% Xenopus tropicalis (Western clawed frog) abp1 ARP41908_P050 Q5BKL7_XENTR Aoc2 protein (Silurana tropicalis) 759 76.00% abp1 ARP41908_P050 A5PKN0_XENLA Putative uncharacterized protein Xenopus laevis (African clawed frog) 759 76.00% ARP55479_P050 Q6NTW7_XENLA MGC81482 protein Xenopus laevis (African clawed frog) 591 84.00% Xenopus tropicalis (Western clawed frog) ARP55479_P050 Q6DEZ5_XENTR Epsin 1 (Silurana tropicalis) 579 84.00% Pycr1 ARP57750_P050 Q6INR2_XENLA MGC81282 protein Xenopus laevis (African clawed frog) 320 100.00% Pyrroline‐5‐carboxylate reductase family, Xenopus tropicalis (Western clawed frog) Pycr1 ARP57750_P050 Q28C85_XENTR member 2 (Silurana tropicalis) 320 100.00% Xenopus tropicalis (Western clawed frog) Pycr1 ARP57750_P050 A9UM99_XENTR LOC100135284 protein (Silurana tropicalis) 320 100.00% Nuclear receptor subfamily 1, group H, Xenopus tropicalis (Western clawed frog) Nr1h3 ARP38670_P050 Q0IHW4_XENTR member 2 (Silurana tropicalis) 441 100.00% Nr1h3 ARP38670_P050 Q6GMA2_XENLA MGC81974 protein Xenopus laevis (African clawed frog) 441 92.00% Novel protein similar to torsin (Torsin family 1, Xenopus tropicalis (Western clawed frog) TOR1A ARP47036_T100 Q28CP8_XENTR member A (Torsin A)) (Silurana tropicalis) 327 85.00% Xenopus tropicalis (Western clawed frog) TOR1A ARP47036_T100 Q28CA4_XENTR Novel protein similar to torsin (Silurana tropicalis) 341 78.00% Xenopus tropicalis (Western clawed frog) zfp36l2 ARP38524_P050 TISD_XENTR Zinc finger protein 36, C3H1 type‐like 2 (Silurana tropicalis) 333 84.00% Zinc finger protein 36, C3H1 type‐like 2‐B zfp36l2 ARP38524_P050 TISDB_XENLA (CCCH zinc finger protein 3‐B) (XC3H‐3b) Xenopus laevis (African clawed frog) 364 84.00% Zinc finger protein 36, C3H1 type‐like 2‐A zfp36l2 ARP38524_P050 TISDA_XENLA (CCCH zinc finger protein 3) (XC3H‐3) Xenopus laevis (African clawed frog) 363 84.00% ORF Names:GSPATT00012183001 EMBL CAK76631.1OrganismParamecium tetraurelia ARP48718_T100 Q640E3_XENLA LOC494694 protein Xenopus laevis (African clawed frog) 218 100.00% ORF Names:GSPATT00012183001 EMBL CAK76631.1OrganismParamecium Xenopus tropicalis (Western clawed frog) tetraurelia ARP48718_T100 Q28HH8_XENTR Stromal cell‐derived factor 2 (Silurana tropicalis) 218 100.00% ORF Names:GSPATT00012183001 EMBL CAK76631.1OrganismParamecium tetraurelia ARP48718_T100 Q6DD41_XENLA MGC80358 protein Xenopus laevis (African clawed frog) 218 92.00% ORF Names:GSPATT00012183001 EMBL CAK76631.1OrganismParamecium MGC79547 protein (Stromal cell‐derived Xenopus tropicalis (Western clawed frog) tetraurelia ARP48718_T100 Q66JH3_XENTR factor 2‐like 1) (Silurana tropicalis) 218 92.00% ORF Names:GSPATT00012183001 EMBL CAK76631.1OrganismParamecium tetraurelia ARP48718_T100 Q5PPW6_XENLA LOC496057 protein Xenopus laevis (African clawed frog) 218 92.00% ARP38162_P050 Q6GPW1_XENLA MGC82572 protein Xenopus laevis (African clawed frog) 357 100.00% Xenopus tropicalis (Western clawed frog) ARP38162_P050 Q4JF54_XENTR NeuroD1 (Neurod1 protein) (Silurana tropicalis) 361 100.00%

ARP38162_P050 NDF1_XENLA Neurogenic differentiation factor 1 (NeuroD1) Xenopus laevis (African clawed frog) 352 100.00% Xenopus tropicalis (Western clawed frog) SMYD5 ARP50528_P050 Q5M7Q8_XENTR Smyd5‐prov protein (Fragment) (Silurana tropicalis) 420 92.00% Xenopus tropicalis (Western clawed frog) SMYD5 ARP50528_P050 A9ULL8_XENTR Smyd5 protein (Silurana tropicalis) 421 92.00%

SMYD5 ARP50528_P050 SMYD5_XENLA SET and MYND domain‐containing protein 5 Xenopus laevis (African clawed frog) 421 92.00% thio ARP56538_P050 Q640H2_XENLA LOC494715 protein Xenopus laevis (African clawed frog) 536 85.00% Xenopus tropicalis (Western clawed frog) thio ARP56538_P050 Q5EBE0_XENTR MGC108409 protein (Silurana tropicalis) 536 85.00% Zinc finger protein (Adipocyte enhancer‐ binding protein 2 homolog) (AE‐binding AEBP2 ARP31545_P050 AEBP2_XENLA protein 2 homolog) Xenopus laevis (African clawed frog) 358 100.00% ORF Names:zgc:171795 EMBL AAI50399.1 ZFIN ZDB‐GENE‐070820‐ 18OrganismDanio rerio (Zebrafish) (Brachydanio rerio) ARP48658_P050 Q6GQI6_XENLA Polr2ka protein (Polr2kb protein) Xenopus laevis (African clawed frog) 58 92.00% ORF Names:zgc:171795 EMBL AAI50399.1 ZFIN ZDB‐GENE‐070820‐ 18OrganismDanio rerio (Zebrafish) Polymerase (RNA) II (DNA directed) Xenopus tropicalis (Western clawed frog) (Brachydanio rerio) ARP48658_P050 Q28CR4_XENTR polypeptide K, 7.0kDa (Silurana tropicalis) 58 92.00% Xenopus tropicalis (Western clawed frog) Epb4.1l1 ARP54569_P050 A8KBD9_XENTR LOC100127644 protein (Silurana tropicalis) 823 78.00% ARP54429_P050 Q0IH33_XENLA MGC154801 protein Xenopus laevis (African clawed frog) 152 76.00% ARP54429_P050 CB068_XENLA UPF0561 protein C2orf68 homolog Xenopus laevis (African clawed frog) 151 76.00% Xenopus tropicalis (Western clawed frog) ARP39465_T100 A9ULC1_XENTR Nr2f2 protein (Silurana tropicalis) 408 78.00% ARP39465_T100 Q7ZXI7_XENLA Nr2f2 protein Xenopus laevis (African clawed frog) 405 78.00% ARP39465_T100 Q9W745_XENLA COUP transcription factor 1 Xenopus laevis (African clawed frog) 411 78.00% ARP39465_T100 Q6DCH6_XENLA Nr2f2 protein Xenopus laevis (African clawed frog) 404 78.00% Xenopus tropicalis (Western clawed frog) ARP39465_T100 A4QNF4_XENTR Nr2f1 protein (Silurana tropicalis) 410 78.00% Xenopus tropicalis (Western clawed frog) ndrg1 ARP47974_T100 NDRG1_XENTR Protein NDRG1 (Silurana tropicalis) 395 83.00% ndrg1 ARP47974_T100 NDR1A_XENLA Protein NDRG1‐A (xNDRG1‐A) Xenopus laevis (African clawed frog) 396 83.00% ARP47471_P050 Q7ZXM9_XENLA Tgm2‐prov protein (Fragment) Xenopus laevis (African clawed frog) 692 76.00% ARP47471_P050 Q7SZT2_XENLA Tgm2‐prov protein Xenopus laevis (African clawed frog) 690 76.00% ARP47471_P050 Q6INH7_XENLA MGC82568 protein Xenopus laevis (African clawed frog) 691 76.00% Xenopus tropicalis (Western clawed frog) ARP47471_P050 B3DM72_XENTR LOC100170618 protein (Silurana tropicalis) 691 81.00% Xenopus tropicalis (Western clawed frog) ARP32185_P050 B0JZ91_XENTR LOC100145170 protein (Silurana tropicalis) 286 92.00% ARP32185_P050 Q640D1_XENLA LOC494724 protein Xenopus laevis (African clawed frog) 286 84.00%

ORF Names:v1g81756OrganismNematostell a vectensis (Starlet sea anemone) ARP45817_T100 Q66IT6_XENLA LOC446941 protein (Fragment) Xenopus laevis (African clawed frog) 261 75.00%

ORF Names:v1g81756OrganismNematostell a vectensis (Starlet sea anemone) ARP45817_T100 Q0P3R0_XENLA Putative uncharacterized protein Xenopus laevis (African clawed frog) 256 75.00% Xenopus tropicalis (Western clawed frog) has2 ARP46595_P050 B1WAU6_XENTR Has2 protein (Silurana tropicalis) 552 100.00% has2 ARP46595_P050 Q6W9J2_XENLA Hyaluronic acid synthase 3 Xenopus laevis (African clawed frog) 557 92.00% Hyaluronan synthase 2 (EC 2.4.1.212) (Hyaluronate synthase 2) (Hyaluronic acid has2 ARP46595_P050 HAS2_XENLA synthase 2) (HA synthase 2) (xHAS2) Xenopus laevis (African clawed frog) 551 92.00% Hyaluronan synthase‐related protein (Hyaluronan synthase‐related sequence) has2 ARP46595_P050 HASR_XENLA (xHAS‐rs) Xenopus laevis (African clawed frog) 583 75.00% Hyaluronan synthase 1 (EC 2.4.1.212) (Hyaluronate synthase 1) (Hyaluronic acid Xenopus tropicalis (Western clawed frog) has2 ARP46595_P050 HAS1_XENTR synthase 1) (HA synthase 1) (Silurana tropicalis) 590 81.00%

ORF Names:TRIADDRAFT_19600 EMBL EDV29111.1OrganismTrichoplax adhaerens (Trichoplax reptans) ARP35790_P050 Q5EAU6_XENLA MGC85139 protein Xenopus laevis (African clawed frog) 125 85.00% NAAA ARP44939_P050 Q66KI1_XENLA MGC81819 protein Xenopus laevis (African clawed frog) 350 76.00% E3 ubiquitin‐protein ligase NRDP1 (EC 6.3.2.‐) RNF41 ARP34694_P050 RNF41_XENLA (RING finger protein 41) Xenopus laevis (African clawed frog) 317 78.00% Ordered Locus Names:BMASAVP1_0665OrganismBurk holderia mallei (strain SAVP1) ARP47287_P050 Q5PQA1_XENLA LOC495935 protein Xenopus laevis (African clawed frog) 328 85.00% Ordered Locus Names:BMASAVP1_0665OrganismBurk Xenopus tropicalis (Western clawed frog) holderia mallei (strain SAVP1) ARP47287_P050 B7ZU81_XENTR LOC549927 protein (Silurana tropicalis) 328 85.00% Ordered Locus Names:BMASAVP1_0665OrganismBurk Xenopus tropicalis (Western clawed frog) holderia mallei (strain SAVP1) ARP47287_P050 Q28HT8_XENTR Membrane interacting protein of RGS16 (Silurana tropicalis) 310 91.00% WD repeat domain phosphoinositide‐ ORF Names:TRIADDRAFT_20120 EMBL interacting protein 3 (WIPI‐3) (WD repeat‐ EDV29392.1OrganismTrichoplax containing protein 45‐like) (WDR45‐like Xenopus tropicalis (Western clawed frog) adhaerens (Trichoplax reptans) ARP34827_P050 WIPI3_XENTR protein) (Silurana tropicalis) 344 100.00% WD repeat domain phosphoinositide‐ ORF Names:TRIADDRAFT_20120 EMBL interacting protein 3 (WIPI‐3) (WD repeat‐ EDV29392.1OrganismTrichoplax containing protein 45‐like) (WDR45‐like adhaerens (Trichoplax reptans) ARP34827_P050 WIPI3_XENLA protein) Xenopus laevis (African clawed frog) 344 100.00% PEX3 ARP46090_T100 Q6GPP4_XENLA MGC82731 protein Xenopus laevis (African clawed frog) 372 100.00% Xenopus tropicalis (Western clawed frog) PEX3 ARP46090_T100 Q28F64_XENTR Peroxisomal biogenesis factor 3 (Silurana tropicalis) 369 100.00% Xenopus tropicalis (Western clawed frog) PEX3 ARP46090_T100 B0BLU2_XENTR Putative uncharacterized protein (Silurana tropicalis) 186 100.00% Xenopus tropicalis (Western clawed frog) ARP56138_P050 RS3A_XENTR 40S ribosomal protein S3a (Silurana tropicalis) 264 100.00% ARP56138_P050 RS3AB_XENLA 40S ribosomal protein S3a‐B Xenopus laevis (African clawed frog) 264 100.00% ARP56138_P050 RS3AA_XENLA 40S ribosomal protein S3a‐A Xenopus laevis (African clawed frog) 264 100.00% Xenopus tropicalis (Western clawed frog) esrrg ARP31655_T100 A4IIT9_XENTR Esrrg protein (Silurana tropicalis) 435 100.00% ORF Names:OsI_38419 EMBL EAY83209.1OrganismOryza sativa ‐associated protein Xenopus tropicalis (Western clawed frog) subsp. indica (Rice) ARP52439_P050 VP26B_XENTR 26B (Vesicle protein sorting 26B) (Silurana tropicalis) 337 100.00% ORF Names:OsI_38419 EMBL EAY83209.1OrganismOryza sativa Vacuolar protein sorting‐associated protein subsp. indica (Rice) ARP52439_P050 V26BB_XENLA 26B‐B (Vesicle protein sorting 26B‐B) Xenopus laevis (African clawed frog) 337 92.00% ORF Names:OsI_38419 EMBL EAY83209.1OrganismOryza sativa Vacuolar protein sorting‐associated protein subsp. indica (Rice) ARP52439_P050 V26BA_XENLA 26B‐A (Vesicle protein sorting 26B‐A) Xenopus laevis (African clawed frog) 337 92.00% ORF Names:OsI_38419 EMBL EAY83209.1OrganismOryza sativa Vacuolar protein sorting‐associated protein Xenopus tropicalis (Western clawed frog) subsp. indica (Rice) ARP52439_P050 VP26A_XENTR 26A (Vesicle protein sorting 26A) (Silurana tropicalis) 326 78.00% ORF Names:OsI_38419 EMBL EAY83209.1OrganismOryza sativa Vacuolar protein sorting‐associated protein subsp. indica (Rice) ARP52439_P050 V26AB_XENLA 26A‐B (Vesicle protein sorting 26A‐B) Xenopus laevis (African clawed frog) 326 78.00% ORF Names:OsI_38419 EMBL EAY83209.1OrganismOryza sativa Vacuolar protein sorting‐associated protein subsp. indica (Rice) ARP52439_P050 V26AA_XENLA 26A‐A (Vesicle protein sorting 26A‐A) Xenopus laevis (African clawed frog) 326 78.00% ZBTB7C ARP32872_T100 Q9PVP8_XENLA Champignon Xenopus laevis (African clawed frog) 470 92.00% ZBTB7C ARP32872_T100 Q2VPN0_XENLA Zbtb7b protein Xenopus laevis (African clawed frog) 470 92.00% ORF Names:ACLA_025700 EMBL EAW07853.1OrganismAspergillus Xenopus tropicalis (Western clawed frog) clavatus ARP40745_T100 OLA1_XENTR Obg‐like ATPase 1 (EC 3.6.3.‐) (Silurana tropicalis) 396 92.00% ORF Names:ACLA_025700 EMBL EAW07853.1OrganismAspergillus clavatus ARP40745_T100 Q6DDP5_XENLA Ola1 protein Xenopus laevis (African clawed frog) 281 85.00% ORF Names:ACLA_025700 EMBL EAW07853.1OrganismAspergillus clavatus ARP40745_T100 OLA1_XENLA Obg‐like ATPase 1 (EC 3.6.3.‐) Xenopus laevis (African clawed frog) 396 85.00% Xenopus tropicalis (Western clawed frog) ARP40166_P050 INSI2_XENTR ‐induced gene 2 protein (INSIG‐2) (Silurana tropicalis) 218 100.00% ARP40166_P050 INSI2_XENLA Insulin‐induced gene 2 protein (INSIG‐2) Xenopus laevis (African clawed frog) 218 100.00% Xenopus tropicalis (Western clawed frog) ARP40166_P050 INSI1_XENTR Insulin‐induced gene 1 protein (INSIG‐1) (Silurana tropicalis) 251 92.00% ARP40166_P050 A1L3F8_XENLA LOC100036994 protein Xenopus laevis (African clawed frog) 248 85.00% ARP40166_P050 INSI1_XENLA Insulin‐induced gene 1 protein (INSIG‐1) Xenopus laevis (African clawed frog) 251 78.00% V‐rel reticuloendotheliosis viral oncogene Xenopus tropicalis (Western clawed frog) P100779_T100 Q6NVN7_XENTR homolog A (Silurana tropicalis) 533 100.00% P100779_T100 Q6NRN5_XENLA Rela‐a protein Xenopus laevis (African clawed frog) 526 100.00% Putative transcription factor p65 homolog P100779_T100 TF65_XENLA (XRel1) Xenopus laevis (African clawed frog) 527 100.00%

V‐rel reticuloendotheliosis viral oncogene homolog B, nuclear factor of kappa light P100779_T100 B7ZS26_XENLA polypeptide gene enhancer in B‐cells 3 (Avian) Xenopus laevis (African clawed frog) 497 100.00% P100779_T100 RELB_XENLA Transcription factor RelB homolog Xenopus laevis (African clawed frog) 497 100.00%

V‐rel reticuloendotheliosis viral oncogene P100779_T100 Q91833_XENLA homolog (Avian) (Xrel2 protein) Xenopus laevis (African clawed frog) 583 84.00%

Nuclear factor of kappa light polypeptide gene Xenopus tropicalis (Western clawed frog) P100779_T100 Q6DF61_XENTR enhancer in B‐cells 2 (P49/p100) (Silurana tropicalis) 946 92.00% P100779_T100 O73789_XENLA Rel‐related embryonic oncoprotein Xenopus laevis (African clawed frog) 557 84.00% P100779_T100 B7ZRS2_XENLA LOC397698 protein Xenopus laevis (African clawed frog) 959 92.00% P100779_T100 B7ZRJ3_XENLA Rel3 protein Xenopus laevis (African clawed frog) 558 84.00% Xenopus tropicalis (Western clawed frog) P100779_T100 A4IIW1_XENTR Rel protein (Silurana tropicalis) 567 84.00% Nuclear factor NF‐kappa‐B p100 subunit (DNA‐ binding factor KBF2) (Nuclear factor of kappa light polypeptide gene enhancer in B‐cells 2) [Cleaved into: Nuclear factor NF‐kappa‐B p52 P100779_T100 NFKB2_XENLA subunit] Xenopus laevis (African clawed frog) 958 92.00% P100779_T100 Q66IP9_XENLA MGC86262 protein Xenopus laevis (African clawed frog) 959 91.00% ORF Names:Hbor_19730 EMBL ADQ67539.1OrganismHalogeometricu m borinquense DSM 11551 ARP33947_P050 Q5U4W5_XENLA LOC495418 protein Xenopus laevis (African clawed frog) 783 78.00% ORF Names:Hbor_19730 EMBL ADQ67539.1OrganismHalogeometricu m borinquense DSM 11551 ARP33947_P050 Q52KX0_XENLA LOC495418 protein (Fragment) Xenopus laevis (African clawed frog) 442 78.00% ORF Names:Hbor_19730 EMBL ADQ67539.1OrganismHalogeometricu Xenopus tropicalis (Western clawed frog) m borinquense DSM 11551 ARP33947_P050 Q5XGE1_XENTR Hypothetical LOC496517 (Silurana tropicalis) 871 84.00% LOC100037891 ARP33100_T100 Q6IR64_XENLA MGC82290 protein Xenopus laevis (African clawed frog) 225 100.00% Xenopus tropicalis (Western clawed frog) LOC100037891 ARP33100_T100 A4IGQ7_XENTR LOC100037891 protein (Silurana tropicalis) 221 100.00%

Influenza virus NS1A‐binding protein homolog LOC100037891 ARP33100_T100 NS1BP_XENLA (NS1‐BP) (NS1‐binding protein homolog) Xenopus laevis (African clawed frog) 638 100.00% Putative uncharacterized protein Xenopus tropicalis (Western clawed frog) echdc2 ARP48828_P050 B7ZU88_XENTR LOC100135206 (Silurana tropicalis) 294 100.00% Xenopus tropicalis (Western clawed frog) echdc2 ARP48828_P050 A9ULH7_XENTR LOC100135206 protein (Silurana tropicalis) 294 100.00% Trip13 ARP35724_T100 A2VD64_XENLA LOC100037172 protein Xenopus laevis (African clawed frog) 352 85.00% Xenopus tropicalis (Western clawed frog) Trip13 ARP35724_T100 Q6P4W8_XENTR Thyroid hormone receptor interactor 13 (Silurana tropicalis) 432 78.00% BPNT1 ARP58597_P050 Q6DCL1_XENLA MGC82412 protein Xenopus laevis (African clawed frog) 308 91.00% GF13007 ARP37747_T100 Q91708_XENLA C4SR protein Xenopus laevis (African clawed frog) 337 100.00% GF13007 ARP37747_T100 Q5XGW8_XENLA LOC495123 protein Xenopus laevis (African clawed frog) 344 100.00% Xenopus tropicalis (Western clawed frog) GF13007 ARP37747_T100 B4F729_XENTR Putative uncharacterized protein (Silurana tropicalis) 356 100.00% GF13007 ARP37747_T100 A3KND4_XENLA C4SR protein Xenopus laevis (African clawed frog) 337 100.00% Fbxl20 ARP43096_P050 Q6DCN6_XENLA MGC81000 protein Xenopus laevis (African clawed frog) 436 76.00% PYCR1 ARP54937_P050 Q6INR2_XENLA MGC81282 protein Xenopus laevis (African clawed frog) 320 100.00% Pyrroline‐5‐carboxylate reductase family, Xenopus tropicalis (Western clawed frog) PYCR1 ARP54937_P050 Q28C85_XENTR member 2 (Silurana tropicalis) 320 100.00% Xenopus tropicalis (Western clawed frog) PYCR1 ARP54937_P050 A9UM99_XENTR LOC100135284 protein (Silurana tropicalis) 320 85.00% ORF Names:GSPATT00027763001 EMBL CAK56733.1OrganismParamecium NIMA‐family kinase Nek6 (Nek6 protein) tetraurelia ARP48999_P050 Q7ZSX4_XENLA (Nek6‐prov protein) Xenopus laevis (African clawed frog) 310 100.00% ORF Names:GSPATT00027763001 EMBL CAK56733.1OrganismParamecium tetraurelia ARP48999_P050 Q6IU13_XENLA NIMA‐family kinase Nek7 (Nek7 protein) Xenopus laevis (African clawed frog) 302 100.00% ORF Names:GSPATT00027763001 EMBL NIMA (Never in mitosis gene a)‐related CAK56733.1OrganismParamecium expressed kinase 6 (NIMA (Never in mitosis Xenopus tropicalis (Western clawed frog) tetraurelia ARP48999_P050 Q6DIX9_XENTR gene a)‐related kinase 6) (Silurana tropicalis) 310 100.00% ORF Names:GSPATT00027763001 EMBL CAK56733.1OrganismParamecium Xenopus tropicalis (Western clawed frog) tetraurelia ARP48999_P050 Q0IHX5_XENTR Putative uncharacterized protein MGC145434 (Silurana tropicalis) 302 100.00% ORF Names:GSPATT00027763001 EMBL CAK56733.1OrganismParamecium tetraurelia ARP48999_P050 A1L2I8_XENLA LOC100036860 protein Xenopus laevis (African clawed frog) 310 100.00% ORF Names:GSPATT00027763001 EMBL CAK56733.1OrganismParamecium tetraurelia ARP48999_P050 Q6IRQ7_XENLA MGC81499 protein Xenopus laevis (African clawed frog) 297 78.00% ORF Names:GSPATT00027763001 EMBL CAK56733.1OrganismParamecium Xenopus tropicalis (Western clawed frog) tetraurelia ARP48999_P050 Q66IH7_XENTR MGC89594 protein (Silurana tropicalis) 297 78.00% ORF Names:GSPATT00027763001 EMBL Cyclin‐dependent kinase 2 (EC 2.7.11.22) CAK56733.1OrganismParamecium (CDC2 homolog Eg1 protein kinase) (Cell tetraurelia ARP48999_P050 CDK2_XENLA division protein kinase 2) Xenopus laevis (African clawed frog) 297 78.00%

ZFP37 ARP32944_P050 ZO20_XENLA Oocyte zinc finger protein XlCOF20 (Fragment) Xenopus laevis (African clawed frog) 247 91.00% Xenopus tropicalis (Western clawed frog) ZFP37 ARP32944_P050 B0BMG1_XENTR LOC779587 protein (Silurana tropicalis) 438 83.00% ARP32844_P050 Q6DDP9_XENLA Wdhd1 protein (Fragment) Xenopus laevis (African clawed frog) 871 85.00% ARP32844_P050 Q2TAV8_XENLA Wdhd1 protein Xenopus laevis (African clawed frog) 1127 85.00% WD repeat and HMG‐box DNA‐binding protein 1 (Acidic nucleoplasmic DNA‐binding protein ARP32844_P050 WDHD1_XENLA 1) (And‐1) Xenopus laevis (African clawed frog) 1127 85.00%

ORF Names:GSTENG00034904001 EMBL CAG12585.1OrganismTetraodon nigroviridis (Green puffer) ARP33756_P050 Q4FZM0_XENLA LOC733328 protein (Fragment) Xenopus laevis (African clawed frog) 471 78.00%

ORF Names:GSTENG00034904001 EMBL CAG12585.1OrganismTetraodon nigroviridis (Green puffer) ARP33756_P050 A2VD55_XENLA LOC733328 protein (Fragment) Xenopus laevis (African clawed frog) 561 78.00% Ubiquitin carboxyl‐terminal hydrolase 12‐B (EC 3.4.19.12) (Deubiquitinating enzyme 12‐B) (Ubiquitin thiolesterase 12‐B) (Ubiquitin‐ usp12a ARP55812_P050 UB12B_XENLA specific‐processing protease 12‐B) Xenopus laevis (African clawed frog) 370 100.00%

Ubiquitin carboxyl‐terminal hydrolase 12‐A (EC 3.4.19.12) (Deubiquitinating enzyme 12‐A) (Ubiquitin thiolesterase 12‐A) (Ubiquitin‐ usp12a ARP55812_P050 UB12A_XENLA specific‐processing protease 12‐A) Xenopus laevis (African clawed frog) 370 100.00% usp12a ARP55812_P050 Q7ZXZ5_XENLA Usp46‐prov protein Xenopus laevis (African clawed frog) 249 91.00% Xenopus tropicalis (Western clawed frog) usp12a ARP55812_P050 A9JTY0_XENTR LOC100127879 protein (Silurana tropicalis) 369 91.00% ARP48056_P050 Q63ZQ6_XENLA LOC494753 protein Xenopus laevis (African clawed frog) 845 92.00% ARP48056_P050 Q9DGR1_XENLA Homolog of human MT‐SP1 Xenopus laevis (African clawed frog) 845 84.00% ARP48056_P050 Q6GR54_XENLA St14‐A‐prov protein Xenopus laevis (African clawed frog) 845 84.00% Pax6 ARP32741_P050 Q788U0_XENLA Pax‐6 (Fragment) Xenopus laevis (African clawed frog) 95 84.00% Pax6 ARP32741_P050 P70053_XENLA XLPAX6 Xenopus laevis (African clawed frog) 407 84.00% Xenopus tropicalis (Western clawed frog) ARP56908_P050 Q6DJ11_XENTR Glutaredoxin 5 (Silurana tropicalis) 154 85.00% ARP56908_P050 Q4FZP8_XENLA MGC116473 protein Xenopus laevis (African clawed frog) 154 85.00% ARP56908_P050 Q6IRP1_XENLA Grx5‐prov protein (Fragment) Xenopus laevis (African clawed frog) 150 78.00% ARP56908_P050 A5D8L5_XENLA Putative uncharacterized protein Xenopus laevis (African clawed frog) 154 78.00%

ORF Names:TRIADDRAFT_27180 EMBL EDV24247.1OrganismTrichoplax adhaerens (Trichoplax reptans) ARP35461_T100 Q6NTX7_XENLA Kcnab2 protein Xenopus laevis (African clawed frog) 353 100.00%

ORF Names:TRIADDRAFT_27180 EMBL EDV24247.1OrganismTrichoplax Voltage‐gated potassium channel subunit beta‐ adhaerens (Trichoplax reptans) ARP35461_T100 KCAB2_XENLA 2 (K(+) channel subunit beta‐2) (Kv‐beta‐2) Xenopus laevis (African clawed frog) 367 100.00%

ORF Names:TRIADDRAFT_27180 EMBL EDV24247.1OrganismTrichoplax Potassium voltage‐gated channel, shaker‐ Xenopus tropicalis (Western clawed frog) adhaerens (Trichoplax reptans) ARP35461_T100 Q28EG4_XENTR related subfamily, beta member 1 (Silurana tropicalis) 400 76.00% Voltage‐dependent calcium channel gamma‐8 Xenopus tropicalis (Western clawed frog) Cacng4 ARP35236_P050 Q0VFK5_XENTR subunit (Silurana tropicalis) 342 92.00% Xenopus tropicalis (Western clawed frog) P100947_T100 Q28IY7_XENTR Jun B proto‐oncogene (Silurana tropicalis) 307 100.00% P100947_T100 Q6INQ8_XENLA MGC81322 protein Xenopus laevis (African clawed frog) 302 85.00% P100947_T100 A0JMS2_XENLA Junb protein Xenopus laevis (African clawed frog) 295 85.00% P100947_T100 Q9PVZ1_XENLA C‐Jun protein Xenopus laevis (African clawed frog) 312 78.00% P100947_T100 Q9PVZ0_XENLA C‐Jun protein Xenopus laevis (African clawed frog) 314 78.00% P100947_T100 Q8AVE4_XENLA Jun protein Xenopus laevis (African clawed frog) 312 78.00% P100947_T100 Q6GLS7_XENLA C‐Jun protein Xenopus laevis (African clawed frog) 314 78.00% P100947_T100 Q68FJ3_XENLA MGC86303 protein Xenopus laevis (African clawed frog) 299 78.00% Xenopus tropicalis (Western clawed frog) trnt1 ARP40819_T100 A9UMB0_XENTR LOC100135294 protein (Silurana tropicalis) 405 92.00% Xenopus tropicalis (Western clawed frog) trnt1 ARP40819_T100 Q6P873_XENTR tRNA nucleotidyl transferase, CCA‐adding, 1 (Silurana tropicalis) 405 85.00% trnt1 ARP40819_T100 Q32NP6_XENLA MGC130991 protein Xenopus laevis (African clawed frog) 419 85.00% trnt1 ARP40819_T100 Q8AXB8_XENLA ATP(CTP):tRNA nucleotidyltransferase Xenopus laevis (African clawed frog) 428 78.00% trnt1 ARP40819_T100 A8E5Z2_XENLA LOC398421 protein Xenopus laevis (African clawed frog) 419 78.00% BEST1 ARP50109_P050 Q7ZZK4_XENLA Bestrophin‐2b Xenopus laevis (African clawed frog) 512 100.00% BEST1 ARP50109_P050 Q7ZT25_XENLA Bestrophin‐2a (MGC53680 protein) Xenopus laevis (African clawed frog) 512 100.00% BEST1 ARP50109_P050 Q5XH45_XENLA VMD2L1 protein Xenopus laevis (African clawed frog) 512 100.00% Xenopus tropicalis (Western clawed frog) BEST1 ARP50109_P050 C4TNR6_XENTR Bestrophin‐3 (Silurana tropicalis) 657 100.00% Xenopus tropicalis (Western clawed frog) BEST1 ARP50109_P050 B1WBH4_XENTR Best4 protein (Silurana tropicalis) 514 100.00% Xenopus tropicalis (Western clawed frog) BEST1 ARP50109_P050 C4TNR5_XENTR Bestrophin‐1 (Silurana tropicalis) 670 92.00% Xenopus tropicalis (Western clawed frog) BEST1 ARP50109_P050 Q6P851_XENTR Bestrophin 2 (Novel protein similar to vmd2l1) (Silurana tropicalis) 510 92.00% C7orf42 ARP47385_P050 Q7SZ86_XENLA MGC64431 protein Xenopus laevis (African clawed frog) 320 91.00% Xenopus tropicalis (Western clawed frog) C7orf42 ARP47385_P050 CG042_XENTR UPF0458 protein C7orf42 homolog (Silurana tropicalis) 315 91.00% C7orf42 ARP47385_P050 CG042_XENLA UPF0458 protein C7orf42 homolog Xenopus laevis (African clawed frog) 315 91.00% C7orf42 ARP47385_P050 Q7SZ85_XENLA MGC64441 protein Xenopus laevis (African clawed frog) 315 83.00% Xenopus tropicalis (Western clawed frog) ARP38595_T100 B0JZE3_XENTR Foxg1 protein (Silurana tropicalis) 432 100.00% Forkhead box protein G1 (FoxG1) (Brain factor 1) (BF‐1) (xBF‐1) (xBF1) (Forkhead protein 4) foxg1 ARP38595_T100 FOXG1_XENLA (FKH‐4) (xFKH4) Xenopus laevis (African clawed frog) 436 92.00% Calcium‐binding mitochondrial carrier protein SCaMC‐1 (Small calcium‐binding mitochondrial carrier protein 1) (Solute carrier Xenopus tropicalis (Western clawed frog) SLC25A24 ARP43937_T100 SCMC1_XENTR family 25 member 24) (Silurana tropicalis) 473 85.00%

Calcium‐binding mitochondrial carrier protein SCaMC‐1‐B (Small calcium‐binding mitochondrial carrier protein 1‐B) (Solute SLC25A24 ARP43937_T100 SCM1B_XENLA carrier family 25 member 24‐B) Xenopus laevis (African clawed frog) 473 85.00% Calcium‐binding mitochondrial carrier protein SCaMC‐1‐A (Small calcium‐binding mitochondrial carrier protein 1‐A) (Solute SLC25A24 ARP43937_T100 SCM1A_XENLA carrier family 25 member 24‐A) Xenopus laevis (African clawed frog) 473 85.00% Xenopus tropicalis (Western clawed frog) ARP34132_T100 Q0P4K9_XENTR Rcor3 protein (Fragment) (Silurana tropicalis) 456 100.00% PDE4B ARP56256_P050 Q6GM46_XENLA MGC83972 protein Xenopus laevis (African clawed frog) 721 76.00%

ORF Names:v1g228721OrganismNematostel la vectensis (Starlet sea anemone) ARP43765_P050 Q6GQC7_XENLA MGC80162 protein Xenopus laevis (African clawed frog) 453 91.00%

ORF Names:v1g228721OrganismNematostel Xenopus tropicalis (Western clawed frog) la vectensis (Starlet sea anemone) ARP43765_P050 B4F6L7_XENTR Slc41a2 protein (Silurana tropicalis) 559 91.00%

ORF Names:v1g228721OrganismNematostel la vectensis (Starlet sea anemone) ARP43765_P050 S41A2_XENLA Solute carrier family 41 member 2 Xenopus laevis (African clawed frog) 561 91.00%

ORF Names:GSTENG00009129001 EMBL CAF93480.1OrganismTetraodon Xenopus tropicalis (Western clawed frog) nigroviridis (Green puffer) ARP34501_P050 B7ZSN5_XENTR T‐box 20 (Silurana tropicalis) 440 85.00%

ORF Names:GSTENG00009129001 EMBL CAF93480.1OrganismTetraodon nigroviridis (Green puffer) ARP34501_P050 B7ZQT9_XENLA T‐box 20 Xenopus laevis (African clawed frog) 441 85.00%

ORF Names:GSTENG00009129001 EMBL CAF93480.1OrganismTetraodon T‐box transcription factor TBX20 (T‐box Xenopus tropicalis (Western clawed frog) nigroviridis (Green puffer) ARP34501_P050 TBX20_XENTR protein 20) (Silurana tropicalis) 440 85.00%

ORF Names:GSTENG00009129001 EMBL CAF93480.1OrganismTetraodon T‐box transcription factor TBX20 (T‐box nigroviridis (Green puffer) ARP34501_P050 TBX20_XENLA protein 20) Xenopus laevis (African clawed frog) 441 85.00% Pck2 ARP32801_P050 Q7ZWK0_XENLA Pck1‐prov protein Xenopus laevis (African clawed frog) 622 85.00% Pck2 ARP32801_P050 Q7ZXZ8_XENLA PCK2 protein (Fragment) Xenopus laevis (African clawed frog) 638 78.00% Phosphoenolpyruvate carboxykinase 1, Xenopus tropicalis (Western clawed frog) Pck2 ARP32801_P050 Q6P4W1_XENTR cytosolic (Silurana tropicalis) 604 78.00% Pck2 ARP32801_P050 Q6INJ3_XENLA PCK2 protein Xenopus laevis (African clawed frog) 643 78.00% Phosphoenolpyruvate carboxykinase 2 Xenopus tropicalis (Western clawed frog) Pck2 ARP32801_P050 Q28I57_XENTR (Mitochondrial) (Silurana tropicalis) 604 78.00% Pck2 ARP32801_P050 Q6PF62_XENLA MGC68864 protein Xenopus laevis (African clawed frog) 622 78.00% Suppressor of variegation 4‐20‐like protein 1 Suv420h1beta ARP34567_T100 B2L4S6_XENBO beta (Fragment) Xenopus borealis (Kenyan clawed frog) 62 100.00% Histone‐lysine N‐methyltransferase SUV420H1‐ B (EC 2.1.1.43) (Suppressor of variegation 4‐ 20 homolog 1‐B) (Su(var)4‐20 homolog 1‐B) Suv420h1beta ARP34567_T100 S421B_XENLA (Suv4‐20h1‐B) Xenopus laevis (African clawed frog) 785 100.00% Histone‐lysine N‐methyltransferase SUV420H1‐ A (EC 2.1.1.43) (Suppressor of variegation 4‐ 20 homolog 1‐A) (Su(var)4‐20 homolog 1‐A) Suv420h1beta ARP34567_T100 S421A_XENLA (Suv4‐20h1‐A) Xenopus laevis (African clawed frog) 855 100.00% ORF Names:ACLA_010000 EMBL EAW12577.1OrganismAspergillus clavatus ARP51766_P050 Q6PAD1_XENLA MGC68788 protein Xenopus laevis (African clawed frog) 500 100.00% ORF Names:ACLA_010000 EMBL EAW12577.1OrganismAspergillus clavatus ARP51766_P050 Q6P701_XENLA MGC68458 protein Xenopus laevis (African clawed frog) 500 100.00% ORF Names:ACLA_010000 EMBL EAW12577.1OrganismAspergillus clavatus ARP51766_P050 Q6GM94_XENLA MGC68458 protein Xenopus laevis (African clawed frog) 500 100.00% ORF Names:ACLA_010000 EMBL EAW12577.1OrganismAspergillus Xenopus tropicalis (Western clawed frog) clavatus ARP51766_P050 B2GUT2_XENTR LOC100158654 protein (Silurana tropicalis) 500 100.00%

ORF Names:v1g105157OrganismNematostel Xenopus tropicalis (Western clawed frog) la vectensis (Starlet sea anemone) ARP47404_P050 Q2TLY8_XENTR Macoilin (Silurana tropicalis) 661 100.00%

ORF Names:v1g105157OrganismNematostel la vectensis (Starlet sea anemone) ARP47404_P050 Q2TLY7_XENLA Macoilin Xenopus laevis (African clawed frog) 668 100.00% Xenopus tropicalis (Western clawed frog) ARP36763_P050 B5DDZ7_XENTR Putative uncharacterized protein (Silurana tropicalis) 486 100.00% Xenopus tropicalis (Western clawed frog) ARP36763_P050 B2GU78_XENTR LOC100158521 protein (Silurana tropicalis) 583 100.00% ARP36763_P050 A8WH49_XENLA LOC100127255 protein (Fragment) Xenopus laevis (African clawed frog) 498 100.00%

ARP56227_P050 Q4QR44_XENLA MGC114789 protein (MGC130892 protein) Xenopus laevis (African clawed frog) 130 100.00% Xenopus tropicalis (Western clawed frog) ARP56227_P050 A4IH66_XENTR LOC100125111 protein (Silurana tropicalis) 130 100.00% Fn3krp ARP58624_P050 Q05AX1_XENLA Fn3k protein Xenopus laevis (African clawed frog) 332 84.00% Fn3krp ARP58624_P050 Q6GLM6_XENLA MGC84705 protein Xenopus laevis (African clawed frog) 310 76.00% Xenopus tropicalis (Western clawed frog) Fn3krp ARP58624_P050 Q0VFK9_XENTR Fructosamine 3 kinase (Silurana tropicalis) 310 76.00% ARP34378_T100 Q6DCU0_XENLA MGC80746 protein Xenopus laevis (African clawed frog) 280 92.00% Xenopus tropicalis (Western clawed frog) ARP34378_T100 Q6DIX2_XENTR Four and a half LIM domains 1 (Silurana tropicalis) 296 85.00% ARP34378_T100 Q66KN8_XENLA MGC85575 protein Xenopus laevis (African clawed frog) 280 85.00% ORF Names:NFIA_056300 EMBL EAW16281.1OrganismNeosartorya fischeri (strain ATCC 1020 / DSM 3700 / FGSC A1164 / NRRL 181) (Aspergillus Xenopus tropicalis (Western clawed frog) fischerianus) ARP43566_T100 Q6P339_XENTR Decr2‐prov protein (Fragment) (Silurana tropicalis) 313 100.00% ORF Names:NFIA_056300 EMBL EAW16281.1OrganismNeosartorya fischeri (strain ATCC 1020 / DSM 3700 / FGSC A1164 / NRRL 181) (Aspergillus fischerianus) ARP43566_T100 Q6GR01_XENLA MGC82265 protein Xenopus laevis (African clawed frog) 302 100.00%

ORF Names:zgc:158517 ZFIN ZDB‐GENE‐ 070112‐222OrganismDanio rerio Xenopus tropicalis (Western clawed frog) (Zebrafish) (Brachydanio rerio) ARP47733_P050 B3DLR8_XENTR LOC100170538 protein (Silurana tropicalis) 386 90.00%

ORF Names:zgc:158517 ZFIN ZDB‐GENE‐ 070112‐222OrganismDanio rerio Xenopus tropicalis (Western clawed frog) (Zebrafish) (Brachydanio rerio) ARP47733_P050 B2GU19_XENTR LOC100158487 protein (Silurana tropicalis) 302 90.00%

ORF Names:zgc:158517 ZFIN ZDB‐GENE‐ 070112‐222OrganismDanio rerio Xenopus tropicalis (Western clawed frog) (Zebrafish) (Brachydanio rerio) ARP47733_P050 B1H2A9_XENTR LOC100145374 protein (Silurana tropicalis) 302 90.00%

ORF Names:zgc:158517 ZFIN ZDB‐GENE‐ 070112‐222OrganismDanio rerio Xenopus tropicalis (Western clawed frog) (Zebrafish) (Brachydanio rerio) ARP47733_P050 B1H2B3_XENTR Putative uncharacterized protein (Silurana tropicalis) 507 78.00% Serine/threonine‐protein kinase Chk1 (xChk1) ARP32588_P050 CHK1_XENLA (EC 2.7.11.1) Xenopus laevis (African clawed frog) 474 91.00% senp1 ARP55082_P050 D0G0B1_XENLA Sentrin specific protease 1b Xenopus laevis (African clawed frog) 616 76.00% supt16h ARP31526_T100 Q5FWP3_XENLA LOC733160 protein (Fragment) Xenopus laevis (African clawed frog) 474 92.00% supt16h ARP31526_T100 B7ZQW8_XENLA SUPT16H protein Xenopus laevis (African clawed frog) 1035 85.00% FACT complex subunit SPT16 (DNA unwinding factor 140 kDa subunit) (DUF140) (Facilitates chromatin transcription complex subunit supt16h ARP31526_T100 SP16H_XENLA spt16) Xenopus laevis (African clawed frog) 1035 85.00% Xenopus tropicalis (Western clawed frog) VEZF1 ARP35830_P050 Q6DEW9_XENTR Vascular endothelial zinc finger 1 (Silurana tropicalis) 512 100.00% VEZF1 ARP35830_P050 Q6DDS3_XENLA Znf161‐prov protein Xenopus laevis (African clawed frog) 512 100.00% VEZF1 ARP35830_P050 Q0VGX3_XENLA Vezf1 protein Xenopus laevis (African clawed frog) 511 100.00% Endoplasmic reticulum nucleotide sugar Xenopus tropicalis (Western clawed frog) LOC100036915 ARP43908_T100 B7ZTN3_XENTR transporter (Silurana tropicalis) 342 100.00%

LOC100036915 ARP43908_T100 B7FEW0_XENLA Putative uncharacterized protein (Fragment) Xenopus laevis (African clawed frog) 347 100.00% LOC100036915 ARP43908_T100 A1L2P9_XENLA LOC100036915 protein (Fragment) Xenopus laevis (African clawed frog) 347 100.00% Xenopus tropicalis (Western clawed frog) LOC100036915 ARP43908_T100 S35B1_XENTR Solute carrier family 35 member B1 (Silurana tropicalis) 323 100.00% Solute carrier family 35 member B1 (Endoplasmic reticulum nucleotide sugar LOC100036915 ARP43908_T100 S35B1_XENLA transporter 1) Xenopus laevis (African clawed frog) 320 100.00% ARP35490_P050 Q6GM25_XENLA MGC84022 protein Xenopus laevis (African clawed frog) 231 78.00% ARP35490_P050 Q640X4_XENLA Kcnip2 protein Xenopus laevis (African clawed frog) 231 78.00% ARP35490_P050 Q4V7N5_XENLA MGC115522 protein Xenopus laevis (African clawed frog) 233 78.00% Xenopus tropicalis (Western clawed frog) ARP35490_P050 A9UM33_XENTR LOC100135241 protein (Silurana tropicalis) 259 76.00% Xenopus tropicalis (Western clawed frog) Kif1b ARP33900_P050 A7MC47_XENTR LOC100127546 protein (Fragment) (Silurana tropicalis) 300 100.00% Iron‐responsive element‐binding protein 2 Xenopus tropicalis (Western clawed frog) ireb2 ARP40509_P050 IREB2_XENTR (IRE‐BP 2) (Silurana tropicalis) 957 92.00% Iron‐responsive element‐binding protein 2 ireb2 ARP40509_P050 IREB2_XENLA (IRE‐BP 2) Xenopus laevis (African clawed frog) 955 92.00% ORF Names:CpipJ_CPIJ016589 EMBL EDS44151.1OrganismCulex quinquefasciatus (Southern house mosquito) (Culex pungens) ARP32102_P050 Q5EAW6_XENLA Xdsh protein Xenopus laevis (African clawed frog) 673 100.00% ORF Names:CpipJ_CPIJ016589 EMBL EDS44151.1OrganismCulex quinquefasciatus (Southern house Segment polarity protein dishevelled homolog Xenopus tropicalis (Western clawed frog) mosquito) (Culex pungens) ARP32102_P050 DVL2_XENTR DVL‐2 (Dishevelled‐2) (DSH homolog 2) (Silurana tropicalis) 732 100.00% ORF Names:CpipJ_CPIJ016589 EMBL EDS44151.1OrganismCulex quinquefasciatus (Southern house Segment polarity protein dishevelled homolog mosquito) (Culex pungens) ARP32102_P050 DVL2_XENLA DVL‐2 (Dishevelled‐2) (DSH homolog 2) (Xdsh) Xenopus laevis (African clawed frog) 736 100.00% ORF Names:CpipJ_CPIJ016589 EMBL EDS44151.1OrganismCulex quinquefasciatus (Southern house Segment polarity protein dishevelled homolog Xenopus tropicalis (Western clawed frog) mosquito) (Culex pungens) ARP32102_P050 DVL3_XENTR DVL‐3 (Dishevelled‐3) (DSH homolog 3) (Silurana tropicalis) 713 92.00% ORF Names:CpipJ_CPIJ016589 EMBL EDS44151.1OrganismCulex quinquefasciatus (Southern house Segment polarity protein dishevelled homolog mosquito) (Culex pungens) ARP32102_P050 DVL3_XENLA DVL‐3 (Dishevelled‐3) (DSH homolog 3) Xenopus laevis (African clawed frog) 717 92.00% ORF Names:CpipJ_CPIJ016589 EMBL EDS44151.1OrganismCulex quinquefasciatus (Southern house Xenopus tropicalis (Western clawed frog) mosquito) (Culex pungens) ARP32102_P050 B1H321_XENTR Dvl1 protein (Silurana tropicalis) 559 92.00% Ordered Locus Names:Ajs_4167Encoded onPlasmid pAOVO01 EMBL ABM44268.1OrganismAcidovorax sp. (strain JS42) ARP40212_T100 Q7ZWY6_XENLA Rpl9‐prov protein Xenopus laevis (African clawed frog) 192 85.00% Xenopus tropicalis (Western clawed frog) epc1 ARP33343_P050 A0JP73_XENTR Epc1 protein (Silurana tropicalis) 627 78.00% ORF Names:PANDA_009456 EMBL EFB28049.1OrganismAiluropoda melanoleuca (Giant panda) ARP35260_P050 KCNK9_XENLA Potassium channel subfamily K member 9 Xenopus laevis (African clawed frog) 374 92.00% Xenopus tropicalis (Western clawed frog) ARP40512_T100 B1H3B2_XENTR Putative uncharacterized protein (Fragment) (Silurana tropicalis) 145 100.00% Xenopus tropicalis (Western clawed frog) ARP40512_T100 TRBP2_XENTR RISC‐loading complex subunit tarbp2 (Silurana tropicalis) 351 100.00% ARP40512_T100 TRBP2_XENLA RISC‐loading complex subunit tarbp2 Xenopus laevis (African clawed frog) 351 100.00% Interferon‐inducible double stranded RNA‐ dependent protein kinase activator A homolog B (Double‐stranded RNA‐binding ARP40512_T100 PRKAB_XENLA protein A) (XlRBPA) Xenopus laevis (African clawed frog) 298 85.00% Interferon‐inducible double stranded RNA‐ dependent protein kinase activator A ARP40512_T100 PRKAA_XENLA homolog A Xenopus laevis (African clawed frog) 309 85.00% Xenopus tropicalis (Western clawed frog) ARP31985_T100 Q28DH4_XENTR Novel protein (Silurana tropicalis) 605 76.00% Xenopus tropicalis (Western clawed frog) ARP40215_T100 RL8_XENTR 60S ribosomal protein L8 (Silurana tropicalis) 257 100.00% ARP40215_T100 RL8_XENLA 60S ribosomal protein L8 Xenopus laevis (African clawed frog) 257 100.00% spry1 ARP50521_P050 Q90ZT6_XENLA LOC398313 protein (Sprouty 2) (Sprouty2) Xenopus laevis (African clawed frog) 314 91.00% Xenopus tropicalis (Western clawed frog) spry1 ARP50521_P050 Q5Y172_XENTR Sprouty1 (Silurana tropicalis) 319 78.00% spry1 ARP50521_P050 B7U6L7_XENLA Sprouty 1 Xenopus laevis (African clawed frog) 319 78.00% spry1 ARP50521_P050 B5MGQ5_XENLA Sprouty1 Xenopus laevis (African clawed frog) 319 78.00% Xenopus tropicalis (Western clawed frog) spry1 ARP50521_P050 A4IGX0_XENTR Spry1 protein (Silurana tropicalis) 319 78.00% spry1 ARP50521_P050 Q90ZT5_XENLA Sprouty2delta Xenopus laevis (African clawed frog) 307 83.00% spry1 ARP50521_P050 Q6GNB0_XENLA LOC398232 protein Xenopus laevis (African clawed frog) 307 83.00% Xenopus tropicalis (Western clawed frog) spry1 ARP50521_P050 Q5Y173_XENTR Sprouty2 (Silurana tropicalis) 314 83.00% Xenopus tropicalis (Western clawed frog) spry1 ARP50521_P050 Q5PRF7_XENTR Sprouty homolog 2 (Silurana tropicalis) 314 83.00% Xenopus tropicalis (Western clawed frog) spry1 ARP50521_P050 Q28GR6_XENTR Sprouty homolog 2 (Drosophila) (Silurana tropicalis) 314 83.00% ACSL4 ARP49774_P050 B3DLM0_XENLA LOC100174803 protein Xenopus laevis (African clawed frog) 670 92.00% Xenopus tropicalis (Western clawed frog) spock3 ARP44921_P050 A4II43_XENTR Spock3 protein (Silurana tropicalis) 433 85.00% ORF Names:PANDA_019426 EMBL EFB24199.1OrganismAiluropoda DDB1‐ and CUL4‐associated factor 12 (WD Xenopus tropicalis (Western clawed frog) melanoleuca (Giant panda) ARP51329_P050 DCA12_XENTR repeat‐containing protein 40A) (Silurana tropicalis) 446 84.00% ORF Names:PANDA_019426 EMBL EFB24199.1OrganismAiluropoda DDB1‐ and CUL4‐associated factor 12‐B (WD melanoleuca (Giant panda) ARP51329_P050 DC12B_XENLA repeat‐containing protein 40A‐B) Xenopus laevis (African clawed frog) 442 84.00% ORF Names:PANDA_019426 EMBL EFB24199.1OrganismAiluropoda DDB1‐ and CUL4‐associated factor 12‐A (WD melanoleuca (Giant panda) ARP51329_P050 DC12A_XENLA repeat‐containing protein 40A‐A) Xenopus laevis (African clawed frog) 446 84.00% Xenopus tropicalis (Western clawed frog) lamc1 ARP58234_P050 LAMC1_XENTR Laminin subunit gamma‐1 (Silurana tropicalis) 1592 91.00% Xenopus tropicalis (Western clawed frog) dpp6b ARP44868_P050 A4IIX6_XENTR LOC100125080 protein (Silurana tropicalis) 846 92.00% Phosphoinositide‐3‐kinase, regulatory subunit Xenopus tropicalis (Western clawed frog) Pik3r5 ARP55011_P050 Q28C03_XENTR 5, p101 (Silurana tropicalis) 877 92.00%

Phosphoinositide 3‐kinase regulatory subunit Pik3r5 ARP55011_P050 PI3R5_XENLA 5 (PI3‐kinase regulatory subunit 5) Xenopus laevis (African clawed frog) 879 85.00%

Putative nuclease HARBI1 (EC 3.1.‐.‐) Harbi1 ARP55708_P050 HARB1_XENLA (Harbinger transposase‐derived nuclease) Xenopus laevis (African clawed frog) 347 91.00% Xenopus tropicalis (Western clawed frog) tbx3 ARP33412_T100 Q4KKX3_XENTR T‐box 3 (Silurana tropicalis) 701 78.00% Xenopus tropicalis (Western clawed frog) ARP38810_T100 Q08D59_XENTR Transcription factor EB (Silurana tropicalis) 433 84.00% Micophthalmia‐associated transcription factor ARP38810_T100 Q76DN5_XENLA type M Xenopus laevis (African clawed frog) 392 76.00% Micophthalmia‐associated transcription factor ARP38810_T100 Q76DN4_XENLA type A Xenopus laevis (African clawed frog) 483 76.00% Eukaryotic translation initiation factor 4E Xenopus tropicalis (Western clawed frog) EIF4E3 ARP41168_P050 B1WAS5_XENTR member 3 (Silurana tropicalis) 218 100.00% Eukaryotic translation initiation factor 4E type 3 (eIF‐4E type 3) (eIF‐4E3) (eIF4E type 3) Xenopus tropicalis (Western clawed frog) EIF4E3 ARP41168_P050 IF4E3_XENTR (eIF4E‐3) (Silurana tropicalis) 218 100.00% Eukaryotic translation initiation factor 4E type 3‐B (eIF‐4E type 3‐B) (eIF‐4E3‐B) (eIF4E type 3‐ EIF4E3 ARP41168_P050 I4E3B_XENLA B) (eIF4E‐3‐B) Xenopus laevis (African clawed frog) 218 100.00% Eukaryotic translation initiation factor 4E type 3‐A (eIF‐4E type 3‐A) (eIF‐4E3‐A) (eIF4E type 3‐ EIF4E3 ARP41168_P050 I4E3A_XENLA A) (eIF4E‐3‐A) Xenopus laevis (African clawed frog) 218 100.00% Hist1h2bj ARP56220_P050 Q92131_XENLA Histone H2B Xenopus laevis (African clawed frog) 126 92.00% Hist1h2bj ARP56220_P050 Q92130_XENLA Histone H2B Xenopus laevis (African clawed frog) 126 92.00% Xenopus tropicalis (Western clawed frog) Hist1h2bj ARP56220_P050 Q6AZK7_XENTR Histone 1, H2bk (Silurana tropicalis) 126 92.00% Xenopus tropicalis (Western clawed frog) Hist1h2bj ARP56220_P050 Q28D68_XENTR Histone 2, H2bf (Silurana tropicalis) 126 92.00% Hist1h2bj ARP56220_P050 H2B11_XENLA Histone H2B 1.1 (H2B1.1) Xenopus laevis (African clawed frog) 126 92.00% Xenopus tropicalis (Western clawed frog) Hist1h2bj ARP56220_P050 Q28J31_XENTR Histone 1, H2bk (Silurana tropicalis) 126 85.00% Hist1h2bj ARP56220_P050 H2B12_XENLA Histone H2B 1.2 (H2B1.2) Xenopus laevis (African clawed frog) 126 85.00% POLDIP3 ARP41048_P050 Q6GPT4_XENLA MGC82630 protein Xenopus laevis (African clawed frog) 405 85.00% Polymerase (DNA‐directed), delta interacting Xenopus tropicalis (Western clawed frog) POLDIP3 ARP41048_P050 Q6GLF3_XENTR protein 3 (Silurana tropicalis) 367 85.00% POLDIP3 ARP41048_P050 Q566H6_XENLA MGC114944 protein Xenopus laevis (African clawed frog) 395 85.00% Polymerase (DNA‐directed), delta interacting Xenopus tropicalis (Western clawed frog) POLDIP3 ARP41048_P050 Q28CZ1_XENTR protein 3 (Silurana tropicalis) 433 85.00% ARP48210_P050 Q7SYU9_XENLA Ldhba protein Xenopus laevis (African clawed frog) 334 78.00% L‐lactate dehydrogenase B chain (LDH‐B) (EC ARP48210_P050 LDHB_XENLA 1.1.1.27) Xenopus laevis (African clawed frog) 334 78.00% prim1 ARP46013_T100 Q800A4_XENLA Dnapol‐alpha50‐prov protein Xenopus laevis (African clawed frog) 420 85.00% Xenopus tropicalis (Western clawed frog) prim1 ARP46013_T100 Q28CV7_XENTR Primase, polypeptide 1, 49kDa (Silurana tropicalis) 420 85.00% Xenopus tropicalis (Western clawed frog) prim1 ARP46013_T100 Q6NVT9_XENTR Primase, polypeptide 1, 49kDa (Silurana tropicalis) 420 85.00% Xenopus tropicalis (Western clawed frog) ext1b ARP44219_P050 Q6DIQ4_XENTR Exostoses (Multiple) 1 (Silurana tropicalis) 738 92.00% ext1b ARP44219_P050 Q98SV5_XENLA Exostosin (Exostosin 1) Xenopus laevis (African clawed frog) 738 84.00% ext1b ARP44219_P050 Q8QGX3_XENLA XEXT1 Xenopus laevis (African clawed frog) 735 84.00% ext1b ARP44219_P050 Q6DE99_XENLA XEXT1 protein Xenopus laevis (African clawed frog) 735 84.00% ext1b ARP44219_P050 Q52KD9_XENLA XEXT1 protein Xenopus laevis (African clawed frog) 738 84.00% ORF Names:GSPATT00012129001 EMBL CAK76577.1OrganismParamecium U1 small nuclear ribonucleoprotein 70 kDa Xenopus tropicalis (Western clawed frog) tetraurelia ARP38954_P050 RU17_XENTR (U1 snRNP 70 kDa) (U1‐70K) (snRNP70) (Silurana tropicalis) 471 85.00% ORF Names:GSPATT00012129001 EMBL CAK76577.1OrganismParamecium tetraurelia ARP38954_P050 Q640I1_XENLA LOC494667 protein Xenopus laevis (African clawed frog) 135 84.00% ORF Names:GSPATT00012129001 EMBL CAK76577.1OrganismParamecium tetraurelia ARP38954_P050 A1L1H0_XENLA LOC100036839 protein Xenopus laevis (African clawed frog) 1529 84.00% ORF Names:GSPATT00012129001 EMBL CAK76577.1OrganismParamecium tetraurelia ARP38954_P050 Q63ZQ9_XENLA LOC494751 protein Xenopus laevis (African clawed frog) 2234 76.00% FTSJ1 ARP49131_P050 Q801N2_XENLA Ftsj1‐prov protein Xenopus laevis (African clawed frog) 130 92.00% Xenopus tropicalis (Western clawed frog) FTSJ1 ARP49131_P050 Q28DF0_XENTR FtsJ homolog 1 (E. coli) (Silurana tropicalis) 335 92.00% Xenopus tropicalis (Western clawed frog) Shroom2 ARP35054_P050 SHRM2_XENTR Protein Shroom2 (Protein Apxl) (Silurana tropicalis) 1726 85.00% Shroom2 ARP35054_P050 SHRM3_XENLA Protein Shroom3 (Shroom‐like protein) Xenopus laevis (African clawed frog) 1788 90.00%

Ordered Locus Names:Veis_3539OrganismVerminephr obacter eiseniae (strain EF01‐2) ARP53112_P050 Q6NRB2_XENLA MGC84587 protein Xenopus laevis (African clawed frog) 328 92.00%

Ordered Locus Names:Veis_3539OrganismVerminephr Xenopus tropicalis (Western clawed frog) obacter eiseniae (strain EF01‐2) ARP53112_P050 Q5BKJ0_XENTR MGC108315 protein (Silurana tropicalis) 328 92.00%

Ordered Locus Names:Veis_3539OrganismVerminephr obacter eiseniae (strain EF01‐2) ARP53112_P050 Q5XGV0_XENLA LOC495134 protein Xenopus laevis (African clawed frog) 328 92.00% lhx2b ARP35966_T100 Q98SF5_XENLA Lhx2 protein (Fragment) Xenopus laevis (African clawed frog) 96 100.00% lhx2b ARP35966_T100 Q6K1E8_XENLA LIM homeobox protein 2 Xenopus laevis (African clawed frog) 419 100.00% lhx2b ARP35966_T100 B7U6H6_XENLA LHX9 Xenopus laevis (African clawed frog) 399 100.00% LIM/homeobox protein Lhx9 (LIM homeobox lhx2b ARP35966_T100 LHX9_XENLA protein 9) Xenopus laevis (African clawed frog) 331 100.00% lhx2b ARP35966_T100 Q98SF7_XENLA Lhx9 protein (Fragment) Xenopus laevis (African clawed frog) 217 92.00%

ORF Names:v1g167719OrganismNematostel Probable ATP‐dependent RNA helicase ddx6 Xenopus tropicalis (Western clawed frog) la vectensis (Starlet sea anemone) ARP36368_T100 DDX6_XENTR (EC 3.6.4.13) (DEAD box protein 6) (Silurana tropicalis) 481 100.00% ORF ATP‐dependent RNA helicase ddx6 (EC Names:v1g167719OrganismNematostel 3.6.4.13) (ATP‐dependent RNA helicase p54) la vectensis (Starlet sea anemone) ARP36368_T100 DDX6_XENLA (P54H) (Xp54) (DEAD box protein 6) Xenopus laevis (African clawed frog) 481 100.00% ORF Names:GSPATT00022996001 EMBL CAK89823.1OrganismParamecium tetraurelia ARP31995_P050 Q6GR23_XENLA MGC81304 protein Xenopus laevis (African clawed frog) 460 92.00% ORF Names:GSPATT00022996001 EMBL CAK89823.1OrganismParamecium tetraurelia ARP31995_P050 Q6DD26_XENLA Putative uncharacterized protein Xenopus laevis (African clawed frog) 460 92.00% ORF Names:GSPATT00022996001 EMBL CAK89823.1OrganismParamecium Xenopus tropicalis (Western clawed frog) tetraurelia ARP31995_P050 Q5BL51_XENTR Interferon regulatory factor 6, gene 2 (Silurana tropicalis) 365 92.00% ORF Names:GSPATT00022996001 EMBL CAK89823.1OrganismParamecium Novel protein similar to interferon regulatory Xenopus tropicalis (Western clawed frog) tetraurelia ARP31995_P050 Q28ES2_XENTR factor transcription factor (Silurana tropicalis) 460 92.00% ORF Names:GSPATT00022996001 EMBL CAK89823.1OrganismParamecium Novel protein similar to interferon regulatory Xenopus tropicalis (Western clawed frog) tetraurelia ARP31995_P050 Q28ET3_XENTR factor transcription factor (Silurana tropicalis) 460 84.00% ORF Names:GSPATT00022996001 EMBL CAK89823.1OrganismParamecium Xenopus tropicalis (Western clawed frog) tetraurelia ARP31995_P050 B0JZ05_XENTR Interferon regulatory factor 6 (Silurana tropicalis) 460 84.00% ORF Names:GSPATT00022996001 EMBL CAK89823.1OrganismParamecium tetraurelia ARP31995_P050 Q2VPM3_XENLA XIRF‐6 protein Xenopus laevis (African clawed frog) 459 76.00% ORF Names:GSPATT00022996001 EMBL CAK89823.1OrganismParamecium tetraurelia ARP31995_P050 O57578_XENLA XIRF‐6 protein Xenopus laevis (African clawed frog) 459 76.00% PPAP2A ARP42721_T100 Q6GP13_XENLA MGC80748 protein Xenopus laevis (African clawed frog) 284 75.00% Xenopus tropicalis (Western clawed frog) PPAP2A ARP42721_T100 B0BM26_XENTR Ppap2a protein (Silurana tropicalis) 284 75.00% DGCR2 ARP46576_P050 Q6GM11_XENLA MGC84054 protein Xenopus laevis (African clawed frog) 549 85.00% Xenopus tropicalis (Western clawed frog) DGCR2 ARP46576_P050 Q28DK0_XENTR DiGeorge syndrome critical region gene 2 (Silurana tropicalis) 551 85.00% PPP1R13L ARP32825_P050 Q66KF0_XENLA MGC86497 protein Xenopus laevis (African clawed frog) 805 90.00% Novel protein similar to protein phosphatase Xenopus tropicalis (Western clawed frog) PPP1R13L ARP32825_P050 Q28C37_XENTR 1, regulatory (Inhibitor) subunit 13 like (Silurana tropicalis) 798 90.00% wdsub1 ARP43423_P050 B7ZQE0_XENLA Putative uncharacterized protein Xenopus laevis (African clawed frog) 484 100.00% wdsub1 ARP43423_P050 A8WH58_XENLA LOC100127264 protein Xenopus laevis (African clawed frog) 460 100.00% Xenopus tropicalis (Western clawed frog) wdsub1 ARP43423_P050 NOSIP_XENTR ‐interacting protein (Silurana tropicalis) 298 78.00% wdsub1 ARP43423_P050 NOSIP_XENLA Nitric oxide synthase‐interacting protein Xenopus laevis (African clawed frog) 298 78.00% Sdcbp ARP44535_T100 Q7ZYM5_XENLA Sdcbp protein (Sdcbp‐prov protein) Xenopus laevis (African clawed frog) 295 100.00% Xenopus tropicalis (Western clawed frog) Sdcbp ARP44535_T100 Q6DFR3_XENTR Syndecan binding protein (Syntenin) (Silurana tropicalis) 295 100.00% Sdcbp ARP44535_T100 Q66JA3_XENLA MGC81274 protein Xenopus laevis (African clawed frog) 295 100.00% ORF Names:TVAG_028550 EMBL EAY13902.1OrganismTrichomonas vaginalis ARP58125_P050 Q8AVF3_XENLA LOC398536 protein (Fragment) Xenopus laevis (African clawed frog) 618 83.00% ORF Names:TVAG_028550 EMBL EAY13902.1OrganismTrichomonas vaginalis ARP58125_P050 Q7ZWV5_XENLA LOC398495 protein (Fragment) Xenopus laevis (African clawed frog) 622 83.00% Transcription factor Sox‐14 (SRY (sex Xenopus tropicalis (Western clawed frog) Sox14 ARP35711_T100 SOX14_XENTR determining region Y)‐box 14) (Silurana tropicalis) 239 100.00% Transcription factor Sox‐14 (SRY (sex Sox14 ARP35711_T100 SOX14_XENLA determining region Y)‐box 14) Xenopus laevis (African clawed frog) 239 92.00%

ORF Names:BRAFLDRAFT_60330 EMBL EEN62892.1OrganismBranchiostoma Epoxide hydrolase 3 (EC 3.3.‐.‐) (Abhydrolase Xenopus tropicalis (Western clawed frog) floridae (Florida lancelet) (Amphioxus) ARP55651_P050 EPHX3_XENTR domain‐containing protein 9) (Silurana tropicalis) 367 78.00% DNA replication licensing factor mcm7 (CDC47 homolog) (Minichromosome maintenance Xenopus tropicalis (Western clawed frog) ARP36666_P050 MCM7_XENTR protein 7) (Silurana tropicalis) 720 92.00% DNA replication licensing factor mcm7‐A (CDC47 homolog A) (CDC47p) (Minichromosome maintenance protein 7‐A) ARP36666_P050 MCM7A_XENLA (xMCM7‐A) (p90) Xenopus laevis (African clawed frog) 720 85.00% Xenopus tropicalis (Western clawed frog) larp1b ARP34532_T100 B2GUC9_XENTR Larp2 protein (Silurana tropicalis) 991 78.00% 11‐Sep ARP46216_T100 Q6GP91_XENLA LOC443634 protein (Fragment) Xenopus laevis (African clawed frog) 330 100.00% 11‐Sep ARP46216_T100 Q6DCR0_XENLA Sept11‐prov protein Xenopus laevis (African clawed frog) 431 100.00% 11‐Sep ARP46216_T100 Q4QR59_XENLA LOC443634 protein Xenopus laevis (African clawed frog) 429 100.00% Xenopus tropicalis (Western clawed frog) 11‐Sep ARP46216_T100 B1H1Z1_XENTR LOC100125034 protein (Fragment) (Silurana tropicalis) 387 100.00% Xenopus tropicalis (Western clawed frog) 11‐Sep ARP46216_T100 A4IIP3_XENTR LOC100125034 protein (Fragment) (Silurana tropicalis) 340 100.00% 11‐Sep ARP46216_T100 Q66J62_XENLA MGC81799 protein Xenopus laevis (African clawed frog) 430 92.00% Xenopus tropicalis (Western clawed frog) 11‐Sep ARP46216_T100 Q6DIQ2_XENTR Sept6 protein (Fragment) (Silurana tropicalis) 391 92.00% Xenopus tropicalis (Western clawed frog) 11‐Sep ARP46216_T100 B1H3L0_XENTR Sept6 protein (Silurana tropicalis) 431 92.00% Xenopus tropicalis (Western clawed frog) 11‐Sep ARP46216_T100 A4IIW8_XENTR Sept6 protein (Fragment) (Silurana tropicalis) 355 92.00% 11‐Sep ARP46216_T100 B2L5H9_XENBO Septin‐6 beta (Fragment) Xenopus borealis (Kenyan clawed frog) 26 85.00% Xenopus tropicalis (Western clawed frog) 11‐Sep ARP46216_T100 SEPT8_XENTR Septin‐8 (Silurana tropicalis) 427 78.00% 11‐Sep ARP46216_T100 SEP8B_XENLA Septin‐8‐B Xenopus laevis (African clawed frog) 427 78.00% 11‐Sep ARP46216_T100 SEP8A_XENLA Septin‐8‐A Xenopus laevis (African clawed frog) 427 78.00% Xenopus tropicalis (Western clawed frog) si:dkey‐40c11.1 ARP56210_P050 A4IIC8_XENTR LOC100124981 protein (Silurana tropicalis) 465 85.00% ARP35253_P050 Q6AX43_XENLA MGC86234 protein Xenopus laevis (African clawed frog) 806 100.00% ORF Names:CpipJ_CPIJ009396 EMBL EDS32881.1OrganismCulex quinquefasciatus (Southern house Xenopus tropicalis (Western clawed frog) mosquito) (Culex pungens) ARP33346_P050 ING3_XENTR Inhibitor of growth protein 3 (Silurana tropicalis) 417 92.00% ORF Names:CpipJ_CPIJ009396 EMBL EDS32881.1OrganismCulex quinquefasciatus (Southern house mosquito) (Culex pungens) ARP33346_P050 ING3_XENLA Inhibitor of growth protein 3 Xenopus laevis (African clawed frog) 416 92.00% SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily Xenopus tropicalis (Western clawed frog) Smarce1 ARP33313_P050 Q6GLG1_XENTR e, member 1 (Silurana tropicalis) 435 100.00% Smarce1 ARP33313_P050 Q8QG95_XENLA Baf57 Xenopus laevis (African clawed frog) 423 90.00% Smarce1 ARP33313_P050 Q8AVX7_XENLA Smarce1 protein Xenopus laevis (African clawed frog) 402 90.00% Smarce1 ARP33313_P050 Q5XH26_XENLA Smarce1 protein Xenopus laevis (African clawed frog) 423 90.00%

ORF Names:v1g173499OrganismNematostel la vectensis (Starlet sea anemone) ARP53293_P050 Q6DFT9_XENLA MGC78855 protein Xenopus laevis (African clawed frog) 188 100.00%

ORF Names:v1g173499OrganismNematostel Xenopus tropicalis (Western clawed frog) la vectensis (Starlet sea anemone) ARP53293_P050 Q28C11_XENTR Trafficking protein particle complex 5 (Silurana tropicalis) 188 100.00% RGS17 ARP34053_T100 Q6DDG9_XENLA Rgs20‐prov protein Xenopus laevis (African clawed frog) 253 84.00% Xenopus tropicalis (Western clawed frog) RGS17 ARP34053_T100 B2GUL9_XENTR LOC100158614 protein (Silurana tropicalis) 218 84.00% ORF Names:CpipJ_CPIJ008086 EMBL EDS30108.1OrganismCulex quinquefasciatus (Southern house mosquito) (Culex pungens) ARP46241_P050 Q6PF41_XENLA MGC68961 protein Xenopus laevis (African clawed frog) 628 100.00% ORF Names:CpipJ_CPIJ008086 EMBL EDS30108.1OrganismCulex quinquefasciatus (Southern house mosquito) (Culex pungens) ARP46241_P050 Q6NTV3_XENLA MGC81512 protein Xenopus laevis (African clawed frog) 635 100.00% ORF Names:CpipJ_CPIJ008086 EMBL EDS30108.1OrganismCulex quinquefasciatus (Southern house Xenopus tropicalis (Western clawed frog) mosquito) (Culex pungens) ARP46241_P050 Q6GL09_XENTR WW domain binding protein 11 (Silurana tropicalis) 636 100.00% ORF Names:CpipJ_CPIJ008086 EMBL EDS30108.1OrganismCulex quinquefasciatus (Southern house Xenopus tropicalis (Western clawed frog) mosquito) (Culex pungens) ARP46241_P050 Q28DY0_XENTR WW domain binding protein 11 (Silurana tropicalis) 636 100.00%

ORF Names:v1g98586OrganismNematostell a vectensis (Starlet sea anemone) ARP36483_P050 Q6NU50_XENLA MGC81247 protein Xenopus laevis (African clawed frog) 679 92.00% ORF Names:M23134_00153 EMBL EAY28999.1OrganismMicroscilla marina Acetyl‐CoA acetyltransferase, mitochondrial Xenopus tropicalis (Western clawed frog) ATCC 23134 ARP54278_P050 THIL_XENTR (EC 2.3.1.9) (Acetoacetyl‐CoA thiolase) (Silurana tropicalis) 420 100.00% ORF Names:M23134_00153 EMBL EAY28999.1OrganismMicroscilla marina Acetyl‐CoA acetyltransferase B, mitochondrial ATCC 23134 ARP54278_P050 THILB_XENLA (EC 2.3.1.9) (Acetoacetyl‐CoA thiolase B) Xenopus laevis (African clawed frog) 420 100.00% ORF Names:M23134_00153 EMBL EAY28999.1OrganismMicroscilla marina Acetyl‐CoA acetyltransferase A, mitochondrial ATCC 23134 ARP54278_P050 THILA_XENLA (EC 2.3.1.9) (Acetoacetyl‐CoA thiolase A) Xenopus laevis (African clawed frog) 420 100.00% Gamma‐aminobutyric acid receptor‐ associated protein‐like 1 (GABA(A) receptor‐ Xenopus tropicalis (Western clawed frog) ARP55398_P050 GBRL1_XENTR associated protein‐like 1) (Silurana tropicalis) 117 100.00% Gamma‐aminobutyric acid receptor‐ associated protein‐like 1 (GABA(A) receptor‐ ARP55398_P050 GBRL1_XENLA associated protein‐like 1) Xenopus laevis (African clawed frog) 117 100.00% Xenopus tropicalis (Western clawed frog) UPP1 ARP42125_P050 Q640U6_XENTR Upp2 protein (Silurana tropicalis) 316 81.00% UPP1 ARP42125_P050 Q5HZS4_XENLA LOC496317 protein Xenopus laevis (African clawed frog) 316 81.00%

Glutamyl‐tRNA(Gln) amidotransferase subunit A homolog (EC 6.3.5.‐) (Glutaminyl‐tRNA Xenopus tropicalis (Western clawed frog) ARP42512_P050 QRSL1_XENTR synthase‐like protein 1) (Silurana tropicalis) 524 84.00% Glutamyl‐tRNA(Gln) amidotransferase subunit A homolog (EC 6.3.5.‐) (Glutaminyl‐tRNA ARP42512_P050 QRSL1_XENLA synthase‐like protein 1) Xenopus laevis (African clawed frog) 524 76.00% Xenopus tropicalis (Western clawed frog) cdc5l ARP40347_P050 Q66JL3_XENTR CDC5 cell division cycle 5‐like (Silurana tropicalis) 804 85.00% cdc5l ARP40347_P050 Q4V858_XENLA Cdc5l protein Xenopus laevis (African clawed frog) 804 85.00% cdc5l ARP40347_P050 A1A5J6_XENLA LOC443636 protein Xenopus laevis (African clawed frog) 804 85.00% Clic4 ARP35222_T100 Q6DFA4_XENLA MGC83873 protein Xenopus laevis (African clawed frog) 252 76.00% Xenopus tropicalis (Western clawed frog) Hdac2 ARP31931_P050 Q6GLI1_XENTR (Silurana tropicalis) 488 84.00% Hdac2 ARP31931_P050 Q66J55_XENLA Hdac2 protein Xenopus laevis (African clawed frog) 488 84.00% Xenopus tropicalis (Western clawed frog) Hdac2 ARP31931_P050 Q28CG8_XENTR Histone deacetylase 2 (Silurana tropicalis) 488 84.00% LOC100036998 ARP55927_P050 A1L3G3_XENLA LOC100036998 protein (Fragment) Xenopus laevis (African clawed frog) 472 85.00% LOC100036998 ARP55927_P050 A9UMN9_XENLA LOC100137693 protein Xenopus laevis (African clawed frog) 406 78.00% ANAPC7 ARP41605_P050 Q6DDX5_XENLA Anapc7‐prov protein Xenopus laevis (African clawed frog) 565 100.00% ANAPC7 ARP41605_P050 Q641E4_XENLA MGC81861 protein Xenopus laevis (African clawed frog) 565 100.00%

Anaphase promoting complex subunit 7 Xenopus tropicalis (Western clawed frog) ANAPC7 ARP41605_P050 Q28GD7_XENTR (Putative uncharacterized protein LOC549081) (Silurana tropicalis) 565 100.00% Xenopus tropicalis (Western clawed frog) ARP42081_T100 B5DDV7_XENTR Putative uncharacterized protein (Silurana tropicalis) 136 85.00% ARP42081_T100 Q6NU58_XENLA MGC81232 protein Xenopus laevis (African clawed frog) 136 84.00% ARP41163_P050 Q5XGY4_XENLA LOC495256 protein (Fragment) Xenopus laevis (African clawed frog) 615 100.00% Novel protein containing Surp module and G‐ Xenopus tropicalis (Western clawed frog) ARP41163_P050 Q28E21_XENTR patch domain (Silurana tropicalis) 617 100.00% Xenopus tropicalis (Western clawed frog) ARP41163_P050 B1WB15_XENTR Splicing factor 4 (Silurana tropicalis) 617 100.00% ORF Names:LinJ19.1300 EMBL CAM67351.1OrganismLeishmania infantum ARP42146_T100 Q6GP13_XENLA MGC80748 protein Xenopus laevis (African clawed frog) 284 100.00% ORF Names:LinJ19.1300 EMBL CAM67351.1OrganismLeishmania infantum ARP42146_T100 Q4V803_XENLA MGC114881 protein Xenopus laevis (African clawed frog) 283 100.00% ORF Names:LinJ19.1300 EMBL CAM67351.1OrganismLeishmania Xenopus tropicalis (Western clawed frog) infantum ARP42146_T100 Q5XGH7_XENTR Phosphatidic acid phosphatase 2a (Silurana tropicalis) 283 92.00% ORF Names:LinJ19.1300 EMBL CAM67351.1OrganismLeishmania Xenopus tropicalis (Western clawed frog) infantum ARP42146_T100 B0BM26_XENTR Ppap2a protein (Silurana tropicalis) 284 92.00% ORF Names:LinJ19.1300 EMBL CAM67351.1OrganismLeishmania Xenopus tropicalis (Western clawed frog) infantum ARP42146_T100 Q6P897_XENTR Phosphatidic acid phosphatase type 2C (Silurana tropicalis) 283 100.00% ORF Names:LinJ19.1300 EMBL CAM67351.1OrganismLeishmania infantum ARP42146_T100 Q6GR33_XENLA MGC81169 protein Xenopus laevis (African clawed frog) 257 100.00% ORF Names:LinJ19.1300 EMBL CAM67351.1OrganismLeishmania infantum ARP42146_T100 Q6GN60_XENLA LOC443680 protein (Fragment) Xenopus laevis (African clawed frog) 274 100.00% Polypeptide N‐ Xenopus tropicalis (Western clawed frog) GALNT4 ARP45527_P050 Q08CX0_XENTR acetylgalactosaminyltransferase 4 (Silurana tropicalis) 582 92.00% GALNT4 ARP45527_P050 Q6IR91_XENLA MGC81150 protein Xenopus laevis (African clawed frog) 582 85.00%

Transducin‐like enhancer of split 4 homolog of Xenopus tropicalis (Western clawed frog) TLE4 ARP32381_P050 Q07G19_XENTR Drosophila E(Spl) (Fragment) (Silurana tropicalis) 398 92.00% Xenopus tropicalis (Western clawed frog) TLE4 ARP32381_P050 D2JPI7_XENTR TLE4 (Silurana tropicalis) 772 92.00%

Transducin‐like enhancer protein 4 (Enhancer of split groucho‐like protein 2) (ESG2) (xESG2) TLE4 ARP32381_P050 TLE4_XENLA (Grg‐4) (XGrg‐4) (Groucho‐related protein 4) Xenopus laevis (African clawed frog) 772 92.00% IMPA1 ARP58713_P050 Q7SYT9_XENLA Impa1‐prov protein Xenopus laevis (African clawed frog) 280 75.00% IMPA1 ARP58713_P050 Q6GM60_XENLA MGC83403 protein Xenopus laevis (African clawed frog) 280 75.00%

Inositol(Myo)‐1(Or 4)‐monophosphatase 1 Xenopus tropicalis (Western clawed frog) IMPA1 ARP58713_P050 Q28FW1_XENTR (Putative uncharacterized protein LOC549811) (Silurana tropicalis) 280 75.00% IMPA1 ARP58713_P050 B7ZRY8_XENLA MGC83403 protein Xenopus laevis (African clawed frog) 280 75.00% Inositol monophosphatase 1 (IMP 1) (IMPase 1) (EC 3.1.3.25) (Inositol‐1(or 4)‐ IMPA1 ARP58713_P050 IMPA1_XENLA monophosphatase 1) Xenopus laevis (African clawed frog) 285 75.00% Mrpl39 ARP46256_P050 Q4QR02_XENLA LOC733275 protein (Fragment) Xenopus laevis (African clawed frog) 300 78.00% Xenopus tropicalis (Western clawed frog) Mrpl39 ARP46256_P050 Q5M7P1_XENTR Mitochondrial ribosomal protein L39 (Silurana tropicalis) 331 78.00% Xenopus tropicalis (Western clawed frog) Mrpl39 ARP46256_P050 Q28FF7_XENTR Mitochondrial ribosomal protein L39 (Silurana tropicalis) 352 78.00%

ORF Names:37129OrganismMonosiga Xenopus tropicalis (Western clawed frog) brevicollis (Choanoflagellate) ARP40759_T100 B0BMQ2_XENTR LOC100145091 protein (Silurana tropicalis) 507 85.00% ORF Names:NFIA_067690 EMBL EAW21602.1OrganismNeosartorya fischeri (strain ATCC 1020 / DSM 3700 / FGSC A1164 / NRRL 181) (Aspergillus fischerianus) ARP40552_P050 Q7ZWY7_XENLA Scye1‐prov protein Xenopus laevis (African clawed frog) 297 92.00% Nuclear receptor subfamily 2 group C member 1 (Developmental orphan receptor 2) (DOR2) (Orphan nuclear receptor TR2) (Testicular Xenopus tropicalis (Western clawed frog) ARP38288_P050 NR2C1_XENTR receptor 2) (Silurana tropicalis) 636 90.00%

Nuclear receptor subfamily 2 group C member 1‐B (Developmental orphan receptor 2‐B) (DOR2‐B) (xDOR2‐B) (Orphan nuclear receptor ARP38288_P050 N2C1B_XENLA TR2‐B) (Testicular receptor 2‐B) Xenopus laevis (African clawed frog) 637 90.00%

Nuclear receptor subfamily 2 group C member 1‐A (Developmental orphan receptor 2‐A) (DOR2‐A) (xDOR2‐A) (Orphan nuclear receptor ARP38288_P050 N2C1A_XENLA TR2‐A) (Testicular receptor 2‐A) Xenopus laevis (African clawed frog) 637 90.00% atp2b1a ARP44391_P050 Q6DCT8_XENLA Atp2b3‐prov protein Xenopus laevis (African clawed frog) 1208 100.00% Xenopus tropicalis (Western clawed frog) atp2b1a ARP44391_P050 B4F6S6_XENTR LOC100125191 protein (Silurana tropicalis) 1157 100.00% Xenopus tropicalis (Western clawed frog) atp2b1a ARP44391_P050 A4QNQ9_XENTR LOC100125191 protein (Fragment) (Silurana tropicalis) 335 100.00% atp2b1a ARP44391_P050 B3VIA2_XENLA Plasma membrane calcium ATPase 1b Xenopus laevis (African clawed frog) 1214 92.00% hmgb2l ARP38110_T100 Q91764_XENLA HMG‐X protein Xenopus laevis (African clawed frog) 212 92.00% hmgb2l ARP38110_T100 Q91596_XENLA High mobility group protein‐1 Xenopus laevis (African clawed frog) 210 92.00% hmgb2l ARP38110_T100 Q8AVU3_XENLA MGC52825 protein Xenopus laevis (African clawed frog) 212 92.00% hmgb2l ARP38110_T100 Q7ZXK5_XENLA MGC52578 protein Xenopus laevis (African clawed frog) 212 92.00% hmgb2l ARP38110_T100 Q7SZ42_XENLA Hmgb1‐prov protein Xenopus laevis (African clawed frog) 211 92.00% Xenopus tropicalis (Western clawed frog) hmgb2l ARP38110_T100 Q6P4N5_XENTR High‐mobility group box 1 (Silurana tropicalis) 211 92.00% hmgb2l ARP38110_T100 Q6GNQ5_XENLA HMG‐1 protein Xenopus laevis (African clawed frog) 210 92.00% hmgb2l ARP38110_T100 Q32NS7_XENLA MGC52825 protein Xenopus laevis (African clawed frog) 211 92.00% Xenopus tropicalis (Western clawed frog) hmgb2l ARP38110_T100 Q6P7M9_XENTR High‐mobility group box 2 (Silurana tropicalis) 212 85.00% Xenopus tropicalis (Western clawed frog) hmgb2l ARP38110_T100 B5DE56_XENTR Putative uncharacterized protein (Silurana tropicalis) 214 83.00% wnt8b ARP33491_T100 B7ZQM6_XENLA Xwnt‐8b protein Xenopus laevis (African clawed frog) 428 91.00% wnt8b ARP33491_T100 WNT8B_XENLA Isoform Short Xenopus laevis (African clawed frog) 355 91.00% wnt8b ARP33491_T100 WNT8B_XENLA Protein Wnt‐8b (XWnt‐8b) Xenopus laevis (African clawed frog) 428 91.00% ORF Names:OSTLU_93472 EMBL ABO98816.1OrganismOstreococcus lucimarinus (strain CCE9901) ARP34207_P050 Q6DE48_XENLA Rbbp5‐prov protein Xenopus laevis (African clawed frog) 501 100.00% ORF Names:OSTLU_93472 EMBL ABO98816.1OrganismOstreococcus Xenopus tropicalis (Western clawed frog) lucimarinus (strain CCE9901) ARP34207_P050 Q566L3_XENTR Retinoblastoma binding protein 5 (Silurana tropicalis) 501 100.00% Xenopus tropicalis (Western clawed frog) ARP53078_P050 Q5M7L7_XENTR LOC496853 protein (Silurana tropicalis) 365 92.00% Xenopus tropicalis (Western clawed frog) ARP53078_P050 Q28DN3_XENTR Novel protein (Silurana tropicalis) 365 92.00% Xenopus tropicalis (Western clawed frog) PDSS1 ARP46195_T100 Q0VFI8_XENTR Trans‐prenyltransferase (Silurana tropicalis) 292 85.00% Xenopus tropicalis (Western clawed frog) NOL6 ARP40994_P050 NOL6_XENTR Nucleolar protein 6 (Silurana tropicalis) 1145 78.00% NOL6 ARP40994_P050 NOL6_XENLA Nucleolar protein 6 Xenopus laevis (African clawed frog) 1147 78.00% Xenopus tropicalis (Western clawed frog) fam76b ARP52727_P050 FA76B_XENTR Protein FAM76B (Silurana tropicalis) 337 92.00% fam76b ARP52727_P050 FA76B_XENLA Protein FAM76B Xenopus laevis (African clawed frog) 337 92.00% Xenopus tropicalis (Western clawed frog) DVL1 ARP32100_T100 B1H321_XENTR Dvl1 protein (Silurana tropicalis) 559 93.00%

Segment polarity protein dishevelled homolog Xenopus tropicalis (Western clawed frog) DVL1 ARP32100_T100 DVL3_XENTR DVL‐3 (Dishevelled‐3) (DSH homolog 3) (Silurana tropicalis) 713 85.00%

Segment polarity protein dishevelled homolog DVL1 ARP32100_T100 DVL3_XENLA DVL‐3 (Dishevelled‐3) (DSH homolog 3) Xenopus laevis (African clawed frog) 717 85.00% DVL1 ARP32100_T100 Q5EAW6_XENLA Xdsh protein Xenopus laevis (African clawed frog) 673 78.00%

Segment polarity protein dishevelled homolog Xenopus tropicalis (Western clawed frog) DVL1 ARP32100_T100 DVL2_XENTR DVL‐2 (Dishevelled‐2) (DSH homolog 2) (Silurana tropicalis) 732 78.00%

Segment polarity protein dishevelled homolog DVL1 ARP32100_T100 DVL2_XENLA DVL‐2 (Dishevelled‐2) (DSH homolog 2) (Xdsh) Xenopus laevis (African clawed frog) 736 78.00% ORF Names:CpipJ_CPIJ008898 EMBL EDS32121.1OrganismCulex quinquefasciatus (Southern house mosquito) (Culex pungens) ARP52043_P050 Q5EAV0_XENLA MGC85146 protein Xenopus laevis (African clawed frog) 424 100.00% ORF Names:CpipJ_CPIJ008898 EMBL EDS32121.1OrganismCulex quinquefasciatus (Southern house Xenopus tropicalis (Western clawed frog) mosquito) (Culex pungens) ARP52043_P050 B6ID06_XENTR Putative uncharacterized protein (Silurana tropicalis) 416 100.00% ORF Names:CpipJ_CPIJ008898 EMBL EDS32121.1OrganismCulex quinquefasciatus (Southern house Xenopus tropicalis (Western clawed frog) mosquito) (Culex pungens) ARP52043_P050 B4F6S2_XENTR Putative uncharacterized protein (Silurana tropicalis) 410 100.00% ORF Names:CpipJ_CPIJ008898 EMBL EDS32121.1OrganismCulex quinquefasciatus (Southern house mosquito) (Culex pungens) ARP52043_P050 A1L1H1_XENLA LOC100036840 protein Xenopus laevis (African clawed frog) 424 92.00% ORF Names:CpipJ_CPIJ008898 EMBL EDS32121.1OrganismCulex quinquefasciatus (Southern house Xenopus tropicalis (Western clawed frog) mosquito) (Culex pungens) ARP52043_P050 Q5FW24_XENTR Casein kinase 1, gamma 2 (Silurana tropicalis) 375 92.00% ORF Names:CpipJ_CPIJ008898 EMBL EDS32121.1OrganismCulex quinquefasciatus (Southern house Xenopus tropicalis (Western clawed frog) mosquito) (Culex pungens) ARP52043_P050 Q6GL54_XENTR Casein kinase 1, gamma 1 (Silurana tropicalis) 451 92.00% ORF Names:CpipJ_CPIJ008898 EMBL EDS32121.1OrganismCulex quinquefasciatus (Southern house Xenopus tropicalis (Western clawed frog) mosquito) (Culex pungens) ARP52043_P050 Q3LS18_XENTR Casein kinase 1 gamma 2 (Silurana tropicalis) 460 92.00% ORF Names:CpipJ_CPIJ008898 EMBL EDS32121.1OrganismCulex quinquefasciatus (Southern house Casein kinase I isoform gamma‐1 (CKI‐gamma mosquito) (Culex pungens) ARP52043_P050 KC1G1_XENLA 1) (EC 2.7.11.1) Xenopus laevis (African clawed frog) 460 92.00% ORF Names:CpipJ_CPIJ008898 EMBL EDS32121.1OrganismCulex quinquefasciatus (Southern house mosquito) (Culex pungens) ARP52043_P050 Q6GN14_XENLA MGC83646 protein Xenopus laevis (African clawed frog) 412 85.00% ORF Names:OSTLU_34867 EMBL ABO98021.1OrganismOstreococcus Xenopus tropicalis (Western clawed frog) lucimarinus (strain CCE9901) ARP46289_T100 Q28DV4_XENTR Novel protein (Silurana tropicalis) 649 100.00% ORF Names:OSTLU_34867 EMBL ABO98021.1OrganismOstreococcus lucimarinus (strain CCE9901) ARP46289_T100 Q498E9_XENLA MGC115581 protein Xenopus laevis (African clawed frog) 653 92.00% ORF Names:NFIA_105530 EMBL EAW25065.1OrganismNeosartorya fischeri (strain ATCC 1020 / DSM 3700 / FGSC A1164 / NRRL 181) (Aspergillus fischerianus) ARP57743_P050 Q8AVD2_XENLA Psma3‐prov protein Xenopus laevis (African clawed frog) 255 85.00% ORF Names:NFIA_105530 EMBL EAW25065.1OrganismNeosartorya fischeri (strain ATCC 1020 / DSM 3700 / Proteasome (Prosome macropain) subunit FGSC A1164 / NRRL 181) (Aspergillus alpha type 3 (Proteasome (Prosome, Xenopus tropicalis (Western clawed frog) fischerianus) ARP57743_P050 Q5PPP6_XENTR macropain) subunit, alpha type, 3) (Silurana tropicalis) 255 85.00% ORF Names:NFIA_105530 EMBL EAW25065.1OrganismNeosartorya fischeri (strain ATCC 1020 / DSM 3700 / FGSC A1164 / NRRL 181) (Aspergillus Proteasome subunit alpha type 3 alpha fischerianus) ARP57743_P050 B2L4K8_XENBO (Fragment) Xenopus borealis (Kenyan clawed frog) 38 85.00% ORF Names:NFIA_105530 EMBL EAW25065.1OrganismNeosartorya fischeri (strain ATCC 1020 / DSM 3700 / FGSC A1164 / NRRL 181) (Aspergillus fischerianus) ARP57743_P050 Q6PE96_XENLA MGC68557 protein Xenopus laevis (African clawed frog) 255 78.00% ORF Names:NFIA_105530 EMBL EAW25065.1OrganismNeosartorya fischeri (strain ATCC 1020 / DSM 3700 / FGSC A1164 / NRRL 181) (Aspergillus Xenopus tropicalis (Western clawed frog) fischerianus) ARP57743_P050 A9UMF5_XENTR LOC100135338 protein (Silurana tropicalis) 138 78.00% Srp68 ARP40757_P050 A6H8I5_XENLA LOC100101323 protein Xenopus laevis (African clawed frog) 600 92.00% Xenopus tropicalis (Western clawed frog) Srp68 ARP40757_P050 B1H2B5_XENTR LOC100145378 protein (Silurana tropicalis) 593 85.00%

ORF Names:BRAFLDRAFT_104157 EMBL EEN69721.1OrganismBranchiostoma Xenopus tropicalis (Western clawed frog) floridae (Florida lancelet) (Amphioxus) ARP55475_P050 Q5M7L7_XENTR LOC496853 protein (Silurana tropicalis) 365 84.00%

ORF Names:BRAFLDRAFT_104157 EMBL EEN69721.1OrganismBranchiostoma Xenopus tropicalis (Western clawed frog) floridae (Florida lancelet) (Amphioxus) ARP55475_P050 Q28DN3_XENTR Novel protein (Silurana tropicalis) 365 84.00% map1lc3a ARP51335_P050 Q7ZY72_XENLA Map1lc3a‐prov protein Xenopus laevis (African clawed frog) 121 75.00% map1lc3a ARP51335_P050 Q7T0T4_XENLA MGC69006 protein Xenopus laevis (African clawed frog) 121 75.00% Map1lc3a protein (Microtubule‐associated Xenopus tropicalis (Western clawed frog) map1lc3a ARP51335_P050 Q66KA4_XENTR protein 1 light chain 3 alpha) (Silurana tropicalis) 121 75.00% ORF Names:GSPATT00001816001 EMBL CAK78775.1OrganismParamecium Xenopus tropicalis (Western clawed frog) tetraurelia ARP53199_P050 B7ZTT1_XENTR Tubulin tyrosine ligase (Silurana tropicalis) 377 85.00% ORF Names:GSPATT00001816001 EMBL CAK78775.1OrganismParamecium Xenopus tropicalis (Western clawed frog) tetraurelia ARP53199_P050 A9ULH4_XENTR Ttl protein (Silurana tropicalis) 377 85.00% Myeloid differentiation primary response Xenopus tropicalis (Western clawed frog) ARP56353_P050 MYD88_XENTR protein MyD88 (Silurana tropicalis) 283 78.00% Myeloid differentiation primary response protein MyD88‐B (Toll/IL‐1 receptor binding ARP56353_P050 MY88B_XENLA protein MyD88‐B) Xenopus laevis (African clawed frog) 283 78.00% Myeloid differentiation primary response protein MyD88‐A (Toll/IL‐1 receptor binding ARP56353_P050 MY88A_XENLA protein MyD88‐A) Xenopus laevis (African clawed frog) 283 78.00% Phosphoinositide‐3‐kinase, catalytic, beta Xenopus tropicalis (Western clawed frog) Pik3cb ARP32117_T100 Q0IHS8_XENTR polypeptide (Silurana tropicalis) 1065 92.00%

TAF4 RNA polymerase II, TATA box binding Xenopus tropicalis (Western clawed frog) Taf4a ARP33394_P050 Q0IJ02_XENTR protein (TBP)‐associated factor, 135kDa (Silurana tropicalis) 1033 100.00% Taf4a ARP33394_P050 A2BD93_XENLA LOC100037075 protein Xenopus laevis (African clawed frog) 1016 92.00% SEC63 ARP46839_T100 Q2TAH5_XENLA LOC495416 protein Xenopus laevis (African clawed frog) 754 92.00% SEC63 ARP46839_T100 Q6GQC5_XENLA MGC80164 protein Xenopus laevis (African clawed frog) 755 85.00% Fructose‐1,6‐bisphosphatase (EC 3.1.3.11) fbp2 ARP47813_P050 Q9I8B1_XENLA (Fragment) Xenopus laevis (African clawed frog) 122 92.00% fbp2 ARP47813_P050 Q7SZA0_XENLA Fbp‐prov protein Xenopus laevis (African clawed frog) 338 92.00% Xenopus tropicalis (Western clawed frog) fbp2 ARP47813_P050 Q6P8F7_XENTR Fructose‐1,6‐bisphosphatase (Silurana tropicalis) 338 92.00% Xenopus tropicalis (Western clawed frog) fbp2 ARP47813_P050 Q501L0_XENTR Putative uncharacterized protein mgc108013 (Silurana tropicalis) 339 78.00% Ordered Locus Names:Arth_1617OrganismArthrobacte r sp. (strain FB24) ARP32298_P050 Q6PAW6_XENLA MGC68638 protein Xenopus laevis (African clawed frog) 675 100.00% Ordered Locus Names:Arth_1617OrganismArthrobacte Xenopus tropicalis (Western clawed frog) r sp. (strain FB24) ARP32298_P050 Q6DJ53_XENTR Sex comb on midleg homolog 1 (Silurana tropicalis) 675 100.00% Ordered Locus Names:Arth_1617OrganismArthrobacte r sp. (strain FB24) ARP32298_P050 Q6AX63_XENLA MGC84069 protein Xenopus laevis (African clawed frog) 602 100.00% Xenopus tropicalis (Western clawed frog) Coro1b ARP38899_T100 B1H1C2_XENTR Putative uncharacterized protein (Silurana tropicalis) 471 85.00% Coro1b ARP38899_T100 Q6P9I1_XENLA MGC69077 protein Xenopus laevis (African clawed frog) 462 85.00% Xenopus tropicalis (Western clawed frog) Coro1b ARP38899_T100 Q6DJ14_XENTR Coronin, actin binding protein, 2B (Silurana tropicalis) 459 85.00% Coro1b ARP38899_T100 Q9PWG7_XENLA Coro1c protein (Coronin homolog) Xenopus laevis (African clawed frog) 480 78.00% Coro1b ARP38899_T100 Q9PWG8_XENLA Coronin homolog (MGC52538 protein) Xenopus laevis (African clawed frog) 480 78.00% Xenopus tropicalis (Western clawed frog) Coro1b ARP38899_T100 Q6P1T9_XENTR Coronin, actin binding protein 1C (Silurana tropicalis) 480 78.00% Xenopus tropicalis (Western clawed frog) myol ARP52859_P050 MTPN_XENTR Myotrophin (Silurana tropicalis) 118 78.00% myol ARP52859_P050 MTPN_XENLA Myotrophin Xenopus laevis (African clawed frog) 118 78.00% LOC100037183 ARP41458_P050 B1H1M9_XENLA LOC100037183 protein (Fragment) Xenopus laevis (African clawed frog) 530 100.00% LOC100135191 protein (Putative Xenopus tropicalis (Western clawed frog) LOC100037183 ARP41458_P050 A9ULE5_XENTR uncharacterized protein LOC100135191) (Silurana tropicalis) 531 100.00% LOC100037183 ARP41458_P050 A2VD80_XENLA LOC100037183 protein (Fragment) Xenopus laevis (African clawed frog) 525 100.00% Xenopus tropicalis (Western clawed frog) LOC100037183 ARP41458_P050 Q6DJ94_XENTR UGT2B11 protein (Fragment) (Silurana tropicalis) 529 78.00% Xenopus tropicalis (Western clawed frog) rorb ARP45606_T100 Q08D40_XENTR RAR‐related orphan receptor A (Silurana tropicalis) 267 100.00% CG18418 ARP43850_P050 Q6INH3_XENLA MGC82600 protein Xenopus laevis (African clawed frog) 305 100.00% Xenopus tropicalis (Western clawed frog) CG18418 ARP43850_P050 Q566L1_XENTR MGC97830 protein (Silurana tropicalis) 305 100.00% CG18418 ARP43850_P050 Q0IH35_XENLA MGC154791 protein Xenopus laevis (African clawed frog) 305 100.00% Xenopus tropicalis (Western clawed frog) ARP41933_P050 Q0V9W2_XENTR Collapsin response mediator protein 1 (Silurana tropicalis) 680 92.00% Dihydropyrimidinase‐related protein 3 (DRP‐ Xenopus tropicalis (Western clawed frog) ARP41933_P050 DPYL3_XENTR 3) (Dihydropyrimidinase‐like 3) (Silurana tropicalis) 571 85.00% Dihydropyrimidinase‐related protein 3‐B (DRP‐ 3‐B) (Collapsin response mediator protein 4) ARP41933_P050 DPY3B_XENLA (CRMP‐4) (xCRMP4) Xenopus laevis (African clawed frog) 571 85.00% Dihydropyrimidinase‐related protein 3‐A (DRP‐ ARP41933_P050 DPY3A_XENLA 3‐A) (Neural‐specific protein 1) Xenopus laevis (African clawed frog) 571 85.00% ARP41933_P050 Q566H1_XENLA MGC115310 protein Xenopus laevis (African clawed frog) 612 85.00%

ORF Names:v1g88355OrganismNematostell a vectensis (Starlet sea anemone) ARP33754_T100 Q2NLA7_XENLA PARP protein Xenopus laevis (African clawed frog) 1011 91.00%

Poly [ADP‐ribose] polymerase 1 (PARP‐1) (EC ORF 2.4.2.30) (NAD(+) ADP‐ribosyltransferase 1) Names:v1g88355OrganismNematostell (ADPRT 1) (Poly[ADP‐ribose] synthase 1) a vectensis (Starlet sea anemone) ARP33754_T100 PARP1_XENLA (Fragment) Xenopus laevis (African clawed frog) 998 91.00%

DNA replication licensing factor mcm4 Xenopus tropicalis (Western clawed frog) MCM4 ARP36663_T100 MCM4_XENTR (Minichromosome maintenance protein 4) (Silurana tropicalis) 863 100.00% DNA replication licensing factor mcm4‐B (CDC21 homolog‐B) (Minichromosome maintenance protein 4‐B) (xMCM4‐B) (P1‐ MCM4 ARP36663_T100 MCM4B_XENLA CDC21‐B) Xenopus laevis (African clawed frog) 863 100.00% Minichromosome maintenance deficient 4 MCM4 ARP36663_T100 B2L4G0_XENBO (Fragment) Xenopus borealis (Kenyan clawed frog) 32 100.00% DNA replication licensing factor mcm4‐A (CDC21 homolog‐A) (Minichromosome maintenance protein 4‐A) (xMCM4‐A) (P1‐ MCM4 ARP36663_T100 MCM4A_XENLA CDC21‐A) (p98) Xenopus laevis (African clawed frog) 858 92.00%

ORF Names:TRIADDRAFT_35221 EMBL EDV29401.1OrganismTrichoplax adhaerens (Trichoplax reptans) ARP54788_P050 Q640H5_XENLA Isocitrate dehydrogenase [NADP] (EC 1.1.1.42) Xenopus laevis (African clawed frog) 415 85.00% Xenopus tropicalis (Western clawed frog) LOC733956 ARP39178_T100 Q28C24_XENTR REST corepressor 1 (Silurana tropicalis) 432 92.00% Xenopus tropicalis (Western clawed frog) LOC733956 ARP39178_T100 B1H1F2_XENTR LOC733956 protein (Silurana tropicalis) 434 92.00% LOC733956 ARP39178_T100 Q5FWQ2_XENLA Rcor1 protein Xenopus laevis (African clawed frog) 225 85.00% REST corepressor 1 (Protein CoREST) LOC733956 ARP39178_T100 RCOR1_XENLA (xCoREST) Xenopus laevis (African clawed frog) 431 85.00% Xenopus tropicalis (Western clawed frog) rpS16 ARP33535_T100 Q5XGA8_XENTR Ribosomal protein S16 (Silurana tropicalis) 146 100.00% rpS16 ARP33535_T100 Q3KQC9_XENLA Rps16 protein Xenopus laevis (African clawed frog) 146 100.00% Vim ARP48225_P050 Q7ZXC6_XENLA Vim1 protein Xenopus laevis (African clawed frog) 458 78.00% Vim ARP48225_P050 Q7ZX54_XENLA Vim4 protein Xenopus laevis (African clawed frog) 463 78.00% Vim ARP48225_P050 Q7SZ33_XENLA Vim4 protein Xenopus laevis (African clawed frog) 463 78.00% Xenopus tropicalis (Western clawed frog) Vim ARP48225_P050 Q5M8K3_XENTR Vim protein (Fragment) (Silurana tropicalis) 485 78.00% Xenopus tropicalis (Western clawed frog) Vim ARP48225_P050 B5DES2_XENTR Vim protein (Silurana tropicalis) 461 78.00% Xenopus tropicalis (Western clawed frog) Vim ARP48225_P050 A4IGY5_XENTR Vim protein (Fragment) (Silurana tropicalis) 484 78.00% Vim ARP48225_P050 VIM4_XENLA Vimentin‐4 Xenopus laevis (African clawed frog) 463 78.00% Vim ARP48225_P050 VIM1_XENLA Vimentin‐1/2 Xenopus laevis (African clawed frog) 458 78.00% Xenopus tropicalis (Western clawed frog) pdxk ARP53615_P050 A0JLY9_XENTR Putative uncharacterized protein MGC145124 (Silurana tropicalis) 316 85.00% ARP56372_P050 Q1PPZ9_XENLA Ornithine decarboxylase antizyme 2 Xenopus laevis (African clawed frog) 186 78.00% Xenopus tropicalis (Western clawed frog) ARP56372_P050 A9JTM5_XENTR LOC100127795 protein (Silurana tropicalis) 94 78.00% ssbp3 ARP39711_P050 Q7ZX94_XENLA MGC53880 protein Xenopus laevis (African clawed frog) 387 92.00% ssbp3 ARP39711_P050 Q801Q3_XENLA Ssbp3‐prov protein Xenopus laevis (African clawed frog) 391 92.00% Xenopus tropicalis (Western clawed frog) ssbp3 ARP39711_P050 Q6P4M2_XENTR Single stranded DNA binding protein 3 (Silurana tropicalis) 392 92.00% Xenopus tropicalis (Western clawed frog) ssbp3 ARP39711_P050 Q28CH5_XENTR Single stranded DNA binding protein 3 (Silurana tropicalis) 358 92.00% Xenopus tropicalis (Western clawed frog) ssbp3 ARP39711_P050 B4F6Z1_XENTR Ssbp3 protein (Silurana tropicalis) 391 92.00% Xenopus tropicalis (Western clawed frog) ssbp3 ARP39711_P050 A0JLY6_XENTR Ssbp3 protein (Silurana tropicalis) 396 92.00% ssbp3 ARP39711_P050 Q7ZYQ7_XENLA Ssbp2‐prov protein Xenopus laevis (African clawed frog) 359 78.00% ssbp3 ARP39711_P050 Q6NRV5_XENLA Ssbp2‐prov protein Xenopus laevis (African clawed frog) 387 78.00% Xenopus tropicalis (Western clawed frog) ssbp3 ARP39711_P050 B4F6X9_XENTR Putative uncharacterized protein (Silurana tropicalis) 387 78.00% Seryl‐aminoacyl‐tRNA synthetase 1 (Seryl‐ Xenopus tropicalis (Western clawed frog) Sars ARP40655_T100 Q6NVT3_XENTR tRNA synthetase) (Silurana tropicalis) 511 92.00% Sars ARP40655_T100 Q7ZY49_XENLA Sars‐prov protein Xenopus laevis (African clawed frog) 510 85.00% Xenopus tropicalis (Western clawed frog) SSRP1 ARP38249_P050 Q6GLF4_XENTR Ssrp1 protein (Fragment) (Silurana tropicalis) 629 100.00% SSRP1 ARP38249_P050 Q4KLX2_XENLA MGC114656 protein Xenopus laevis (African clawed frog) 365 100.00%

FACT complex subunit SSRP1 (DNA unwinding factor 87 kDa subunit) (DUF87) (Facilitates chromatin transcription complex subunit ssrp1) (Structure‐specific recognition protein SSRP1 ARP38249_P050 SSRP1_XENLA 1) Xenopus laevis (African clawed frog) 693 100.00% P100639_T100 Q6AXA4_XENLA MGC80305 protein Xenopus laevis (African clawed frog) 368 91.00% V‐fos FBJ murine osteosarcoma viral Xenopus tropicalis (Western clawed frog) P100639_T100 Q28CJ5_XENTR oncogene homolog (Silurana tropicalis) 368 91.00% P100639_T100 A9UMM6_XENLA Putative uncharacterized protein Xenopus laevis (African clawed frog) 369 91.00% Xenopus tropicalis (Western clawed frog) crip2 ARP34373_P050 A0JM28_XENTR Putative uncharacterized protein MGC146056 (Silurana tropicalis) 209 85.00% Xenopus tropicalis (Western clawed frog) crip2 ARP34373_P050 Q5EB43_XENTR MGC97606 protein (Silurana tropicalis) 203 85.00% Xenopus tropicalis (Western clawed frog) crip2 ARP34373_P050 Q07G40_XENTR Cysteine‐rich protein 3 (Fragment) (Silurana tropicalis) 187 85.00% RBPMS2 ARP40268_P050 Q6PAA8_XENLA MGC68512 protein Xenopus laevis (African clawed frog) 200 100.00% RBPMS2 ARP40268_P050 Q66IX3_XENLA MGC84222 protein Xenopus laevis (African clawed frog) 197 100.00% Xenopus tropicalis (Western clawed frog) RBPMS2 ARP40268_P050 A9UME4_XENTR LOC100135328 protein (Silurana tropicalis) 199 100.00% RNA‐binding protein with multiple splicing (RBP‐MS) (Heart and RRM expressed RBPMS2 ARP40268_P050 RBPMS_XENLA sequence) (Hermes) Xenopus laevis (African clawed frog) 196 100.00% 5730494N06Rik ARP44585_P050 Q6GM26_XENLA MGC84021 protein Xenopus laevis (African clawed frog) 120 100.00% Xenopus tropicalis (Western clawed frog) 5730494N06Rik ARP44585_P050 Q6DET5_XENTR MGC89669 protein (Silurana tropicalis) 120 100.00% Xenopus tropicalis (Western clawed frog) 5730494N06Rik ARP44585_P050 Q28C04_XENTR Novel protein (Silurana tropicalis) 119 100.00% 5730494N06Rik ARP44585_P050 Q68EX6_XENLA MGC84111 protein Xenopus laevis (African clawed frog) 120 100.00% Origin recognition complex, subunit 4‐like Xenopus tropicalis (Western clawed frog) ARP57782_P050 Q6GL43_XENTR (Yeast) (Silurana tropicalis) 432 78.00% ARP57782_P050 Q3B8I2_XENLA Orc4 protein Xenopus laevis (African clawed frog) 432 78.00% ARP57782_P050 ORC4_XENLA Origin recognition complex subunit 4 Xenopus laevis (African clawed frog) 432 78.00% ARP45533_P050 Q8AVL9_XENLA MGC52827 protein Xenopus laevis (African clawed frog) 499 85.00% ARP45533_P050 Q6NU80_XENLA MGC81163 protein Xenopus laevis (African clawed frog) 498 85.00% ORF Names:PANDA_003134 EMBL EFB13677.1OrganismAiluropoda tRNA guanosine‐2'‐O‐methyltransferase melanoleuca (Giant panda) ARP48526_P050 TRM11_XENLA TRM11 homolog (EC 2.1.1.‐) Xenopus laevis (African clawed frog) 478 84.00% ARP48303_P050 Q6PAX1_XENLA MGC68615 protein Xenopus laevis (African clawed frog) 508 100.00% ARP48303_P050 Q6DEB6_XENLA Ugp2‐prov protein Xenopus laevis (African clawed frog) 497 100.00% Xenopus tropicalis (Western clawed frog) ARP48303_P050 Q68F95_XENTR Ugp2 protein (Silurana tropicalis) 508 100.00% ARP48303_P050 Q66KS0_XENLA MGC85503 protein Xenopus laevis (African clawed frog) 87 90.00% Xenopus tropicalis (Western clawed frog) PES1 ARP55008_P050 PESC_XENTR Pescadillo homolog (Silurana tropicalis) 580 85.00% PES1 ARP55008_P050 PESC_XENLA Pescadillo homolog Xenopus laevis (African clawed frog) 574 85.00% Xenopus tropicalis (Western clawed frog) hNp95 ARP34620_P050 A4IH62_XENTR LOC100124801 protein (Silurana tropicalis) 591 91.00% hNp95 ARP34620_P050 A1A5J0_XENLA Uhrf2 protein Xenopus laevis (African clawed frog) 845 91.00% hNp95 ARP34620_P050 Q6IP39_XENLA LOC432234 protein (Fragment) Xenopus laevis (African clawed frog) 597 100.00% hNp95 ARP34620_P050 Q52L17_XENLA LOC432234 protein (Fragment) Xenopus laevis (African clawed frog) 598 100.00% hNp95 ARP34620_P050 Q2TAH0_XENLA LOC432234 protein (Fragment) Xenopus laevis (African clawed frog) 656 100.00% hNp95 ARP34620_P050 B6CHA3_XENLA RING finger domain protein Np95 Xenopus laevis (African clawed frog) 772 100.00% CRYBB2 ARP52061_P050 Q7SZ91_XENLA Cryba1 protein (Cryba1‐prov protein) Xenopus laevis (African clawed frog) 214 92.00% CRYBB2 ARP52061_P050 Q640Y9_XENLA LOC494645 protein Xenopus laevis (African clawed frog) 198 92.00% Xenopus tropicalis (Western clawed frog) CRYBB2 ARP52061_P050 A4QNM6_XENTR LOC100125179 protein (Silurana tropicalis) 198 92.00% Xenopus tropicalis (Western clawed frog) CRYBB2 ARP52061_P050 B3DLR4_XENTR LOC100170535 protein (Silurana tropicalis) 198 78.00% CRYBB2 ARP52061_P050 Q6DJG8_XENLA MGC84287 protein Xenopus laevis (African clawed frog) 225 76.00% CRYBB2 ARP52061_P050 Q642R0_XENLA MGC84109 protein Xenopus laevis (African clawed frog) 227 76.00% CRYBB2 ARP52061_P050 Q5U5E8_XENLA LOC495288 protein Xenopus laevis (African clawed frog) 196 75.00% CRYBB2 ARP52061_P050 Q6DJC7_XENLA Crybb2‐prov protein (MGC84818 protein) Xenopus laevis (African clawed frog) 204 75.00%

ORF Names:zgc:163121 ZFIN ZDB‐GENE‐ 070424‐80OrganismDanio rerio Glutamate decarboxylase‐like protein 1 (EC Xenopus tropicalis (Western clawed frog) (Zebrafish) (Brachydanio rerio) ARP56000_P050 GADL1_XENTR 4.1.1.‐) (Fragment) (Silurana tropicalis) 511 92.00% robo2 ARP45396_P050 D2KAS8_XENLA Robo 2 (Fragment) Xenopus laevis (African clawed frog) 788 100.00% Xenopus tropicalis (Western clawed frog) phf17 ARP34715_P050 A1A5F9_XENTR Phf17 protein (Silurana tropicalis) 782 92.00% phf17 ARP34715_P050 JADE1_XENLA Protein Jade‐1 (PHD finger protein 17) Xenopus laevis (African clawed frog) 827 92.00% Ribosome maturation protein SBDS (Shwachman‐Bodian‐Diamond syndrome sbds ARP45719_T100 SBDS_XENLA protein homolog) Xenopus laevis (African clawed frog) 250 78.00% ARP40218_T100 Q8AVQ1_XENLA Similar to ribosomal protein L13 Xenopus laevis (African clawed frog) 211 100.00% ARP40218_T100 Q6EE52_XENLA Ribosomal protein L13 (Fragment) Xenopus laevis (African clawed frog) 178 100.00% ARP40218_T100 Q6DJN5_XENLA Rpl13‐prov protein Xenopus laevis (African clawed frog) 211 100.00% ARP40218_T100 A3KMT6_XENLA LOC100049095 protein Xenopus laevis (African clawed frog) 211 100.00% Xenopus tropicalis (Western clawed frog) ARP40218_T100 Q6P639_XENTR Ribosomal protein L13 (Silurana tropicalis) 211 92.00% ORF Names:TVAG_204070 EMBL EAX90272.1OrganismTrichomonas Xenopus tropicalis (Western clawed frog) vaginalis ARP33450_P050 A4IH92_XENTR Putative uncharacterized protein LOC549147 (Silurana tropicalis) 336 100.00% ORF Names:TVAG_204070 EMBL EAX90272.1OrganismTrichomonas DNA repair protein RAD51 homolog B vaginalis ARP33450_P050 RA51B_XENLA (xRAD51.2) Xenopus laevis (African clawed frog) 336 92.00% ORF Names:TVAG_204070 EMBL EAX90272.1OrganismTrichomonas DNA repair protein RAD51 homolog A vaginalis ARP33450_P050 RA51A_XENLA (xRAD51.1) Xenopus laevis (African clawed frog) 336 92.00% Xenopus tropicalis (Western clawed frog) mkl1 ARP37504_T100 A0JM74_XENTR Megakaryoblastic leukemia (Translocation) 1 (Silurana tropicalis) 1033 76.00% ORF Names:GSPATT00009071001 EMBL CAK72679.1OrganismParamecium Xenopus tropicalis (Western clawed frog) tetraurelia ARP41231_P050 B5DEC9_XENTR Putative uncharacterized protein (Silurana tropicalis) 970 92.00% ORF Names:GSPATT00009071001 EMBL CAK72679.1OrganismParamecium tetraurelia ARP41231_P050 Q4KLW4_XENLA MGC114774 protein Xenopus laevis (African clawed frog) 484 75.00% ORF Names:GSPATT00009071001 EMBL CAK72679.1OrganismParamecium Xenopus tropicalis (Western clawed frog) tetraurelia ARP41231_P050 A8E5V3_XENTR LOC100127615 protein (Silurana tropicalis) 484 75.00% Parathyroid hormone related protein pthrP ARP33885_T100 C1L357_XENLA (Fragment) Xenopus laevis (African clawed frog) 124 84.00% ORF Names:PANDA_007553 EMBL EFB27865.1OrganismAiluropoda Xenopus tropicalis (Western clawed frog) melanoleuca (Giant panda) ARP50804_P050 SRFB1_XENTR Isoform 2 (Silurana tropicalis) 530 78.00% ORF Names:PANDA_007553 EMBL Serum response factor‐binding protein 1 (SRF‐ EFB27865.1OrganismAiluropoda dependent transcription regulation‐associated Xenopus tropicalis (Western clawed frog) melanoleuca (Giant panda) ARP50804_P050 SRFB1_XENTR protein) (Silurana tropicalis) 535 78.00% ORF Names:PANDA_007553 EMBL EFB27865.1OrganismAiluropoda melanoleuca (Giant panda) ARP50804_P050 Q7T0Y3_XENLA Flj25286‐prov protein Xenopus laevis (African clawed frog) 480 78.00% Ordered Locus Names:Bcer98_0306OrganismBacillus cereus subsp. cytotoxis (strain NVH 391‐ 98) ARP58417_P050 Q9DEX5_XENLA ALDH1A2 protein (RALDH2) Xenopus laevis (African clawed frog) 518 75.00% Ordered Locus Names:Bcer98_0306OrganismBacillus cereus subsp. cytotoxis (strain NVH 391‐ Aldehyde dehydrogenase 1 family, member Xenopus tropicalis (Western clawed frog) 98) ARP58417_P050 Q28CC8_XENTR A2 (Silurana tropicalis) 511 75.00% Xenopus tropicalis (Western clawed frog) plxna2 ARP49932_P050 B1WB12_XENTR Plxna2 protein (Silurana tropicalis) 1898 84.00% ORF Names:v1g128552OrganismNematostel la vectensis (Starlet sea anemone) ARP34585_T100 Q6DKM0_XENLA MGC83065 protein Xenopus laevis (African clawed frog) 1230 100.00%

ORF Names:v1g128552OrganismNematostel Xenopus tropicalis (Western clawed frog) la vectensis (Starlet sea anemone) ARP34585_T100 Q6DD98_XENTR Cand1 protein (Fragment) (Silurana tropicalis) 175 100.00% ARP43437_P050 Q63ZS2_XENLA LOC494742 protein Xenopus laevis (African clawed frog) 201 100.00% ARP43437_P050 Q63ZH5_XENLA LOC494805 protein Xenopus laevis (African clawed frog) 201 100.00% Xenopus tropicalis (Western clawed frog) ARP43437_P050 B0BM03_XENTR Ube2e2 protein (Silurana tropicalis) 201 100.00% Xenopus tropicalis (Western clawed frog) ARP41743_T100 Q28CV3_XENTR Serine/threonine kinase 11 (Silurana tropicalis) 432 100.00%

Serine/threonine‐protein kinase 11 (EC 2.7.11.1) ( and kinase 1) ARP41743_T100 STK11_XENLA (Serine/threonine‐protein kinase XEEK1) Xenopus laevis (African clawed frog) 432 100.00% ARP30117_T100 Q6PA89_XENLA MGC68689 protein Xenopus laevis (African clawed frog) 227 92.00% Xenopus tropicalis (Western clawed frog) ARP30117_T100 Q6DIK8_XENTR YEATS domain containing 4 (Silurana tropicalis) 227 92.00% si:ch211‐203l9.3 ARP48272_P050 Q3B8E0_XENLA MGC131302 protein Xenopus laevis (African clawed frog) 179 100.00% LOC100135218 protein (Putative Xenopus tropicalis (Western clawed frog) si:ch211‐203l9.3 ARP48272_P050 A9ULM5_XENTR uncharacterized protein LOC100135218) (Silurana tropicalis) 179 92.00% si:ch211‐203l9.3 ARP48272_P050 Q6DJP4_XENLA MGC81898 protein Xenopus laevis (African clawed frog) 219 92.00% si:ch211‐203l9.3 ARP48272_P050 Q66IY0_XENLA MGC84190 protein Xenopus laevis (African clawed frog) 192 78.00% Gabpb1 ARP57863_P050 Q91923_XENLA XrpFIbeta1 Xenopus laevis (African clawed frog) 385 100.00% Gabpb1 ARP57863_P050 Q7ZWX6_XENLA Gabpb1‐prov protein Xenopus laevis (African clawed frog) 385 100.00% GA binding protein transcription factor, beta Xenopus tropicalis (Western clawed frog) Gabpb1 ARP57863_P050 Q68FB9_XENTR subunit 1 (Silurana tropicalis) 404 100.00% GA binding protein transcription factor, beta Xenopus tropicalis (Western clawed frog) Gabpb1 ARP57863_P050 Q28BY9_XENTR subunit 2 (Silurana tropicalis) 385 100.00% Gabpb1 ARP57863_P050 B7ZQV8_XENLA XrpFIbeta1 Xenopus laevis (African clawed frog) 385 100.00%

GATAD2A ARP39299_P050 Q9PUM7_XENLA Mi‐2 histone deacetylase complex protein 66 Xenopus laevis (African clawed frog) 420 92.00% Xenopus tropicalis (Western clawed frog) GATAD2A ARP39299_P050 Q28DK7_XENTR GATA zinc finger domain containing 2A (Silurana tropicalis) 551 92.00% GATAD2A ARP39299_P050 Q08AX4_XENLA LOC100158394 protein Xenopus laevis (African clawed frog) 555 92.00%

GATAD2A ARP39299_P050 B7ZQE1_XENLA Mi‐2 histone deacetylase complex protein 66 Xenopus laevis (African clawed frog) 420 92.00% LOC100135141 protein (Putative Xenopus tropicalis (Western clawed frog) ARP56148_P050 A9JSD7_XENTR uncharacterized protein LOC100135141) (Silurana tropicalis) 194 92.00% 40S ribosomal protein S7 (40S ribosomal ARP56148_P050 RS7_XENLA protein S8) Xenopus laevis (African clawed frog) 194 92.00% Xenopus tropicalis (Western clawed frog) MYB ARP38611_P050 Q4VBE3_XENTR Myb protein (Fragment) (Silurana tropicalis) 759 92.00% MYB ARP38611_P050 MYB_XENLA Transcriptional activator Myb Xenopus laevis (African clawed frog) 624 85.00% Ssb ARP40461_T100 Q7ZTK2_XENLA Ssb‐b protein Xenopus laevis (African clawed frog) 427 78.00% Ssb ARP40461_T100 Q5U545_XENLA Laa‐a protein (Fragment) Xenopus laevis (African clawed frog) 367 78.00% Ssb ARP40461_T100 Q4KLV5_XENLA Laa‐A‐prov protein Xenopus laevis (African clawed frog) 428 78.00% Ssb ARP40461_T100 Q32N81_XENLA Ssb‐b protein Xenopus laevis (African clawed frog) 427 78.00% Ssb ARP40461_T100 B2L4E7_XENBO Lupus LA protein (Fragment) Xenopus borealis (Kenyan clawed frog) 64 78.00%

Lupus La protein homolog B (La autoantigen Ssb ARP40461_T100 LAB_XENLA homolog B) (La ribonucleoprotein B) Xenopus laevis (African clawed frog) 427 78.00%

Lupus La protein homolog A (La autoantigen Ssb ARP40461_T100 LAA_XENLA homolog A) (La ribonucleoprotein A) Xenopus laevis (African clawed frog) 428 78.00% AVARP08005_P050 B7ZS80_XENLA Insulin receptor, beta‐subunit Xenopus laevis (African clawed frog) 1362 85.00%

Insulin receptor (IR) (EC 2.7.10.1) (XTK‐1b) (Xe‐ InsR) [Cleaved into: Insulin receptor subunit AVARP08005_P050 INSR_XENLA alpha; Insulin receptor subunit beta] Xenopus laevis (African clawed frog) 1362 85.00% IMPDH1 ARP54363_P050 Q7ZYP7_XENLA MGC53627 protein Xenopus laevis (African clawed frog) 514 100.00% IMPDH1 ARP54363_P050 Q7ZXT8_XENLA Impdh2‐prov protein Xenopus laevis (African clawed frog) 514 100.00% IMPDH1 ARP54363_P050 Q7ZWN1_XENLA Impdh1‐prov protein Xenopus laevis (African clawed frog) 514 100.00% IMP (Inosine monophosphate) dehydrogenase Xenopus tropicalis (Western clawed frog) IMPDH1 ARP54363_P050 Q66JD5_XENTR 2 (Silurana tropicalis) 514 100.00% IMP (Inosine monophosphate) dehydrogenase Xenopus tropicalis (Western clawed frog) IMPDH1 ARP54363_P050 Q28D47_XENTR 1 (Silurana tropicalis) 514 100.00% Xenopus tropicalis (Western clawed frog) st3gal4 ARP46703_P050 Q703F8_XENTR Alpha 2,3‐sialyltransferase (Silurana tropicalis) 330 78.00% st3gal4 ARP46703_P050 Q4V814_XENLA MGC114856 protein Xenopus laevis (African clawed frog) 326 78.00% ST3 beta‐galactoside alpha‐2,3‐ Xenopus tropicalis (Western clawed frog) st3gal4 ARP46703_P050 Q28CN5_XENTR sialyltransferase 4 (Siat4c protein) (Silurana tropicalis) 326 78.00% ARP31967_P050 Q90YE1_XENLA Homeobox protein Hox C12 (Fragment) Xenopus laevis (African clawed frog) 147 78.00% Xenopus tropicalis (Western clawed frog) Tle3b ARP32359_P050 D2JPI5_XENTR TLE1 (Silurana tropicalis) 780 84.00% DPYSL4 ARP41932_P050 Q6PB02_XENLA MGC68668 protein Xenopus laevis (African clawed frog) 573 85.00% Dihydropyrimidinase‐related protein 3 (DRP‐ Xenopus tropicalis (Western clawed frog) DPYSL4 ARP41932_P050 DPYL3_XENTR 3) (Dihydropyrimidinase‐like 3) (Silurana tropicalis) 571 85.00% Dihydropyrimidinase‐related protein 3‐B (DRP‐ 3‐B) (Collapsin response mediator protein 4) DPYSL4 ARP41932_P050 DPY3B_XENLA (CRMP‐4) (xCRMP4) Xenopus laevis (African clawed frog) 571 85.00% Xenopus tropicalis (Western clawed frog) DPYSL4 ARP41932_P050 Q5EBF5_XENTR Dihydropyrimidinase‐like 4 (Silurana tropicalis) 573 85.00% Dihydropyrimidinase‐related protein 3‐A (DRP‐ DPYSL4 ARP41932_P050 DPY3A_XENLA 3‐A) (Neural‐specific protein 1) Xenopus laevis (African clawed frog) 571 78.00% Xenopus tropicalis (Western clawed frog) .1 ARP39536_P050 B2GU80_XENTR Pknox2 protein (Silurana tropicalis) 468 100.00% pknox1.1 ARP39536_P050 Q32NP1_XENLA MGC131001 protein Xenopus laevis (African clawed frog) 428 90.00% Lasp1 ARP54797_P050 Q7ZXN2_XENLA Lasp1 protein Xenopus laevis (African clawed frog) 256 100.00% Xenopus tropicalis (Western clawed frog) Lasp1 ARP54797_P050 Q66KD2_XENTR LIM and SH3 protein 1 (Lasp1 protein) (Silurana tropicalis) 258 100.00% Lasp1 ARP54797_P050 Q5XGQ5_XENLA LOC495167 protein Xenopus laevis (African clawed frog) 275 92.00% eprs ARP46109_P050 B1H1R9_XENLA LOC100158287 protein Xenopus laevis (African clawed frog) 655 100.00% eprs ARP46109_P050 B1WBE0_XENLA LOC100158438 protein Xenopus laevis (African clawed frog) 1499 92.00% Xenopus tropicalis (Western clawed frog) eprs ARP46109_P050 B0BMK2_XENTR LOC100145057 protein (Fragment) (Silurana tropicalis) 674 92.00% ORF Names:OsI_17752 EMBL EAY95889.1OrganismOryza sativa Nuclear factor related to kappa‐B‐binding Xenopus tropicalis (Western clawed frog) subsp. indica (Rice) ARP34265_P050 NFRKB_XENTR protein (DNA‐binding protein R kappa‐B) (Silurana tropicalis) 1265 76.00% GTF2H1 P100811_T100 Q7ZX12_XENLA Gtf2h1‐prov protein Xenopus laevis (African clawed frog) 532 100.00% GTF2H1 P100811_T100 Q5HZS8_XENLA Putative uncharacterized protein Xenopus laevis (African clawed frog) 172 100.00% General transcription factor IIH, polypeptide Xenopus tropicalis (Western clawed frog) GTF2H1 P100811_T100 Q6DIF6_XENTR 1, 62kDa (Silurana tropicalis) 547 92.00% S38A2 ARP33059_P050 Q6DCL8_XENLA Slc38a2‐prov protein Xenopus laevis (African clawed frog) 491 78.00% Sodium‐coupled neutral amino acid transporter 2 (Amino acid transporter A2) (Solute carrier family 38 member 2) (System A amino acid transporter 2) (System A transporter 1) (System N amino acid Xenopus tropicalis (Western clawed frog) S38A2 ARP33059_P050 S38A2_XENTR transporter 2) (Silurana tropicalis) 493 78.00% Csnk2a2 ARP53595_P050 Q6INF7_XENLA MGC83125 protein Xenopus laevis (African clawed frog) 349 92.00% Csnk2a2 ARP53595_P050 Q6INV5_XENLA Ck2a1 protein Xenopus laevis (African clawed frog) 401 76.00% Casein kinase II subunit alpha (CK II) (EC Csnk2a2 ARP53595_P050 CSK21_XENLA 2.7.11.1) Xenopus laevis (African clawed frog) 392 76.00% cbr‐nipi‐3 ARP48232_P050 Q3KPT6_XENLA MGC131326 protein Xenopus laevis (African clawed frog) 130 100.00% ORF Names:Bm1_14305 EMBL EDP36839.1OrganismBrugia malayi (Filarial nematode worm) ARP55898_P050 Q5PQ97_XENLA LOC495939 protein Xenopus laevis (African clawed frog) 82 92.00% ORF Names:Bm1_14305 EMBL EDP36839.1OrganismBrugia malayi Xenopus tropicalis (Western clawed frog) (Filarial nematode worm) ARP55898_P050 B4F6M5_XENTR Novel HD domain containing protein (Silurana tropicalis) 179 92.00% Guanosine‐3',5'‐bis(diphosphate) 3'‐ pyrophosphohydrolase MESH1 (EC 3.1.7.2) (HD domain‐containing protein 3) (Metazoan ORF Names:Bm1_14305 EMBL SpoT homolog 1) (MESH1) (Penta‐phosphate EDP36839.1OrganismBrugia malayi guanosine‐3'‐pyrophosphohydrolase) Xenopus tropicalis (Western clawed frog) (Filarial nematode worm) ARP55898_P050 MESH1_XENTR ((ppGpp)ase) (Silurana tropicalis) 179 92.00% Xenopus tropicalis (Western clawed frog) ARP36679_T100 B5BNX8_XENTR Runx2 (Silurana tropicalis) 468 92.00% Runt‐related transcription factor 2 type I runx2 ARP36679_T100 A1YIX9_XENLA (Fragment) Xenopus laevis (African clawed frog) 455 92.00% runx2 ARP36679_T100 A1YIX8_XENLA Runt‐related transcription factor 2 type II Xenopus laevis (African clawed frog) 469 84.00%

CanB protein (Protein phospatase 3 regulatory ARP56124_P050 Q7T063_XENLA subunit B alpha isoform type 1) Xenopus laevis (African clawed frog) 170 100.00%

Protein phospatase 3 regulatory subunit B alpha isoform type 1 (Protein phosphatase 3 (Formerly 2B), regulatory subunit B, 19kDa, Xenopus tropicalis (Western clawed frog) ARP56124_P050 Q6VN50_XENTR alpha isoform (Calcineurin B, type I)) (Silurana tropicalis) 170 100.00% ARP56124_P050 Q6DJJ3_XENLA MGC82148 protein Xenopus laevis (African clawed frog) 170 100.00% Xenopus tropicalis (Western clawed frog) Dnajc17 ARP37472_T100 Q28IT2_XENTR Novel protein containing dnaj domain (Silurana tropicalis) 298 92.00% Xenopus tropicalis (Western clawed frog) Dnajc17 ARP37472_T100 Q0IIV7_XENTR Putative uncharacterized protein LOC549987 (Silurana tropicalis) 310 92.00% Dnajc17 ARP37472_T100 Q6PCH3_XENLA MGC69064 protein Xenopus laevis (African clawed frog) 311 91.00% Dnajc17 ARP37472_T100 A5D8P2_XENLA LOC100049763 protein Xenopus laevis (African clawed frog) 320 91.00% ORF Names:GSPATT00010432001 EMBL CAK74198.1OrganismParamecium tetraurelia ARP45700_T100 Q2VPL7_XENLA LOC733431 protein (Fragment) Xenopus laevis (African clawed frog) 285 92.00% ORF Names:GSPATT00010432001 EMBL CAK74198.1OrganismParamecium tetraurelia ARP45700_T100 Q05AV8_XENLA LOC733431 protein Xenopus laevis (African clawed frog) 175 92.00% ORF Names:GSPATT00010432001 EMBL CAK74198.1OrganismParamecium Enoyl Coenzyme A hydratase, short chain, 1, Xenopus tropicalis (Western clawed frog) tetraurelia ARP45700_T100 Q6GLG0_XENTR mitochondrial (Silurana tropicalis) 286 84.00% slc1a4 ARP42247_T100 Q6GM93_XENLA MGC82017 protein Xenopus laevis (African clawed frog) 527 92.00% Solute carrier family 1 (Neutral amino acid Xenopus tropicalis (Western clawed frog) slc1a4 ARP42247_T100 Q66II7_XENTR transporter), member 5 (Silurana tropicalis) 527 92.00% slc1a4 ARP42247_T100 A0JPH6_XENLA LOC100036798 protein Xenopus laevis (African clawed frog) 527 92.00% Xenopus tropicalis (Western clawed frog) slc1a4 ARP42247_T100 A4IIF3_XENTR LOC100124992 protein (Silurana tropicalis) 537 92.00% Xenopus tropicalis (Western clawed frog) ZNF238 ARP35799_P050 ZN238_XENTR Zinc finger protein 238 (Silurana tropicalis) 521 100.00% ZNF238 ARP35799_P050 Z2383_XENLA Zinc finger protein 238.3 Xenopus laevis (African clawed frog) 519 100.00% ZNF238 ARP35799_P050 Z2381_XENLA Zinc finger protein 238 Xenopus laevis (African clawed frog) 520 85.00% NR3C2 ARP45599_T100 Q66J29_XENLA Nr3c2 protein Xenopus laevis (African clawed frog) 979 75.00% Mineralocorticoid receptor (MR) (Nuclear receptor subfamily 3 group C member 2) NR3C2 ARP45599_T100 MCR_XENLA (Fragment) Xenopus laevis (African clawed frog) 612 75.00% ORF Names:PANDA_012057 EMBL EFB28940.1OrganismAiluropoda melanoleuca (Giant panda) ARP52547_P050 Q6AZN0_XENLA Dyx1c1‐prov protein Xenopus laevis (African clawed frog) 421 85.00% ORF Names:PANDA_012057 EMBL EFB28940.1OrganismAiluropoda Xenopus tropicalis (Western clawed frog) melanoleuca (Giant panda) ARP52547_P050 Q5VJS3_XENTR EKN1 (Silurana tropicalis) 411 85.00% ORF Names:PANDA_012057 EMBL EFB28940.1OrganismAiluropoda melanoleuca (Giant panda) ARP52547_P050 Q5VJS2_XENLA EKN1 Xenopus laevis (African clawed frog) 411 85.00% Srp19 ARP40456_T100 Q5XHA6_XENLA LOC495049 protein Xenopus laevis (African clawed frog) 142 85.00% Signal recognition particle (Signal recognition Xenopus tropicalis (Western clawed frog) Srp19 ARP40456_T100 Q5XGC1_XENTR particle 19) (Silurana tropicalis) 142 85.00% ARP38768_T100 Q6IRM6_XENLA LOC397786 protein Xenopus laevis (African clawed frog) 387 92.00% D4, zinc and double PHD fingers family 2 Xenopus tropicalis (Western clawed frog) ARP38768_T100 Q28IH5_XENTR (Fragment) (Silurana tropicalis) 298 92.00% Zinc finger protein ubi‐d4 A (Apoptosis response zinc finger protein A) (Protein ARP38768_T100 REQUA_XENLA requiem A) (xReq A) Xenopus laevis (African clawed frog) 388 92.00% Xenopus tropicalis (Western clawed frog) pcdh19 ARP49343_P050 A8KBB7_XENTR Pcdhac2 protein (Fragment) (Silurana tropicalis) 967 85.00% Xenopus tropicalis (Western clawed frog) pcdh19 ARP49343_P050 A4IIM4_XENTR Pcdhac2 protein (Fragment) (Silurana tropicalis) 967 85.00% Xenopus tropicalis (Western clawed frog) pcdh19 ARP49343_P050 Q5U4Z1_XENTR Protocadherin 18 (Silurana tropicalis) 1145 83.00% Xenopus tropicalis (Western clawed frog) pcdh19 ARP49343_P050 Q0IHR9_XENTR Pcdha13 protein (Fragment) (Silurana tropicalis) 911 78.00% pcdh19 ARP49343_P050 D9N4D2_XENLA Protocadherin 18 (Fragment) Xenopus laevis (African clawed frog) 676 83.00% Xenopus tropicalis (Western clawed frog) pcdh19 ARP49343_P050 B0Z663_XENTR Protocadherin delta 1 (Silurana tropicalis) 958 78.00% pcdh19 ARP49343_P050 Q284V9_XENLA Protocadherin PCNS Xenopus laevis (African clawed frog) 977 76.00% pcdh19 ARP49343_P050 Q7ZX86_XENLA MGC53493 protein Xenopus laevis (African clawed frog) 927 78.00% Xenopus tropicalis (Western clawed frog) pcdh19 ARP49343_P050 A4IHH7_XENTR Putative uncharacterized protein (Silurana tropicalis) 931 76.00% ORF Names:PANDA_015632 EMBL EFB19629.1OrganismAiluropoda La‐related protein 7 (La ribonucleoprotein Xenopus tropicalis (Western clawed frog) melanoleuca (Giant panda) ARP40848_T100 LARP7_XENTR domain family member 7) (Silurana tropicalis) 593 92.00% DKFZp469B2416 ARP39233_P050 Q6GN20_XENLA MGC83625 protein Xenopus laevis (African clawed frog) 474 100.00% Xenopus tropicalis (Western clawed frog) DKFZp469B2416 ARP39233_P050 B3DLW7_XENTR Sufu protein (Silurana tropicalis) 474 100.00% ARP52532_P050 Q66KV7_XENLA MGC85390 protein Xenopus laevis (African clawed frog) 278 85.00% ARP52532_P050 Q4V848_XENLA MGC114680 protein Xenopus laevis (African clawed frog) 278 85.00% Xenopus tropicalis (Western clawed frog) ARP52532_P050 Q0VFS3_XENTR RAB40B, member RAS oncogene family (Silurana tropicalis) 278 85.00% Glycerol‐3‐phosphate dehydrogenase 1‐like Xenopus tropicalis (Western clawed frog) ARP55177_P050 GPD1L_XENTR protein (EC 1.1.1.8) (Silurana tropicalis) 352 100.00% Glycerol‐3‐phosphate dehydrogenase 1‐like ARP55177_P050 GPD1L_XENLA protein (EC 1.1.1.8) Xenopus laevis (African clawed frog) 352 100.00% ARP55177_P050 Q6GN03_XENLA MGC83663 protein Xenopus laevis (African clawed frog) 349 78.00% ARP55177_P050 Q7ZYM3_XENLA Gpd1 protein Xenopus laevis (African clawed frog) 348 100.00% Glycerol‐3‐phosphate dehydrogenase 1 (Soluble) (Glycerol‐3‐phosphate Xenopus tropicalis (Western clawed frog) ARP55177_P050 Q6DFQ1_XENTR dehydrogenase 1‐like) (Silurana tropicalis) 348 100.00% tmf1 P100705_P050 A1L2N9_XENLA LOC100036905 protein Xenopus laevis (African clawed frog) 1092 92.00% ORF Names:ACLA_022100 EMBL EAW07496.1OrganismAspergillus Xenopus tropicalis (Western clawed frog) clavatus ARP46021_P050 ARP2_XENTR Actin‐related protein 2 (Actin‐like protein 2) (Silurana tropicalis) 394 100.00% ORF Names:ACLA_022100 EMBL EAW07496.1OrganismAspergillus Actin‐related protein 2‐B (Actin‐like protein 2‐ clavatus ARP46021_P050 ARP2B_XENLA B) Xenopus laevis (African clawed frog) 394 100.00% ORF Names:ACLA_022100 EMBL EAW07496.1OrganismAspergillus Actin‐related protein 2‐A (Actin‐like protein 2‐ clavatus ARP46021_P050 ARP2A_XENLA A) Xenopus laevis (African clawed frog) 394 100.00% ORF Names:Bm1_33785 EMBL EDP33183.1OrganismBrugia malayi Frequenin homolog (Drosophila) (Putative Xenopus tropicalis (Western clawed frog) (Filarial nematode worm) ARP34711_P050 Q6P844_XENTR uncharacterized protein MGC75953) (Silurana tropicalis) 190 100.00% ORF Names:Bm1_33785 EMBL EDP33183.1OrganismBrugia malayi (Filarial nematode worm) ARP34711_P050 Q6IP34_XENLA MGC78985 protein Xenopus laevis (African clawed frog) 190 100.00% ORF Names:Bm1_33785 EMBL EDP33183.1OrganismBrugia malayi Neuronal calcium sensor 1 (NCS‐1) (Filarial nematode worm) ARP34711_P050 NCS1_XENLA (Frequenin) Xenopus laevis (African clawed frog) 190 100.00% Transcription initiation factor TFIID subunit 6 (xTAF6) (Transcription initiation factor TFIID 60 kDa subunit) (TAF(II)60) (TAFII‐60) (TAFII60) (Transcription initiation factor TFIID 70 kDa subunit) (TAF(II)70) (TAFII‐70) taf6 ARP34693_T100 TAF6_XENLA (TAFII70) Xenopus laevis (African clawed frog) 618 85.00% ARP35376_P050 Q4V7H9_XENLA MGC115691 protein Xenopus laevis (African clawed frog) 470 85.00% ARP35376_P050 Q08B60_XENLA LOC100158342 protein Xenopus laevis (African clawed frog) 470 90.00% JUN ARP38133_T100 Q9PVZ0_XENLA C‐Jun protein Xenopus laevis (African clawed frog) 314 92.00% JUN ARP38133_T100 Q6GLS7_XENLA C‐Jun protein Xenopus laevis (African clawed frog) 314 92.00% JUN ARP38133_T100 Q9PVZ1_XENLA C‐Jun protein Xenopus laevis (African clawed frog) 312 84.00% JUN ARP38133_T100 Q8AVE4_XENLA Jun protein Xenopus laevis (African clawed frog) 312 84.00% SIM1 ARP38549_P050 Q9DDU6_XENLA Single‐minded Xenopus laevis (African clawed frog) 760 85.00% Xenopus tropicalis (Western clawed frog) zmynd11 ARP34704_T100 B4F738_XENTR Zmynd11 protein (Silurana tropicalis) 622 78.00% Xenopus tropicalis (Western clawed frog) zmynd11 ARP34704_T100 A4IIZ1_XENTR Zmynd11 protein (Silurana tropicalis) 604 78.00% Dkc1 ARP40357_P050 Q2VPE9_XENLA LOC733436 protein (Fragment) Xenopus laevis (African clawed frog) 510 85.00% Dkc1 ARP40357_P050 Q05AV9_XENLA LOC733436 protein (Fragment) Xenopus laevis (African clawed frog) 450 85.00% Xenopus tropicalis (Western clawed frog) Dkc1 ARP40357_P050 B0BMM6_XENTR LOC100145077 protein (Fragment) (Silurana tropicalis) 502 85.00% Dkc1 ARP40357_P050 A2BD79_XENLA LOC733436 protein (Fragment) Xenopus laevis (African clawed frog) 474 85.00% ORF Names:CpipJ_CPIJ007980 EMBL EDS31071.1OrganismCulex quinquefasciatus (Southern house mosquito) (Culex pungens) ARP40496_T100 Q6GNR8_XENLA MGC80927 protein Xenopus laevis (African clawed frog) 626 78.00% ORF Names:CpipJ_CPIJ007980 EMBL EDS31071.1OrganismCulex quinquefasciatus (Southern house Xenopus tropicalis (Western clawed frog) mosquito) (Culex pungens) ARP40496_T100 Q6DF12_XENTR Polyadenylate‐binding protein 1 (Silurana tropicalis) 634 78.00% ORF Names:CpipJ_CPIJ007980 EMBL EDS31071.1OrganismCulex quinquefasciatus (Southern house Poly(A) binding protein, cytoplasmic 4 Xenopus tropicalis (Western clawed frog) mosquito) (Culex pungens) ARP40496_T100 Q5FVZ8_XENTR (Inducible form) (Silurana tropicalis) 217 78.00% ORF Names:CpipJ_CPIJ007980 EMBL EDS31071.1OrganismCulex Polyadenylate‐binding protein 1‐B (PABP‐1‐B) quinquefasciatus (Southern house (Poly(A)‐binding protein 1‐B) (xPABP1‐B) mosquito) (Culex pungens) ARP40496_T100 PABPB_XENLA (Cytoplasmic poly(A)‐binding protein 1‐B) Xenopus laevis (African clawed frog) 633 78.00%

ORF Names:v1g243312OrganismNematostel la vectensis (Starlet sea anemone) ARP42951_P050 Q7ZTL9_XENLA Ube3a‐prov protein Xenopus laevis (African clawed frog) 908 92.00% ORF Ubiquitin protein ligase E3A (Human Names:v1g243312OrganismNematostel papilloma virus E6‐associated protein, Xenopus tropicalis (Western clawed frog) la vectensis (Starlet sea anemone) ARP42951_P050 Q6NVK6_XENTR Angelman syndrome) (Silurana tropicalis) 856 92.00% Xenopus tropicalis (Western clawed frog) SULT1 ARP49130_P050 Q6P8G4_XENTR Putative uncharacterized protein MGC75696 (Silurana tropicalis) 287 85.00% LOC733517 protein (Novel protein containing Xenopus tropicalis (Western clawed frog) SULT1 ARP49130_P050 Q28HS2_XENTR Sulfotransferase domain) (Silurana tropicalis) 303 92.00% SULT1 ARP49130_P050 Q5EAW0_XENLA MGC85017 protein Xenopus laevis (African clawed frog) 303 92.00% SULT1 ARP49130_P050 Q66KH3_XENLA MGC82150 protein Xenopus laevis (African clawed frog) 290 84.00% Xenopus tropicalis (Western clawed frog) SULT1 ARP49130_P050 Q6GL93_XENTR MGC69544 protein (Silurana tropicalis) 299 85.00% SULT1 ARP49130_P050 Q5M7C2_XENLA LOC496246 protein Xenopus laevis (African clawed frog) 287 84.00% Xenopus tropicalis (Western clawed frog) SULT1 ARP49130_P050 B0BMP3_XENTR LOC100145082 protein (Silurana tropicalis) 304 85.00% Xenopus tropicalis (Western clawed frog) SULT1 ARP49130_P050 B0BM84_XENTR LOC100144988 protein (Silurana tropicalis) 287 84.00% Xenopus tropicalis (Western clawed frog) SULT1 ARP49130_P050 Q05AZ4_XENTR LOC779590 protein (Fragment) (Silurana tropicalis) 288 78.00% Xenopus tropicalis (Western clawed frog) SULT1 ARP49130_P050 A9JTJ7_XENTR LOC779590 protein (Silurana tropicalis) 294 78.00% SULT1 ARP49130_P050 Q7SZ93_XENLA MGC64389 protein Xenopus laevis (African clawed frog) 294 84.00% SULT1 ARP49130_P050 Q6GP49_XENLA MGC80677 protein Xenopus laevis (African clawed frog) 297 84.00% SULT1 ARP49130_P050 Q68EV4_XENLA MGC84291 protein Xenopus laevis (African clawed frog) 276 76.00% Xenopus tropicalis (Western clawed frog) SULT1 ARP49130_P050 B0BLT9_XENTR LOC100144919 protein (Silurana tropicalis) 286 84.00% SULT1 ARP49130_P050 A1L3M6_XENLA LOC100037047 protein Xenopus laevis (African clawed frog) 284 84.00% SULT1 ARP49130_P050 Q4FZP1_XENLA MGC116499 protein Xenopus laevis (African clawed frog) 302 76.00% SULT1 ARP49130_P050 B7ZSE1_XENLA LOC100126626 protein Xenopus laevis (African clawed frog) 304 78.00% SULT1 ARP49130_P050 B7ZSE0_XENLA LOC100126626 protein Xenopus laevis (African clawed frog) 304 78.00% SULT1 ARP49130_P050 A8E5Z0_XENLA LOC100126626 protein Xenopus laevis (African clawed frog) 304 78.00% Xenopus tropicalis (Western clawed frog) SULT1 ARP49130_P050 Q6DJ68_XENTR MGC88979 protein (Silurana tropicalis) 304 84.00% Xenopus tropicalis (Western clawed frog) SULT1 ARP49130_P050 A4IH93_XENTR LOC100124815 protein (Silurana tropicalis) 308 76.00% BLZF1 ARP38376_P050 Q5XGL9_XENLA LOC495190 protein Xenopus laevis (African clawed frog) 389 100.00% BLZF1 ARP38376_P050 Q6NU39_XENLA MGC81269 protein Xenopus laevis (African clawed frog) 389 100.00% Xenopus tropicalis (Western clawed frog) BLZF1 ARP38376_P050 Q66JG4_XENTR Blzf1 protein (Silurana tropicalis) 389 100.00% Xenopus tropicalis (Western clawed frog) BLZF1 ARP38376_P050 Q28DM8_XENTR Basic nuclear factor 1 (JEM‐1) (Silurana tropicalis) 389 100.00% Basic leucine zipper nuclear factor 1 BLZF1 ARP38376_P050 B2L410_XENBO (Fragment) Xenopus borealis (Kenyan clawed frog) 22 100.00% Gamma‐aminobutyric acid A receptor subunit ARP34981_T100 E5LEX6_XENLA alpha‐3 (Fragment) Xenopus laevis (African clawed frog) 368 84.00% ORF Names:GSPATT00004817001 EMBL CAK58445.1OrganismParamecium Xenopus tropicalis (Western clawed frog) tetraurelia ARP58512_P050 B0BM49_XENTR LOC100144965 protein (Fragment) (Silurana tropicalis) 274 100.00% ORF Names:GSPATT00004817001 EMBL Peflin (PEF protein with a long N‐terminal CAK58445.1OrganismParamecium hydrophobic domain) (Penta‐EF hand domain‐ tetraurelia ARP58512_P050 PEF1_XENLA containing protein 1) Xenopus laevis (African clawed frog) 283 100.00% ORF Names:GSPATT00004817001 EMBL CAK58445.1OrganismParamecium tetraurelia ARP58512_P050 A2BDB5_XENLA LOC100037090 protein (Fragment) Xenopus laevis (African clawed frog) 277 91.00% ORF Names:GSPATT00007012001 EMBL CAK68801.1, GSPATT00012810001 EMBL CAK77302.1, GSPATT00013199001 EMBL CAK77734.1, GSPATT00016658001 EMBL CAK81845.1OrganismParamecium Xenopus tropicalis (Western clawed frog) tetraurelia ARP34302_P050 CP080_XENTR UPF0468 protein C16orf80 homolog (Silurana tropicalis) 193 100.00% ORF Names:GSPATT00007012001 EMBL CAK68801.1, GSPATT00012810001 EMBL CAK77302.1, GSPATT00013199001 EMBL CAK77734.1, GSPATT00016658001 EMBL CAK81845.1OrganismParamecium tetraurelia ARP34302_P050 CP080_XENLA UPF0468 protein C16orf80 homolog Xenopus laevis (African clawed frog) 193 100.00% Collagen type IV alpha‐3‐binding protein Xenopus tropicalis (Western clawed frog) COL4A3BP ARP52418_P050 C43BP_XENTR (Ceramide transfer protein) (Silurana tropicalis) 617 92.00% Collagen type IV alpha‐3‐binding protein COL4A3BP ARP52418_P050 C43BP_XENLA (Ceramide transfer protein) Xenopus laevis (African clawed frog) 617 92.00% LOC100037184 ARP48157_P050 Q7ZYR1_XENLA Rpl3‐prov protein Xenopus laevis (African clawed frog) 403 100.00% Xenopus tropicalis (Western clawed frog) LOC100037184 ARP48157_P050 B0BM43_XENTR LOC100145083 protein (Silurana tropicalis) 403 100.00% LOC100037184 ARP48157_P050 A2VD81_XENLA LOC100037184 protein Xenopus laevis (African clawed frog) 405 85.00% btbd3 ARP34341_P050 Q5XGU7_XENLA BTB domain protein 3 (LOC495136 protein) Xenopus laevis (African clawed frog) 519 78.00% Xenopus tropicalis (Western clawed frog) btbd3 ARP34341_P050 A1A5E8_XENTR LOC100036676 protein (Silurana tropicalis) 518 78.00% Xenopus tropicalis (Western clawed frog) zbtb26 ARP39458_P050 Q28EM0_XENTR Zinc finger and BTB domain containing 26 (Silurana tropicalis) 415 85.00% Xenopus tropicalis (Western clawed frog) SKCa ARP35439_P050 B1H397_XENTR LOC100145581 protein (Silurana tropicalis) 231 92.00% Xenopus tropicalis (Western clawed frog) SKCa ARP35439_P050 Q0P4T6_XENTR Putative uncharacterized protein MGC145919 (Silurana tropicalis) 540 85.00% CUGBP Elav‐like family member 1 (CELF‐1) (Bruno‐like protein 2) (CUG triplet repeat RNA‐ binding protein 1) (CUG‐BP1) (CUG‐BP‐ and ETR‐3‐like factor 1) (RNA‐binding protein Xenopus tropicalis (Western clawed frog) ARP40327_P050 CELF1_XENTR BRUNOL‐2) (Silurana tropicalis) 490 100.00%

CUGBP Elav‐like family member 1‐B (CELF‐1B) (Bruno‐like protein 2‐B) (CUG triplet repeat RNA‐binding protein 1‐B) (CUG‐BP1‐B) (CUG‐ BP‐ and ETR‐3‐like factor 1‐B) (Embryo deadenylation element‐binding protein B) (EDEN‐BP‐B) (RNA‐binding protein BRUNOL‐2‐ ARP40327_P050 CEL1B_XENLA B) (p53/p55) Xenopus laevis (African clawed frog) 489 100.00%

CUGBP Elav‐like family member 1‐A (CELF‐1A) (Bruno‐like protein 2‐A) (CUG triplet repeat RNA‐binding protein 1‐A) (CUG‐BP1‐A) (CUG‐ BP‐ and ETR‐3‐like factor 1‐A) (Embryo deadenylation element‐binding protein A) (EDEN‐BP‐A) (RNA‐binding protein BRUNOL‐2‐ ARP40327_P050 CEL1A_XENLA A) (p53/p55) Xenopus laevis (African clawed frog) 489 100.00% ARP40327_P050 B5LEQ4_XENLA RNA binding protein Bruno‐like 3b Xenopus laevis (African clawed frog) 493 92.00% ARP40327_P050 CELF2_XENLA Isoform 2 Xenopus laevis (African clawed frog) 538 92.00% CUGBP Elav‐like family member 2 (CELF‐2) (Bruno‐like protein 3) (CUG triplet repeat RNA‐ binding protein 2) (CUG‐BP2) (CUG‐BP‐ and ETR‐3‐like factor 2) (ELAV‐type RNA‐binding protein 3) (ETR‐3) (RNA‐binding protein Xenopus tropicalis (Western clawed frog) ARP40327_P050 CELF2_XENTR BRUNOL‐3) (Silurana tropicalis) 513 92.00% CUGBP Elav‐like family member 2 (CELF‐2) (Bruno‐like protein 3) (CUG triplet repeat RNA‐ binding protein 2) (CUG‐BP2) (CUG‐BP‐ and ETR‐3‐like factor 2) (ELAV‐type RNA‐binding protein 3) (ETR‐3) (RNA‐binding protein ARP40327_P050 CELF2_XENLA BRUNOL‐3) Xenopus laevis (African clawed frog) 536 92.00% ARP40324_P050 B5LEQ4_XENLA RNA binding protein Bruno‐like 3b Xenopus laevis (African clawed frog) 493 100.00% ARP40324_P050 CELF2_XENLA Isoform 2 Xenopus laevis (African clawed frog) 538 100.00% CUGBP Elav‐like family member 2 (CELF‐2) (Bruno‐like protein 3) (CUG triplet repeat RNA‐ binding protein 2) (CUG‐BP2) (CUG‐BP‐ and ETR‐3‐like factor 2) (ELAV‐type RNA‐binding protein 3) (ETR‐3) (RNA‐binding protein Xenopus tropicalis (Western clawed frog) ARP40324_P050 CELF2_XENTR BRUNOL‐3) (Silurana tropicalis) 513 100.00% CUGBP Elav‐like family member 2 (CELF‐2) (Bruno‐like protein 3) (CUG triplet repeat RNA‐ binding protein 2) (CUG‐BP2) (CUG‐BP‐ and ETR‐3‐like factor 2) (ELAV‐type RNA‐binding protein 3) (ETR‐3) (RNA‐binding protein ARP40324_P050 CELF2_XENLA BRUNOL‐3) Xenopus laevis (African clawed frog) 536 100.00% CUGBP Elav‐like family member 1 (CELF‐1) (Bruno‐like protein 2) (CUG triplet repeat RNA‐ binding protein 1) (CUG‐BP1) (CUG‐BP‐ and ETR‐3‐like factor 1) (RNA‐binding protein Xenopus tropicalis (Western clawed frog) ARP40324_P050 CELF1_XENTR BRUNOL‐2) (Silurana tropicalis) 490 92.00%

CUGBP Elav‐like family member 1‐B (CELF‐1B) (Bruno‐like protein 2‐B) (CUG triplet repeat RNA‐binding protein 1‐B) (CUG‐BP1‐B) (CUG‐ BP‐ and ETR‐3‐like factor 1‐B) (Embryo deadenylation element‐binding protein B) (EDEN‐BP‐B) (RNA‐binding protein BRUNOL‐2‐ ARP40324_P050 CEL1B_XENLA B) (p53/p55) Xenopus laevis (African clawed frog) 489 92.00%

CUGBP Elav‐like family member 1‐A (CELF‐1A) (Bruno‐like protein 2‐A) (CUG triplet repeat RNA‐binding protein 1‐A) (CUG‐BP1‐A) (CUG‐ BP‐ and ETR‐3‐like factor 1‐A) (Embryo deadenylation element‐binding protein A) (EDEN‐BP‐A) (RNA‐binding protein BRUNOL‐2‐ ARP40324_P050 CEL1A_XENLA A) (p53/p55) Xenopus laevis (African clawed frog) 489 92.00% ORF Names:zgc:162316 EMBL AAI34960.1 ZFIN ZDB‐GENE‐070410‐ 70OrganismDanio rerio (Zebrafish) (Brachydanio rerio) ARP32721_P050 Q6GPN8_XENLA LOC443622 protein (Fragment) Xenopus laevis (African clawed frog) 541 92.00% ORF Names:zgc:162316 EMBL AAI34960.1 ZFIN ZDB‐GENE‐070410‐ 70OrganismDanio rerio (Zebrafish) Xenopus tropicalis (Western clawed frog) (Brachydanio rerio) ARP32721_P050 A9JTQ3_XENTR LOC100127821 protein (Silurana tropicalis) 522 92.00% Histone chaperone asf1a‐A (Anti‐silencing function protein 1 homolog) (XAsf1) (Anti‐ Asf1b ARP46276_P050 AS1AA_XENLA silencing function protein 1 homolog A‐A) Xenopus laevis (African clawed frog) 201 92.00% Histone chaperone asf1b (Anti‐silencing Xenopus tropicalis (Western clawed frog) Asf1b ARP46276_P050 ASF1B_XENTR function protein 1 homolog B) (Silurana tropicalis) 200 85.00%

Histone chaperone asf1a‐B (Anti‐silencing Asf1b ARP46276_P050 AS1AB_XENLA function protein 1 homolog A‐B) Xenopus laevis (African clawed frog) 200 78.00% Transcription factor 21 (TCF‐21) (Capsulin) (Epicardin) (Podocyte‐expressed 1) (Pod 1) Xenopus tropicalis (Western clawed frog) tcf21 ARP38274_P050 TCF21_XENTR (Pod‐1) (Silurana tropicalis) 179 78.00% Transcription factor 21 (TCF‐21) (Capsulin) (Epicardin) (Podocyte‐expressed 1) (Pod 1) tcf21 ARP38274_P050 TCF21_XENLA (Pod‐1) Xenopus laevis (African clawed frog) 179 78.00% ORF Names:PANDA_000003 EMBL EFB22202.1OrganismAiluropoda melanoleuca (Giant panda) ARP56199_P050 AKTPB_XENLA AKT‐interacting protein homolog B Xenopus laevis (African clawed frog) 292 91.00% ORF Names:PANDA_000003 EMBL EFB22202.1OrganismAiluropoda melanoleuca (Giant panda) ARP56199_P050 AKTPA_XENLA AKT‐interacting protein homolog A Xenopus laevis (African clawed frog) 293 91.00% ORF Names:PANDA_000003 EMBL EFB22202.1OrganismAiluropoda AKT‐interacting protein (Fused toes protein Xenopus tropicalis (Western clawed frog) melanoleuca (Giant panda) ARP56199_P050 AKTIP_XENTR homolog) (Silurana tropicalis) 292 91.00% ARP45385_P050 Q7SZ04_XENLA LOC398636 protein (Fragment) Xenopus laevis (African clawed frog) 500 92.00%

ARP45385_P050 Q561L4_XENLA Putative uncharacterized protein (Fragment) Xenopus laevis (African clawed frog) 447 92.00% Xenopus tropicalis (Western clawed frog) ARP45385_P050 A4IJ13_XENTR LOC100125100 protein (Silurana tropicalis) 656 92.00% ARP51259_T100 Q7ZWU4_XENLA Sip‐prov protein Xenopus laevis (African clawed frog) 226 85.00% ARP51259_T100 Q6GLM4_XENLA MGC84712 protein Xenopus laevis (African clawed frog) 173 85.00% Xenopus tropicalis (Western clawed frog) ARP51259_T100 Q5U4Q1_XENTR Calcyclin binding protein (Silurana tropicalis) 226 85.00% ORF Names:CpipJ_CPIJ006616 EMBL EDS27613.1OrganismCulex quinquefasciatus (Southern house mosquito) (Culex pungens) ARP40444_P050 Q8AVT2_XENLA Snrpn‐prov protein Xenopus laevis (African clawed frog) 236 92.00% ORF Names:CpipJ_CPIJ006616 EMBL EDS27613.1OrganismCulex quinquefasciatus (Southern house Xenopus tropicalis (Western clawed frog) mosquito) (Culex pungens) ARP40444_P050 Q6NX14_XENTR SNRPN upstream reading frame (Silurana tropicalis) 237 92.00% ORF Names:CpipJ_CPIJ006616 EMBL EDS27613.1OrganismCulex quinquefasciatus (Southern house mosquito) (Culex pungens) ARP40444_P050 Q2VPN2_XENLA MGC130840 protein Xenopus laevis (African clawed frog) 234 92.00% ORF Names:CpipJ_CPIJ006616 EMBL EDS27613.1OrganismCulex quinquefasciatus (Southern house mosquito) (Culex pungens) ARP40444_P050 Q0IHK1_XENLA Snrpn protein Xenopus laevis (African clawed frog) 236 92.00%

Pleiotrophin‐B (PTN‐B) (Pleiotrophic factor‐ Ptn ARP45356_P050 PTNB_XENLA beta‐2) (PTF‐beta‐2) (X‐PTF‐beta2) Xenopus laevis (African clawed frog) 161 85.00%

Pleiotrophin‐A (PTN‐A) (Pleiotrophic factor‐ Ptn ARP45356_P050 PTNA_XENLA beta‐1) (PTF‐beta‐1) (X‐PTF‐beta1) Xenopus laevis (African clawed frog) 161 85.00% Protein arginine N‐methyltransferase 1 (EC 2.1.1.‐) (Heterogeneous nuclear ribonucleoprotein methyltransferase‐like protein 2) (Histone‐arginine N‐ Xenopus tropicalis (Western clawed frog) ARP40193_T100 ANM1_XENTR methyltransferase PRMT1) (EC 2.1.1.125) (Silurana tropicalis) 351 92.00%

Protein arginine N‐methyltransferase 1‐B (xPRMT1b) (EC 2.1.1.‐) (Arginine methyltransferase 1b) (Histone‐arginine N‐ ARP40193_T100 ANM1B_XENLA methyltransferase PRMT1‐B) (EC 2.1.1.125) Xenopus laevis (African clawed frog) 351 92.00% ARP40193_T100 ANM1A_XENLA Isoform 2 Xenopus laevis (African clawed frog) 351 92.00%

Protein arginine N‐methyltransferase 1‐A (xPRMT1) (EC 2.1.1.‐) (Histone‐arginine N‐ ARP40193_T100 ANM1A_XENLA methyltransferase PRMT1‐A) (EC 2.1.1.125) Xenopus laevis (African clawed frog) 369 92.00% Barhl1 ARP32659_P050 Q9DFC3_XENLA Bar homeobox protein XBH2 (Fragment) Xenopus laevis (African clawed frog) 322 100.00% Barhl1 ARP32659_P050 B7ZRB9_XENLA Putative uncharacterized protein Xenopus laevis (African clawed frog) 361 100.00% Barhl1 ARP32659_P050 Q9DFC4_XENLA Bar homeobox protein XBH1 Xenopus laevis (African clawed frog) 365 92.00%

ORF Names:TRIADDRAFT_62499 EMBL EDV19050.1OrganismTrichoplax Xenopus tropicalis (Western clawed frog) adhaerens (Trichoplax reptans) ARP55397_P050 B5DE18_XENTR Putative uncharacterized protein (Silurana tropicalis) 587 100.00%

ORF Names:TRIADDRAFT_62499 EMBL EDV19050.1OrganismTrichoplax adhaerens (Trichoplax reptans) ARP55397_P050 PHAR1_XENLA Phosphatase and actin regulator 1 Xenopus laevis (African clawed frog) 586 100.00% ckm ARP41476_P050 Q7ZYQ9_XENLA Ckm‐prov protein Xenopus laevis (African clawed frog) 381 100.00% ckm ARP41476_P050 Q7LZG8_XENLA Creatine kinase (EC 2.7.3.2) (Fragment) Xenopus laevis (African clawed frog) 302 100.00% Xenopus tropicalis (Western clawed frog) ckm ARP41476_P050 Q6P347_XENTR Creatine kinase, muscle (Silurana tropicalis) 381 100.00% Xenopus tropicalis (Western clawed frog) ckm ARP41476_P050 Q28GS7_XENTR Creatine kinase, brain (Silurana tropicalis) 381 78.00% Xenopus tropicalis (Western clawed frog) RBM47 ARP40932_P050 B4F6J4_XENTR Putative uncharacterized protein (Silurana tropicalis) 412 92.00% TC2N ARP52895_P050 Q5M7E7_XENLA LOC496221 protein Xenopus laevis (African clawed frog) 484 84.00% ORF Names:ACLA_069120 EMBL EAW13884.1OrganismAspergillus Xenopus tropicalis (Western clawed frog) clavatus ARP56185_P050 Q5RJJ6_XENTR Ribosomal protein S15 (Silurana tropicalis) 145 100.00% ORF Names:ACLA_069120 EMBL EAW13884.1OrganismAspergillus clavatus ARP56185_P050 RS15_XENLA 40S ribosomal protein S15 (RIG protein) Xenopus laevis (African clawed frog) 145 100.00% Xenopus tropicalis (Western clawed frog) dpp6 ARP44867_P050 A4IIX6_XENTR LOC100125080 protein (Silurana tropicalis) 846 92.00% brd3 ARP34431_P050 A1L1G8_XENLA LOC100036838 protein Xenopus laevis (African clawed frog) 783 92.00% Xenopus tropicalis (Western clawed frog) ARP32987_P050 B3DM21_XENTR LOC100170591 protein (Silurana tropicalis) 76 92.00% ARP32987_P050 Q6DE65_XENLA MGC80050 protein Xenopus laevis (African clawed frog) 76 85.00% ORF Names:KHVJ168 EMBL BAF48972.1OrganismCyprinid E3 ubiquitin‐protein ligase arkadia (EC 6.3.2.‐) Xenopus tropicalis (Western clawed frog) herpesvirus 3 ARP43225_P050 RN111_XENTR (RING finger protein 111) (Silurana tropicalis) 954 92.00% ORF Names:KHVJ168 EMBL BAF48972.1OrganismCyprinid E3 ubiquitin‐protein ligase arkadia‐B (EC 6.3.2.‐ herpesvirus 3 ARP43225_P050 R111B_XENLA ) (RING finger protein 111‐B) Xenopus laevis (African clawed frog) 959 92.00% ORF Names:KHVJ168 EMBL BAF48972.1OrganismCyprinid E3 ubiquitin‐protein ligase arkadia‐C (EC 6.3.2.‐ herpesvirus 3 ARP43225_P050 R111C_XENLA ) (RING finger protein 111‐C) Xenopus laevis (African clawed frog) 967 85.00% ORF Names:KHVJ168 EMBL BAF48972.1OrganismCyprinid E3 ubiquitin‐protein ligase arkadia‐A (EC 6.3.2.‐ herpesvirus 3 ARP43225_P050 R111A_XENLA ) (RING finger protein 111‐A) (Fragment) Xenopus laevis (African clawed frog) 923 85.00% PRKAA2 ARP53652_P050 Q8UVW8_XENLA SNF1‐like protein AMPK Xenopus laevis (African clawed frog) 560 100.00% PRKAA2 ARP53652_P050 Q5U5E3_XENLA LOC495290 protein Xenopus laevis (African clawed frog) 560 100.00% Xenopus tropicalis (Western clawed frog) PRKAA2 ARP53652_P050 B4F6W2_XENTR Putative uncharacterized protein (Silurana tropicalis) 551 92.00% Xenopus tropicalis (Western clawed frog) PRKAA2 ARP53652_P050 B1H2Z8_XENTR LOC100145520 protein (Silurana tropicalis) 551 92.00% TFCP2 ARP31073_P050 Q7T0B5_XENLA Transcription factor LSF Xenopus laevis (African clawed frog) 506 85.00% TFCP2 ARP31073_P050 Q3KQ94_XENLA Putative uncharacterized protein Xenopus laevis (African clawed frog) 301 85.00% Xenopus tropicalis (Western clawed frog) TFCP2 ARP31073_P050 TFCP2_XENTR Transcription factor CP2 (Silurana tropicalis) 507 85.00% TFCP2 ARP31073_P050 TFCP2_XENLA Transcription factor CP2 Xenopus laevis (African clawed frog) 506 85.00% ARP40174_P050 Q32NP0_XENLA MGC131002 protein Xenopus laevis (African clawed frog) 376 100.00% Xenopus tropicalis (Western clawed frog) ARP40174_P050 B3DLR0_XENTR LOC100170531 protein (Silurana tropicalis) 375 100.00% Ubiquitin‐like domain‐containing CTD Xenopus tropicalis (Western clawed frog) ublcp1 ARP52791_P050 UBCP1_XENTR phosphatase 1 (EC 3.1.3.16) (Silurana tropicalis) 318 78.00% Ubiquitin‐like domain‐containing CTD ublcp1 ARP52791_P050 UBCP1_XENLA phosphatase 1 (EC 3.1.3.16) Xenopus laevis (African clawed frog) 318 78.00% Xenopus tropicalis (Western clawed frog) dhh ARP45230_T100 B0JYS3_XENTR LOC100145111 protein (Fragment) (Silurana tropicalis) 273 100.00%

Indian hedgehog protein (IHH) (Banded hedgehog protein) (X‐BHH) [Cleaved into: Indian hedgehog protein N‐product; Indian dhh ARP45230_T100 IHH_XENLA hedgehog protein C‐product] Xenopus laevis (African clawed frog) 409 100.00% Xenopus tropicalis (Western clawed frog) dhh ARP45230_T100 A0JM37_XENTR Dhh protein (Silurana tropicalis) 396 92.00% hedgehog protein B (Desert hedgehog protein 2) (DHH‐2) (Hedgehog protein 4) (X‐ HH4) [Cleaved into: Desert hedgehog protein B N‐product; Desert hedgehog protein B C‐ dhh ARP45230_T100 DHHB_XENLA product] Xenopus laevis (African clawed frog) 398 92.00%

Desert hedgehog protein A (Cephalic hedgehog protein) (Desert hedgehog protein 1) (DHH‐1) (X‐CHH) [Cleaved into: Desert hedgehog protein A N‐product; Desert dhh ARP45230_T100 DHHA_XENLA hedgehog protein A C‐product] Xenopus laevis (African clawed frog) 396 92.00%

Sonic hedgehog protein (VHH‐1) (X‐SHH) [Cleaved into: protein N‐ dhh ARP45230_T100 SHH_XENLA product; Sonic hedgehog protein C‐product] Xenopus laevis (African clawed frog) 444 85.00% Xenopus tropicalis (Western clawed frog) AVARP13056_T100 Q28H43_XENTR RAB3A, member RAS oncogene family (Silurana tropicalis) 220 86.00% AVARP13056_T100 Q5U507_XENLA Rab3a‐prov protein Xenopus laevis (African clawed frog) 220 80.00% ORF Names:TVAG_206040 EMBL EAY13436.1OrganismTrichomonas vaginalis ARP40418_T100 Q68A88_XENLA 20S proteasome alpha6 subunit (Fragment) Xenopus laevis (African clawed frog) 261 100.00% ORF Names:TVAG_206040 EMBL EAY13436.1OrganismTrichomonas vaginalis ARP40418_T100 Q5XGP0_XENLA Putative uncharacterized protein Xenopus laevis (African clawed frog) 261 100.00% ORF Names:TVAG_206040 EMBL EAY13436.1OrganismTrichomonas vaginalis ARP40418_T100 Q58E21_XENLA MGC115143 protein Xenopus laevis (African clawed frog) 261 100.00% ORF Names:TVAG_206040 EMBL EAY13436.1OrganismTrichomonas Proteasome (Prosome macropain) subunit Xenopus tropicalis (Western clawed frog) vaginalis ARP40418_T100 Q28FS5_XENTR alpha type 1 (Silurana tropicalis) 261 92.00% ORF Names:TVAG_206040 EMBL EAY13436.1OrganismTrichomonas Xenopus tropicalis (Western clawed frog) vaginalis ARP40418_T100 Q642N1_XENTR MGC90008 protein (Silurana tropicalis) 261 85.00% Zinc finger protein 830 (Coiled‐coil domain‐ Xenopus tropicalis (Western clawed frog) ZNF830 ARP36111_P050 ZN830_XENTR containing protein 16) (Silurana tropicalis) 357 85.00% Zinc finger protein 830 (Coiled‐coil domain‐ ZNF830 ARP36111_P050 ZN830_XENLA containing protein 16) Xenopus laevis (African clawed frog) 356 85.00% vax2 ARP36999_P050 VAX1B_XENLA Ventral anterior homeobox 1b Xenopus laevis (African clawed frog) 287 100.00% vax2 ARP36999_P050 VAX1A_XENLA Ventral anterior homeobox 1a Xenopus laevis (African clawed frog) 295 100.00% vax2 ARP36999_P050 B7ZR64_XENLA Vax2 protein Xenopus laevis (African clawed frog) 302 78.00% Ventral anterior homeobox 2b (Ventral vax2 ARP36999_P050 VAX2B_XENLA anterior homeobox 3) Xenopus laevis (African clawed frog) 294 78.00% vax2 ARP36999_P050 VAX2A_XENLA Ventral anterior homeobox 2a (Xvax2) Xenopus laevis (African clawed frog) 302 78.00% ARP39524_P050 Q91840_XENLA beta Xenopus laevis (African clawed frog) 412 92.00% ARP39524_P050 Q91613_XENLA XRXR beta Xenopus laevis (African clawed frog) 452 92.00% ARP39524_P050 Q6INZ0_XENLA Rxrb protein Xenopus laevis (African clawed frog) 449 92.00% ARP39524_P050 Q6GPF8_XENLA Rxrb‐A‐prov protein (Fragment) Xenopus laevis (African clawed frog) 451 92.00% ARP39524_P050 Q4FZW9_XENLA Rxrb‐A‐prov protein (Fragment) Xenopus laevis (African clawed frog) 458 92.00% ARP39524_P050 Q2VPP3_XENLA Rxrb‐a protein (Fragment) Xenopus laevis (African clawed frog) 458 92.00% RXR‐beta (Retinoid X Xenopus tropicalis (Western clawed frog) ARP39524_P050 Q28CI3_XENTR receptor beta) (Silurana tropicalis) 449 92.00% ARP39524_P050 B7FEW3_XENLA Rxrb‐a protein (Fragment) Xenopus laevis (African clawed frog) 445 92.00% Xenopus tropicalis (Western clawed frog) ARP39524_P050 B3DLT9_XENTR Rxrb protein (Silurana tropicalis) 412 92.00% Xenopus tropicalis (Western clawed frog) ARP39524_P050 Q0IIU2_XENTR LOC779621 protein (Fragment) (Silurana tropicalis) 452 92.00% Retinoic acid receptor RXR‐alpha (Nuclear receptor subfamily 2 group B member 1) ARP39524_P050 RXRA_XENLA (Retinoid X receptor alpha) Xenopus laevis (African clawed frog) 488 92.00% ARP39524_P050 Q5HZR5_XENLA LOC496325 protein Xenopus laevis (African clawed frog) 470 84.00% ARP39524_P050 Q4KLS2_XENLA MGC115510 protein Xenopus laevis (African clawed frog) 471 84.00% Retinoic acid receptor RXR‐gamma (Nuclear receptor subfamily 2 group B member 3) ARP39524_P050 RXRG_XENLA (Retinoid X receptor gamma) Xenopus laevis (African clawed frog) 470 84.00% Amot protein (Putative uncharacterized Xenopus tropicalis (Western clawed frog) AMOT ARP34660_P050 B0BLZ0_XENTR protein) (Fragment) (Silurana tropicalis) 745 84.00%

ORF Names:v1g80463OrganismNematostell a vectensis (Starlet sea anemone) ARP40234_T100 Q7ZYN0_XENLA Rbms1‐prov protein Xenopus laevis (African clawed frog) 374 100.00% ORF Names:v1g80463OrganismNematostell Xenopus tropicalis (Western clawed frog) a vectensis (Starlet sea anemone) ARP40234_T100 Q0IIS2_XENTR LOC100036596 protein (Silurana tropicalis) 406 100.00%

ORF Names:v1g80463OrganismNematostell Xenopus tropicalis (Western clawed frog) a vectensis (Starlet sea anemone) ARP40234_T100 B4F6H4_XENTR LOC100036596 protein (Silurana tropicalis) 399 100.00% Xenopus tropicalis (Western clawed frog) march5l ARP43233_P050 B1H1A5_XENTR March5 protein (Silurana tropicalis) 283 100.00% E3 ubiquitin‐protein ligase MARCH5 (EC 6.3.2.‐ ) (Membrane‐associated RING finger protein 5) (Membrane‐associated RING‐CH protein V) march5l ARP43233_P050 MARH5_XENLA (MARCH‐V) Xenopus laevis (African clawed frog) 283 100.00% Alas1 ARP54346_P050 Q6DKE7_XENLA MGC81838 protein Xenopus laevis (African clawed frog) 623 84.00% Alas1 ARP54346_P050 Q6PAZ6_XENLA MGC68700 protein Xenopus laevis (African clawed frog) 621 84.00% Xenopus tropicalis (Western clawed frog) Alas1 ARP54346_P050 Q66JC7_XENTR MGC79710 protein (Silurana tropicalis) 628 84.00% Xenopus tropicalis (Western clawed frog) Alas1 ARP54346_P050 Q28HS9_XENTR Aminolevulinate, delta‐, synthase 1 (Silurana tropicalis) 628 84.00%

ORF Names:v1g86952OrganismNematostell a vectensis (Starlet sea anemone) ARP38984_T100 Q5U4S3_XENLA LOC495449 protein Xenopus laevis (African clawed frog) 148 100.00%

ORF Names:v1g86952OrganismNematostell Xenopus tropicalis (Western clawed frog) a vectensis (Starlet sea anemone) ARP38984_T100 A0JP90_XENTR Mafk protein (Silurana tropicalis) 156 100.00%

ORF Names:v1g86952OrganismNematostell a vectensis (Starlet sea anemone) ARP38984_T100 Q9PUA5_XENLA BZIP transcription factor L‐Maf Xenopus laevis (African clawed frog) 267 100.00%

ORF Names:v1g86952OrganismNematostell a vectensis (Starlet sea anemone) ARP38984_T100 B7ZRB4_XENLA BZIP transcription factor L‐Maf Xenopus laevis (African clawed frog) 267 100.00%

ORF Names:v1g86952OrganismNematostell Xenopus tropicalis (Western clawed frog) a vectensis (Starlet sea anemone) ARP38984_T100 A4IHY9_XENTR Leucine zipper transcription factor (Silurana tropicalis) 267 100.00% ORF Names:v1g86952OrganismNematostell Xenopus tropicalis (Western clawed frog) a vectensis (Starlet sea anemone) ARP38984_T100 MAF_XENTR Transcription factor Maf (Silurana tropicalis) 352 92.00%

ORF Names:v1g86952OrganismNematostell Xenopus tropicalis (Western clawed frog) a vectensis (Starlet sea anemone) ARP38984_T100 MAFB_XENTR Transcription factor MafB (Maf‐B) (XMafB) (Silurana tropicalis) 316 92.00%

ORF Names:v1g86952OrganismNematostell a vectensis (Starlet sea anemone) ARP38984_T100 MAFB_XENLA Transcription factor MafB (Maf‐B) (XMafB) Xenopus laevis (African clawed frog) 313 92.00%

ORF Names:v1g86952OrganismNematostell Xenopus tropicalis (Western clawed frog) a vectensis (Starlet sea anemone) ARP38984_T100 MAFA_XENTR Transcription factor MafA (Silurana tropicalis) 289 92.00%

ORF Names:v1g86952OrganismNematostell Xenopus tropicalis (Western clawed frog) a vectensis (Starlet sea anemone) ARP38984_T100 Q4U1T9_XENTR Leucine zipper transcription factor (Silurana tropicalis) 267 92.00% Nuclear receptor subfamily 2 group E member 1 (Nuclear receptor TLX) (Protein tailless NR2E1 ARP33422_P050 NR2E1_XENLA homolog) (Tll) (xTLL) Xenopus laevis (African clawed frog) 386 92.00% aes ARP32323_P050 Q6P9I8_XENLA Aes protein Xenopus laevis (African clawed frog) 197 100.00% Amino‐terminal enhancer of split (Transducin‐ like enhancer of split 4 homolog of Drosophila Xenopus tropicalis (Western clawed frog) aes ARP32323_P050 Q28C95_XENTR E(Spl)) (Silurana tropicalis) 198 100.00% Xenopus tropicalis (Western clawed frog) aes ARP32323_P050 A4IIB2_XENTR AES (Aes protein) (Silurana tropicalis) 197 100.00% Amino‐terminal enhancer of split (Amino aes ARP32323_P050 AES_XENLA enhancer of split) (Protein GRG) Xenopus laevis (African clawed frog) 197 100.00%

ORF Names:TRIADDRAFT_53474 EMBL EDV27607.1OrganismTrichoplax adhaerens (Trichoplax reptans) P100990_T100 Q63ZH4_XENLA LOC494830 protein Xenopus laevis (African clawed frog) 316 92.00%

ORF Names:TRIADDRAFT_53474 EMBL EDV27607.1OrganismTrichoplax General transcription factor IIBgeneral Xenopus tropicalis (Western clawed frog) adhaerens (Trichoplax reptans) P100990_T100 Q28G23_XENTR transcription factor IIB (Silurana tropicalis) 316 92.00%

ORF Names:TRIADDRAFT_53474 EMBL EDV27607.1OrganismTrichoplax Transcription initiation factor IIB (General adhaerens (Trichoplax reptans) P100990_T100 TF2B_XENLA transcription factor TFIIB) Xenopus laevis (African clawed frog) 316 92.00% Dcp2 decapping enzyme homolog (S. Xenopus tropicalis (Western clawed frog) ARP41149_P050 Q28DQ4_XENTR cerevisiae) (Silurana tropicalis) 422 78.00% ORF Names:PANDA_019111 EMBL EFB21056.1OrganismAiluropoda Xenopus tropicalis (Western clawed frog) melanoleuca (Giant panda) ARP43534_T100 Q5M8X7_XENTR Hypothetical LOC496662 (Silurana tropicalis) 429 78.00% ORF Names:PANDA_019111 EMBL EFB21056.1OrganismAiluropoda Xenopus tropicalis (Western clawed frog) melanoleuca (Giant panda) ARP43534_T100 Q28I58_XENTR Aminoadipate aminotransferase (Silurana tropicalis) 429 78.00% ORF Names:CpipJ_CPIJ012025 EMBL EDS36830.1OrganismCulex quinquefasciatus (Southern house Xenopus tropicalis (Western clawed frog) mosquito) (Culex pungens) ARP40542_P050 Q6P8A5_XENTR PRP4 pre‐mRNA processing factor 4 homolog (Silurana tropicalis) 507 100.00% ORF Names:CpipJ_CPIJ012025 EMBL EDS36830.1OrganismCulex quinquefasciatus (Southern house mosquito) (Culex pungens) ARP40542_P050 Q66J65_XENLA MGC81780 protein Xenopus laevis (African clawed frog) 483 100.00% ORF Names:GSPATT00031505001 EMBL Novel myeloid/lymphoid or mixed‐linkage CAK61274.1OrganismParamecium leukemia (Trithorax homolog, Drosophila) Xenopus tropicalis (Western clawed frog) tetraurelia ARP39281_P050 Q28D91_XENTR family protein (Fragment) (Silurana tropicalis) 462 81.00% ORF Names:GSPATT00031505001 EMBL CAK61274.1OrganismParamecium Xenopus tropicalis (Western clawed frog) tetraurelia ARP39281_P050 Q0D2F6_XENTR Mllt6 protein (Silurana tropicalis) 465 81.00% ORF Names:GSPATT00031505001 EMBL CAK61274.1OrganismParamecium Xenopus tropicalis (Western clawed frog) tetraurelia ARP39281_P050 A8WGE2_XENTR Putative uncharacterized protein (Silurana tropicalis) 893 81.00% hip2 ARP43048_T100 Q8AVM8_XENLA Ube2k protein Xenopus laevis (African clawed frog) 200 100.00% Ubiquitin‐conjugating enzyme E2K (UBC1 Xenopus tropicalis (Western clawed frog) hip2 ARP43048_T100 Q6GL28_XENTR homolog) (Silurana tropicalis) 200 100.00% Xenopus tropicalis (Western clawed frog) hip2 ARP43048_T100 B0JZQ9_XENTR LOC100145219 protein (Silurana tropicalis) 200 100.00% tmem93 ARP44679_P050 A9UMP4_XENLA LOC100137696 protein Xenopus laevis (African clawed frog) 110 92.00% Xenopus tropicalis (Western clawed frog) tmem93 ARP44679_P050 TMM93_XENTR Transmembrane protein 93 (Silurana tropicalis) 110 92.00% tmem93 ARP44679_P050 TMM93_XENLA Transmembrane protein 93 Xenopus laevis (African clawed frog) 110 92.00% AHRR ARP39438_P050 B2KSJ4_XENLA Aryl hydrocarbon receptor repressor Xenopus laevis (African clawed frog) 754 90.00% ORF Names:GSPATT00021699001 EMBL CAK88531.1OrganismParamecium tetraurelia ARP48149_P050 Q6GQF9_XENLA Ak1a protein Xenopus laevis (African clawed frog) 194 92.00% ORF Names:GSPATT00021699001 EMBL CAK88531.1OrganismParamecium Xenopus tropicalis (Western clawed frog) tetraurelia ARP48149_P050 Q6DFN0_XENTR Adenylate kinase 1 (Silurana tropicalis) 194 92.00% ORF Names:GSPATT00021699001 EMBL CAK88531.1OrganismParamecium tetraurelia ARP48149_P050 Q66J33_XENLA Ak1b protein Xenopus laevis (African clawed frog) 212 92.00% Rbmx ARP40257_P050 Q6IRQ4_XENLA MGC82187 protein Xenopus laevis (African clawed frog) 370 85.00% Xenopus tropicalis (Western clawed frog) Rbmx ARP40257_P050 A9UMT9_XENTR LOC100135403 protein (Fragment) (Silurana tropicalis) 375 85.00% Xenopus tropicalis (Western clawed frog) me3 ARP48511_P050 B1H2E0_XENTR LOC100145399 protein (Silurana tropicalis) 574 100.00% me3 ARP48511_P050 Q5U525_XENLA LOC495390 protein Xenopus laevis (African clawed frog) 613 85.00% Xenopus tropicalis (Western clawed frog) me3 ARP48511_P050 A9JRL5_XENTR LOC100135099 protein (Silurana tropicalis) 613 85.00% SAP30 ARP38393_T100 Q66GV8_XENLA MGC99111 protein Xenopus laevis (African clawed frog) 194 85.00% Xenopus tropicalis (Western clawed frog) SAP30 ARP38393_T100 Q28IA6_XENTR Sin3‐associated polypeptide, 30kDa (Silurana tropicalis) 195 85.00% Xenopus tropicalis (Western clawed frog) SAP30 ARP38393_T100 B7ZSN0_XENTR Sin3‐associated polypeptide, 30kDa (Silurana tropicalis) 194 85.00% Xenopus tropicalis (Western clawed frog) SAP30 ARP38393_T100 B5DDX8_XENTR Putative uncharacterized protein (Silurana tropicalis) 152 85.00% SAP30 ARP38393_T100 Q7ZXP2_XENLA Sap30l‐a protein Xenopus laevis (African clawed frog) 174 78.00% Xenopus tropicalis (Western clawed frog) SAP30 ARP38393_T100 B1WAV0_XENTR Sap30l protein (Silurana tropicalis) 181 78.00%

Histone deacetylase complex subunit SAP30L (Sin3 corepressor complex subunit SAP30L) Xenopus tropicalis (Western clawed frog) SAP30 ARP38393_T100 SP30L_XENTR (Sin3‐associated protein p30‐like) (Silurana tropicalis) 181 78.00%

Histone deacetylase complex subunit SAP30L‐ B (Sin3 corepressor complex subunit SAP30L‐ SAP30 ARP38393_T100 S30LB_XENLA B) (Sin3‐associated protein p30‐like B) Xenopus laevis (African clawed frog) 181 78.00%

Histone deacetylase complex subunit SAP30L‐ A (Sin3 corepressor complex subunit SAP30L‐ SAP30 ARP38393_T100 S30LA_XENLA A) (Sin3‐associated protein p30‐like A) Xenopus laevis (African clawed frog) 181 78.00% ARP49773_P050 TM135_XENLA Transmembrane protein 135 Xenopus laevis (African clawed frog) 453 85.00% General transcription factor II‐I repeat domain‐ containing protein 1 (Binding factor for early enhancer) (BEN) (XBEN) (GTF2I repeat domain‐ containing protein 1) (Williams‐Beuren syndrome critical region 11‐like protein) Gtf2ird1 ARP39254_T100 GT2D1_XENLA (XWBSCR11) Xenopus laevis (African clawed frog) 993 92.00% Xenopus tropicalis (Western clawed frog) ABHDD ARP50138_P050 A9JTX5_XENTR LOC100127876 protein (Silurana tropicalis) 336 100.00% ABHDD ARP50138_P050 A4IFW9_XENLA LOC100049138 protein Xenopus laevis (African clawed frog) 336 100.00% Abhydrolase domain‐containing protein 13 ABHDD ARP50138_P050 ABHDD_XENLA (EC 3.‐.‐.‐) Xenopus laevis (African clawed frog) 336 100.00% Xenopus tropicalis (Western clawed frog) ARP35338_T100 A4IIK0_XENTR Gabrb3 protein (Silurana tropicalis) 475 92.00% Xenopus tropicalis (Western clawed frog) ARP35338_T100 A4IIN3_XENTR LOC100125027 protein (Silurana tropicalis) 474 85.00% E3 ubiquitin‐protein ligase MARCH8 (EC 6.3.2.‐ ORF Names:CH211‐42I9.7‐001 EMBL ) (Membrane‐associated RING finger protein CAX14354.1OrganismDanio rerio 8) (Membrane‐associated RING‐CH protein Xenopus tropicalis (Western clawed frog) (Zebrafish) (Brachydanio rerio) ARP43401_P050 MARH8_XENTR VIII) (MARCH‐VIII) (Silurana tropicalis) 264 100.00% E3 ubiquitin‐protein ligase MARCH8 (EC 6.3.2.‐ ORF Names:CH211‐42I9.7‐001 EMBL ) (Membrane‐associated RING finger protein CAX14354.1OrganismDanio rerio 8) (Membrane‐associated RING‐CH protein (Zebrafish) (Brachydanio rerio) ARP43401_P050 MARH8_XENLA VIII) (MARCH‐VIII) Xenopus laevis (African clawed frog) 264 100.00% Xenopus tropicalis (Western clawed frog) STK3 ARP48701_T100 A0JP92_XENTR LOC100036637 protein (Silurana tropicalis) 493 92.00% Serine/threonine‐protein kinase 3 (EC STK3 ARP48701_T100 STK3_XENLA 2.7.11.1) Xenopus laevis (African clawed frog) 493 85.00% ARP35467_P050 O57662_XENLA Potassium channel xKv4.3 Xenopus laevis (African clawed frog) 659 100.00% kcnd3 ARP35467_P050 B7ZRQ9_XENLA Kcnd3‐A protein Xenopus laevis (African clawed frog) 653 100.00% Xenopus tropicalis (Western clawed frog) kcnd3 ARP35467_P050 A4IIK9_XENTR LOC100125015 protein (Silurana tropicalis) 653 100.00% WD repeat domain phosphoinositide‐ interacting protein 3 (WIPI‐3) (WD repeat‐ containing protein 45‐like) (WDR45‐like Xenopus tropicalis (Western clawed frog) wdr45l ARP34588_P050 WIPI3_XENTR protein) (Silurana tropicalis) 344 100.00% WD repeat domain phosphoinositide‐ interacting protein 3 (WIPI‐3) (WD repeat‐ containing protein 45‐like) (WDR45‐like wdr45l ARP34588_P050 WIPI3_XENLA protein) Xenopus laevis (African clawed frog) 344 100.00% Sonic hedgehog protein (VHH‐1) (X‐SHH) [Cleaved into: Sonic hedgehog protein N‐ SHH ARP44235_P050 SHH_XENLA product; Sonic hedgehog protein C‐product] Xenopus laevis (African clawed frog) 444 100.00% Xenopus tropicalis (Western clawed frog) ARP39949_T100 Q28EA5_XENTR Novel zinc finger protein (Silurana tropicalis) 624 83.00% Xenopus tropicalis (Western clawed frog) znf3 ARP39949_T100 B3DLT7_XENTR Putative uncharacterized protein (Silurana tropicalis) 403 78.00% Xenopus tropicalis (Western clawed frog) znf3 ARP39949_T100 B0JZ14_XENTR LOC100145140 protein (Silurana tropicalis) 344 83.00% Xenopus tropicalis (Western clawed frog) znf3 ARP39949_T100 ZN865_XENTR Zinc finger protein 865 (Silurana tropicalis) 942 81.00% SLC6A1 ARP43834_P050 Q2KM82_XENLA GABA neurotransmitter transporter 1 Xenopus laevis (African clawed frog) 599 78.00% SLC6A1 ARP43834_P050 B7ZRL8_XENLA GABA neurotransmitter transporter 1 Xenopus laevis (African clawed frog) 599 78.00% Xenopus tropicalis (Western clawed frog) SLC6A1 ARP43834_P050 A8WGF5_XENTR LOC100127682 protein (Silurana tropicalis) 599 78.00% ORF Names:LbrM09_V2.0160 EMBL CAM41755.1OrganismLeishmania Iroquois‐class homeodomain protein irx‐5 braziliensis ARP40093_P050 IRX5_XENLA (Iroquois homeobox protein 5) Xenopus laevis (African clawed frog) 474 90.00% Xenopus tropicalis (Western clawed frog) TMEM231 ARP45005_T100 B0JYY1_XENTR LOC100145127 protein (Silurana tropicalis) 312 78.00% ARP33538_T100 Q6GQ43_XENLA MGC80357 protein Xenopus laevis (African clawed frog) 722 100.00% ARP33538_T100 Q6DD15_XENLA Pik3r2‐prov protein Xenopus laevis (African clawed frog) 457 100.00% ARP33538_T100 Q66IU1_XENLA MGC84470 protein Xenopus laevis (African clawed frog) 461 100.00% Phosphoinositide‐3‐kinase, regulatory Xenopus tropicalis (Western clawed frog) ARP33538_T100 Q28IS1_XENTR subunit, polypeptide 3 (P55, gamma) (Silurana tropicalis) 461 100.00% ARP33538_T100 B7ZRE0_XENLA MGC80357 protein Xenopus laevis (African clawed frog) 722 100.00% ARP33538_T100 B7ZRD8_XENLA Phosphoinositide‐3‐kinase Xenopus laevis (African clawed frog) 722 100.00% ARP33538_T100 B3DLK8_XENLA Putative uncharacterized protein Xenopus laevis (African clawed frog) 463 100.00% Xenopus tropicalis (Western clawed frog) ARP33538_T100 A4IIS0_XENTR Putative uncharacterized protein (Fragment) (Silurana tropicalis) 297 100.00%

ARP33538_T100 A1L2M1_XENLA Putative uncharacterized protein (Fragment) Xenopus laevis (African clawed frog) 481 100.00% Phosphatidylinositol 3‐kinase regulatory subunit alpha (PI3‐kinase regulatory subunit alpha) (PI3K regulatory subunit alpha) (PtdIns‐ 3‐kinase regulatory subunit alpha) (Phosphatidylinositol 3‐kinase 85 kDa regulatory subunit alpha) (PI3‐kinase subunit p85‐alpha) (PtdIns‐3‐kinase regulatory subunit ARP33538_T100 P85AA_XENLA p85‐alpha) Xenopus laevis (African clawed frog) 722 100.00% Stress‐induced‐phosphoprotein 1 Xenopus tropicalis (Western clawed frog) ARP46164_T100 Q6P302_XENTR (Hsp70/Hsp90‐organizing protein) (Silurana tropicalis) 543 78.00% CCNT1 AVARP03021_P050 Q642S5_XENLA MGC81210 protein Xenopus laevis (African clawed frog) 647 91.00% Xenopus tropicalis (Western clawed frog) CCNT1 AVARP03021_P050 B3DM77_XENTR Ccnt1 protein (Silurana tropicalis) 236 100.00% Xenopus tropicalis (Western clawed frog) ARP34680_T100 Q6DEU6_XENTR Midline 1 (Opitz/BBB syndrome) (Silurana tropicalis) 668 100.00% ARP34680_T100 D8WX02_XENLA Midline 1 Xenopus laevis (African clawed frog) 668 100.00% lhx4 ARP33644_P050 B7ZPU9_XENLA Xlim‐3 protein Xenopus laevis (African clawed frog) 395 85.00%

LIM/homeobox protein Lhx3 (LIM homeobox lhx4 ARP33644_P050 LHX3_XENLA protein 3) (Homeobox protein LIM‐3) (xLIM‐3) Xenopus laevis (African clawed frog) 395 85.00% LOC100127802 ARP46894_P050 Q6INK2_XENLA LOC397717 protein (Fragment) Xenopus laevis (African clawed frog) 278 92.00% LOC100127802 ARP46894_P050 Q3B899_XENLA LOC397717 protein (Fragment) Xenopus laevis (African clawed frog) 286 92.00%

LOC100127802 ARP46894_P050 B7ZP70_XENLA Farnesyl cysteine carboxyl methyltransferase Xenopus laevis (African clawed frog) 288 92.00% Xenopus tropicalis (Western clawed frog) LOC100127802 ARP46894_P050 A9JTN3_XENTR LOC100127802 protein (Fragment) (Silurana tropicalis) 258 92.00%

Protein‐S‐isoprenylcysteine O‐ methyltransferase (EC 2.1.1.100) (Farnesyl cysteine carboxyl methyltransferase) (FCMT) (Isoprenylcysteine carboxylmethyltransferase) (Prenylated protein carboxyl methyltransferase) (PPMT) (Prenylcysteine LOC100127802 ARP46894_P050 ICMT_XENLA carboxyl methyltransferase) (pcCMT) Xenopus laevis (African clawed frog) 288 92.00% ORF Names:PANDA_001480 EMBL EFB19706.1OrganismAiluropoda melanoleuca (Giant panda) P100852_P050 C0J6M9_XENLA MEF2A alpha 1b isoform Xenopus laevis (African clawed frog) 406 84.00% ORF Names:PANDA_001480 EMBL EFB19706.1OrganismAiluropoda melanoleuca (Giant panda) P100852_P050 C0J6M6_XENLA MEF2A alpha 2 isoform Xenopus laevis (African clawed frog) 477 84.00% ORF Names:PANDA_001480 EMBL EFB19706.1OrganismAiluropoda melanoleuca (Giant panda) P100852_P050 C0J6M5_XENLA MEF2A alpha 12b isoform Xenopus laevis (African clawed frog) 448 84.00% ORF Names:PANDA_001480 EMBL Myocyte‐specific enhancer factor 2A homolog EFB19706.1OrganismAiluropoda (XMEF2A1) (xMEF2A) (Serum response factor‐ melanoleuca (Giant panda) P100852_P050 MEF2A_XENLA like protein 2) (SL‐2) Xenopus laevis (African clawed frog) 516 84.00% ORF Names:PANDA_001480 EMBL EFB19706.1OrganismAiluropoda melanoleuca (Giant panda) P100852_P050 Q9PSD8_XENLA DNA binding protein Xenopus laevis (African clawed frog) 382 84.00% tRNA (guanine‐N(7)‐)‐methyltransferase subunit WDR4 (WD repeat‐containing protein Xenopus tropicalis (Western clawed frog) WDR4 ARP41320_P050 WDR4_XENTR 4) (Silurana tropicalis) 396 84.00% tRNA (guanine‐N(7)‐)‐methyltransferase subunit WDR4 (WD repeat‐containing protein WDR4 ARP41320_P050 WDR4_XENLA 4) Xenopus laevis (African clawed frog) 396 84.00% ORF Names:GSPATT00017196001 EMBL CAK82824.1OrganismParamecium Xenopus tropicalis (Western clawed frog) tetraurelia ARP46141_T100 Q66JH4_XENTR MGC79544 protein (Silurana tropicalis) 105 100.00% ORF Names:GSPATT00017196001 EMBL CAK82824.1OrganismParamecium tetraurelia ARP46141_T100 A8E5Z6_XENLA LOC100126631 protein (Fragment) Xenopus laevis (African clawed frog) 197 100.00% ORF Names:GSPATT00017196001 EMBL CAK82824.1OrganismParamecium tetraurelia ARP46141_T100 Q7SZ26_XENLA Ppib‐prov protein Xenopus laevis (African clawed frog) 216 92.00% ORF Names:GSPATT00017196001 EMBL CAK82824.1OrganismParamecium Xenopus tropicalis (Western clawed frog) tetraurelia ARP46141_T100 Q28G13_XENTR Peptidylprolyl isomerase B (Cyclophilin B) (Silurana tropicalis) 208 92.00% ORF Names:GSPATT00017196001 EMBL CAK82824.1OrganismParamecium tetraurelia ARP46141_T100 Q7SZ12_XENLA CypA protein (Fragment) Xenopus laevis (African clawed frog) 193 78.00% ORF Names:GSPATT00017196001 EMBL CAK82824.1OrganismParamecium tetraurelia ARP46141_T100 Q6NUH4_XENLA CypA protein (Fragment) Xenopus laevis (African clawed frog) 192 78.00% ORF Names:GSPATT00017196001 EMBL CAK82824.1OrganismParamecium tetraurelia ARP46141_T100 Q6DTN6_XENLA Cyclophilin A (CypA protein) Xenopus laevis (African clawed frog) 164 78.00% ORF Names:GSPATT00017196001 EMBL CAK82824.1OrganismParamecium tetraurelia ARP46141_T100 Q8AVP8_XENLA Cyp‐7‐prov protein Xenopus laevis (African clawed frog) 164 78.00% ORF Names:GSPATT00017196001 EMBL CAK82824.1OrganismParamecium Peptidylprolyl cis‐trans isomerase (EC 5.2.1.8) tetraurelia ARP46141_T100 Q70YG6_XENLA (Fragment) Xenopus laevis (African clawed frog) 157 78.00% Zinc finger protein ubi‐d4 A (Apoptosis response zinc finger protein A) (Protein ARP33222_P050 REQUA_XENLA requiem A) (xReq A) Xenopus laevis (African clawed frog) 388 85.00% dpf2 ARP33222_P050 Q6IRM6_XENLA LOC397786 protein Xenopus laevis (African clawed frog) 387 85.00% Zinc finger protein ubi‐d4 B (Apoptosis response zinc finger protein B) (Protein dpf2 ARP33222_P050 REQUB_XENLA requiem B) (xReq B) (Fragment) Xenopus laevis (African clawed frog) 366 85.00% D4, zinc and double PHD fingers family 2 Xenopus tropicalis (Western clawed frog) dpf2 ARP33222_P050 Q28IH5_XENTR (Fragment) (Silurana tropicalis) 298 78.00% SUPT3H ARP30038_T100 Q6AX62_XENLA MGC84129 protein Xenopus laevis (African clawed frog) 350 83.00% Xenopus tropicalis (Western clawed frog) ZNF692 ARP50446_P050 ZN574_XENTR Zinc finger protein 574 (Silurana tropicalis) 857 90.00% ZNF692 ARP50446_P050 Q6AX11_XENLA Znf420 protein Xenopus laevis (African clawed frog) 980 78.00% Xenopus tropicalis (Western clawed frog) ZNF692 ARP50446_P050 B1H2B7_XENTR Putative uncharacterized protein (Silurana tropicalis) 419 90.00% Xenopus tropicalis (Western clawed frog) ZNF692 ARP50446_P050 B0BMG1_XENTR LOC779587 protein (Silurana tropicalis) 438 78.00% Edf1 ARP35695_P050 Q3B8F0_XENLA MGC131240 protein Xenopus laevis (African clawed frog) 148 92.00% Xenopus tropicalis (Western clawed frog) Edf1 ARP35695_P050 Q28IW0_XENTR Endothelial differentiation‐related factor 1 (Silurana tropicalis) 148 92.00% Endothelial differentiation‐related factor 1 Edf1 ARP35695_P050 EDF1_XENLA homolog (EDF‐1) Xenopus laevis (African clawed frog) 147 92.00% Xenopus tropicalis (Western clawed frog) ARP38176_T100 Q68FA6_XENTR Paired‐like homeodomain 1 (Silurana tropicalis) 305 78.00% Pituitary homeobox gene 1 paired‐ likehomeodomain transcription factor (Pitx1 pitx1 ARP38176_T100 B7ZPG5_XENLA protein) Xenopus laevis (African clawed frog) 305 78.00%

Pituitary homeobox 1 (Homeobox protein PITX1) (X‐PITX‐1) (xPitx1) (Paired‐like pitx1 ARP38176_T100 PITX1_XENLA homeodomain transcription factor 1) Xenopus laevis (African clawed frog) 305 78.00% SFXN3 ARP49989_P050 Q7ZY10_XENLA Xm278‐prov protein Xenopus laevis (African clawed frog) 322 92.00% Xenopus tropicalis (Western clawed frog) SFXN3 ARP49989_P050 B5DEV1_XENTR Putative uncharacterized protein (Silurana tropicalis) 322 78.00% Xenopus tropicalis (Western clawed frog) LOC100036700 ARP41630_P050 A1A5H3_XENTR LOC100036700 protein (Silurana tropicalis) 775 85.00% Xenopus tropicalis (Western clawed frog) FAM3C ARP44904_P050 FAM3C_XENTR Protein FAM3C (Silurana tropicalis) 229 100.00% FAM3C ARP44904_P050 FAM3C_XENLA Protein FAM3C Xenopus laevis (African clawed frog) 229 100.00% FAM3C ARP44904_P050 Q801R5_XENLA MGC52899 protein Xenopus laevis (African clawed frog) 216 92.00% FAM3C ARP44904_P050 Q7T0W3_XENLA MGC68927 protein Xenopus laevis (African clawed frog) 226 92.00% Family with sequence similarity 3, member D Xenopus tropicalis (Western clawed frog) FAM3C ARP44904_P050 Q68FA3_XENTR (Oit1 protein) (Silurana tropicalis) 226 92.00% FAM3C ARP44904_P050 Q7ZYE0_XENLA Fam3a‐prov protein Xenopus laevis (African clawed frog) 230 85.00% Fam3a protein (Family with sequence Xenopus tropicalis (Western clawed frog) FAM3C ARP44904_P050 Q68F80_XENTR similarity 3, member A) (Silurana tropicalis) 230 85.00% FAM3C ARP44904_P050 Q32NN5_XENLA MGC131013 protein Xenopus laevis (African clawed frog) 230 85.00% Prp8 ARP40649_P050 Q7ZX28_XENLA Prp‐8‐prov protein Xenopus laevis (African clawed frog) 2335 100.00% ARP46539_P050 Q5XGQ2_XENLA LOC495169 protein Xenopus laevis (African clawed frog) 637 100.00% Ectoderm neural cortex related‐3 (Encr‐3 ENC1 ARP34184_P050 Q7ZUA7_XENLA protein) Xenopus laevis (African clawed frog) 589 85.00% ARP43858_P050 Q6INL0_XENLA LOC443574 protein (Fragment) Xenopus laevis (African clawed frog) 676 85.00% ARP43858_P050 Q52KY7_XENLA LOC443574 protein Xenopus laevis (African clawed frog) 670 85.00% Solute carrier family 25 (Mitochondrial carrier, Xenopus tropicalis (Western clawed frog) ARP43858_P050 Q28EN1_XENTR Aralar), member 12 (Silurana tropicalis) 495 85.00% Xenopus tropicalis (Western clawed frog) ARP43858_P050 B2GUQ3_XENTR Slc25a12 protein (Silurana tropicalis) 668 85.00% Flap endonuclease 1 (FEN‐1) (EC 3.1.‐.‐) (Flap Xenopus tropicalis (Western clawed frog) FEN1 ARP46097_T100 FEN1_XENTR structure‐specific endonuclease 1) (Silurana tropicalis) 382 92.00% Flap endonuclease 1‐B (FEN‐1‐B) (EC 3.1.‐.‐) (Flap structure‐specific endonuclease 1‐B) FEN1 ARP46097_T100 FEN1B_XENLA (xFEN‐1b) Xenopus laevis (African clawed frog) 382 92.00% Flap endonuclease 1‐A (FEN‐1‐A) (EC 3.1.‐.‐) (Flap structure‐specific endonuclease 1‐A) FEN1 ARP46097_T100 FEN1A_XENLA (xFEN‐1a) Xenopus laevis (African clawed frog) 382 92.00% Xenopus tropicalis (Western clawed frog) ARP49475_P050 CO024_XENTR UPF0480 protein C15orf24 homolog (Silurana tropicalis) 237 100.00% Xenopus tropicalis (Western clawed frog) prdm8b ARP34596_P050 Q28BY3_XENTR PR domain containing 8 (Silurana tropicalis) 589 100.00% Xenopus tropicalis (Western clawed frog) prdm8b ARP34596_P050 A4IIY5_XENTR LOC733976 protein (Silurana tropicalis) 353 100.00% Xenopus tropicalis (Western clawed frog) ARP41216_P050 Q6DEP9_XENTR MGC89958 protein (Silurana tropicalis) 155 78.00% ARP41216_P050 Q66KX3_XENLA MGC85348 protein Xenopus laevis (African clawed frog) 155 78.00% Xenopus tropicalis (Western clawed frog) phlda1 ARP54810_P050 Q5EAM8_XENTR MGC108495 protein (Silurana tropicalis) 146 100.00% phlda1 ARP54810_P050 A1L2R3_XENLA LOC100036927 protein Xenopus laevis (African clawed frog) 148 100.00% ARP44362_P050 Q6PCH9_XENLA Npr protein Xenopus laevis (African clawed frog) 680 92.00% ARP44362_P050 A4PID6_XENLA NADPH‐P450 reductase Xenopus laevis (African clawed frog) 680 92.00% Xenopus tropicalis (Western clawed frog) anxa10 ARP36688_P050 A4QNM7_XENTR LOC100125180 protein (Silurana tropicalis) 324 92.00%

ORF Zinc transporter ZIP11 (Solute carrier family Names:v1g167638OrganismNematostel 39 member 11) (Zrt‐ and Irt‐like protein 11) Xenopus tropicalis (Western clawed frog) la vectensis (Starlet sea anemone) ARP44097_P050 S39AB_XENTR (ZIP‐11) (Silurana tropicalis) 336 85.00% ARP38528_P050 Q9W696_XENLA Ets transcription factor (XER81 protein) Xenopus laevis (African clawed frog) 477 85.00% Xenopus tropicalis (Western clawed frog) etv1 ARP38528_P050 Q6P4Z1_XENTR Ets variant 1 (Silurana tropicalis) 495 85.00% etv1 ARP38528_P050 Q6GQB8_XENLA LOC398358 protein Xenopus laevis (African clawed frog) 477 85.00% Ets‐related transcription factor XER81 etv1 ARP38528_P050 O93322_XENLA (Fragment) Xenopus laevis (African clawed frog) 477 85.00% Xenopus tropicalis (Western clawed frog) ARP40966_P050 Q0P4U3_XENTR Polypyrimidine tract binding protein 2 (Silurana tropicalis) 531 85.00% ARP39362_P050 Q2NLA4_XENLA MGC131274 protein Xenopus laevis (African clawed frog) 259 78.00% Xenopus tropicalis (Western clawed frog) ARP39362_P050 B1H3E7_XENTR LOC100145610 protein (Silurana tropicalis) 259 78.00% Zinc finger protein Xfin (Xenopus fingers ZNF316 ARP39476_P050 XFIN_XENLA protein) (Xfin) Xenopus laevis (African clawed frog) 1350 78.00% Xenopus tropicalis (Western clawed frog) NLGN2 ARP49557_P050 D2X2K5_XENTR Neuroligin 2 (Fragment) (Silurana tropicalis) 651 100.00% Xenopus tropicalis (Western clawed frog) NLGN2 ARP49557_P050 D2X2K4_XENTR Neuroligin 1 (Silurana tropicalis) 837 100.00% NLGN2 ARP49557_P050 Q6AX56_XENLA MGC84475 protein (Neuroligin 3) Xenopus laevis (African clawed frog) 803 92.00% Xenopus tropicalis (Western clawed frog) NLGN2 ARP49557_P050 D2X2K7_XENTR Neuroligin 4 (Silurana tropicalis) 813 92.00% Xenopus tropicalis (Western clawed frog) NLGN2 ARP49557_P050 D2X2K6_XENTR Neuroligin 3 (Silurana tropicalis) 803 92.00% L‐lactate dehydrogenase M chain (EC 1.1.1.27) (Lactate dehydrogenase A2) (EC 1.1.1.27) LDHA ARP54777_P050 Q9W5Z7_XENLA (Ldha‐prov protein) Xenopus laevis (African clawed frog) 332 78.00% ORF Names:GSPATT00005146001 EMBL CAK60397.1OrganismParamecium tetraurelia ARP36567_T100 Q6AZN1_XENLA LOC445873 protein (Fragment) Xenopus laevis (African clawed frog) 447 85.00% ORF Names:GSPATT00005146001 EMBL CAK60397.1OrganismParamecium Xenopus tropicalis (Western clawed frog) tetraurelia ARP36567_T100 Q5EB33_XENTR Nucleobindin 2 (Silurana tropicalis) 444 85.00% ORF Names:GSPATT00005146001 EMBL CAK60397.1OrganismParamecium tetraurelia ARP36567_T100 Q569U2_XENLA LOC445873 protein Xenopus laevis (African clawed frog) 450 85.00% ORF Names:GSPATT00005146001 EMBL CAK60397.1OrganismParamecium tetraurelia ARP36567_T100 Q6NTN7_XENLA MGC83153 protein Xenopus laevis (African clawed frog) 457 78.00% ORF Names:GSPATT00013457001 EMBL CAK78010.1OrganismParamecium tetraurelia ARP56292_P050 Q7ZXK2_XENLA LOC398527 protein (Fragment) Xenopus laevis (African clawed frog) 852 100.00% ORF Names:GSPATT00013457001 EMBL CAK78010.1OrganismParamecium tetraurelia ARP56292_P050 Q6DD54_XENLA LOC398527 protein Xenopus laevis (African clawed frog) 1028 100.00% ORF Names:GSPATT00013457001 EMBL CAK78010.1OrganismParamecium Myosin‐Ic‐A (Myosin I beta‐A) (MMI‐beta‐A) tetraurelia ARP56292_P050 MY1CA_XENLA (MMIb‐A) Xenopus laevis (African clawed frog) 1028 100.00% ORF Names:GSPATT00013457001 EMBL CAK78010.1OrganismParamecium tetraurelia ARP56292_P050 Q6NRG8_XENLA MGC83822 protein Xenopus laevis (African clawed frog) 632 92.00% ORF Names:GSPATT00013457001 EMBL CAK78010.1OrganismParamecium tetraurelia ARP56292_P050 Q6IP20_XENLA LOC432231 protein (Fragment) Xenopus laevis (African clawed frog) 808 92.00% ORF Names:GSPATT00013457001 EMBL CAK78010.1OrganismParamecium Xenopus tropicalis (Western clawed frog) tetraurelia ARP56292_P050 Q66JE1_XENTR MGC79641 protein (Silurana tropicalis) 1073 92.00% ORF Names:GSPATT00013457001 EMBL CAK78010.1OrganismParamecium tetraurelia ARP56292_P050 Q5EC17_XENLA Ventricular myosin heavy chain Xenopus laevis (African clawed frog) 1937 92.00% ORF Names:GSPATT00013457001 EMBL CAK78010.1OrganismParamecium tetraurelia ARP56292_P050 Q498L7_XENLA Putative uncharacterized protein Xenopus laevis (African clawed frog) 465 92.00% ORF Names:GSPATT00013457001 EMBL CAK78010.1OrganismParamecium tetraurelia ARP56292_P050 B2Z9Y7_XENLA Laryngeal‐specific muscle myosin heavy chain Xenopus laevis (African clawed frog) 1942 92.00% ARP38234_P050 Q9DG48_XENLA Transcription factor Sox4 Xenopus laevis (African clawed frog) 379 100.00% ARP38234_P050 Q6PCK0_XENLA MGC68880 protein Xenopus laevis (African clawed frog) 387 100.00%

ARP38234_P050 Q6GNL3_XENLA Sox4‐1 protein (Transcription factor Sox4‐2) Xenopus laevis (African clawed frog) 377 100.00% ARP38234_P050 Q33DY2_XENLA Transcription factor Sox4‐1 Xenopus laevis (African clawed frog) 377 100.00% ARP38234_P050 Q33DY1_XENLA Transcription factor Sox4‐2 Xenopus laevis (African clawed frog) 377 100.00% Xenopus tropicalis (Western clawed frog) ARP38234_P050 Q28CP0_XENTR SRY (Sex determining region Y)‐box 4 (Silurana tropicalis) 387 100.00% ARP38234_P050 B7ZRH7_XENLA Transcription factor Sox4‐2 Xenopus laevis (African clawed frog) 377 100.00% ARP38234_P050 Q91730_XENLA DNA‐binding protein Xenopus laevis (African clawed frog) 160 84.00% Transcription factor Sox‐11‐B (Transcription ARP38234_P050 SX11B_XENLA factor Sox‐13) (xSox‐13) (XLS13B) Xenopus laevis (African clawed frog) 374 84.00% Transcription factor Sox‐11‐A (xSox‐11) ARP38234_P050 SX11A_XENLA (XLS13A) Xenopus laevis (African clawed frog) 382 84.00% Transcription factor Sox‐12 (Sox‐K1 protein) (XSox‐K1) (Transcription factor Sox‐33) (xSox‐ ARP38234_P050 SOX12_XENLA 33) (xSox33) Xenopus laevis (African clawed frog) 244 84.00% Xenopus tropicalis (Western clawed frog) ARP38234_P050 SOX11_XENTR Transcription factor Sox‐11 (Silurana tropicalis) 383 84.00% HOXD10 P100936_P050 Q90YE3_XENLA Homeobox protein, Hoxd10 (Fragment) Xenopus laevis (African clawed frog) 311 76.00% HOXD10 P100936_P050 Q6P6Z2_XENLA Hoxd10 protein Xenopus laevis (African clawed frog) 337 76.00%

La‐related protein 7 (La ribonucleoprotein Xenopus tropicalis (Western clawed frog) Larp7 ARP40847_P050 LARP7_XENTR domain family member 7) (Silurana tropicalis) 593 84.00% Nudt13 ARP48782_P050 Q6DD74_XENLA Nudt13‐prov protein Xenopus laevis (African clawed frog) 340 81.00% Xenopus tropicalis (Western clawed frog) LOC515358 ARP40751_P050 MCTS1_XENTR Malignant T cell‐amplified sequence 1 (MCT‐1) (Silurana tropicalis) 181 92.00% Malignant T cell‐amplified sequence 1‐B (MCT‐ LOC515358 ARP40751_P050 MCS1B_XENLA 1B) Xenopus laevis (African clawed frog) 181 92.00% Malignant T cell‐amplified sequence 1‐A (MCT‐ LOC515358 ARP40751_P050 MCS1A_XENLA 1A) Xenopus laevis (African clawed frog) 181 92.00% Menage a trois 1 (Menage a trois 1 (CAK Xenopus tropicalis (Western clawed frog) Mnat1 P100992_P050 Q28H72_XENTR assembly factor)) (Silurana tropicalis) 309 100.00%

CDK‐activating kinase assembly factor MAT1 (CDK7/cyclin‐H assembly factor) (Menage a Mnat1 P100992_P050 MAT1_XENLA trois) (RING finger protein MAT1) Xenopus laevis (African clawed frog) 309 100.00% Xenopus tropicalis (Western clawed frog) mif4gda ARP40950_T100 MI4GD_XENTR MIF4G domain‐containing protein (Silurana tropicalis) 223 90.00% mif4gda ARP40950_T100 M4GDB_XENLA MIF4G domain‐containing protein B Xenopus laevis (African clawed frog) 223 90.00%

ORF Names:DKEY‐189P24.3‐001 EMBL CAM15183.1OrganismDanio rerio Xenopus tropicalis (Western clawed frog) (Zebrafish) (Brachydanio rerio) ARP43387_P050 UBE3B_XENTR Ubiquitin‐protein ligase E3B (EC 6.3.2.‐) (Silurana tropicalis) 1072 78.00% Galactocerebrosidase (GALCERase) (EC Xenopus tropicalis (Western clawed frog) ARP44847_P050 GALC_XENTR 3.2.1.46) (Galactosylceramidase) (Silurana tropicalis) 678 92.00% Galactocerebrosidase (GALCERase) (EC ARP44847_P050 GALC_XENLA 3.2.1.46) (Galactosylceramidase) Xenopus laevis (African clawed frog) 677 92.00% Nuclear receptor subfamily 2 group E member 1 (Nuclear receptor TLX) (Protein tailless NR2E1 ARP32084_P050 NR2E1_XENLA homolog) (Tll) (xTLL) Xenopus laevis (African clawed frog) 386 100.00% NR2E1 ARP32084_P050 Q91840_XENLA Xenopus laevis (African clawed frog) 412 90.00% NR2E1 ARP32084_P050 Q91613_XENLA XRXR beta Xenopus laevis (African clawed frog) 452 90.00% NR2E1 ARP32084_P050 Q6INZ0_XENLA Rxrb protein Xenopus laevis (African clawed frog) 449 90.00% NR2E1 ARP32084_P050 Q6GPF8_XENLA Rxrb‐A‐prov protein (Fragment) Xenopus laevis (African clawed frog) 451 90.00% NR2E1 ARP32084_P050 Q5HZR5_XENLA LOC496325 protein Xenopus laevis (African clawed frog) 470 90.00% NR2E1 ARP32084_P050 Q4KLS2_XENLA MGC115510 protein Xenopus laevis (African clawed frog) 471 90.00% NR2E1 ARP32084_P050 Q4FZW9_XENLA Rxrb‐A‐prov protein (Fragment) Xenopus laevis (African clawed frog) 458 90.00% NR2E1 ARP32084_P050 Q2VPP3_XENLA Rxrb‐a protein (Fragment) Xenopus laevis (African clawed frog) 458 90.00% Retinoic acid receptor RXR‐beta (Retinoid X Xenopus tropicalis (Western clawed frog) NR2E1 ARP32084_P050 Q28CI3_XENTR receptor beta) (Silurana tropicalis) 449 90.00% Xenopus tropicalis (Western clawed frog) NR2E1 ARP32084_P050 Q0IIU2_XENTR LOC779621 protein (Fragment) (Silurana tropicalis) 452 90.00% NR2E1 ARP32084_P050 B7FEW3_XENLA Rxrb‐a protein (Fragment) Xenopus laevis (African clawed frog) 445 90.00% Xenopus tropicalis (Western clawed frog) NR2E1 ARP32084_P050 B3DLT9_XENTR Rxrb protein (Silurana tropicalis) 412 90.00% Retinoic acid receptor RXR‐gamma (Nuclear receptor subfamily 2 group B member 3) NR2E1 ARP32084_P050 RXRG_XENLA (Retinoid X receptor gamma) Xenopus laevis (African clawed frog) 470 90.00% Retinoic acid receptor RXR‐alpha (Nuclear receptor subfamily 2 group B member 1) NR2E1 ARP32084_P050 RXRA_XENLA (Retinoid X receptor alpha) Xenopus laevis (African clawed frog) 488 90.00% NR2E1 ARP32084_P050 Q9W745_XENLA COUP transcription factor 1 Xenopus laevis (African clawed frog) 411 90.00% NR2E1 ARP32084_P050 Q91720_XENLA Coup transcription factor Xenopus laevis (African clawed frog) 397 90.00% NR2E1 ARP32084_P050 Q7ZXI7_XENLA Nr2f2 protein Xenopus laevis (African clawed frog) 405 90.00% NR2E1 ARP32084_P050 Q7T0T7_XENLA Nr2f6 protein Xenopus laevis (African clawed frog) 389 90.00% Nuclear receptor subfamily 2, group F, Xenopus tropicalis (Western clawed frog) NR2E1 ARP32084_P050 Q6GL59_XENTR member 6 (Silurana tropicalis) 389 90.00% NR2E1 ARP32084_P050 Q6DCH6_XENLA Nr2f2 protein Xenopus laevis (African clawed frog) 404 90.00% NR2E1 ARP32084_P050 O42178_XENLA ErbA‐related protein 2 (Fragment) Xenopus laevis (African clawed frog) 63 90.00% Xenopus tropicalis (Western clawed frog) NR2E1 ARP32084_P050 A9ULC1_XENTR Nr2f2 protein (Silurana tropicalis) 408 90.00% Xenopus tropicalis (Western clawed frog) NR2E1 ARP32084_P050 A4QNF4_XENTR Nr2f1 protein (Silurana tropicalis) 410 90.00% PPAR ARP34113_T100 Q6PAY0_XENLA Ppara protein Xenopus laevis (African clawed frog) 474 84.00% PPAR ARP34113_T100 Q6AXA9_XENLA Ppara protein Xenopus laevis (African clawed frog) 474 84.00% Peroxisome proliferator‐activated receptor alpha (PPAR‐alpha) (Nuclear receptor PPAR ARP34113_T100 PPARA_XENLA subfamily 1 group C member 1) Xenopus laevis (African clawed frog) 474 84.00% ARP56132_P050 Q6PHL5_XENLA Rpl27‐prov protein Xenopus laevis (African clawed frog) 136 100.00% Putative uncharacterized protein LOC548934 Xenopus tropicalis (Western clawed frog) ARP56132_P050 Q28FP8_XENTR (Ribosomal protein L27) (Silurana tropicalis) 136 100.00% LOC100049114 ARP36514_P050 A3KNE3_XENLA LOC100049114 protein (Fragment) Xenopus laevis (African clawed frog) 154 92.00% Xenopus tropicalis (Western clawed frog) Zmynd11 ARP34705_T100 B4F738_XENTR Zmynd11 protein (Silurana tropicalis) 622 78.00% Xenopus tropicalis (Western clawed frog) Zmynd11 ARP34705_T100 A4IIZ1_XENTR Zmynd11 protein (Silurana tropicalis) 604 78.00% PCDH1 ARP45331_P050 Q90ZF2_XENLA Axial protocadherin Xenopus laevis (African clawed frog) 1016 92.00% PCDH1 ARP45331_P050 Q6AX49_XENLA Putative uncharacterized protein Xenopus laevis (African clawed frog) 1050 92.00% Xenopus tropicalis (Western clawed frog) PCDH1 ARP45331_P050 A4II80_XENTR Pcdh1 protein (Silurana tropicalis) 1047 92.00% fbxo28 ARP55191_P050 Q66J20_XENLA Putative uncharacterized protein Xenopus laevis (African clawed frog) 345 100.00% Xenopus tropicalis (Western clawed frog) fbxo28 ARP55191_P050 A4QNB1_XENTR LOC100125127 protein (Silurana tropicalis) 345 100.00% RpL18 ARP56127_P050 Q7SZA8_XENLA Rpl18‐b protein Xenopus laevis (African clawed frog) 188 100.00% RpL18 ARP56127_P050 Q7SZA4_XENLA MGC64315 protein Xenopus laevis (African clawed frog) 188 100.00% Xenopus tropicalis (Western clawed frog) RpL18 ARP56127_P050 Q63ZF9_XENTR Ribosomal protein L18 (Silurana tropicalis) 188 100.00% RpL18 ARP56127_P050 Q52MA0_XENLA MGC98504 protein Xenopus laevis (African clawed frog) 188 100.00% RpL18 ARP56127_P050 RL18B_XENLA 60S ribosomal protein L18‐B (L14B) Xenopus laevis (African clawed frog) 188 100.00% RpL18 ARP56127_P050 RL18A_XENLA 60S ribosomal protein L18‐A (L14A) Xenopus laevis (African clawed frog) 188 100.00% Xenopus tropicalis (Western clawed frog) ARP38481_P050 A4II00_XENTR Onecut1 protein (Silurana tropicalis) 493 78.00% Ordered Locus Names:Mpe_B0579Encoded onPlasmid RPME01 EMBL ABM97345.1OrganismMethylibium Xenopus tropicalis (Western clawed frog) petroleiphilum (strain PM1) ARP42474_P050 Q5FVV8_XENTR Pipox‐prov protein (Fragment) (Silurana tropicalis) 390 100.00% Ordered Locus Names:Mpe_B0579Encoded onPlasmid RPME01 EMBL ABM97345.1OrganismMethylibium petroleiphilum (strain PM1) ARP42474_P050 Q3KPZ3_XENLA MGC131181 protein Xenopus laevis (African clawed frog) 393 100.00% Ordered Locus Names:Mpe_B0579Encoded onPlasmid RPME01 EMBL ABM97345.1OrganismMethylibium Xenopus tropicalis (Western clawed frog) petroleiphilum (strain PM1) ARP42474_P050 B0BMN6_XENTR Pipox protein (Silurana tropicalis) 393 100.00% CH73‐81E6.1 ARP54915_P050 Q66IY7_XENLA MGC84050 protein Xenopus laevis (African clawed frog) 436 100.00% Xenopus tropicalis (Western clawed frog) CH73‐81E6.1 ARP54915_P050 B2GUK1_XENTR LOC100158600 protein (Fragment) (Silurana tropicalis) 434 100.00% Xenopus tropicalis (Western clawed frog) CH73‐81E6.1 ARP54915_P050 B2GU12_XENTR LOC100158480 protein (Silurana tropicalis) 437 78.00% ARP44875_P050 Q52L15_XENLA MGC114730 protein Xenopus laevis (African clawed frog) 806 78.00% ORF Names:GSPATT00033463001 EMBL CAK63610.1OrganismParamecium Xenopus tropicalis (Western clawed frog) tetraurelia ARP48152_P050 Q5BKI5_XENTR Pyruvate dehydrogenase (Lipoamide) beta (Silurana tropicalis) 360 85.00% ORF Names:GSPATT00033463001 EMBL CAK63610.1OrganismParamecium tetraurelia ARP48152_P050 Q6GR17_XENLA PdhE1beta‐1 protein Xenopus laevis (African clawed frog) 360 78.00% ORF Names:GSPATT00033463001 EMBL CAK63610.1OrganismParamecium tetraurelia ARP48152_P050 Q5XGY5_XENLA PdhE1beta‐2 protein Xenopus laevis (African clawed frog) 360 78.00% ORF Names:GSPATT00033463001 EMBL CAK63610.1OrganismParamecium Pyruvate dehydrogenase E1‐beta subunit tetraurelia ARP48152_P050 P79932_XENLA (Fragment) Xenopus laevis (African clawed frog) 339 78.00% ORF Names:GSPATT00033463001 EMBL CAK63610.1OrganismParamecium Pyruvate dehydrogenase E1‐beta subunit tetraurelia ARP48152_P050 P79931_XENLA (Fragment) Xenopus laevis (African clawed frog) 359 78.00% Xenopus tropicalis (Western clawed frog) Hoxb8 ARP39583_P050 Q6DIE5_XENTR Homeo box C8 (Homeobox C8) (Silurana tropicalis) 242 78.00% Hoxb8 ARP39583_P050 O42139_XENLA Homeobox protein pXhoxc8 Xenopus laevis (African clawed frog) 256 78.00% Xenopus tropicalis (Western clawed frog) LOC100127860 ARP45307_T100 A9JTV3_XENTR LOC100127860 protein (Silurana tropicalis) 147 78.00% Hydroxyacid‐oxoacid transhydrogenase, ORF Names:ACLA_090080 EMBL mitochondrial (HOT) (EC 1.1.99.24) (Alcohol EAW11315.1OrganismAspergillus dehydrogenase iron‐containing protein 1) Xenopus tropicalis (Western clawed frog) clavatus ARP52720_P050 HOT_XENTR (ADHFe1) (Silurana tropicalis) 463 100.00% Hydroxyacid‐oxoacid transhydrogenase, ORF Names:ACLA_090080 EMBL mitochondrial (HOT) (EC 1.1.99.24) (Alcohol EAW11315.1OrganismAspergillus dehydrogenase iron‐containing protein 1) clavatus ARP52720_P050 HOT_XENLA (ADHFe1) Xenopus laevis (African clawed frog) 463 91.00% ARP51808_P050 Q7ZYP8_XENLA LOC495278 protein (Fragment) Xenopus laevis (African clawed frog) 561 100.00% ARP51808_P050 Q7ZXA9_XENLA Cct7‐prov protein (Fragment) Xenopus laevis (African clawed frog) 554 100.00% Xenopus tropicalis (Western clawed frog) ARP51808_P050 Q6NVB2_XENTR Cct7 protein (Fragment) (Silurana tropicalis) 571 100.00% ARP51808_P050 Q6DCS0_XENLA Cct7‐prov protein Xenopus laevis (African clawed frog) 542 100.00% ARP51808_P050 Q5XGK8_XENLA LOC495278 protein Xenopus laevis (African clawed frog) 480 100.00% Xenopus tropicalis (Western clawed frog) ARP51808_P050 Q5D024_XENTR Chaperonin containing TCP1, subunit 7 (Eta) (Silurana tropicalis) 542 100.00%

ARP51808_P050 A1L3L2_XENLA Putative uncharacterized protein (Fragment) Xenopus laevis (African clawed frog) 148 100.00% Kremen protein 1 (Dickkopf receptor) (Kringle‐ containing protein marking the eye and the si:dkeyp‐7c9.1 ARP44879_P050 KREM1_XENLA nose) Xenopus laevis (African clawed frog) 452 100.00% Xenopus tropicalis (Western clawed frog) TBX15 ARP40123_P050 B7ZSN5_XENTR T‐box 20 (Silurana tropicalis) 440 100.00% TBX15 ARP40123_P050 B7ZQT9_XENLA T‐box 20 Xenopus laevis (African clawed frog) 441 100.00% T‐box transcription factor TBX20 (T‐box Xenopus tropicalis (Western clawed frog) TBX15 ARP40123_P050 TBX20_XENTR protein 20) (Silurana tropicalis) 440 100.00% T‐box transcription factor TBX20 (T‐box TBX15 ARP40123_P050 TBX20_XENLA protein 20) Xenopus laevis (African clawed frog) 441 100.00%

TPM2 ARP41141_P050 Q9DGF9_XENLA Muscle alphafast‐tropomyosin (Fragment) Xenopus laevis (African clawed frog) 63 100.00%

TPM2 ARP41141_P050 Q9DGF8_XENLA Nonmuscle alphafast‐tropomyosin (Fragment) Xenopus laevis (African clawed frog) 63 100.00% TPM2 ARP41141_P050 Q91866_XENLA Tm7 protein (Tropomyosin) Xenopus laevis (African clawed frog) 248 100.00% TPM2 ARP41141_P050 Q91864_XENLA Tropomyosin Xenopus laevis (African clawed frog) 248 100.00% TPM2 ARP41141_P050 Q6IP24_XENLA Putative uncharacterized protein Xenopus laevis (African clawed frog) 284 100.00% Xenopus tropicalis (Western clawed frog) TPM2 ARP41141_P050 Q6DFM4_XENTR Tropomyosin 1 (Alpha) (Silurana tropicalis) 248 100.00% TPM2 ARP41141_P050 O73681_XENLA Alpha‐tropomyosin Xenopus laevis (African clawed frog) 248 100.00% Xenopus tropicalis (Western clawed frog) TPM2 ARP41141_P050 B1H2X3_XENTR Tpm1 protein (Silurana tropicalis) 284 100.00% Xenopus tropicalis (Western clawed frog) TPM2 ARP41141_P050 B0BMH6_XENTR Tpm1 protein (Silurana tropicalis) 284 100.00% Xenopus tropicalis (Western clawed frog) TPM2 ARP41141_P050 A9JSN1_XENTR LOC100127765 protein (Fragment) (Silurana tropicalis) 177 100.00% TPM2 ARP41141_P050 TPM1_XENLA Isoform 2 (Isoform non‐muscle) Xenopus laevis (African clawed frog) 248 100.00% Tropomyosin alpha‐1 chain (Alpha‐ TPM2 ARP41141_P050 TPM1_XENLA tropomyosin) (Tropomyosin‐1) Xenopus laevis (African clawed frog) 284 100.00% TPM2 ARP41141_P050 Q91865_XENLA Non‐muscle tropomyosin Xenopus laevis (African clawed frog) 248 92.00% TPM2 ARP41141_P050 Q91726_XENLA Cardiac tropomyosin Xenopus laevis (African clawed frog) 284 92.00% TPM2 ARP41141_P050 Q7SYY4_XENLA MGC64401 protein Xenopus laevis (African clawed frog) 284 92.00% TPM2 ARP41141_P050 Q6QJD1_XENLA Alpha fast tropomyosin (Fragment) Xenopus laevis (African clawed frog) 71 100.00% TPM2 ARP41141_P050 Q6QJD0_XENLA Alpha fast tropomyosin (Fragment) Xenopus laevis (African clawed frog) 71 100.00% TPM2 ARP41141_P050 Q6PF72_XENLA Tm‐4 protein Xenopus laevis (African clawed frog) 248 92.00% Xenopus tropicalis (Western clawed frog) TPM2 ARP41141_P050 Q28GF0_XENTR Tpm3 protein (Tropomyosin 4) (Silurana tropicalis) 248 92.00% TPM2 ARP41141_P050 Q7ZY45_XENLA TPM3 protein (Fragment) Xenopus laevis (African clawed frog) 255 92.00% TPM2 ARP41141_P050 Q6PA57_XENLA MGC68479 protein Xenopus laevis (African clawed frog) 245 92.00% Xenopus tropicalis (Western clawed frog) TPM2 ARP41141_P050 Q6P330_XENTR Putative uncharacterized protein MGC76092 (Silurana tropicalis) 245 92.00% TPM2 ARP41141_P050 Q5U4J6_XENLA TPM3 protein Xenopus laevis (African clawed frog) 158 92.00% Xenopus tropicalis (Western clawed frog) TPM2 ARP41141_P050 Q28EJ3_XENTR Tropomyosin 3 (Silurana tropicalis) 250 92.00% Fast skeletal muscle beta‐tropomyosin TPM2 ARP41141_P050 Q91706_XENLA (Putative uncharacterized protein) Xenopus laevis (African clawed frog) 284 92.00% si:dkey‐20i20.5 ARP47687_P050 Q5XGZ3_XENLA LOC495109 protein (Fragment) Xenopus laevis (African clawed frog) 637 90.00% si:dkey‐20i20.5 ARP47687_P050 Q32N45_XENLA LOC495109 protein Xenopus laevis (African clawed frog) 658 90.00% Xenopus tropicalis (Western clawed frog) si:dkey‐20i20.5 ARP47687_P050 B0S4Q2_XENTR Putative uncharacterized protein (Silurana tropicalis) 215 100.00% ARP43556_P050 Q5XGK9_XENLA LOC495197 protein Xenopus laevis (African clawed frog) 521 92.00% ARP43556_P050 Q642N7_XENLA LOC446968 protein (Fragment) Xenopus laevis (African clawed frog) 545 84.00% Xenopus tropicalis (Western clawed frog) Kctd15 ARP35355_P050 KCD15_XENTR BTB/POZ domain‐containing protein kctd15 (Silurana tropicalis) 255 100.00%

Kctd15 ARP35355_P050 KCD15_XENLA BTB/POZ domain‐containing protein kctd15 Xenopus laevis (African clawed frog) 255 100.00% Xenopus tropicalis (Western clawed frog) fam176a ARP50039_P050 A4IHF0_XENTR LOC100124835 protein (Silurana tropicalis) 138 78.00% LOC100036860 ARP48756_P050 Q6IU13_XENLA NIMA‐family kinase Nek7 (Nek7 protein) Xenopus laevis (African clawed frog) 302 92.00% NIMA‐family kinase Nek6 (Nek6 protein) LOC100036860 ARP48756_P050 Q7ZSX4_XENLA (Nek6‐prov protein) Xenopus laevis (African clawed frog) 310 92.00% NIMA (Never in mitosis gene a)‐related expressed kinase 6 (NIMA (Never in mitosis Xenopus tropicalis (Western clawed frog) LOC100036860 ARP48756_P050 Q6DIX9_XENTR gene a)‐related kinase 6) (Silurana tropicalis) 310 92.00% LOC100036860 ARP48756_P050 A1L2I8_XENLA LOC100036860 protein Xenopus laevis (African clawed frog) 310 85.00% Xenopus tropicalis (Western clawed frog) LOC100036860 ARP48756_P050 Q0IHX5_XENTR Putative uncharacterized protein MGC145434 (Silurana tropicalis) 302 78.00% NAPA AVARP13049_T100 Q6GNP4_XENLA MGC80970 protein Xenopus laevis (African clawed frog) 295 78.00% NAPA AVARP13049_T100 Q6AZJ3_XENLA Napb protein Xenopus laevis (African clawed frog) 295 78.00%

N‐ethylmaleimide‐sensitive factor attachment protein, alpha (N‐ethylmaleimide‐sensitive Xenopus tropicalis (Western clawed frog) NAPA AVARP13049_T100 Q5M8J7_XENTR factor attachment protein, beta) (Silurana tropicalis) 295 78.00% Xenopus tropicalis (Western clawed frog) RAD54L ARP36355_P050 Q6NVL9_XENTR RAD54‐like (S. cerevisiae) (Silurana tropicalis) 742 85.00% ORF Names:VITISV_000210 EMBL CAN68909.1, VIT_00032102001 EMBL CBI24893.3OrganismVitis vinifera (Grape) ARP56134_P050 Q7SZC0_XENLA Rpl30‐prov protein Xenopus laevis (African clawed frog) 116 100.00% ORF Names:VITISV_000210 EMBL CAN68909.1, VIT_00032102001 EMBL CBI24893.3OrganismVitis vinifera (Grape) ARP56134_P050 Q6GNF2_XENLA MGC82844 protein Xenopus laevis (African clawed frog) 116 100.00% ORF Names:VITISV_000210 EMBL CAN68909.1, VIT_00032102001 EMBL CBI24893.3OrganismVitis vinifera Xenopus tropicalis (Western clawed frog) (Grape) ARP56134_P050 Q6DEP8_XENTR MGC89963 protein (Silurana tropicalis) 116 100.00% ORF Names:VITISV_000210 EMBL CAN68909.1, VIT_00032102001 EMBL CBI24893.3OrganismVitis vinifera (Grape) ARP56134_P050 B2L4E3_XENBO Ribosomal protein L30 (Fragment) Xenopus borealis (Kenyan clawed frog) 53 100.00% rrp3 ARP36440_T100 Q6NTW0_XENLA MGC81500 protein Xenopus laevis (African clawed frog) 317 92.00% rrp3 ARP36440_T100 Q6INR0_XENLA MGC81303 protein Xenopus laevis (African clawed frog) 448 92.00% Xenopus tropicalis (Western clawed frog) rrp3 ARP36440_T100 Q6P636_XENTR Ddx47‐prov protein (Fragment) (Silurana tropicalis) 401 100.00% slc26a4 ARP44176_T100 Q6DCJ6_XENLA Slc26a4‐prov protein Xenopus laevis (African clawed frog) 773 76.00% slc26a4 ARP44176_T100 Q5QKY0_XENLA Anion exchanger SLC26A4 Xenopus laevis (African clawed frog) 778 76.00% slc26a4 ARP44176_T100 B7ZQ94_XENLA Anion exchanger SLC26A4 (Pendrin protein) Xenopus laevis (African clawed frog) 778 76.00% Slc26a4 protein (Solute carrier family 26, Xenopus tropicalis (Western clawed frog) slc26a4 ARP44176_T100 A9UM38_XENTR member 4) (Silurana tropicalis) 778 76.00% Xenopus tropicalis (Western clawed frog) slc26a4 ARP44176_T100 A0JM84_XENTR Slc26a4 protein (Fragment) (Silurana tropicalis) 767 76.00% galT ARP48469_P050 Q5PPT7_XENLA LOC496084 protein (Fragment) Xenopus laevis (African clawed frog) 376 92.00% Xenopus tropicalis (Western clawed frog) galT ARP48469_P050 Q504Q1_XENTR Galactose‐1‐phosphate uridylyltransferase (Silurana tropicalis) 247 92.00% Transcription factor LBX1 (Ladybird homeobox Xenopus tropicalis (Western clawed frog) Lbx1 ARP32808_P050 LBX1_XENTR protein homolog 1) (Silurana tropicalis) 265 100.00% Transcription factor LBX1 (Ladybird homeobox Lbx1 ARP32808_P050 LBX1_XENLA protein homolog 1) Xenopus laevis (African clawed frog) 267 100.00% ARP32515_P050 C6GGW6_XENLA Suppressor of zeste 12 Xenopus laevis (African clawed frog) 696 85.00% ARP32515_P050 B3DLL6_XENLA LOC100174799 protein Xenopus laevis (African clawed frog) 445 85.00% Polycomb protein suz12 (Suppressor of zeste Xenopus tropicalis (Western clawed frog) ARP32515_P050 SUZ12_XENTR 12 protein homolog) (Silurana tropicalis) 700 85.00% Ionotropic glutamate receptor subunit KA1 GRIK4 ARP37674_P050 B9V8R1_XENLA (Fragment) Xenopus laevis (African clawed frog) 168 85.00% Xenopus tropicalis (Western clawed frog) TMEM115 ARP46814_P050 A9UME0_XENTR LOC100135324 protein (Silurana tropicalis) 361 84.00% ORF Names:GSPATT00004929001 EMBL CAK58556.1OrganismParamecium Xenopus tropicalis (Western clawed frog) tetraurelia ARP41398_T100 Q6P1T2_XENTR Methionine adenosyltransferase II, alpha (Silurana tropicalis) 396 92.00% ORF Names:GSPATT00004929001 EMBL CAK58556.1OrganismParamecium Xenopus tropicalis (Western clawed frog) tetraurelia ARP41398_T100 Q66KL3_XENTR Methionine adenosyltransferase II, alpha (Silurana tropicalis) 396 92.00% ORF Names:GSPATT00004929001 EMBL CAK58556.1OrganismParamecium tetraurelia ARP41398_T100 Q7ZY54_XENLA M(2)21ab protein Xenopus laevis (African clawed frog) 396 92.00% ORF Names:GSPATT00004929001 EMBL CAK58556.1OrganismParamecium tetraurelia ARP41398_T100 Q4KLX5_XENLA M(2)21ab‐prov protein Xenopus laevis (African clawed frog) 363 92.00% ORF Names:GSPATT00004929001 EMBL CAK58556.1OrganismParamecium Xenopus tropicalis (Western clawed frog) tetraurelia ARP41398_T100 A9JTV0_XENTR LOC100127858 protein (Silurana tropicalis) 396 85.00% Xenopus tropicalis (Western clawed frog) ARP32691_P050 A0JP90_XENTR Mafk protein (Silurana tropicalis) 156 100.00% mafk ARP32691_P050 Q5U4S3_XENLA LOC495449 protein Xenopus laevis (African clawed frog) 148 85.00% Proteasome (Prosome, macropain) 26S Xenopus tropicalis (Western clawed frog) Psmc3 ARP32929_T100 Q6DIE6_XENTR subunit, ATPase, 3 (Silurana tropicalis) 423 100.00% Psmc3 ARP32929_T100 Q7ZWL9_XENLA Psmc3‐b protein Xenopus laevis (African clawed frog) 423 92.00%

26S protease regulatory subunit 6A‐B (26S proteasome AAA‐ATPase subunit RPT5‐B) (Proteasome 26S subunit ATPase 3‐B) (Tat‐ Psmc3 ARP32929_T100 PR6AB_XENLA binding protein 10) (TBP‐10) Xenopus laevis (African clawed frog) 404 92.00% Psmc3 ARP32929_T100 Q7SZ30_XENLA Psmc3‐prov protein Xenopus laevis (African clawed frog) 423 92.00%

26S protease regulatory subunit 6A‐A (26S proteasome AAA‐ATPase subunit RPT5‐A) (Proteasome 26S subunit ATPase 3‐A) (Tat‐ Psmc3 ARP32929_T100 PR6AA_XENLA binding protein 6) (TBP‐6) Xenopus laevis (African clawed frog) 405 92.00% dntt‐A ARP52032_P050 A2VDB4_XENLA Dntt‐A protein (Fragment) Xenopus laevis (African clawed frog) 500 90.00% DNA nucleotidylexotransferase (EC 2.7.7.31) (Terminal addition enzyme) (Terminal deoxynucleotidyltransferase) (TDT) (Terminal dntt‐A ARP52032_P050 TDT_XENLA transferase) Xenopus laevis (African clawed frog) 507 90.00% Xenopus tropicalis (Western clawed frog) ARP31932_P050 A9UM33_XENTR LOC100135241 protein (Silurana tropicalis) 259 76.00% ARP31932_P050 Q4V7N5_XENLA MGC115522 protein Xenopus laevis (African clawed frog) 233 76.00% Lhx9 P100884_T100 B7U6H6_XENLA LHX9 Xenopus laevis (African clawed frog) 399 85.00% LIM/homeobox protein Lhx9 (LIM homeobox Lhx9 P100884_T100 LHX9_XENLA protein 9) Xenopus laevis (African clawed frog) 331 85.00% Lhx9 P100884_T100 Q98SF7_XENLA Lhx9 protein (Fragment) Xenopus laevis (African clawed frog) 217 78.00% si:dkeyp‐73c8.2 ARP45268_P050 Q52KS3_XENLA MGC115205 protein Xenopus laevis (African clawed frog) 601 92.00% Xenopus tropicalis (Western clawed frog) si:dkeyp‐73c8.2 ARP45268_P050 Q0P4M3_XENTR Lrch4 protein (Fragment) (Silurana tropicalis) 717 92.00% ORF Names:TRIADDRAFT_49668 EMBL EDV29525.1OrganismTrichoplax adhaerens (Trichoplax reptans) ARP58175_P050 Q7ZWL9_XENLA Psmc3‐b protein Xenopus laevis (African clawed frog) 423 100.00%

ORF Names:TRIADDRAFT_49668 EMBL EDV29525.1OrganismTrichoplax adhaerens (Trichoplax reptans) ARP58175_P050 Q7SZ30_XENLA Psmc3‐prov protein Xenopus laevis (African clawed frog) 423 100.00%

ORF Names:TRIADDRAFT_49668 EMBL EDV29525.1OrganismTrichoplax Proteasome (Prosome, macropain) 26S Xenopus tropicalis (Western clawed frog) adhaerens (Trichoplax reptans) ARP58175_P050 Q6DIE6_XENTR subunit, ATPase, 3 (Silurana tropicalis) 423 100.00%

26S protease regulatory subunit 6A‐B (26S ORF Names:TRIADDRAFT_49668 EMBL proteasome AAA‐ATPase subunit RPT5‐B) EDV29525.1OrganismTrichoplax (Proteasome 26S subunit ATPase 3‐B) (Tat‐ adhaerens (Trichoplax reptans) ARP58175_P050 PR6AB_XENLA binding protein 10) (TBP‐10) Xenopus laevis (African clawed frog) 404 100.00%

26S protease regulatory subunit 6A‐A (26S ORF Names:TRIADDRAFT_49668 EMBL proteasome AAA‐ATPase subunit RPT5‐A) EDV29525.1OrganismTrichoplax (Proteasome 26S subunit ATPase 3‐A) (Tat‐ adhaerens (Trichoplax reptans) ARP58175_P050 PR6AA_XENLA binding protein 6) (TBP‐6) Xenopus laevis (African clawed frog) 405 100.00% P100958_P050 Q98SI7_XENLA Transcription factor Otx1 Xenopus laevis (African clawed frog) 339 100.00% P100958_P050 Q0IH93_XENLA Otx1‐A protein Xenopus laevis (African clawed frog) 338 100.00% Xenopus tropicalis (Western clawed frog) P100958_P050 Q6P4Y7_XENTR Orthodenticle homeobox 1 (Silurana tropicalis) 336 92.00% Xenopus tropicalis (Western clawed frog) P100958_P050 B1H3B9_XENTR Cone‐rod homeobox (Silurana tropicalis) 290 85.00% Homeobox protein otx5 (Orthodenticle Xenopus tropicalis (Western clawed frog) P100958_P050 OTX5_XENTR homolog 5) (Silurana tropicalis) 290 85.00% Homeobox protein otx5‐B (Orthodenticle P100958_P050 OTX5B_XENLA homolog 5‐B) (XOtx5b) Xenopus laevis (African clawed frog) 290 85.00% Homeobox protein otx5‐A (Orthodenticle P100958_P050 OTX5A_XENLA homolog 5‐A) (Xotx5) Xenopus laevis (African clawed frog) 290 85.00% Xenopus tropicalis (Western clawed frog) P100958_P050 OTX2_XENTR Homeobox protein OTX2 (Orthodenticle 2) (Silurana tropicalis) 289 80.00% Homeobox protein OTX2‐B (xOTX2‐B) (Orthodenticle 2‐B) (Orthodenticle‐A‐like P100958_P050 OTX2B_XENLA protein B) Xenopus laevis (African clawed frog) 289 80.00% Homeobox protein OTX2‐A (xOTX2‐A) (Orthodenticle 2‐A) (Orthodenticle‐A‐like P100958_P050 OTX2A_XENLA protein A) Xenopus laevis (African clawed frog) 288 80.00% PAX1 ARP34268_P050 Q0PZI2_XENLA Paired box protein 1 Xenopus laevis (African clawed frog) 358 76.00% ORF Names:OsJ_15669 EMBL EAZ31529.1OrganismOryza sativa subsp. japonica (Rice) ARP58689_P050 Q5XHE2_XENLA LOC495025 protein Xenopus laevis (African clawed frog) 230 85.00% ORF Names:OsJ_15669 EMBL EAZ31529.1OrganismOryza sativa Ubiquitin carboxyl‐terminal esterase L3 Xenopus tropicalis (Western clawed frog) subsp. japonica (Rice) ARP58689_P050 Q28GY5_XENTR (Ubiquitin carboxyl‐terminal esterase L4) (Silurana tropicalis) 230 78.00%

ORF Names:v1g244232OrganismNematostel Xenopus tropicalis (Western clawed frog) la vectensis (Starlet sea anemone) ARP35127_T100 Q0D2D8_XENTR Cullin 5 (Silurana tropicalis) 780 100.00%

ORF Names:v1g244232OrganismNematostel la vectensis (Starlet sea anemone) ARP35127_T100 A7VK04_XENLA Cullin5 Xenopus laevis (African clawed frog) 780 100.00%

ORF Names:AGAP001816OrganismAnophel es gambiae (African malaria mosquito) ARP39223_P050 Q5M9B0_XENLA LOC496146 protein Xenopus laevis (African clawed frog) 240 100.00%

ORF Names:AGAP001816OrganismAnophel es gambiae (African malaria mosquito) ARP39223_P050 CN166_XENLA UPF0568 protein C14orf166 homolog Xenopus laevis (African clawed frog) 240 92.00%

ORF Names:AGAP001816OrganismAnophel Putative uncharacterized protein C14orf166 es gambiae (African malaria mosquito) ARP39223_P050 B2L558_XENBO (Fragment) Xenopus borealis (Kenyan clawed frog) 32 100.00% Xenopus tropicalis (Western clawed frog) ARP32716_T100 A0JM27_XENTR Nfib protein (Silurana tropicalis) 558 100.00% nfib ARP32716_T100 Q91797_XENLA ‐B1 Xenopus laevis (African clawed frog) 536 92.00%

ORF Names:MGG_04189 EMBL EDJ99494.1OrganismMagnaporthe oryzae (strain 70‐15 / FGSC 8958) (Rice blast fungus) (Pyricularia oryzae) ARP58771_P050 Q6NTU6_XENLA MGC82225 protein Xenopus laevis (African clawed frog) 142 76.00%

ORF Names:MGG_04189 EMBL EDJ99494.1OrganismMagnaporthe oryzae (strain 70‐15 / FGSC 8958) (Rice blast fungus) (Pyricularia oryzae) ARP58771_P050 Q66L30_XENLA MGC85221 protein Xenopus laevis (African clawed frog) 126 76.00% ORF Names:MGG_04189 EMBL EDJ99494.1OrganismMagnaporthe oryzae (strain 70‐15 / FGSC 8958) (Rice Xenopus tropicalis (Western clawed frog) blast fungus) (Pyricularia oryzae) ARP58771_P050 Q5BIZ3_XENTR Gmfg protein (Silurana tropicalis) 142 76.00%

ORF Names:An04g09260 EMBL CAK39012.1OrganismAspergillus niger Xenopus tropicalis (Western clawed frog) (strain CBS 513.88 / FGSC A1513) AVARP02043_P050 Q6P3Q1_XENTR WD repeat domain 3 (Silurana tropicalis) 941 92.00%

ORF Names:An04g09260 EMBL CAK39012.1OrganismAspergillus niger (strain CBS 513.88 / FGSC A1513) AVARP02043_P050 Q52L18_XENLA LOC443590 protein Xenopus laevis (African clawed frog) 942 92.00% rere ARP32713_P050 Q640I1_XENLA LOC494667 protein Xenopus laevis (African clawed frog) 135 100.00% rere ARP32713_P050 A1L1H0_XENLA LOC100036839 protein Xenopus laevis (African clawed frog) 1529 100.00% ORF Names:GSPATT00030650001 EMBL CAK60012.1OrganismParamecium tetraurelia ARP53820_P050 Q7ZYH7_XENLA Pgk1‐prov protein Xenopus laevis (African clawed frog) 417 85.00% ORF Names:GSPATT00030650001 EMBL CAK60012.1OrganismParamecium tetraurelia ARP53820_P050 Q6DD48_XENLA Pgk2 protein Xenopus laevis (African clawed frog) 417 85.00% 6‐pyruvoyl‐tetrahydropterin synthase/dimerization cofactor of hepatocyte Xenopus tropicalis (Western clawed frog) GF23365 ARP32447_P050 Q640A1_XENTR nuclear factor 1 alpha (TCF1) (Silurana tropicalis) 104 78.00% GF23365 ARP32447_P050 Q5HZL2_XENLA LOC496367 protein Xenopus laevis (African clawed frog) 104 78.00%

Pterin‐4‐alpha‐carbinolamine dehydratase (PHS) (EC 4.2.1.96) (4‐alpha‐hydroxy‐ tetrahydropterin dehydratase) (Dimerization cofactor of hepatocyte nuclear factor 1‐alpha) (DCoH) (Dimerization cofactor of HNF1) (xDCoH) (Phenylalanine hydroxylase‐ stimulating protein) (Pterin carbinolamine GF23365 ARP32447_P050 PHS_XENLA dehydratase) (PCD) Xenopus laevis (African clawed frog) 104 78.00% Taf2 ARP33392_P050 Q6DCR8_XENLA TAF2 protein (Fragment) Xenopus laevis (African clawed frog) 594 92.00% ARP38714_P050 A9UMN5_XENLA LOC100137690 protein Xenopus laevis (African clawed frog) 497 76.00% ARP45714_P050 Q7SYR9_XENLA MGC64545 protein Xenopus laevis (African clawed frog) 294 91.00% rbpjb ARP34710_P050 A3KMT5_XENLA XSu(H)1 protein Xenopus laevis (African clawed frog) 487 78.00% rbpjb ARP34710_P050 SUH_XENLA Isoform 2 (Isoform X‐Su(H)2) Xenopus laevis (African clawed frog) 481 78.00% Suppressor of hairless protein homolog (X‐ rbpjb ARP34710_P050 SUH_XENLA Su(H)) Xenopus laevis (African clawed frog) 501 78.00% DJC17 ARP39663_P050 B7ZPQ0_XENLA Mxd1 protein Xenopus laevis (African clawed frog) 221 100.00% Max dimerization protein 1 (Max dimerizer 1) Xenopus tropicalis (Western clawed frog) DJC17 ARP39663_P050 MAD1_XENTR (Protein MAD) (Silurana tropicalis) 221 100.00% Max dimerization protein 1 (Max dimerizer 1) DJC17 ARP39663_P050 MAD1_XENLA (Protein MAD) Xenopus laevis (African clawed frog) 221 100.00% Basic helix‐loop‐helix transcription factor DJC17 ARP39663_P050 Q9W6H3_XENLA XMad4‐67 Xenopus laevis (African clawed frog) 67 92.00% Basic helix‐loop‐helix transcription factor DJC17 ARP39663_P050 Q9W6H2_XENLA XMad4‐236 Xenopus laevis (African clawed frog) 236 92.00% Basic helix‐loop‐helix transcription factor XMad4 (Basic helix‐loop‐helix transcription DJC17 ARP39663_P050 Q9W6H1_XENLA factor XMad4‐204) Xenopus laevis (African clawed frog) 204 92.00% Xenopus tropicalis (Western clawed frog) DJC17 ARP39663_P050 A4IH47_XENTR LOC100124794 protein (Silurana tropicalis) 204 92.00% Xenopus tropicalis (Western clawed frog) DJC17 ARP39663_P050 B3DLA4_XENTR MAX dimerization protein 3 (Silurana tropicalis) 200 100.00%

Max dimerization protein 3 (Max dimerizer 3) (Max‐associated protein 3) (Max‐interacting Xenopus tropicalis (Western clawed frog) DJC17 ARP39663_P050 MAD3_XENTR transcriptional repressor MAD3) (Silurana tropicalis) 200 100.00%

Max dimerization protein 3 (Max dimerizer 3) (Max‐associated protein 3) (Max‐interacting DJC17 ARP39663_P050 MAD3_XENLA transcriptional repressor MAD3) Xenopus laevis (African clawed frog) 200 100.00% DJC17 ARP39663_P050 Q5HZZ5_XENLA Xmad4 protein Xenopus laevis (African clawed frog) 203 85.00% KLF6 ARP35640_P050 Q7ZXK7_XENLA Copeb‐prov protein Xenopus laevis (African clawed frog) 283 100.00% Xenopus tropicalis (Western clawed frog) KLF6 ARP35640_P050 Q68FA0_XENTR Copeb protein (Silurana tropicalis) 283 100.00% KLF6 ARP35640_P050 Q66KQ9_XENLA LOC446965 protein (Fragment) Xenopus laevis (African clawed frog) 278 100.00% mkrn2 ARP43143_P050 Q3KQ17_XENLA MGC131105 protein Xenopus laevis (African clawed frog) 409 92.00% Probable E3 ubiquitin‐protein ligase makorin‐ Xenopus tropicalis (Western clawed frog) mkrn2 ARP43143_P050 MKRN2_XENTR 2 (EC 6.3.2.‐) (Silurana tropicalis) 418 92.00% Probable E3 ubiquitin‐protein ligase makorin‐ mkrn2 ARP43143_P050 MKRN2_XENLA 2 (EC 6.3.2.‐) Xenopus laevis (African clawed frog) 409 92.00%

ORF Names:v1g243663OrganismNematostel la vectensis (Starlet sea anemone) ARP32378_T100 Q801R1_XENLA Ruvbl2‐prov protein Xenopus laevis (African clawed frog) 462 92.00%

ORF Names:v1g243663OrganismNematostel Xenopus tropicalis (Western clawed frog) la vectensis (Starlet sea anemone) ARP32378_T100 Q28GB7_XENTR RuvB‐like 2 (Silurana tropicalis) 462 92.00% ORF Names:v1g243663OrganismNematostel la vectensis (Starlet sea anemone) ARP32378_T100 Q0IH85_XENLA LOC398205 protein Xenopus laevis (African clawed frog) 462 92.00%

ORF Names:v1g243663OrganismNematostel la vectensis (Starlet sea anemone) ARP32378_T100 RUVB2_XENLA RuvB‐like 2 (EC 3.6.4.12) (Reptin) Xenopus laevis (African clawed frog) 462 92.00% ARP48218_P050 Q58E92_XENLA MGC84939 protein Xenopus laevis (African clawed frog) 117 100.00% Queuine tRNA‐ribosyltransferase (EC 2.4.2.29) (Guanine insertion enzyme) (tRNA‐guanine Xenopus tropicalis (Western clawed frog) tgt ARP48945_P050 TGT_XENTR transglycosylase) (Silurana tropicalis) 396 92.00% Queuine tRNA‐ribosyltransferase (EC 2.4.2.29) (Guanine insertion enzyme) (tRNA‐guanine tgt ARP48945_P050 TGT_XENLA transglycosylase) Xenopus laevis (African clawed frog) 396 92.00% Gamma‐aminobutyric acid A receptor subunit ARP34977_P050 E5LEX4_XENLA alpha‐1 (Fragment) Xenopus laevis (African clawed frog) 338 92.00% MAD, mothers against decapentaplegic P100621_T100 Q90YE5_XENLA homolog 3 (SMAD3) Xenopus laevis (African clawed frog) 425 100.00% Xenopus tropicalis (Western clawed frog) P100621_T100 Q68EP5_XENTR SMAD family member 3 (Silurana tropicalis) 425 100.00% ORF Names:GSPATT00029259001 EMBL CAK58223.1OrganismParamecium Xenopus tropicalis (Western clawed frog) tetraurelia ARP54750_P050 Q28DL5_XENTR G protein‐coupled receptor kinase 5 (Silurana tropicalis) 594 78.00% ORF Names:GSPATT00029259001 EMBL CAK58223.1OrganismParamecium Xenopus tropicalis (Western clawed frog) tetraurelia ARP54750_P050 Q6DF20_XENTR G protein‐coupled receptor kinase 4 (Silurana tropicalis) 575 78.00% ORF Names:GSPATT00029259001 EMBL CAK58223.1OrganismParamecium tetraurelia ARP54750_P050 Q6DCW4_XENLA Gprk4‐A‐prov protein Xenopus laevis (African clawed frog) 575 78.00% ORF Names:GSPATT00029259001 EMBL CAK58223.1OrganismParamecium tetraurelia ARP54750_P050 Q5XH04_XENLA Gprk4‐B‐prov protein Xenopus laevis (African clawed frog) 575 78.00% ORF Names:GSPATT00029259001 EMBL CAK58223.1OrganismParamecium tetraurelia ARP54750_P050 Q68F06_XENLA MGC83187 protein Xenopus laevis (African clawed frog) 575 78.00% ORF Names:GSPATT00029259001 EMBL CAK58223.1OrganismParamecium tetraurelia ARP54750_P050 Q4V7S7_XENLA LOC733256 protein (Fragment) Xenopus laevis (African clawed frog) 394 78.00% ARP46039_P050 Q6IP36_XENLA MGC78982 protein Xenopus laevis (African clawed frog) 335 92.00% ARP46039_P050 Q6DDQ6_XENLA Mthfd2‐prov protein Xenopus laevis (African clawed frog) 335 92.00% ARP46039_P050 Q2VPP2_XENLA MGC78982 protein Xenopus laevis (African clawed frog) 335 92.00% Xenopus tropicalis (Western clawed frog) ARP46039_P050 B3DL74_XENTR LOC100170462 protein (Silurana tropicalis) 335 92.00% ARP56162_P050 Q6IP36_XENLA MGC78982 protein Xenopus laevis (African clawed frog) 335 92.00% ARP56162_P050 Q6DDQ6_XENLA Mthfd2‐prov protein Xenopus laevis (African clawed frog) 335 92.00% ARP56162_P050 Q2VPP2_XENLA MGC78982 protein Xenopus laevis (African clawed frog) 335 92.00% Xenopus tropicalis (Western clawed frog) ARP56162_P050 B3DL74_XENTR LOC100170462 protein (Silurana tropicalis) 335 92.00% Xenopus tropicalis (Western clawed frog) unc93b1 ARP49979_T100 A4IHH1_XENTR Unc93b1 protein (Silurana tropicalis) 595 85.00% ORF Names:zgc:73210 EMBL AAI59222.1 ZFIN ZDB‐GENE‐040426‐ 1715OrganismDanio rerio (Zebrafish) (Brachydanio rerio) ARP52148_P050 Q6GP07_XENLA MGC80756 protein Xenopus laevis (African clawed frog) 230 100.00% ORF Names:zgc:73210 EMBL AAI59222.1 ZFIN ZDB‐GENE‐040426‐ 1715OrganismDanio rerio (Zebrafish) Xenopus tropicalis (Western clawed frog) (Brachydanio rerio) ARP52148_P050 Q28GL1_XENTR Lysophospholipase I (Silurana tropicalis) 230 100.00% ORF Names:zgc:73210 EMBL AAI59222.1 ZFIN ZDB‐GENE‐040426‐ 1715OrganismDanio rerio (Zebrafish) Xenopus tropicalis (Western clawed frog) (Brachydanio rerio) ARP52148_P050 Q6DJB2_XENTR Lysophospholipase II (Silurana tropicalis) 230 92.00% ORF Names:zgc:73210 EMBL AAI59222.1 ZFIN ZDB‐GENE‐040426‐ 1715OrganismDanio rerio (Zebrafish) (Brachydanio rerio) ARP52148_P050 Q7ZXQ6_XENLA MGC52664 protein Xenopus laevis (African clawed frog) 231 76.00% ORF Names:zgc:73210 EMBL AAI59222.1 ZFIN ZDB‐GENE‐040426‐ 1715OrganismDanio rerio (Zebrafish) Xenopus tropicalis (Western clawed frog) (Brachydanio rerio) ARP52148_P050 Q6P346_XENTR Putative uncharacterized protein MGC75683 (Silurana tropicalis) 231 76.00% (EC 3.5.1.15) (‐2) Xenopus tropicalis (Western clawed frog) aspa ARP56073_P050 ACY2_XENTR (ACY‐2) (Silurana tropicalis) 313 92.00% KPR4 ARP41448_P050 Q7ZXR6_XENLA Prps1 protein (Fragment) Xenopus laevis (African clawed frog) 326 100.00% Similar to phosphoribosyl pyrophosphate Xenopus tropicalis (Western clawed frog) KPR4 ARP41448_P050 Q6P830_XENTR synthetase 1 (Silurana tropicalis) 318 100.00% KPR4 ARP41448_P050 Q6AZI9_XENLA Prps1 protein Xenopus laevis (African clawed frog) 318 100.00% Ribose‐phosphate pyrophosphokinase 2 (EC 2.7.6.1) (Phosphoribosyl pyrophosphate Xenopus tropicalis (Western clawed frog) KPR4 ARP41448_P050 PRPS2_XENTR synthase II) (PRS‐II) (Silurana tropicalis) 318 100.00% Ribose‐phosphate pyrophosphokinase 2 (EC 2.7.6.1) (Phosphoribosyl pyrophosphate KPR4 ARP41448_P050 PRPS2_XENLA synthase II) (PRS‐II) Xenopus laevis (African clawed frog) 318 100.00% Abhydrolase domain‐containing protein 13 LOC100049138 ARP50137_P050 ABHDD_XENLA (EC 3.‐.‐.‐) Xenopus laevis (African clawed frog) 336 78.00% Xenopus tropicalis (Western clawed frog) LOC100049138 ARP50137_P050 A9JTX5_XENTR LOC100127876 protein (Silurana tropicalis) 336 78.00% LOC100049138 ARP50137_P050 A4IFW9_XENLA LOC100049138 protein Xenopus laevis (African clawed frog) 336 78.00% cbx8a ARP34599_P050 Q5M982_XENLA LOC496172 protein Xenopus laevis (African clawed frog) 361 92.00% Xenopus tropicalis (Western clawed frog) cbx8a ARP34599_P050 Q0IIR6_XENTR Chromobox homolog 8 (Silurana tropicalis) 362 92.00% cbx8a ARP34599_P050 Q6NTQ8_XENLA MGC83092 protein Xenopus laevis (African clawed frog) 360 85.00% Nuclear receptor subfamily 4 group A member Xenopus tropicalis (Western clawed frog) ARP38754_P050 NR4A2_XENTR 2 (Silurana tropicalis) 591 100.00% Zinc finger protein ubi‐d4 A (Apoptosis response zinc finger protein A) (Protein dpf2l ARP38769_P050 REQUA_XENLA requiem A) (xReq A) Xenopus laevis (African clawed frog) 388 90.00% Xenopus tropicalis (Western clawed frog) il11ra ARP46465_P050 A4IHR2_XENTR Il11ra protein (Silurana tropicalis) 395 84.00% Xenopus tropicalis (Western clawed frog) HEM1 ARP41889_P050 Q6DF22_XENTR Aminolevulinate, delta‐, synthase 2 (Silurana tropicalis) 608 92.00% HEM1 ARP41889_P050 Q68F30_XENLA MGC82115 protein Xenopus laevis (African clawed frog) 609 92.00% HEM1 ARP41889_P050 Q5XG49_XENLA LOC495283 protein (Fragment) Xenopus laevis (African clawed frog) 599 92.00% HEM1 ARP41889_P050 Q6PAZ6_XENLA MGC68700 protein Xenopus laevis (African clawed frog) 621 85.00%

HEM1 ARP41889_P050 Q6EE56_XENLA Aminolevulinic acid synthase 1 (Fragment) Xenopus laevis (African clawed frog) 344 85.00% HEM1 ARP41889_P050 Q6DKE7_XENLA MGC81838 protein Xenopus laevis (African clawed frog) 623 85.00% Xenopus tropicalis (Western clawed frog) HEM1 ARP41889_P050 Q66JC7_XENTR MGC79710 protein (Silurana tropicalis) 628 85.00% Xenopus tropicalis (Western clawed frog) HEM1 ARP41889_P050 Q28HS9_XENTR Aminolevulinate, delta‐, synthase 1 (Silurana tropicalis) 628 85.00%

ARP46156_P050 A2RVA9_XENLA Putative uncharacterized protein (Fragment) Xenopus laevis (African clawed frog) 466 92.00% Structural maintenance of chromosomes protein 2 (SMC protein 2) (SMC‐2) (Chromosome assembly protein XCAP‐E) ARP46156_P050 SMC2_XENLA (Chromosome‐associated protein E) Xenopus laevis (African clawed frog) 1203 92.00% Lhx8 ARP47491_T100 Q6PF48_XENLA MGC68912 protein Xenopus laevis (African clawed frog) 282 78.00% Xenopus tropicalis (Western clawed frog) Lhx8 ARP47491_T100 Q28CD2_XENTR LIM homeobox 7/8 (LIM homeobox 8) (Silurana tropicalis) 374 78.00% Epb4.1 ARP42746_P050 Q6DCU8_XENLA LOC397741 protein Xenopus laevis (African clawed frog) 800 83.00% Epb4.1 ARP42746_P050 41_XENLA Cytoskeletal protein 4.1 (Band 4.1) Xenopus laevis (African clawed frog) 801 83.00% Use1 ARP34134_P050 Q2NLA4_XENLA MGC131274 protein Xenopus laevis (African clawed frog) 259 84.00% Xenopus tropicalis (Western clawed frog) Use1 ARP34134_P050 B1H3E7_XENTR LOC100145610 protein (Silurana tropicalis) 259 84.00% cdca4 ARP50622_T100 Q6DFF1_XENLA Cdca4‐prov protein Xenopus laevis (African clawed frog) 246 78.00% cdca4 ARP50622_T100 Q5PQ11_XENLA LOC496018 protein Xenopus laevis (African clawed frog) 246 78.00% Xenopus tropicalis (Western clawed frog) cdca4 ARP50622_T100 Q0P4X9_XENTR Putative uncharacterized protein LOC549403 (Silurana tropicalis) 248 76.00% Xenopus tropicalis (Western clawed frog) KIF22 ARP33919_P050 Q28IW7_XENTR Novel protein similar to KIF22 (Silurana tropicalis) 484 75.00% Xenopus tropicalis (Western clawed frog) KIF22 ARP33919_P050 KIF22_XENTR Kinesin‐like protein KIF22 (Chromokinesin kid) (Silurana tropicalis) 639 75.00%

ORF Names:GSPATT00030579001 MGC53867 protein (Proliferating cell nuclear EMBL antigen subtype1) (Proliferating cell nuclear CAK59941.1OrganismParamecium antigen subtype2) (Proliferating cell nuclear tetraurelia AVARP03018_T100 Q9I893_XENLA antigen subtype3) Xenopus laevis (African clawed frog) 261 100.00% ORF Names:GSPATT00030579001 EMBL CAK59941.1OrganismParamecium tetraurelia AVARP03018_T100 Q6PF20_XENLA Pcna‐A protein Xenopus laevis (African clawed frog) 261 100.00% ORF Names:GSPATT00030579001 EMBL CAK59941.1OrganismParamecium Xenopus tropicalis (Western clawed frog) tetraurelia AVARP03018_T100 Q66KJ8_XENTR Pcna protein (Silurana tropicalis) 261 100.00% ORF Names:GSPATT00030579001 EMBL CAK59941.1OrganismParamecium tetraurelia AVARP03018_T100 B2L5B1_XENBO Proliferating cell nuclear antigen (Fragment) Xenopus borealis (Kenyan clawed frog) 31 100.00% ORF Names:GSPATT00030579001 EMBL CAK59941.1OrganismParamecium Proliferating cell nuclear antigen (PCNA) tetraurelia AVARP03018_T100 PCNA_XENLA (Cyclin) Xenopus laevis (African clawed frog) 261 100.00% ORF Names:GSPATT00026644001 EMBL Probable cytosolic iron‐sulfur protein CAK94320.1OrganismParamecium assembly protein ciao1 (WD repeat‐containing Xenopus tropicalis (Western clawed frog) tetraurelia ARP34400_P050 CIAO1_XENTR protein 39) (Silurana tropicalis) 333 92.00%

Mediator of RNA polymerase II transcription Xenopus tropicalis (Western clawed frog) MED16 ARP31452_P050 MED16_XENTR subunit 16 (Mediator complex subunit 16) (Silurana tropicalis) 828 85.00% Mediator of RNA polymerase II transcription MED16 ARP31452_P050 MED16_XENLA subunit 16 (Mediator complex subunit 16) Xenopus laevis (African clawed frog) 697 85.00% Xenopus tropicalis (Western clawed frog) gabrb2 ARP34986_P050 A4IIN3_XENTR LOC100125027 protein (Silurana tropicalis) 474 100.00% Xenopus tropicalis (Western clawed frog) gabrb2 ARP34986_P050 A4IIK0_XENTR Gabrb3 protein (Silurana tropicalis) 475 100.00%

ORF Names:RP71‐39B20.3‐001 EMBL CAQ14485.1OrganismDanio rerio Xenopus tropicalis (Western clawed frog) (Zebrafish) (Brachydanio rerio) ARP35094_T100 Q0P4T6_XENTR Putative uncharacterized protein MGC145919 (Silurana tropicalis) 540 92.00%

ORF Names:RP71‐39B20.3‐001 EMBL CAQ14485.1OrganismDanio rerio Xenopus tropicalis (Western clawed frog) (Zebrafish) (Brachydanio rerio) ARP35094_T100 B1H397_XENTR LOC100145581 protein (Silurana tropicalis) 231 92.00% Xenopus tropicalis (Western clawed frog) ARP51212_T100 B4F6H1_XENTR Putative uncharacterized protein LOC548748 (Silurana tropicalis) 75 100.00% ARP51212_T100 BRK1A_XENLA Probable protein BRICK1‐A Xenopus laevis (African clawed frog) 75 100.00% ARP51212_T100 BRK1B_XENLA Probable protein BRICK1‐B Xenopus laevis (African clawed frog) 75 92.00% ZNF131 ARP47576_P050 Q32NJ9_XENLA MGC131094 protein Xenopus laevis (African clawed frog) 577 85.00% ADAM9 ARP46373_P050 O42595_XENLA Metalloprotease‐disintegrin Xenopus laevis (African clawed frog) 873 92.00% ADAM9 ARP46373_P050 B7ZRU6_XENLA Adam9‐A protein Xenopus laevis (African clawed frog) 869 92.00% Xenopus tropicalis (Western clawed frog) ADAM9 ARP46373_P050 E2ICL5_XENTR Metalloproteinase ADAM9 (Silurana tropicalis) 863 92.00%

ORF Names:TRIADDRAFT_28466 EMBL Ribosome maturation protein SBDS EDV22481.1OrganismTrichoplax (Shwachman‐Bodian‐Diamond syndrome Xenopus tropicalis (Western clawed frog) adhaerens (Trichoplax reptans) ARP45721_T100 SBDS_XENTR protein homolog) (Silurana tropicalis) 250 92.00%

ORF Names:TRIADDRAFT_28466 EMBL Ribosome maturation protein SBDS EDV22481.1OrganismTrichoplax (Shwachman‐Bodian‐Diamond syndrome adhaerens (Trichoplax reptans) ARP45721_T100 SBDS_XENLA protein homolog) Xenopus laevis (African clawed frog) 250 92.00% Alcohol dehydrogenase 5 (Class III), chi Xenopus tropicalis (Western clawed frog) ARP41789_T100 Q5HZT1_XENTR polypeptide (Hypothetical LOC497007) (Silurana tropicalis) 376 76.00% NADH dehydrogenase [ubiquinone] 1 subunit ndufc2 ARP46472_P050 A3KMU9_XENLA C2 Xenopus laevis (African clawed frog) 110 90.00% Xenopus tropicalis (Western clawed frog) nr1d1 ARP38568_T100 A4IIE9_XENTR Nr1d1 protein (Silurana tropicalis) 522 92.00% nr1d1 ARP38568_T100 Q6GND0_XENLA MGC82865 protein Xenopus laevis (African clawed frog) 519 84.00% Xenopus tropicalis (Western clawed frog) LRRC28 ARP52690_P050 LRC28_XENTR Leucine‐rich repeat‐containing protein 28 (Silurana tropicalis) 367 100.00% LOC445879 ARP46838_T100 Q6DDD8_XENLA LOC445879 protein (Fragment) Xenopus laevis (African clawed frog) 133 92.00% LOC445879 ARP46838_T100 Q2TAV9_XENLA Putative uncharacterized protein Xenopus laevis (African clawed frog) 622 92.00% Mannose‐1‐phosphate guanyltransferase beta (EC 2.7.7.13) (GDP‐mannose pyrophosphorylase B) (GTP‐mannose‐1‐ Xenopus tropicalis (Western clawed frog) gmppb‐b ARP48882_T100 GMPPB_XENTR phosphate guanylyltransferase beta) (Silurana tropicalis) 360 85.00%

Mannose‐1‐phosphate guanyltransferase beta‐ B (EC 2.7.7.13) (GDP‐mannose pyrophosphorylase B‐B) (GTP‐mannose‐1‐ gmppb‐b ARP48882_T100 GMPBB_XENLA phosphate guanylyltransferase beta‐B) Xenopus laevis (African clawed frog) 360 85.00%

Mannose‐1‐phosphate guanyltransferase beta‐ A (EC 2.7.7.13) (GDP‐mannose pyrophosphorylase B‐A) (GTP‐mannose‐1‐ gmppb‐b ARP48882_T100 GMPBA_XENLA phosphate guanylyltransferase beta‐A) Xenopus laevis (African clawed frog) 360 85.00% ORF Names:ACLA_049400 EMBL EAW10468.1OrganismAspergillus Xenopus tropicalis (Western clawed frog) clavatus AVARP09038_P050 B1H3C4_XENTR LOC496794 protein (Silurana tropicalis) 674 100.00% ORF Names:ACLA_049400 EMBL EAW10468.1OrganismAspergillus clavatus AVARP09038_P050 Q6GNA6_XENLA MGC82921 protein Xenopus laevis (African clawed frog) 673 86.00% C24H18ORF10 ARP55266_P050 Q66KV1_XENLA MGC85408 protein Xenopus laevis (African clawed frog) 277 92.00% Xenopus tropicalis (Western clawed frog) ARP35590_T100 B2GU78_XENTR LOC100158521 protein (Silurana tropicalis) 583 90.00% ARP35590_T100 A8WH49_XENLA LOC100127255 protein (Fragment) Xenopus laevis (African clawed frog) 498 90.00% Na+‐glucose cotransporter type 1 (SGLT‐1)‐ SLC5A1 ARP44083_P050 O42135_XENLA like protein Xenopus laevis (African clawed frog) 673 100.00% Na+‐glucose cotransporter type 1 (SGLT‐1)‐ SLC5A1 ARP44083_P050 B7ZRV7_XENLA like protein Xenopus laevis (African clawed frog) 673 100.00% Na+‐glucose cotransporter type 1 (SGLT‐1)‐ SLC5A1 ARP44083_P050 B7ZRV5_XENLA like protein Xenopus laevis (African clawed frog) 673 100.00% ORF Names:GSPATT00030645001 EMBL CAK60007.1OrganismParamecium tetraurelia ARP57876_P050 Q9YH15_XENLA Transcription factor XHEN1 Xenopus laevis (African clawed frog) 128 100.00% ORF Names:GSPATT00030645001 EMBL CAK60007.1OrganismParamecium tetraurelia ARP57876_P050 Q5XGK3_XENLA LOC495280 protein Xenopus laevis (African clawed frog) 128 100.00% ORF Names:GSPATT00030645001 EMBL CAK60007.1OrganismParamecium Xenopus tropicalis (Western clawed frog) tetraurelia ARP57876_P050 B5DEA1_XENTR Putative uncharacterized protein (Silurana tropicalis) 388 84.00% ORF Names:GSPATT00030645001 EMBL CAK60007.1OrganismParamecium T‐cell acute lymphocytic leukemia protein 1 tetraurelia ARP57876_P050 TAL1_XENLA (TAL‐1) (Stem cell leukemia protein SCL) (xSCL) Xenopus laevis (African clawed frog) 394 84.00% Xenopus tropicalis (Western clawed frog) MYC ARP30292_P050 Q6P1T1_XENTR Putative uncharacterized protein MGC76254 (Silurana tropicalis) 418 100.00% MYC ARP30292_P050 Q6NRN4_XENLA Myc protein Xenopus laevis (African clawed frog) 420 100.00% MYC ARP30292_P050 Q546B4_XENLA MYC oncprotein (Fragment) Xenopus laevis (African clawed frog) 83 100.00% MYC ARP30292_P050 Q32U00_XENLA C‐myc (Fragment) Xenopus laevis (African clawed frog) 141 100.00% MYC ARP30292_P050 Q2TAU1_XENLA Myc‐a protein Xenopus laevis (African clawed frog) 419 100.00%

MYC ARP30292_P050 MYCB_XENLA Transcriptional regulator Myc‐B (c‐Myc II) Xenopus laevis (African clawed frog) 420 100.00% MYC ARP30292_P050 MYC1_XENLA Transcriptional regulator Myc‐A (c‐Myc I) Xenopus laevis (African clawed frog) 419 100.00% MYC ARP30292_P050 Q7ZYK5_XENLA Mycn‐prov protein Xenopus laevis (African clawed frog) 439 100.00% V‐myc myelocytomatosis viral related Xenopus tropicalis (Western clawed frog) MYC ARP30292_P050 Q6DEU8_XENTR oncogene, neuroblastoma derived (Silurana tropicalis) 445 100.00% MYC ARP30292_P050 B3DLS5_XENLA Putative uncharacterized protein Xenopus laevis (African clawed frog) 437 100.00% MYC ARP30292_P050 MYCN_XENLA N‐myc protein Xenopus laevis (African clawed frog) 437 100.00% LSM2 homolog, U6 small nuclear RNA associated (LSM2 homolog, U6 small nuclear Xenopus tropicalis (Western clawed frog) LSM2 ARP40963_T100 Q5BL46_XENTR RNA associated (S. cerevisiae)) (Silurana tropicalis) 95 92.00% LSM2 ARP40963_T100 Q52KE0_XENLA Lsm2 protein Xenopus laevis (African clawed frog) 95 92.00% dll1 ARP46625_P050 Q91902_XENLA X‐Delta‐1 Xenopus laevis (African clawed frog) 721 100.00% Xenopus tropicalis (Western clawed frog) dll1 ARP46625_P050 A4IHM4_XENTR Dll1 protein (Silurana tropicalis) 721 92.00% Xenopus tropicalis (Western clawed frog) kcmf1 ARP32921_P050 B1H326_XENTR Kcmf1 protein (Silurana tropicalis) 381 92.00% kcmf1 ARP32921_P050 KCMF1_XENLA E3 ubiquitin‐protein ligase KCMF1 (EC 6.3.2.‐) Xenopus laevis (African clawed frog) 381 92.00% TPM3 ARP41392_T100 Q9YH30_XENLA Alpha tropomyosin (Fragment) Xenopus laevis (African clawed frog) 80 100.00% TPM3 ARP41392_T100 Q91726_XENLA Cardiac tropomyosin Xenopus laevis (African clawed frog) 284 100.00% TPM3 ARP41392_T100 Q7SYY4_XENLA MGC64401 protein Xenopus laevis (African clawed frog) 284 100.00% TPM3 ARP41392_T100 Q6IP24_XENLA Putative uncharacterized protein Xenopus laevis (African clawed frog) 284 100.00% Xenopus tropicalis (Western clawed frog) TPM3 ARP41392_T100 B1H2X3_XENTR Tpm1 protein (Silurana tropicalis) 284 100.00% Xenopus tropicalis (Western clawed frog) TPM3 ARP41392_T100 B0BMH6_XENTR Tpm1 protein (Silurana tropicalis) 284 100.00% Tropomyosin alpha‐1 chain (Alpha‐ TPM3 ARP41392_T100 TPM1_XENLA tropomyosin) (Tropomyosin‐1) Xenopus laevis (African clawed frog) 284 100.00% Fast skeletal muscle beta‐tropomyosin TPM3 ARP41392_T100 Q91706_XENLA (Putative uncharacterized protein) Xenopus laevis (African clawed frog) 284 78.00% TPM3 ARP41392_T100 Q7ZYU5_XENLA LOC398674 protein Xenopus laevis (African clawed frog) 284 78.00% TPM3 ARP41392_T100 Q7SXS3_XENLA LOC398674 protein (Fragment) Xenopus laevis (African clawed frog) 302 78.00% TPM3 ARP41392_T100 Q6IRB0_XENLA LOC398674 protein (Fragment) Xenopus laevis (African clawed frog) 298 78.00% P100612_P050 Q9DFC1_XENLA Homeobox protein XHox11 Xenopus laevis (African clawed frog) 312 85.00% ORF Names:zgc:123349 EMBL AAI52591.1 ZFIN ZDB‐GENE‐051113‐ 160OrganismDanio rerio (Zebrafish) (Brachydanio rerio) ARP56506_P050 Q7ZT10_XENLA MGC53561 protein Xenopus laevis (African clawed frog) 412 92.00% ORF Names:zgc:123349 EMBL AAI52591.1 ZFIN ZDB‐GENE‐051113‐ 160OrganismDanio rerio (Zebrafish) Xenopus tropicalis (Western clawed frog) (Brachydanio rerio) ARP56506_P050 Q5BKM5_XENTR Rad23b protein (Silurana tropicalis) 416 92.00% ORF Names:zgc:123349 EMBL AAI52591.1 ZFIN ZDB‐GENE‐051113‐ 160OrganismDanio rerio (Zebrafish) (Brachydanio rerio) ARP56506_P050 Q505M5_XENLA MGC115064 protein Xenopus laevis (African clawed frog) 419 92.00% ORF Names:zgc:123349 EMBL AAI52591.1 ZFIN ZDB‐GENE‐051113‐ 160OrganismDanio rerio (Zebrafish) Xenopus tropicalis (Western clawed frog) (Brachydanio rerio) ARP56506_P050 B3DLQ6_XENTR LOC100170527 protein (Silurana tropicalis) 404 84.00% Xenopus tropicalis (Western clawed frog) LOC568719 ARP40017_P050 B2GUB8_XENTR Znf800 protein (Silurana tropicalis) 690 78.00% ORF Names:GSPATT00034320001 EMBL CAK64843.1OrganismParamecium Xenopus tropicalis (Western clawed frog) tetraurelia ARP52954_P050 Q28EA9_XENTR Hepatocellular carcinoma‐related HCRP1 (Silurana tropicalis) 382 91.00% ORF Names:GSPATT00034320001 EMBL CAK64843.1OrganismParamecium tetraurelia ARP52954_P050 Q0IHC8_XENLA MGC115147 protein Xenopus laevis (African clawed frog) 380 91.00% ORF Names:GSPATT00034320001 EMBL CAK64843.1OrganismParamecium tetraurelia ARP52954_P050 A1L2J9_XENLA LOC100036869 protein Xenopus laevis (African clawed frog) 379 91.00% ORF Names:GSPATT00014863001 EMBL CAK79956.1OrganismParamecium tetraurelia ARP44709_P050 Q6NRH6_XENLA MGC83809 protein Xenopus laevis (African clawed frog) 509 100.00% ORF Names:GSPATT00014863001 EMBL CAK79956.1OrganismParamecium Transmembrane and coiled‐coil domain family Xenopus tropicalis (Western clawed frog) tetraurelia ARP44709_P050 Q0IHU7_XENTR 2 (Silurana tropicalis) 725 100.00% ORF Names:GSPATT00014863001 EMBL CAK79956.1OrganismParamecium tetraurelia ARP44709_P050 Q6GQA5_XENLA Fibronectin protein Xenopus laevis (African clawed frog) 2481 100.00% ORF Names:GSPATT00014863001 EMBL CAK79956.1OrganismParamecium tetraurelia ARP44709_P050 FINC_XENLA Fibronectin (FN) Xenopus laevis (African clawed frog) 2481 100.00% TRIP4 ARP35908_T100 Q6GQZ5_XENLA MGC83197 protein Xenopus laevis (African clawed frog) 567 92.00% Xenopus tropicalis (Western clawed frog) TRIP4 ARP35908_T100 B1H319_XENTR LOC100145534 protein (Silurana tropicalis) 443 92.00% Xenopus tropicalis (Western clawed frog) ARP51595_P050 Q28CS9_XENTR Novel zinc finger protein (Silurana tropicalis) 583 92.00% znf148 ARP51595_P050 Q6DF71_XENLA MGC84640 protein Xenopus laevis (African clawed frog) 434 85.00% znf148 ARP51595_P050 Q6AX11_XENLA Znf420 protein Xenopus laevis (African clawed frog) 980 85.00% znf148 ARP51595_P050 Q6NRD9_XENLA MGC83896 protein Xenopus laevis (African clawed frog) 723 100.00% Xenopus tropicalis (Western clawed frog) TuCav‐beta ARP35580_P050 B5DDZ7_XENTR Putative uncharacterized protein (Silurana tropicalis) 486 100.00% Voltage‐dependent calcium ion channel beta TuCav‐beta ARP35580_P050 Q9I8G7_XENLA subunit (Fragment) Xenopus laevis (African clawed frog) 135 92.00% Voltage‐dependent calcium channel beta TuCav‐beta ARP35580_P050 Q91630_XENLA subunit Xenopus laevis (African clawed frog) 484 92.00% Voltage‐dependent calcium channel beta TuCav‐beta ARP35580_P050 Q91629_XENLA subunit Xenopus laevis (African clawed frog) 484 92.00% Xenopus tropicalis (Western clawed frog) TuCav‐beta ARP35580_P050 B0JZD2_XENTR LOC100145181 protein (Silurana tropicalis) 484 92.00% Xenopus tropicalis (Western clawed frog) TuCav‐beta ARP35580_P050 B2GU78_XENTR LOC100158521 protein (Silurana tropicalis) 583 85.00% TuCav‐beta ARP35580_P050 A8WH49_XENLA LOC100127255 protein (Fragment) Xenopus laevis (African clawed frog) 498 85.00% ARP53620_P050 Q7ZWL0_XENLA Nup155‐prov protein Xenopus laevis (African clawed frog) 1388 78.00% Polymerase (RNA) III (DNA directed) Xenopus tropicalis (Western clawed frog) ARP48705_P050 Q6P325_XENTR polypeptide F, 39 kDa (Silurana tropicalis) 314 78.00% Galnt13 ARP50222_P050 Q6GM51_XENLA MGC83963 protein Xenopus laevis (African clawed frog) 556 85.00% ORF Names:SCB49_03254 EMBL EDM45105.1Organismunidentified eubacterium SCB49 ARP44536_P050 Q7ZYM5_XENLA Sdcbp protein (Sdcbp‐prov protein) Xenopus laevis (African clawed frog) 295 85.00% ORF Names:SCB49_03254 EMBL EDM45105.1Organismunidentified Xenopus tropicalis (Western clawed frog) eubacterium SCB49 ARP44536_P050 Q6DFR3_XENTR Syndecan binding protein (Syntenin) (Silurana tropicalis) 295 85.00% ORF Names:SCB49_03254 EMBL EDM45105.1Organismunidentified eubacterium SCB49 ARP44536_P050 Q66JA3_XENLA MGC81274 protein Xenopus laevis (African clawed frog) 295 85.00% ORF Names:SCB49_03254 EMBL EDM45105.1Organismunidentified eubacterium SCB49 ARP44536_P050 Q801P2_XENLA MGC52622 protein Xenopus laevis (African clawed frog) 290 84.00% Xenopus tropicalis (Western clawed frog) ARP47559_T100 A0JP90_XENTR Mafk protein (Silurana tropicalis) 156 85.00% ARP47559_T100 Q5U4S3_XENLA LOC495449 protein Xenopus laevis (African clawed frog) 148 85.00% Xenopus tropicalis (Western clawed frog) ARP47559_T100 MAF_XENTR Transcription factor Maf (Silurana tropicalis) 352 78.00% Xenopus tropicalis (Western clawed frog) ARP47559_T100 MAFA_XENTR Transcription factor MafA (Silurana tropicalis) 289 78.00%

ORF Names:37512OrganismMonosiga brevicollis (Choanoflagellate) ARP37729_T100 Q3B8F0_XENLA MGC131240 protein Xenopus laevis (African clawed frog) 148 100.00%

ORF Names:37512OrganismMonosiga Xenopus tropicalis (Western clawed frog) brevicollis (Choanoflagellate) ARP37729_T100 Q28IW0_XENTR Endothelial differentiation‐related factor 1 (Silurana tropicalis) 148 100.00%

ORF Names:37512OrganismMonosiga Endothelial differentiation‐related factor 1 brevicollis (Choanoflagellate) ARP37729_T100 EDF1_XENLA homolog (EDF‐1) Xenopus laevis (African clawed frog) 147 100.00%

Zfp46 ARP33527_T100 ZO26_XENLA Oocyte zinc finger protein XlCOF26 (Fragment) Xenopus laevis (African clawed frog) 196 84.00% Zinc finger protein Xfin (Xenopus fingers Zfp46 ARP33527_T100 XFIN_XENLA protein) (Xfin) Xenopus laevis (African clawed frog) 1350 90.00% Xenopus tropicalis (Western clawed frog) Zfp46 ARP33527_T100 B3DLU5_XENTR LOC100170545 protein (Silurana tropicalis) 302 90.00% Xenopus tropicalis (Western clawed frog) Zfp46 ARP33527_T100 Q28DU9_XENTR Novel zinc finger protein (Silurana tropicalis) 248 90.00% Xenopus tropicalis (Western clawed frog) Zfp46 ARP33527_T100 A9ULJ8_XENTR LOC100135213 protein (Silurana tropicalis) 271 90.00% oat ARP48135_T100 Q98TS5_XENLA Ornithine aminotransferase Xenopus laevis (African clawed frog) 439 100.00% oat ARP48135_T100 Q7ZX40_XENLA Oat‐prov protein Xenopus laevis (African clawed frog) 439 100.00% oat ARP48135_T100 Q6DE30_XENLA Oat‐prov protein Xenopus laevis (African clawed frog) 439 100.00% Ornithine aminotransferase (Ornithine Xenopus tropicalis (Western clawed frog) oat ARP48135_T100 Q28FA4_XENTR aminotransferase (Gyrate atrophy)) (Silurana tropicalis) 439 100.00% Xenopus tropicalis (Western clawed frog) PDGFB ARP58509_P050 B1H1E3_XENTR Pdgfb protein (Silurana tropicalis) 240 100.00% ORF Names:EDI_135520 EMBL EDR27098.1OrganismEntamoeba dispar SAW760 AVARP01017_P050 Q9PW31_XENLA RAC1 protein (Rac GTPase) Xenopus laevis (African clawed frog) 192 100.00% ORF Names:EDI_135520 EMBL EDR27098.1OrganismEntamoeba Cdc42 protein (Rho GTPase Cdc42) (Rho dispar SAW760 AVARP01017_P050 Q9DDV6_XENLA family small GTP binding protein cdc42) Xenopus laevis (African clawed frog) 191 100.00% ORF Names:EDI_135520 EMBL EDR27098.1OrganismEntamoeba dispar SAW760 AVARP01017_P050 Q6GP43_XENLA MGC80698 protein Xenopus laevis (African clawed frog) 192 100.00% ORF Names:EDI_135520 EMBL EDR27098.1OrganismEntamoeba Ras‐related C3 botulinum toxin substrate 1 Xenopus tropicalis (Western clawed frog) dispar SAW760 AVARP01017_P050 Q6GL60_XENTR (Rho family, small GTP binding protein Rac1) (Silurana tropicalis) 192 100.00% ORF Names:EDI_135520 EMBL EDR27098.1OrganismEntamoeba Cell division cycle 42 (GTP binding protein, Xenopus tropicalis (Western clawed frog) dispar SAW760 AVARP01017_P050 Q66JI0_XENTR 25kDa) (Silurana tropicalis) 191 100.00%

Novel protein similar to ras‐related C3 botulinum toxin substrate 1 (Rho family, small ORF Names:EDI_135520 EMBL GTP binding protein Rac1) (Ras‐related C3 EDR27098.1OrganismEntamoeba botulinum toxin substrate 2 (Rho family, small Xenopus tropicalis (Western clawed frog) dispar SAW760 AVARP01017_P050 Q5M8J2_XENTR GTP binding protein Rac2)) (Silurana tropicalis) 192 100.00% ORF Names:EDI_135520 EMBL EDR27098.1OrganismEntamoeba dispar SAW760 AVARP01017_P050 Q58E25_XENLA MGC114731 protein Xenopus laevis (African clawed frog) 192 100.00% ORF Names:EDI_135520 EMBL EDR27098.1OrganismEntamoeba Cell division cycle 42 (GTP binding protein, Xenopus tropicalis (Western clawed frog) dispar SAW760 AVARP01017_P050 Q28BZ0_XENTR 25kDa) (Silurana tropicalis) 191 100.00% ORF Names:EDI_135520 EMBL EDR27098.1OrganismEntamoeba Xenopus tropicalis (Western clawed frog) dispar SAW760 AVARP01017_P050 A4IHY4_XENTR Rac3 protein (Silurana tropicalis) 192 100.00% ORF Names:GSPATT00006099001 EMBL CAK64246.1OrganismParamecium tetraurelia ARP51655_P050 Q3KQ22_XENLA MGC131085 protein Xenopus laevis (African clawed frog) 317 85.00% AK1 ARP48148_P050 Q6GQF9_XENLA Ak1a protein Xenopus laevis (African clawed frog) 194 84.00% Xenopus tropicalis (Western clawed frog) AK1 ARP48148_P050 Q6DFN0_XENTR Adenylate kinase 1 (Silurana tropicalis) 194 84.00% AK1 ARP48148_P050 Q66J33_XENLA Ak1b protein Xenopus laevis (African clawed frog) 212 84.00% ica1 ARP54742_P050 Q8AVX4_XENLA Ica1‐prov protein Xenopus laevis (African clawed frog) 512 92.00% ica1 ARP54742_P050 Q6NTK0_XENLA MGC83241 protein Xenopus laevis (African clawed frog) 516 92.00% Xenopus tropicalis (Western clawed frog) ica1 ARP54742_P050 Q28DQ1_XENTR Islet cell autoantigen 1 (Silurana tropicalis) 515 92.00% Xenopus tropicalis (Western clawed frog) ica1 ARP54742_P050 A4II33_XENTR Ica1 protein (Silurana tropicalis) 530 92.00% ARP34089_T100 Q7SZ88_XENLA Ube2n‐prov protein Xenopus laevis (African clawed frog) 152 100.00% Ubiquitin‐conjugating enzyme E2N (UBC13 homolog) (Ubiquitin‐conjugating enzyme E2N Xenopus tropicalis (Western clawed frog) ARP34089_T100 Q6P349_XENTR (UBC13 homolog, yeast)) (Silurana tropicalis) 152 100.00% Xenopus tropicalis (Western clawed frog) LOC100127554 ARP53726_P050 B1H2S5_XENTR LOC100127554 protein (Silurana tropicalis) 575 85.00% LOC100127554 ARP53726_P050 A9JS44_XENLA LOC100127303 protein (Fragment) Xenopus laevis (African clawed frog) 333 85.00% Xenopus tropicalis (Western clawed frog) LOC100127554 ARP53726_P050 A7MC58_XENTR LOC100127554 protein (Fragment) (Silurana tropicalis) 331 85.00% Upstream stimulatory factor 1 (USF) (B1 usf1‐bd ARP34707_P050 USF1_XENBO factor) (SPF1) Xenopus borealis (Kenyan clawed frog) 307 84.00% Xenopus tropicalis (Western clawed frog) usf1‐bd ARP34707_P050 A4IH39_XENTR Usf1 protein (Silurana tropicalis) 309 83.00% usf1‐bd ARP34707_P050 Q4V7Y6_XENLA MGC114919 protein Xenopus laevis (African clawed frog) 299 76.00% Xenopus tropicalis (Western clawed frog) TCP11L2 ARP55541_P050 B1WAZ9_XENTR LOC100145732 protein (Silurana tropicalis) 512 85.00%

Solute carrier family 23 member 2 (Na(+)/L‐ ascorbic acid transporter 2) (Sodium‐ Xenopus tropicalis (Western clawed frog) ARP43902_P050 S23A2_XENTR dependent transporter 2) (Silurana tropicalis) 649 100.00% Xenopus tropicalis (Western clawed frog) ARP38596_T100 B0JZE3_XENTR Foxg1 protein (Silurana tropicalis) 432 100.00% Forkhead box protein G1 (FoxG1) (Brain factor 1) (BF‐1) (xBF‐1) (xBF1) (Forkhead protein 4) ARP38596_T100 FOXG1_XENLA (FKH‐4) (xFKH4) Xenopus laevis (African clawed frog) 436 100.00% MIS1 ARP46147_P050 Q7ZXF4_XENLA Mthfd1‐prov protein Xenopus laevis (African clawed frog) 934 92.00%

Methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1, methenyltetrahydrofolate cyclohydrolase, Xenopus tropicalis (Western clawed frog) MIS1 ARP46147_P050 Q66JJ9_XENTR formyltetrahydrofolate synthetase (Silurana tropicalis) 934 92.00%

Methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1, methenyltetrahydrofolate cyclohydrolase, Xenopus tropicalis (Western clawed frog) MIS1 ARP46147_P050 Q28BS7_XENTR formyltetrahydrofolate synthetase (Silurana tropicalis) 934 92.00% Xenopus tropicalis (Western clawed frog) MIS1 ARP46147_P050 B0JZH4_XENTR LOC100145211 protein (Silurana tropicalis) 955 85.00% Xenopus tropicalis (Western clawed frog) ARP43498_P050 Q28BW8_XENTR Ring finger protein 127 (Silurana tropicalis) 771 78.00%

ORF Names:v1g101020OrganismNematostel la vectensis (Starlet sea anemone) ARP51935_P050 Q8AVV3_XENLA Ap3s1‐prov protein Xenopus laevis (African clawed frog) 193 85.00% ORF Names:v1g101020OrganismNematostel Xenopus tropicalis (Western clawed frog) la vectensis (Starlet sea anemone) ARP51935_P050 Q6DDC0_XENTR MGC89782 protein (Silurana tropicalis) 143 85.00%

ORF Names:v1g101020OrganismNematostel Xenopus tropicalis (Western clawed frog) la vectensis (Starlet sea anemone) ARP51935_P050 Q28J69_XENTR Adaptor‐related protein complex (Silurana tropicalis) 193 85.00%

ORF Names:v1g101020OrganismNematostel la vectensis (Starlet sea anemone) ARP51935_P050 Q5M7C4_XENLA LOC496244 protein Xenopus laevis (African clawed frog) 193 81.00% ARP33248_P050 Q5HZR5_XENLA LOC496325 protein Xenopus laevis (African clawed frog) 470 92.00% ARP33248_P050 Q4KLS2_XENLA MGC115510 protein Xenopus laevis (African clawed frog) 471 92.00% Xenopus tropicalis (Western clawed frog) ARP33248_P050 Q0IIU2_XENTR LOC779621 protein (Fragment) (Silurana tropicalis) 452 92.00% Retinoic acid receptor RXR‐gamma (Nuclear receptor subfamily 2 group B member 3) ARP33248_P050 RXRG_XENLA (Retinoid X receptor gamma) Xenopus laevis (African clawed frog) 470 92.00% Retinoic acid receptor RXR‐alpha (Nuclear receptor subfamily 2 group B member 1) ARP33248_P050 RXRA_XENLA (Retinoid X receptor alpha) Xenopus laevis (African clawed frog) 488 92.00% ARP33248_P050 Q91840_XENLA Retinoid X receptor beta Xenopus laevis (African clawed frog) 412 78.00% ARP33248_P050 Q91613_XENLA XRXR beta Xenopus laevis (African clawed frog) 452 78.00% ARP33248_P050 Q6INZ0_XENLA Rxrb protein Xenopus laevis (African clawed frog) 449 78.00% ARP33248_P050 Q6GPF8_XENLA Rxrb‐A‐prov protein (Fragment) Xenopus laevis (African clawed frog) 451 78.00% ARP33248_P050 Q4FZW9_XENLA Rxrb‐A‐prov protein (Fragment) Xenopus laevis (African clawed frog) 458 78.00% ARP33248_P050 Q2VPP3_XENLA Rxrb‐a protein (Fragment) Xenopus laevis (African clawed frog) 458 78.00% Retinoic acid receptor RXR‐beta (Retinoid X Xenopus tropicalis (Western clawed frog) ARP33248_P050 Q28CI3_XENTR receptor beta) (Silurana tropicalis) 449 78.00% ARP33248_P050 B7FEW3_XENLA Rxrb‐a protein (Fragment) Xenopus laevis (African clawed frog) 445 78.00% Xenopus tropicalis (Western clawed frog) ARP33248_P050 B3DLT9_XENTR Rxrb protein (Silurana tropicalis) 412 78.00%

CTP synthase 1‐B (EC 6.3.4.2) (CTP synthetase ARP46070_T100 PYG1B_XENLA 1‐B) (UTP‐‐ammonia ligase 1‐B) Xenopus laevis (African clawed frog) 591 85.00%

CTP synthase 1‐A (EC 6.3.4.2) (CTP synthetase ARP46070_T100 PYG1A_XENLA 1‐A) (UTP‐‐ammonia ligase 1‐A) Xenopus laevis (African clawed frog) 591 85.00% P100861_P050 Q4PIX9_9PIPI Retinoic acid receptor isoform alpha 2.1 Xenopus sp. (clawed frog) 464 78.00% Retinoic acid receptor alpha (RAR‐alpha) (Nuclear receptor subfamily 1 group B P100861_P050 RARA_XENLA member 1) Xenopus laevis (African clawed frog) 458 78.00% ORF Names:PTD2_10183 EMBL EAR26941.1OrganismPseudoalteromon as tunicata D2 ARP34307_P050 Q7ZXW7_XENLA Cnot4‐prov protein Xenopus laevis (African clawed frog) 712 100.00% ORF Names:PTD2_10183 EMBL EAR26941.1OrganismPseudoalteromon Xenopus tropicalis (Western clawed frog) as tunicata D2 ARP34307_P050 Q5BKS6_XENTR CCR4‐NOT transcription complex, subunit 4 (Silurana tropicalis) 715 100.00% ARP42889_P050 Q66J48_XENLA MGC81923 protein Xenopus laevis (African clawed frog) 519 92.00% Xenopus tropicalis (Western clawed frog) ARP42889_P050 Q28GC6_XENTR Occludin (Ocln protein) (Silurana tropicalis) 518 92.00% Xenopus tropicalis (Western clawed frog) ARP42889_P050 B1WAQ7_XENTR Putative uncharacterized protein (Silurana tropicalis) 228 92.00% LOC398133 protein (Putative uncharacterized ARP42889_P050 B7ZQA0_XENLA protein) Xenopus laevis (African clawed frog) 491 84.00% ARP42889_P050 OCLN_XENLA Occludin Xenopus laevis (African clawed frog) 493 84.00%

DDB1‐ and CUL4‐associated factor 13 (WD Xenopus tropicalis (Western clawed frog) DCAF13 ARP55246_P050 DCA13_XENTR repeat and SOF domain‐containing protein 1) (Silurana tropicalis) 445 84.00%

DDB1‐ and CUL4‐associated factor 13 (WD DCAF13 ARP55246_P050 DCA13_XENLA repeat and SOF domain‐containing protein 1) Xenopus laevis (African clawed frog) 445 84.00% ORF Names:TVAG_426190 EMBL EAY14426.1OrganismTrichomonas Xenopus tropicalis (Western clawed frog) vaginalis ARP46493_P050 A8E5U6_XENTR LOC100127608 protein (Fragment) (Silurana tropicalis) 368 92.00% Xenopus tropicalis (Western clawed frog) tulp4 ARP39410_P050 A9JRM4_XENTR Tulp4 protein (Silurana tropicalis) 1568 100.00% Xenopus tropicalis (Western clawed frog) Plp1 ARP33843_P050 Q4QQQ6_XENTR Putative uncharacterized protein mgc107988 (Silurana tropicalis) 280 92.00% Plp1 ARP33843_P050 MYPRB_XENLA Isoform 2 Xenopus laevis (African clawed frog) 306 92.00% Myelin proteolipid protein B (PLP‐B) Plp1 ARP33843_P050 MYPRB_XENLA (Lipophilin‐B) Xenopus laevis (African clawed frog) 280 92.00% Myelin proteolipid protein A (PLP‐A) Plp1 ARP33843_P050 MYPRA_XENLA (Lipophilin‐A) Xenopus laevis (African clawed frog) 280 92.00% Xenopus tropicalis (Western clawed frog) Dolpp1 ARP49511_P050 Q28F14_XENTR Dolichyl pyrophosphate phosphatase 1 (Silurana tropicalis) 238 100.00% Dolpp1 ARP49511_P050 A6H8J5_XENLA LOC100101332 protein Xenopus laevis (African clawed frog) 238 100.00% Smc1a ARP38780_P050 Q7ZTJ9_XENLA Smc1l1 protein Xenopus laevis (African clawed frog) 1232 92.00% Structural maintenance of chromosomes protein 1A (SMC protein 1A) (SMC‐1A) Smc1a ARP38780_P050 SMC1A_XENLA (xSMC1) Xenopus laevis (African clawed frog) 1232 92.00% Xenopus tropicalis (Western clawed frog) ARP39381_T100 Q6DK89_XENTR DNA methyltransferase 1 associated protein 1 (Silurana tropicalis) 464 100.00% ARP39381_T100 Q641D1_XENLA MGC82015 protein Xenopus laevis (African clawed frog) 464 100.00% Xenopus tropicalis (Western clawed frog) klf4 ARP32760_P050 A0JLZ3_XENTR Klf4 protein (Fragment) (Silurana tropicalis) 418 90.00%

ORF Names:Kpol_1035p22 EMBL EDO17209.1OrganismVanderwaltozym a polyspora (strain ATCC 22028 / DSM Xenopus tropicalis (Western clawed frog) 70294) (Kluyveromyces polysporus) ARP50763_P050 ZN238_XENTR Zinc finger protein 238 (Silurana tropicalis) 521 78.00%

ORF Names:Kpol_1035p22 EMBL EDO17209.1OrganismVanderwaltozym a polyspora (strain ATCC 22028 / DSM 70294) (Kluyveromyces polysporus) ARP50763_P050 Z2383_XENLA Zinc finger protein 238.3 Xenopus laevis (African clawed frog) 519 78.00%

ORF Names:Kpol_1035p22 EMBL EDO17209.1OrganismVanderwaltozym a polyspora (strain ATCC 22028 / DSM 70294) (Kluyveromyces polysporus) ARP50763_P050 Z2382_XENLA Zinc finger protein 238.2 Xenopus laevis (African clawed frog) 472 78.00%

GM20559 ARP32417_P050 Q9DDQ8_XENLA BHLH transcription factor atonal homolog 2 Xenopus laevis (African clawed frog) 336 85.00% Xenopus tropicalis (Western clawed frog) GM20559 ARP32417_P050 Q0VA32_XENTR Neurogenic differentiation 6 (Silurana tropicalis) 337 85.00% GM20559 ARP32417_P050 B7ZSJ0_XENLA Neurod6‐A protein Xenopus laevis (African clawed frog) 337 85.00% GTPase‐activating protein and VPS9 domain‐ GAPVD1 ARP42451_P050 GAPD1_XENLA containing protein 1 Xenopus laevis (African clawed frog) 1452 92.00% TRIM63 ARP43373_P050 Q6INV6_XENLA MGC80214 protein Xenopus laevis (African clawed frog) 360 100.00% TRIM63 ARP43373_P050 A1L2R6_XENLA LOC100036929 protein Xenopus laevis (African clawed frog) 498 92.00% TRIM63 ARP43373_P050 A1L2S7_XENLA LOC100036938 protein Xenopus laevis (African clawed frog) 356 100.00% TRIM63 ARP43373_P050 Q6DE39_XENLA Rnf30‐prov protein Xenopus laevis (African clawed frog) 356 85.00% Xenopus tropicalis (Western clawed frog) TRIM63 ARP43373_P050 Q0D2A2_XENTR Tripartite motif‐containing 63 (Silurana tropicalis) 348 85.00% DGCR2 ARP46575_P050 Q6GM11_XENLA MGC84054 protein Xenopus laevis (African clawed frog) 549 92.00% Xenopus tropicalis (Western clawed frog) DGCR2 ARP46575_P050 Q28DK0_XENTR DiGeorge syndrome critical region gene 2 (Silurana tropicalis) 551 92.00% Xenopus tropicalis (Western clawed frog) CTPS ARP46069_T100 B1H2S0_XENTR LOC100145472 protein (Silurana tropicalis) 578 92.00% CTPS ARP46069_T100 PYG1A_XENLA Isoform 2 Xenopus laevis (African clawed frog) 486 92.00% CTP synthase 2 (EC 6.3.4.2) (CTP synthetase 2) CTPS ARP46069_T100 PYRG2_XENLA (UTP‐‐ammonia ligase 2) Xenopus laevis (African clawed frog) 578 92.00%

CTP synthase 1‐B (EC 6.3.4.2) (CTP synthetase CTPS ARP46069_T100 PYG1B_XENLA 1‐B) (UTP‐‐ammonia ligase 1‐B) Xenopus laevis (African clawed frog) 591 92.00% CTP synthase 1‐A (EC 6.3.4.2) (CTP synthetase CTPS ARP46069_T100 PYG1A_XENLA 1‐A) (UTP‐‐ammonia ligase 1‐A) Xenopus laevis (African clawed frog) 591 92.00% DNA‐binding protein inhibitor ID‐4 (Inhibitor Xenopus tropicalis (Western clawed frog) Id1 ARP32327_P050 ID4_XENTR of DNA binding 4) (Silurana tropicalis) 131 100.00% DNA‐binding protein inhibitor ID‐4 (Inhibitor Id1 ARP32327_P050 ID4_XENLA of DNA binding 4) Xenopus laevis (African clawed frog) 131 100.00% DNA‐binding protein inhibitor ID‐2‐B (Inhibitor Id1 ARP32327_P050 ID2B_XENLA of DNA binding 2‐B) Xenopus laevis (African clawed frog) 135 92.00% DNA‐binding protein inhibitor ID‐2 (Inhibitor Xenopus tropicalis (Western clawed frog) Id1 ARP32327_P050 ID2_XENTR of DNA binding 2) (Silurana tropicalis) 132 84.00% DNA‐binding protein inhibitor ID‐2‐A (Inhibitor Id1 ARP32327_P050 ID2A_XENLA of DNA binding 2‐A) (XId2) Xenopus laevis (African clawed frog) 133 84.00% ORF Names:LMED105_01037 EMBL EDM83144.1OrganismLimnobacter sp. Xenopus tropicalis (Western clawed frog) MED105 P100617_P050 MAF_XENTR Transcription factor Maf (Silurana tropicalis) 352 92.00% ORF Names:LMED105_01037 EMBL EDM83144.1OrganismLimnobacter sp. Xenopus tropicalis (Western clawed frog) MED105 P100617_P050 MAFB_XENTR Transcription factor MafB (Maf‐B) (XMafB) (Silurana tropicalis) 316 78.00% ORF Names:LMED105_01037 EMBL EDM83144.1OrganismLimnobacter sp. MED105 P100617_P050 MAFB_XENLA Transcription factor MafB (Maf‐B) (XMafB) Xenopus laevis (African clawed frog) 313 78.00% ARP35371_P050 Q6AZJ4_XENLA Kctd10‐prov protein Xenopus laevis (African clawed frog) 313 100.00% Potassium channel tetramerisation domain Xenopus tropicalis (Western clawed frog) ARP35371_P050 Q28HW7_XENTR containing 10 (Silurana tropicalis) 267 100.00% ORF Names:OsI_22475 EMBL EAZ00454.1OrganismOryza sativa Xenopus tropicalis (Western clawed frog) subsp. indica (Rice) ARP40448_P050 Q6DET8_XENTR Small nuclear ribonucleoprotein polypeptide F (Silurana tropicalis) 86 100.00% ORF Names:OsI_22475 EMBL EAZ00454.1OrganismOryza sativa Small nuclear ribonucleoprotein F (snRNP‐F) subsp. indica (Rice) ARP40448_P050 RUXF_XENLA (Sm protein F) (Sm‐F) (SmF) Xenopus laevis (African clawed frog) 86 100.00% Morf4l2 ARP32832_T100 Q66J61_XENLA MGC81811 protein Xenopus laevis (African clawed frog) 321 92.00% Xenopus tropicalis (Western clawed frog) Morf4l2 ARP32832_T100 Q5U4Y3_XENTR Mortality factor 4 like 2 (Silurana tropicalis) 323 92.00% Xenopus tropicalis (Western clawed frog) Morf4l2 ARP32832_T100 Q28EZ5_XENTR Mortality factor 4 like 1 (Silurana tropicalis) 323 84.00% Tcf15 ARP38503_T100 Q5SE74_XENLA Paraxis‐like protein Xenopus laevis (African clawed frog) 181 76.00% Tcf15 ARP38503_T100 B7ZR89_XENLA Paraxis‐like protein Xenopus laevis (African clawed frog) 181 76.00% Xenopus tropicalis (Western clawed frog) Tcf15 ARP38503_T100 Q28HQ5_XENTR Transcription factor 15 (Basic helix‐loop‐helix) (Silurana tropicalis) 183 76.00% Xenopus tropicalis (Western clawed frog) Tcf15 ARP38503_T100 B7ZTZ3_XENTR Transcription factor 15 (Basic helix‐loop‐helix) (Silurana tropicalis) 183 76.00% Xenopus tropicalis (Western clawed frog) ARP38379_P050 B1H2C8_XENTR LOC100145389 protein (Silurana tropicalis) 588 92.00% Xenopus tropicalis (Western clawed frog) ARP30163_P050 Q5M7Q2_XENTR Adenylate kinase 7 (Silurana tropicalis) 710 90.00% ARP30163_P050 Q3KQ41_XENLA JC7 protein Xenopus laevis (African clawed frog) 293 81.00% cdk16 AVARP03010_P050 Q5U591_XENLA LOC495331 protein Xenopus laevis (African clawed frog) 522 100.00% Xenopus tropicalis (Western clawed frog) cdk16 AVARP03010_P050 A4IGM5_XENTR LOC100037876 protein (Silurana tropicalis) 469 100.00% Argininosuccinate synthase (EC 6.3.4.5) cdk16 AVARP03010_P050 ASSY_XENLA (Citrulline‐‐aspartate ligase) Xenopus laevis (African clawed frog) 411 76.00% ORF Names:GSPATT00032819001 EMBL CAK62967.1OrganismParamecium tetraurelia ARP30228_T100 Q1WM12_XENLA Telomeric repeat binding factor 2 Xenopus laevis (African clawed frog) 468 100.00% ORF Names:GSPATT00032819001 EMBL CAK62967.1OrganismParamecium Xenopus tropicalis (Western clawed frog) tetraurelia ARP30228_T100 B8QB44_XENTR Telomeric repeat binding factor 2 (Silurana tropicalis) 471 100.00% ORF Names:GSPATT00032819001 EMBL CAK62967.1OrganismParamecium tetraurelia ARP30228_T100 B8QB41_XENLA Telomeric repeat binding factor 2 Xenopus laevis (African clawed frog) 468 100.00% ORF Names:GSPATT00032819001 EMBL CAK62967.1OrganismParamecium tetraurelia ARP30228_T100 Q71E47_XENLA Telomeric repeat binding factor 1 Xenopus laevis (African clawed frog) 420 90.00% ORF Names:GSPATT00032819001 EMBL CAK62967.1OrganismParamecium tetraurelia ARP30228_T100 Q2LK75_XENLA Telomeric repeat binding factor 1 Xenopus laevis (African clawed frog) 419 90.00% ORF Names:GSPATT00032819001 EMBL CAK62967.1OrganismParamecium tetraurelia ARP30228_T100 B8QB40_XENLA Telomeric repeat binding factor 1 Xenopus laevis (African clawed frog) 420 90.00% ORF Names:GSPATT00032819001 EMBL CAK62967.1OrganismParamecium tetraurelia ARP30228_T100 B7ZR57_XENLA Telomeric repeat binding factor 1 Xenopus laevis (African clawed frog) 420 90.00% ORF Names:GSPATT00032819001 EMBL CAK62967.1OrganismParamecium Xenopus tropicalis (Western clawed frog) tetraurelia ARP30228_T100 B8QB43_XENTR Telomeric repeat binding factor 1 (Silurana tropicalis) 421 90.00% DNA‐binding protein inhibitor ID‐4 (Inhibitor Xenopus tropicalis (Western clawed frog) ARP38058_T100 ID4_XENTR of DNA binding 4) (Silurana tropicalis) 131 85.00% DNA‐binding protein inhibitor ID‐4 (Inhibitor ARP38058_T100 ID4_XENLA of DNA binding 4) Xenopus laevis (African clawed frog) 131 85.00% lrrfip1a ARP38506_P050 LRRF2_XENLA Isoform 2 Xenopus laevis (African clawed frog) 405 90.00%

Leucine‐rich repeat flightless‐interacting Xenopus tropicalis (Western clawed frog) lrrfip1a ARP38506_P050 LRRF2_XENTR protein 2 (LRR FLII‐interacting protein 2) (Silurana tropicalis) 404 90.00% Leucine‐rich repeat flightless‐interacting protein 2 (LRR FLII‐interacting protein 2) lrrfip1a ARP38506_P050 LRRF2_XENLA (xLRRFIP2) Xenopus laevis (African clawed frog) 729 90.00% Xenopus tropicalis (Western clawed frog) ARP38607_P050 MAF_XENTR Transcription factor Maf (Silurana tropicalis) 352 100.00% Xenopus tropicalis (Western clawed frog) ARP38607_P050 MAFA_XENTR Transcription factor MafA (Silurana tropicalis) 289 78.00% TAF10 ARP31425_P050 Q0IH90_XENLA Taf10b protein Xenopus laevis (African clawed frog) 196 100.00% gdi1 AVARP13086_T100 Q642Q8_XENLA MGC84311 protein Xenopus laevis (African clawed frog) 447 92.00% Tcfap2a ARP38284_T100 Q63ZP3_XENLA Tcfap2a protein Xenopus laevis (African clawed frog) 433 84.00%

Transcription factor AP‐2 alpha (Activating Xenopus tropicalis (Western clawed frog) Tcfap2a ARP38284_T100 Q28EF6_XENTR enhancer binding protein 2 alpha) (Silurana tropicalis) 436 84.00% Tcfap2a ARP38284_T100 Q6NTJ1_XENLA MGC68493 protein Xenopus laevis (African clawed frog) 442 78.00% ZMIZ1 ARP39413_P050 A2BD96_XENLA Rps2e protein Xenopus laevis (African clawed frog) 358 100.00% Xenopus tropicalis (Western clawed frog) rnf8 ARP40071_T100 B4F701_XENTR Putative uncharacterized protein (Silurana tropicalis) 342 91.00% E3 ubiquitin‐protein ligase RNF8‐B (EC 6.3.2.‐) rnf8 ARP40071_T100 RNF8B_XENLA (RING finger protein 8‐B) Xenopus laevis (African clawed frog) 532 91.00% E3 ubiquitin‐protein ligase RNF8‐A (EC 6.3.2.‐) rnf8 ARP40071_T100 RNF8A_XENLA (RING finger protein 8‐A) Xenopus laevis (African clawed frog) 540 91.00% Xenopus tropicalis (Western clawed frog) ARP38773_T100 Q6P2Z8_XENTR Tumor susceptibility gene 101 (Silurana tropicalis) 395 100.00% ARP38773_T100 Q6NUD5_XENLA MGC81040 protein Xenopus laevis (African clawed frog) 394 100.00% Xenopus tropicalis (Western clawed frog) CDK5 AVARP03025_P050 Q0VFL9_XENTR Cyclin‐dependent kinase 5 (Silurana tropicalis) 292 100.00% Cyclin‐dependent kinase 5 (EC 2.7.11.22) (Cell division protein kinase 5) (Neuronal cyclin‐ CDK5 AVARP03025_P050 CDK5_XENLA dependent kinase 5) Xenopus laevis (African clawed frog) 292 100.00% ORF Names:OsI_20144 EMBL EAY98233.1OrganismOryza sativa Xenopus tropicalis (Western clawed frog) subsp. indica (Rice) ARP38401_P050 A4IHH6_XENTR C77604 protein (Silurana tropicalis) 144 100.00% ORF Names:OsI_20144 EMBL EAY98233.1OrganismOryza sativa subsp. indica (Rice) ARP38401_P050 BUD31_XENLA Protein BUD31 homolog (Protein G10) Xenopus laevis (African clawed frog) 144 92.00% ORF Names:GSTENG00028242001 EMBL CAG07547.1OrganismTetraodon nigroviridis (Green puffer) ARP38941_T100 Q8JJ42_XENLA Mitotic phosphoprotein 39 Xenopus laevis (African clawed frog) 412 78.00%

ORF Names:GSTENG00028242001 EMBL CAG07547.1OrganismTetraodon nigroviridis (Green puffer) ARP38941_T100 Q7ZXS6_XENLA Tardbp‐prov protein Xenopus laevis (African clawed frog) 245 78.00%

ORF Names:GSTENG00028242001 EMBL CAG07547.1OrganismTetraodon Xenopus tropicalis (Western clawed frog) nigroviridis (Green puffer) ARP38941_T100 TADBP_XENTR TAR DNA‐binding protein 43 (TDP‐43) (Silurana tropicalis) 409 78.00%

TAF7 RNA polymerase II, TATA box binding Xenopus tropicalis (Western clawed frog) Taf7 P100967_T100 Q6DII5_XENTR protein (TBP)‐associated factor, 55kDa (Silurana tropicalis) 349 92.00% Taf7 P100967_T100 Q6DEC0_XENLA MGC78979 protein Xenopus laevis (African clawed frog) 347 92.00% Taf7 P100967_T100 Q3KQE2_XENLA MGC78979 protein Xenopus laevis (African clawed frog) 346 92.00% TAF7 RNA polymerase II, TATA box binding protein (TBP)‐associated factor, 55kDa Xenopus tropicalis (Western clawed frog) Taf7 P100967_T100 Q28G03_XENTR (Fragment) (Silurana tropicalis) 296 92.00% CH73‐301C19.1 ARP44701_T100 Q6NTL2_XENLA MGC83215 protein Xenopus laevis (African clawed frog) 432 100.00% Mannosyl (Alpha‐1,6‐)‐glycoprotein beta‐1,2‐ Xenopus tropicalis (Western clawed frog) CH73‐301C19.1 ARP44701_T100 Q6DIJ6_XENTR N‐acetylglucosaminyltransferase (Silurana tropicalis) 432 100.00% Mannosyl (Alpha‐1,6‐)‐glycoprotein beta‐1,2‐ Xenopus tropicalis (Western clawed frog) CH73‐301C19.1 ARP44701_T100 Q28HY1_XENTR N‐acetylglucosaminyltransferase (Silurana tropicalis) 432 100.00% Alpha‐1,6‐mannosyl‐glycoprotein 2‐beta‐N‐ CH73‐301C19.1 ARP44701_T100 Q7ZZX7_XENLA acetylglucosaminyltransferase Xenopus laevis (African clawed frog) 432 92.00% CH73‐301C19.1 ARP44701_T100 Q6GLT2_XENLA MGC84280 protein Xenopus laevis (African clawed frog) 432 92.00% CH73‐301C19.1 ARP44701_T100 Q566K5_XENLA MGC98819 protein Xenopus laevis (African clawed frog) 421 92.00% CH73‐301C19.1 ARP44701_T100 Q6DFF0_XENLA MGC83705 protein Xenopus laevis (African clawed frog) 419 85.00% Ordered Locus Names:NT01CX_1009OrganismClostridi ATP‐binding cassette, sub‐family G (WHITE), Xenopus tropicalis (Western clawed frog) um novyi (strain NT) ARP43649_T100 Q28BS4_XENTR member 2 (Silurana tropicalis) 661 92.00% Ordered Locus Names:NT01CX_1009OrganismClostridi um novyi (strain NT) ARP43649_T100 A1L2M4_XENLA LOC100036892 protein Xenopus laevis (African clawed frog) 661 92.00%

ORF Names:zgc:153917 ZFIN ZDB‐GENE‐ 070112‐1242OrganismDanio rerio Xenopus tropicalis (Western clawed frog) (Zebrafish) (Brachydanio rerio) ARP52414_P050 A8WGF3_XENTR LOC100127680 protein (Silurana tropicalis) 837 92.00% Ptprf ARP46732_P050 Q91556_XENLA Protein tyrosine phosphatase alpha Xenopus laevis (African clawed frog) 822 100.00% Ptprf ARP46732_P050 Q52L02_XENLA Ptpra protein Xenopus laevis (African clawed frog) 819 100.00% Ptprf ARP46732_P050 Q52KD2_XENLA Ptpa‐A‐prov protein Xenopus laevis (African clawed frog) 822 100.00% Xenopus tropicalis (Western clawed frog) Ptprf ARP46732_P050 B2GU66_XENTR LOC100158513 protein (Silurana tropicalis) 819 100.00%

Ptprf ARP46732_P050 Q9IAJ1_XENLA Receptor protein tyrosine phosphatase delta Xenopus laevis (African clawed frog) 1896 85.00%

Ptprf ARP46732_P050 Q9IAJ0_XENLA Receptor protein tyrosine phosphatase LAR Xenopus laevis (African clawed frog) 1788 85.00% Receptor protein tyrosine phosphatase CRYP‐ Ptprf ARP46732_P050 Q9IAI8_XENLA alpha (Fragment) Xenopus laevis (African clawed frog) 615 85.00% Ptprf ARP46732_P050 B7ZS86_XENLA XPTP‐D protein Xenopus laevis (African clawed frog) 1897 85.00% folD ARP46038_T100 Q6IP36_XENLA MGC78982 protein Xenopus laevis (African clawed frog) 335 92.00% folD ARP46038_T100 Q6DDQ6_XENLA Mthfd2‐prov protein Xenopus laevis (African clawed frog) 335 92.00% folD ARP46038_T100 Q2VPP2_XENLA MGC78982 protein Xenopus laevis (African clawed frog) 335 92.00% Xenopus tropicalis (Western clawed frog) folD ARP46038_T100 B3DL74_XENTR LOC100170462 protein (Silurana tropicalis) 335 92.00% Xenopus tropicalis (Western clawed frog) ARP56208_P050 RS21_XENTR 40S ribosomal protein S21 (Silurana tropicalis) 83 100.00% ARP56208_P050 RS21_XENLA 40S ribosomal protein S21 Xenopus laevis (African clawed frog) 83 100.00% Xenopus tropicalis (Western clawed frog) mafa ARP33682_T100 MAFB_XENTR Transcription factor MafB (Maf‐B) (XMafB) (Silurana tropicalis) 316 92.00% mafa ARP33682_T100 MAFB_XENLA Transcription factor MafB (Maf‐B) (XMafB) Xenopus laevis (African clawed frog) 313 92.00% Xenopus tropicalis (Western clawed frog) mafa ARP33682_T100 MAF_XENTR Transcription factor Maf (Silurana tropicalis) 352 84.00% Xenopus tropicalis (Western clawed frog) mafa ARP33682_T100 MAFA_XENTR Transcription factor MafA (Silurana tropicalis) 289 84.00% mafa ARP33682_T100 Q9PUA5_XENLA BZIP transcription factor L‐Maf Xenopus laevis (African clawed frog) 267 76.00% Xenopus tropicalis (Western clawed frog) mafa ARP33682_T100 Q4U1T9_XENTR Leucine zipper transcription factor (Silurana tropicalis) 267 76.00% mafa ARP33682_T100 B7ZRB4_XENLA BZIP transcription factor L‐Maf Xenopus laevis (African clawed frog) 267 76.00% Xenopus tropicalis (Western clawed frog) mafa ARP33682_T100 A4IHY9_XENTR Leucine zipper transcription factor (Silurana tropicalis) 267 76.00% Ordered Locus Names:Arth_3218OrganismArthrobacte Kelch repeat and BTB domain‐containing Xenopus tropicalis (Western clawed frog) r sp. (strain FB24) ARP39889_P050 KBTB5_XENTR protein 5 (Silurana tropicalis) 614 92.00% Ordered Locus Names:Arth_3218OrganismArthrobacte Kelch repeat and BTB domain‐containing r sp. (strain FB24) ARP39889_P050 KBTB5_XENLA protein 5 Xenopus laevis (African clawed frog) 614 92.00% HIF‐1a AVARP20009_P050 Q6PI54_XENLA Hif1a‐prov protein Xenopus laevis (African clawed frog) 802 86.00%

Hypoxia‐inducible factor 1, alpha subunit Xenopus tropicalis (Western clawed frog) HIF‐1a AVARP20009_P050 Q5U4Q8_XENTR (Basic helix‐loop‐helix transcription factor) (Silurana tropicalis) 328 92.00% HIF‐1a AVARP20009_P050 A5X382_XENLA Hypoxia inducible factor 1 alpha Xenopus laevis (African clawed frog) 800 85.00% HIF‐1a AVARP20009_P050 A0JMU1_XENLA HIF‐1a protein Xenopus laevis (African clawed frog) 800 85.00% Hypoxia‐inducible factor 1‐alpha (HIF‐1‐alpha) HIF‐1a AVARP20009_P050 HIF1A_XENLA (HIF1‐alpha) Xenopus laevis (African clawed frog) 805 85.00% HIF‐1a AVARP20009_P050 Q6GQ12_XENLA MGC80468 protein Xenopus laevis (African clawed frog) 859 78.00% HIF‐1a AVARP20009_P050 Q6GP97_XENLA MGC80589 protein Xenopus laevis (African clawed frog) 862 78.00% Xenopus tropicalis (Western clawed frog) HIF‐1a AVARP20009_P050 Q6GL61_XENTR Endothelial PAS domain protein 1 (Silurana tropicalis) 862 78.00% ECT2 ARP52381_P050 Q5XGV4_XENLA Ect2 protein Xenopus laevis (African clawed frog) 986 92.00% Xenopus tropicalis (Western clawed frog) ECT2 ARP52381_P050 A9JTS6_XENTR LOC100127840 protein (Silurana tropicalis) 878 92.00% ECT2 ARP52381_P050 Q6RWT0_XENLA Epithelial cell transforming 2 Xenopus laevis (African clawed frog) 910 85.00% ECT2 ARP52381_P050 Q6GN25_XENLA ECT2 protein Xenopus laevis (African clawed frog) 985 85.00% Xenopus tropicalis (Western clawed frog) gclm ARP54624_P050 Q28HQ7_XENTR Glutamate‐cysteine ligase, modifier subunit (Silurana tropicalis) 274 85.00% Xenopus tropicalis (Western clawed frog) gclm ARP54624_P050 Q28CS0_XENTR Glutamate‐cysteine ligase, modifier subunit (Silurana tropicalis) 274 85.00% gclm ARP54624_P050 Q7ZXV1_XENLA Gclm‐prov protein Xenopus laevis (African clawed frog) 274 85.00% PHACTR1 ARP53447_P050 Q32NG1_XENLA MGC131329 protein Xenopus laevis (African clawed frog) 415 100.00% Xenopus tropicalis (Western clawed frog) PHACTR1 ARP53447_P050 B1H2M8_XENTR Phactr3 protein (Silurana tropicalis) 560 100.00% Xenopus tropicalis (Western clawed frog) PHACTR1 ARP53447_P050 A4IIQ5_XENTR Phactr3 protein (Silurana tropicalis) 577 100.00% Xenopus tropicalis (Western clawed frog) PHACTR1 ARP53447_P050 B5DE18_XENTR Putative uncharacterized protein (Silurana tropicalis) 587 76.00% PHACTR1 ARP53447_P050 PHAR1_XENLA Phosphatase and actin regulator 1 Xenopus laevis (African clawed frog) 586 76.00% FUBP3 ARP35703_T100 Q8AX84_XENLA FUSE binding protein‐like protein Xenopus laevis (African clawed frog) 610 85.00% FUBP3 ARP35703_T100 Q7ZXS1_XENLA Fubp1 protein Xenopus laevis (African clawed frog) 653 85.00% Far upstream element (FUSE) binding protein Xenopus tropicalis (Western clawed frog) FUBP3 ARP35703_T100 Q6P3Q5_XENTR 1 (Silurana tropicalis) 653 85.00% MGC78835 protein (Putative uncharacterized FUBP3 ARP35703_T100 Q6IRB9_XENLA protein MGC78835) Xenopus laevis (African clawed frog) 653 85.00% Xenopus tropicalis (Western clawed frog) FUBP3 ARP35703_T100 Q28BR2_XENTR OTTXETP00000007035 (Silurana tropicalis) 653 85.00% Xenopus tropicalis (Western clawed frog) FUBP3 ARP35703_T100 A4IH51_XENTR Fubp3 protein (Silurana tropicalis) 546 83.00% FUBP3 ARP35703_T100 Q6PAA0_XENLA MGC68532 protein Xenopus laevis (African clawed frog) 546 75.00% mfap4 ARP41500_P050 A2VDA6_XENLA LOC100037202 protein Xenopus laevis (African clawed frog) 254 92.00% Xenopus tropicalis (Western clawed frog) PDS5B ARP58313_P050 A9UMH0_XENTR LOC100135353 protein (Silurana tropicalis) 1449 92.00% Sister chromatid cohesion protein PDS5 homolog B‐B (Androgen‐induced proliferation PDS5B ARP58313_P050 PD5BB_XENLA inhibitor B) Xenopus laevis (African clawed frog) 1464 92.00% Sister chromatid cohesion protein PDS5 homolog B‐A (Androgen‐induced proliferation PDS5B ARP58313_P050 PD5BA_XENLA inhibitor A) Xenopus laevis (African clawed frog) 1448 92.00% ARCN1 ARP54594_P050 Q7T0U9_XENLA Arcn1 protein Xenopus laevis (African clawed frog) 513 100.00% Xenopus tropicalis (Western clawed frog) ARCN1 ARP54594_P050 Q28E96_XENTR 1 (Silurana tropicalis) 513 100.00%

ORF Names:CH211‐127C19.1‐001 EMBL CAP09391.1, CH211‐285O8.1‐001 EMBL CAK04930.1OrganismDanio rerio Xenopus tropicalis (Western clawed frog) (Zebrafish) (Brachydanio rerio) ARP38701_T100 B1H161_XENTR Meox2 protein (Silurana tropicalis) 300 85.00%

ORF Names:CH211‐127C19.1‐001 EMBL CAP09391.1, CH211‐285O8.1‐001 EMBL CAK04930.1OrganismDanio rerio (Zebrafish) (Brachydanio rerio) ARP38701_T100 Q7ZXL2_XENLA Meox2‐prov protein Xenopus laevis (African clawed frog) 298 78.00%

ORF Names:CH211‐127C19.1‐001 EMBL CAP09391.1, CH211‐285O8.1‐001 EMBL CAK04930.1OrganismDanio rerio (Zebrafish) (Brachydanio rerio) ARP38701_T100 MEOX2_XENLA Homeobox protein MOX‐2 Xenopus laevis (African clawed frog) 298 78.00% ORF Names:PICST_84962 EMBL ABN67559.2OrganismPichia stipitis Xenopus tropicalis (Western clawed frog) (Yeast) ARP40434_P050 A4IHP7_XENTR LOC100124876 protein (Silurana tropicalis) 299 83.00% PSMD4 ARP32342_T100 Q7ZTP3_XENLA Xrpn10c protein (Fragment) Xenopus laevis (African clawed frog) 387 100.00% Proteasome (Prosome, macropain) 26S Xenopus tropicalis (Western clawed frog) PSMD4 ARP32342_T100 Q6NVQ2_XENTR subunit, non‐ATPase, 4 (Silurana tropicalis) 377 100.00% PSMD4 ARP32342_T100 Q588Y8_XENLA 26S proteasome subunit Xenopus laevis (African clawed frog) 355 100.00% 26S proteasome subunit (Proteasome subunit PSMD4 ARP32342_T100 Q588Y7_XENLA xrpn10) Xenopus laevis (African clawed frog) 376 100.00% PSMD4 ARP32342_T100 Q4V845_XENLA Xrpn10c protein Xenopus laevis (African clawed frog) 376 100.00% Xenopus tropicalis (Western clawed frog) PSMD4 ARP32342_T100 A9UM91_XENTR LOC100135276 protein (Fragment) (Silurana tropicalis) 133 78.00% brrn1 ARP46227_P050 B2L406_XENBO Barren (Fragment) Xenopus borealis (Kenyan clawed frog) 31 85.00% brrn1 ARP46227_P050 Q7T0P8_XENLA complex subunit 2 Xenopus laevis (African clawed frog) 689 78.00% brrn1 ARP46227_P050 Q6NUE8_XENLA Condensin complex subunit 2 Xenopus laevis (African clawed frog) 698 78.00% Xenopus tropicalis (Western clawed frog) brrn1 ARP46227_P050 Q66KA2_XENTR Condensin complex subunit 2 (Silurana tropicalis) 703 78.00% Xenopus tropicalis (Western clawed frog) brrn1 ARP46227_P050 Q28DW7_XENTR Condensin complex subunit 2 (Silurana tropicalis) 703 78.00% Condensin complex subunit 2 (Barren homolog) (Chromosome assembly protein xCAP‐H) (Chromosome‐associated protein H) brrn1 ARP46227_P050 CND2_XENLA (Non‐SMC condensin I complex subunit H) Xenopus laevis (African clawed frog) 699 78.00% Xenopus tropicalis (Western clawed frog) PHF16 ARP39631_P050 A1A5F9_XENTR Phf17 protein (Silurana tropicalis) 782 92.00% PHF16 ARP39631_P050 JADE1_XENLA Protein Jade‐1 (PHD finger protein 17) Xenopus laevis (African clawed frog) 827 92.00% Xenopus tropicalis (Western clawed frog) PHF16 ARP39631_P050 JADE3_XENTR Protein Jade‐3 (PHD finger protein 16) (Silurana tropicalis) 817 78.00% PHF16 ARP39631_P050 Q4QQY4_XENLA LOC733278 protein (Fragment) Xenopus laevis (African clawed frog) 544 76.00% ythdf3 ARP55529_P050 Q66J89_XENLA MGC81605 protein Xenopus laevis (African clawed frog) 572 100.00% Xenopus tropicalis (Western clawed frog) ythdf3 ARP55529_P050 B1H2Z7_XENTR LOC100145519 protein (Silurana tropicalis) 572 100.00% LOC100135141 protein (Putative Xenopus tropicalis (Western clawed frog) ARP56147_P050 A9JSD7_XENTR uncharacterized protein LOC100135141) (Silurana tropicalis) 194 100.00% 40S ribosomal protein S7 (40S ribosomal ARP56147_P050 RS7_XENLA protein S8) Xenopus laevis (African clawed frog) 194 100.00%

Peptidase M20 domain‐containing protein 2 Xenopus tropicalis (Western clawed frog) Pm20d2 ARP51811_P050 P20D2_XENTR (Aminoacylase‐1‐like protein 2) (Silurana tropicalis) 443 100.00% Runx1t1 ARP33996_T100 Q5IJ72_XENLA MTG8 Xenopus laevis (African clawed frog) 582 92.00% Rod1 ARP40421_P050 Q7ZXB4_XENLA Ptbp1 protein Xenopus laevis (African clawed frog) 547 100.00% Xenopus tropicalis (Western clawed frog) Rod1 ARP40421_P050 Q5XGH0_XENTR Polypyrimidine tract binding protein 1 (Silurana tropicalis) 554 100.00% HnRNP I‐related RNA transport protein Rod1 ARP40421_P050 Q9PTS5_XENLA VgRBP60 Xenopus laevis (African clawed frog) 552 92.00% Rod1 ARP40421_P050 Q4QR55_XENLA VgRBP60 protein Xenopus laevis (African clawed frog) 472 92.00% Xenopus tropicalis (Western clawed frog) Rod1 ARP40421_P050 B1H3K0_XENTR LOC100145652 protein (Silurana tropicalis) 519 92.00% Xenopus tropicalis (Western clawed frog) Rod1 ARP40421_P050 Q0P4U3_XENTR Polypyrimidine tract binding protein 2 (Silurana tropicalis) 531 90.00% ORF Names:SS1G_12821 EMBL EDN97965.1OrganismSclerotinia sclerotiorum (strain ATCC 18683 / 1980 / Ss‐1) (White mold) (Whetzelinia sclerotiorum) ARP57742_P050 Q8AVD2_XENLA Psma3‐prov protein Xenopus laevis (African clawed frog) 255 92.00% ORF Names:SS1G_12821 EMBL EDN97965.1OrganismSclerotinia sclerotiorum (strain ATCC 18683 / 1980 Proteasome (Prosome macropain) subunit / Ss‐1) (White mold) (Whetzelinia alpha type 3 (Proteasome (Prosome, Xenopus tropicalis (Western clawed frog) sclerotiorum) ARP57742_P050 Q5PPP6_XENTR macropain) subunit, alpha type, 3) (Silurana tropicalis) 255 92.00% ORF Names:SS1G_12821 EMBL EDN97965.1OrganismSclerotinia sclerotiorum (strain ATCC 18683 / 1980 / Ss‐1) (White mold) (Whetzelinia Proteasome subunit alpha type 3 alpha sclerotiorum) ARP57742_P050 B2L4K8_XENBO (Fragment) Xenopus borealis (Kenyan clawed frog) 38 92.00% ORF Names:SS1G_12821 EMBL EDN97965.1OrganismSclerotinia sclerotiorum (strain ATCC 18683 / 1980 / Ss‐1) (White mold) (Whetzelinia sclerotiorum) ARP57742_P050 Q6PE96_XENLA MGC68557 protein Xenopus laevis (African clawed frog) 255 84.00% ORF Names:SS1G_12821 EMBL EDN97965.1OrganismSclerotinia sclerotiorum (strain ATCC 18683 / 1980 / Ss‐1) (White mold) (Whetzelinia Proteasome subunit alpha type 3 beta sclerotiorum) ARP57742_P050 B2L4K9_XENBO (Fragment) Xenopus borealis (Kenyan clawed frog) 50 85.00% ORF Names:SS1G_12821 EMBL EDN97965.1OrganismSclerotinia sclerotiorum (strain ATCC 18683 / 1980 / Ss‐1) (White mold) (Whetzelinia Xenopus tropicalis (Western clawed frog) sclerotiorum) ARP57742_P050 A9UMF5_XENTR LOC100135338 protein (Silurana tropicalis) 138 76.00% Xenopus tropicalis (Western clawed frog) mett10d ARP47674_P050 B3DL09_XENTR LOC100170444 protein (Silurana tropicalis) 549 100.00% Putative methyltransferase METT10D (EC 2.1.1.‐) (Methyltransferase 10 domain‐ mett10d ARP47674_P050 MET10_XENLA containing protein) Xenopus laevis (African clawed frog) 547 100.00% ARP40875_T100 Q6IRQ2_XENLA MGC82224 protein Xenopus laevis (African clawed frog) 614 90.00% Xenopus tropicalis (Western clawed frog) ARP40875_T100 Q28C94_XENTR Nuclear RNA export factor 1 (Silurana tropicalis) 620 90.00% Xenopus tropicalis (Western clawed frog) lgals8 ARP53656_P050 B4F6X4_XENTR Putative uncharacterized protein (Silurana tropicalis) 315 85.00% lgals8 ARP53656_P050 Q7ZTB5_XENLA Galectin family xgalectin‐VIIIa Xenopus laevis (African clawed frog) 315 85.00% lgals8 ARP53656_P050 A1L2W2_XENLA Xgalectin‐VIIIa protein Xenopus laevis (African clawed frog) 315 85.00% Putative uncharacterized protein Xenopus tropicalis (Western clawed frog) Echdc2 ARP48829_P050 B7ZU88_XENTR LOC100135206 (Silurana tropicalis) 294 85.00% Xenopus tropicalis (Western clawed frog) Echdc2 ARP48829_P050 A9ULH7_XENTR LOC100135206 protein (Silurana tropicalis) 294 85.00% Transcriptional adapter 1 (Transcriptional TADA1 ARP52480_P050 TADA1_XENLA adapter 1‐like protein) Xenopus laevis (African clawed frog) 331 78.00% Transcriptional adapter 1 (Transcriptional Xenopus tropicalis (Western clawed frog) TADA1 ARP52480_P050 TADA1_XENTR adapter 1‐like protein) (Silurana tropicalis) 331 78.00% Xenopus tropicalis (Western clawed frog) cited2 ARP38735_P050 CITE2_XENTR Cbp/p300‐interacting transactivator 2 (Silurana tropicalis) 225 85.00% cited2 ARP38735_P050 CITE2_XENLA Cbp/p300‐interacting transactivator 2 Xenopus laevis (African clawed frog) 225 85.00% Xenopus tropicalis (Western clawed frog) ESRRG ARP45602_P050 A4IIT9_XENTR Esrrg protein (Silurana tropicalis) 435 100.00% ORF Names:PANDA_002310 EMBL EFB20290.1OrganismAiluropoda melanoleuca (Giant panda) ARP40778_P050 Q6DKE8_XENLA MGC81834 protein Xenopus laevis (African clawed frog) 584 78.00%

Bifunctional arginine demethylase and lysyl‐ hydroxylase JMJD6‐B (EC 1.14.11.‐) (Histone arginine demethylase JMJD6‐B) (JmjC domain‐ containing protein 6‐B) (Jumonji domain‐ containing protein 6‐B) (Lysyl‐hydroxylase JMJD6‐B) (Peptide‐lysine 5‐dioxygenase JMJD6‐B) (Phosphatidylserine receptor‐B) JMJD6 ARP39180_P050 JMD6B_XENLA (Protein PTDSR‐B) Xenopus laevis (African clawed frog) 403 92.00%

Bifunctional arginine demethylase and lysyl‐ hydroxylase JMJD6‐A (EC 1.14.11.‐) (Histone arginine demethylase JMJD6‐A) (JmjC domain‐ containing protein 6‐A) (Jumonji domain‐ containing protein 6‐A) (Lysyl‐hydroxylase JMJD6‐A) (Peptide‐lysine 5‐dioxygenase JMJD6‐A) (Phosphatidylserine receptor‐A) JMJD6 ARP39180_P050 JMD6A_XENLA (Protein PTDSR‐A) Xenopus laevis (African clawed frog) 403 92.00% imp alpha 4 ARP54674_P050 Q70PC6_XENLA Importin alpha 4 protein Xenopus laevis (African clawed frog) 521 100.00% imp alpha 4 ARP54674_P050 Q6IRB7_XENLA MGC78841 protein Xenopus laevis (African clawed frog) 521 100.00% Xenopus tropicalis (Western clawed frog) imp alpha 4 ARP54674_P050 Q28EX2_XENTR Karyopherin (Importin) alpha 3 (Silurana tropicalis) 521 100.00% imp alpha 4 ARP54674_P050 B7ZQX4_XENLA Importin alpha 4 protein Xenopus laevis (African clawed frog) 521 100.00% imp alpha 4 ARP54674_P050 Q6NS18_XENLA MGC78839 protein Xenopus laevis (African clawed frog) 520 76.00% ARP46600_T100 Q6GR19_XENLA MGC81350 protein Xenopus laevis (African clawed frog) 242 78.00% ARP46600_T100 Q5U4V4_XENLA LOC495425 protein Xenopus laevis (African clawed frog) 128 78.00% Xenopus tropicalis (Western clawed frog) ARP46600_T100 Q566M7_XENTR Myeloid leukemia factor 2 (Silurana tropicalis) 242 78.00%

Malate dehydrogenase, cytoplasmic (EC Xenopus tropicalis (Western clawed frog) ARP48284_T100 MDHC_XENTR 1.1.1.37) (Cytosolic malate dehydrogenase) (Silurana tropicalis) 334 84.00%

Malate dehydrogenase, cytoplasmic (EC ARP48284_T100 MDHC_XENLA 1.1.1.37) (Cytosolic malate dehydrogenase) Xenopus laevis (African clawed frog) 334 84.00%

Homeobox protein engrailed‐1‐B (En‐1B) CH211‐190D13.1 ARP38029_P050 HME1B_XENLA (Homeobox protein en‐1‐B) (Fragment) Xenopus laevis (African clawed frog) 171 85.00% CH211‐190D13.1 ARP38029_P050 Q3KQ43_XENLA MGC130999 protein Xenopus laevis (African clawed frog) 229 80.00% ARP41699_T100 Q6PA20_XENLA MGC68714 protein Xenopus laevis (African clawed frog) 531 100.00% Xenopus tropicalis (Western clawed frog) ARP41699_T100 Q28HE2_XENTR Pyruvate kinase, muscle (Silurana tropicalis) 527 92.00% Xenopus tropicalis (Western clawed frog) ARP41699_T100 Q0D2C2_XENTR Putative uncharacterized protein MGC146985 (Silurana tropicalis) 527 92.00% Pyruvate kinase muscle isozyme (EC 2.7.1.40) (Cytosolic thyroid hormone‐binding protein) ARP41699_T100 KPYK_XENLA (CTHBP) Xenopus laevis (African clawed frog) 527 92.00% ARP41699_T100 Q7ZY25_XENLA Pkm2‐prov protein Xenopus laevis (African clawed frog) 527 85.00% ARP41699_T100 A1L3K2_XENLA LOC100037030 protein Xenopus laevis (African clawed frog) 531 85.00% Xenopus tropicalis (Western clawed frog) ARP41699_T100 A9UMA9_XENTR LOC100135293 protein (Silurana tropicalis) 180 85.00% Argininosuccinate synthase (EC 6.3.4.5) ARP41366_T100 ASSY_XENLA (Citrulline‐‐aspartate ligase) Xenopus laevis (African clawed frog) 411 92.00% Argininosuccinate synthase (EC 6.3.4.5) Xenopus tropicalis (Western clawed frog) ARP41366_T100 ASSY_XENTR (Citrulline‐‐aspartate ligase) (Silurana tropicalis) 412 85.00% ORF Names:PANDA_001818 EMBL EFB28529.1OrganismAiluropoda Xenopus tropicalis (Western clawed frog) melanoleuca (Giant panda) ARP41597_T100 Q0VFA8_XENTR Small muscle protein, X‐linked (Silurana tropicalis) 91 84.00% ORF Names:PANDA_013353 EMBL EFB26071.1OrganismAiluropoda melanoleuca (Giant panda) ARP42935_T100 TM178_XENLA Transmembrane protein 178 Xenopus laevis (African clawed frog) 304 85.00% Xenopus tropicalis (Western clawed frog) chrna4 ARP34965_P050 A9JRM3_XENTR LOC100135106 protein (Silurana tropicalis) 734 85.00% ORF Names:PANDA_019110 EMBL EFB21055.1OrganismAiluropoda melanoleuca (Giant panda) ARP44576_T100 Q6IP08_XENLA MGC79069 protein Xenopus laevis (African clawed frog) 364 85.00% ORF Names:zgc:173617 EMBL AAI52598.1 ZFIN ZDB‐GENE‐071004‐ 87OrganismDanio rerio (Zebrafish) Xenopus tropicalis (Western clawed frog) (Brachydanio rerio) ARP50957_P050 B1H2H6_XENTR Putative uncharacterized protein (Silurana tropicalis) 320 81.00% ORF Names:zgc:173617 EMBL AAI52598.1 ZFIN ZDB‐GENE‐071004‐ 87OrganismDanio rerio (Zebrafish) Xenopus tropicalis (Western clawed frog) (Brachydanio rerio) ARP50957_P050 B3DLP1_XENTR Putative uncharacterized protein (Silurana tropicalis) 293 90.00% ORF Names:zgc:173617 EMBL AAI52598.1 ZFIN ZDB‐GENE‐071004‐ 87OrganismDanio rerio (Zebrafish) Xenopus tropicalis (Western clawed frog) (Brachydanio rerio) ARP50957_P050 B2GU02_XENTR Putative uncharacterized protein (Silurana tropicalis) 432 90.00% ORF Names:zgc:173617 EMBL AAI52598.1 ZFIN ZDB‐GENE‐071004‐ 87OrganismDanio rerio (Zebrafish) Xenopus tropicalis (Western clawed frog) (Brachydanio rerio) ARP50957_P050 B1H2A8_XENTR LOC100145373 protein (Silurana tropicalis) 321 90.00% ORF Names:ACLA_026800 EMBL EAW07958.1OrganismAspergillus clavatus ARP40465_P050 Q9PW90_XENLA CRM1/XPO1 protein Xenopus laevis (African clawed frog) 1071 92.00% ORF Names:ACLA_026800 EMBL EAW07958.1OrganismAspergillus clavatus ARP40465_P050 Q6NS03_XENLA Xpo1 protein Xenopus laevis (African clawed frog) 1071 92.00% ORF Names:CC1G_11074 EMBL EAU89378.2OrganismCoprinopsis cinerea (strain Okayama‐7 / 130 / FGSC Ubiquitin‐conjugating enzyme E2D 2 (UBC4/5 9003) (Inky cap fungus) homolog, yeast) (Ubiquitin‐conjugating Xenopus tropicalis (Western clawed frog) (Hormographiella aspergillata) ARP43009_P050 Q28EY6_XENTR enzyme E2D 3 (UBC4/5 homolog)) (Silurana tropicalis) 147 92.00% ORF Names:CC1G_11074 EMBL EAU89378.2OrganismCoprinopsis Ubiquitin‐conjugating enzyme E2 D2 (EC cinerea (strain Okayama‐7 / 130 / FGSC 6.3.2.19) (Ubiquitin carrier protein 4) (xUBC4) 9003) (Inky cap fungus) (Ubiquitin carrier protein D2) (Ubiquitin‐ (Hormographiella aspergillata) ARP43009_P050 UB2D2_XENLA protein ligase D2) Xenopus laevis (African clawed frog) 147 92.00% ORF Names:CC1G_11074 EMBL EAU89378.2OrganismCoprinopsis cinerea (strain Okayama‐7 / 130 / FGSC 9003) (Inky cap fungus) (Hormographiella aspergillata) ARP43009_P050 Q6DFK8_XENLA LOC495381 protein (Ube2d2‐prov protein) Xenopus laevis (African clawed frog) 147 84.00% ORF Names:CC1G_11074 EMBL EAU89378.2OrganismCoprinopsis cinerea (strain Okayama‐7 / 130 / FGSC 9003) (Inky cap fungus) Ubiquitin‐conjugating enzyme E2D 1 (UBC4/5 Xenopus tropicalis (Western clawed frog) (Hormographiella aspergillata) ARP43009_P050 A0JM78_XENTR homolog) (Silurana tropicalis) 147 84.00% ORF Names:CC1G_11074 EMBL EAU89378.2OrganismCoprinopsis cinerea (strain Okayama‐7 / 130 / FGSC Ubiquitin‐conjugating enzyme E2 D4 (EC 9003) (Inky cap fungus) 6.3.2.19) (Ubiquitin carrier protein D4) (Hormographiella aspergillata) ARP43009_P050 UB2D4_XENLA (Ubiquitin‐protein ligase D4) Xenopus laevis (African clawed frog) 147 84.00% Xenopus tropicalis (Western clawed frog) p60 ARP45826_P050 A8E5V8_XENTR LOC100127620 protein (Fragment) (Silurana tropicalis) 473 100.00% p60 ARP45826_P050 Q07CZ6_XENLA Chromatin assembly factor‐1 p60 subunit Xenopus laevis (African clawed frog) 569 100.00% p60 ARP45826_P050 A0PCL5_XENLA Chromatin assembly factor 1 Xenopus laevis (African clawed frog) 569 100.00% Xenopus tropicalis (Western clawed frog) Chic1 ARP44893_T100 B1H2D5_XENTR LOC100145395 protein (Silurana tropicalis) 169 78.00% Chic1 ARP44893_T100 Q6DFH4_XENLA Chic2‐prov protein Xenopus laevis (African clawed frog) 166 78.00% LOC100135210 protein (Putative Xenopus tropicalis (Western clawed frog) Chic1 ARP44893_T100 A9ULJ0_XENTR uncharacterized protein LOC100135210) (Silurana tropicalis) 166 78.00% ARP46856_P050 Q6DFH4_XENLA Chic2‐prov protein Xenopus laevis (African clawed frog) 166 92.00% Xenopus tropicalis (Western clawed frog) ARP46856_P050 B1H2D5_XENTR LOC100145395 protein (Silurana tropicalis) 169 92.00% LOC100135210 protein (Putative Xenopus tropicalis (Western clawed frog) ARP46856_P050 A9ULJ0_XENTR uncharacterized protein LOC100135210) (Silurana tropicalis) 166 92.00% CNN2 ARP48161_P050 Q6PAB2_XENLA MGC68737 protein Xenopus laevis (African clawed frog) 297 78.00% CNN2 ARP48161_P050 Q7ZX19_XENLA Calponin 2 copy A (Cnn2‐prov protein) Xenopus laevis (African clawed frog) 294 78.00% Xenopus tropicalis (Western clawed frog) CNN2 ARP48161_P050 Q6NVQ5_XENTR Calponin 2 (Silurana tropicalis) 295 78.00% CNN2 ARP48161_P050 Q6GNN7_XENLA MGC80982 protein Xenopus laevis (African clawed frog) 295 78.00% CNN2 ARP48161_P050 O93547_XENLA Calponin H3 Xenopus laevis (African clawed frog) 295 78.00% CNN2 ARP48161_P050 A9CDP5_XENLA Calponin 2 copy B Xenopus laevis (African clawed frog) 295 78.00% Xenopus tropicalis (Western clawed frog) CNN2 ARP48161_P050 Q5FVW2_XENTR MGC108411 protein (Silurana tropicalis) 297 78.00% ARP48038_P050 Q642N8_XENLA MGC86380 protein Xenopus laevis (African clawed frog) 329 92.00% ARP48038_P050 Q4V7M0_XENLA Strap protein Xenopus laevis (African clawed frog) 273 92.00% Xenopus tropicalis (Western clawed frog) ARP48038_P050 B1H3F3_XENTR LOC100145616 protein (Silurana tropicalis) 327 92.00% ORF Names:SIAM614_15250 EMBL EAV44167.1OrganismLabrenzia aggregata IAM 12614 ARP48312_T100 Q8AVD7_XENLA Ndufv1 protein Xenopus laevis (African clawed frog) 471 100.00% ORF Names:SIAM614_15250 EMBL NADH dehydrogenase (Ubiquinone) EAV44167.1OrganismLabrenzia flavoprotein 1 (NADH dehydrogenase Xenopus tropicalis (Western clawed frog) aggregata IAM 12614 ARP48312_T100 Q5HZV1_XENTR (Ubiquinone) flavoprotein 1, 51kDa) (Silurana tropicalis) 468 100.00% Transcriptional adaptor 2 (ADA2 homolog)‐ like (Transcriptional adaptor 2 (ADA2 Xenopus tropicalis (Western clawed frog) Tada2a ARP38045_P050 Q28IK5_XENTR homolog, yeast)‐like) (Silurana tropicalis) 445 91.00%

ORF Names:AgaP_AGAP012660 EMBL EAU77798.1OrganismAnopheles gambiae str. PEST ARP44683_T100 B2GTY2_XENLA LOC100158451 protein Xenopus laevis (African clawed frog) 557 100.00% Xenopus tropicalis (Western clawed frog) LDHA ARP53602_P050 Q6PBE7_XENTR Lactate dehydrogenase B (Silurana tropicalis) 334 100.00% Lactate dehydrogenase A1 (EC 1.1.1.27) LDHA ARP53602_P050 Q9W7M7_XENLA (Ldhab protein) Xenopus laevis (African clawed frog) 332 85.00% L‐lactate dehydrogenase M chain (EC 1.1.1.27) (Lactate dehydrogenase A2) (EC 1.1.1.27) LDHA ARP53602_P050 Q9W5Z7_XENLA (Ldha‐prov protein) Xenopus laevis (African clawed frog) 332 85.00% Xenopus tropicalis (Western clawed frog) LDHA ARP53602_P050 Q6P7L5_XENTR Lactate dehydrogenase A (Silurana tropicalis) 332 85.00% LDHA ARP53602_P050 Q7SYU9_XENLA Ldhba protein Xenopus laevis (African clawed frog) 334 85.00% L‐lactate dehydrogenase C chain (LDH‐C) (EC LDHA ARP53602_P050 LDHC_XENLA 1.1.1.27) Xenopus laevis (African clawed frog) 334 85.00% L‐lactate dehydrogenase B chain (LDH‐B) (EC LDHA ARP53602_P050 LDHB_XENLA 1.1.1.27) Xenopus laevis (African clawed frog) 334 85.00% L‐lactate dehydrogenase A chain (LDH‐A) (EC LDHA ARP53602_P050 LDHA_XENLA 1.1.1.27) Xenopus laevis (African clawed frog) 334 85.00% Xenopus tropicalis (Western clawed frog) ARP52988_P050 Q0V9Y7_XENTR Putative uncharacterized protein MGC145710 (Silurana tropicalis) 400 85.00% ARP52988_P050 A9ULX4_XENLA LOC100137639 protein Xenopus laevis (African clawed frog) 416 85.00% Xenopus tropicalis (Western clawed frog) ARP54776_P050 Q6P7L5_XENTR Lactate dehydrogenase A (Silurana tropicalis) 332 78.00% ORF Names:OsI_06114 EMBL EAY84744.1OrganismOryza sativa subsp. indica (Rice) ARP56464_P050 Q5PQ24_XENLA LOC496005 protein Xenopus laevis (African clawed frog) 205 85.00% ORF Names:OsI_06114 EMBL EAY84744.1OrganismOryza sativa subsp. indica (Rice) ARP56464_P050 Q5M999_XENLA Putative uncharacterized protein Xenopus laevis (African clawed frog) 205 85.00% ORF Names:OsI_06114 EMBL EAY84744.1OrganismOryza sativa Proteasome (Prosome macropain) subunit Xenopus tropicalis (Western clawed frog) subsp. indica (Rice) ARP56464_P050 Q28HP8_XENTR beta type 3 (Silurana tropicalis) 194 85.00% ORF Names:OsI_06114 EMBL EAY84744.1OrganismOryza sativa Proteasome (Prosome, macropain) subunit, Xenopus tropicalis (Western clawed frog) subsp. indica (Rice) ARP56464_P050 A9ULB6_XENTR beta type 3 (Silurana tropicalis) 205 85.00%

ORF Names:GP2143_15901 EMBL EAW32754.1Organismmarine gamma proteobacterium HTCC2143 ARP54452_P050 Q3KQ72_XENLA MGC130905 protein Xenopus laevis (African clawed frog) 351 85.00%

ORF Names:GP2143_15901 EMBL EAW32754.1Organismmarine gamma proteobacterium HTCC2143 ARP54452_P050 Q5XH11_XENLA LOC495094 protein Xenopus laevis (African clawed frog) 256 78.00%

ORF Names:GP2143_15901 EMBL EAW32754.1Organismmarine gamma Xenopus tropicalis (Western clawed frog) proteobacterium HTCC2143 ARP54452_P050 Q6GL80_XENTR Hydroxymethylbilane synthase (Silurana tropicalis) 351 81.00% Xenopus tropicalis (Western clawed frog) Klhl32 ARP52449_P050 A4IJ04_XENTR Klhl32 protein (Silurana tropicalis) 548 100.00% Klhl32 ARP52449_P050 Q08AX1_XENLA LOC100158396 protein Xenopus laevis (African clawed frog) 620 92.00% Ordered Locus Names:MSMEG_2478OrganismMycoba cterium smegmatis (strain ATCC 700084 / mc(2)155) ARP41681_T100 Q7SYS7_XENLA Fah‐prov protein Xenopus laevis (African clawed frog) 420 92.00% Ordered Locus Names:MSMEG_2478OrganismMycoba cterium smegmatis (strain ATCC Xenopus tropicalis (Western clawed frog) 700084 / mc(2)155) ARP41681_T100 A9UMK8_XENTR LOC100135385 protein (Silurana tropicalis) 420 92.00%

ORF Names:v1g177644OrganismNematostel la vectensis (Starlet sea anemone) ARP46620_P050 Q498F4_XENLA LOC734217 protein (Fragment) Xenopus laevis (African clawed frog) 521 100.00%

ORF Names:v1g177644OrganismNematostel la vectensis (Starlet sea anemone) ARP46620_P050 Q2VPL8_XENLA MGC131189 protein Xenopus laevis (African clawed frog) 523 100.00% Grainyhead‐like protein 2 homolog Xenopus tropicalis (Western clawed frog) ARP39635_P050 GRHL2_XENTR (Transcription factor CP2‐like 3) (Silurana tropicalis) 619 100.00% ARP39635_P050 B7ZQZ4_XENLA Grhl1 protein Xenopus laevis (African clawed frog) 621 92.00% Grainyhead‐like protein 1 homolog ARP39635_P050 GRHL1_XENLA (Transcription factor CP2‐like 2) Xenopus laevis (African clawed frog) 609 92.00% ARP39635_P050 Q640H0_XENLA LOC494716 protein (Fragment) Xenopus laevis (African clawed frog) 602 83.00% Grainyhead‐like protein 3 homolog Xenopus tropicalis (Western clawed frog) ARP39635_P050 GRHL3_XENTR (Transcription factor CP2‐like 4) (Silurana tropicalis) 594 83.00% Grainyhead‐like protein 3 homolog ARP39635_P050 GRHL3_XENLA (Transcription factor CP2‐like 4) Xenopus laevis (African clawed frog) 595 83.00%

ORF Names:CH211‐249G22.3‐001 EMBL CAM56463.1OrganismDanio rerio (Zebrafish) (Brachydanio rerio) ARP55781_P050 TSN33_XENLA Tetraspanin‐33 (Tspan‐33) Xenopus laevis (African clawed frog) 268 92.00% Putative uncharacterized protein enox1 ARP40886_P050 B7ZR01_XENLA LOC100127295 Xenopus laevis (African clawed frog) 575 92.00% Putative uncharacterized protein enox1 ARP40886_P050 B7ZQZ9_XENLA LOC100127295 Xenopus laevis (African clawed frog) 575 92.00% enox1 ARP40886_P050 A9JS36_XENLA LOC100127295 protein Xenopus laevis (African clawed frog) 575 92.00% RPB9 ARP38758_P050 Q5EAU6_XENLA MGC85139 protein Xenopus laevis (African clawed frog) 125 100.00% ARP54275_P050 Q7T0Y5_XENLA Acads protein Xenopus laevis (African clawed frog) 409 92.00% Acyl‐Coenzyme A dehydrogenase, C‐2 to C‐3 Xenopus tropicalis (Western clawed frog) ARP54275_P050 Q6P324_XENTR short chain (Silurana tropicalis) 409 92.00% COPB1 ARP52371_P050 Q6GNR5_XENLA MGC80934 protein Xenopus laevis (African clawed frog) 960 92.00% COPB1 ARP52371_P050 Q498K6_XENLA MGC114704 protein Xenopus laevis (African clawed frog) 953 92.00% Xenopus tropicalis (Western clawed frog) COPB1 ARP52371_P050 B5DEA8_XENTR Putative uncharacterized protein (Silurana tropicalis) 953 92.00% psmd8 ARP48216_P050 Q6NU38_XENLA LOC414721 protein (Fragment) Xenopus laevis (African clawed frog) 269 78.00% psmd8 ARP48216_P050 Q6NTJ8_XENLA LOC414691 protein (Fragment) Xenopus laevis (African clawed frog) 267 78.00% psmd8 ARP48216_P050 Q05AY5_XENLA LOC414691 protein Xenopus laevis (African clawed frog) 257 78.00% psmd8 ARP48216_P050 A3KMH9_XENLA Putative uncharacterized protein (Fragment) Xenopus laevis (African clawed frog) 273 78.00% psmd8 ARP48216_P050 A2RV94_XENLA LOC414721 protein Xenopus laevis (African clawed frog) 271 78.00%

ORF Retinoic acid receptor RXR‐alpha (Nuclear Names:v1g242271OrganismNematostel receptor subfamily 2 group B member 1) la vectensis (Starlet sea anemone) ARP45610_P050 RXRA_XENLA (Retinoid X receptor alpha) Xenopus laevis (African clawed frog) 488 92.00%

ORF Names:v1g242271OrganismNematostel la vectensis (Starlet sea anemone) ARP45610_P050 Q5HZR5_XENLA LOC496325 protein Xenopus laevis (African clawed frog) 470 85.00%

ORF Names:v1g242271OrganismNematostel la vectensis (Starlet sea anemone) ARP45610_P050 Q4KLS2_XENLA MGC115510 protein Xenopus laevis (African clawed frog) 471 85.00%

ORF Names:v1g242271OrganismNematostel Xenopus tropicalis (Western clawed frog) la vectensis (Starlet sea anemone) ARP45610_P050 Q0IIU2_XENTR LOC779621 protein (Fragment) (Silurana tropicalis) 452 85.00%

ORF Retinoic acid receptor RXR‐gamma (Nuclear Names:v1g242271OrganismNematostel receptor subfamily 2 group B member 3) la vectensis (Starlet sea anemone) ARP45610_P050 RXRG_XENLA (Retinoid X receptor gamma) Xenopus laevis (African clawed frog) 470 85.00%

ORF Names:v1g242271OrganismNematostel la vectensis (Starlet sea anemone) ARP45610_P050 Q91840_XENLA Retinoid X receptor beta Xenopus laevis (African clawed frog) 412 78.00%

ORF Names:v1g242271OrganismNematostel la vectensis (Starlet sea anemone) ARP45610_P050 Q91613_XENLA XRXR beta Xenopus laevis (African clawed frog) 452 78.00%

ORF Names:v1g242271OrganismNematostel la vectensis (Starlet sea anemone) ARP45610_P050 Q6INZ0_XENLA Rxrb protein Xenopus laevis (African clawed frog) 449 78.00%

ORF Names:v1g242271OrganismNematostel la vectensis (Starlet sea anemone) ARP45610_P050 Q6GPF8_XENLA Rxrb‐A‐prov protein (Fragment) Xenopus laevis (African clawed frog) 451 78.00%

ORF Names:v1g242271OrganismNematostel la vectensis (Starlet sea anemone) ARP45610_P050 Q4FZW9_XENLA Rxrb‐A‐prov protein (Fragment) Xenopus laevis (African clawed frog) 458 78.00% ORF Names:v1g242271OrganismNematostel la vectensis (Starlet sea anemone) ARP45610_P050 Q2VPP3_XENLA Rxrb‐a protein (Fragment) Xenopus laevis (African clawed frog) 458 78.00%

ORF Names:v1g242271OrganismNematostel Retinoic acid receptor RXR‐beta (Retinoid X Xenopus tropicalis (Western clawed frog) la vectensis (Starlet sea anemone) ARP45610_P050 Q28CI3_XENTR receptor beta) (Silurana tropicalis) 449 78.00%

ORF Names:v1g242271OrganismNematostel la vectensis (Starlet sea anemone) ARP45610_P050 B7FEW3_XENLA Rxrb‐a protein (Fragment) Xenopus laevis (African clawed frog) 445 78.00%

ORF Names:v1g242271OrganismNematostel Xenopus tropicalis (Western clawed frog) la vectensis (Starlet sea anemone) ARP45610_P050 B3DLT9_XENTR Rxrb protein (Silurana tropicalis) 412 78.00%

XRCC6 ARP34117_T100 Q9W626_XENLA Ku70 autoantigen homologue (Fragment) Xenopus laevis (African clawed frog) 611 76.00% Xenopus tropicalis (Western clawed frog) XRCC6 ARP34117_T100 Q6DJB1_XENTR Thyroid autoantigen 70kDa (Ku antigen) (Silurana tropicalis) 611 76.00% XRCC6 ARP34117_T100 Q6AZR6_XENLA LOC398357 protein Xenopus laevis (African clawed frog) 611 76.00% dtx1 ARP43285_P050 Q801Q2_XENLA Dtx2 protein Xenopus laevis (African clawed frog) 544 78.00% dtx1 ARP43285_P050 Q76IH9_XENLA Deltex 1 Xenopus laevis (African clawed frog) 622 85.00% Xenopus tropicalis (Western clawed frog) dtx1 ARP43285_P050 Q6NVS4_XENTR Deltex homolog 2 (Drosophila) (Silurana tropicalis) 592 78.00% dtx1 ARP43285_P050 B7ZRU0_XENLA XDTX1 protein Xenopus laevis (African clawed frog) 623 85.00% Xenopus tropicalis (Western clawed frog) dtx1 ARP43285_P050 A8WGI2_XENTR Dtx1 protein (Fragment) (Silurana tropicalis) 491 85.00% dtx1 ARP43285_P050 DTX1_XENLA Protein deltex‐1 (xDtx1) Xenopus laevis (African clawed frog) 623 85.00% Xenopus tropicalis (Western clawed frog) afg3l2 ARP46780_P050 A0JM92_XENTR Putative uncharacterized protein MGC147390 (Silurana tropicalis) 807 100.00% afg3l2 ARP46780_P050 Q6GNE6_XENLA LOC443667 protein (Fragment) Xenopus laevis (African clawed frog) 769 100.00%

AFG3 ATPase family gene 3‐like 2 Xenopus tropicalis (Western clawed frog) afg3l2 ARP46780_P050 Q28CE0_XENTR (AFG3(ATPase family gene 3)‐like 1 (Yeast)) (Silurana tropicalis) 778 100.00% afg3l2 ARP46780_P050 Q6IR62_XENLA LOC432063 protein (Fragment) Xenopus laevis (African clawed frog) 788 92.00%

ORF Names:IscW_ISCW017004 EMBL EEC03564.1OrganismIxodes scapularis (Black‐legged tick) (Deer tick) ARP41958_P050 Q6GLV7_XENLA MGC84179 protein Xenopus laevis (African clawed frog) 294 92.00% ORF Names:IscW_ISCW017004 EMBL EEC03564.1OrganismIxodes scapularis Novel calcineurin‐like phosphoesterase Xenopus tropicalis (Western clawed frog) (Black‐legged tick) (Deer tick) ARP41958_P050 Q28GP2_XENTR (Ortholog of human c11orf8) (Silurana tropicalis) 294 92.00% ARP43192_P050 Q6GMD5_XENLA Nedd4 protein Xenopus laevis (African clawed frog) 971 100.00% Neural cell expressed, developmentally down‐ Xenopus tropicalis (Western clawed frog) ARP43192_P050 Q6DIR6_XENTR regulated 4‐like (Silurana tropicalis) 970 100.00% ARP43192_P050 O42573_XENLA Nedd4 protein Xenopus laevis (African clawed frog) 971 100.00% PIGK ARP40587_P050 Q5U4J9_XENLA LOC495482 protein (Fragment) Xenopus laevis (African clawed frog) 373 92.00% PIGK ARP40587_P050 Q3B8L4_XENLA LOC495482 protein (Fragment) Xenopus laevis (African clawed frog) 388 92.00% Xenopus tropicalis (Western clawed frog) PIGK ARP40587_P050 Q05AQ6_XENTR Putative uncharacterized protein MGC147622 (Silurana tropicalis) 391 92.00% RUNX1 ARP38074_P050 RUNX1_XENLA Isoform 2 Xenopus laevis (African clawed frog) 476 92.00%

Runt‐related transcription factor 1 (Acute myeloid leukemia 1 protein) (XAML) (Core‐ RUNX1 ARP38074_P050 RUNX1_XENLA binding factor subunit alpha‐2) (CBF‐alpha‐2) Xenopus laevis (African clawed frog) 462 92.00% PA2G4 ARP47602_T100 Q7ZXR5_XENLA Pa2g4 protein (Fragment) Xenopus laevis (African clawed frog) 395 100.00% PA2G4 ARP47602_T100 Q6GNV0_XENLA MGC80858 protein Xenopus laevis (African clawed frog) 390 100.00% Xenopus tropicalis (Western clawed frog) PA2G4 ARP47602_T100 Q66KL8_XENTR MGC79578 protein (Silurana tropicalis) 390 100.00% PA2G4 ARP47602_T100 Q5U5C4_XENLA Pa2g4 protein Xenopus laevis (African clawed frog) 390 100.00% Xenopus tropicalis (Western clawed frog) PA2G4 ARP47602_T100 Q28FX5_XENTR Proliferation‐associated 2G4 (Fragment) (Silurana tropicalis) 367 100.00% Xenopus tropicalis (Western clawed frog) rbl1 P100682_P050 B4F726_XENTR Putative uncharacterized protein (Silurana tropicalis) 1048 85.00%

ORF Names:MGP2080_00215 EMBL EAW40852.1Organismmarine gamma Xenopus tropicalis (Western clawed frog) proteobacterium HTCC2080 ARP58473_P050 Q6P8G5_XENTR Glutathione peroxidase 3 (Silurana tropicalis) 157 76.00% ARP55433_P050 Q7ZXE8_XENLA Ehd4 protein Xenopus laevis (African clawed frog) 537 85.00% Xenopus tropicalis (Western clawed frog) runx2a ARP38453_P050 B5BNX8_XENTR Runx2 (Silurana tropicalis) 468 100.00% Runt‐related transcription factor 2 type I runx2a ARP38453_P050 A1YIX9_XENLA (Fragment) Xenopus laevis (African clawed frog) 455 100.00% runx2a ARP38453_P050 A1YIX8_XENLA Runt‐related transcription factor 2 type II Xenopus laevis (African clawed frog) 469 100.00% runx2a ARP38453_P050 D5KZX4_XENLA Runt‐related transcription factor 3 Xenopus laevis (African clawed frog) 393 92.00% PDLIM1 ARP55067_P050 PDLI3_XENLA PDZ and LIM domain protein 3 Xenopus laevis (African clawed frog) 358 92.00% Xenopus tropicalis (Western clawed frog) PDLIM1 ARP55067_P050 Q6DJ22_XENTR PDZ and LIM domain 3 (Silurana tropicalis) 251 85.00% Xenopus tropicalis (Western clawed frog) TCF12 ARP38267_T100 A4IIL6_XENTR Tcf3 protein (Silurana tropicalis) 655 78.00% TCF12 ARP38267_T100 TFE2_XENLA Isoform E47 Xenopus laevis (African clawed frog) 651 78.00% Transcription factor E2‐alpha (Transcription factor 3) (TCF‐3) (Transcription factor TCF12 ARP38267_T100 TFE2_XENLA XE12/XE47) Xenopus laevis (African clawed frog) 658 78.00% METTL3 ARP34590_T100 Q6NUC3_XENLA MGC81069 protein Xenopus laevis (African clawed frog) 573 100.00% Xenopus tropicalis (Western clawed frog) METTL3 ARP34590_T100 Q28H22_XENTR Methyltransferase like 3 (Silurana tropicalis) 573 100.00% ARP38763_T100 Q9DG50_XENLA Class IV POU‐homeodomain protein Xenopus laevis (African clawed frog) 343 100.00% Class IV POU‐homeodomain protein ARP38763_T100 Q9DG32_XENLA (Fragment) Xenopus laevis (African clawed frog) 358 100.00% Xenopus tropicalis (Western clawed frog) ARP38763_T100 A4IGJ4_XENTR Pou4f1.2 protein (Silurana tropicalis) 340 100.00% ARP38763_T100 Q91835_XENLA POU domain protein (Fragment) Xenopus laevis (African clawed frog) 57 92.00% ARP40716_T100 Q7ZX79_XENLA p54nrb protein Xenopus laevis (African clawed frog) 464 76.00% ARP40716_T100 Q2V0J2_XENLA 54 kD nuclear RNA‐binding protein Xenopus laevis (African clawed frog) 463 76.00% Survival of motor neuron‐related‐splicing factor 30 (Survival motor neuron domain‐ Xenopus tropicalis (Western clawed frog) ARP40612_P050 SPF30_XENTR containing protein 1) (Silurana tropicalis) 238 92.00% Probable glutamyl‐tRNA synthetase, mitochondrial (EC 6.1.1.17) (Glutamate‐‐tRNA Xenopus tropicalis (Western clawed frog) gltX ARP51888_P050 SYEM_XENTR ligase) (GluRS) (Silurana tropicalis) 516 85.00% LOC100127849 ARP51940_P050 A9ULZ7_XENLA LOC100137658 protein (Fragment) Xenopus laevis (African clawed frog) 283 76.00% Xenopus tropicalis (Western clawed frog) LOC100127849 ARP51940_P050 A9JTU0_XENTR LOC100127849 protein (Fragment) (Silurana tropicalis) 297 76.00%

ORF Names:v1g161387OrganismNematostel Xenopus tropicalis (Western clawed frog) la vectensis (Starlet sea anemone) ARP55243_P050 B1WAP4_XENTR LOC100145689 protein (Silurana tropicalis) 712 100.00% Xenopus tropicalis (Western clawed frog) GSC ARP38599_T100 Q4LDP9_XENTR Goosecoid (Goosecoid homeobox) (Silurana tropicalis) 243 84.00% Xenopus tropicalis (Western clawed frog) GSC ARP38599_T100 Q28IZ8_XENTR Goosecoid (Silurana tropicalis) 292 84.00% Xenopus tropicalis (Western clawed frog) GSC ARP38599_T100 Q0IIX2_XENTR LOC100135186 protein (Silurana tropicalis) 243 84.00% Xenopus tropicalis (Western clawed frog) GSC ARP38599_T100 A9JSP2_XENTR Gsc protein (Silurana tropicalis) 226 84.00% GSC ARP38599_T100 GSCB_XENLA Homeobox protein goosecoid isoform B Xenopus laevis (African clawed frog) 243 84.00% GSC ARP38599_T100 GSCA_XENLA Homeobox protein goosecoid isoform A Xenopus laevis (African clawed frog) 243 84.00% bap ARP38751_P050 Q801Q9_XENLA Nkx3‐1 protein (Nkx3‐1‐prov protein) Xenopus laevis (African clawed frog) 213 78.00% Homeobox protein koza (Homeodomain bap ARP38751_P050 KOZA_XENLA transcription factor koza) Xenopus laevis (African clawed frog) 213 78.00% bap ARP38751_P050 ZAX_XENLA Homeobox protein zampogna (Xzax) Xenopus laevis (African clawed frog) 224 100.00% Guanine nucleotide binding protein (G protein), alpha activating activity polypeptide Xenopus tropicalis (Western clawed frog) ga‐1 ARP55425_P050 Q28EM9_XENTR O (Silurana tropicalis) 354 100.00% Guanine nucleotide‐binding protein G(O) ga‐1 ARP55425_P050 O93564_XENLA alpha subunit 1 Xenopus laevis (African clawed frog) 354 100.00% Alpha 01 subunit of heterotrimeric GTP‐ ga‐1 ARP55425_P050 O13011_XENLA binding protein (Gnao1‐A protein) Xenopus laevis (African clawed frog) 354 100.00% ga‐1 ARP55425_P050 B7ZR93_XENLA G protein alpha subunit Xenopus laevis (African clawed frog) 354 100.00% ga‐1 ARP55425_P050 B7ZR87_XENLA G protein alpha subunit Xenopus laevis (African clawed frog) 354 100.00% Guanine nucleotide‐binding protein G(o) ga‐1 ARP55425_P050 GNAO_XENLA subunit alpha Xenopus laevis (African clawed frog) 354 100.00% ga‐1 ARP55425_P050 Q5U4X0_XENLA Gnai3 protein Xenopus laevis (African clawed frog) 355 92.00% Guanine nucleotide‐binding protein Gi alpha ga‐1 ARP55425_P050 O93565_XENLA subunit (Fragment) Xenopus laevis (African clawed frog) 350 92.00% Xenopus tropicalis (Western clawed frog) ga‐1 ARP55425_P050 A4IGY7_XENTR LOC100038283 protein (Silurana tropicalis) 354 92.00% Guanine nucleotide‐binding protein G(i) subunit alpha‐1 (Adenylate cyclase‐inhibiting ga‐1 ARP55425_P050 GNAI1_XENLA G alpha protein) Xenopus laevis (African clawed frog) 354 92.00% ga‐1 ARP55425_P050 Q7ZXT7_XENLA MGC53612 protein Xenopus laevis (African clawed frog) 354 92.00% Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide Xenopus tropicalis (Western clawed frog) ga‐1 ARP55425_P050 Q5I080_XENTR 3 (Silurana tropicalis) 354 92.00%

Guanine nucleotide‐binding protein G(k) ga‐1 ARP55425_P050 GNAI3_XENLA subunit alpha (G(i) alpha‐3) (Fragment) Xenopus laevis (African clawed frog) 345 92.00% Xenopus tropicalis (Western clawed frog) ga‐1 ARP55425_P050 Q6P3M7_XENTR Putative uncharacterized protein MGC76300 (Silurana tropicalis) 355 92.00% ORF Names:LinJ20.1470 EMBL CAM67525.1OrganismLeishmania MGC69435 protein (Signal sequence receptor, Xenopus tropicalis (Western clawed frog) infantum ARP45429_T100 Q6DK88_XENTR beta (Translocon‐associated protein beta)) (Silurana tropicalis) 183 92.00% ORF Names:LinJ20.1470 EMBL CAM67525.1OrganismLeishmania MGC53499 protein (Signal sequence receptor infantum ARP45429_T100 Q98SP1_XENLA beta subunit) Xenopus laevis (African clawed frog) 183 85.00% Xenopus tropicalis (Western clawed frog) ARP31478_P050 B1H2D1_XENTR LOC100145392 protein (Silurana tropicalis) 270 92.00% ARP31478_P050 Q91768_XENLA Xcad 1 protein (Fragment) Xenopus laevis (African clawed frog) 157 84.00% ARP31478_P050 Q32NJ4_XENLA Putative uncharacterized protein Xenopus laevis (African clawed frog) 254 84.00% ARP31478_P050 Q2T9K7_XENLA MGC130987 protein Xenopus laevis (African clawed frog) 256 84.00% ARP31478_P050 Q91542_XENLA Xcad‐3 protein Xenopus laevis (African clawed frog) 274 83.00%

Cad1 (Caudal type homeo box transcription Xenopus tropicalis (Western clawed frog) ARP31478_P050 Q90X90_XENTR factor 2) (Caudal type homeobox 2) (Silurana tropicalis) 252 83.00% Xenopus tropicalis (Western clawed frog) ARP31478_P050 Q90X88_XENTR Cad3 (Caudal type homeobox 4) (Silurana tropicalis) 260 83.00% ARP31478_P050 Q7T0X3_XENLA Cdx4 protein Xenopus laevis (African clawed frog) 260 83.00% ARP31478_P050 Q32NU3_XENLA Cdx4 protein Xenopus laevis (African clawed frog) 260 83.00% Caudal type homeo box transcription factor 1 Xenopus tropicalis (Western clawed frog) ARP31478_P050 Q07G97_XENTR (Fragment) (Silurana tropicalis) 202 83.00% ARP31478_P050 Q03922_XENLA Xcad 2 protein (Fragment) Xenopus laevis (African clawed frog) 141 83.00% Xenopus tropicalis (Western clawed frog) ARP31478_P050 B7ZUR8_XENTR Caudal type homeobox 1 (Silurana tropicalis) 262 83.00% ARP31478_P050 A6H8J8_XENLA XCAD2 protein Xenopus laevis (African clawed frog) 263 83.00% Xenopus tropicalis (Western clawed frog) ARP31478_P050 CDX1_XENTR Homeobox protein ‐1 (Silurana tropicalis) 262 83.00% ARP31478_P050 CDX1_XENLA Homeobox protein CDX‐1 (xCAD2) Xenopus laevis (African clawed frog) 263 83.00%

ORF Names:27085OrganismMonosiga Asparagine‐linked glycosylation protein 11 brevicollis (Choanoflagellate) ARP44463_P050 ALG11_XENLA homolog (EC 2.4.‐.‐) Xenopus laevis (African clawed frog) 486 92.00%

ORF Names:27085OrganismMonosiga Asparagine‐linked glycosylation protein 11 Xenopus tropicalis (Western clawed frog) brevicollis (Choanoflagellate) ARP44463_P050 ALG11_XENTR homolog (EC 2.4.‐.‐) (Silurana tropicalis) 487 85.00% yap1 ARP50530_P050 Q32NJ6_XENLA Putative uncharacterized protein Xenopus laevis (African clawed frog) 335 100.00% Xenopus tropicalis (Western clawed frog) yap1 ARP50530_P050 E1CHM2_XENTR Yes‐associated protein 1 (Silurana tropicalis) 456 100.00% yap1 ARP50530_P050 D6C652_XENLA Yes‐associated protein 65 Xenopus laevis (African clawed frog) 459 92.00% yap1 ARP50530_P050 Q5M9A1_XENLA LOC496155 protein Xenopus laevis (African clawed frog) 381 78.00% WW domain containing transcription Xenopus tropicalis (Western clawed frog) yap1 ARP50530_P050 E1CHM3_XENTR regulator 1 (Silurana tropicalis) 390 78.00% Psme3 ARP46142_P050 Q6NTV2_XENLA Psme3 protein Xenopus laevis (African clawed frog) 254 85.00% Psme3 ARP46142_P050 Q640F3_XENLA Psme3b protein Xenopus laevis (African clawed frog) 254 85.00% Xenopus tropicalis (Western clawed frog) Psme3 ARP46142_P050 A4II64_XENTR Psme3 protein (Silurana tropicalis) 254 85.00% SMAD1 ARP32003_P050 Q91913_XENLA Mad1 protein Xenopus laevis (African clawed frog) 464 100.00% SMAD1 ARP32003_P050 Q91693_XENLA Mothers against DPP Xenopus laevis (African clawed frog) 464 100.00% SMAD1 ARP32003_P050 Q6PF32_XENLA Xmad protein Xenopus laevis (African clawed frog) 464 100.00% Xenopus tropicalis (Western clawed frog) SMAD1 ARP32003_P050 Q6DIS7_XENTR SMAD family member 1 (Silurana tropicalis) 464 100.00% SMAD1 ARP32003_P050 Q5HZ76_XENLA MADH1 protein Xenopus laevis (African clawed frog) 464 100.00% SMAD1 ARP32003_P050 P79947_XENLA Smad1.1 Xenopus laevis (African clawed frog) 467 100.00% ABCE1 ARP43633_P050 Q7ZWZ3_XENLA Abce1‐prov protein Xenopus laevis (African clawed frog) 599 92.00% ATP‐binding cassette, sub‐family E (OABP), Xenopus tropicalis (Western clawed frog) ABCE1 ARP43633_P050 Q6GL91_XENTR member 1 (Silurana tropicalis) 599 92.00% Xenopus tropicalis (Western clawed frog) CBX7 ARP34493_P050 Q6DEW3_XENTR MGC89524 protein (Silurana tropicalis) 245 85.00% LOC432087 ARP54293_P050 Q7ZYQ4_XENLA Fuca protein (Fragment) Xenopus laevis (African clawed frog) 460 90.00% LOC432087 ARP54293_P050 Q6IRC2_XENLA LOC432087 protein (Fragment) Xenopus laevis (African clawed frog) 458 90.00% LOC432087 ARP54293_P050 Q6GM64_XENLA Putative uncharacterized protein Xenopus laevis (African clawed frog) 456 90.00% Xenopus tropicalis (Western clawed frog) LOC432087 ARP54293_P050 Q5EAL9_XENTR Fucosidase, alpha‐L‐1, tissue (Silurana tropicalis) 459 90.00% LOC432087 ARP54293_P050 Q4FZX3_XENLA LOC432087 protein (Fragment) Xenopus laevis (African clawed frog) 450 90.00% LOC432087 ARP54293_P050 Q2VPI5_XENLA LOC432087 protein (Fragment) Xenopus laevis (African clawed frog) 457 90.00% Xenopus tropicalis (Western clawed frog) LOC432087 ARP54293_P050 Q28BL3_XENTR Fucosidase, alpha‐L‐1, tissue (Silurana tropicalis) 457 90.00% LOC432087 ARP54293_P050 A9UMN2_XENLA LOC432087 protein Xenopus laevis (African clawed frog) 463 90.00% LOC432087 ARP54293_P050 A3KMT8_XENLA LOC432087 protein (Fragment) Xenopus laevis (African clawed frog) 461 90.00% LOC432087 ARP54293_P050 A0AUS5_XENLA LOC432087 protein (Fragment) Xenopus laevis (African clawed frog) 457 90.00% LOC432087 ARP54293_P050 Q6PAZ5_XENLA MGC68702 protein Xenopus laevis (African clawed frog) 470 85.00% ORF Names:ACLA_029100 EMBL EAW08182.1OrganismAspergillus clavatus ARP48240_P050 Q6GNX3_XENLA Xdrg protein Xenopus laevis (African clawed frog) 334 85.00% ORF Names:ACLA_029100 EMBL EAW08182.1OrganismAspergillus Developmentally regulated GTP binding Xenopus tropicalis (Western clawed frog) clavatus ARP48240_P050 Q28G58_XENTR protein 1 (Silurana tropicalis) 367 85.00% ORF Names:ACLA_029100 EMBL EAW08182.1OrganismAspergillus Developmentally‐regulated GTP‐binding clavatus ARP48240_P050 DRG1_XENLA protein 1 (DRG‐1) (xDRG) Xenopus laevis (African clawed frog) 367 85.00% ARP38021_T100 A9UM32_XENLA LIM domain binding protein 1 Xenopus laevis (African clawed frog) 375 84.00% Xenopus tropicalis (Western clawed frog) ARP38021_T100 LDB1_XENTR LIM domain‐binding protein 1 (LDB‐1) (Silurana tropicalis) 373 84.00%

ARP38021_T100 LDB1_XENLA LIM domain‐binding protein 1 (LDB‐1) (xLdb1) Xenopus laevis (African clawed frog) 375 84.00% ARP38021_T100 LDB2_XENLA Isoform a Xenopus laevis (African clawed frog) 373 100.00%

ARP38021_T100 LDB2_XENLA LIM domain‐binding protein 2 (LDB‐2) (xLdb2) Xenopus laevis (African clawed frog) 398 100.00% Xenopus tropicalis (Western clawed frog) PREP ARP56413_P050 Q6P4W3_XENTR Prolyl endopeptidase (Silurana tropicalis) 712 85.00% ORF Names:Bm1_51035 EMBL EDP29234.1OrganismBrugia malayi Xenopus tropicalis (Western clawed frog) (Filarial nematode worm) ARP56017_P050 B0BMH9_XENTR LOC100145041 protein (Silurana tropicalis) 231 92.00% ORF Names:Bm1_51035 EMBL EDP29234.1OrganismBrugia malayi (Filarial nematode worm) ARP56017_P050 Q3KQ03_XENLA MGC131158 protein Xenopus laevis (African clawed frog) 231 85.00% E3 ubiquitin‐protein ligase HACE1 (EC 6.3.2.‐) (HECT domain and ankyrin repeat‐containing Xenopus tropicalis (Western clawed frog) obg ARP43277_P050 HACE1_XENTR E3 ubiquitin‐protein ligase 1) (Silurana tropicalis) 912 85.00% E3 ubiquitin‐protein ligase HACE1 (EC 6.3.2.‐) (HECT domain and ankyrin repeat‐containing obg ARP43277_P050 HACE1_XENLA E3 ubiquitin‐protein ligase 1) Xenopus laevis (African clawed frog) 944 85.00% ARP58324_P050 Q7ZXG1_XENLA Smarcd1 protein (Fragment) Xenopus laevis (African clawed frog) 481 100.00% SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily Xenopus tropicalis (Western clawed frog) ARP58324_P050 Q6GL18_XENTR d, member 1 (Silurana tropicalis) 508 100.00% ARP58324_P050 Q6DCP7_XENLA Smarcd1 protein (Fragment) Xenopus laevis (African clawed frog) 513 100.00% ARP58324_P050 Q66J25_XENLA Smarcd1 protein (Fragment) Xenopus laevis (African clawed frog) 504 100.00% ARP58324_P050 Q505N3_XENLA Smarcd1 protein (Fragment) Xenopus laevis (African clawed frog) 496 100.00% SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily Xenopus tropicalis (Western clawed frog) ARP58324_P050 Q28CT6_XENTR d, member 1 (Silurana tropicalis) 508 100.00% ARP58324_P050 A1A5J8_XENLA Smarcd1 protein Xenopus laevis (African clawed frog) 507 100.00%

Lysine‐specific demethylase 3A‐B (EC 1.14.11.‐ ORF Names:TRIADDRAFT_32600 EMBL ) (JmjC domain‐containing histone EDV20101.1OrganismTrichoplax demethylation protein 2A) (Jumonji domain‐ adhaerens (Trichoplax reptans) ARP39268_T100 KD3AB_XENLA containing protein 1A‐B) Xenopus laevis (African clawed frog) 1334 100.00%

Lysine‐specific demethylase 3A‐A (EC 1.14.11.‐ ORF Names:TRIADDRAFT_32600 EMBL ) (JmjC domain‐containing histone EDV20101.1OrganismTrichoplax demethylation protein 2A) (Jumonji domain‐ adhaerens (Trichoplax reptans) ARP39268_T100 KD3AA_XENLA containing protein 1A‐A) Xenopus laevis (African clawed frog) 1331 100.00% mizf ARP32543_P050 Q6GMA7_XENLA MGC81946 protein Xenopus laevis (African clawed frog) 444 85.00% mizf ARP32543_P050 Q6DEA7_XENLA MGC79058 protein Xenopus laevis (African clawed frog) 444 85.00% Histone H4 transcription factor (MBD2 (Methyl‐CpG‐binding protein)‐interacting zinc Xenopus tropicalis (Western clawed frog) mizf ARP32543_P050 Q5XGF3_XENTR finger protein) (Silurana tropicalis) 443 85.00%

ORF Names:v1g169754OrganismNematostel Xenopus tropicalis (Western clawed frog) la vectensis (Starlet sea anemone) ARP39452_P050 A4IIP6_XENTR LOC100125035 protein (Silurana tropicalis) 719 78.00%

ORF Names:v1g169754OrganismNematostel la vectensis (Starlet sea anemone) ARP39452_P050 KLH20_XENLA Kelch‐like protein 20 Xenopus laevis (African clawed frog) 604 90.00% ORF Names:zgc:163008 EMBL AAI41799.1 ZFIN ZDB‐GENE‐030131‐ 2671OrganismDanio rerio (Zebrafish) Xenopus tropicalis (Western clawed frog) (Brachydanio rerio) ARP39221_P050 A4IIP6_XENTR LOC100125035 protein (Silurana tropicalis) 719 78.00% ORF Names:zgc:163008 EMBL AAI41799.1 ZFIN ZDB‐GENE‐030131‐ 2671OrganismDanio rerio (Zebrafish) Influenza virus NS1A‐binding protein homolog (Brachydanio rerio) ARP39221_P050 NS1BP_XENLA (NS1‐BP) (NS1‐binding protein homolog) Xenopus laevis (African clawed frog) 638 76.00% ORF Names:zgc:163008 EMBL AAI41799.1 ZFIN ZDB‐GENE‐030131‐ 2671OrganismDanio rerio (Zebrafish) (Brachydanio rerio) ARP39221_P050 KLH20_XENLA Kelch‐like protein 20 Xenopus laevis (African clawed frog) 604 90.00% ORF Names:zgc:163008 EMBL AAI41799.1 ZFIN ZDB‐GENE‐030131‐ 2671OrganismDanio rerio (Zebrafish) (Brachydanio rerio) ARP39221_P050 Q6DE07_XENLA MGC80367 protein Xenopus laevis (African clawed frog) 635 75.00% ORF Names:zgc:163008 EMBL AAI41799.1 ZFIN ZDB‐GENE‐030131‐ 2671OrganismDanio rerio (Zebrafish) Xenopus tropicalis (Western clawed frog) (Brachydanio rerio) ARP39221_P050 Q66IL9_XENTR Kelch‐like 13 (Silurana tropicalis) 635 75.00% Xenopus tropicalis (Western clawed frog) Spo11 ARP54901_P050 Q66KK5_XENTR Spo11 protein (Silurana tropicalis) 373 76.00% Xenopus tropicalis (Western clawed frog) Abca2 ARP43733_T100 Q5YG24_XENTR Retinal‐specific ATP transporter ABCA4 (Silurana tropicalis) 2359 84.00% ORF Names:CG9650 EMBL ABW09352.2 FlyBase FBgn0029939, Dmel_CG9650 EMBL ABW09352.2OrganismDrosophila melanogaster (Fruit fly) ARP51085_P050 Q7SY91_XENLA Klf7‐prov protein Xenopus laevis (African clawed frog) 293 91.00% ORF Names:CG9650 EMBL ABW09352.2 FlyBase FBgn0029939, Dmel_CG9650 EMBL ABW09352.2OrganismDrosophila Xenopus tropicalis (Western clawed frog) melanogaster (Fruit fly) ARP51085_P050 Q6DIM6_XENTR Zinc finger protein 534 (Silurana tropicalis) 368 91.00% ORF Names:CG9650 EMBL ABW09352.2 FlyBase FBgn0029939, Dmel_CG9650 EMBL ABW09352.2OrganismDrosophila Xenopus tropicalis (Western clawed frog) melanogaster (Fruit fly) ARP51085_P050 Q0V9Z4_XENTR Putative uncharacterized protein MGC145688 (Silurana tropicalis) 594 84.00% ORF Names:CG9650 EMBL ABW09352.2 FlyBase FBgn0029939, Dmel_CG9650 EMBL ABW09352.2OrganismDrosophila Xenopus tropicalis (Western clawed frog) melanogaster (Fruit fly) ARP51085_P050 Q0IHT4_XENTR Kruppel‐like factor 7 (Ubiquitous) (Silurana tropicalis) 296 91.00% ORF Names:CG9650 EMBL ABW09352.2 FlyBase FBgn0029939, Dmel_CG9650 EMBL ABW09352.2OrganismDrosophila melanogaster (Fruit fly) ARP51085_P050 B1H1R1_XENLA LOC100158283 protein Xenopus laevis (African clawed frog) 602 84.00% Celf2 ARP40323_T100 B5LEQ4_XENLA RNA binding protein Bruno‐like 3b Xenopus laevis (African clawed frog) 493 100.00% Celf2 ARP40323_T100 CELF2_XENLA Isoform 2 Xenopus laevis (African clawed frog) 538 100.00% Celf2 ARP40323_T100 CEL1B_XENLA Isoform 2 Xenopus laevis (African clawed frog) 529 100.00% CUGBP Elav‐like family member 2 (CELF‐2) (Bruno‐like protein 3) (CUG triplet repeat RNA‐ binding protein 2) (CUG‐BP2) (CUG‐BP‐ and ETR‐3‐like factor 2) (ELAV‐type RNA‐binding protein 3) (ETR‐3) (RNA‐binding protein Xenopus tropicalis (Western clawed frog) Celf2 ARP40323_T100 CELF2_XENTR BRUNOL‐3) (Silurana tropicalis) 513 100.00% CUGBP Elav‐like family member 2 (CELF‐2) (Bruno‐like protein 3) (CUG triplet repeat RNA‐ binding protein 2) (CUG‐BP2) (CUG‐BP‐ and ETR‐3‐like factor 2) (ELAV‐type RNA‐binding protein 3) (ETR‐3) (RNA‐binding protein Celf2 ARP40323_T100 CELF2_XENLA BRUNOL‐3) Xenopus laevis (African clawed frog) 536 100.00% CUGBP Elav‐like family member 1 (CELF‐1) (Bruno‐like protein 2) (CUG triplet repeat RNA‐ binding protein 1) (CUG‐BP1) (CUG‐BP‐ and ETR‐3‐like factor 1) (RNA‐binding protein Xenopus tropicalis (Western clawed frog) Celf2 ARP40323_T100 CELF1_XENTR BRUNOL‐2) (Silurana tropicalis) 490 100.00%

CUGBP Elav‐like family member 1‐B (CELF‐1B) (Bruno‐like protein 2‐B) (CUG triplet repeat RNA‐binding protein 1‐B) (CUG‐BP1‐B) (CUG‐ BP‐ and ETR‐3‐like factor 1‐B) (Embryo deadenylation element‐binding protein B) (EDEN‐BP‐B) (RNA‐binding protein BRUNOL‐2‐ Celf2 ARP40323_T100 CEL1B_XENLA B) (p53/p55) Xenopus laevis (African clawed frog) 489 100.00%

CUGBP Elav‐like family member 1‐A (CELF‐1A) (Bruno‐like protein 2‐A) (CUG triplet repeat RNA‐binding protein 1‐A) (CUG‐BP1‐A) (CUG‐ BP‐ and ETR‐3‐like factor 1‐A) (Embryo deadenylation element‐binding protein A) (EDEN‐BP‐A) (RNA‐binding protein BRUNOL‐2‐ Celf2 ARP40323_T100 CEL1A_XENLA A) (p53/p55) Xenopus laevis (African clawed frog) 489 100.00%

ORF Names:v1g99103OrganismNematostell a vectensis (Starlet sea anemone) ARP53443_P050 Q8AVM2_XENLA Eif5‐prov protein Xenopus laevis (African clawed frog) 434 100.00%

ORF Names:v1g99103OrganismNematostell Xenopus tropicalis (Western clawed frog) a vectensis (Starlet sea anemone) ARP53443_P050 Q66II6_XENTR Eif5 protein (Silurana tropicalis) 431 100.00% LOC549358 ARP52512_P050 Q6GPE4_XENLA MGC80446 protein Xenopus laevis (African clawed frog) 383 91.00% Novel protein containing three WD domain, G‐ beta repeats (Putative uncharacterized Xenopus tropicalis (Western clawed frog) LOC549358 ARP52512_P050 Q28I78_XENTR protein LOC549358) (Silurana tropicalis) 383 100.00% Xenopus tropicalis (Western clawed frog) LOC549358 ARP52512_P050 B7ZU11_XENTR Putative uncharacterized protein LOC549358 (Silurana tropicalis) 383 100.00% ORF Names:TVAG_278990 EMBL EAX86858.1OrganismTrichomonas vaginalis ARP38242_P050 A1L3N5_XENLA LOC100037053 protein (SPIB‐b) Xenopus laevis (African clawed frog) 273 85.00% ORF Names:TVAG_278990 EMBL EAX86858.1OrganismTrichomonas MGC53020 protein (SPIB‐a) (Spi‐B vaginalis ARP38242_P050 Q9I8M5_XENLA transcription factor) Xenopus laevis (African clawed frog) 281 85.00% ORF Names:TVAG_278990 EMBL EAX86858.1OrganismTrichomonas Xenopus tropicalis (Western clawed frog) vaginalis ARP38242_P050 C0KXH8_XENTR SPIB (Silurana tropicalis) 273 85.00% Chn1 ARP51863_P050 Q6GNI5_XENLA MGC82782 protein Xenopus laevis (African clawed frog) 332 92.00% Chn1 ARP51863_P050 Q7T0N5_XENLA Chn1‐prov protein Xenopus laevis (African clawed frog) 459 92.00% Xenopus tropicalis (Western clawed frog) Chn1 ARP51863_P050 B1H2N7_XENTR Chn1 protein (Silurana tropicalis) 334 92.00% MGC53020 protein (SPIB‐a) (Spi‐B ARP38241_P050 Q9I8M5_XENLA transcription factor) Xenopus laevis (African clawed frog) 281 85.00% Xenopus tropicalis (Western clawed frog) ARP38241_P050 C0KXH8_XENTR SPIB (Silurana tropicalis) 273 85.00% Xenopus tropicalis (Western clawed frog) ARP38241_P050 Q4V790_XENTR LOC613064 protein (Fragment) (Silurana tropicalis) 313 85.00% Xenopus tropicalis (Western clawed frog) ARP38241_P050 Q0P4Z3_XENTR Spi1 protein (Fragment) (Silurana tropicalis) 314 85.00% Xenopus tropicalis (Western clawed frog) ARP38241_P050 C0LVA2_XENTR SPI1 ETS transcription factor (Silurana tropicalis) 266 85.00% ARP38241_P050 A1L3N5_XENLA LOC100037053 protein (SPIB‐b) Xenopus laevis (African clawed frog) 273 78.00% STK38 ARP48727_P050 Q7T0M1_XENLA Trc‐prov protein Xenopus laevis (African clawed frog) 465 92.00% STK38 ARP48727_P050 Q6NTL3_XENLA MGC83214 protein Xenopus laevis (African clawed frog) 464 92.00% Xenopus tropicalis (Western clawed frog) STK38 ARP48727_P050 Q6DIL2_XENTR Serine/threonine kinase 38 like (Silurana tropicalis) 464 92.00% Novel zinc knuckle containing protein ORF Names:OsI_27673OrganismOryza (Ortholog of human step II splicing factor Xenopus tropicalis (Western clawed frog) sativa subsp. indica (Rice) ARP52179_P050 Q28EK5_XENTR SLU7) (Fragment) (Silurana tropicalis) 493 100.00%

ORF Names:OsI_27673OrganismOryza Xenopus tropicalis (Western clawed frog) sativa subsp. indica (Rice) ARP52179_P050 B1H152_XENTR Slu7 protein (Fragment) (Silurana tropicalis) 478 100.00%

ORF Names:OsI_27673OrganismOryza sativa subsp. indica (Rice) ARP52179_P050 SLU7_XENLA Pre‐mRNA‐splicing factor SLU7 Xenopus laevis (African clawed frog) 580 100.00% ARP41200_P050 Q66IX3_XENLA MGC84222 protein Xenopus laevis (African clawed frog) 197 84.00% RNA‐binding protein with multiple splicing (RBP‐MS) (Heart and RRM expressed ARP41200_P050 RBPMS_XENLA sequence) (Hermes) Xenopus laevis (African clawed frog) 196 84.00% PATZ1_1 ARP39078_P050 Q569U4_XENLA LOC733194 protein (Fragment) Xenopus laevis (African clawed frog) 563 77.00% Xenopus tropicalis (Western clawed frog) B3galt6 ARP50258_P050 Q5BL85_XENTR Putative uncharacterized protein LOC548849 (Silurana tropicalis) 343 76.00% UDP‐Gal:betaGal beta 1,3‐ Xenopus tropicalis (Western clawed frog) B3galt6 ARP50258_P050 Q28F44_XENTR galactosyltransferase polypeptide 6 (Silurana tropicalis) 343 76.00% ARP34440_P050 Q90YE4_XENLA Homeobox protein, Hoxd9 (Fragment) Xenopus laevis (African clawed frog) 248 90.00% ARP34440_P050 A0JMS5_XENLA Putative uncharacterized protein Xenopus laevis (African clawed frog) 273 90.00% ARP43599_T100 Q6AZP0_XENLA MGC83056 protein Xenopus laevis (African clawed frog) 672 78.00% ARP43599_T100 Q9PUN0_XENLA Metastasis associated 1‐like protein Xenopus laevis (African clawed frog) 670 86.00% ARP43599_T100 Q4V7T0_XENLA Mta2 protein Xenopus laevis (African clawed frog) 669 86.00% Snx5 ARP55050_P050 Q6P7J4_XENLA MGC68551 protein Xenopus laevis (African clawed frog) 400 92.00% Xenopus tropicalis (Western clawed frog) Snx5 ARP55050_P050 Q28F22_XENTR 5 (Silurana tropicalis) 400 92.00% Snx5 ARP55050_P050 Q5HZZ2_XENLA LOC496311 protein Xenopus laevis (African clawed frog) 400 85.00% RUNX1 P100746_P050 RUNX1_XENLA Isoform 2 Xenopus laevis (African clawed frog) 476 78.00%

Runt‐related transcription factor 1 (Acute myeloid leukemia 1 protein) (XAML) (Core‐ RUNX1 P100746_P050 RUNX1_XENLA binding factor subunit alpha‐2) (CBF‐alpha‐2) Xenopus laevis (African clawed frog) 462 78.00% Xenopus tropicalis (Western clawed frog) MPP7 ARP53247_P050 MPP7_XENTR MAGUK p55 subfamily member 7 (Silurana tropicalis) 576 100.00% Cdc20 AVARP03031_P050 Q8AVG7_XENLA Cdc20 protein Xenopus laevis (African clawed frog) 506 100.00% Cdc20 AVARP03031_P050 Q7ZX45_XENLA LOC398044 protein (Fragment) Xenopus laevis (African clawed frog) 492 100.00%

CDC20 cell division cycle 20 homolog (S. Xenopus tropicalis (Western clawed frog) Cdc20 AVARP03031_P050 Q6P867_XENTR cerevisiae) (Cell division cycle 20 homolog) (Silurana tropicalis) 507 100.00% Cdc20 AVARP03031_P050 Q6DFD4_XENLA LOC398044 protein Xenopus laevis (African clawed frog) 507 100.00% Cdc20 AVARP03031_P050 O93289_XENLA Fizzy1 Xenopus laevis (African clawed frog) 507 100.00% ECA4 ARP45159_P050 Q7ZXY6_XENLA Ca‐p60a‐prov protein Xenopus laevis (African clawed frog) 996 100.00% ECA4 ARP45159_P050 Q5U4T2_XENLA LOC495440 protein Xenopus laevis (African clawed frog) 1033 100.00% Xenopus tropicalis (Western clawed frog) ECA4 ARP45159_P050 Q4VA67_XENTR Putative uncharacterized protein mgc107776 (Silurana tropicalis) 994 100.00% ECA4 ARP45159_P050 Q4KLX4_XENLA LOC495046 protein Xenopus laevis (African clawed frog) 1042 100.00% Xenopus tropicalis (Western clawed frog) ECA4 ARP45159_P050 Q0V9S4_XENTR ATPase, Ca++ transporting, ubiquitous (Silurana tropicalis) 1033 100.00% Xenopus tropicalis (Western clawed frog) ECA4 ARP45159_P050 B3DL64_XENTR ATPase, Ca++ transporting, ubiquitous (Silurana tropicalis) 1033 100.00% ECA4 ARP45159_P050 A2RV57_XENLA ATP2A2 protein Xenopus laevis (African clawed frog) 1042 100.00% kiaa0182 ARP55092_P050 A1L1G6_XENLA LOC100036836 protein Xenopus laevis (African clawed frog) 1218 100.00% Xenopus tropicalis (Western clawed frog) FUT7 ARP48467_P050 A8E4W7_XENTR LOC100127585 protein (Silurana tropicalis) 359 84.00% Xenopus tropicalis (Western clawed frog) FUT7 ARP48467_P050 Q6EV11_XENTR Alpha3‐fucosyltransferase (Silurana tropicalis) 349 78.00% Xenopus tropicalis (Western clawed frog) FUT7 ARP48467_P050 Q0VFC9_XENTR Putative uncharacterized protein (Silurana tropicalis) 349 78.00% Alpha 1,3/4 fucosyltransferase Lewis 1 Xenopus tropicalis (Western clawed frog) FUT7 ARP48467_P050 Q6WNG2_XENTR (Fragment) (Silurana tropicalis) 280 100.00% Xenopus tropicalis (Western clawed frog) FUT7 ARP48467_P050 A9UMB6_XENTR LOC100135300 protein (Silurana tropicalis) 369 76.00% FUT7 ARP48467_P050 Q8UWC2_XENLA XFUT9 Xenopus laevis (African clawed frog) 359 75.00% Xenopus tropicalis (Western clawed frog) FUT7 ARP48467_P050 Q6EV12_XENTR Alpha3‐fucosyltransferase (Silurana tropicalis) 363 75.00% Xenopus tropicalis (Western clawed frog) FUT7 ARP48467_P050 Q5F2N6_XENTR Alpha3‐fucosyltransferase (Silurana tropicalis) 359 75.00% Xenopus tropicalis (Western clawed frog) FUT7 ARP48467_P050 Q0IIV3_XENTR Alpha3‐fucosyltransferase (Silurana tropicalis) 359 75.00% DEAD (Asp‐Glu‐Ala‐Asp) box polypeptide 23 Xenopus tropicalis (Western clawed frog) DDX23 ARP36376_T100 Q28IF2_XENTR (Fragment) (Silurana tropicalis) 139 100.00% Xenopus tropicalis (Western clawed frog) DDX23 ARP36376_T100 A8E5R7_XENTR LOC549967 protein (Fragment) (Silurana tropicalis) 319 100.00% ORF Names:GSPATT00003626001 EMBL CAK90763.1OrganismParamecium tetraurelia ARP58012_P050 Q8AVM8_XENLA Ube2k protein Xenopus laevis (African clawed frog) 200 100.00% ORF Names:GSPATT00003626001 EMBL CAK90763.1OrganismParamecium Ubiquitin‐conjugating enzyme E2K (UBC1 Xenopus tropicalis (Western clawed frog) tetraurelia ARP58012_P050 Q6GL28_XENTR homolog) (Silurana tropicalis) 200 100.00% ORF Names:GSPATT00003626001 EMBL CAK90763.1OrganismParamecium Xenopus tropicalis (Western clawed frog) tetraurelia ARP58012_P050 B0JZQ9_XENTR LOC100145219 protein (Silurana tropicalis) 200 100.00% Eif2s3x ARP46056_T100 Q7ZY57_XENLA Eif2s3‐prov protein Xenopus laevis (African clawed frog) 472 92.00% Eukaryotic translation initiation factor 2, Xenopus tropicalis (Western clawed frog) Eif2s3x ARP46056_T100 Q5I098_XENTR subunit 3 gamma, 52kDa (Silurana tropicalis) 472 92.00% Guanine nucleotide binding protein, alpha Xenopus tropicalis (Western clawed frog) ARP41764_T100 Q6NVN4_XENTR stimulating, olfactory type (Silurana tropicalis) 379 84.00% MGC68706 protein (Putative uncharacterized ARP41764_T100 Q6P413_XENLA protein MGC68706) Xenopus laevis (African clawed frog) 379 76.00% ARP41764_T100 B7ZR45_XENLA GNAS complex locus Xenopus laevis (African clawed frog) 379 76.00% Guanine nucleotide‐binding protein G(s) subunit alpha (Adenylate cyclase‐stimulating ARP41764_T100 GNAS_XENLA G alpha protein) Xenopus laevis (African clawed frog) 379 76.00%

Ectonucleotide pyrophosphatase/phosphodiesterase family Enpp6 ARP53158_P050 ENPP6_XENLA member 6 (E‐NPP 6) (NPP‐6) (EC 3.1.‐.‐) Xenopus laevis (African clawed frog) 441 85.00% Xenopus tropicalis (Western clawed frog) Enpp6 ARP53158_P050 D3TZC6_XENTR Ectonucleotidase enpp6 (Silurana tropicalis) 438 84.00% ARP41717_P050 Q6DKC5_XENLA MGC84152 protein Xenopus laevis (African clawed frog) 265 92.00% ARP41717_P050 Q804V6_XENLA Cardiac troponin T Xenopus laevis (African clawed frog) 272 92.00% ARP41717_P050 Q804V5_XENLA Cardiac troponin T Xenopus laevis (African clawed frog) 261 92.00% ARP41717_P050 Q66L29_XENLA LOC446916 protein (Fragment) Xenopus laevis (African clawed frog) 179 92.00% ARP41717_P050 Q3B8A3_XENLA Putative uncharacterized protein Xenopus laevis (African clawed frog) 272 92.00% ARP41717_P050 B1WBB0_XENLA Putative uncharacterized protein Xenopus laevis (African clawed frog) 241 92.00% ARP41717_P050 Q7ZXG9_XENLA Tnnt3a protein Xenopus laevis (African clawed frog) 276 78.00% ARP41717_P050 Q7T2Z8_XENLA Fast troponin T Xenopus laevis (African clawed frog) 276 78.00% ARP41717_P050 Q71N35_XENLA Troponin T3 Xenopus laevis (African clawed frog) 273 78.00% ARP41717_P050 Q32N26_XENLA Tnnt3a protein Xenopus laevis (African clawed frog) 273 78.00% ARP41717_P050 A8E5Y2_XENLA Putative uncharacterized protein Xenopus laevis (African clawed frog) 244 78.00% Xenopus tropicalis (Western clawed frog) prx1 ARP48454_P050 Q5XH88_XENTR Peroxiredoxin 1 (Silurana tropicalis) 199 78.00% Xenopus tropicalis (Western clawed frog) prx1 ARP48454_P050 B0JZS0_XENTR LOC100145226 protein (Silurana tropicalis) 201 78.00% Probable E3 ubiquitin‐protein ligase makorin‐ Xenopus tropicalis (Western clawed frog) MKRN2 ARP43144_P050 MKRN2_XENTR 2 (EC 6.3.2.‐) (Silurana tropicalis) 418 86.00% MKRN2 ARP43144_P050 Q3KQ17_XENLA MGC131105 protein Xenopus laevis (African clawed frog) 409 80.00% Probable E3 ubiquitin‐protein ligase makorin‐ MKRN2 ARP43144_P050 MKRN2_XENLA 2 (EC 6.3.2.‐) Xenopus laevis (African clawed frog) 409 80.00% Ubxn4 ARP47620_T100 Q6DD25_XENLA UBXD2 protein (Fragment) Xenopus laevis (African clawed frog) 531 85.00% hk2 ARP54303_P050 Q9DDT4_XENLA I (Fragment) Xenopus laevis (African clawed frog) 643 85.00% hk2 ARP54303_P050 Q6GQB4_XENLA Hk1‐A protein Xenopus laevis (African clawed frog) 916 85.00% Xenopus tropicalis (Western clawed frog) hk2 ARP54303_P050 A4II49_XENTR Hk1 protein (Silurana tropicalis) 917 85.00% Xenopus tropicalis (Western clawed frog) hk2 ARP54303_P050 B1WAR7_XENTR LOC100145699 protein (Silurana tropicalis) 915 78.00% hk2 ARP54303_P050 A1L2H2_XENLA LOC100036846 protein Xenopus laevis (African clawed frog) 913 78.00% hk2 ARP54303_P050 Q91753_XENLA Glucokinase Xenopus laevis (African clawed frog) 458 78.00% Xenopus tropicalis (Western clawed frog) hk2 ARP54303_P050 A4IHW0_XENTR LOC100124905 protein (Silurana tropicalis) 458 78.00%

ARP45387_P050 Q561L4_XENLA Putative uncharacterized protein (Fragment) Xenopus laevis (African clawed frog) 447 100.00% Xenopus tropicalis (Western clawed frog) ARP45387_P050 A4IJ13_XENTR LOC100125100 protein (Silurana tropicalis) 656 100.00%

LOC549100 ARP41593_P050 CK054_XENLA Ester hydrolase C11orf54 homolog (EC 3.1.‐.‐) Xenopus laevis (African clawed frog) 316 92.00% Xenopus tropicalis (Western clawed frog) LOC549100 ARP41593_P050 A4IHG7_XENTR LOC549100 protein (Silurana tropicalis) 316 84.00% Xenopus tropicalis (Western clawed frog) LOC549100 ARP41593_P050 CK054_XENTR Ester hydrolase C11orf54 homolog (EC 3.1.‐.‐) (Silurana tropicalis) 313 84.00% BB_r111_jsm90EE7f ARP43023_P050 Q6AZI4_XENLA LOC446231 protein (Fragment) Xenopus laevis (African clawed frog) 153 100.00% Xenopus tropicalis (Western clawed frog) BB_r111_jsm90EE7f ARP43023_P050 Q5BJ50_XENTR Ubiquitin‐conjugating enzyme E2L 3 (Silurana tropicalis) 154 100.00% BB_r111_jsm90EE7f ARP43023_P050 Q4QR35_XENLA LOC446231 protein Xenopus laevis (African clawed frog) 154 100.00% ORF Names:OsJ_03530 EMBL EAZ13614.1OrganismOryza sativa Glutamic‐oxaloacetic transaminase 1, soluble Xenopus tropicalis (Western clawed frog) subsp. japonica (Rice) ARP48205_T100 Q6NX26_XENTR (Aspartate aminotransferase 1) (Silurana tropicalis) 411 92.00% ORF Names:OsJ_03530 EMBL EAZ13614.1OrganismOryza sativa subsp. japonica (Rice) ARP48205_T100 Q7ZTK9_XENLA Xr406 protein Xenopus laevis (African clawed frog) 411 92.00% ORF Names:OsJ_03530 EMBL EAZ13614.1OrganismOryza sativa subsp. japonica (Rice) ARP48205_T100 Q7SZS3_XENLA Got2 protein Xenopus laevis (African clawed frog) 427 76.00% Phosphate cytidylyltransferase 2, Xenopus tropicalis (Western clawed frog) Pcyt2 ARP43576_T100 Q5M8H6_XENTR ethanolamine (Silurana tropicalis) 381 92.00% Pcyt2 ARP43576_T100 Q6DKC3_XENLA MGC84177 protein Xenopus laevis (African clawed frog) 383 92.00% ORF Names:zgc:172183 EMBL AAI54575.1 ZFIN ZDB‐GENE‐080204‐ 57OrganismDanio rerio (Zebrafish) (Brachydanio rerio) ARP34432_P050 MRF_XENLA Myelin gene regulatory factor Xenopus laevis (African clawed frog) 1092 100.00% ORF Names:PANDA_006233 EMBL EFB23912.1OrganismAiluropoda melanoleuca (Giant panda) ARP52586_P050 Q5EAV9_XENLA MGC85020 protein Xenopus laevis (African clawed frog) 184 78.00% ORF Names:PANDA_006233 EMBL EFB23912.1OrganismAiluropoda Novel protein (Putative uncharacterized Xenopus tropicalis (Western clawed frog) melanoleuca (Giant panda) ARP52586_P050 Q28GQ6_XENTR protein LOC733548) (Silurana tropicalis) 184 78.00% Xenopus tropicalis (Western clawed frog) ARP41425_T100 Q5M8I7_XENTR Hypothetical LOC496742 (Silurana tropicalis) 485 100.00% LOC100126640 protein (Putative ARP41425_T100 A8E606_XENLA uncharacterized protein LOC100126640) Xenopus laevis (African clawed frog) 485 100.00% mraY ARP43338_P050 RN170_XENLA RING finger protein 170 Xenopus laevis (African clawed frog) 257 100.00% Xenopus tropicalis (Western clawed frog) mraY ARP43338_P050 RN170_XENTR RING finger protein 170 (Silurana tropicalis) 257 85.00% TXNIP ARP52193_P050 Q6DED2_XENLA MGC78889 protein Xenopus laevis (African clawed frog) 388 100.00% ORF Names:v1g247177OrganismNematostel MGC89748 protein (Small nuclear Xenopus tropicalis (Western clawed frog) la vectensis (Starlet sea anemone) ARP40532_P050 Q6DDC4_XENTR ribonucleoprotein D2 polypeptide 16.5kDa) (Silurana tropicalis) 118 100.00%

ORF Names:v1g247177OrganismNematostel la vectensis (Starlet sea anemone) ARP40532_P050 Q5HZQ7_XENLA Putative uncharacterized protein Xenopus laevis (African clawed frog) 118 100.00% LOC100037031 AVARP09016_T100 A1L3K3_XENLA LOC100037031 protein (Fragment) Xenopus laevis (African clawed frog) 269 100.00% LOC100037031 AVARP09016_T100 Q6AZV1_XENLA Hsp90beta (Hsp90beta protein) Xenopus laevis (African clawed frog) 722 78.00% Heat shock protein 90kDa alpha (Cytosolic), Xenopus tropicalis (Western clawed frog) LOC100037031 AVARP09016_T100 Q5BL42_XENTR class B member 1 (Silurana tropicalis) 723 78.00% ORF Names:zgc:110717 EMBL AAI52124.1 ZFIN ZDB‐GENE‐050417‐ 47OrganismDanio rerio (Zebrafish) (Brachydanio rerio) ARP40796_T100 Q6DDU3_XENLA Exosc7‐prov protein Xenopus laevis (African clawed frog) 291 85.00% ORF Names:zgc:110717 EMBL AAI52124.1 ZFIN ZDB‐GENE‐050417‐ 47OrganismDanio rerio (Zebrafish) Xenopus tropicalis (Western clawed frog) (Brachydanio rerio) ARP40796_T100 Q5I0A3_XENTR LOC496941 protein (Fragment) (Silurana tropicalis) 289 78.00% ORF Names:zgc:110717 EMBL AAI52124.1 ZFIN ZDB‐GENE‐050417‐ 47OrganismDanio rerio (Zebrafish) Xenopus tropicalis (Western clawed frog) (Brachydanio rerio) ARP40796_T100 Q28JA6_XENTR Exosome component 7 (Silurana tropicalis) 291 78.00% ORF Names:zgc:110717 EMBL AAI52124.1 ZFIN ZDB‐GENE‐050417‐ 47OrganismDanio rerio (Zebrafish) Xenopus tropicalis (Western clawed frog) (Brachydanio rerio) ARP40796_T100 Q0IIZ7_XENTR Hypothetical LOC496941 (Silurana tropicalis) 291 78.00% ORF Names:zgc:110717 EMBL AAI52124.1 ZFIN ZDB‐GENE‐050417‐ 47OrganismDanio rerio (Zebrafish) Xenopus tropicalis (Western clawed frog) (Brachydanio rerio) ARP40796_T100 B4F6R8_XENTR Putative uncharacterized protein (Silurana tropicalis) 291 78.00% TATA box‐binding protein‐like protein 1 (TBP‐ like protein 1) (TATA box‐binding protein‐ related factor 2) (TBP‐related factor 2) (TBP‐ Xenopus tropicalis (Western clawed frog) ARP35751_T100 TBPL1_XENTR like factor) (Silurana tropicalis) 186 92.00% TATA box‐binding protein‐like protein 1 (TBP‐ like protein 1) (TATA box‐binding protein‐ related factor 2) (TBP‐related factor 2) (TBP‐ ARP35751_T100 TBPL1_XENLA like factor) (xlTLF) Xenopus laevis (African clawed frog) 186 92.00% glmnl ARP52485_P050 Q6PCE9_XENLA MGC69174 protein Xenopus laevis (African clawed frog) 600 92.00% ORF Names:MGG_00780 EMBL EDK02563.1OrganismMagnaporthe oryzae (strain 70‐15 / FGSC 8958) (Rice blast fungus) (Pyricularia oryzae) P100960_T100 Q6NTX9_XENLA MGC81442 protein Xenopus laevis (African clawed frog) 128 100.00%

ORF Names:MGG_00780 EMBL EDK02563.1OrganismMagnaporthe oryzae (strain 70‐15 / FGSC 8958) (Rice Activated RNA polymerase II transcription Xenopus tropicalis (Western clawed frog) blast fungus) (Pyricularia oryzae) P100960_T100 Q6DJR3_XENTR cofactor 4 (Silurana tropicalis) 128 100.00% Xenopus tropicalis (Western clawed frog) wdc146 ARP44527_P050 Q28ER9_XENTR WD repeat domain 33 (Silurana tropicalis) 245 100.00% Xenopus tropicalis (Western clawed frog) wdc146 ARP44527_P050 Q0VFU7_XENTR Putative uncharacterized protein (Fragment) (Silurana tropicalis) 299 100.00% Xenopus tropicalis (Western clawed frog) wdc146 ARP44527_P050 B4F6S7_XENTR LOC548794 protein (Silurana tropicalis) 1598 100.00% wdc146 ARP44527_P050 A9JS58_XENLA LOC100127314 protein (Fragment) Xenopus laevis (African clawed frog) 305 100.00% PEPD ARP56088_P050 Q7SY64_XENLA MGC64570 protein Xenopus laevis (African clawed frog) 498 78.00% arrb2 ARP48007_P050 Q6GPY2_XENLA MGC82523 protein Xenopus laevis (African clawed frog) 408 92.00% arrb2 ARP48007_P050 A5J090_XENLA Beta‐arrestin 2 Xenopus laevis (African clawed frog) 408 92.00% Xenopus tropicalis (Western clawed frog) arrb2 ARP48007_P050 A4QNQ6_XENTR Arrb2 protein (Silurana tropicalis) 408 92.00% arrb2 ARP48007_P050 Q641D8_XENLA MGC81940 protein Xenopus laevis (African clawed frog) 412 85.00% arrb2 ARP48007_P050 Q6DFC4_XENLA Arrb1‐prov protein Xenopus laevis (African clawed frog) 408 85.00%

ORF Names:v1g160342OrganismNematostel Xenopus tropicalis (Western clawed frog) la vectensis (Starlet sea anemone) ARP52491_P050 Q5M8M0_XENTR Calcium and integrin binding family member 3 (Silurana tropicalis) 207 92.00% Xenopus tropicalis (Western clawed frog) Mtx2 ARP51788_P050 Q6GUH5_XENTR Metaxin 2 (Silurana tropicalis) 274 78.00% Xenopus tropicalis (Western clawed frog) ARP55174_P050 Q66KJ6_XENTR FCHO1 protein (Fragment) (Silurana tropicalis) 542 92.00% Phox2b ARP31726_P050 Q6UEE0_XENLA Homeodomain protein (Phox2a protein) Xenopus laevis (African clawed frog) 281 80.00% Phox2b ARP31726_P050 Q6UED8_XENLA Homeodomain protein Xenopus laevis (African clawed frog) 293 91.00% Phox2b ARP31726_P050 Q5XGX2_XENLA LOC495120 protein Xenopus laevis (African clawed frog) 293 91.00% Xenopus tropicalis (Western clawed frog) Phox2b ARP31726_P050 B1WBH8_XENTR Phox2b protein (Silurana tropicalis) 293 91.00%

ORF Names:v1g177378OrganismNematostel Guanine nucleotide‐binding protein Gi alpha la vectensis (Starlet sea anemone) ARP54632_P050 O93565_XENLA subunit (Fragment) Xenopus laevis (African clawed frog) 350 100.00% ORF Names:v1g177378OrganismNematostel Xenopus tropicalis (Western clawed frog) la vectensis (Starlet sea anemone) ARP54632_P050 Q6P3M7_XENTR Putative uncharacterized protein MGC76300 (Silurana tropicalis) 355 85.00%

ORF Names:v1g177378OrganismNematostel la vectensis (Starlet sea anemone) ARP54632_P050 Q5U4X0_XENLA Gnai3 protein Xenopus laevis (African clawed frog) 355 85.00% Xenopus tropicalis (Western clawed frog) LOC100144994 ARP55456_P050 B0BM92_XENTR LOC100144994 protein (Fragment) (Silurana tropicalis) 541 100.00%

ORF Names:v1g200530OrganismNematostel la vectensis (Starlet sea anemone) ARP54765_P050 Q7T0N8_XENLA Hadhsc‐prov protein Xenopus laevis (African clawed frog) 313 92.00%

ORF L‐3‐hydroxyacyl‐Coenzyme A dehydrogenase, Names:v1g200530OrganismNematostel short chain (Short chain 3‐hydroxyacyl‐CoA Xenopus tropicalis (Western clawed frog) la vectensis (Starlet sea anemone) ARP54765_P050 Q5XGI2_XENTR dehydrogenase, mitochondrial) (Silurana tropicalis) 313 92.00% Xenopus tropicalis (Western clawed frog) Spop ARP50348_P050 A9UMC2_XENTR LOC100135306 protein (Silurana tropicalis) 374 100.00% Xenopus tropicalis (Western clawed frog) Spop ARP50348_P050 SPOP_XENTR Speckle‐type POZ protein (Silurana tropicalis) 374 100.00% Spop ARP50348_P050 SPOPB_XENLA Speckle‐type POZ protein B Xenopus laevis (African clawed frog) 374 100.00% Spop ARP50348_P050 SPOPA_XENLA Speckle‐type POZ protein A Xenopus laevis (African clawed frog) 374 100.00% hspbap1 ARP33578_P050 Q3KPZ5_XENLA LOC733353 protein (Fragment) Xenopus laevis (African clawed frog) 445 85.00% hspbap1 ARP33578_P050 A4QNS2_XENLA LOC733353 protein Xenopus laevis (African clawed frog) 446 85.00% GTF2H1 P100929_P050 Q7ZX12_XENLA Gtf2h1‐prov protein Xenopus laevis (African clawed frog) 532 78.00% General transcription factor IIH, polypeptide Xenopus tropicalis (Western clawed frog) GTF2H1 P100929_P050 Q6DIF6_XENTR 1, 62kDa (Silurana tropicalis) 547 78.00% GTF2H1 P100929_P050 Q5HZS8_XENLA Putative uncharacterized protein Xenopus laevis (African clawed frog) 172 78.00% SERPINB5 ARP42055_T100 Q7SYX2_XENLA MGC64421 protein Xenopus laevis (African clawed frog) 379 84.00% peptidase inhibitor, clade B Xenopus tropicalis (Western clawed frog) SERPINB5 ARP42055_T100 Q66KE4_XENTR (Ovalbumin), member 6 (Silurana tropicalis) 379 84.00% ORF Names:OsI_35503 EMBL EAY80334.1OrganismOryza sativa Xenopus tropicalis (Western clawed frog) subsp. indica (Rice) ARP41786_P050 Q5I0S0_XENTR Alcohol dehydrogenase 6 (Class V) (Silurana tropicalis) 376 92.00% ORF Names:OsI_35503 EMBL EAY80334.1OrganismOryza sativa subsp. indica (Rice) ARP41786_P050 Q6P7G1_XENLA MGC68507 protein Xenopus laevis (African clawed frog) 376 92.00% ORF Names:OsI_35503 EMBL EAY80334.1OrganismOryza sativa Xenopus tropicalis (Western clawed frog) subsp. indica (Rice) ARP41786_P050 Q5BKM0_XENTR MGC107857 protein (Silurana tropicalis) 376 92.00% ORF Names:OsI_35503 EMBL EAY80334.1OrganismOryza sativa subsp. indica (Rice) ARP41786_P050 Q6AZL8_XENLA Adh6‐prov protein Xenopus laevis (African clawed frog) 378 85.00% ORF Names:OsI_35503 EMBL EAY80334.1OrganismOryza sativa subsp. indica (Rice) ARP41786_P050 Q6IRQ3_XENLA MGC82221 protein Xenopus laevis (African clawed frog) 377 85.00% ORF Names:OsI_35503 EMBL EAY80334.1OrganismOryza sativa Alcohol dehydrogenase 5 (Class III), chi Xenopus tropicalis (Western clawed frog) subsp. indica (Rice) ARP41786_P050 Q5HZT1_XENTR polypeptide (Hypothetical LOC497007) (Silurana tropicalis) 376 85.00% ORF Names:OsI_35503 EMBL EAY80334.1OrganismOryza sativa subsp. indica (Rice) ARP41786_P050 Q6DKD6_XENLA MGC83376 protein Xenopus laevis (African clawed frog) 378 78.00% ORF Names:OsI_35503 EMBL EAY80334.1OrganismOryza sativa Alcohol dehydrogenase IB (Class I), beta Xenopus tropicalis (Western clawed frog) subsp. indica (Rice) ARP41786_P050 Q5I0R0_XENTR polypeptide (Silurana tropicalis) 378 78.00% ORF Names:OsI_35503 EMBL EAY80334.1OrganismOryza sativa Alcohol dehydrogenase class I (EC 1.1.1.1) subsp. indica (Rice) ARP41786_P050 O93331_XENLA (Fragment) Xenopus laevis (African clawed frog) 271 78.00% ORF Names:OsI_35503 EMBL EAY80334.1OrganismOryza sativa subsp. indica (Rice) ARP41786_P050 Q6EE34_XENLA Alcohol dehydrogenase 5 (Fragment) Xenopus laevis (African clawed frog) 376 78.00% ORF Names:OsI_35503 EMBL EAY80334.1OrganismOryza sativa Adh3 protein (Alcohol dehydrogenase class 3) subsp. indica (Rice) ARP41786_P050 Q4V813_XENLA (EC 1.1.1.1) Xenopus laevis (African clawed frog) 376 78.00% Xenopus tropicalis (Western clawed frog) Ythdf2 ARP55530_P050 B1H2Z7_XENTR LOC100145519 protein (Silurana tropicalis) 572 92.00% Ythdf2 ARP55530_P050 Q66J89_XENLA MGC81605 protein Xenopus laevis (African clawed frog) 572 92.00% Xenopus tropicalis (Western clawed frog) Fbxl16 ARP53165_P050 A4IIL8_XENTR LOC100125019 protein (Silurana tropicalis) 497 100.00% ctnnb1 AVARP14001_T100 Q7ZX35_XENLA Ctnnb1‐prov protein Xenopus laevis (African clawed frog) 781 100.00% ctnnb1 AVARP14001_T100 Q63ZT4_XENLA Beta‐catenin protein Xenopus laevis (African clawed frog) 781 100.00% Catenin (Cadherin associated protein), beta 1, 88kDa (Catenin (Cadherin‐associated protein), Xenopus tropicalis (Western clawed frog) ctnnb1 AVARP14001_T100 Q28GC2_XENTR beta 1, 88kDa) (Silurana tropicalis) 781 100.00% ctnnb1 AVARP14001_T100 A1A5I6_XENLA Ctnnb1 protein Xenopus laevis (African clawed frog) 780 100.00% ctnnb1 AVARP14001_T100 CTNB_XENLA Catenin beta (Beta‐catenin) Xenopus laevis (African clawed frog) 781 100.00% DSCR1 ARP38457_P050 Q7ZXP4_XENLA Dscr1‐prov protein Xenopus laevis (African clawed frog) 231 92.00% DSCR1 ARP38457_P050 Q7T0U1_XENLA MGC68988 protein Xenopus laevis (African clawed frog) 199 92.00% Xenopus tropicalis (Western clawed frog) DSCR1 ARP38457_P050 Q6DK90_XENTR Regulator of calcineurin 1 (Silurana tropicalis) 199 92.00% DSCR1 ARP38457_P050 Q4V7V2_XENLA MGC68988 protein Xenopus laevis (African clawed frog) 80 92.00% Xenopus tropicalis (Western clawed frog) DSCR1 ARP38457_P050 Q28HQ3_XENTR Down syndrome critical region gene 1 (Silurana tropicalis) 235 92.00% Down syndrome critical region gene 1‐like 1 Xenopus tropicalis (Western clawed frog) DSCR1 ARP38457_P050 Q5M8Z3_XENTR (Hypothetical LOC496648) (Silurana tropicalis) 243 78.00% Xenopus tropicalis (Western clawed frog) DSCR1 ARP38457_P050 A6H8H9_XENTR Rcan3 protein (Silurana tropicalis) 235 78.00% Ordered Locus Names:AHA_2599OrganismAeromonas hydrophila subsp. hydrophila (strain ATCC 7966 / NCIB 9240) ARP54766_P050 Q66L22_XENLA MGC85233 protein Xenopus laevis (African clawed frog) 126 100.00% Ordered Locus Names:AHA_2599OrganismAeromonas hydrophila subsp. hydrophila (strain Xenopus tropicalis (Western clawed frog) ATCC 7966 / NCIB 9240) ARP54766_P050 Q28FL4_XENTR Histidine triad nucleotide binding protein 1 (Silurana tropicalis) 126 100.00% Xenopus tropicalis (Western clawed frog) pex7 ARP56091_P050 Q28E40_XENTR Peroxisomal biogenesis factor 7 (Silurana tropicalis) 322 84.00% Xenopus tropicalis (Western clawed frog) pex7 ARP56091_P050 B0JZ16_XENTR Pex7 protein (Silurana tropicalis) 117 84.00%

Transcription factor AP‐2 beta (Activating Xenopus tropicalis (Western clawed frog) Tcfap2b ARP38283_P050 Q28C75_XENTR enhancer binding protein 2 beta) (Silurana tropicalis) 441 92.00% Tcfap2b ARP38283_P050 Q66J14_XENLA MGC83414 protein Xenopus laevis (African clawed frog) 440 85.00% Xenopus tropicalis (Western clawed frog) Tcfap2b ARP38283_P050 Q9PUL8_XENTR Transcription factor AP‐2 (Fragment) (Silurana tropicalis) 430 83.00% Tcfap2b ARP38283_P050 Q91867_XENLA Transcription factor Xenopus laevis (African clawed frog) 425 83.00% Tcfap2b ARP38283_P050 Q6NTV4_XENLA Tfap2a‐a protein Xenopus laevis (African clawed frog) 407 83.00% Tcfap2b ARP38283_P050 Q63ZP3_XENLA Tcfap2a protein Xenopus laevis (African clawed frog) 433 83.00%

Transcription factor AP‐2 alpha (Activating Xenopus tropicalis (Western clawed frog) Tcfap2b ARP38283_P050 Q28EF8_XENTR enhancer binding protein 2 alpha) (Silurana tropicalis) 430 83.00%

Transcription factor AP‐2 alpha (Activating Xenopus tropicalis (Western clawed frog) Tcfap2b ARP38283_P050 Q28EF6_XENTR enhancer binding protein 2 alpha) (Silurana tropicalis) 436 83.00% Xenopus tropicalis (Western clawed frog) Tcfap2b ARP38283_P050 A4IHV0_XENTR Tfap2a protein (Silurana tropicalis) 428 83.00% hoxa2a ARP38856_P050 Q9DEZ2_XENLA Hoxa2 protein (Transcription factor Hoxa2) Xenopus laevis (African clawed frog) 369 100.00% hoxa2a ARP38856_P050 Q9DEZ1_XENLA Transcription factor Hoxa2b Xenopus laevis (African clawed frog) 375 100.00%

ORF Names:v1g166872OrganismNematostel la vectensis (Starlet sea anemone) ARP54598_P050 Q7ZXT6_XENLA MGC53624 protein Xenopus laevis (African clawed frog) 175 100.00% ORF Names:v1g166872OrganismNematostel Xenopus tropicalis (Western clawed frog) la vectensis (Starlet sea anemone) ARP54598_P050 Q6P1V0_XENTR ADP‐ribosylation factor 6 (Silurana tropicalis) 175 100.00%

ORF Names:v1g166872OrganismNematostel Xenopus tropicalis (Western clawed frog) la vectensis (Starlet sea anemone) ARP54598_P050 Q6DFR9_XENTR ADP‐ribosylation factor 6 (Silurana tropicalis) 175 100.00%

ORF Names:v1g166872OrganismNematostel la vectensis (Starlet sea anemone) ARP54598_P050 Q6DE46_XENLA ADP ribosylation factor 6 (MGC80156 protein) Xenopus laevis (African clawed frog) 175 100.00%

ORF Names:v1g166872OrganismNematostel la vectensis (Starlet sea anemone) ARP54598_P050 Q5EAX8_XENLA Arf6 protein Xenopus laevis (African clawed frog) 175 100.00%

ORF Names:v1g166872OrganismNematostel Novel protein similar to ADP‐ribosylation Xenopus tropicalis (Western clawed frog) la vectensis (Starlet sea anemone) ARP54598_P050 Q28CB6_XENTR factor 6 arf6 (Silurana tropicalis) 229 100.00%

ORF Names:v1g166872OrganismNematostel la vectensis (Starlet sea anemone) ARP54598_P050 ARF6_XENLA ADP‐ribosylation factor 6 Xenopus laevis (African clawed frog) 175 100.00% Rspry1 ARP43389_P050 Q66KG1_XENLA MGC86306 protein Xenopus laevis (African clawed frog) 575 85.00%

Novel protein containing SPRY domain‐ containing SOCS box protein SSB‐3 (Putative Xenopus tropicalis (Western clawed frog) Rspry1 ARP43389_P050 Q28E18_XENTR uncharacterized protein LOC548695) (Silurana tropicalis) 575 85.00% HGF/SF ARP44318_P050 Q91402_9PIPI Hepatocyte growth factor Xenopus 710 78.00% ALDOC ARP48273_P050 Q9PSX0_XENLA Aldoc protein (Aldolase) Xenopus laevis (African clawed frog) 364 92.00% ALDOC ARP48273_P050 Q91384_XENLA Aldolase C Xenopus laevis (African clawed frog) 364 92.00%

Aldolase C, fructose‐bisphosphate (Putative Xenopus tropicalis (Western clawed frog) ALDOC ARP48273_P050 Q6NVQ9_XENTR uncharacterized protein MGC69434) (Silurana tropicalis) 364 92.00% ALDOC ARP48273_P050 A1L3N8_XENLA LOC100037142 protein Xenopus laevis (African clawed frog) 364 78.00% ALDOC ARP48273_P050 Q7SYU5_XENLA MGC64482 protein Xenopus laevis (African clawed frog) 279 78.00% Fructose‐bisphosphate aldolase A (EC ALDOC ARP48273_P050 Q7LZE9_XENLA 4.1.2.13) (Fragments) Xenopus laevis (African clawed frog) 83 78.00% Xenopus tropicalis (Western clawed frog) ALDOC ARP48273_P050 Q6GL64_XENTR Aldolase A, fructose‐bisphosphate (Silurana tropicalis) 364 78.00% ALDOC ARP48273_P050 Q5XGT3_XENLA MGC64482 protein Xenopus laevis (African clawed frog) 364 78.00% ALDOC ARP48273_P050 Q3KPP7_XENLA MGC64482 protein Xenopus laevis (African clawed frog) 364 78.00% ALDOC ARP48273_P050 O12975_XENLA Aldolase (MGC53030 protein) Xenopus laevis (African clawed frog) 364 78.00% SLC25A21 ARP44045_P050 Q0IHC6_XENLA MGC154454 protein Xenopus laevis (African clawed frog) 299 100.00% ppid ARP56625_P050 Q641F7_XENLA MGC81732 protein Xenopus laevis (African clawed frog) 370 85.00% Xenopus tropicalis (Western clawed frog) ppid ARP56625_P050 Q6P894_XENTR Peptidylprolyl isomerase D (Cyclophilin D) (Silurana tropicalis) 370 85.00% Xenopus tropicalis (Western clawed frog) ARP46789_P050 Q0VFQ7_XENTR Putative uncharacterized protein MGC145312 (Silurana tropicalis) 333 92.00% ORF Names:ACLA_095350 EMBL EAW08602.1OrganismAspergillus clavatus ARP40609_T100 Q7ZX30_XENLA Spx‐prov protein Xenopus laevis (African clawed frog) 377 100.00% ORF Names:ACLA_095350 EMBL EAW08602.1OrganismAspergillus Xenopus tropicalis (Western clawed frog) clavatus ARP40609_T100 Q6P872_XENTR Splicing factor 3b, subunit 4, 49kDa (Silurana tropicalis) 388 100.00% ORF Names:ACLA_095350 EMBL EAW08602.1OrganismAspergillus clavatus ARP40609_T100 Q6AZR0_XENLA MGC82420 protein Xenopus laevis (African clawed frog) 383 100.00%

Eukaryotic translation initiation factor 3 subunit G‐B (eIF3g‐B) (Eukaryotic translation initiation factor 3 RNA‐binding subunit B) (eIF‐ 3 RNA‐binding subunit B) (Eukaryotic ARP40486_T100 EI3GB_XENLA translation initiation factor 3 subunit 4‐B) Xenopus laevis (African clawed frog) 308 85.00%

Eukaryotic translation initiation factor 3 subunit G‐A (eIF3g‐A) (Eukaryotic translation initiation factor 3 RNA‐binding subunit A) (eIF‐ 3 RNA‐binding subunit A) (Eukaryotic ARP40486_T100 EI3GA_XENLA translation initiation factor 3 subunit 4‐A) Xenopus laevis (African clawed frog) 308 85.00% Eukaryotic translation initiation factor 3 subunit G (eIF3g) (Eukaryotic translation initiation factor 3 RNA‐binding subunit) (eIF‐3 RNA‐binding subunit) (Eukaryotic translation Xenopus tropicalis (Western clawed frog) ARP40486_T100 EIF3G_XENTR initiation factor 3 subunit 4) (Silurana tropicalis) 310 78.00% ARP45170_T100 CADHF_XENLA EP‐cadherin (C‐cadherin) Xenopus laevis (African clawed frog) 880 91.00% spoplb ARP50314_P050 SPOPL_XENLA Speckle‐type POZ protein‐like Xenopus laevis (African clawed frog) 392 100.00% Xenopus tropicalis (Western clawed frog) spoplb ARP50314_P050 A9UMC2_XENTR LOC100135306 protein (Silurana tropicalis) 374 92.00% Xenopus tropicalis (Western clawed frog) spoplb ARP50314_P050 SPOP_XENTR Speckle‐type POZ protein (Silurana tropicalis) 374 92.00% spoplb ARP50314_P050 SPOPB_XENLA Speckle‐type POZ protein B Xenopus laevis (African clawed frog) 374 92.00% spoplb ARP50314_P050 SPOPA_XENLA Speckle‐type POZ protein A Xenopus laevis (African clawed frog) 374 92.00% Rsu1 ARP48320_T100 Q6GND8_XENLA MGC82873 protein Xenopus laevis (African clawed frog) 277 100.00% Xenopus tropicalis (Western clawed frog) Rsu1 ARP48320_T100 Q5FWR4_XENTR Ras suppressor protein 1 (Silurana tropicalis) 277 100.00% ORF Names:PBAL39_21560 EMBL EDM38703.1OrganismPedobacter sp. Xenopus tropicalis (Western clawed frog) BAL39 ARP45709_P050 Q5XGI4_XENTR Glutamate dehydrogenase 1 (Silurana tropicalis) 540 83.00% ARP38356_T100 Q641H4_XENLA MGC81571 protein Xenopus laevis (African clawed frog) 105 100.00% LOC100135170 protein (Putative Xenopus tropicalis (Western clawed frog) ARP38356_T100 A9UL95_XENTR uncharacterized protein LOC100135170) (Silurana tropicalis) 105 100.00% ARP38356_T100 Q08AX8_XENLA LOC100158391 protein Xenopus laevis (African clawed frog) 105 100.00% Xenopus tropicalis (Western clawed frog) ARP38356_T100 Q08D08_XENTR Putative uncharacterized protein MGC147402 (Silurana tropicalis) 278 92.00% ARP38356_T100 A9ULY0_XENLA LOC100137644 protein Xenopus laevis (African clawed frog) 298 92.00% LOC100126628 protein (Putative ARP38356_T100 A8E5Z3_XENLA uncharacterized protein LOC100126628) Xenopus laevis (African clawed frog) 276 92.00% Xenopus tropicalis (Western clawed frog) SLC25A16 ARP44125_T100 B5DEC2_XENTR Putative uncharacterized protein (Silurana tropicalis) 320 76.00% Nuclear receptor subfamily 1, group H, Xenopus tropicalis (Western clawed frog) ARP45633_T100 Q0IHW4_XENTR member 2 (Silurana tropicalis) 441 78.00% ORF Names:OSTLU_34727 EMBL ABO97929.1OrganismOstreococcus Xenopus tropicalis (Western clawed frog) lucimarinus (strain CCE9901) ARP40447_T100 Q6DET8_XENTR Small nuclear ribonucleoprotein polypeptide F (Silurana tropicalis) 86 100.00% ORF Names:OSTLU_34727 EMBL ABO97929.1OrganismOstreococcus Small nuclear ribonucleoprotein F (snRNP‐F) lucimarinus (strain CCE9901) ARP40447_T100 RUXF_XENLA (Sm protein F) (Sm‐F) (SmF) Xenopus laevis (African clawed frog) 86 100.00% Fbxw2 ARP43109_P050 Q7ZYD6_XENLA Fbxw2‐prov protein Xenopus laevis (African clawed frog) 454 100.00% Xenopus tropicalis (Western clawed frog) Fbxw2 ARP43109_P050 Q5U229_XENTR F‐box and WD repeat domain containing 2 (Silurana tropicalis) 454 100.00% Xenopus tropicalis (Western clawed frog) gps1 ARP58000_P050 Q66KB1_XENTR MGC89799 protein (Silurana tropicalis) 487 92.00% gps1 ARP58000_P050 Q4QQY0_XENLA MGC115579 protein Xenopus laevis (African clawed frog) 250 92.00% COP9 signalosome complex subunit 1 gps1 ARP58000_P050 CSN1_XENLA (Signalosome subunit 1) Xenopus laevis (African clawed frog) 487 92.00% ARP40177_P050 Q7ZY50_XENLA MGC53997 protein Xenopus laevis (African clawed frog) 445 100.00% Xenopus tropicalis (Western clawed frog) ARP40177_P050 Q6P367_XENTR Tubulin, beta 2B (Silurana tropicalis) 445 100.00% Xenopus tropicalis (Western clawed frog) ARP40177_P050 Q0IIR4_XENTR Tubulin, beta 2C (Silurana tropicalis) 445 100.00% ORF Names:zgc:171765 EMBL AAI51972.1 ZFIN ZDB‐GENE‐071004‐ 34OrganismDanio rerio (Zebrafish) (Brachydanio rerio) ARP57767_P050 Q6INV1_XENLA MGC80245 protein Xenopus laevis (African clawed frog) 455 84.00% ORF Names:zgc:171765 EMBL AAI51972.1 ZFIN ZDB‐GENE‐071004‐ 34OrganismDanio rerio (Zebrafish) (Brachydanio rerio) ARP57767_P050 Q6GR26_XENLA MGC81273 protein Xenopus laevis (African clawed frog) 415 84.00% ORF Names:zgc:171765 EMBL AAI51972.1 ZFIN ZDB‐GENE‐071004‐ 34OrganismDanio rerio (Zebrafish) Ppm1b protein (Protein phosphatase 1B, Xenopus tropicalis (Western clawed frog) (Brachydanio rerio) ARP57767_P050 Q66JH6_XENTR magnesium‐dependent, beta isoform) (Silurana tropicalis) 387 84.00% ORF Names:zgc:171765 EMBL AAI51972.1 ZFIN ZDB‐GENE‐071004‐ 34OrganismDanio rerio (Zebrafish) Xenopus tropicalis (Western clawed frog) (Brachydanio rerio) ARP57767_P050 A4IHV9_XENTR Ppm1a protein (Silurana tropicalis) 383 84.00% AVARP02048_T100 Q7ZX99_XENLA Tia1 protein (Fragment) Xenopus laevis (African clawed frog) 427 85.00% Xenopus tropicalis (Western clawed frog) AVARP02048_T100 Q28BS8_XENTR OTTXETP00000006403 (Silurana tropicalis) 389 85.00% AVARP02048_T100 Q90WN1_XENLA TIAR protein (Fragment) Xenopus laevis (African clawed frog) 389 78.00%

ORF Names:OsI_00731 EMBL Serine/threonine‐protein kinase 12‐B (EC EAY72860.1OrganismOryza sativa 2.7.11.1) (Aurora kinase B‐B) subsp. indica (Rice) ARP53575_P050 AUKBB_XENLA (Serine/threonine‐protein kinase aurora‐B‐B) Xenopus laevis (African clawed frog) 368 78.00% Xenopus tropicalis (Western clawed frog) fam132a ARP44518_P050 F132A_XENTR Protein FAM132A (Silurana tropicalis) 324 100.00% Xenopus tropicalis (Western clawed frog) fam132a ARP44518_P050 B3DLI3_XENTR LOC100170495 protein (Silurana tropicalis) 634 91.00% Mitochondrial dihydrolipoamide dlat ARP41994_T100 Q8JHX7_XENLA acetyltransferase Xenopus laevis (African clawed frog) 628 92.00% dlat ARP41994_T100 Q4KLR0_XENLA LOC398314 protein (Fragment) Xenopus laevis (African clawed frog) 590 92.00% dlat ARP41994_T100 Q32NX8_XENLA LOC398314 protein (Fragment) Xenopus laevis (African clawed frog) 623 92.00% Xenopus tropicalis (Western clawed frog) dlat ARP41994_T100 B1H2L3_XENTR Putative uncharacterized protein (Silurana tropicalis) 628 92.00% dlat ARP41994_T100 A0AUS4_XENLA LOC398314 protein Xenopus laevis (African clawed frog) 628 92.00% Xenopus tropicalis (Western clawed frog) SGMS1 ARP53077_P050 Q5M7L7_XENTR LOC496853 protein (Silurana tropicalis) 365 92.00% Xenopus tropicalis (Western clawed frog) SGMS1 ARP53077_P050 Q28DN3_XENTR Novel protein (Silurana tropicalis) 365 92.00% Xenopus tropicalis (Western clawed frog) ARP37416_T100 B3DM38_XENTR LOC100170601 protein (Silurana tropicalis) 333 75.00% Gphn ARP51838_P050 Q6GQZ6_XENLA MGC83148 protein Xenopus laevis (African clawed frog) 860 100.00% Gphn ARP51838_P050 Q6DF77_XENLA Gphn protein Xenopus laevis (African clawed frog) 857 100.00% Xenopus tropicalis (Western clawed frog) Gphn ARP51838_P050 A4II88_XENTR LOC100124966 protein (Silurana tropicalis) 495 100.00% Xenopus tropicalis (Western clawed frog) PPP2R5A ARP48033_P050 Q6DIR9_XENTR PPP2R5E protein (Fragment) (Silurana tropicalis) 443 100.00% PPP2R5A ARP48033_P050 Q6DFL3_XENLA Ppp2r5e‐prov protein Xenopus laevis (African clawed frog) 476 100.00% Xenopus tropicalis (Western clawed frog) PPP2R5A ARP48033_P050 Q0IIU9_XENTR PPP2R5E protein (Silurana tropicalis) 476 100.00%

PPP2R5A ARP48033_P050 A9YWT2_XENLA Phosphatase regulatory subunit B56alpha Xenopus laevis (African clawed frog) 476 100.00% Xenopus tropicalis (Western clawed frog) PPP2R5A ARP48033_P050 A4IIE4_XENTR Ppp2r5b protein (Silurana tropicalis) 491 85.00%

PPP2R5A ARP48033_P050 Q9DF48_XENLA Protein phosphatase‐2A B'epsilon subunit Xenopus laevis (African clawed frog) 467 78.00% Protein phosphatase 2, regulatory subunit B Xenopus tropicalis (Western clawed frog) PPP2R5A ARP48033_P050 Q6P3N1_XENTR (B56), epsilon isoform (Silurana tropicalis) 462 78.00% PPP2R5A ARP48033_P050 Q5XH34_XENLA LOC495076 protein Xenopus laevis (African clawed frog) 467 78.00% MAU2 chromatid cohesion factor homolog (MAU‐2) (Cohesin loading complex subunit Xenopus tropicalis (Western clawed frog) mau2 ARP55232_P050 SCC4_XENTR SCC4 homolog) (Silurana tropicalis) 604 92.00% MAU2 chromatid cohesion factor homolog (MAU‐2) (Cohesin loading complex subunit mau2 ARP55232_P050 SCC4_XENLA SCC4 homolog) Xenopus laevis (African clawed frog) 607 92.00% gtpbp2 ARP42538_P050 A6H8J2_XENLA LOC100101330 protein Xenopus laevis (African clawed frog) 584 92.00% Xenopus tropicalis (Western clawed frog) gtpbp2 ARP42538_P050 A0JLZ2_XENTR GTP binding protein 2 (Silurana tropicalis) 584 92.00% ARP42799_P050 Q9W745_XENLA COUP transcription factor 1 Xenopus laevis (African clawed frog) 411 92.00% ARP42799_P050 Q6DCH6_XENLA Nr2f2 protein Xenopus laevis (African clawed frog) 404 92.00% Xenopus tropicalis (Western clawed frog) ARP42799_P050 A4QNF4_XENTR Nr2f1 protein (Silurana tropicalis) 410 92.00% HMOX1 ARP45222_P050 Q2VPG8_XENLA MGC132176 protein Xenopus laevis (African clawed frog) 291 92.00% HMOX1 ARP45222_P050 Q6PA67_XENLA MGC68771 protein Xenopus laevis (African clawed frog) 288 91.00% ARP50315_P050 SPOPL_XENLA Speckle‐type POZ protein‐like Xenopus laevis (African clawed frog) 392 92.00% ARP58414_P050 Q6DJH8_XENLA Actr1a‐prov protein Xenopus laevis (African clawed frog) 376 100.00% Xenopus tropicalis (Western clawed frog) ARP58414_P050 A9UMK9_XENTR Putative uncharacterized protein (Silurana tropicalis) 376 100.00%

SLC13A3 ARP41438_T100 Q6E7G8_XENLA High‐affinity Na/dicarboxylate cotransporter Xenopus laevis (African clawed frog) 602 100.00% SLC13A3 ARP41438_T100 Q6DJN7_XENLA MGC81935 protein Xenopus laevis (African clawed frog) 602 100.00% Xenopus tropicalis (Western clawed frog) SLC13A3 ARP41438_T100 Q5EBF0_XENTR MGC108337 protein (Silurana tropicalis) 357 100.00% ARP38235_P050 Q91730_XENLA DNA‐binding protein Xenopus laevis (African clawed frog) 160 100.00%

Transcription factor Sox‐11‐B (Transcription ARP38235_P050 SX11B_XENLA factor Sox‐13) (xSox‐13) (XLS13B) Xenopus laevis (African clawed frog) 374 100.00% Transcription factor Sox‐11‐A (xSox‐11) ARP38235_P050 SX11A_XENLA (XLS13A) Xenopus laevis (African clawed frog) 382 100.00% Xenopus tropicalis (Western clawed frog) ARP38235_P050 SOX11_XENTR Transcription factor Sox‐11 (Silurana tropicalis) 383 100.00% ARP40321_T100 Q6PI76_XENLA Rps14‐prov protein Xenopus laevis (African clawed frog) 151 100.00% Xenopus tropicalis (Western clawed frog) ARP40321_T100 A4IGS7_XENTR Putative uncharacterized protein LOC549476 (Silurana tropicalis) 151 100.00%

Ordered Locus Names:Dvul_2084OrganismDesulfovibri Xenopus tropicalis (Western clawed frog) o vulgaris subsp. vulgaris (strain DP4) ARP43695_P050 Q0IHR6_XENTR Dlgh4 protein (Fragment) (Silurana tropicalis) 774 78.00%

Ordered Locus Names:Dvul_2084OrganismDesulfovibri Xenopus tropicalis (Western clawed frog) o vulgaris subsp. vulgaris (strain DP4) ARP43695_P050 A9JRI4_XENTR Dlgh4 protein (Fragment) (Silurana tropicalis) 782 78.00%

Ordered Locus Names:Dvul_2084OrganismDesulfovibri Xenopus tropicalis (Western clawed frog) o vulgaris subsp. vulgaris (strain DP4) ARP43695_P050 A4IHB8_XENTR Dlgh4 protein (Fragment) (Silurana tropicalis) 776 78.00%

Ordered Locus Names:Dvul_2084OrganismDesulfovibri o vulgaris subsp. vulgaris (strain DP4) ARP43695_P050 Q4KLW9_XENLA LOC443569 protein Xenopus laevis (African clawed frog) 675 76.00% DLX4 ARP34508_P050 Q6DKA7_XENLA LOC443711 protein (Fragment) Xenopus laevis (African clawed frog) 246 92.00% DLX4 ARP34508_P050 Q52L43_XENLA LOC443711 protein (Fragment) Xenopus laevis (African clawed frog) 231 92.00% DLX4 ARP34508_P050 Q4QR07_XENLA LOC780743 protein (Fragment) Xenopus laevis (African clawed frog) 230 92.00% DLX4 ARP34508_P050 Q3KQH4_XENLA MGC130625 protein Xenopus laevis (African clawed frog) 253 92.00% DLX4 ARP34508_P050 Q0P3Q7_XENLA LOC443711 protein Xenopus laevis (African clawed frog) 260 92.00% Xenopus tropicalis (Western clawed frog) DLX4 ARP34508_P050 A0PJP5_XENTR Dlx1 protein (Silurana tropicalis) 251 92.00% DLX4 ARP34508_P050 DLL1_XENLA Homeobox protein DLL‐1 (DLL) (XDLL) Xenopus laevis (African clawed frog) 250 92.00% cyp98a3 ARP41405_P050 Q6GMB9_XENLA MGC81892 protein Xenopus laevis (African clawed frog) 387 75.00% Xenopus tropicalis (Western clawed frog) cyp98a3 ARP41405_P050 B1H3J6_XENTR LOC100145650 protein (Silurana tropicalis) 511 83.00% ARP35731_T100 Q7ZY44_XENLA Ilf2‐prov protein Xenopus laevis (African clawed frog) 388 92.00% Interleukin enhancer‐binding factor 2 Xenopus tropicalis (Western clawed frog) ARP35731_T100 ILF2_XENTR homolog (Silurana tropicalis) 388 92.00% Xenopus tropicalis (Western clawed frog) LPIN1 ARP53826_P050 Q0P4S3_XENTR Lipin 1 (Silurana tropicalis) 842 85.00% Bsdc1 ARP42507_T100 BSC1A_XENLA BSD domain‐containing protein 1‐A Xenopus laevis (African clawed frog) 413 85.00% Xenopus tropicalis (Western clawed frog) Bsdc1 ARP42507_T100 BSDC1_XENTR BSD domain‐containing protein 1 (Silurana tropicalis) 412 78.00% Bsdc1 ARP42507_T100 BSC1B_XENLA BSD domain‐containing protein 1‐B Xenopus laevis (African clawed frog) 417 78.00% Xenopus tropicalis (Western clawed frog) PDE12 ARP53350_P050 Q3ZCM2_XENTR LOC734133 protein (Fragment) (Silurana tropicalis) 551 78.00% SF1 ARP38504_P050 Q7ZWT3_XENLA Sf1 protein Xenopus laevis (African clawed frog) 571 76.00% Xenopus tropicalis (Western clawed frog) SF1 ARP38504_P050 Q5M7R7_XENTR Splicing factor 1 (Silurana tropicalis) 571 76.00% Exosc2 ARP40761_P050 Q6GPU7_XENLA MGC82596 protein Xenopus laevis (African clawed frog) 293 78.00% Xenopus tropicalis (Western clawed frog) Exosc2 ARP40761_P050 Q5BJ85_XENTR Exosome component 2 (Silurana tropicalis) 293 78.00% MGC79105 protein (Seven in absentia‐like Siah1b ARP34163_T100 Q6GQJ5_XENLA protein 1 isoform a) Xenopus laevis (African clawed frog) 282 100.00% Xenopus tropicalis (Western clawed frog) Siah1b ARP34163_T100 Q5FVA4_XENTR Seven in absentia homolog 1 (Silurana tropicalis) 282 100.00% En1 P100923_P050 Q3KQ43_XENLA MGC130999 protein Xenopus laevis (African clawed frog) 229 92.00%

Homeobox protein engrailed‐1‐B (En‐1B) En1 P100923_P050 HME1B_XENLA (Homeobox protein en‐1‐B) (Fragment) Xenopus laevis (African clawed frog) 171 92.00%

ORF Names:TEgg050o24.1‐001 EMBL CAL49304.1OrganismXenopus tropicalis (Western clawed frog) (Silurana tropicalis) ARP40860_P050 Q6JPI2_XENLA Staufen Xenopus laevis (African clawed frog) 712 85.00%

ORF Names:TEgg050o24.1‐001 EMBL CAL49304.1OrganismXenopus tropicalis (Western clawed frog) (Silurana tropicalis) ARP40860_P050 Q6GM35_XENLA Stau1 protein Xenopus laevis (African clawed frog) 708 85.00%

ORF Names:TEgg050o24.1‐001 EMBL CAL49304.1OrganismXenopus tropicalis (Western clawed frog) (Silurana tropicalis) ARP40860_P050 Q5MNU4_XENLA Staufen 1 Xenopus laevis (African clawed frog) 718 85.00%

ORF Names:TEgg050o24.1‐001 EMBL CAL49304.1OrganismXenopus tropicalis (Western clawed frog) (Silurana Xenopus tropicalis (Western clawed frog) tropicalis) ARP40860_P050 Q28HT0_XENTR Novel protein similar to staufen (Silurana tropicalis) 696 85.00%

ORF Names:TEgg050o24.1‐001 EMBL CAL49304.1OrganismXenopus tropicalis (Western clawed frog) (Silurana Xenopus tropicalis (Western clawed frog) tropicalis) ARP40860_P050 Q0IHZ5_XENTR Stau1 protein (Silurana tropicalis) 686 85.00% ORF Names:TEgg050o24.1‐001 EMBL CAL49304.1OrganismXenopus tropicalis (Western clawed frog) (Silurana Xenopus tropicalis (Western clawed frog) tropicalis) ARP40860_P050 Q07G88_XENTR Novel protein similar to staufen (Fragment) (Silurana tropicalis) 351 85.00%

ORF Names:TEgg050o24.1‐001 EMBL CAL49304.1OrganismXenopus tropicalis (Western clawed frog) (Silurana tropicalis) ARP40860_P050 Q6PAB6_XENLA LOC398937 protein (Fragment) Xenopus laevis (African clawed frog) 426 85.00%

ORF Names:TEgg050o24.1‐001 EMBL CAL49304.1OrganismXenopus tropicalis (Western clawed frog) (Silurana tropicalis) ARP40860_P050 Q4KLR2_XENLA LOC398937 protein (Fragment) Xenopus laevis (African clawed frog) 380 85.00% Xenopus tropicalis (Western clawed frog) P100625_T100 B4F6M4_XENTR Putative uncharacterized protein (Silurana tropicalis) 458 85.00% P100625_T100 Q9W700_XENLA Erg protein Xenopus laevis (African clawed frog) 485 86.00% P100625_T100 Q9W6Z9_XENLA Erg protein Xenopus laevis (African clawed frog) 456 86.00% P100625_T100 Q6GNZ9_XENLA MGC80765 protein Xenopus laevis (African clawed frog) 485 86.00% P100625_T100 B7ZSD3_XENLA Erg gene (Erg_E) Xenopus laevis (African clawed frog) 456 86.00%

RPN11 ARP32450_T100 Q7ZX92_XENLA MGC80929 protein (Psmd14‐prov protein) Xenopus laevis (African clawed frog) 310 100.00% Xenopus tropicalis (Western clawed frog) RPN11 ARP32450_T100 Q5BJ72_XENTR MGC97603 protein (Silurana tropicalis) 310 100.00% CYP20A1 ARP57758_P050 Q7ZXU7_XENLA MGC52842 protein Xenopus laevis (African clawed frog) 463 92.00% Cytochrome P450, family 20, subfamily A, Xenopus tropicalis (Western clawed frog) CYP20A1 ARP57758_P050 Q28C09_XENTR polypeptide 1 (Silurana tropicalis) 463 92.00%

ORF Names:zgc:158824 ZFIN ZDB‐GENE‐ 070424‐11OrganismDanio rerio Pre‐B‐cell leukemia transcription factor 2 Xenopus tropicalis (Western clawed frog) (Zebrafish) (Brachydanio rerio) ARP38173_T100 PBX2_XENTR (Homeobox protein ) (Silurana tropicalis) 422 100.00% ORF Names:RP11‐435J19.1‐003 EMBL CAX15181.1OrganismHomo sapiens (Human) ARP41291_P050 Q6DJF2_XENLA Putative uncharacterized protein Xenopus laevis (African clawed frog) 349 78.00% ORF Names:RP11‐435J19.1‐003 EMBL CAX15181.1OrganismHomo sapiens (Human) ARP41291_P050 O42258_XENLA Wnt7B Xenopus laevis (African clawed frog) 349 78.00% ORF Names:RP11‐435J19.1‐003 EMBL CAX15181.1OrganismHomo sapiens Xenopus tropicalis (Western clawed frog) (Human) ARP41291_P050 B0JYX1_XENTR Wnt7b protein (Silurana tropicalis) 282 78.00% ORF Names:RP11‐435J19.1‐003 EMBL CAX15181.1OrganismHomo sapiens (Human) ARP41291_P050 WNT7B_XENLA Protein Wnt‐7b (XWnt‐7b) (Fragment) Xenopus laevis (African clawed frog) 135 78.00% Xenopus tropicalis (Western clawed frog) mbnl2 ARP51632_P050 A0JMA4_XENTR Putative uncharacterized protein MGC147546 (Silurana tropicalis) 312 100.00% Smith‐Magenis syndrome chromosomal Xenopus tropicalis (Western clawed frog) SMCR7L ARP49422_P050 SMC7L_XENTR region candidate gene 7 protein‐like (Silurana tropicalis) 463 100.00% LOC100101328 ARP53128_P050 A6H8J0_XENLA LOC100101328 protein (Fragment) Xenopus laevis (African clawed frog) 304 92.00% Xenopus tropicalis (Western clawed frog) LOC100101328 ARP53128_P050 CE033_XENTR UPF0465 protein C5orf33 homolog (Silurana tropicalis) 427 92.00% Xenopus tropicalis (Western clawed frog) Nmnat1 ARP48889_T100 Q28D33_XENTR Nicotinamide nucleotide adenylyltransferase 1 (Silurana tropicalis) 320 85.00% Xenopus tropicalis (Western clawed frog) ARP54888_P050 A4IHA9_XENTR LOC100125112 protein (Silurana tropicalis) 658 85.00% ARP54888_P050 Q7ZWR3_XENLA Padi2‐prov protein Xenopus laevis (African clawed frog) 660 78.00% ARP31197_P050 HXD3_XENLA Homeobox protein Hox‐D3 Xenopus laevis (African clawed frog) 413 85.00% Xenopus tropicalis (Western clawed frog) hoxd3 ARP31197_P050 Q28E82_XENTR Homeo box B3 (Homeobox B3) (Silurana tropicalis) 386 84.00% Xenopus tropicalis (Western clawed frog) hoxd3 ARP31197_P050 B2GUT3_XENTR Hoxa3 protein (Silurana tropicalis) 406 81.00% Uncharacterized glycosyltransferase AGO61 Xenopus tropicalis (Western clawed frog) C3orf39 ARP48972_T100 AGO61_XENTR (EC 2.4.‐.‐) (Silurana tropicalis) 576 85.00% C3orf39 ARP48972_T100 B7ZS08_XENLA Ago61 protein (Glycosyltransferase) Xenopus laevis (African clawed frog) 578 78.00% Uncharacterized glycosyltransferase AGO61 C3orf39 ARP48972_T100 AGO61_XENLA (EC 2.4.‐.‐) Xenopus laevis (African clawed frog) 578 78.00%

ORF Names:v1g168072OrganismNematostel la vectensis (Starlet sea anemone) ARP40614_P050 Q5HZR0_XENLA LOC496329 protein Xenopus laevis (African clawed frog) 223 85.00%

ORF Names:v1g168072OrganismNematostel Pre‐mRNA‐splicing factor SPF27 (Protein Xenopus tropicalis (Western clawed frog) la vectensis (Starlet sea anemone) ARP40614_P050 SPF27_XENTR BCAS2 homolog) (Silurana tropicalis) 223 85.00% Xenopus tropicalis (Western clawed frog) 2310028O11Rik ARP44801_P050 A9JSD9_XENTR LOC100135143 protein (Silurana tropicalis) 76 91.00% 2310028O11Rik ARP44801_P050 A4FVF7_XENLA LOC100049137 protein Xenopus laevis (African clawed frog) 76 91.00% 2310028O11Rik ARP44801_P050 Q4V7L6_XENLA MGC115578 protein Xenopus laevis (African clawed frog) 76 91.00% LOC100037142 ARP48130_T100 Q7SYU5_XENLA MGC64482 protein Xenopus laevis (African clawed frog) 279 92.00% Fructose‐bisphosphate aldolase A (EC LOC100037142 ARP48130_T100 Q7LZE9_XENLA 4.1.2.13) (Fragments) Xenopus laevis (African clawed frog) 83 92.00% Xenopus tropicalis (Western clawed frog) LOC100037142 ARP48130_T100 Q6GL64_XENTR Aldolase A, fructose‐bisphosphate (Silurana tropicalis) 364 92.00% LOC100037142 ARP48130_T100 Q5XGT3_XENLA MGC64482 protein Xenopus laevis (African clawed frog) 364 92.00% LOC100037142 ARP48130_T100 Q3KPP7_XENLA MGC64482 protein Xenopus laevis (African clawed frog) 364 92.00% LOC100037142 ARP48130_T100 O12975_XENLA Aldolase (MGC53030 protein) Xenopus laevis (African clawed frog) 364 92.00% LOC100037142 ARP48130_T100 A1L3N8_XENLA LOC100037142 protein Xenopus laevis (African clawed frog) 364 85.00% LOC100037142 ARP48130_T100 Q9PSX0_XENLA Aldoc protein (Aldolase) Xenopus laevis (African clawed frog) 364 83.00% LOC100037142 ARP48130_T100 Q91384_XENLA Aldolase C Xenopus laevis (African clawed frog) 364 83.00%

Aldolase C, fructose‐bisphosphate (Putative Xenopus tropicalis (Western clawed frog) LOC100037142 ARP48130_T100 Q6NVQ9_XENTR uncharacterized protein MGC69434) (Silurana tropicalis) 364 83.00% ZNF384 ARP31601_P050 Q6NS14_XENLA MGC78849 protein Xenopus laevis (African clawed frog) 435 78.00% Xenopus tropicalis (Western clawed frog) ZNF384 ARP31601_P050 Q6DIV1_XENTR Zinc finger protein 384 (Silurana tropicalis) 433 78.00% ZNF384 ARP31601_P050 Q6DE74_XENLA MGC78849 protein Xenopus laevis (African clawed frog) 444 78.00% Xenopus tropicalis (Western clawed frog) ZNF384 ARP31601_P050 Q28EG2_XENTR Novel protein (Silurana tropicalis) 442 78.00%

ORF Names:TRIADDRAFT_51007 EMBL EDV20481.1OrganismTrichoplax adhaerens (Trichoplax reptans) ARP40828_P050 Q6PF68_XENLA MGC68842 protein Xenopus laevis (African clawed frog) 125 100.00%

ORF Names:TRIADDRAFT_51007 EMBL EDV20481.1OrganismTrichoplax Putative uncharacterized protein LOC550003 Xenopus tropicalis (Western clawed frog) adhaerens (Trichoplax reptans) ARP40828_P050 Q28J16_XENTR (Splicing factor 3B, 14 kDa subunit (Sf3b14)) (Silurana tropicalis) 125 100.00% ORF Names:PICST_38006 EMBL EAZ63552.2OrganismPichia stipitis (Yeast) ARP40935_T100 Q5PQ94_XENLA LOC495942 protein Xenopus laevis (African clawed frog) 249 100.00% ORF Names:PICST_38006 EMBL EAZ63552.2OrganismPichia stipitis Xenopus tropicalis (Western clawed frog) (Yeast) ARP40935_T100 Q28H58_XENTR Exosome component 4 (LOC549190 protein) (Silurana tropicalis) 249 100.00% Xenopus tropicalis (Western clawed frog) fgf12 ARP55412_P050 B7U3Y0_XENTR FGF12 (Silurana tropicalis) 243 91.00% Xenopus tropicalis (Western clawed frog) fgf12 ARP55412_P050 A4IIV2_XENTR Fgf12 protein (Silurana tropicalis) 207 91.00% fgf12 ARP55412_P050 Q6GLX1_XENLA MGC84150 protein Xenopus laevis (African clawed frog) 157 83.00% ARP40705_P050 Q6INR3_XENLA HRB2 protein Xenopus laevis (African clawed frog) 372 85.00% Xenopus tropicalis (Western clawed frog) ARP40705_P050 Q0IIT5_XENTR LOC779544 protein (Fragment) (Silurana tropicalis) 371 85.00% Xenopus tropicalis (Western clawed frog) ARP40705_P050 B2RZD8_XENTR LOC779544 protein (Fragment) (Silurana tropicalis) 353 85.00% Xenopus tropicalis (Western clawed frog) ARP40705_P050 A8WGU9_XENTR LOC779544 protein (Fragment) (Silurana tropicalis) 373 85.00% ARP45318_P050 Q8AVD8_XENLA Ndufb5‐prov protein Xenopus laevis (African clawed frog) 186 92.00% Xenopus tropicalis (Western clawed frog) ARP45318_P050 A7MC41_XENTR Putative uncharacterized protein LOC550057 (Silurana tropicalis) 186 92.00% Calcium‐binding mitochondrial carrier protein SCaMC‐2 (Small calcium‐binding mitochondrial carrier protein 2) (Solute carrier Xenopus tropicalis (Western clawed frog) Slc25a25 ARP43761_P050 SCMC2_XENTR family 25 member 25) (Silurana tropicalis) 513 92.00% Calcium‐binding mitochondrial carrier protein SCaMC‐2 (Small calcium‐binding mitochondrial carrier protein 2) (Solute carrier Slc25a25 ARP43761_P050 SCMC2_XENLA family 25 member 25) Xenopus laevis (African clawed frog) 514 84.00% Xenopus tropicalis (Western clawed frog) Slc25a25 ARP43761_P050 B5DE17_XENTR Putative uncharacterized protein (Silurana tropicalis) 467 84.00% tmco1 ARP49429_P050 Q4FZN9_XENLA MGC116509 protein Xenopus laevis (African clawed frog) 188 85.00% Transmembrane and coiled‐coil domains Xenopus tropicalis (Western clawed frog) tmco1 ARP49429_P050 Q28E77_XENTR 4;xenogeneic cross‐immune protein (Silurana tropicalis) 188 85.00% GSTZ1 ARP49036_T100 Q5M986_XENLA LOC496168 protein (Fragment) Xenopus laevis (African clawed frog) 214 83.00% GSTZ1 ARP49036_T100 Q3B8M0_XENLA LOC496168 protein Xenopus laevis (African clawed frog) 216 83.00% UBE3A ARP42950_P050 Q7ZTL9_XENLA Ube3a‐prov protein Xenopus laevis (African clawed frog) 908 92.00% Ubiquitin protein ligase E3A (Human papilloma virus E6‐associated protein, Xenopus tropicalis (Western clawed frog) UBE3A ARP42950_P050 Q6NVK6_XENTR Angelman syndrome) (Silurana tropicalis) 856 92.00% pcdhac2 ARP49341_P050 Q6GLU2_XENLA MGC84237 protein Xenopus laevis (African clawed frog) 997 83.00% Xenopus tropicalis (Western clawed frog) pcdhac2 ARP49341_P050 A8KBB7_XENTR Pcdhac2 protein (Fragment) (Silurana tropicalis) 967 83.00% Xenopus tropicalis (Western clawed frog) pcdhac2 ARP49341_P050 A4IIM4_XENTR Pcdhac2 protein (Fragment) (Silurana tropicalis) 967 83.00% UDP‐glucuronic acid decarboxylase 1 (EC 4.1.1.35) (UDP‐glucuronate decarboxylase 1) Xenopus tropicalis (Western clawed frog) ARP49921_P050 UXS1_XENTR (UXS‐1) (Silurana tropicalis) 421 100.00% ARP50793_P050 Q3KPT4_XENLA MGC131338 protein Xenopus laevis (African clawed frog) 262 92.00% Xenopus tropicalis (Western clawed frog) ARP50793_P050 A9ULH3_XENTR Putative uncharacterized protein (Silurana tropicalis) 190 92.00% Xenopus tropicalis (Western clawed frog) sult2st2 ARP49134_P050 Q6P8G4_XENTR Putative uncharacterized protein MGC75696 (Silurana tropicalis) 287 92.00% Xenopus tropicalis (Western clawed frog) sult2st2 ARP49134_P050 A4IH93_XENTR LOC100124815 protein (Silurana tropicalis) 308 92.00% sult2st2 ARP49134_P050 Q68EV4_XENLA MGC84291 protein Xenopus laevis (African clawed frog) 276 92.00% sult2st2 ARP49134_P050 A5D8P4_XENLA LOC100049765 protein Xenopus laevis (African clawed frog) 308 85.00% sult2st2 ARP49134_P050 Q6GP49_XENLA MGC80677 protein Xenopus laevis (African clawed frog) 297 85.00% sult2st2 ARP49134_P050 B7ZSE1_XENLA LOC100126626 protein Xenopus laevis (African clawed frog) 304 85.00% sult2st2 ARP49134_P050 B7ZSE0_XENLA LOC100126626 protein Xenopus laevis (African clawed frog) 304 85.00% sult2st2 ARP49134_P050 A8E5Z0_XENLA LOC100126626 protein Xenopus laevis (African clawed frog) 304 85.00% Sulfotransferase family, cytosolic, 1A, phenol‐ Xenopus tropicalis (Western clawed frog) sult2st2 ARP49134_P050 Q5HZV7_XENTR preferring, member 1 (Silurana tropicalis) 287 78.00% sult2st2 ARP49134_P050 Q66KW4_XENLA MGC85375 protein Xenopus laevis (African clawed frog) 305 78.00% sult2st2 ARP49134_P050 Q5U5E7_XENLA LOC495289 protein Xenopus laevis (African clawed frog) 304 78.00% sult2st2 ARP49134_P050 Q7ZYH0_XENLA Sult1c1‐prov protein Xenopus laevis (African clawed frog) 304 78.00% sult2st2 ARP49134_P050 Q5BJ35_XENLA LOC733172 protein (Fragment) Xenopus laevis (African clawed frog) 310 78.00% sult2st2 ARP49134_P050 Q0IH61_XENLA LOC733172 protein Xenopus laevis (African clawed frog) 292 78.00% Xenopus tropicalis (Western clawed frog) sult2st2 ARP49134_P050 A4IH19_XENTR LOC100038305 protein (Silurana tropicalis) 292 78.00% Xenopus tropicalis (Western clawed frog) sult2st2 ARP49134_P050 Q05AZ4_XENTR LOC779590 protein (Fragment) (Silurana tropicalis) 288 78.00% Xenopus tropicalis (Western clawed frog) sult2st2 ARP49134_P050 A9JTJ7_XENTR LOC779590 protein (Silurana tropicalis) 294 78.00% ORF Names:ACLA_069350 EMBL EAW13905.1OrganismAspergillus clavatus ARP40684_P050 Q5U561_XENLA LOC495359 protein Xenopus laevis (African clawed frog) 501 100.00%

Lysine‐specific demethylase 2A (EC 1.14.11.27) (F‐box and leucine‐rich repeat protein 11) (F‐box/LRR‐repeat protein 11) ORF Names:ACLA_069350 EMBL (JmjC domain‐containing histone EAW13905.1OrganismAspergillus demethylation protein 1A) ([Histone‐H3]‐ Xenopus tropicalis (Western clawed frog) clavatus ARP40684_P050 KDM2A_XENTR lysine‐36 demethylase 1A) (Silurana tropicalis) 1146 100.00% hcfc1a ARP38600_T100 Q640G9_XENLA LOC494675 protein Xenopus laevis (African clawed frog) 2101 100.00%

Mediator of RNA polymerase II transcription Xenopus tropicalis (Western clawed frog) PTOV1 ARP50614_P050 MED25_XENTR subunit 25 (Mediator complex subunit 25) (Silurana tropicalis) 805 78.00% Xenopus tropicalis (Western clawed frog) pfn1 ARP48269_P050 B3DLX0_XENTR LOC100170559 protein (Silurana tropicalis) 138 84.00% ORF Names:PANDA_011596 EMBL EFB16496.1OrganismAiluropoda melanoleuca (Giant panda) ARP48316_P050 Q6DKA8_XENLA MGC84728 protein Xenopus laevis (African clawed frog) 301 76.00% ORF Names:PANDA_011596 EMBL EFB16496.1OrganismAiluropoda melanoleuca (Giant panda) ARP48316_P050 Q6DEB3_XENLA MGC79025 protein Xenopus laevis (African clawed frog) 301 76.00% ORF Names:PANDA_011596 EMBL EFB16496.1OrganismAiluropoda Xenopus tropicalis (Western clawed frog) melanoleuca (Giant panda) ARP48316_P050 PHB2_XENTR Prohibitin‐2 (Silurana tropicalis) 301 76.00%

WNT2B ARP41254_T100 WN2BB_XENLA Protein Wnt‐2b‐B (Protein Xwnt‐2) (Fragment) Xenopus laevis (African clawed frog) 128 92.00% Xenopus tropicalis (Western clawed frog) ARP50638_P050 Q5EC53_XENTR Mitochondrial malic enzyme 2 (Silurana tropicalis) 583 85.00% Xenopus tropicalis (Western clawed frog) ARP50638_P050 B7ZUK1_XENTR Mitochondrial malic enzyme 2 (Silurana tropicalis) 583 85.00% ARP50638_P050 Q802E8_XENLA Mitochondrial malic enzyme 2 Xenopus laevis (African clawed frog) 583 91.00% ARP50638_P050 Q5XH25_XENLA Me2 protein Xenopus laevis (African clawed frog) 583 91.00% ORF Names:v1g223708OrganismNematostel la vectensis (Starlet sea anemone) ARP56661_P050 B7ZR20_XENLA Septin A Xenopus laevis (African clawed frog) 356 100.00%

ORF Names:v1g223708OrganismNematostel Xenopus tropicalis (Western clawed frog) la vectensis (Starlet sea anemone) ARP56661_P050 SEP2B_XENTR Septin‐2B (Silurana tropicalis) 355 100.00%

ORF Names:v1g223708OrganismNematostel la vectensis (Starlet sea anemone) ARP56661_P050 SEP2B_XENLA Septin‐2B Xenopus laevis (African clawed frog) 352 100.00%

ORF Names:v1g223708OrganismNematostel Xenopus tropicalis (Western clawed frog) la vectensis (Starlet sea anemone) ARP56661_P050 SEP2A_XENTR Septin‐2A (Silurana tropicalis) 350 100.00%

ORF Names:v1g223708OrganismNematostel la vectensis (Starlet sea anemone) ARP56661_P050 SEP2A_XENLA Septin‐2A (Septin‐A) (XlSeptA) Xenopus laevis (African clawed frog) 356 100.00% marR ARP41509_T100 Q7ZXR6_XENLA Prps1 protein (Fragment) Xenopus laevis (African clawed frog) 326 85.00% Similar to phosphoribosyl pyrophosphate Xenopus tropicalis (Western clawed frog) marR ARP41509_T100 Q6P830_XENTR synthetase 1 (Silurana tropicalis) 318 85.00% marR ARP41509_T100 Q6AZI9_XENLA Prps1 protein Xenopus laevis (African clawed frog) 318 85.00% Ribose‐phosphate pyrophosphokinase 2 (EC 2.7.6.1) (Phosphoribosyl pyrophosphate Xenopus tropicalis (Western clawed frog) marR ARP41509_T100 PRPS2_XENTR synthase II) (PRS‐II) (Silurana tropicalis) 318 85.00% Ribose‐phosphate pyrophosphokinase 2 (EC 2.7.6.1) (Phosphoribosyl pyrophosphate marR ARP41509_T100 PRPS2_XENLA synthase II) (PRS‐II) Xenopus laevis (African clawed frog) 318 85.00% MutL homolog 1, colon , nonpolyposis Xenopus tropicalis (Western clawed frog) mlh1 ARP56076_P050 Q28IF0_XENTR type 2 (E. coli) (Fragment) (Silurana tropicalis) 205 100.00% mlh1 ARP56076_P050 A0AUU1_XENLA LOC100036779 protein Xenopus laevis (African clawed frog) 750 100.00% Mamld1 ARP34221_T100 Q6GN59_XENLA MGC83004 protein Xenopus laevis (African clawed frog) 998 92.00%

ORF Names:GSTENG00038674001 Cytoplasmic polyadenylation element‐binding EMBL CAG14312.1OrganismTetraodon protein 3 (CPE‐BP3) (CPE‐binding protein 3) Xenopus tropicalis (Western clawed frog) nigroviridis (Green puffer) ARP55103_P050 CPEB3_XENTR (CPEB‐3) (Silurana tropicalis) 632 84.00% Xenopus tropicalis (Western clawed frog) apbb2 ARP55624_P050 B1WB60_XENTR Apbb2 protein (Silurana tropicalis) 757 86.00% ORF Names:OsI_37065 EMBL EAY81899.1OrganismOryza sativa subsp. indica (Rice) ARP55382_P050 Q6AZH8_XENLA Putative uncharacterized protein Xenopus laevis (African clawed frog) 652 78.00% ORF Names:OsI_37065 EMBL EAY81899.1OrganismOryza sativa subsp. indica (Rice) ARP55382_P050 A1L3K5_XENLA LOC100037033 protein Xenopus laevis (African clawed frog) 646 81.00% NUP155 ARP53833_P050 Q7ZWL0_XENLA Nup155‐prov protein Xenopus laevis (African clawed frog) 1388 84.00% CPE ARP58445_P050 B1WBB5_XENLA LOC100158417 protein Xenopus laevis (African clawed frog) 463 86.00% CPE ARP58445_P050 Q08B06_XENLA LOC100158368 protein Xenopus laevis (African clawed frog) 464 100.00% Xenopus tropicalis (Western clawed frog) CPE ARP58445_P050 A8E4W2_XENTR LOC100127580 protein (Silurana tropicalis) 462 90.00% Oxct1 ARP48480_P050 Q7ZYR2_XENLA MGC69180 protein (Fragment) Xenopus laevis (African clawed frog) 529 92.00% Oxct1 ARP48480_P050 Q6PCE5_XENLA MGC69180 protein Xenopus laevis (African clawed frog) 530 92.00% Xenopus tropicalis (Western clawed frog) Oxct1 ARP48480_P050 Q66KJ2_XENTR Oxct1 protein (Silurana tropicalis) 530 92.00% Sjogren syndrome antigen A2 (60kDa, trove2 ARP40534_T100 B7ZQ38_XENLA ribonucleoprotein autoantigen SS‐A/Ro) Xenopus laevis (African clawed frog) 538 78.00%

60 kDa SS‐A/Ro ribonucleoprotein (60 kDa Ro protein) (60 kDa ribonucleoprotein Ro) trove2 ARP40534_T100 RO60_XENLA (RoRNP) (TROVE domain family member 2) Xenopus laevis (African clawed frog) 538 78.00% Xenopus tropicalis (Western clawed frog) xyl1 ARP42553_T100 Q5XGB0_XENTR Aldo‐keto reductase family 1, member B7 (Silurana tropicalis) 318 90.00%

ORF Names:BRAFLDRAFT_123482 UDP‐GalNAc:beta‐1,3‐N‐ EMBL acetylgalactosaminyltransferase 2 (Beta‐1,3‐ EEN46142.1OrganismBranchiostoma GalNAc‐T2) (EC 2.4.1.‐) (Beta‐1,3‐N‐ Xenopus tropicalis (Western clawed frog) floridae (Florida lancelet) (Amphioxus) ARP49061_P050 B3GL2_XENTR acetylgalactosaminyltransferase II) (Silurana tropicalis) 488 92.00%

ORF Names:BRAFLDRAFT_123482 UDP‐GalNAc:beta‐1,3‐N‐ EMBL acetylgalactosaminyltransferase 2 (Beta‐1,3‐ EEN46142.1OrganismBranchiostoma GalNAc‐T2) (EC 2.4.1.‐) (Beta‐1,3‐N‐ floridae (Florida lancelet) (Amphioxus) ARP49061_P050 B3GL2_XENLA acetylgalactosaminyltransferase II) Xenopus laevis (African clawed frog) 486 92.00% PLS1 ARP56400_P050 Q6P7I8_XENLA MGC68681 protein Xenopus laevis (African clawed frog) 629 85.00% Xenopus tropicalis (Western clawed frog) PLS1 ARP56400_P050 Q504Q2_XENTR Plastin 3 (T isoform) (Silurana tropicalis) 629 85.00% Xenopus tropicalis (Western clawed frog) PLS1 ARP56400_P050 B3DLB0_XENTR LOC100170476 protein (Silurana tropicalis) 624 84.00% PRMT5 ARP40185_T100 Q6NUA1_XENLA Hsl7 protein (Methyltransferase Hsl7) Xenopus laevis (African clawed frog) 633 92.00% PRMT5 ARP40185_T100 Q5U491_XENLA LOC495515 protein (Fragment) Xenopus laevis (African clawed frog) 631 92.00% PRMT5 ARP40185_T100 Q2VPH9_XENLA LOC495515 protein Xenopus laevis (African clawed frog) 633 92.00% Xenopus tropicalis (Western clawed frog) PRMT5 ARP40185_T100 B1WBI5_XENTR Prmt5 protein (Fragment) (Silurana tropicalis) 629 92.00% MYH11 ARP42270_P050 Q04834_XENLA Nonmuscle myosin heavy chain b Xenopus laevis (African clawed frog) 1992 92.00% Xenopus tropicalis (Western clawed frog) MYH11 ARP42270_P050 B2GU83_XENTR LOC100158525 protein (Fragment) (Silurana tropicalis) 1601 92.00% MYH11 ARP42270_P050 Q801T0_XENLA LOC398083 protein (Fragment) Xenopus laevis (African clawed frog) 1250 92.00% MYH11 ARP42270_P050 Q6PA34_XENLA LOC398083 protein (Fragment) Xenopus laevis (African clawed frog) 941 92.00%

MYH11 ARP42270_P050 Q6AX95_XENLA Putative uncharacterized protein (Fragment) Xenopus laevis (African clawed frog) 946 92.00% MYH11 ARP42270_P050 O93522_XENLA Nonmuscle myosin II heavy chain A Xenopus laevis (African clawed frog) 1964 92.00% MYH11 ARP42270_P050 B7ZS76_XENLA LOC398083 protein Xenopus laevis (African clawed frog) 1962 92.00% MYH11 ARP42270_P050 Q6PF49_XENLA LOC398719 protein (Fragment) Xenopus laevis (African clawed frog) 941 85.00% MYH11 ARP42270_P050 Q6GQA2_XENLA LOC443585 protein (Fragment) Xenopus laevis (African clawed frog) 1388 78.00% MYH11 ARP42270_P050 Q5XG19_XENLA LOC495286 protein (Fragment) Xenopus laevis (African clawed frog) 605 78.00% MYH11 ARP42270_P050 B1H1V0_XENLA LOC495286 protein (Fragment) Xenopus laevis (African clawed frog) 1047 78.00%

KLRAQ motif‐containing protein 1 (Coiled‐coil KLRAQ1 ARP53125_P050 KLRAQ_XENLA domain‐containing protein 128) Xenopus laevis (African clawed frog) 776 100.00% ARP55432_P050 Q7ZXE8_XENLA Ehd4 protein Xenopus laevis (African clawed frog) 537 76.00% hemH ARP41682_T100 Q3B8H9_XENLA LOC398014 protein Xenopus laevis (African clawed frog) 418 85.00%

Ferrochelatase, mitochondrial (EC 4.99.1.1) hemH ARP41682_T100 HEMH_XENLA (Heme synthase) (Protoheme ferro‐lyase) Xenopus laevis (African clawed frog) 411 85.00% Glycosyltransferase‐like domain‐containing Xenopus tropicalis (Western clawed frog) Gtdc1 ARP48906_P050 GTDC1_XENTR protein 1 (Silurana tropicalis) 437 100.00% Glycosyltransferase‐like domain‐containing Gtdc1 ARP48906_P050 GTDC1_XENLA protein 1 Xenopus laevis (African clawed frog) 437 100.00% Xenopus tropicalis (Western clawed frog) SF3A1 ARP40615_P050 B1H374_XENTR LOC100145564 protein (Fragment) (Silurana tropicalis) 255 100.00% SF3A1 ARP40615_P050 Q6GPA9_XENLA MGC80562 protein Xenopus laevis (African clawed frog) 802 85.00% Ldb4 ARP37730_P050 A9UM32_XENLA LIM domain binding protein 1 Xenopus laevis (African clawed frog) 375 100.00% Xenopus tropicalis (Western clawed frog) Ldb4 ARP37730_P050 LDB1_XENTR LIM domain‐binding protein 1 (LDB‐1) (Silurana tropicalis) 373 100.00%

Ldb4 ARP37730_P050 LDB1_XENLA LIM domain‐binding protein 1 (LDB‐1) (xLdb1) Xenopus laevis (African clawed frog) 375 100.00% Xenopus tropicalis (Western clawed frog) zbtb6 ARP38836_P050 A4IGN9_XENTR Zbtb6 protein (Silurana tropicalis) 415 84.00% Ptp4a2 ARP51193_P050 Q6L7J1_XENLA XPRL‐3 Xenopus laevis (African clawed frog) 173 100.00% Ptp4a2 ARP51193_P050 Q3KPU9_XENLA MGC131305 protein Xenopus laevis (African clawed frog) 108 100.00% Xenopus tropicalis (Western clawed frog) Ptp4a2 ARP51193_P050 B3DLA8_XENTR Putative uncharacterized protein (Silurana tropicalis) 173 100.00% Xenopus tropicalis (Western clawed frog) Ptp4a2 ARP51193_P050 B1H2D2_XENTR LOC100145393 protein (Silurana tropicalis) 173 100.00% Ptp4a2 ARP51193_P050 Q7ZXL1_XENLA Ptp4a2 protein (XPRL‐2) Xenopus laevis (African clawed frog) 167 92.00% Ptp4a2 ARP51193_P050 Q6L7J3_XENLA XPRL‐1 Xenopus laevis (African clawed frog) 173 92.00% Ptp4a2 ARP51193_P050 Q6GQG4_XENLA MGC80084 protein Xenopus laevis (African clawed frog) 167 92.00% Ptp4a2 ARP51193_P050 Q6AZN3_XENLA Ptp4a1‐prov protein Xenopus laevis (African clawed frog) 173 92.00% Protein tyrosine phosphatase type IVA, Xenopus tropicalis (Western clawed frog) Ptp4a2 ARP51193_P050 Q66JI4_XENTR member 1 (Silurana tropicalis) 173 92.00% Protein tyrosine phosphatase type IVA, Xenopus tropicalis (Western clawed frog) Ptp4a2 ARP51193_P050 Q28IC6_XENTR member 2 (Silurana tropicalis) 167 92.00% Ptp4a2 ARP51193_P050 Q08B48_XENLA Prl‐1 protein (Fragment) Xenopus laevis (African clawed frog) 196 92.00% Ptp4a2 ARP51193_P050 B7ZQM0_XENLA XPRL‐1 Xenopus laevis (African clawed frog) 173 92.00% MGC97619 protein ( associated antigen Xenopus tropicalis (Western clawed frog) SPAG6 ARP53681_P050 Q5EB40_XENTR 6) (Silurana tropicalis) 508 100.00% SPAG6 ARP53681_P050 Q3KQ89_XENLA MGC130870 protein Xenopus laevis (African clawed frog) 508 100.00% rrm1 ARP46029_T100 Q6GM88_XENLA RRM1 protein Xenopus laevis (African clawed frog) 797 92.00% Xenopus tropicalis (Western clawed frog) rrm1 ARP46029_T100 B1WAW9_XENTR LOC100145720 protein (Silurana tropicalis) 797 92.00%

DKEY‐85K8.2 ARP40240_T100 Q9W6R9_XENLA RNA‐binding protein XlhnRNPL (Fragment) Xenopus laevis (African clawed frog) 273 84.00% DKEY‐85K8.2 ARP40240_T100 Q6DDP7_XENLA Putative uncharacterized protein Xenopus laevis (African clawed frog) 538 76.00% Xenopus tropicalis (Western clawed frog) DKEY‐85K8.2 ARP40240_T100 A4QNC9_XENTR Hnrpl protein (Silurana tropicalis) 538 76.00% PFKL ARP45774_T100 Q6PF67_XENLA MGC68847 protein Xenopus laevis (African clawed frog) 784 85.00% Xenopus tropicalis (Western clawed frog) PFKL ARP45774_T100 Q6P4Y8_XENTR Phosphofructokinase, platelet (Silurana tropicalis) 802 85.00% PFKL ARP45774_T100 Q6DD69_XENLA MGC79063 protein Xenopus laevis (African clawed frog) 808 85.00% Xenopus tropicalis (Western clawed frog) PFKL ARP45774_T100 B5DET9_XENTR Putative uncharacterized protein (Fragment) (Silurana tropicalis) 792 85.00% PFKL ARP45774_T100 A2RV78_XENLA LOC100037146 protein Xenopus laevis (African clawed frog) 786 85.00% ORF Names:GSPATT00020371001 EMBL CAK86699.1OrganismParamecium tetraurelia ARP40626_T100 Q8AVP8_XENLA Cyp‐7‐prov protein Xenopus laevis (African clawed frog) 164 100.00% ORF Names:GSPATT00020371001 EMBL CAK86699.1OrganismParamecium tetraurelia ARP40626_T100 Q7SZ12_XENLA CypA protein (Fragment) Xenopus laevis (African clawed frog) 193 100.00% ORF Names:GSPATT00020371001 EMBL CAK86699.1OrganismParamecium Peptidylprolyl cis‐trans isomerase (EC 5.2.1.8) tetraurelia ARP40626_T100 Q70YG6_XENLA (Fragment) Xenopus laevis (African clawed frog) 157 100.00% ORF Names:GSPATT00020371001 EMBL CAK86699.1OrganismParamecium Xenopus tropicalis (Western clawed frog) tetraurelia ARP40626_T100 Q6PBF3_XENTR Putative uncharacterized protein MGC75715 (Silurana tropicalis) 164 100.00% ORF Names:GSPATT00020371001 EMBL CAK86699.1OrganismParamecium tetraurelia ARP40626_T100 Q6NUH4_XENLA CypA protein (Fragment) Xenopus laevis (African clawed frog) 192 100.00% ORF Names:GSPATT00020371001 EMBL CAK86699.1OrganismParamecium tetraurelia ARP40626_T100 Q6DTN6_XENLA Cyclophilin A (CypA protein) Xenopus laevis (African clawed frog) 164 100.00% ORF Names:GSPATT00020371001 EMBL CAK86699.1OrganismParamecium Xenopus tropicalis (Western clawed frog) tetraurelia ARP40626_T100 Q66JH4_XENTR MGC79544 protein (Silurana tropicalis) 105 100.00% ORF Names:GSPATT00020371001 EMBL CAK86699.1OrganismParamecium tetraurelia ARP40626_T100 A8E5Z6_XENLA LOC100126631 protein (Fragment) Xenopus laevis (African clawed frog) 197 100.00% ORF Names:GSPATT00020371001 EMBL CAK86699.1OrganismParamecium tetraurelia ARP40626_T100 Q0IH13_XENLA MGC154898 protein Xenopus laevis (African clawed frog) 294 92.00% Xenopus tropicalis (Western clawed frog) ST3GAL1 ARP45410_P050 D2U4U0_XENTR Alpha‐2,3‐sialyltransferase ST3Gal I (Silurana tropicalis) 334 83.00%

ORF Names:v1g79346OrganismNematostell a vectensis (Starlet sea anemone) ARP52067_P050 Q8UWC3_XENLA Cortactin Xenopus laevis (African clawed frog) 530 92.00%

ORF Names:v1g79346OrganismNematostell a vectensis (Starlet sea anemone) ARP52067_P050 Q6GNQ0_XENLA MGC80961 protein Xenopus laevis (African clawed frog) 560 92.00%

ORF Names:v1g79346OrganismNematostell a vectensis (Starlet sea anemone) ARP52067_P050 B7ZQN6_XENLA Cttn protein Xenopus laevis (African clawed frog) 530 92.00%

ORF Names:v1g79346OrganismNematostell Xenopus tropicalis (Western clawed frog) a vectensis (Starlet sea anemone) ARP52067_P050 B3DLZ9_XENTR Cttn protein (Silurana tropicalis) 535 92.00% lfng ARP48573_P050 B7ZQE6_XENLA Lunatic fringe Xenopus laevis (African clawed frog) 375 84.00% lfng ARP48573_P050 A1L2S5_XENLA LOC100036937 protein Xenopus laevis (African clawed frog) 373 84.00% Beta‐1,3‐N‐acetylglucosaminyltransferase lunatic fringe (EC 2.4.1.222) (O‐fucosylpeptide lfng ARP48573_P050 LFNG_XENLA 3‐beta‐N‐acetylglucosaminyltransferase) Xenopus laevis (African clawed frog) 375 84.00% Protein LSM14 homolog A‐B (RNA‐associated Lsm14a ARP55288_P050 L14AB_XENLA protein 55A‐B) (RAP55A‐B) Xenopus laevis (African clawed frog) 471 78.00%

Lysine‐specific demethylase 8 (EC 1.14.11.27) (JmjC domain‐containing protein 5) (Jumonji Xenopus tropicalis (Western clawed frog) jmjd5 ARP58120_P050 KDM8_XENTR domain‐containing protein 5) (Silurana tropicalis) 443 92.00% Xenopus tropicalis (Western clawed frog) cbll1 ARP33601_P050 B3DL63_XENTR LOC100170461 protein (Silurana tropicalis) 500 85.00%

E3 ubiquitin‐protein ligase Hakai (EC 6.3.2.‐) (Casitas B‐lineage lymphoma‐transforming cbll1 ARP33601_P050 HAKAI_XENLA sequence‐like protein 1) (c‐Cbl‐like protein 1) Xenopus laevis (African clawed frog) 496 85.00% cbll1 ARP33601_P050 A5PKQ1_XENLA LOC100101300 protein Xenopus laevis (African clawed frog) 503 78.00% aplp2 ARP33074_P050 Q98SG0_XENLA Beta‐amyloid protein A Xenopus laevis (African clawed frog) 693 100.00% aplp2 ARP33074_P050 Q98SF9_XENLA Beta‐amyloid protein B Xenopus laevis (African clawed frog) 695 100.00% aplp2 ARP33074_P050 Q91963_9PIPI APP747 Xenopus 747 100.00% aplp2 ARP33074_P050 Q7ZXQ0_XENLA MGC52816 protein Xenopus laevis (African clawed frog) 695 100.00% aplp2 ARP33074_P050 Q6NRR1_XENLA App protein Xenopus laevis (African clawed frog) 749 100.00% Xenopus tropicalis (Western clawed frog) aplp2 ARP33074_P050 Q6DJB6_XENTR Amyloid beta (A4) protein (Silurana tropicalis) 750 100.00% Prpf6 ARP40734_T100 Q6AXA7_XENLA MGC80263 protein Xenopus laevis (African clawed frog) 948 92.00% Xenopus tropicalis (Western clawed frog) Prpf6 ARP40734_T100 Q5BJ59_XENTR MGC97740 protein (Silurana tropicalis) 972 92.00% Transcription factor Sox‐2 (SRY (sex Xenopus tropicalis (Western clawed frog) Sox2 ARP38233_P050 SOX2_XENTR determining region Y)‐box 2) (Silurana tropicalis) 311 78.00% NELL2 ARP46700_T100 Q6IR63_XENLA LOC432073 protein (Fragment) Xenopus laevis (African clawed frog) 737 78.00% NELL2 ARP46700_T100 Q6DJD9_XENLA LOC443728 protein (Fragment) Xenopus laevis (African clawed frog) 780 78.00% Xenopus tropicalis (Western clawed frog) NELL2 ARP46700_T100 Q0V9M7_XENTR Nell1 protein (Fragment) (Silurana tropicalis) 828 78.00% Chromatin modification‐related protein MEAF6 (MYST/Esa1‐associated factor 6) (Esa1‐ associated factor 6 homolog) (Protein EAF6 Xenopus tropicalis (Western clawed frog) DKEY‐218F9.2 ARP33354_P050 EAF6_XENTR homolog) (Silurana tropicalis) 191 100.00% Chromatin modification‐related protein MEAF6 (MYST/Esa1‐associated factor 6) (Esa1‐ associated factor 6 homolog) (Protein EAF6 DKEY‐218F9.2 ARP33354_P050 EAF6_XENLA homolog) Xenopus laevis (African clawed frog) 188 100.00% Ordered Locus Names:Bcen2424_6238OrganismBurkh olderia cenocepacia (strain HI2424) ARP41468_T100 Q5U5B3_XENLA LOC495311 protein Xenopus laevis (African clawed frog) 497 100.00% POLK ARP48792_P050 Q6DFE4_XENLA Polk‐prov protein Xenopus laevis (African clawed frog) 862 78.00% POLK ARP48792_P050 Q58M12_XENLA DNA polymerase kappa Xenopus laevis (African clawed frog) 862 78.00% ARP40173_P050 Q7ZWR7_XENLA MGC53823 protein Xenopus laevis (African clawed frog) 377 100.00% ARP40173_P050 Q7SYU4_XENLA MGC64484 protein Xenopus laevis (African clawed frog) 377 100.00% ARP40173_P050 Q6NS10_XENLA MGC78870 protein Xenopus laevis (African clawed frog) 377 100.00% ARP40173_P050 Q6IP22_XENLA MGC79012 protein Xenopus laevis (African clawed frog) 377 100.00% Xenopus tropicalis (Western clawed frog) ARP40173_P050 Q6DIV8_XENTR Actin, alpha 1, skeletal muscle (Silurana tropicalis) 377 100.00% Xenopus tropicalis (Western clawed frog) ARP40173_P050 Q5M8T9_XENTR Actin, alpha 2, smooth muscle, aorta (Silurana tropicalis) 377 100.00% ARP40173_P050 Q52QH5_XENLA Smooth muscle alpha actin Xenopus laevis (African clawed frog) 377 100.00% ARP40173_P050 Q32NP0_XENLA MGC131002 protein Xenopus laevis (African clawed frog) 376 100.00% Xenopus tropicalis (Western clawed frog) gpnmb ARP44500_P050 B4F6X8_XENTR Gpnmb protein (Silurana tropicalis) 587 91.00% gpnmb ARP44500_P050 Q4V805_XENLA LOC733250 protein (Fragment) Xenopus laevis (African clawed frog) 595 83.00% gpnmb ARP44500_P050 Q08B79_XENLA LOC733250 protein (Fragment) Xenopus laevis (African clawed frog) 595 83.00% gpnmb ARP44500_P050 A1L3E3_XENLA LOC733250 protein Xenopus laevis (African clawed frog) 597 83.00% ATP‐dependent RNA helicase A‐like protein (EC 3.6.4.13) (DEAH box protein 9) (Nuclear Dhx9 ARP36343_P050 DHX9_XENLA DNA helicase II) (NDH II) Xenopus laevis (African clawed frog) 1262 85.00% HMGCL ARP41686_T100 Q6INN1_XENLA MGC82338 protein Xenopus laevis (African clawed frog) 328 76.00% KIAA0020 ARP40334_P050 Q7ZY94_XENLA LOC398471 protein (Fragment) Xenopus laevis (African clawed frog) 616 100.00% KIAA0020 ARP40334_P050 Q5M7C1_XENLA LOC398471 protein Xenopus laevis (African clawed frog) 641 100.00% Xenopus tropicalis (Western clawed frog) KIAA0020 ARP40334_P050 B1H3L1_XENTR LOC100038289 protein (Silurana tropicalis) 642 90.00% Xenopus tropicalis (Western clawed frog) KIAA0020 ARP40334_P050 A4IGZ6_XENTR LOC100038289 protein (Fragment) (Silurana tropicalis) 632 90.00% pdia6 ARP52103_P050 Q7ZWN2_XENLA Pdip5‐prov protein Xenopus laevis (African clawed frog) 442 92.00% Protein disulfide isomerase family A, member Xenopus tropicalis (Western clawed frog) pdia6 ARP52103_P050 Q66KA7_XENTR 6 (Silurana tropicalis) 441 92.00% Protein disulfide isomerase family A, member Xenopus tropicalis (Western clawed frog) pdia6 ARP52103_P050 Q28HG8_XENTR 6 (Silurana tropicalis) 441 92.00% pdia6 ARP52103_P050 Q6DEA4_XENLA MGC79068 protein Xenopus laevis (African clawed frog) 442 92.00%

ORF Names:PANDA_004671 EMBL LETM1 and EF‐hand domain‐containing EFB15573.1OrganismAiluropoda protein 1, mitochondrial (Leucine zipper‐EF‐ Xenopus tropicalis (Western clawed frog) melanoleuca (Giant panda) ARP46881_T100 LETM1_XENTR hand‐containing transmembrane protein 1) (Silurana tropicalis) 760 92.00% NEDD8‐conjugating enzyme Ubc12 (EC 6.3.2.‐) (NEDD8 carrier protein) (NEDD8 protein Xenopus tropicalis (Western clawed frog) UBE2M ARP43030_P050 UBC12_XENTR ligase) (Ubiquitin‐conjugating enzyme E2 M) (Silurana tropicalis) 183 100.00%

NEDD8‐conjugating enzyme Ubc12 (EC 6.3.2.‐) (NEDD8 carrier protein) (NEDD8 protein UBE2M ARP43030_P050 UBC12_XENLA ligase) (Ubiquitin‐conjugating enzyme E2 M) Xenopus laevis (African clawed frog) 183 100.00% ORF Names:cgd6_2490 EMBL EAZ51520.1OrganismCryptosporidium Xenopus tropicalis (Western clawed frog) parvum Iowa II ARP43481_P050 A8E4U9_XENTR LOC100127570 protein (Silurana tropicalis) 753 92.00% argH ARP41667_T100 Q66J94_XENLA MGC81570 protein Xenopus laevis (African clawed frog) 443 92.00% Xenopus tropicalis (Western clawed frog) argH ARP41667_T100 A9JTM9_XENTR LOC100127798 protein (Silurana tropicalis) 464 92.00% Testis expressed gene 27 (Zinc finger, AN1‐ Xenopus tropicalis (Western clawed frog) ZFAND3 ARP34469_P050 Q28HC1_XENTR type domain 3) (Silurana tropicalis) 225 85.00% ZFAND3 ARP34469_P050 ZFAN3_XENLA AN1‐type zinc finger protein 3 homolog Xenopus laevis (African clawed frog) 226 85.00% Xenopus tropicalis (Western clawed frog) Odf2 ARP53603_P050 A4IHP0_XENTR Odf2 protein (Silurana tropicalis) 650 78.00%

Outer dense fiber protein 2 (Cenexin) (Outer Odf2 ARP53603_P050 ODFP2_XENLA dense fiber of sperm tails protein 2) Xenopus laevis (African clawed frog) 649 78.00% Xenopus tropicalis (Western clawed frog) Lrrc57 ARP55577_P050 B0JZU2_XENTR LOC100145243 protein (Silurana tropicalis) 238 76.00%

Lrrc57 ARP55577_P050 LRC57_XENLA Leucine‐rich repeat‐containing protein 57 Xenopus laevis (African clawed frog) 238 76.00% Bat2l ARP47973_P050 Q801N0_XENLA LOC398576 protein (Fragment) Xenopus laevis (African clawed frog) 488 76.00% ARP53106_P050 Q6NUG8_XENLA MGC78898 protein Xenopus laevis (African clawed frog) 187 92.00% Xenopus tropicalis (Western clawed frog) ARP53106_P050 Q66KE2_XENTR MGC89285 protein (Silurana tropicalis) 188 92.00% Xenopus tropicalis (Western clawed frog) Rtn3 ARP46812_P050 Q6IFY5_XENTR RTN4‐N (Silurana tropicalis) 193 85.00% Xenopus tropicalis (Western clawed frog) Rtn3 ARP46812_P050 Q6IFY4_XENTR RTN4‐B1 (Silurana tropicalis) 315 85.00% Xenopus tropicalis (Western clawed frog) Rtn3 ARP46812_P050 Q4FZ85_XENTR RTN4‐B2 (Silurana tropicalis) 334 85.00% Xenopus tropicalis (Western clawed frog) Rtn3 ARP46812_P050 Q4FZ84_XENTR RTN4‐C (Silurana tropicalis) 199 85.00% Xenopus tropicalis (Western clawed frog) Rtn3 ARP46812_P050 Q4FZ80_XENTR RTN4‐A1w (Fragment) (Silurana tropicalis) 459 85.00% Xenopus tropicalis (Western clawed frog) Rtn3 ARP46812_P050 B2GUC1_XENTR Rtn4 protein (Silurana tropicalis) 1063 85.00% Rtn3 ARP46812_P050 Q6PB23_XENLA RTN4.1‐C (Rtn4 protein) Xenopus laevis (African clawed frog) 199 78.00% Rtn3 ARP46812_P050 Q6JRW4_XENLA RTN4.2‐N Xenopus laevis (African clawed frog) 193 78.00% Rtn3 ARP46812_P050 Q6JRW3_XENLA RTN4.2‐C Xenopus laevis (African clawed frog) 199 78.00% Rtn3 ARP46812_P050 Q6JRW2_XENLA RTN4.2‐B3 Xenopus laevis (African clawed frog) 316 78.00% Rtn3 ARP46812_P050 Q6JRW1_XENLA RTN4.2‐B2 Xenopus laevis (African clawed frog) 323 78.00% Rtn3 ARP46812_P050 Q6JRW0_XENLA RTN4.2‐B1 Xenopus laevis (African clawed frog) 304 78.00% Rtn3 ARP46812_P050 Q6JRV9_XENLA RTN4.2‐A3 Xenopus laevis (African clawed frog) 1013 78.00% Rtn3 ARP46812_P050 Q6JRV8_XENLA RTN4.2‐A2 Xenopus laevis (African clawed frog) 1044 78.00% Rtn3 ARP46812_P050 Q6JRV7_XENLA RTN4.2‐A1 Xenopus laevis (African clawed frog) 1032 78.00% Rtn3 ARP46812_P050 Q6JRV6_XENLA Nogo‐C (RTN4.1‐N) Xenopus laevis (African clawed frog) 193 78.00% Rtn3 ARP46812_P050 Q6JRV4_XENLA RTN4.1‐B2 Xenopus laevis (African clawed frog) 330 78.00% Rtn3 ARP46812_P050 Q6JRV3_XENLA RTN4.1‐B1 Xenopus laevis (African clawed frog) 311 78.00% Rtn3 ARP46812_P050 Q6JRV2_XENLA RTN4.1‐A3 Xenopus laevis (African clawed frog) 1024 78.00% Rtn3 ARP46812_P050 Q6JRV1_XENLA RTN4.1‐A2 Xenopus laevis (African clawed frog) 1055 78.00% Rtn3 ARP46812_P050 Q6JRV0_XENLA RTN4.1‐A1 Xenopus laevis (African clawed frog) 1043 78.00% Rtn3 ARP46812_P050 Q5JBS0_XENLA Nogo‐A Xenopus laevis (African clawed frog) 1043 78.00% Rtn3 ARP46812_P050 Q5DQT9_XENLA Nogo‐B2 B isotype Xenopus laevis (African clawed frog) 303 78.00% Rtn3 ARP46812_P050 A5D8Q6_XENLA Putative uncharacterized protein Xenopus laevis (African clawed frog) 199 78.00% Gabpb1 ARP31189_P050 Q91923_XENLA XrpFIbeta1 Xenopus laevis (African clawed frog) 385 100.00% GA binding protein transcription factor, beta Xenopus tropicalis (Western clawed frog) Gabpb1 ARP31189_P050 Q68FB9_XENTR subunit 1 (Silurana tropicalis) 404 100.00% GA binding protein transcription factor, beta Xenopus tropicalis (Western clawed frog) Gabpb1 ARP31189_P050 Q28BY9_XENTR subunit 2 (Silurana tropicalis) 385 100.00% Gabpb1 ARP31189_P050 B7ZQV8_XENLA XrpFIbeta1 Xenopus laevis (African clawed frog) 385 100.00% Gabpb1 ARP31189_P050 Q91922_XENLA XrpFIbeta1 (Fragment) Xenopus laevis (African clawed frog) 301 92.00% Gabpb1 ARP31189_P050 Q7ZWX6_XENLA Gabpb1‐prov protein Xenopus laevis (African clawed frog) 385 92.00% Xenopus tropicalis (Western clawed frog) MTMR1 ARP42149_T100 Q28BS1_XENTR Myotubularin related protein 1 (Silurana tropicalis) 682 83.00%

Protein Smaug homolog 1 (Smaug 1) (Sterile Xenopus tropicalis (Western clawed frog) SAMD4B ARP53707_P050 SMAG1_XENTR alpha motif domain‐containing protein 4A) (Silurana tropicalis) 712 100.00%

Protein Smaug homolog 1 (Smaug 1) (Sterile SAMD4B ARP53707_P050 SMAG1_XENLA alpha motif domain‐containing protein 4A) Xenopus laevis (African clawed frog) 710 92.00% SAMD4B ARP53707_P050 Q58E80_XENLA MGC85001 protein Xenopus laevis (African clawed frog) 675 84.00% SAMD4B ARP53707_P050 Q6GLT9_XENLA MGC84256 protein Xenopus laevis (African clawed frog) 676 84.00% TSC22D3 ARP34697_P050 Q63ZU5_XENLA LOC494732 protein (TSC‐22 protein) Xenopus laevis (African clawed frog) 137 100.00% Xenopus tropicalis (Western clawed frog) TSC22D3 ARP34697_P050 Q5BL80_XENTR Tsc22d3 protein (Silurana tropicalis) 138 100.00% Xenopus tropicalis (Western clawed frog) TSC22D3 ARP34697_P050 B1H3H3_XENTR Putative uncharacterized protein (Silurana tropicalis) 910 100.00% TSC22D3 ARP34697_P050 Q7ZYC9_XENLA Dsipi‐prov protein Xenopus laevis (African clawed frog) 137 78.00% TSC22D3 ARP34697_P050 Q63ZK9_XENLA LOC494785 protein Xenopus laevis (African clawed frog) 137 78.00% Xenopus tropicalis (Western clawed frog) TSC22D3 ARP34697_P050 B1H322_XENTR LOC100145535 protein (Silurana tropicalis) 202 78.00% Xenopus tropicalis (Western clawed frog) TSC22D3 ARP34697_P050 B0BMP9_XENTR LOC100145088 protein (Silurana tropicalis) 137 78.00% Wdr34 ARP48430_P050 Q3KQ70_XENLA MGC130908 protein Xenopus laevis (African clawed frog) 503 90.00% Xenopus tropicalis (Western clawed frog) myl6 ARP57711_P050 B2GU22_XENTR LOC100158490 protein (Silurana tropicalis) 164 91.00% Myosin alkali light chain 6, smooth muscle form (Novel protein containing three EF hand Xenopus tropicalis (Western clawed frog) myl6 ARP57711_P050 Q6P7Z1_XENTR domains) (Silurana tropicalis) 151 84.00% myl6 ARP57711_P050 Q6NTJ0_XENLA LOC414678 protein (Fragment) Xenopus laevis (African clawed frog) 149 85.00% myl6 ARP57711_P050 Q6DKL8_XENLA LOC414678 protein Xenopus laevis (African clawed frog) 151 85.00% myl6 ARP57711_P050 Q68ET0_XENLA MGC84744 protein Xenopus laevis (African clawed frog) 151 85.00% myl6 ARP57711_P050 Q569Q7_XENLA LOC414678 protein Xenopus laevis (African clawed frog) 151 85.00% myl6 ARP57711_P050 Q498H8_XENLA MGC84744 protein Xenopus laevis (African clawed frog) 151 85.00% Xenopus tropicalis (Western clawed frog) myl6 ARP57711_P050 B0BM08_XENTR MGC76324 protein (Fragment) (Silurana tropicalis) 145 84.00% Xenopus tropicalis (Western clawed frog) SHOX2 ARP33286_T100 A6XEG9_XENTR Shox2 (Silurana tropicalis) 311 92.00%

Sodium‐dependent phosphate transporter 2 Xenopus tropicalis (Western clawed frog) SLC20A2 ARP42318_P050 S20A2_XENTR (Solute carrier family 20 member 2) (Silurana tropicalis) 653 100.00%

Sodium‐dependent phosphate transporter 2 SLC20A2 ARP42318_P050 S20A2_XENLA (Solute carrier family 20 member 2) Xenopus laevis (African clawed frog) 653 85.00%

Sodium‐dependent phosphate transporter 1‐B SLC20A2 ARP42318_P050 S20AB_XENLA (Solute carrier family 20 member 1‐B) Xenopus laevis (African clawed frog) 685 85.00%

Sodium‐dependent phosphate transporter 1 Xenopus tropicalis (Western clawed frog) SLC20A2 ARP42318_P050 S20A1_XENTR (Solute carrier family 20 member 1) (Silurana tropicalis) 685 85.00%

Sodium‐dependent phosphate transporter 1‐A SLC20A2 ARP42318_P050 S20AA_XENLA (Solute carrier family 20 member 1‐A) Xenopus laevis (African clawed frog) 685 78.00% Prdm9 ARP35668_T100 ZO22_XENLA Oocyte zinc finger protein XlCOF22 Xenopus laevis (African clawed frog) 435 100.00% Xenopus tropicalis (Western clawed frog) Prdm9 ARP35668_T100 Q28E42_XENTR Novel zinc finger protein (Fragment) (Silurana tropicalis) 303 90.00% KIF23 ARP33910_P050 Q5U4W5_XENLA LOC495418 protein Xenopus laevis (African clawed frog) 783 84.00% KIF23 ARP33910_P050 Q52KX0_XENLA LOC495418 protein (Fragment) Xenopus laevis (African clawed frog) 442 84.00% C2H2orf33 ARP49483_P050 MFF_XENLA Mitochondrial fission factor homolog A Xenopus laevis (African clawed frog) 219 84.00% C2H2orf33 ARP49483_P050 MFFB_XENLA Mitochondrial fission factor homolog B Xenopus laevis (African clawed frog) 239 84.00% MTHFD1 ARP46146_P050 Q7ZXF4_XENLA Mthfd1‐prov protein Xenopus laevis (African clawed frog) 934 76.00% Methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1, methenyltetrahydrofolate cyclohydrolase, Xenopus tropicalis (Western clawed frog) MTHFD1 ARP46146_P050 Q66JJ9_XENTR formyltetrahydrofolate synthetase (Silurana tropicalis) 934 76.00%

Methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1, methenyltetrahydrofolate cyclohydrolase, Xenopus tropicalis (Western clawed frog) MTHFD1 ARP46146_P050 Q28BS7_XENTR formyltetrahydrofolate synthetase (Silurana tropicalis) 934 76.00% Smox ARP53830_P050 Q5U4L6_XENLA LOC495472 protein Xenopus laevis (African clawed frog) 500 91.00% Smox ARP53830_P050 Q6INQ4_XENLA MGC81392 protein Xenopus laevis (African clawed frog) 534 75.00% Xenopus tropicalis (Western clawed frog) Smox ARP53830_P050 Q28C17_XENTR Spermine oxidase (Silurana tropicalis) 534 75.00% Xenopus tropicalis (Western clawed frog) dync1i1 ARP52048_P050 A8WGE7_XENTR Dync1i1 protein (Silurana tropicalis) 627 91.00% Xenopus tropicalis (Western clawed frog) POP4 ARP40674_T100 B1H2K3_XENTR Putative uncharacterized protein LOC550006 (Silurana tropicalis) 219 92.00% POP4 ARP40674_T100 Q6GM87_XENLA MGC82042 protein Xenopus laevis (African clawed frog) 223 84.00% Nkain4 ARP53118_P050 Q569R8_XENLA LOC733195 protein (Fragment) Xenopus laevis (African clawed frog) 204 100.00% Sodium/potassium‐transporting ATPase subunit beta‐1‐interacting protein 4 (Na(+)/K(+)‐transporting ATPase subunit beta‐ Xenopus tropicalis (Western clawed frog) Nkain4 ARP53118_P050 NKAI4_XENTR 1‐interacting protein 4) (Silurana tropicalis) 208 100.00% Sodium/potassium‐transporting ATPase subunit beta‐1‐interacting protein 4 (Na(+)/K(+)‐transporting ATPase subunit beta‐ Nkain4 ARP53118_P050 NKAI4_XENLA 1‐interacting protein 4) Xenopus laevis (African clawed frog) 208 100.00%

Sodium/potassium‐transporting ATPase subunit beta‐1‐interacting protein 1 (Na(+)/K(+)‐transporting ATPase subunit beta‐ Xenopus tropicalis (Western clawed frog) Nkain4 ARP53118_P050 NKAI1_XENTR 1‐interacting protein 1) (Protein FAM77C) (Silurana tropicalis) 207 78.00%

Sodium/potassium‐transporting ATPase subunit beta‐1‐interacting protein 1 (Na(+)/K(+)‐transporting ATPase subunit beta‐ Nkain4 ARP53118_P050 NKAI1_XENLA 1‐interacting protein 1) (Protein FAM77C) Xenopus laevis (African clawed frog) 207 78.00% Xenopus tropicalis (Western clawed frog) DAAM1 ARP55131_P050 A4IIL2_XENTR LOC100125016 protein (Fragment) (Silurana tropicalis) 494 78.00% COP9 constitutive photomorphogenic homolog subunit 4 (Arabidopsis) (Putative Xenopus tropicalis (Western clawed frog) cops4 ARP56841_P050 Q28J21_XENTR uncharacterized protein LOC549469) (Silurana tropicalis) 406 100.00% cops4 ARP56841_P050 A2RRW9_XENLA Cops4 protein Xenopus laevis (African clawed frog) 406 92.00% Xenopus tropicalis (Western clawed frog) DCUN1D1 ARP42570_P050 Q5BKG5_XENTR Dcun1d1 protein (Fragment) (Silurana tropicalis) 256 100.00% DCN1, defective in cullin neddylation 1, domain containing 1 (S. cerevisiae) (Dcun1d1 Xenopus tropicalis (Western clawed frog) DCUN1D1 ARP42570_P050 Q28GA7_XENTR protein) (Silurana tropicalis) 259 100.00% DCUN1D1 ARP42570_P050 Q6NU45_XENLA MGC81257 protein Xenopus laevis (African clawed frog) 259 100.00% DP1alpha ARP51031_P050 Q66KI2_XENLA MGC81762 protein Xenopus laevis (African clawed frog) 412 78.00% DP1alpha ARP51031_P050 Q63ZR9_XENLA LOC494744 protein Xenopus laevis (African clawed frog) 409 78.00%

DP1alpha ARP51031_P050 B2L460_XENBO Transcription factor Dp‐1 alpha (Fragment) Xenopus borealis (Kenyan clawed frog) 47 78.00% Hypothetical LOC496643 (LOC496643 protein) Xenopus tropicalis (Western clawed frog) DP1alpha ARP51031_P050 Q5M8Z8_XENTR (Transcription factor Dp‐1) (Silurana tropicalis) 411 78.00% MrHox9/10 ARP39932_P050 Q91528_XENBO Homeobox protein (Fragment) Xenopus borealis (Kenyan clawed frog) 78 100.00% MrHox9/10 ARP39932_P050 Q90YD9_XENLA Homebox protein Hoxa9 (Fragment) Xenopus laevis (African clawed frog) 75 100.00% MrHox9/10 ARP39932_P050 A2BD86_XENLA LOC100037070 protein Xenopus laevis (African clawed frog) 261 100.00% Xenopus tropicalis (Western clawed frog) MrHox9/10 ARP39932_P050 Q6PBD8_XENTR Homeo box B9 (Homeobox B9) (Silurana tropicalis) 247 92.00% MrHox9/10 ARP39932_P050 Q3KQ20_XENLA Putative uncharacterized protein Xenopus laevis (African clawed frog) 232 92.00% MrHox9/10 ARP39932_P050 HXB9_XENLA Homeobox protein Hox‐B9 (XlHbox‐6) Xenopus laevis (African clawed frog) 232 92.00% Xenopus tropicalis (Western clawed frog) MrHox9/10 ARP39932_P050 Q28J56_XENTR Homeo box C9 (Silurana tropicalis) 100 84.00% Xenopus tropicalis (Western clawed frog) MrHox9/10 ARP39932_P050 Q0D2A5_XENTR Putative uncharacterized protein (Fragment) (Silurana tropicalis) 212 84.00% MrHox9/10 ARP39932_P050 A0JMS5_XENLA Putative uncharacterized protein Xenopus laevis (African clawed frog) 273 84.00% MrHox9/10 ARP39932_P050 Q90YE0_XENLA Homeobox protein Hox A11 (Fragment) Xenopus laevis (African clawed frog) 185 85.00% Homeobox containing transcription factor MrHox9/10 ARP39932_P050 O73794_XENLA (Fragment) Xenopus laevis (African clawed frog) 63 78.00% MrHox9/10 ARP39932_P050 Q1RMD8_XENLA MGC131014 protein Xenopus laevis (African clawed frog) 274 78.00% ARP38482_P050 Q4QR28_XENLA Hoxb7 protein Xenopus laevis (African clawed frog) 221 100.00% Homeobox protein Hox‐B7‐B (P52) (XlHbox‐2 ARP38482_P050 HXB7B_XENLA B) Xenopus laevis (African clawed frog) 220 100.00% Homeobox protein Hox‐B7‐A (MM3) (XlHbox‐ ARP38482_P050 HXB7A_XENLA 2 A) Xenopus laevis (African clawed frog) 220 100.00% Xenopus tropicalis (Western clawed frog) ARP38482_P050 Q5M797_XENTR Homeobox A5 (Silurana tropicalis) 274 91.00% Xenopus tropicalis (Western clawed frog) ARP38482_P050 A4QNI0_XENTR Hoxb5 protein (Silurana tropicalis) 258 91.00% YBX1 ARP34396_P050 A1L3K8_XENLA LOC100037035 protein Xenopus laevis (African clawed frog) 322 100.00% YBX1 ARP34396_P050 Q8AVK9_XENLA Nsep1 protein Xenopus laevis (African clawed frog) 304 85.00% YBX1 ARP34396_P050 YB3_XENLA B box‐binding protein (Protein YB3) Xenopus laevis (African clawed frog) 305 85.00% Nuclease sensitive element binding protein 1 Xenopus tropicalis (Western clawed frog) YBX1 ARP34396_P050 Q28IU4_XENTR (Y box binding protein 1) (Silurana tropicalis) 306 78.00% Xenopus tropicalis (Western clawed frog) ARP34064_P050 B3DLU7_XENTR Supt5h protein (Silurana tropicalis) 1078 85.00% ARP34064_P050 A1L1H7_XENLA LOC733281 protein Xenopus laevis (African clawed frog) 1083 85.00%

ORF Names:zgc:154042 ZFIN ZDB‐GENE‐ 061103‐88OrganismDanio rerio (Zebrafish) (Brachydanio rerio) ARP55993_P050 Q766Z1_XENLA Cytochrome P450 Xenopus laevis (African clawed frog) 520 91.00%

ORF Names:zgc:154042 ZFIN ZDB‐GENE‐ 061103‐88OrganismDanio rerio Cytochrome P450, family 4, subfamily V, Xenopus tropicalis (Western clawed frog) (Zebrafish) (Brachydanio rerio) ARP55993_P050 Q08D20_XENTR polypeptide 2 (Silurana tropicalis) 523 91.00%

ORF Names:zgc:154042 ZFIN ZDB‐GENE‐ 061103‐88OrganismDanio rerio (Zebrafish) (Brachydanio rerio) ARP55993_P050 Q6GMD7_XENLA MGC81840 protein Xenopus laevis (African clawed frog) 522 83.00% UNCX ARP47548_P050 Q7ZXS0_XENLA Uncx4.1‐prov protein Xenopus laevis (African clawed frog) 163 91.00% Xenopus tropicalis (Western clawed frog) sil1 ARP44848_P050 A4II02_XENTR Sil1 protein (Silurana tropicalis) 453 84.00% sil1 ARP44848_P050 SIL1_XENLA Nucleotide exchange factor SIL1 Xenopus laevis (African clawed frog) 456 84.00% ERG ARP57967_P050 Q9W700_XENLA Erg protein Xenopus laevis (African clawed frog) 485 85.00% ERG ARP57967_P050 Q9W6Z9_XENLA Erg protein Xenopus laevis (African clawed frog) 456 85.00% ERG ARP57967_P050 Q6GNZ9_XENLA MGC80765 protein Xenopus laevis (African clawed frog) 485 85.00% ERG ARP57967_P050 B7ZSD3_XENLA Erg gene (Erg_E) Xenopus laevis (African clawed frog) 456 85.00% Xenopus tropicalis (Western clawed frog) ERG ARP57967_P050 B4F6M4_XENTR Putative uncharacterized protein (Silurana tropicalis) 458 85.00% ARP47825_P050 Q2T9K7_XENLA MGC130987 protein Xenopus laevis (African clawed frog) 256 76.00% Caudal type homeo box transcription factor 1 Xenopus tropicalis (Western clawed frog) ARP47825_P050 Q07G97_XENTR (Fragment) (Silurana tropicalis) 202 100.00% ARP47825_P050 Q03922_XENLA Xcad 2 protein (Fragment) Xenopus laevis (African clawed frog) 141 100.00% Xenopus tropicalis (Western clawed frog) ARP47825_P050 B7ZUR8_XENTR Caudal type homeobox 1 (Silurana tropicalis) 262 100.00% ARP47825_P050 A6H8J8_XENLA XCAD2 protein Xenopus laevis (African clawed frog) 263 100.00% Xenopus tropicalis (Western clawed frog) ARP47825_P050 CDX1_XENTR Homeobox protein CDX‐1 (Silurana tropicalis) 262 100.00% ARP47825_P050 CDX1_XENLA Homeobox protein CDX‐1 (xCAD2) Xenopus laevis (African clawed frog) 263 100.00% ARP47825_P050 Q91768_XENLA Xcad 1 protein (Fragment) Xenopus laevis (African clawed frog) 157 100.00%

Cad1 (Caudal type homeo box transcription Xenopus tropicalis (Western clawed frog) ARP47825_P050 Q90X90_XENTR factor 2) (Caudal type homeobox 2) (Silurana tropicalis) 252 100.00% Xenopus tropicalis (Western clawed frog) ARP47825_P050 Q90X88_XENTR Cad3 (Caudal type homeobox 4) (Silurana tropicalis) 260 90.00% ARP47825_P050 Q7T0X3_XENLA Cdx4 protein Xenopus laevis (African clawed frog) 260 90.00% ARP47825_P050 Q32NU3_XENLA Cdx4 protein Xenopus laevis (African clawed frog) 260 90.00% ARP47825_P050 Q32NJ4_XENLA Putative uncharacterized protein Xenopus laevis (African clawed frog) 254 100.00% Xenopus tropicalis (Western clawed frog) ARP47825_P050 B1H2D1_XENTR LOC100145392 protein (Silurana tropicalis) 270 90.00% ARP40750_P050 Q4QR27_XENLA LOC733270 protein (Fragment) Xenopus laevis (African clawed frog) 666 83.00% ARP40750_P050 Q2VPI2_XENLA MGC132026 protein Xenopus laevis (African clawed frog) 667 83.00% ARP40750_P050 Q2VPG6_XENLA Putative uncharacterized protein Xenopus laevis (African clawed frog) 671 83.00% ORF Names:zgc:162164 EMBL AAI39532.1 ZFIN ZDB‐GENE‐070410‐ 28OrganismDanio rerio (Zebrafish) (Brachydanio rerio) ARP43383_T100 Q5U4V7_XENLA LOC495424 protein Xenopus laevis (African clawed frog) 259 85.00% ORF Names:zgc:162164 EMBL AAI39532.1 ZFIN ZDB‐GENE‐070410‐ 28OrganismDanio rerio (Zebrafish) Xenopus tropicalis (Western clawed frog) (Brachydanio rerio) ARP43383_T100 A9JTQ9_XENTR Ube2j2 protein (Silurana tropicalis) 259 85.00%

ORF Names:GSTENG00021251001 EMBL CAG02231.1OrganismTetraodon Xenopus tropicalis (Western clawed frog) nigroviridis (Green puffer) ARP40031_P050 B5DE12_XENTR Putative uncharacterized protein (Silurana tropicalis) 645 92.00%

ORF Names:GSTENG00021251001 EMBL CAG02231.1OrganismTetraodon Forkhead box protein K2 (FoxK2) (Interleukin nigroviridis (Green puffer) ARP40031_P050 FOXK2_XENLA enhancer‐binding factor 1) (ILF1) (xFoxK1) Xenopus laevis (African clawed frog) 642 91.00% Csnk1a1 ARP51843_P050 Q7ZY65_XENLA Csnk1a1‐prov protein Xenopus laevis (African clawed frog) 337 100.00% Casein kinase I isoform alpha (CKI‐alpha) (EC Csnk1a1 ARP51843_P050 KC1A_XENLA 2.7.11.1) (CK1) Xenopus laevis (African clawed frog) 337 100.00% ARP40211_T100 Q7ZWY6_XENLA Rpl9‐prov protein Xenopus laevis (African clawed frog) 192 100.00% ARP52217_P050 Q6GPQ2_XENLA MGC82693 protein Xenopus laevis (African clawed frog) 854 85.00% ARP52217_P050 Q1PAH4_XENLA Heat shock protein 110 Xenopus laevis (African clawed frog) 854 85.00% ARP52217_P050 Q6DE28_XENLA Hsp105‐prov protein Xenopus laevis (African clawed frog) 852 85.00%

ORF Names:v1g168210OrganismNematostel la vectensis (Starlet sea anemone) ARP50492_P050 A2VDC8_XENLA LOC100037221 protein (Fragment) Xenopus laevis (African clawed frog) 351 100.00% Eukaryotic translation initiation factor 3 ORF subunit H (eIF3h) (Eukaryotic translation Names:v1g168210OrganismNematostel initiation factor 3 subunit 3) (eIF‐3‐gamma) Xenopus tropicalis (Western clawed frog) la vectensis (Starlet sea anemone) ARP50492_P050 EIF3H_XENTR (eIF3 p40 subunit) (Silurana tropicalis) 335 92.00% Eukaryotic translation initiation factor 3 ORF subunit H (eIF3h) (Eukaryotic translation Names:v1g168210OrganismNematostel initiation factor 3 subunit 3) (eIF‐3‐gamma) la vectensis (Starlet sea anemone) ARP50492_P050 EIF3H_XENLA (eIF3 p40 subunit) Xenopus laevis (African clawed frog) 334 85.00% ARP32142_P050 Q6DE65_XENLA MGC80050 protein Xenopus laevis (African clawed frog) 76 85.00% Xenopus tropicalis (Western clawed frog) ARP32142_P050 B3DM21_XENTR LOC100170591 protein (Silurana tropicalis) 76 85.00% ARP32142_P050 Q6GM97_XENLA MGC81992 protein Xenopus laevis (African clawed frog) 75 85.00% ARP32142_P050 Q4KLT7_XENLA MGC115377 protein Xenopus laevis (African clawed frog) 75 85.00% Novel protein (Putative uncharacterized Xenopus tropicalis (Western clawed frog) ARP32142_P050 Q28JA7_XENTR protein LOC549498) (Silurana tropicalis) 75 85.00%

ORF Names:v1g79420OrganismNematostell a vectensis (Starlet sea anemone) ARP49643_P050 Q7SYX3_XENLA Apmcf1‐prov protein Xenopus laevis (African clawed frog) 264 100.00%

ORF Names:v1g79420OrganismNematostell Xenopus tropicalis (Western clawed frog) a vectensis (Starlet sea anemone) ARP49643_P050 Q6P860_XENTR Signal recognition particle receptor, B subunit (Silurana tropicalis) 249 100.00% Xenopus tropicalis (Western clawed frog) DLX1 ARP40020_P050 A0PJP5_XENTR Dlx1 protein (Silurana tropicalis) 251 92.00% Xenopus tropicalis (Western clawed frog) ARP32439_P050 OTX2_XENTR Homeobox protein OTX2 (Orthodenticle 2) (Silurana tropicalis) 289 92.00% Homeobox protein OTX2‐B (xOTX2‐B) (Orthodenticle 2‐B) (Orthodenticle‐A‐like ARP32439_P050 OTX2B_XENLA protein B) Xenopus laevis (African clawed frog) 289 92.00% Homeobox protein OTX2‐A (xOTX2‐A) (Orthodenticle 2‐A) (Orthodenticle‐A‐like ARP32439_P050 OTX2A_XENLA protein A) Xenopus laevis (African clawed frog) 288 92.00% Xenopus tropicalis (Western clawed frog) TEAD1 ARP34065_P050 B2GU39_XENTR Tead1 protein (Fragment) (Silurana tropicalis) 513 84.00% TEAD1 ARP34065_P050 A8CSN2_XENLA TEF‐1 Xenopus laevis (African clawed frog) 426 84.00% TEAD1 ARP34065_P050 Q641H5_XENLA MGC81567 protein Xenopus laevis (African clawed frog) 433 76.00% sept2‐B ARP56660_P050 B7ZR20_XENLA Septin A Xenopus laevis (African clawed frog) 356 78.00% Xenopus tropicalis (Western clawed frog) sept2‐B ARP56660_P050 SEP2B_XENTR Septin‐2B (Silurana tropicalis) 355 78.00% sept2‐B ARP56660_P050 SEP2B_XENLA Septin‐2B Xenopus laevis (African clawed frog) 352 78.00% sept2‐B ARP56660_P050 SEP2A_XENLA Septin‐2A (Septin‐A) (XlSeptA) Xenopus laevis (African clawed frog) 356 78.00% Xenopus tropicalis (Western clawed frog) smad4 ARP32005_T100 A4II45_XENTR Smad4 protein (Fragment) (Silurana tropicalis) 482 100.00% ARP45628_P050 Q9W745_XENLA COUP transcription factor 1 Xenopus laevis (African clawed frog) 411 78.00% ARP45628_P050 Q6DCH6_XENLA Nr2f2 protein Xenopus laevis (African clawed frog) 404 78.00% Xenopus tropicalis (Western clawed frog) ARP45628_P050 A4QNF4_XENTR Nr2f1 protein (Silurana tropicalis) 410 78.00% nfasca ARP44832_P050 Q6GQB1_XENLA MGC80200 protein Xenopus laevis (African clawed frog) 1177 76.00% Xenopus tropicalis (Western clawed frog) nfasca ARP44832_P050 B5DE72_XENTR Putative uncharacterized protein (Silurana tropicalis) 1294 76.00% ORF Names:GSPATT00035237001 EMBL CAK66108.1OrganismParamecium Xenopus tropicalis (Western clawed frog) tetraurelia ARP40178_P050 Q6P367_XENTR Tubulin, beta 2B (Silurana tropicalis) 445 100.00% ORF Names:GSPATT00035237001 EMBL CAK66108.1OrganismParamecium tetraurelia ARP40178_P050 TBB2_XENLA Tubulin beta‐2 chain (Beta‐2‐tubulin) Xenopus laevis (African clawed frog) 443 100.00% ORF Names:GSPATT00035237001 EMBL CAK66108.1OrganismParamecium tetraurelia ARP40178_P050 Q7ZY50_XENLA MGC53997 protein Xenopus laevis (African clawed frog) 445 85.00% ORF Names:GSPATT00035237001 EMBL CAK66108.1OrganismParamecium Xenopus tropicalis (Western clawed frog) tetraurelia ARP40178_P050 Q0IIR4_XENTR Tubulin, beta 2C (Silurana tropicalis) 445 85.00% ORF Names:GSPATT00035237001 EMBL CAK66108.1OrganismParamecium tetraurelia ARP40178_P050 B2L4V2_XENBO Tubulin beta‐2C chain (Fragment) Xenopus borealis (Kenyan clawed frog) 30 85.00% ORF Names:GSPATT00035237001 EMBL CAK66108.1OrganismParamecium tetraurelia ARP40178_P050 TBB4_XENLA Tubulin beta‐4 chain Xenopus laevis (African clawed frog) 445 85.00%

Mediator of RNA polymerase II transcription Xenopus tropicalis (Western clawed frog) Med8 ARP52440_P050 MED8_XENTR subunit 8 (Mediator complex subunit 8) (Silurana tropicalis) 267 92.00%

Mediator of RNA polymerase II transcription Med8 ARP52440_P050 MED8B_XENLA subunit 8‐B (Mediator complex subunit 8‐B) Xenopus laevis (African clawed frog) 269 92.00%

Mediator of RNA polymerase II transcription Med8 ARP52440_P050 MED8A_XENLA subunit 8‐A (Mediator complex subunit 8‐A) Xenopus laevis (African clawed frog) 268 92.00% Xenopus tropicalis (Western clawed frog) Trim62 ARP34576_P050 B1H180_XENTR LOC100145315 protein (Silurana tropicalis) 475 85.00% Lef1 ARP32403_T100 Q9YHZ3_XENLA Lymphoid enhancer factor 1 Xenopus laevis (African clawed frog) 372 100.00% Lef1 ARP32403_T100 Q90ZB8_XENLA Lymphoid enhancer factor XLEF‐1 Xenopus laevis (African clawed frog) 372 100.00% Lef1 ARP32403_T100 Q90ZB7_XENLA Lymphoid enhancer factor XLEF‐1B Xenopus laevis (African clawed frog) 372 100.00% Lymphoid enhancer binding factor 1 Lef1 ARP32403_T100 B2L4E5_XENBO (Fragment) Xenopus borealis (Kenyan clawed frog) 339 92.00% RPH3A AVARP13088_P050 Q6DDV6_XENLA Rph3a‐prov protein Xenopus laevis (African clawed frog) 692 92.00% DLC1 ARP52138_P050 Q6NRF8_XENLA MGC83845 protein Xenopus laevis (African clawed frog) 1049 92.00% Aspn ARP42487_T100 Q5XHD6_XENLA LOC495030 protein Xenopus laevis (African clawed frog) 379 78.00%

ORF Names:v1g85827OrganismNematostell a vectensis (Starlet sea anemone) ARP48028_P050 Q08B02_XENLA LOC100158372 protein Xenopus laevis (African clawed frog) 676 84.00%

ORF Names:v1g85827OrganismNematostell Xenopus tropicalis (Western clawed frog) a vectensis (Starlet sea anemone) ARP48028_P050 B1H1B4_XENTR LOC100145334 protein (Fragment) (Silurana tropicalis) 390 78.00% ORF Names:OsJ_07368 EMBL EAZ23666.1OrganismOryza sativa subsp. japonica (Rice) ARP38587_P050 A9ULW4_XENLA LOC100137630 protein (Fragment) Xenopus laevis (African clawed frog) 376 87.00%

ORF Names:OsJ_07368 EMBL AT‐rich interactive domain‐containing protein EAZ23666.1OrganismOryza sativa 3A (ARID domain‐containing protein 3A) Xenopus tropicalis (Western clawed frog) subsp. japonica (Rice) ARP38587_P050 ARI3A_XENTR (Bright homolog) (Dead ringer‐like protein 1) (Silurana tropicalis) 541 87.00%

ORF Names:OsJ_07368 EMBL AT‐rich interactive domain‐containing protein EAZ23666.1OrganismOryza sativa 3A (ARID domain‐containing protein 3A) subsp. japonica (Rice) ARP38587_P050 ARI3A_XENLA (Bright homolog) (Dead ringer‐like protein 1) Xenopus laevis (African clawed frog) 539 87.00% ARP38232_T100 D2WK21_XENLA Sex‐determining region Y‐box 2 Xenopus laevis (African clawed frog) 311 100.00% Xenopus tropicalis (Western clawed frog) ARP38232_T100 SOX3_XENTR Transcription factor Sox‐3 (Silurana tropicalis) 307 100.00% Transcription factor Sox‐3‐B (Transcription ARP38232_T100 SOX3B_XENLA factor Sox‐11) (xSox‐11) Xenopus laevis (African clawed frog) 307 100.00%

ARP38232_T100 SOX3A_XENLA Transcription factor Sox‐3‐A (xSox3) (xSox‐B1) Xenopus laevis (African clawed frog) 309 100.00% Transcription factor Sox‐2 (SRY (sex Xenopus tropicalis (Western clawed frog) ARP38232_T100 SOX2_XENTR determining region Y)‐box 2) (Silurana tropicalis) 311 100.00%

Transcription factor Sox‐2 (XSox2) (XlSox‐2) ARP38232_T100 SOX2_XENLA (SRY (sex determining region Y)‐box 2) Xenopus laevis (African clawed frog) 311 100.00% Transcription factor Sox‐21 (SRY (sex ARP38232_T100 SOX21_XENLA determining region Y)‐box 21) Xenopus laevis (African clawed frog) 262 100.00% Transcription factor Sox‐1 (SRY (Sex Xenopus tropicalis (Western clawed frog) ARP38232_T100 SOX1_XENTR determining region Y)‐box 1) (Silurana tropicalis) 401 100.00%

Transcription factor Sox‐1 (XlSox1) (xSox1) ARP38232_T100 SOX1_XENLA (SRY (sex determining region Y)‐box 1) Xenopus laevis (African clawed frog) 393 100.00% Transcription factor Sox‐14 (SRY (sex Xenopus tropicalis (Western clawed frog) ARP38232_T100 SOX14_XENTR determining region Y)‐box 14) (Silurana tropicalis) 239 100.00% Transcription factor Sox‐14 (SRY (sex ARP38232_T100 SOX14_XENLA determining region Y)‐box 14) Xenopus laevis (African clawed frog) 239 100.00% Xenopus tropicalis (Western clawed frog) hectd2 ARP43480_P050 A8E4U9_XENTR LOC100127570 protein (Silurana tropicalis) 753 92.00% Xenopus tropicalis (Western clawed frog) nkx6‐1 ARP32720_P050 A5YC50_XENTR NK6 transcription factor related locus 1 (Silurana tropicalis) 342 100.00% nkx6‐1 ARP32720_P050 A5YC48_XENLA NK6 transcription factor related locus 1 Xenopus laevis (African clawed frog) 351 100.00% nkx6‐1 ARP32720_P050 Q0IHB4_XENLA Nkx6‐2 protein Xenopus laevis (African clawed frog) 281 85.00% scoB ARP48481_P050 Q7ZYR2_XENLA MGC69180 protein (Fragment) Xenopus laevis (African clawed frog) 529 100.00% scoB ARP48481_P050 Q6PCE5_XENLA MGC69180 protein Xenopus laevis (African clawed frog) 530 100.00% Xenopus tropicalis (Western clawed frog) scoB ARP48481_P050 Q66KJ2_XENTR Oxct1 protein (Silurana tropicalis) 530 100.00%

ORF Names:IscW_ISCW021819 EMBL EEC14519.1OrganismIxodes scapularis (Black‐legged tick) (Deer tick) ARP32960_P050 B7ZRR5_XENLA Xebf‐3 protein Xenopus laevis (African clawed frog) 597 100.00%

ORF Names:IscW_ISCW021819 EMBL EEC14519.1OrganismIxodes scapularis Transcription factor COE3 (xCOE3) (Olf‐1/EBF‐ (Black‐legged tick) (Deer tick) ARP32960_P050 COE3_XENLA like 2) (OE‐2) (xEBF‐3) (xOE‐2) Xenopus laevis (African clawed frog) 598 100.00%

ORF Names:IscW_ISCW021819 EMBL EEC14519.1OrganismIxodes scapularis (Black‐legged tick) (Deer tick) ARP32960_P050 COE2B_XENLA Isoform 2 Xenopus laevis (African clawed frog) 572 78.00%

ORF Names:IscW_ISCW021819 EMBL EEC14519.1OrganismIxodes scapularis Transcription factor coe2 (Early B‐cell factor 2) Xenopus tropicalis (Western clawed frog) (Black‐legged tick) (Deer tick) ARP32960_P050 COE2_XENTR (EBF‐2) (Silurana tropicalis) 575 78.00%

ORF Names:IscW_ISCW021819 EMBL EEC14519.1OrganismIxodes scapularis Transcription factor coe2‐B (Xcoe2) (Early B‐ (Black‐legged tick) (Deer tick) ARP32960_P050 COE2B_XENLA cell factor 2‐B) (EBF‐2‐B) (Xebf‐2‐B) Xenopus laevis (African clawed frog) 580 78.00%

ORF Names:IscW_ISCW021819 EMBL EEC14519.1OrganismIxodes scapularis Transcription factor coe2‐A (Xcoe‐2) (Xcoe2) (Black‐legged tick) (Deer tick) ARP32960_P050 COE2A_XENLA (Early B‐cell factor 2‐A) (EBF‐2‐A) (Xebf‐2‐A) Xenopus laevis (African clawed frog) 575 78.00% Xenopus tropicalis (Western clawed frog) ARP33904_P050 B3DLW6_XENTR Kif5b protein (Silurana tropicalis) 962 85.00% ARP33904_P050 A5XAW2_XENLA Kinesin heavy chain (Fragment) Xenopus laevis (African clawed frog) 962 78.00% Xenopus tropicalis (Western clawed frog) SNAI2 ARP33302_P050 Q90VW4_XENTR Zinc finger transcription factor slug (Silurana tropicalis) 266 85.00% Zinc finger protein SNAI2 (Protein slug‐alpha) (Protein snail homolog 2) (Snail protein SNAI2 ARP33302_P050 SNAI2_XENLA homolog Slug) (xSlu) Xenopus laevis (African clawed frog) 266 85.00% LOC398235 protein (Zinc finger transcription SNAI2 ARP33302_P050 Q90VW5_XENLA factor slug beta) Xenopus laevis (African clawed frog) 266 78.00% SNAI2 ARP33302_P050 Q6IP32_XENLA LOC398235 protein Xenopus laevis (African clawed frog) 266 78.00% Snail homolog 2 (Snail homolog 2 Xenopus tropicalis (Western clawed frog) SNAI2 ARP33302_P050 Q6DJ09_XENTR (Drosophila)) (Silurana tropicalis) 266 78.00% Xenopus tropicalis (Western clawed frog) ARP32731_P050 Q07G92_XENTR Zinc finger protein 295 (Fragment) (Silurana tropicalis) 445 85.00% Xenopus tropicalis (Western clawed frog) znf295 ARP32731_P050 A1A5F0_XENTR Znf295 protein (Silurana tropicalis) 1030 85.00% Xenopus tropicalis (Western clawed frog) Acbd5 ARP44943_P050 ACBD5_XENTR Acyl‐CoA‐binding domain‐containing protein 5 (Silurana tropicalis) 458 92.00%

Acbd5 ARP44943_P050 ACBD5_XENLA Acyl‐CoA‐binding domain‐containing protein 5 Xenopus laevis (African clawed frog) 467 92.00% Structural maintenance of chromosomes SMC3 ARP47590_P050 Q8AW91_XENLA protein 3 Xenopus laevis (African clawed frog) 1217 100.00% RFC3 ARP46085_P050 Q4QQP4_XENLA MGC115007 protein Xenopus laevis (African clawed frog) 356 85.00% HPRT1 ARP48471_P050 Q7ZY82_XENLA Hprt protein (Fragment) Xenopus laevis (African clawed frog) 184 100.00% Xenopus tropicalis (Western clawed frog) HPRT1 ARP48471_P050 Q6P2Z2_XENTR Hypoxanthine phosphoribosyltransferase 1 (Silurana tropicalis) 216 100.00% HPRT1 ARP48471_P050 Q6DDP6_XENLA Prtfdc1 protein Xenopus laevis (African clawed frog) 216 100.00%

Hypoxanthine phosphoribosyltransferase 1 Xenopus tropicalis (Western clawed frog) HPRT1 ARP48471_P050 Q28HG9_XENTR (Lesch‐Nyhan syndrome) (Fragment) (Silurana tropicalis) 235 100.00% ARP56329_P050 Q7ZTJ4_XENLA Vha55 protein Xenopus laevis (African clawed frog) 511 86.00%

ATPase, H+ transporting, lysosomal (Vacuolar Xenopus tropicalis (Western clawed frog) ARP56329_P050 Q0VGW2_XENTR proton pump), beta 56/58 kDa, isoform 2 (Silurana tropicalis) 505 86.00%

Heterogeneous nuclear ribonucleoprotein D‐ Hnrpdl ARP40586_P050 B2L570_XENBO like protein (Fragment) Xenopus borealis (Kenyan clawed frog) 41 92.00%

Heterogeneous nuclear ribonucleoprotein D‐ Xenopus tropicalis (Western clawed frog) Hnrpdl ARP40586_P050 HNRDL_XENTR like (hnRNP D‐like) (hnRNP DL) (Silurana tropicalis) 297 92.00%

Heterogeneous nuclear ribonucleoprotein D‐ Hnrpdl ARP40586_P050 HNDLB_XENLA like‐B (hnRNP D‐like B) (hnRNP DL‐B) Xenopus laevis (African clawed frog) 291 92.00%

Heterogeneous nuclear ribonucleoprotein D‐ Hnrpdl ARP40586_P050 HNDLA_XENLA like‐A (hnRNP D‐like A) (hnRNP DL‐A) Xenopus laevis (African clawed frog) 293 92.00% ORF Names:PANDA_007911 EMBL EFB15986.1OrganismAiluropoda melanoleuca (Giant panda) ARP44708_P050 Q6NRH6_XENLA MGC83809 protein Xenopus laevis (African clawed frog) 509 100.00% ORF Names:PANDA_007911 EMBL EFB15986.1OrganismAiluropoda Transmembrane and coiled‐coil domain family Xenopus tropicalis (Western clawed frog) melanoleuca (Giant panda) ARP44708_P050 Q0IHU7_XENTR 2 (Silurana tropicalis) 725 92.00% ORF Names:PANDA_007911 EMBL EFB15986.1OrganismAiluropoda Xenopus tropicalis (Western clawed frog) melanoleuca (Giant panda) ARP44708_P050 Q0VA50_XENTR Putative uncharacterized protein MGC145249 (Silurana tropicalis) 473 85.00% Xenopus tropicalis (Western clawed frog) Rpn2 ARP45400_P050 Q5I083_XENTR Hypothetical LOC496959 (Ribophorin II) (Silurana tropicalis) 631 91.00% RNA binding protein fox‐1 homolog 2 (Fox‐1 homolog B) (RNA‐binding motif protein 9) Xenopus tropicalis (Western clawed frog) Rbfox2 ARP40339_P050 RFOX2_XENTR (RNA‐binding protein 9) (Silurana tropicalis) 380 85.00% Rbfox2 ARP40339_P050 Q6IP88_XENLA MGC78805 protein Xenopus laevis (African clawed frog) 162 78.00% LOC100127308 protein (Putative Rbfox2 ARP40339_P050 A9JS52_XENLA uncharacterized protein LOC100127308) Xenopus laevis (African clawed frog) 381 76.00% ARP39167_P050 D0E8G8_XENLA Zinc finger protein 423 Xenopus laevis (African clawed frog) 1289 92.00% znf423 ARP39167_P050 ZN521_XENLA Zinc finger protein 521 Xenopus laevis (African clawed frog) 1310 100.00% Elavl4 ARP40971_P050 ELAV4_XENLA Isoform 3 Xenopus laevis (African clawed frog) 395 92.00% Elavl4 ARP40971_P050 ELAV4_XENLA Isoform 1 (Isoform ELRD1) Xenopus laevis (African clawed frog) 366 92.00% Xenopus tropicalis (Western clawed frog) Elavl4 ARP40971_P050 ELAV4_XENTR ELAV‐like protein 4 (Protein ElrD) (Silurana tropicalis) 400 92.00% Elavl4 ARP40971_P050 ELAV4_XENLA ELAV‐like protein 4 (Protein ElrD) Xenopus laevis (African clawed frog) 400 92.00% Xenopus tropicalis (Western clawed frog) SOX9 ARP37986_P050 SOX9_XENTR Transcription factor Sox‐9 (Xt‐sox9) (Silurana tropicalis) 482 100.00% SOX9 ARP37986_P050 SOX9B_XENLA Transcription factor Sox‐9‐B Xenopus laevis (African clawed frog) 476 100.00% SOX9 ARP37986_P050 SOX9A_XENLA Transcription factor Sox‐9‐A Xenopus laevis (African clawed frog) 477 100.00% Transcription factor Sox‐10 (SRY (sex Xenopus tropicalis (Western clawed frog) SOX9 ARP37986_P050 SOX10_XENTR determining region Y)‐box 10) (Silurana tropicalis) 436 85.00% Transcription factor Sox‐10 (SRY (sex SOX9 ARP37986_P050 SOX10_XENLA determining region Y)‐box 10) Xenopus laevis (African clawed frog) 446 85.00% Potassium inwardly‐rectifying channel ARP35169_P050 E3VVT3_XENLA subfamily J member 8 Xenopus laevis (African clawed frog) 413 100.00% Xenopus tropicalis (Western clawed frog) kcnj8 ARP35169_P050 A4IHW7_XENTR LOC100124909 protein (Silurana tropicalis) 413 100.00% ORF Names:NFIA_008250 EMBL EAW22148.1OrganismNeosartorya fischeri (strain ATCC 1020 / DSM 3700 / FGSC A1164 / NRRL 181) (Aspergillus fischerianus) ARP48167_T100 Q7SZ09_XENLA MGC64329 protein Xenopus laevis (African clawed frog) 436 83.00% ORF Names:NFIA_008250 EMBL EAW22148.1OrganismNeosartorya fischeri (strain ATCC 1020 / DSM 3700 / FGSC A1164 / NRRL 181) (Aspergillus fischerianus) ARP48167_T100 Q5XH49_XENLA Putative uncharacterized protein Xenopus laevis (African clawed frog) 447 83.00% ORF Names:NFIA_008250 EMBL EAW22148.1OrganismNeosartorya fischeri (strain ATCC 1020 / DSM 3700 / FGSC A1164 / NRRL 181) (Aspergillus fischerianus) ARP48167_T100 B7ZR52_XENLA LOC397861 protein Xenopus laevis (African clawed frog) 437 83.00% ORF Names:NFIA_008250 EMBL EAW22148.1OrganismNeosartorya fischeri (strain ATCC 1020 / DSM 3700 / FGSC A1164 / NRRL 181) (Aspergillus Elongation factor 1‐gamma‐B (EF‐1‐gamma‐B) fischerianus) ARP48167_T100 EF1GB_XENLA (eEF‐1B gamma‐B) (p47) Xenopus laevis (African clawed frog) 437 83.00% ORF Names:NFIA_008250 EMBL EAW22148.1OrganismNeosartorya fischeri (strain ATCC 1020 / DSM 3700 / FGSC A1164 / NRRL 181) (Aspergillus Elongation factor 1‐gamma‐A (EF‐1‐gamma‐A) fischerianus) ARP48167_T100 EF1GA_XENLA (eEF‐1B gamma‐A) (p47) Xenopus laevis (African clawed frog) 436 83.00% Fhl3 ARP50498_P050 Q6GP87_XENLA MGC80605 protein Xenopus laevis (African clawed frog) 279 84.00% Xenopus tropicalis (Western clawed frog) Fhl3 ARP50498_P050 Q641J0_XENTR Fhl3 protein (Four and a half LIM domains 3) (Silurana tropicalis) 279 84.00% Xenopus tropicalis (Western clawed frog) Fhl3 ARP50498_P050 B1H0Z6_XENTR LOC100145283 protein (Silurana tropicalis) 279 83.00% Xenopus tropicalis (Western clawed frog) MYLIP ARP43136_P050 B1WAS9_XENTR Putative uncharacterized protein (Silurana tropicalis) 445 85.00% MYLIP ARP43136_P050 Q6GPK0_XENLA MGC83623 protein Xenopus laevis (African clawed frog) 445 78.00% MYLIP ARP43136_P050 Q5XHJ0_XENLA LOC494986 protein Xenopus laevis (African clawed frog) 445 78.00% msi2b ARP41110_P050 Q91920_XENLA Ribonucleoprotein Xenopus laevis (African clawed frog) 406 92.00% msi2b ARP41110_P050 B7ZQK5_XENLA Ribonucleoprotein Xenopus laevis (African clawed frog) 406 92.00% ARP31366_P050 Q5HZP0_XENLA LOC496344 protein Xenopus laevis (African clawed frog) 280 100.00% ARP31366_P050 Q58E78_XENLA MGC85066 protein Xenopus laevis (African clawed frog) 279 100.00% Xenopus tropicalis (Western clawed frog) ARP31366_P050 Q6DJ07_XENTR Activating transcription factor 1 (Silurana tropicalis) 281 100.00% Selenide, water dikinase 1 (EC 2.7.9.3) (Selenium donor protein 1) (Selenophosphate Sephs1 ARP48737_T100 SPS1_XENLA synthase 1) Xenopus laevis (African clawed frog) 392 92.00% Selenide, water dikinase 1 (EC 2.7.9.3) (Selenium donor protein 1) (Selenophosphate Xenopus tropicalis (Western clawed frog) Sephs1 ARP48737_T100 SPS1_XENTR synthase 1) (Silurana tropicalis) 392 92.00% ORF Names:PVX_085010 EMBL EDL46941.1OrganismPlasmodium vivax (strain Salvador I) ARP43059_P050 Q32NH0_XENLA LOC733415 protein (Fragment) Xenopus laevis (African clawed frog) 301 100.00% ORF Names:PVX_085010 EMBL EDL46941.1OrganismPlasmodium vivax STIP1 homology and U‐Box containing protein Xenopus tropicalis (Western clawed frog) (strain Salvador I) ARP43059_P050 Q0V9Q4_XENTR 1 (Silurana tropicalis) 310 100.00% Dhdds ARP48925_P050 Q7ZYJ5_XENLA MGC52912 protein Xenopus laevis (African clawed frog) 332 85.00% Dhdds ARP48925_P050 Q7SYQ1_XENLA LOC398626 protein (Fragment) Xenopus laevis (African clawed frog) 333 85.00% Dhdds ARP48925_P050 Q6IP04_XENLA LOC398626 protein Xenopus laevis (African clawed frog) 332 85.00% LOC100135207 protein (Putative Xenopus tropicalis (Western clawed frog) Dhdds ARP48925_P050 A9ULI1_XENTR uncharacterized protein LOC100135207) (Silurana tropicalis) 332 85.00% fabp7 ARP33827_T100 Q5PPW3_XENLA LOC496060 protein Xenopus laevis (African clawed frog) 132 100.00%

Fatty acid binding protein 7, brain (Putative Xenopus tropicalis (Western clawed frog) fabp7 ARP33827_T100 Q28CE2_XENTR uncharacterized protein LOC548661) (Silurana tropicalis) 132 100.00% fabp7 ARP33827_T100 Q6PGR8_XENLA MGC64521 protein Xenopus laevis (African clawed frog) 131 84.00% fabp7 ARP33827_T100 Q6GPY9_XENLA MGC82505 protein Xenopus laevis (African clawed frog) 131 84.00%

Fatty acid binding protein 3, muscle and heart (Mammary‐derived growth inhibitor) (Fatty Xenopus tropicalis (Western clawed frog) fabp7 ARP33827_T100 Q5EB34_XENTR acid binding protein 7‐b, brain) (Silurana tropicalis) 131 84.00% fabp7 ARP33827_T100 B2L4J2_XENBO Fatty acid bindinG‐protein 7, brain (Fragment) Xenopus borealis (Kenyan clawed frog) 91 84.00%

Fatty acid binding protein 3, muscle and heart Xenopus tropicalis (Western clawed frog) fabp7 ARP33827_T100 A9JSP5_XENTR (Mammary‐derived growth inhibitor) (Silurana tropicalis) 131 84.00% MGC64562 protein (Mitochondrial carrier Mtch2 ARP55027_P050 Q9I905_XENLA homolog 2) Xenopus laevis (African clawed frog) 297 85.00% Xenopus tropicalis (Western clawed frog) Mtch2 ARP55027_P050 Q6P818_XENTR Mitochondrial carrier homolog 2 (Silurana tropicalis) 298 85.00% Xenopus tropicalis (Western clawed frog) Mtch2 ARP55027_P050 Q28I73_XENTR Mitochondrial carrier homolog 2 (C. elegans) (Silurana tropicalis) 298 85.00% DCN1‐like protein 3 (DCUN1 domain‐ containing protein 3) (Defective in cullin Xenopus tropicalis (Western clawed frog) dcun1d3 ARP53231_P050 DCNL3_XENTR neddylation protein 1‐like protein 3) (Silurana tropicalis) 303 100.00% DCN1‐like protein 3 (DCUN1 domain‐ containing protein 3) (Defective in cullin dcun1d3 ARP53231_P050 DCNL3_XENLA neddylation protein 1‐like protein 3) Xenopus laevis (African clawed frog) 303 100.00% Twist gene homolog 1 (Drosophila) (Twist homolog 1) (Twist transcription factor) Xenopus tropicalis (Western clawed frog) ARP37997_T100 Q9PUL7_XENTR (Twist1) (Silurana tropicalis) 166 100.00% ARP37997_T100 A1L2X6_XENLA LOC100036981 protein Xenopus laevis (African clawed frog) 166 100.00% ARP37997_T100 TWIST_XENLA Twist‐related protein (T18) (X‐twist) Xenopus laevis (African clawed frog) 166 100.00% Xenopus tropicalis (Western clawed frog) ARP37997_T100 A7Z097_XENTR Twist3 (Silurana tropicalis) 162 85.00% cbr‐icd‐1 ARP58359_P050 Q5XGK2_XENLA LOC495200 protein Xenopus laevis (African clawed frog) 162 92.00% Xenopus tropicalis (Western clawed frog) cbr‐icd‐1 ARP58359_P050 Q28IY1_XENTR Basic transcription factor 3 (Silurana tropicalis) 209 92.00% Transcription factor BTF3 homolog 4 (Basic Xenopus tropicalis (Western clawed frog) cbr‐icd‐1 ARP58359_P050 BT3L4_XENTR transcription factor 3‐like 4) (Silurana tropicalis) 158 92.00% Transcription factor BTF3 homolog 4 (Basic cbr‐icd‐1 ARP58359_P050 BT3L4_XENLA transcription factor 3‐like 4) Xenopus laevis (African clawed frog) 158 92.00% Myeloid/lymphoid or mixed‐lineage leukemia (Trithorax homolog, Drosophila); translocated Xenopus tropicalis (Western clawed frog) MLLT3 ARP38489_P050 Q28ED2_XENTR to, 3 (Silurana tropicalis) 571 92.00% Xenopus tropicalis (Western clawed frog) MLLT3 ARP38489_P050 Q0IJ28_XENTR Putative uncharacterized protein (Fragment) (Silurana tropicalis) 239 92.00% MLLT3 ARP38489_P050 Q68EY8_XENLA MGC84026 protein Xenopus laevis (African clawed frog) 550 85.00% MLLT3 ARP38489_P050 Q640I2_XENLA LOC494666 protein Xenopus laevis (African clawed frog) 552 85.00% Xenopus tropicalis (Western clawed frog) MLLT3 ARP38489_P050 B2GUE9_XENTR LOC100158574 protein (Silurana tropicalis) 554 85.00% MLLT3 ARP38489_P050 A5PKM5_XENLA Hypothetical LOC494666 Xenopus laevis (African clawed frog) 552 85.00%

ORF Names:MGP2080_03060 EMBL EAW41639.1Organismmarine gamma Glyceraldehyde‐3‐phosphate dehydrogenase proteobacterium HTCC2080 ARP40175_P050 Q8AY70_XENLA type B (Mg:bb02e05‐prov protein) Xenopus laevis (African clawed frog) 333 84.00%

ORF Names:MGP2080_03060 EMBL EAW41639.1Organismmarine gamma proteobacterium HTCC2080 ARP40175_P050 Q7ZY52_XENLA Gapd‐prov protein Xenopus laevis (African clawed frog) 333 84.00%

ORF Names:MGP2080_03060 EMBL Glyceraldehyde‐3‐phosphate dehydrogenase EAW41639.1Organismmarine gamma (GAPDH) (EC 1.2.1.12) (Peptidyl‐cysteine S‐ proteobacterium HTCC2080 ARP40175_P050 G3P_XENLA nitrosylase GAPDH) (EC 2.6.99.‐) Xenopus laevis (African clawed frog) 333 84.00% Iroquois‐class homeodomain protein irx‐1 Xenopus tropicalis (Western clawed frog) irx1b ARP47680_T100 IRX1_XENTR (Iroquois homeobox protein 1) (Silurana tropicalis) 467 100.00% Iroquois‐class homeodomain protein irx‐1‐B irx1b ARP47680_T100 IRX1B_XENLA (Iroquois homeobox protein 1‐B) Xenopus laevis (African clawed frog) 462 100.00% Iroquois‐class homeodomain protein irx‐1‐A (Iroquois homeobox protein 1‐A) (Xiro‐1) irx1b ARP47680_T100 IRX1A_XENLA (Xiro1) Xenopus laevis (African clawed frog) 467 100.00% Xenopus tropicalis (Western clawed frog) irx1b ARP47680_T100 B3DLQ9_XENTR LOC100170530 protein (Silurana tropicalis) 454 85.00% Iroquois‐class homeodomain protein irx‐3 Xenopus tropicalis (Western clawed frog) irx1b ARP47680_T100 IRX3_XENTR (Iroquois homeobox protein 3) (Silurana tropicalis) 448 85.00% Iroquois‐class homeodomain protein irx‐3 irx1b ARP47680_T100 IRX3_XENLA (Iroquois homeobox protein 3) (Xiro3) Xenopus laevis (African clawed frog) 448 85.00% ANXA4 ARP36570_P050 Q90X16_XENLA Annexin 4 (MGC68504 protein) Xenopus laevis (African clawed frog) 321 84.00% ANXA4 ARP36570_P050 Q6GND2_XENLA MGC82879 protein Xenopus laevis (African clawed frog) 321 84.00% Xenopus tropicalis (Western clawed frog) ANXA4 ARP36570_P050 Q28ET2_XENTR Annexin A4 (Silurana tropicalis) 321 84.00% Nuclear receptor subfamily 4 group A member Xenopus tropicalis (Western clawed frog) NR4A2 ARP38753_P050 NR4A2_XENTR 2 (Silurana tropicalis) 591 100.00% Xenopus tropicalis (Western clawed frog) NDST2 ARP49737_P050 B6ID04_XENTR Putative uncharacterized protein (Silurana tropicalis) 879 83.00%

Bifunctional heparan sulfate N‐deacetylase/N‐ sulfotransferase 1 (EC 2.8.2.8) (Glucosaminyl N‐deacetylase/N‐sulfotransferase 1) (NDST‐1) [Includes: Heparan sulfate N‐deacetylase 1 (EC 3.‐.‐.‐); Heparan sulfate N‐sulfotransferase 1 Xenopus tropicalis (Western clawed frog) NDST2 ARP49737_P050 NDST1_XENTR (EC 2.8.2.‐)] (Silurana tropicalis) 878 83.00%

Bifunctional heparan sulfate N‐deacetylase/N‐ sulfotransferase 1 (EC 2.8.2.8) (Glucosaminyl N‐deacetylase/N‐sulfotransferase 1) (NDST‐1) [Includes: Heparan sulfate N‐deacetylase 1 (EC 3.‐.‐.‐); Heparan sulfate N‐sulfotransferase 1 NDST2 ARP49737_P050 NDST1_XENLA (EC 2.8.2.‐)] Xenopus laevis (African clawed frog) 878 83.00% ARP58521_P050 Q9W760_XENLA Small Rho‐like GTPase RhoA Xenopus laevis (African clawed frog) 193 100.00% ARP58521_P050 Q8JHE2_XENLA Small GTPase RhoA Xenopus laevis (African clawed frog) 193 100.00% ARP58521_P050 Q7SZA9_XENLA MGC64296 protein Xenopus laevis (African clawed frog) 193 100.00% Xenopus tropicalis (Western clawed frog) ARP58521_P050 Q6GL96_XENTR Ras homolog gene family, member A (Silurana tropicalis) 112 100.00% Xenopus tropicalis (Western clawed frog) ARP58521_P050 Q28GJ8_XENTR Ras homolog gene family, member A (Silurana tropicalis) 193 100.00% Menage a trois 1 (Menage a trois 1 (CAK Xenopus tropicalis (Western clawed frog) cbr‐mnat‐1 ARP38150_T100 Q28H72_XENTR assembly factor)) (Silurana tropicalis) 309 92.00%

CDK‐activating kinase assembly factor MAT1 (CDK7/cyclin‐H assembly factor) (Menage a cbr‐mnat‐1 ARP38150_T100 MAT1_XENLA trois) (RING finger protein MAT1) Xenopus laevis (African clawed frog) 309 85.00% Xenopus tropicalis (Western clawed frog) Isl1 ARP32336_P050 Q6F2E5_XENTR Isl1 (Fragment) (Silurana tropicalis) 268 100.00% Isl1 ARP32336_P050 Q08B34_XENLA Islet‐1 (LOC100126604 protein) Xenopus laevis (African clawed frog) 354 100.00% Xenopus tropicalis (Western clawed frog) Isl1 ARP32336_P050 B2GTW4_XENTR Isl1 protein (Silurana tropicalis) 335 100.00% ORF Names:Bm1_11280 EMBL EDP37445.1OrganismBrugia malayi (Filarial nematode worm) ARP43025_T100 Q6AZI4_XENLA LOC446231 protein (Fragment) Xenopus laevis (African clawed frog) 153 100.00% ORF Names:Bm1_11280 EMBL EDP37445.1OrganismBrugia malayi Xenopus tropicalis (Western clawed frog) (Filarial nematode worm) ARP43025_T100 Q5BJ50_XENTR Ubiquitin‐conjugating enzyme E2L 3 (Silurana tropicalis) 154 100.00% ORF Names:Bm1_11280 EMBL EDP37445.1OrganismBrugia malayi (Filarial nematode worm) ARP43025_T100 Q4QR35_XENLA LOC446231 protein Xenopus laevis (African clawed frog) 154 100.00% Xenopus tropicalis (Western clawed frog) DAZAP1 ARP40925_P050 Q6DIN9_XENTR DAZ associated protein 1 (Silurana tropicalis) 362 92.00% DAZAP1 ARP40925_P050 Q6AZU2_XENLA LOC398218 protein Xenopus laevis (African clawed frog) 405 92.00% Xenopus tropicalis (Western clawed frog) DAZAP1 ARP40925_P050 Q28EL7_XENTR DAZ associated protein 1 (Silurana tropicalis) 347 92.00%

DAZ‐associated protein 1 (Deleted in azoospermia‐associated protein 1) (Proline‐ DAZAP1 ARP40925_P050 DAZP1_XENLA rich Vg1 mRNA‐binding protein) Xenopus laevis (African clawed frog) 360 92.00% Xenopus tropicalis (Western clawed frog) ADAM33 ARP49937_P050 Q27JK6_XENTR ADAM13 (Silurana tropicalis) 911 84.00% ADAM33 ARP49937_P050 O12960_XENLA ADAM 13 Xenopus laevis (African clawed frog) 914 84.00%

ADAM33 ARP49937_P050 B7ZQX1_XENLA A disintegrin and metalloprotease domain 13 Xenopus laevis (African clawed frog) 914 84.00%

ADAM33 ARP49937_P050 B7ZQW9_XENLA A disintegrin and metalloprotease domain 13 Xenopus laevis (African clawed frog) 914 84.00% LOC100037087 ARP42028_P050 A2BDA9_XENLA LOC100037087 protein Xenopus laevis (African clawed frog) 490 92.00% ORF Names:PHYPADRAFT_125611 EMBL EDQ72728.1OrganismPhyscomitrella Xenopus tropicalis (Western clawed frog) patens subsp. patens (Moss) ARP48177_P050 Q05AR0_XENTR Acetyl‐Coenzyme A acyltransferase 1 (Silurana tropicalis) 419 90.00% PPP2R1A ARP56741_P050 Q92138_XENLA Phosphorylase phosphatase (EC 3.1.3.17) Xenopus laevis (African clawed frog) 589 100.00% PPP2R1A ARP56741_P050 Q7ZWS7_XENLA Ppp2r1a‐prov protein Xenopus laevis (African clawed frog) 589 100.00%

Protein phosphatase 2 (Formerly 2A), regulatory subunit A (PR 65), alpha isoform Xenopus tropicalis (Western clawed frog) PPP2R1A ARP56741_P050 Q6P1U8_XENTR (Putative uncharacterized protein MGC76072) (Silurana tropicalis) 589 100.00% PPP2R1A ARP56741_P050 Q6AZF1_XENLA Ppp2r1a‐b protein Xenopus laevis (African clawed frog) 589 100.00% PPP2R1A ARP56741_P050 Q7ZXU0_XENLA LOC398563 protein (Fragment) Xenopus laevis (African clawed frog) 593 78.00% PPP2R1A ARP56741_P050 Q6GNA3_XENLA LOC398563 protein Xenopus laevis (African clawed frog) 589 78.00% PPP2R1A ARP56741_P050 Q92139_XENLA Phosphorylase phosphatase (EC 3.1.3.17) Xenopus laevis (African clawed frog) 589 78.00% PPP2R1A ARP56741_P050 Q7ZYM9_XENLA Ppp2r1b protein Xenopus laevis (African clawed frog) 589 78.00% Platelet‐derived growth factor beta polypeptide (Simian sarcoma viral (V‐sis) oncogene homolog) (Protein phosphatase 2 (Formerly 2A), regulatory subunit A (PR 65), Xenopus tropicalis (Western clawed frog) PPP2R1A ARP56741_P050 Q6DIG6_XENTR beta isoform) (Silurana tropicalis) 589 78.00% C21orf2 ARP45819_P050 Q68EZ7_XENLA MGC83386 protein Xenopus laevis (African clawed frog) 256 78.00% LOC100049095 ARP40217_P050 A3KMT6_XENLA LOC100049095 protein Xenopus laevis (African clawed frog) 211 100.00% Xenopus tropicalis (Western clawed frog) LOC100049095 ARP40217_P050 Q6P639_XENTR Ribosomal protein L13 (Silurana tropicalis) 211 100.00% LOC100049095 ARP40217_P050 Q8AVQ1_XENLA Similar to ribosomal protein L13 Xenopus laevis (African clawed frog) 211 92.00% LOC100049095 ARP40217_P050 Q6DJN5_XENLA Rpl13‐prov protein Xenopus laevis (African clawed frog) 211 92.00%

ORF Names:GP2143_13946 EMBL EAW32363.1Organismmarine gamma Solute carrier family 17 (Anion/sugar Xenopus tropicalis (Western clawed frog) proteobacterium HTCC2143 ARP43932_P050 Q0V9A2_XENTR transporter), member 5 (Silurana tropicalis) 496 100.00%

ORF Names:GP2143_13946 EMBL EAW32363.1Organismmarine gamma proteobacterium HTCC2143 ARP43932_P050 Q08B61_XENLA LOC100158341 protein Xenopus laevis (African clawed frog) 496 100.00%

ORF Names:DKEY‐103I16.1‐001 EMBL CAQ14750.1OrganismDanio rerio (Zebrafish) (Brachydanio rerio) ARP42133_T100 Q6DCK5_XENLA Ppfibp2‐prov protein Xenopus laevis (African clawed frog) 965 78.00% Xenopus tropicalis (Western clawed frog) TNNI1 ARP42118_T100 A4IH12_XENTR LOC100125108 protein (Silurana tropicalis) 187 100.00% TNNI1 ARP42118_T100 A2VDA1_XENLA LOC100037198 protein Xenopus laevis (African clawed frog) 187 100.00% TNNI1 ARP42118_T100 Q8QGC6_XENLA Fast troponin I (MGC53248 protein) Xenopus laevis (African clawed frog) 182 85.00% Xenopus tropicalis (Western clawed frog) TNNI1 ARP42118_T100 Q5XGD4_XENTR Troponin I type 2 (Skeletal, fast) (Silurana tropicalis) 182 85.00% TNNI1 ARP42118_T100 Q8QGC5_XENLA Slow troponin I Xenopus laevis (African clawed frog) 183 85.00% TNNI1 ARP42118_T100 Q7SYY1_XENLA MGC64405 protein Xenopus laevis (African clawed frog) 183 85.00% Troponin I type 1 (Skeletal, slow) (Troponin I, Xenopus tropicalis (Western clawed frog) TNNI1 ARP42118_T100 Q6P8F9_XENTR skeletal, slow) (Silurana tropicalis) 183 85.00% TNNI1 ARP42118_T100 Q6GNQ7_XENLA MGC80947 protein Xenopus laevis (African clawed frog) 183 85.00% ARP47464_P050 Q6DKC7_XENLA MGC84118 protein Xenopus laevis (African clawed frog) 458 85.00% ARP47464_P050 Q5XGU0_XENLA LOC495266 protein Xenopus laevis (African clawed frog) 452 85.00% aldh4a1 ARP45697_T100 A0AUU7_XENLA Aldh4a1 protein Xenopus laevis (African clawed frog) 555 92.00% Xenopus tropicalis (Western clawed frog) aldh4a1 ARP45697_T100 A4QNJ0_XENTR Aldh4a1 protein (Silurana tropicalis) 556 92.00% PMGE ARP58218_P050 Q6GPF4_XENLA MGC80400 protein Xenopus laevis (African clawed frog) 259 90.00%

2,3‐bisphosphoglycerate mutase (Putative Xenopus tropicalis (Western clawed frog) PMGE ARP58218_P050 Q28I68_XENTR uncharacterized protein LOC549353) (Silurana tropicalis) 259 90.00% Xenopus tropicalis (Western clawed frog) eps8l1 ARP42492_P050 B2GU30_XENTR LOC100158498 protein (Silurana tropicalis) 522 92.00% ARP40810_T100 E3WDQ9_XENLA Pumilio2 Xenopus laevis (African clawed frog) 1173 78.00% NFE2L2 ARP38745_T100 Q7ZTP1_XENLA MGC53355 protein Xenopus laevis (African clawed frog) 591 84.00% NFE2L2 ARP38745_T100 Q640J4_XENLA MGC53355 protein Xenopus laevis (African clawed frog) 591 84.00% NFE2L2 ARP38745_T100 Q6GLL4_XENLA MGC84750 protein Xenopus laevis (African clawed frog) 591 84.00% Nuclear factor (Erythroid‐derived 2)‐like 2 (Similar to (Nuclear factor (Erythroid‐ Xenopus tropicalis (Western clawed frog) NFE2L2 ARP38745_T100 Q68FB5_XENTR derived 2)‐like 2)) (Silurana tropicalis) 589 76.00% ZFHX1B ARP39141_P050 Q9IB60_XENLA Smad interaction protein 1 Xenopus laevis (African clawed frog) 1214 92.00% ZFHX1B ARP39141_P050 Q9I8P1_XENLA Smad‐interacting protein 1 Xenopus laevis (African clawed frog) 1213 92.00% ZFHX1B ARP39141_P050 Q5U4S2_XENLA Sip1 protein Xenopus laevis (African clawed frog) 1214 92.00% Xenopus tropicalis (Western clawed frog) EFTU ARP58546_P050 Q6P2W6_XENTR Tubb4 protein (Fragment) (Silurana tropicalis) 451 100.00% Appbp2 ARP52171_P050 Q6DCT9_XENLA Appbp2‐prov protein Xenopus laevis (African clawed frog) 585 76.00%

ORF Names:AGAP007207OrganismAnophel Xenopus tropicalis (Western clawed frog) es gambiae (African malaria mosquito) ARP49350_P050 Q0D2E1_XENTR Protocadherin 10 (Silurana tropicalis) 1009 100.00%

ORF Names:AGAP007207OrganismAnophel es gambiae (African malaria mosquito) ARP49350_P050 Q6PF44_XENLA LOC398725 protein (Fragment) Xenopus laevis (African clawed frog) 928 100.00% V‐type proton ATPase 116 kDa subunit a isoform 1 (V‐ATPase 116 kDa isoform a1) (Vacuolar proton translocating ATPase 116 Xenopus tropicalis (Western clawed frog) atp6v0a1 ARP46581_P050 VPP1_XENTR kDa subunit a isoform 1) (Silurana tropicalis) 837 100.00% V‐type proton ATPase 116 kDa subunit a isoform 1 (V‐ATPase 116 kDa isoform a1) (Vacuolar proton translocating ATPase 116 atp6v0a1 ARP46581_P050 VPP1_XENLA kDa subunit a isoform 1) Xenopus laevis (African clawed frog) 831 100.00% ATPase, H+ transporting, lysosomal V0 subunit Xenopus tropicalis (Western clawed frog) atp6v0a1 ARP46581_P050 Q28CM5_XENTR a isoform 2 (Silurana tropicalis) 845 78.00% ATPase, H+ transporting, lysosomal V0 subunit Xenopus tropicalis (Western clawed frog) atp6v0a1 ARP46581_P050 B7ZTU5_XENTR a2 (Silurana tropicalis) 845 78.00% Xenopus tropicalis (Western clawed frog) atp6v0a1 ARP46581_P050 B2GTY9_XENTR Atp6v0a2 protein (Silurana tropicalis) 787 78.00% G6pd2 ARP58469_P050 Q6PCH4_XENLA MGC69058 protein Xenopus laevis (African clawed frog) 518 76.00% Xenopus tropicalis (Western clawed frog) G6pd2 ARP58469_P050 Q5BKM9_XENTR Glucose‐6‐phosphate dehydrogenase 2 (Silurana tropicalis) 500 76.00% Xenopus tropicalis (Western clawed frog) G6pd2 ARP58469_P050 Q28DI9_XENTR Glucose‐6‐phosphate dehydrogenase (Silurana tropicalis) 518 76.00% Lateral signaling target protein 2 homolog (Zinc finger FYVE domain‐containing protein Xenopus tropicalis (Western clawed frog) zfyve28 ARP50654_P050 LST2_XENTR 28) (Silurana tropicalis) 951 92.00% Tekt2 ARP53697_P050 Q3B8J4_XENLA MGC130819 protein Xenopus laevis (African clawed frog) 430 92.00% Xenopus tropicalis (Western clawed frog) Tekt2 ARP53697_P050 Q68EP8_XENTR Tekt2 protein (Tektin 2 (Testicular)) (Silurana tropicalis) 430 85.00% Tekt2 ARP53697_P050 Q7ZTQ3_XENLA MGC52862 protein Xenopus laevis (African clawed frog) 430 85.00% tmed8 ARP56016_P050 Q3KQ03_XENLA MGC131158 protein Xenopus laevis (African clawed frog) 231 85.00% Xenopus tropicalis (Western clawed frog) tmed8 ARP56016_P050 B0BMH9_XENTR LOC100145041 protein (Silurana tropicalis) 231 85.00% Serine threonine kinase 39 (STE20/SPS1 Xenopus tropicalis (Western clawed frog) oxsr1a ARP48745_P050 Q6NVS1_XENTR homolog) (Silurana tropicalis) 526 92.00% oxsr1a ARP48745_P050 Q6DD77_XENLA Stk39‐prov protein Xenopus laevis (African clawed frog) 527 92.00% oxsr1a ARP48745_P050 Q6DD36_XENLA Osr1‐prov protein Xenopus laevis (African clawed frog) 528 92.00% oxsr1a ARP48745_P050 A0JPG0_XENLA Stk39 protein Xenopus laevis (African clawed frog) 528 92.00% Xenopus tropicalis (Western clawed frog) ARP56404_P050 Q6DJ99_XENTR Pinin, desmosome associated protein (Silurana tropicalis) 691 78.00% ARP56404_P050 Q52KX2_XENLA Sdk2‐a protein Xenopus laevis (African clawed frog) 689 78.00% ARP56404_P050 O73620_XENLA Nuclear protein SDK2 Xenopus laevis (African clawed frog) 689 78.00% ORF Names:ACLA_079750 EMBL EAW06291.1OrganismAspergillus Xenopus tropicalis (Western clawed frog) clavatus ARP52802_P050 Q0VFI1_XENTR DIRAS family, GTP‐binding RAS‐like 1 (Silurana tropicalis) 198 100.00% ORF Names:ACLA_079750 EMBL EAW06291.1OrganismAspergillus clavatus ARP52802_P050 Q5PQ55_XENLA LOC495976 protein Xenopus laevis (African clawed frog) 198 92.00% ORF Names:ACLA_079750 EMBL EAW06291.1OrganismAspergillus DIRAS family, GTP‐binding RAS‐like 3 (Diras3 Xenopus tropicalis (Western clawed frog) clavatus ARP52802_P050 A9ULF5_XENTR protein) (Silurana tropicalis) 198 92.00% ORF Names:ACLA_079750 EMBL EAW06291.1OrganismAspergillus clavatus ARP52802_P050 Q6GM41_XENLA MGC83985 protein Xenopus laevis (African clawed frog) 199 85.00% PTPN2 ARP45362_T100 Q6DD82_XENLA Ptpn2‐prov protein Xenopus laevis (African clawed frog) 468 92.00% PTPN2 ARP45362_T100 Q6NRX9_XENLA MGC81077 protein Xenopus laevis (African clawed frog) 462 85.00% PTPN2 ARP45362_T100 Q6GMA0_XENLA MGC81984 protein Xenopus laevis (African clawed frog) 428 78.00% Xenopus tropicalis (Western clawed frog) PTPN2 ARP45362_T100 B1H2K9_XENTR Putative uncharacterized protein (Silurana tropicalis) 433 78.00% Xenopus tropicalis (Western clawed frog) ARP58149_P050 MAFB_XENTR Transcription factor MafB (Maf‐B) (XMafB) (Silurana tropicalis) 316 92.00%

ARP58149_P050 MAFB_XENLA Transcription factor MafB (Maf‐B) (XMafB) Xenopus laevis (African clawed frog) 313 92.00% ORF Names:An01g05390 EMBL CAK43708.1OrganismAspergillus niger P33ING1b variant 1 (P33ING1b variant 2) (strain CBS 513.88 / FGSC A1513) ARP50512_T100 Q3L6P2_XENLA (P33ING1b variant 3) (P33ING1b variant 4) Xenopus laevis (African clawed frog) 279 100.00%

ORF Names:An01g05390 EMBL CAK43708.1OrganismAspergillus niger (strain CBS 513.88 / FGSC A1513) ARP50512_T100 Q3L6N9_XENLA P33ING1b variant 5 Xenopus laevis (African clawed frog) 279 100.00%

ORF Names:An01g05390 EMBL CAK43708.1OrganismAspergillus niger (strain CBS 513.88 / FGSC A1513) ARP50512_T100 Q3L6N7_XENLA P21ING1c variant 1 (P21ING1c variant 2) Xenopus laevis (African clawed frog) 185 100.00%

ORF Names:An01g05390 EMBL CAK43708.1OrganismAspergillus niger Xenopus tropicalis (Western clawed frog) (strain CBS 513.88 / FGSC A1513) ARP50512_T100 A4IGN5_XENTR Ing1 protein (Silurana tropicalis) 279 100.00% Xenopus tropicalis (Western clawed frog) Kptn ARP58488_P050 B5DDX1_XENTR Putative uncharacterized protein (Silurana tropicalis) 145 76.00% Kptn ARP58488_P050 Q6INK4_XENLA MGC82410 protein Xenopus laevis (African clawed frog) 431 76.00% ORF Names:GSPATT00008921001 EMBL CAK72479.1OrganismParamecium tetraurelia ARP39412_P050 Q32N94_XENLA Putative uncharacterized protein (Fragment) Xenopus laevis (African clawed frog) 522 84.00% ORF Names:GSPATT00008921001 EMBL CAK72479.1OrganismParamecium tetraurelia ARP39412_P050 A6H8I9_XENLA Acbd3 protein Xenopus laevis (African clawed frog) 514 76.00% ORF Names:GSPATT00008921001 EMBL CAK72479.1OrganismParamecium Xenopus tropicalis (Western clawed frog) tetraurelia ARP39412_P050 A4QNP1_XENTR Acbd3 protein (Silurana tropicalis) 518 76.00% pcbp1 ARP40567_T100 Q9W702_XENLA HnRNP‐E2 protein Xenopus laevis (African clawed frog) 353 100.00% pcbp1 ARP40567_T100 Q8AVV9_XENLA Pcbp2b protein Xenopus laevis (African clawed frog) 353 100.00% pcbp1 ARP40567_T100 Q7M556_XENLA HnRNP‐E2 b Xenopus laevis (African clawed frog) 319 100.00% pcbp1 ARP40567_T100 Q6GLW4_XENLA MGC84166 protein Xenopus laevis (African clawed frog) 225 100.00%

Novel protein similar to poly(RC) binding Xenopus tropicalis (Western clawed frog) pcbp1 ARP40567_T100 Q6GLD4_XENTR protein 2 (Poly(RC) binding protein 2) (Silurana tropicalis) 353 100.00% pcbp1 ARP40567_T100 Q5XH78_XENLA Pcbp2 protein Xenopus laevis (African clawed frog) 353 100.00% pcbp1 ARP40567_T100 A2RV79_XENLA LOC100037147 protein Xenopus laevis (African clawed frog) 221 100.00% Xenopus tropicalis (Western clawed frog) pcbp1 ARP40567_T100 A4IH01_XENTR LOC733863 protein (Silurana tropicalis) 475 100.00% Xenopus tropicalis (Western clawed frog) Mif4gd ARP40949_P050 MI4GD_XENTR MIF4G domain‐containing protein (Silurana tropicalis) 223 76.00% St3gal3 ARP46706_P050 Q70D55_XENLA Alpha2,3‐sialyltransferase (EC 2.4.99.6) Xenopus laevis (African clawed frog) 360 92.00% Xenopus tropicalis (Western clawed frog) St3gal3 ARP46706_P050 Q702R6_XENTR Alpha‐2,3‐sialyltransferase ST3Gal III (Silurana tropicalis) 358 92.00% Xenopus tropicalis (Western clawed frog) St3gal3 ARP46706_P050 Q0P4X4_XENTR St3gal3 protein (Silurana tropicalis) 415 92.00% St3gal3 ARP46706_P050 B7ZQA7_XENLA St3Gal‐III protein Xenopus laevis (African clawed frog) 360 92.00% Xenopus tropicalis (Western clawed frog) St3gal3 ARP46706_P050 A4IGP6_XENTR Siat6 protein (Silurana tropicalis) 374 92.00%

ORF Names:v1g101727OrganismNematostel la vectensis (Starlet sea anemone) ARP51973_P050 Q7T0N5_XENLA Chn1‐prov protein Xenopus laevis (African clawed frog) 459 92.00%

ORF Names:v1g101727OrganismNematostel Xenopus tropicalis (Western clawed frog) la vectensis (Starlet sea anemone) ARP51973_P050 B1H2N7_XENTR Chn1 protein (Silurana tropicalis) 334 92.00%

ORF Names:v1g101727OrganismNematostel la vectensis (Starlet sea anemone) ARP51973_P050 Q6GNI5_XENLA MGC82782 protein Xenopus laevis (African clawed frog) 332 84.00% Thyroid hormone receptor‐associated protein ORF Names:RCJMB04_1m9 EMBL 3 (Thyroid hormone receptor‐associated CAG31039.1OrganismGallus gallus protein complex 150 kDa component) (Chicken) ARP50964_P050 TR150_XENLA (Trap150) Xenopus laevis (African clawed frog) 951 92.00%

ORF Names:POSPLDRAFT_63635 EMBL Eukaryotic translation initiation factor 2 EED78029.1OrganismPostia placenta subunit 1 (Eukaryotic translation initiation (strain ATCC 44394 / Madison 698‐R) factor 2 subunit alpha) (eIF‐2‐alpha) (eIF‐2A) Xenopus tropicalis (Western clawed frog) (Brown rot fungus) (Poria monticola) ARP40508_T100 IF2A_XENTR (eIF‐2alpha) (Silurana tropicalis) 315 100.00%

ORF Names:POSPLDRAFT_63635 EMBL Eukaryotic translation initiation factor 2 EED78029.1OrganismPostia placenta subunit 1 (Eukaryotic translation initiation (strain ATCC 44394 / Madison 698‐R) factor 2 subunit alpha) (eIF‐2‐alpha) (eIF‐2A) (Brown rot fungus) (Poria monticola) ARP40508_T100 IF2A_XENLA (eIF‐2alpha) Xenopus laevis (African clawed frog) 315 92.00% ORF Names:CpipJ_CPIJ004963 EMBL EDS44155.1OrganismCulex quinquefasciatus (Southern house Xenopus tropicalis (Western clawed frog) mosquito) (Culex pungens) ARP39401_P050 Q28BY3_XENTR PR domain containing 8 (Silurana tropicalis) 589 100.00% Xenopus tropicalis (Western clawed frog) ARP39942_T100 Q28BY3_XENTR PR domain containing 8 (Silurana tropicalis) 589 100.00% ARP40417_P050 Q68A88_XENLA 20S proteasome alpha6 subunit (Fragment) Xenopus laevis (African clawed frog) 261 100.00% Xenopus tropicalis (Western clawed frog) ARP40417_P050 Q642N1_XENTR MGC90008 protein (Silurana tropicalis) 261 100.00% ARP40417_P050 Q5XGP0_XENLA Putative uncharacterized protein Xenopus laevis (African clawed frog) 261 100.00% ARP40417_P050 Q58E21_XENLA MGC115143 protein Xenopus laevis (African clawed frog) 261 100.00% Proteasome (Prosome macropain) subunit Xenopus tropicalis (Western clawed frog) ARP40417_P050 Q28FS5_XENTR alpha type 1 (Silurana tropicalis) 261 100.00% Xenopus tropicalis (Western clawed frog) ARP41483_P050 Q6P869_XENTR Desmin (Desmin, gene 1) (Silurana tropicalis) 458 92.00% ARP41483_P050 Q6AZI8_XENLA Des‐prov protein Xenopus laevis (African clawed frog) 458 92.00% ARP41483_P050 DESM_XENLA Desmin Xenopus laevis (African clawed frog) 458 92.00% ARP48156_P050 Q7ZYR1_XENLA Rpl3‐prov protein Xenopus laevis (African clawed frog) 403 100.00% Xenopus tropicalis (Western clawed frog) ARP48156_P050 B0BM43_XENTR LOC100145083 protein (Silurana tropicalis) 403 100.00% ARP48156_P050 Q68ES9_XENLA MGC84749 protein Xenopus laevis (African clawed frog) 420 85.00%

ARP38858_T100 Q91860_XENLA TFIIS elongation factor (XTFIIS.oB protein) Xenopus laevis (African clawed frog) 303 85.00% LOC594866 protein (TFIIS elongation factor) ARP38858_T100 Q91980_XENLA (Transcriptional factor) Xenopus laevis (African clawed frog) 303 78.00% ARP38858_T100 Q90ZI7_XENLA TFIIS (Fragment) Xenopus laevis (African clawed frog) 24 78.00%

Putative uncharacterized protein MGC76031 Xenopus tropicalis (Western clawed frog) ARP38858_T100 Q6PBC6_XENTR (Transcription elongation factor A (SII), 1) (Silurana tropicalis) 304 83.00% LOC398066 protein (Transcription elongation ARP38858_T100 Q91692_XENLA factor type xTFIIS.l) Xenopus laevis (African clawed frog) 292 78.00% Xenopus tropicalis (Western clawed frog) NIPS2 ARP48170_P050 Q28CB8_XENTR Glioblastoma amplified sequence (Silurana tropicalis) 282 78.00%

Fibcd1 ARP50135_P050 FBCDA_XENLA Fibrinogen C domain‐containing protein 1‐A Xenopus laevis (African clawed frog) 457 84.00% Xenopus tropicalis (Western clawed frog) Fibcd1 ARP50135_P050 FBCD1_XENTR Fibrinogen C domain‐containing protein 1 (Silurana tropicalis) 457 84.00%

Fibcd1 ARP50135_P050 FBCDB_XENLA Fibrinogen C domain‐containing protein 1‐B Xenopus laevis (African clawed frog) 457 84.00% Xenopus tropicalis (Western clawed frog) echdc1 ARP48841_P050 Q5M791_XENTR LOC496886 protein (Fragment) (Silurana tropicalis) 287 84.00% echdc1 ARP48841_P050 Q5HZQ8_XENLA LOC496330 protein Xenopus laevis (African clawed frog) 299 84.00% Enoyl Coenzyme A hydratase domain Xenopus tropicalis (Western clawed frog) echdc1 ARP48841_P050 Q28C91_XENTR containing 1 (Silurana tropicalis) 299 84.00% Xenopus tropicalis (Western clawed frog) echdc1 ARP48841_P050 Q0VFD0_XENTR LOC496886 protein (Fragment) (Silurana tropicalis) 293 84.00% GOLPH2 ARP47269_P050 Q641D4_XENLA MGC82000 protein Xenopus laevis (African clawed frog) 355 100.00% Xenopus tropicalis (Western clawed frog) GOLPH2 ARP47269_P050 Q0VA43_XENTR LOC779448 protein (Fragment) (Silurana tropicalis) 435 100.00%

Transcriptional activator protein Pur‐beta‐B purb ARP41073_P050 PURBB_XENLA (Purine‐rich element‐binding protein B‐B) Xenopus laevis (African clawed frog) 328 100.00% Xenopus tropicalis (Western clawed frog) neuA ARP48845_P050 Q0E672_XENTR Putative CMP‐sialic acid synthetase (Silurana tropicalis) 402 100.00% Tollip ARP31758_P050 TOIPA_XENLA Toll‐interacting protein A Xenopus laevis (African clawed frog) 269 91.00% Xenopus tropicalis (Western clawed frog) Tollip ARP31758_P050 TOLIP_XENTR Toll‐interacting protein (Silurana tropicalis) 269 83.00% Tollip ARP31758_P050 TOIPB_XENLA Toll‐interacting protein B Xenopus laevis (African clawed frog) 269 83.00% TRIB2 ARP55377_P050 Q76D16_XENLA Serine/threonine protein kinase Xenopus laevis (African clawed frog) 342 100.00% Putative uncharacterized protein TRIB2 ARP55377_P050 Q76D13_XENLA (Serine/threonine protein kinase) Xenopus laevis (African clawed frog) 343 100.00% TRIB2 ARP55377_P050 Q76D11_XENLA Serine/threonine protein kinase Xenopus laevis (African clawed frog) 207 100.00% Xenopus tropicalis (Western clawed frog) TRIB2 ARP55377_P050 Q76D10_XENTR Serine/threonine protein kinase (Fragment) (Silurana tropicalis) 240 100.00% Xenopus tropicalis (Western clawed frog) TRIB2 ARP55377_P050 Q76D09_XENTR Serine/threonine protein kinase (Silurana tropicalis) 343 100.00% Serine/threonine protein kinase (Tribbles Xenopus tropicalis (Western clawed frog) TRIB2 ARP55377_P050 Q76D08_XENTR homolog 2) (Silurana tropicalis) 343 100.00% Xenopus tropicalis (Western clawed frog) TRIB2 ARP55377_P050 Q76D07_XENTR Serine/threonine protein kinase (Silurana tropicalis) 342 100.00% Xenopus tropicalis (Western clawed frog) TRIB2 ARP55377_P050 Q76D06_XENTR Serine/threonine protein kinase (Fragment) (Silurana tropicalis) 208 100.00% TRIB2 ARP55377_P050 Q7ZZZ7_XENLA TRB‐2 kinase Xenopus laevis (African clawed frog) 344 91.00% Prkaca ARP56416_P050 Q7ZWV0_XENLA Kin‐1‐prov protein Xenopus laevis (African clawed frog) 351 92.00%

CAMP‐dependent protein kinase catalytic subunit alpha (cAMP‐dependent protein Prkaca ARP56416_P050 Q90WN3_XENLA kinase catalytic subunit alpha) Xenopus laevis (African clawed frog) 351 92.00% CAMP‐dependent protein kinase catalytic Prkaca ARP56416_P050 Q90WN2_XENLA subunit beta (Fragment) Xenopus laevis (African clawed frog) 349 92.00% Prkaca ARP56416_P050 Q6DE61_XENLA Prkacb‐prov protein Xenopus laevis (African clawed frog) 351 92.00% Protein kinase, cAMP dependent, catalytic, alpha (Protein kinase, cAMP‐dependent, Xenopus tropicalis (Western clawed frog) Prkaca ARP56416_P050 Q28GZ8_XENTR catalytic, alpha) (Silurana tropicalis) 351 92.00% Xenopus tropicalis (Western clawed frog) slc25a45 ARP43809_T100 A8WH25_XENTR LOC100127755 protein (Silurana tropicalis) 290 84.00% Xenopus tropicalis (Western clawed frog) ARP36669_T100 Q0V9Q6_XENTR Minichromosome maintenance protein 8 (Silurana tropicalis) 843 91.00% Xenopus tropicalis (Western clawed frog) ARP36669_T100 A4IIB8_XENTR MGC146393 protein (Silurana tropicalis) 675 91.00% Asb6 ARP53352_P050 Q6P7G4_XENLA MGC68811 protein Xenopus laevis (African clawed frog) 424 83.00% Asb6 ARP53352_P050 Q6DJD7_XENLA MGC84459 protein Xenopus laevis (African clawed frog) 426 83.00% Xenopus tropicalis (Western clawed frog) Asb6 ARP53352_P050 Q28GR9_XENTR Ankyrin repeat and SOCS box‐containing 6 (Silurana tropicalis) 426 83.00% Wt1 ARP37989_P050 WT1A_XENLA Isoform 2 Xenopus laevis (African clawed frog) 411 100.00% Xenopus tropicalis (Western clawed frog) Wt1 ARP37989_P050 WT1_XENTR Wilms tumor protein homolog (Silurana tropicalis) 413 100.00% Wilms tumor protein homolog B (XWT1b) Wt1 ARP37989_P050 WT1B_XENLA (XeWT1) Xenopus laevis (African clawed frog) 407 100.00% Wilms tumor protein homolog A (XWT1a) Wt1 ARP37989_P050 WT1A_XENLA (xWT1) Xenopus laevis (African clawed frog) 414 100.00% UBR7 ARP43242_T100 Q7ZX39_XENLA LOC398523 protein (Fragment) Xenopus laevis (African clawed frog) 433 78.00% UBR7 ARP43242_T100 Q6INJ1_XENLA LOC398523 protein (Fragment) Xenopus laevis (African clawed frog) 438 78.00% UBR7 ARP43242_T100 Q641C0_XENLA LOC446971 protein (Fragment) Xenopus laevis (African clawed frog) 448 78.00%

UBR7 ARP43242_T100 Q569T8_XENLA Putative uncharacterized protein (Fragment) Xenopus laevis (African clawed frog) 442 78.00% UBR7 ARP43242_T100 Q505M6_XENLA LOC446971 protein (Fragment) Xenopus laevis (African clawed frog) 435 78.00% UBR7 ARP43242_T100 Q2TAW1_XENLA LOC446971 protein Xenopus laevis (African clawed frog) 459 78.00%

UBR7 ARP43242_T100 Q2TAU8_XENLA Putative uncharacterized protein (Fragment) Xenopus laevis (African clawed frog) 443 78.00% Xenopus tropicalis (Western clawed frog) glt8d1 ARP44608_P050 B7ZTW3_XENTR Glycosyltransferase 8 domain containing 1 (Silurana tropicalis) 371 92.00% Glycosyltransferase 8 domain‐containing Xenopus tropicalis (Western clawed frog) glt8d1 ARP44608_P050 GL8D1_XENTR protein 1 (EC 2.4.1.‐) (Silurana tropicalis) 371 92.00% Xenopus tropicalis (Western clawed frog) glt8d1 ARP44608_P050 B1H115_XENTR Glycosyltransferase 8 domain containing 1 (Silurana tropicalis) 371 92.00% Glycosyltransferase 8 domain‐containing glt8d1 ARP44608_P050 GL8D1_XENLA protein 1 (EC 2.4.1.‐) Xenopus laevis (African clawed frog) 364 92.00% ARP42384_T100 Q6P422_XENLA MGC68735 protein Xenopus laevis (African clawed frog) 446 78.00% Xenopus tropicalis (Western clawed frog) ARP42384_T100 B1H179_XENTR LOC100145314 protein (Silurana tropicalis) 429 78.00%

Fatty acid desaturase 2 (EC 1.14.19.‐) (Delta(6) fatty acid desaturase) (D6D) (Delta(6) ARP42384_T100 FADS2_XENLA desaturase) (Delta‐6 desaturase) Xenopus laevis (African clawed frog) 446 78.00% ZNF287 ARP38775_P050 Q6DDD7_XENLA Znf16 protein Xenopus laevis (African clawed frog) 460 90.00% Xenopus tropicalis (Western clawed frog) ZNF287 ARP38775_P050 Q28CS9_XENTR Novel zinc finger protein (Silurana tropicalis) 583 90.00% Xenopus tropicalis (Western clawed frog) ZNF287 ARP38775_P050 B3DLT7_XENTR Putative uncharacterized protein (Silurana tropicalis) 403 90.00% Stat5a ARP39000_P050 Q90Z15_XENLA STAT5 Xenopus laevis (African clawed frog) 780 85.00% Stat5a ARP39000_P050 Q6NU32_XENLA MGC81286 protein Xenopus laevis (African clawed frog) 781 85.00% Stat5a ARP39000_P050 B7ZRD3_XENLA Stat5a protein Xenopus laevis (African clawed frog) 781 85.00% Xenopus tropicalis (Western clawed frog) ARP54631_P050 Q6P3M7_XENTR Putative uncharacterized protein MGC76300 (Silurana tropicalis) 355 85.00% ARP54631_P050 Q5U4X0_XENLA Gnai3 protein Xenopus laevis (African clawed frog) 355 85.00% Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide Xenopus tropicalis (Western clawed frog) ARP54631_P050 Q5I080_XENTR 3 (Silurana tropicalis) 354 85.00% Xenopus tropicalis (Western clawed frog) ARP54631_P050 A4IGY7_XENTR LOC100038283 protein (Silurana tropicalis) 354 85.00% Guanine nucleotide‐binding protein G(i) subunit alpha‐1 (Adenylate cyclase‐inhibiting ARP54631_P050 GNAI1_XENLA G alpha protein) Xenopus laevis (African clawed frog) 354 85.00% Guanine nucleotide‐binding protein Gi alpha ARP54631_P050 O93565_XENLA subunit (Fragment) Xenopus laevis (African clawed frog) 350 85.00% ARP54631_P050 Q7ZXT7_XENLA MGC53612 protein Xenopus laevis (African clawed frog) 354 85.00%

Guanine nucleotide‐binding protein G(k) ARP54631_P050 GNAI3_XENLA subunit alpha (G(i) alpha‐3) (Fragment) Xenopus laevis (African clawed frog) 345 85.00% Xenopus tropicalis (Western clawed frog) exoc3 ARP52317_P050 Q6DJR6_XENTR SEC6‐like 1 (S. cerevisiae) (Silurana tropicalis) 747 92.00% GTF2E1 P100863_P050 Q91859_XENLA Transcription factor IIE Xenopus laevis (African clawed frog) 433 100.00% GTF2E1 P100863_P050 Q7ZTQ1_XENLA Tfiiealpha protein Xenopus laevis (African clawed frog) 263 100.00% General transcription factor IIE, polypeptide 1, Xenopus tropicalis (Western clawed frog) GTF2E1 P100863_P050 Q6DFT2_XENTR alpha 56kDa (Silurana tropicalis) 435 100.00% General transcription factor IIE, polypeptide 1, Xenopus tropicalis (Western clawed frog) GTF2E1 P100863_P050 Q28GU2_XENTR alpha 56kDa (Fragment) (Silurana tropicalis) 325 100.00% General transcription factor IIE, polypeptide 1, Xenopus tropicalis (Western clawed frog) GTF2E1 P100863_P050 Q0P4H8_XENTR alpha 56kDa, gene 2 (Silurana tropicalis) 421 84.00% COX18 ARP55716_P050 Q3B8F3_XENLA MGC131222 protein Xenopus laevis (African clawed frog) 381 78.00% Xenopus tropicalis (Western clawed frog) COX18 ARP55716_P050 B7ZU56_XENTR Putative uncharacterized protein LOC549087 (Silurana tropicalis) 381 78.00% ORF Names:GSPATT00025469001 EMBL CAK92735.1OrganismParamecium tetraurelia ARP55257_P050 DPCD_XENLA Protein DPCD Xenopus laevis (African clawed frog) 203 92.00% ORF Names:GSPATT00025469001 EMBL CAK92735.1OrganismParamecium Xenopus tropicalis (Western clawed frog) tetraurelia ARP55257_P050 DPCD_XENTR Protein DPCD (Silurana tropicalis) 203 85.00% ARP47601_P050 Q7ZXR5_XENLA Pa2g4 protein (Fragment) Xenopus laevis (African clawed frog) 395 100.00% ARP47601_P050 Q6GNV0_XENLA MGC80858 protein Xenopus laevis (African clawed frog) 390 100.00% ARP47601_P050 Q5U5C4_XENLA Pa2g4 protein Xenopus laevis (African clawed frog) 390 100.00% Xenopus tropicalis (Western clawed frog) ARP47601_P050 Q66KL8_XENTR MGC79578 protein (Silurana tropicalis) 390 92.00% Xenopus tropicalis (Western clawed frog) ARP47601_P050 Q28FX5_XENTR Proliferation‐associated 2G4 (Fragment) (Silurana tropicalis) 367 92.00% ORF Names:GSPATT00005247001 EMBL CAK60497.1OrganismParamecium tetraurelia ARP51990_P050 Q6INV5_XENLA Ck2a1 protein Xenopus laevis (African clawed frog) 401 100.00% ORF Names:GSPATT00005247001 EMBL CAK60497.1OrganismParamecium Casein kinase II subunit alpha (CK II) (EC tetraurelia ARP51990_P050 CSK21_XENLA 2.7.11.1) Xenopus laevis (African clawed frog) 392 100.00% ORF Names:GSPATT00005247001 EMBL CAK60497.1OrganismParamecium tetraurelia ARP51990_P050 Q6INF7_XENLA MGC83125 protein Xenopus laevis (African clawed frog) 349 92.00% Ordered Locus Names:CFF8240_1820OrganismCampyl obacter fetus subsp. fetus (strain 82‐ Xenopus tropicalis (Western clawed frog) 40) ARP37839_P050 B4F6T5_XENTR Putative uncharacterized protein (Silurana tropicalis) 426 85.00% Xenopus tropicalis (Western clawed frog) unc5a ARP50294_P050 A4III2_XENTR Unc5a protein (Silurana tropicalis) 895 85.00%

ORF UDP‐N‐acetyl‐alpha‐D‐ Names:v1g141560OrganismNematostel galactosamine:polypeptide N‐ Xenopus tropicalis (Western clawed frog) la vectensis (Starlet sea anemone) ARP49834_P050 Q0V9M3_XENTR acetylgalactosaminyltransferase 14 (Silurana tropicalis) 555 92.00%

ORF UDP‐N‐acetyl‐alpha‐D‐ Names:v1g141560OrganismNematostel galactosamine:polypeptide N‐ Xenopus tropicalis (Western clawed frog) la vectensis (Starlet sea anemone) ARP49834_P050 Q28CC6_XENTR acetylgalactosaminyltransferase‐like 1 (Silurana tropicalis) 562 84.00%

ORF Names:v1g141560OrganismNematostel la vectensis (Starlet sea anemone) ARP49834_P050 A5PKR1_XENLA LOC100101309 protein Xenopus laevis (African clawed frog) 563 84.00% ARP38696_P050 Q6GNN3_XENLA MGC80986 protein Xenopus laevis (African clawed frog) 429 78.00% ARP38696_P050 C0J6M9_XENLA MEF2A alpha 1b isoform Xenopus laevis (African clawed frog) 406 78.00% ARP38696_P050 C0J6M8_XENLA MEF2A alpha 1c isoform Xenopus laevis (African clawed frog) 142 78.00% ARP38696_P050 C0J6M7_XENLA MEF2A MADS box isoform Xenopus laevis (African clawed frog) 67 78.00% ARP38696_P050 C0J6M6_XENLA MEF2A alpha 2 isoform Xenopus laevis (African clawed frog) 477 78.00% ARP38696_P050 C0J6M5_XENLA MEF2A alpha 12b isoform Xenopus laevis (African clawed frog) 448 78.00% Xenopus tropicalis (Western clawed frog) ARP38696_P050 B4F6K5_XENTR Putative uncharacterized protein (Silurana tropicalis) 219 78.00% Xenopus tropicalis (Western clawed frog) ARP38696_P050 A9JTN7_XENTR Mef2c protein (Silurana tropicalis) 432 78.00% Myocyte‐specific enhancer factor 2A homolog (XMEF2A1) (xMEF2A) (Serum response factor‐ ARP38696_P050 MEF2A_XENLA like protein 2) (SL‐2) Xenopus laevis (African clawed frog) 516 78.00% ARP38696_P050 Q2KHS4_XENLA MGC131033 protein Xenopus laevis (African clawed frog) 497 78.00% Xenopus tropicalis (Western clawed frog) ARP38696_P050 Q0IHY6_XENTR Myocyte enhancer factor 2D (Silurana tropicalis) 496 78.00% ARP38696_P050 B7ZQS1_XENLA SRF‐related protein (Clone SL‐1) Xenopus laevis (African clawed frog) 498 78.00%

Myocyte‐specific enhancer factor 2D homolog ARP38696_P050 MEF2D_XENLA (Serum response factor‐like protein 1) (SL‐1) Xenopus laevis (African clawed frog) 498 78.00% MEF2D ARP38633_P050 Q6GNN3_XENLA MGC80986 protein Xenopus laevis (African clawed frog) 429 100.00% MEF2D ARP38633_P050 C0J6M9_XENLA MEF2A alpha 1b isoform Xenopus laevis (African clawed frog) 406 100.00% MEF2D ARP38633_P050 C0J6M8_XENLA MEF2A alpha 1c isoform Xenopus laevis (African clawed frog) 142 100.00% MEF2D ARP38633_P050 C0J6M7_XENLA MEF2A MADS box isoform Xenopus laevis (African clawed frog) 67 100.00% MEF2D ARP38633_P050 C0J6M6_XENLA MEF2A alpha 2 isoform Xenopus laevis (African clawed frog) 477 100.00% MEF2D ARP38633_P050 C0J6M5_XENLA MEF2A alpha 12b isoform Xenopus laevis (African clawed frog) 448 100.00% Xenopus tropicalis (Western clawed frog) MEF2D ARP38633_P050 B4F6K5_XENTR Putative uncharacterized protein (Silurana tropicalis) 219 100.00% Xenopus tropicalis (Western clawed frog) MEF2D ARP38633_P050 A9JTN7_XENTR Mef2c protein (Silurana tropicalis) 432 100.00% Myocyte‐specific enhancer factor 2A homolog (XMEF2A1) (xMEF2A) (Serum response factor‐ MEF2D ARP38633_P050 MEF2A_XENLA like protein 2) (SL‐2) Xenopus laevis (African clawed frog) 516 100.00% MEF2D ARP38633_P050 Q9PSD8_XENLA DNA binding protein MEF2 Xenopus laevis (African clawed frog) 382 78.00% MEF2D ARP38633_P050 Q2KHS4_XENLA MGC131033 protein Xenopus laevis (African clawed frog) 497 85.00% Xenopus tropicalis (Western clawed frog) MEF2D ARP38633_P050 Q0IHY6_XENTR Myocyte enhancer factor 2D (Silurana tropicalis) 496 85.00% MEF2D ARP38633_P050 B7ZQS1_XENLA SRF‐related protein (Clone SL‐1) Xenopus laevis (African clawed frog) 498 85.00%

Myocyte‐specific enhancer factor 2D homolog MEF2D ARP38633_P050 MEF2D_XENLA (Serum response factor‐like protein 1) (SL‐1) Xenopus laevis (African clawed frog) 498 85.00% Alkbh3 ARP55429_P050 Q5PPV1_XENLA LOC496071 protein Xenopus laevis (African clawed frog) 278 92.00% Xenopus tropicalis (Western clawed frog) papolg ARP40991_P050 Q6DJR7_XENTR Poly(A) polymerase beta (Testis specific) (Silurana tropicalis) 752 85.00% papolg ARP40991_P050 Q3I527_XENLA SRP 3'‐adenylating protein Xenopus laevis (African clawed frog) 751 85.00% papolg ARP40991_P050 B7ZQI5_XENLA LOC733387 protein Xenopus laevis (African clawed frog) 750 85.00% papss2a ARP48642_P050 Q6PA85_XENLA MGC68677 protein Xenopus laevis (African clawed frog) 621 92.00% 3'‐phosphoadenosine 5'‐phosphosulfate Xenopus tropicalis (Western clawed frog) papss2a ARP48642_P050 Q6DIN0_XENTR synthase 1 (Silurana tropicalis) 624 85.00% papss2a ARP48642_P050 Q498H6_XENLA MGC114937 protein Xenopus laevis (African clawed frog) 624 85.00% Xenopus tropicalis (Western clawed frog) Sfrs1 ARP40490_P050 Q6GLG3_XENTR Splicing factor, arginine/serine‐rich 9 (Silurana tropicalis) 225 100.00% Sfrs1 ARP40490_P050 Q5XGY8_XENLA LOC495254 protein Xenopus laevis (African clawed frog) 230 100.00% Sfrs1 ARP40490_P050 Q8AVB5_XENLA Sfrs1 protein (Fragment) Xenopus laevis (African clawed frog) 283 92.00% Sfrs1 ARP40490_P050 Q0IHK2_XENLA Sfrs1 protein (Fragment) Xenopus laevis (African clawed frog) 296 92.00% Sfrs1 ARP40490_P050 A1A628_XENLA Sfrs1 protein (Fragment) Xenopus laevis (African clawed frog) 294 92.00% Serine/arginine‐rich splicing factor 1 (Splicing Xenopus tropicalis (Western clawed frog) Sfrs1 ARP40490_P050 SRSF1_XENTR factor, arginine/serine‐rich 1) (Silurana tropicalis) 267 92.00% ARP40692_T100 Q8AVB5_XENLA Sfrs1 protein (Fragment) Xenopus laevis (African clawed frog) 283 100.00% ARP40692_T100 Q0IHK2_XENLA Sfrs1 protein (Fragment) Xenopus laevis (African clawed frog) 296 100.00% ARP40692_T100 A1A628_XENLA Sfrs1 protein (Fragment) Xenopus laevis (African clawed frog) 294 100.00% Serine/arginine‐rich splicing factor 1 (Splicing Xenopus tropicalis (Western clawed frog) ARP40692_T100 SRSF1_XENTR factor, arginine/serine‐rich 1) (Silurana tropicalis) 267 100.00% Xenopus tropicalis (Western clawed frog) ARP40692_T100 Q6GLG3_XENTR Splicing factor, arginine/serine‐rich 9 (Silurana tropicalis) 225 92.00% ARP40692_T100 Q5XGY8_XENLA LOC495254 protein Xenopus laevis (African clawed frog) 230 92.00% trub2 ARP48348_T100 A1L2U6_XENLA LOC100036957 protein Xenopus laevis (African clawed frog) 329 81.00% Probable tRNA pseudouridine synthase 2 (EC Xenopus tropicalis (Western clawed frog) trub2 ARP48348_T100 TRUB2_XENTR 5.4.99.‐) (Silurana tropicalis) 325 81.00% bup ARP42467_T100 Q68F26_XENLA MGC82230 protein Xenopus laevis (African clawed frog) 383 100.00% Xenopus tropicalis (Western clawed frog) bup ARP42467_T100 B1H183_XENTR LOC100145317 protein (Silurana tropicalis) 383 100.00% Xenopus tropicalis (Western clawed frog) ARP55144_P050 K0284_XENTR Protein KIAA0284 homolog (Silurana tropicalis) 1628 76.00% ARP55144_P050 K0284_XENLA Protein KIAA0284 homolog Xenopus laevis (African clawed frog) 1610 76.00% ARP34202_P050 A9JS62_XENLA LOC100127317 protein (Fragment) Xenopus laevis (African clawed frog) 580 76.00% ARP39102_P050 Q98SI7_XENLA Transcription factor Otx1 Xenopus laevis (African clawed frog) 339 100.00% Xenopus tropicalis (Western clawed frog) ARP39102_P050 Q6P4Y7_XENTR Orthodenticle homeobox 1 (Silurana tropicalis) 336 100.00% ARP39102_P050 Q0IH93_XENLA Otx1‐A protein Xenopus laevis (African clawed frog) 338 100.00% Xenopus tropicalis (Western clawed frog) ARP39102_P050 B1H3B9_XENTR Cone‐rod homeobox (Silurana tropicalis) 290 92.00% Homeobox protein otx5 (Orthodenticle Xenopus tropicalis (Western clawed frog) ARP39102_P050 OTX5_XENTR homolog 5) (Silurana tropicalis) 290 92.00% Homeobox protein otx5‐B (Orthodenticle ARP39102_P050 OTX5B_XENLA homolog 5‐B) (XOtx5b) Xenopus laevis (African clawed frog) 290 92.00% Homeobox protein otx5‐A (Orthodenticle ARP39102_P050 OTX5A_XENLA homolog 5‐A) (Xotx5) Xenopus laevis (African clawed frog) 290 92.00% Xenopus tropicalis (Western clawed frog) ARP39102_P050 OTX2_XENTR Homeobox protein OTX2 (Orthodenticle 2) (Silurana tropicalis) 289 92.00% Homeobox protein OTX2‐B (xOTX2‐B) (Orthodenticle 2‐B) (Orthodenticle‐A‐like ARP39102_P050 OTX2B_XENLA protein B) Xenopus laevis (African clawed frog) 289 92.00% Homeobox protein OTX2‐A (xOTX2‐A) (Orthodenticle 2‐A) (Orthodenticle‐A‐like ARP39102_P050 OTX2A_XENLA protein A) Xenopus laevis (African clawed frog) 288 92.00% ARP39102_P050 Q6UEE0_XENLA Homeodomain protein (Phox2a protein) Xenopus laevis (African clawed frog) 281 85.00% ARP39102_P050 Q6UED8_XENLA Homeodomain protein Xenopus laevis (African clawed frog) 293 78.00% ARP39102_P050 Q5XGX2_XENLA LOC495120 protein Xenopus laevis (African clawed frog) 293 78.00% Xenopus tropicalis (Western clawed frog) ARP39102_P050 B1WBH8_XENTR Phox2b protein (Silurana tropicalis) 293 78.00% ARP41158_T100 Q4QQX7_XENLA Thex1 protein Xenopus laevis (African clawed frog) 348 92.00% Xenopus tropicalis (Western clawed frog) ARP41158_T100 A9JSA4_XENTR Putative uncharacterized protein LOC548900 (Silurana tropicalis) 345 92.00% Xenopus tropicalis (Western clawed frog) ARP41158_T100 Q28FF6_XENTR Exonuclease 1 (Silurana tropicalis) 345 92.00% narg1l ARP48989_P050 Q9I8M2_XENLA Putative N‐terminal acetyltransferase Xenopus laevis (African clawed frog) 846 100.00% Xenopus tropicalis (Western clawed frog) narg1l ARP48989_P050 B3DLA3_XENTR Putative uncharacterized protein (Silurana tropicalis) 864 100.00% NMDA receptor regulated 1‐like (Narg1l narg1l ARP48989_P050 A8WH35_XENLA protein) Xenopus laevis (African clawed frog) 864 100.00% narg1l ARP48989_P050 A0JMW5_XENLA Narg1l protein (Fragment) Xenopus laevis (African clawed frog) 619 100.00% Fes ARP54608_P050 Q6GNQ8_XENLA MGC80946 protein Xenopus laevis (African clawed frog) 822 85.00% ARP40753_T100 Q6P9H8_XENLA MGC69160 protein Xenopus laevis (African clawed frog) 346 100.00% Ppp1r8 protein (Protein phosphatase 1, Xenopus tropicalis (Western clawed frog) ARP40753_T100 Q28G86_XENTR regulatory (Inhibitor) subunit 8) (Silurana tropicalis) 346 100.00% ARP40753_T100 Q05AU6_XENLA Ppp1r8_predicted protein Xenopus laevis (African clawed frog) 346 100.00% ARP56234_P050 Q6NRI2_XENLA MGC83797 protein Xenopus laevis (African clawed frog) 538 92.00% Xenopus tropicalis (Western clawed frog) ARP56234_P050 Q6DJ21_XENTR Kelch‐like 7 (Silurana tropicalis) 538 92.00% P100604_T100 Q6DJL5_XENLA C‐ets‐1b protein Xenopus laevis (African clawed frog) 439 78.00% Xenopus tropicalis (Western clawed frog) P100604_T100 B3DM35_XENTR LOC100170599 protein (Silurana tropicalis) 438 78.00% P100604_T100 A1L2V8_XENLA Ets1a‐a protein Xenopus laevis (African clawed frog) 438 76.00% P100604_T100 ETS1A_XENLA Protein c‐ets‐1‐A (C‐ets‐1A) Xenopus laevis (African clawed frog) 438 76.00% Xenopus tropicalis (Western clawed frog) TPAP ARP40936_P050 Q07G32_XENTR Poly(A) polymerase alpha (Pap) (Fragment) (Silurana tropicalis) 474 92.00% Xenopus tropicalis (Western clawed frog) TPAP ARP40936_P050 B5DEV0_XENTR Putative uncharacterized protein (Silurana tropicalis) 732 92.00% TPAP ARP40936_P050 Q6P703_XENLA Pap protein Xenopus laevis (African clawed frog) 731 84.00% Poly(A) polymerase type 3 (PAP) (EC 2.7.7.19) (Polynucleotide adenylyltransferase) TPAP ARP40936_P050 PAPO3_XENLA (Fragment) Xenopus laevis (African clawed frog) 400 84.00% Poly(A) polymerase alpha‐A (PAP‐alpha‐A) (EC 2.7.7.19) (Polynucleotide adenylyltransferase TPAP ARP40936_P050 PAPO1_XENLA alpha‐A) (Fragment) Xenopus laevis (African clawed frog) 715 84.00% Xenopus tropicalis (Western clawed frog) senp5 ARP55489_P050 B0JZZ7_XENTR Senp5 protein (Fragment) (Silurana tropicalis) 307 91.00% Xenopus tropicalis (Western clawed frog) KPNA1 ARP54670_P050 Q6P4X0_XENTR Putative uncharacterized protein MGC76184 (Silurana tropicalis) 538 92.00% KPNA1 ARP54670_P050 Q70PC5_XENLA Importin alpha 5.1 protein Xenopus laevis (African clawed frog) 537 78.00% KPNA1 ARP54670_P050 Q70PC4_XENLA Importin alpha 5.2 protein Xenopus laevis (African clawed frog) 537 78.00% KPNA1 ARP54670_P050 Q6IP69_XENLA Putative uncharacterized protein Xenopus laevis (African clawed frog) 537 78.00% CUGBP Elav‐like family member 2 (CELF‐2) (Bruno‐like protein 3) (CUG triplet repeat RNA‐ binding protein 2) (CUG‐BP2) (CUG‐BP‐ and ETR‐3‐like factor 2) (ELAV‐type RNA‐binding protein 3) (ETR‐3) (RNA‐binding protein Xenopus tropicalis (Western clawed frog) ARP40667_P050 CELF2_XENTR BRUNOL‐3) (Silurana tropicalis) 513 85.00% Xenopus tropicalis (Western clawed frog) AIFM2 AVARP09054_P050 AIFM2_XENTR Apoptosis‐inducing factor 2 (EC 1.‐.‐.‐) (Silurana tropicalis) 374 83.00% AIFM2 AVARP09054_P050 AIFM2_XENLA Apoptosis‐inducing factor 2 (EC 1.‐.‐.‐) Xenopus laevis (African clawed frog) 374 83.00% Xenopus tropicalis (Western clawed frog) LOC100036704 ARP42895_P050 A1L0Y3_XENTR LOC100036704 protein (Fragment) (Silurana tropicalis) 1675 76.00% MrHox4 ARP39582_P050 Q6TGB6_XENLA HOXD4 (Fragment) Xenopus laevis (African clawed frog) 218 100.00% Xenopus tropicalis (Western clawed frog) MrHox4 ARP39582_P050 Q5EB31_XENTR Hoxb4 protein (Fragment) (Silurana tropicalis) 233 100.00% MrHox4 ARP39582_P050 Q2TAR0_XENLA Putative uncharacterized protein Xenopus laevis (African clawed frog) 237 100.00% MrHox4 ARP39582_P050 B8XR32_XENLA Homeobox protein Hoxb‐4 (Fragment) Xenopus laevis (African clawed frog) 230 100.00% Xenopus tropicalis (Western clawed frog) MrHox4 ARP39582_P050 B1WAY9_XENTR Hoxb4 protein (Silurana tropicalis) 234 100.00% MrHox4 ARP39582_P050 HXB4_XENLA Homeobox protein Hox‐B4 (Xhox‐1A) Xenopus laevis (African clawed frog) 232 100.00% Xenopus tropicalis (Western clawed frog) MrHox4 ARP39582_P050 Q5M797_XENTR Homeobox A5 (Silurana tropicalis) 274 90.00% IRF‐1 ARP38128_P050 Q6GPX1_XENLA MGC82544 protein Xenopus laevis (African clawed frog) 302 92.00% IRF‐1 ARP38128_P050 Q6PB00_XENLA MGC68691 protein Xenopus laevis (African clawed frog) 298 92.00% Xenopus tropicalis (Western clawed frog) IRF‐1 ARP38128_P050 Q6DIY7_XENTR Interferon regulatory factor 1 (Silurana tropicalis) 302 92.00% IRF‐1 ARP38128_P050 Q6DED7_XENLA Irf2‐prov protein Xenopus laevis (African clawed frog) 344 90.00% Interferon regulatory factor 2 (Novel protein similar to interferon regulatory factor Xenopus tropicalis (Western clawed frog) IRF‐1 ARP38128_P050 Q66JJ2_XENTR transcription factor) (Silurana tropicalis) 347 90.00% IRF‐1 ARP38128_P050 Q5PQ39_XENLA LOC495990 protein Xenopus laevis (African clawed frog) 347 90.00% Xenopus tropicalis (Western clawed frog) P100907_T100 PO3F4_XENTR POU domain, class 3, transcription factor 4 (Silurana tropicalis) 360 85.00% POU domain, class 3, transcription factor 4‐A (Transcription factor POU2) (XlPOU 2) pou3f4 P100907_T100 P3F4A_XENLA (XlPOU2) Xenopus laevis (African clawed frog) 361 85.00% pou3f4 P100907_T100 P3F4B_XENLA POU domain, class 3, transcription factor 4‐B Xenopus laevis (African clawed frog) 356 78.00% DCK1 protein (Deoxycytidine kinase 1) (EC TK2 ARP51775_P050 Q5QKN1_XENLA 2.7.1.74) Xenopus laevis (African clawed frog) 265 85.00% TK2 ARP51775_P050 Q5XHI7_XENLA LOC494987 protein Xenopus laevis (African clawed frog) 263 85.00% Xenopus tropicalis (Western clawed frog) TK2 ARP51775_P050 Q5BL83_XENTR Dck protein (Silurana tropicalis) 265 85.00% Xenopus tropicalis (Western clawed frog) TK2 ARP51775_P050 Q28D85_XENTR Novel protein similar to deoxycytidine kinase (Silurana tropicalis) 264 84.00% Dck‐prov protein (Deoxycytidine kinase 2) (EC TK2 ARP51775_P050 Q6DD33_XENLA 2.7.1.74) Xenopus laevis (African clawed frog) 264 84.00% ORF Names:Bm1_02805 EMBL EDP39124.1OrganismBrugia malayi Xenopus tropicalis (Western clawed frog) (Filarial nematode worm) ARP58450_P050 Q07G86_XENTR 2 (P50) (Fragment) (Silurana tropicalis) 186 100.00% ORF Names:Bm1_02805 EMBL EDP39124.1OrganismBrugia malayi Xenopus tropicalis (Western clawed frog) (Filarial nematode worm) ARP58450_P050 DCTN2_XENTR Dynactin subunit 2 (Silurana tropicalis) 405 100.00% ORF Names:Bm1_02805 EMBL EDP39124.1OrganismBrugia malayi (Filarial nematode worm) ARP58450_P050 DCT2A_XENLA Dynactin subunit 2‐A Xenopus laevis (African clawed frog) 403 100.00% ORF Names:Bm1_02805 EMBL EDP39124.1OrganismBrugia malayi (Filarial nematode worm) ARP58450_P050 DCT2B_XENLA Dynactin subunit 2‐B Xenopus laevis (African clawed frog) 403 92.00% Wingless‐type MMTV integration site family, Wnt5b ARP41279_P050 B7ZQY1_XENLA member 5A Xenopus laevis (African clawed frog) 380 100.00% Wnt5b ARP41279_P050 WNT5A_XENLA Protein Wnt‐5a (XWnt‐5a) Xenopus laevis (African clawed frog) 380 100.00% Wingless‐type MMTV integration site family, Xenopus tropicalis (Western clawed frog) Wnt5b ARP41279_P050 Q6DII0_XENTR member 5B (Silurana tropicalis) 360 83.00%

Wnt5b ARP41279_P050 WNT5B_XENLA Protein Wnt‐5b (Protein Wnt‐5c) (XWnt‐5C) Xenopus laevis (African clawed frog) 360 83.00% Xenopus tropicalis (Western clawed frog) FEZF1 ARP39321_T100 FEZF2_XENTR Fez family zinc finger protein 2 (Silurana tropicalis) 435 100.00% FEZF1 ARP39321_T100 FEZF2_XENLA Fez family zinc finger protein 2 Xenopus laevis (African clawed frog) 434 100.00% Xenopus tropicalis (Western clawed frog) FEZF1 ARP39321_T100 FEZF1_XENTR Fez family zinc finger protein 1 (Silurana tropicalis) 462 100.00% FEZF1 ARP39321_T100 FEZF1_XENLA Fez family zinc finger protein 1 Xenopus laevis (African clawed frog) 466 100.00% ORF Names:OsJ_30690 EMBL EAZ15275.1OrganismOryza sativa subsp. japonica (Rice) ARP58060_P050 Q7ZTP3_XENLA Xrpn10c protein (Fragment) Xenopus laevis (African clawed frog) 387 100.00% ORF Names:OsJ_30690 EMBL EAZ15275.1OrganismOryza sativa Proteasome (Prosome, macropain) 26S Xenopus tropicalis (Western clawed frog) subsp. japonica (Rice) ARP58060_P050 Q6NVQ2_XENTR subunit, non‐ATPase, 4 (Silurana tropicalis) 377 100.00% ORF Names:OsJ_30690 EMBL EAZ15275.1OrganismOryza sativa subsp. japonica (Rice) ARP58060_P050 Q588Y8_XENLA 26S proteasome subunit Xenopus laevis (African clawed frog) 355 100.00% ORF Names:OsJ_30690 EMBL EAZ15275.1OrganismOryza sativa 26S proteasome subunit (Proteasome subunit subsp. japonica (Rice) ARP58060_P050 Q588Y7_XENLA xrpn10) Xenopus laevis (African clawed frog) 376 100.00% ORF Names:OsJ_30690 EMBL EAZ15275.1OrganismOryza sativa subsp. japonica (Rice) ARP58060_P050 Q4V845_XENLA Xrpn10c protein Xenopus laevis (African clawed frog) 376 100.00% ORF Names:OsJ_30690 EMBL EAZ15275.1OrganismOryza sativa Xenopus tropicalis (Western clawed frog) subsp. japonica (Rice) ARP58060_P050 A9UM91_XENTR LOC100135276 protein (Fragment) (Silurana tropicalis) 133 100.00% ORF Names:CC1G_05695 EMBL EAU90157.2OrganismCoprinopsis cinerea (strain Okayama‐7 / 130 / FGSC 9003) (Inky cap fungus) Lanosterol synthase (2,3‐oxidosqualene‐ Xenopus tropicalis (Western clawed frog) (Hormographiella aspergillata) ARP41840_P050 Q28C87_XENTR lanosterol cyclase) (Fragment) (Silurana tropicalis) 241 85.00% ORF Names:CC1G_05695 EMBL EAU90157.2OrganismCoprinopsis cinerea (strain Okayama‐7 / 130 / FGSC 9003) (Inky cap fungus) Lanosterol synthase (2,3‐oxidosqualene‐ Xenopus tropicalis (Western clawed frog) (Hormographiella aspergillata) ARP41840_P050 Q0IHW7_XENTR lanosterol cyclase) (Silurana tropicalis) 730 85.00% ORF Names:VITISV_028347 EMBL CAN61196.1OrganismVitis vinifera (Grape) ARP44797_T100 Q6GM63_XENLA MGC83398 protein Xenopus laevis (African clawed frog) 308 100.00% ORF Names:VITISV_028347 EMBL CAN61196.1OrganismVitis vinifera RCE1 homolog, prenyl protein peptidase (S. Xenopus tropicalis (Western clawed frog) (Grape) ARP44797_T100 B7ZT68_XENTR cerevisiae) (Silurana tropicalis) 308 100.00% mtus1 ARP44419_P050 MTUS1_XENLA Isoform 2 Xenopus laevis (African clawed frog) 1197 78.00%

Microtubule‐associated tumor suppressor 1 homolog (F‐box protein 27) (Inner centromere KinI stimulator) (Mitochondrial tumor mtus1 ARP44419_P050 MTUS1_XENLA suppressor 1 homolog) Xenopus laevis (African clawed frog) 1338 78.00% Prdm12 ARP33218_P050 Q7T0V8_XENLA MGC68944 protein Xenopus laevis (African clawed frog) 355 91.00% Xenopus tropicalis (Western clawed frog) Prdm12 ARP33218_P050 Q0VFE6_XENTR PR domain containing 12 (Silurana tropicalis) 354 91.00% RIOK3 ARP42152_P050 Q6PAA2_XENLA MGC68555 protein Xenopus laevis (African clawed frog) 510 91.00% Xenopus tropicalis (Western clawed frog) RIOK3 ARP42152_P050 Q6DIF7_XENTR MGC89575 protein (RIO kinase 3 (Yeast)) (Silurana tropicalis) 508 91.00% RIOK3 ARP42152_P050 Q6DCR3_XENLA Riok3‐prov protein Xenopus laevis (African clawed frog) 508 91.00% ORF Names:zgc:171753 EMBL AAI51965.1 ZFIN ZDB‐GENE‐070928‐ 29OrganismDanio rerio (Zebrafish) Xenopus tropicalis (Western clawed frog) (Brachydanio rerio) ARP43055_T100 THOC4_XENTR THO complex subunit 4 (Tho4) (Silurana tropicalis) 260 100.00% ORF Names:zgc:171753 EMBL AAI51965.1 ZFIN ZDB‐GENE‐070928‐ 29OrganismDanio rerio (Zebrafish) (Brachydanio rerio) ARP43055_T100 THO4B_XENLA THO complex subunit 4‐B (Tho4‐B) Xenopus laevis (African clawed frog) 256 92.00% ORF Names:zgc:171753 EMBL AAI51965.1 ZFIN ZDB‐GENE‐070928‐ 29OrganismDanio rerio (Zebrafish) (Brachydanio rerio) ARP43055_T100 THO4A_XENLA THO complex subunit 4‐A (Tho4‐A) Xenopus laevis (African clawed frog) 256 92.00% ORF Names:GSPATT00014010001 EMBL CAK79043.1OrganismParamecium Xenopus tropicalis (Western clawed frog) tetraurelia ARP48821_P050 B2GUR3_XENTR LOC100158643 protein (Silurana tropicalis) 1134 100.00% Signal transducer and activator of AVARP09057_P050 STA32_XENLA transcription 3.2 (Protein Stat3‐A) Xenopus laevis (African clawed frog) 766 75.00% Signal transducer and activator of AVARP09057_P050 STA31_XENLA transcription 3.1 (Protein Stat3) (Xstat3) Xenopus laevis (African clawed frog) 769 80.00% ORF Names:CG14470 FlyBase FBgn0033046, Dmel_CG14470 EMBL AAF57301.2OrganismDrosophila melanogaster (Fruit fly) ARP47470_P050 Q0IHE4_XENLA Serpine1 protein Xenopus laevis (African clawed frog) 403 92.00% ORF Names:CG14470 FlyBase FBgn0033046, Dmel_CG14470 EMBL AAF57301.2OrganismDrosophila Xenopus tropicalis (Western clawed frog) melanogaster (Fruit fly) ARP47470_P050 B5DFQ5_XENTR LOC100127732 protein (Fragment) (Silurana tropicalis) 428 92.00% ORF Names:CG14470 FlyBase FBgn0033046, Dmel_CG14470 EMBL AAF57301.2OrganismDrosophila Xenopus tropicalis (Western clawed frog) melanogaster (Fruit fly) ARP47470_P050 A8WGZ7_XENTR LOC100127732 protein (Fragment) (Silurana tropicalis) 425 92.00% ORF Names:CG14470 FlyBase FBgn0033046, Dmel_CG14470 EMBL AAF57301.2OrganismDrosophila melanogaster (Fruit fly) ARP47470_P050 A5D8P7_XENLA LOC100049768 protein (Fragment) Xenopus laevis (African clawed frog) 420 92.00% ORF Names:CG14470 FlyBase FBgn0033046, Dmel_CG14470 EMBL AAF57301.2OrganismDrosophila melanogaster (Fruit fly) ARP47470_P050 Q6DD81_XENLA Serpine2‐prov protein Xenopus laevis (African clawed frog) 395 84.00% ORF Names:CG14470 FlyBase FBgn0033046, Dmel_CG14470 EMBL Serine (Or cysteine) proteinase inhibitor, clade AAF57301.2OrganismDrosophila E (Nexin, plasminogen activator inhibitor type Xenopus tropicalis (Western clawed frog) melanogaster (Fruit fly) ARP47470_P050 Q28C25_XENTR 1), member 2 (Silurana tropicalis) 395 84.00% ORF Names:CG14470 FlyBase FBgn0033046, Dmel_CG14470 EMBL AAF57301.2OrganismDrosophila melanogaster (Fruit fly) ARP47470_P050 Q0P032_XENLA Protease nexin‐1 Xenopus laevis (African clawed frog) 395 84.00%

ORF Names:TRIADDRAFT_56172 EMBL EDV24403.1OrganismTrichoplax adhaerens (Trichoplax reptans) ARP47199_T100 Q5M7D2_XENLA LOC496236 protein Xenopus laevis (African clawed frog) 345 100.00% ARP36498_P050 Q5XH08_XENLA LOC495097 protein (Fragment) Xenopus laevis (African clawed frog) 717 92.00% ARP36498_P050 Q52KY4_XENLA LOC495097 protein (Fragment) Xenopus laevis (African clawed frog) 693 92.00% ARP36498_P050 Q2VPF9_XENLA LOC495097 protein Xenopus laevis (African clawed frog) 846 92.00% ARP40219_T100 Q66KW5_XENLA MGC85374 protein Xenopus laevis (African clawed frog) 135 92.00% Xenopus tropicalis (Western clawed frog) ARP40219_T100 Q5I0T5_XENTR Hypothetical LOC496894 (Silurana tropicalis) 135 92.00% MEF2A ARP38634_P050 C0J6M9_XENLA MEF2A alpha 1b isoform Xenopus laevis (African clawed frog) 406 78.00% MEF2A ARP38634_P050 C0J6M6_XENLA MEF2A alpha 2 isoform Xenopus laevis (African clawed frog) 477 78.00% MEF2A ARP38634_P050 C0J6M5_XENLA MEF2A alpha 12b isoform Xenopus laevis (African clawed frog) 448 78.00% Myocyte‐specific enhancer factor 2A homolog (XMEF2A1) (xMEF2A) (Serum response factor‐ MEF2A ARP38634_P050 MEF2A_XENLA like protein 2) (SL‐2) Xenopus laevis (African clawed frog) 516 78.00% ARP48315_P050 Q6DKA8_XENLA MGC84728 protein Xenopus laevis (African clawed frog) 301 100.00% ARP48315_P050 Q6DEB3_XENLA MGC79025 protein Xenopus laevis (African clawed frog) 301 100.00% Xenopus tropicalis (Western clawed frog) ARP48315_P050 PHB2_XENTR Prohibitin‐2 (Silurana tropicalis) 301 100.00% Sema6d ARP49583_P050 Q2V0J3_XENLA Semaphorin 6D4 Xenopus laevis (African clawed frog) 1085 85.00% Xenopus tropicalis (Western clawed frog) Sema6d ARP49583_P050 B0JZE6_XENTR Sema6d protein (Silurana tropicalis) 1084 85.00% CREM AVARP01026_P050 Q8AVY5_XENLA Creb1‐prov protein Xenopus laevis (African clawed frog) 324 100.00% Xenopus tropicalis (Western clawed frog) CREM AVARP01026_P050 Q6NVP9_XENTR cAMP responsive element binding protein 1 (Silurana tropicalis) 327 100.00%

ORF Names:v1g243223OrganismNematostel la vectensis (Starlet sea anemone) ARP45057_P050 Q6DCR9_XENLA Aoc2‐prov protein Xenopus laevis (African clawed frog) 759 75.00%

ORF Names:v1g243223OrganismNematostel Xenopus tropicalis (Western clawed frog) la vectensis (Starlet sea anemone) ARP45057_P050 Q5BKL7_XENTR Aoc2 protein (Silurana tropicalis) 759 75.00%

ORF Names:v1g243223OrganismNematostel la vectensis (Starlet sea anemone) ARP45057_P050 A5PKN0_XENLA Putative uncharacterized protein Xenopus laevis (African clawed frog) 759 75.00% Pre‐mRNA‐splicing factor RBM22 (RNA‐ Xenopus tropicalis (Western clawed frog) rbm22 ARP40888_P050 RBM22_XENTR binding motif protein 22) (Silurana tropicalis) 417 92.00% Pre‐mRNA‐splicing factor RBM22 (RNA‐ rbm22 ARP40888_P050 RBM22_XENLA binding motif protein 22) Xenopus laevis (African clawed frog) 417 85.00%

Adenylosuccinate synthetase isozyme 1 (AMPSase 1) (AdSS 1) (EC 6.3.4.4) (Adenylosuccinate synthetase, basic isozyme) (Adenylosuccinate synthetase, muscle isozyme) (M‐type adenylosuccinate Xenopus tropicalis (Western clawed frog) ADSSL1 ARP48442_P050 PURA1_XENTR synthetase) (IMP‐‐aspartate ligase 1) (Silurana tropicalis) 452 100.00%

Adenylosuccinate synthetase isozyme 1 B (AMPSase 1 B) (AdSS 1 B) (EC 6.3.4.4) (Adenylosuccinate synthetase, basic isozyme B) (Adenylosuccinate synthetase, muscle isozyme B) (M‐type adenylosuccinate ADSSL1 ARP48442_P050 PUA1B_XENLA synthetase B) (IMP‐‐aspartate ligase 1 B) Xenopus laevis (African clawed frog) 454 100.00%

Adenylosuccinate synthetase isozyme 1 A (AMPSase 1 A) (AdSS 1 A) (EC 6.3.4.4) (Adenylosuccinate synthetase, basic isozyme A) (Adenylosuccinate synthetase, muscle isozyme A) (M‐type adenylosuccinate ADSSL1 ARP48442_P050 PUA1A_XENLA synthetase A) (IMP‐‐aspartate ligase 1 A) Xenopus laevis (African clawed frog) 454 100.00% Adenylosuccinate synthetase isozyme 2 (AMPSase 2) (AdSS 2) (EC 6.3.4.4) (Adenylosuccinate synthetase, acidic isozyme) (Adenylosuccinate synthetase, liver isozyme) (L‐type adenylosuccinate synthetase) (IMP‐‐ ADSSL1 ARP48442_P050 PURA2_XENLA aspartate ligase 2) Xenopus laevis (African clawed frog) 457 78.00%

Adenylosuccinate synthetase isozyme 2 B (AMPSase 2 B) (AdSS 2 B) (EC 6.3.4.4) (Adenylosuccinate synthetase, acidic isozyme B) (Adenylosuccinate synthetase, liver isozyme B) (L‐type adenylosuccinate synthetase B) Xenopus tropicalis (Western clawed frog) ADSSL1 ARP48442_P050 PUA2B_XENTR (IMP‐‐aspartate ligase 2 B) (Silurana tropicalis) 457 78.00% Adenylosuccinate synthetase isozyme 2 A (AMPSase 2 A) (AdSS 2 A) (EC 6.3.4.4) (Adenylosuccinate synthetase, acidic isozyme A) (Adenylosuccinate synthetase, liver isozyme A) (L‐type adenylosuccinate Xenopus tropicalis (Western clawed frog) ADSSL1 ARP48442_P050 PUA2A_XENTR synthetase A) (IMP‐‐aspartate ligase 2 A) (Silurana tropicalis) 457 78.00% KH domain‐containing, RNA‐binding, signal Xenopus tropicalis (Western clawed frog) ARP53110_P050 KHDR2_XENTR transduction‐associated protein 2 (Silurana tropicalis) 345 100.00% Xenopus tropicalis (Western clawed frog) ARP53110_P050 Q28FP2_XENTR Poly(RC) binding protein 2 (Silurana tropicalis) 335 83.00% BCL6 ARP40045_P050 Q6DCT1_XENLA Bcl6‐prov protein Xenopus laevis (African clawed frog) 701 85.00% BCL6 ARP40045_P050 Q5U4Y1_XENLA LOC495412 protein Xenopus laevis (African clawed frog) 701 85.00% Xenopus tropicalis (Western clawed frog) BCL6 ARP40045_P050 B1H333_XENTR Bcl6 protein (Silurana tropicalis) 702 85.00%

ORF Names:GSTENG00006895001 EMBL CAF91918.1OrganismTetraodon nigroviridis (Green puffer) ARP38470_T100 Q6GNT4_XENLA LOC443646 protein (Fragment) Xenopus laevis (African clawed frog) 247 100.00%

ORF Names:GSTENG00006895001 EMBL CAF91918.1OrganismTetraodon Histone‐lysine N‐methyltransferase EZH2 (EC Xenopus tropicalis (Western clawed frog) nigroviridis (Green puffer) ARP38470_T100 EZH2_XENTR 2.1.1.43) (Enhancer of zeste homolog 2) (Silurana tropicalis) 748 100.00%

ORF Names:GSTENG00006895001 EMBL CAF91918.1OrganismTetraodon Histone‐lysine N‐methyltransferase EZH2 (EC nigroviridis (Green puffer) ARP38470_T100 EZH2B_XENLA 2.1.1.43) (Enhancer of zeste homolog 2‐B) Xenopus laevis (African clawed frog) 748 100.00%

ORF Names:GSTENG00006895001 EMBL CAF91918.1OrganismTetraodon Histone‐lysine N‐methyltransferase EZH2 (EC nigroviridis (Green puffer) ARP38470_T100 EZH2A_XENLA 2.1.1.43) (Enhancer of zeste homolog 2‐A) Xenopus laevis (African clawed frog) 748 92.00% Probable tRNA (uracil‐O(2)‐)‐ 2310079F23Rik ARP53032_P050 TRM44_XENLA methyltransferase (EC 2.1.1.n2) Xenopus laevis (African clawed frog) 668 100.00% Wdtc1 ARP55145_P050 Q6PA37_XENLA MGC68614 protein Xenopus laevis (African clawed frog) 668 78.00% Wdtc1 ARP55145_P050 Q6NS11_XENLA MGC78868 protein Xenopus laevis (African clawed frog) 671 78.00% Mta2 ARP38509_T100 Q6AZP0_XENLA MGC83056 protein Xenopus laevis (African clawed frog) 672 80.00% Protein‐kinase, interferon‐inducible double stranded RNA dependent inhibitor, repressor Xenopus tropicalis (Western clawed frog) ARP56594_P050 Q6P892_XENTR of (P58 repressor) (Silurana tropicalis) 753 100.00% ARP42915_P050 Q6GR05_XENLA LOC443569 protein (Fragment) Xenopus laevis (African clawed frog) 444 92.00% ARP42915_P050 Q4KLW9_XENLA LOC443569 protein Xenopus laevis (African clawed frog) 675 92.00% Xenopus tropicalis (Western clawed frog) ARP42915_P050 B0JZ60_XENTR LOC100145156 protein (Fragment) (Silurana tropicalis) 444 85.00% Sphingolipid delta(4)‐desaturase DES1 (EC 1.14.‐.‐) (Degenerative spermatocyte homolog Xenopus tropicalis (Western clawed frog) DEGS1 ARP45501_P050 DEGS1_XENTR 1) (Silurana tropicalis) 323 92.00% DEGS1 ARP45501_P050 Q6AZN7_XENLA MGC83098 protein Xenopus laevis (African clawed frog) 322 85.00% DEGS1 ARP45501_P050 Q7SYZ6_XENLA Degs‐prov protein Xenopus laevis (African clawed frog) 322 78.00% Degenerative spermatocyte homolog 3, lipid Xenopus tropicalis (Western clawed frog) DEGS1 ARP45501_P050 Q6P8B6_XENTR desaturase (Silurana tropicalis) 322 78.00% Novel protein containing fatty acid desaturase Xenopus tropicalis (Western clawed frog) DEGS1 ARP45501_P050 Q28J37_XENTR domain (Silurana tropicalis) 322 78.00%

Heterogeneous nuclear ribonucleoprotein A3 ARP41196_T100 RO31_XENLA homolog 1 (hnRNP A3(A)) Xenopus laevis (African clawed frog) 373 81.00% Lanosterol synthase (2,3‐oxidosqualene‐ Xenopus tropicalis (Western clawed frog) LSS ARP41839_P050 Q0IHW7_XENTR lanosterol cyclase) (Silurana tropicalis) 730 92.00% Xenopus tropicalis (Western clawed frog) Fnbp1 ARP38438_P050 Q08D42_XENTR Formin‐binding protein 17 (Silurana tropicalis) 605 85.00% Xenopus tropicalis (Western clawed frog) Fnbp1 ARP38438_P050 A4IIP7_XENTR Putative uncharacterized protein (Silurana tropicalis) 649 85.00% Fnbp1 ARP38438_P050 FNBP1_XENLA Formin‐binding protein 1 homolog Xenopus laevis (African clawed frog) 610 78.00% Fnbp1 ARP38438_P050 Q2TAF6_XENLA MGC132162 protein Xenopus laevis (African clawed frog) 550 78.00% Formin‐binding protein 1‐like (Transducer of Cdc42‐dependent actin assembly protein 1) Xenopus tropicalis (Western clawed frog) Fnbp1 ARP38438_P050 FBP1L_XENTR (Toca‐1) (Silurana tropicalis) 550 78.00% Formin‐binding protein 1‐like (Transducer of Cdc42‐dependent actin assembly protein 1) Fnbp1 ARP38438_P050 FBP1L_XENLA (Toca‐1) Xenopus laevis (African clawed frog) 543 78.00%

mRNA cap guanine‐N7 methyltransferase (EC 2.1.1.56) (RG7MT1) (mRNA (guanine‐N(7)‐)‐ methyltransferase) (mRNA cap Xenopus tropicalis (Western clawed frog) RNMT ARP40493_P050 MCES_XENTR methyltransferase) (Silurana tropicalis) 405 76.00%

mRNA cap guanine‐N7 methyltransferase (EC 2.1.1.56) (RG7MT1) (mRNA (guanine‐N(7)‐)‐ methyltransferase) (mRNA cap RNMT ARP40493_P050 MCES_XENLA methyltransferase) (xCMT1) Xenopus laevis (African clawed frog) 402 76.00% ARP54735_P050 Q640H7_XENLA LOC494671 protein Xenopus laevis (African clawed frog) 281 85.00% Xenopus tropicalis (Western clawed frog) ARP54735_P050 Q5M8E5_XENTR Isopentenyl‐diphosphate delta isomerase 2 (Silurana tropicalis) 227 85.00% Sister chromatid cohesion protein PDS5 Pds5a ARP46222_P050 PD5AB_XENLA homolog A‐B Xenopus laevis (African clawed frog) 1323 78.00% Sister chromatid cohesion protein PDS5 Pds5a ARP46222_P050 PD5AA_XENLA homolog A‐A Xenopus laevis (African clawed frog) 1323 78.00% Xenopus tropicalis (Western clawed frog) pyrB ARP46104_P050 A4QN94_XENTR LOC100125119 protein (Fragment) (Silurana tropicalis) 2232 92.00% ORF Names:PANDA_005622 EMBL responsive protein (Oxidative EFB21143.1OrganismAiluropoda stress responsive 1) (Putative uncharacterized Xenopus tropicalis (Western clawed frog) melanoleuca (Giant panda) ARP56915_P050 Q6P7K4_XENTR protein MGC76290) (Silurana tropicalis) 291 100.00% ORF Names:PANDA_005622 EMBL EFB21143.1OrganismAiluropoda melanoleuca (Giant panda) ARP56915_P050 Q6GQD6_XENLA MGC80149 protein Xenopus laevis (African clawed frog) 286 100.00% ORF Names:PANDA_005622 EMBL EFB21143.1OrganismAiluropoda melanoleuca (Giant panda) ARP56915_P050 Q6GLJ4_XENLA LOC443717 protein (Fragment) Xenopus laevis (African clawed frog) 300 100.00% Xenopus tropicalis (Western clawed frog) gsh2 ARP39863_T100 Q1WKL2_XENTR Genomic‐screened homeobox 1 (Silurana tropicalis) 243 85.00% GS homeobox 2 (Genomic‐screened Xenopus tropicalis (Western clawed frog) gsh2 ARP39863_T100 Q28CW5_XENTR homeobox 2) (Silurana tropicalis) 248 91.00% ARIH1 ARP43054_T100 Q32NS4_XENLA MGC130861 protein Xenopus laevis (African clawed frog) 529 92.00% Xenopus tropicalis (Western clawed frog) ARIH1 ARP43054_T100 B1H1E4_XENTR Arih1 protein (Silurana tropicalis) 529 92.00% ORF Names:LbrM21_V2.0440 EMBL CAM38824.1OrganismLeishmania Xenopus tropicalis (Western clawed frog) braziliensis ARP39008_P050 CP080_XENTR UPF0468 protein C16orf80 homolog (Silurana tropicalis) 193 100.00% ORF Names:LbrM21_V2.0440 EMBL CAM38824.1OrganismLeishmania braziliensis ARP39008_P050 CP080_XENLA UPF0468 protein C16orf80 homolog Xenopus laevis (African clawed frog) 193 100.00%

ORF Names:CH211‐190H2.2‐001 EMBL CAQ15255.1OrganismDanio rerio Zona pellucida‐like domain‐containing protein (Zebrafish) (Brachydanio rerio) ARP53315_P050 ZPLD1_XENLA 1 (ZP domain‐containing protein 1) Xenopus laevis (African clawed frog) 415 91.00%

ORF Names:zgc:153115 ZFIN ZDB‐GENE‐ 061013‐418OrganismDanio rerio (Zebrafish) (Brachydanio rerio) ARP38365_P050 Q6GN26_XENLA MGC83597 protein Xenopus laevis (African clawed frog) 499 100.00%

ORF Names:zgc:153115 ZFIN ZDB‐GENE‐ 061013‐418OrganismDanio rerio Novel kruppel‐like factor family protein Xenopus tropicalis (Western clawed frog) (Zebrafish) (Brachydanio rerio) ARP38365_P050 Q28CC3_XENTR (Fragment) (Silurana tropicalis) 226 100.00%

ORF Names:zgc:153115 ZFIN ZDB‐GENE‐ 061013‐418OrganismDanio rerio Xenopus tropicalis (Western clawed frog) (Zebrafish) (Brachydanio rerio) ARP38365_P050 Q0VA55_XENTR Kruppel‐like factor 11 (Silurana tropicalis) 499 100.00% ORF Names:zgc:153115 ZFIN ZDB‐GENE‐ 061013‐418OrganismDanio rerio (Zebrafish) (Brachydanio rerio) ARP38365_P050 Q6NRF0_XENLA MGC83869 protein Xenopus laevis (African clawed frog) 495 92.00%

ORF Names:zgc:153115 ZFIN ZDB‐GENE‐ 061013‐418OrganismDanio rerio (Zebrafish) (Brachydanio rerio) ARP38365_P050 Q5RJX0_XENLA LOC495832 protein Xenopus laevis (African clawed frog) 450 92.00%

ORF Names:zgc:153115 ZFIN ZDB‐GENE‐ 061013‐418OrganismDanio rerio (Zebrafish) (Brachydanio rerio) ARP38365_P050 Q56A67_XENLA MGC98877 protein Xenopus laevis (African clawed frog) 452 92.00%

ORF Names:zgc:153115 ZFIN ZDB‐GENE‐ 061013‐418OrganismDanio rerio (Zebrafish) (Brachydanio rerio) ARP38365_P050 Q91633_XENLA BTEB Xenopus laevis (African clawed frog) 292 100.00%

ORF Names:zgc:153115 ZFIN ZDB‐GENE‐ 061013‐418OrganismDanio rerio BTEB (Basic transcription element binding (Zebrafish) (Brachydanio rerio) ARP38365_P050 Q91632_XENLA protein 1) Xenopus laevis (African clawed frog) 292 100.00%

ORF Names:zgc:153115 ZFIN ZDB‐GENE‐ 061013‐418OrganismDanio rerio Xenopus tropicalis (Western clawed frog) (Zebrafish) (Brachydanio rerio) ARP38365_P050 A9ULE3_XENTR Klf9 protein (Kruppel‐like factor 9) (Silurana tropicalis) 289 100.00%

ORF Names:zgc:153115 ZFIN ZDB‐GENE‐ 061013‐418OrganismDanio rerio Xenopus tropicalis (Western clawed frog) (Zebrafish) (Brachydanio rerio) ARP38365_P050 A4IIB6_XENTR Klf13 protein (Silurana tropicalis) 258 100.00% ARP38700_T100 Q7ZXL2_XENLA Meox2‐prov protein Xenopus laevis (African clawed frog) 298 85.00% Xenopus tropicalis (Western clawed frog) ARP38700_T100 B1H161_XENTR Meox2 protein (Silurana tropicalis) 300 85.00% ARP38700_T100 MEOX2_XENLA Homeobox protein MOX‐2 Xenopus laevis (African clawed frog) 298 85.00% Xenopus tropicalis (Western clawed frog) CH211‐145O7.7 ARP41342_P050 Q5BKG6_XENTR MGC108414 protein (Silurana tropicalis) 439 76.00% ARP38031_T100 Q8AVT0_XENLA MGC53543 protein Xenopus laevis (African clawed frog) 434 100.00% ARP38031_T100 Q7SZ25_XENLA Eno1‐prov protein Xenopus laevis (African clawed frog) 434 100.00% Xenopus tropicalis (Western clawed frog) ARP38031_T100 Q6P8E1_XENTR Enolase 1, (Alpha) (Silurana tropicalis) 434 100.00% Xenopus tropicalis (Western clawed frog) ARP38031_T100 B0BMH7_XENTR Eno1 protein (Silurana tropicalis) 434 100.00% Alpha‐enolase (EC 4.2.1.11) (2‐phospho‐D‐ glycerate hydro‐lyase) (2‐phosphoglycerate ARP38031_T100 ENOA_XENLA dehydratase) Xenopus laevis (African clawed frog) 434 100.00% ARP38031_T100 Q7ZXA3_XENLA Eno3‐prov protein Xenopus laevis (African clawed frog) 434 92.00% Mgc108129 protein (Putative uncharacterized Xenopus tropicalis (Western clawed frog) ARP38031_T100 Q4VA70_XENTR protein mgc108129) (Silurana tropicalis) 434 92.00% Xenopus tropicalis (Western clawed frog) hal ARP45692_P050 Q6DF42_XENTR Histidine ammonia‐lyase (Silurana tropicalis) 561 92.00% hal ARP45692_P050 Q6AZU6_XENLA Hal‐prov protein Xenopus laevis (African clawed frog) 658 92.00% hal ARP45692_P050 Q0VGW8_XENLA LOC100125662 protein Xenopus laevis (African clawed frog) 664 92.00% Xenopus tropicalis (Western clawed frog) hal ARP45692_P050 B3DM33_XENTR Putative uncharacterized protein (Silurana tropicalis) 568 92.00% Xenopus tropicalis (Western clawed frog) hal ARP45692_P050 B1WAW6_XENTR LOC100145719 protein (Silurana tropicalis) 657 92.00% hal ARP45692_P050 Q6GMC2_XENLA MGC81887 protein Xenopus laevis (African clawed frog) 664 85.00% Xenopus tropicalis (Western clawed frog) LOC100036940 ARP36575_P050 Q6DJ57_XENTR Annexin A11 (Silurana tropicalis) 498 78.00% LOC100036940 ARP36575_P050 Q641H0_XENLA MGC81584 protein Xenopus laevis (African clawed frog) 502 78.00% LOC100036940 ARP36575_P050 A1L2S9_XENLA LOC100036940 protein Xenopus laevis (African clawed frog) 500 78.00% Xenopus tropicalis (Western clawed frog) LOC100036940 ARP36575_P050 Q640T3_XENTR Annexin A5 (MGC89158 protein) (Silurana tropicalis) 323 78.00% E3 ubiquitin‐protein ligase ZNRF1 (EC 6.3.2.‐) ARP39690_P050 ZNRF1_XENLA (Zinc/RING finger protein 1) Xenopus laevis (African clawed frog) 195 85.00% EG:171D11.1 ARP46619_P050 Q498F4_XENLA LOC734217 protein (Fragment) Xenopus laevis (African clawed frog) 521 92.00% EG:171D11.1 ARP46619_P050 Q2VPL8_XENLA MGC131189 protein Xenopus laevis (African clawed frog) 523 92.00% Rab5b ARP56499_P050 Q6NU64_XENLA MGC81204 protein Xenopus laevis (African clawed frog) 185 78.00% Xenopus tropicalis (Western clawed frog) Rab5b ARP56499_P050 Q6DJ60_XENTR RAB5B, member RAS oncogene family (Silurana tropicalis) 215 78.00%

ORF Names:An14g00580 EMBL Queuine tRNA‐ribosyltransferase (EC 2.4.2.29) CAK41857.1OrganismAspergillus niger (Guanine insertion enzyme) (tRNA‐guanine Xenopus tropicalis (Western clawed frog) (strain CBS 513.88 / FGSC A1513) ARP48946_P050 TGT_XENTR transglycosylase) (Silurana tropicalis) 396 100.00%

ORF Names:An14g00580 EMBL Queuine tRNA‐ribosyltransferase (EC 2.4.2.29) CAK41857.1OrganismAspergillus niger (Guanine insertion enzyme) (tRNA‐guanine (strain CBS 513.88 / FGSC A1513) ARP48946_P050 TGT_XENLA transglycosylase) Xenopus laevis (African clawed frog) 396 100.00%

ORF Names:v1g184485OrganismNematostel Xenopus tropicalis (Western clawed frog) la vectensis (Starlet sea anemone) ARP48873_T100 B5DEC4_XENTR LOC733879 protein (Silurana tropicalis) 481 92.00% aldh18a1 ARP56216_P050 Q6GMF0_XENLA MGC81784 protein Xenopus laevis (African clawed frog) 815 85.00% Aldehyde dehydrogenase 18 family, member Xenopus tropicalis (Western clawed frog) aldh18a1 ARP56216_P050 Q28DF8_XENTR A1 (Silurana tropicalis) 796 85.00% Xenopus tropicalis (Western clawed frog) aldh18a1 ARP56216_P050 Q05AS6_XENTR Putative uncharacterized protein LOC550060 (Silurana tropicalis) 796 85.00% Mediator of RNA polymerase II transcription subunit 27 (Cofactor required for Sp1 transcriptional activation subunit 8) (CRSP complex subunit 8) (Mediator complex Xenopus tropicalis (Western clawed frog) Med27 ARP33743_P050 MED27_XENTR subunit 27) (Silurana tropicalis) 311 100.00%

Mediator of RNA polymerase II transcription subunit 27‐A (Cofactor required for Sp1 transcriptional activation subunit 8‐A) (CRSP complex subunit 8‐A) (Mediator complex Med27 ARP33743_P050 MD27A_XENLA subunit 27‐A) Xenopus laevis (African clawed frog) 311 100.00%

Mediator of RNA polymerase II transcription subunit 27‐B (Cofactor required for Sp1 transcriptional activation subunit 8‐B) (CRSP complex subunit 8‐B) (Mediator complex Med27 ARP33743_P050 MD27B_XENLA subunit 27‐B) Xenopus laevis (African clawed frog) 311 92.00% GALNT6 ARP46837_P050 Q2TAV9_XENLA Putative uncharacterized protein Xenopus laevis (African clawed frog) 622 85.00% Amt ARP54313_P050 Q0IH11_XENLA MGC154901 protein Xenopus laevis (African clawed frog) 404 84.00%

ORF Names:An05g00160 EMBL CAK44836.1OrganismAspergillus niger Xenopus tropicalis (Western clawed frog) (strain CBS 513.88 / FGSC A1513) ARP45746_T100 Q640V0_XENTR Cystathionine‐beta‐synthase (Silurana tropicalis) 562 100.00%

ORF Names:An05g00160 EMBL CAK44836.1OrganismAspergillus niger (strain CBS 513.88 / FGSC A1513) ARP45746_T100 Q7ZXW6_XENLA Cbs‐prov protein Xenopus laevis (African clawed frog) 565 92.00%

ORF Names:An05g00160 EMBL CAK44836.1OrganismAspergillus niger (strain CBS 513.88 / FGSC A1513) ARP45746_T100 Q6DDN9_XENLA Cbs‐prov protein Xenopus laevis (African clawed frog) 562 92.00% zbtb48 ARP58014_P050 A0AUT5_XENLA Zbtb48 protein Xenopus laevis (African clawed frog) 697 85.00% ARP43518_T100 Q7SZS3_XENLA Got2 protein Xenopus laevis (African clawed frog) 427 92.00% Aspartate aminotransferase, mitochondrial (mAspAT) (EC 2.6.1.1) (Glutamate oxaloacetate transaminase 2) (Transaminase Xenopus tropicalis (Western clawed frog) ARP43518_T100 AATM_XENTR A) (Silurana tropicalis) 427 92.00% Xenopus tropicalis (Western clawed frog) ARP37706_T100 B4F752_XENTR Putative uncharacterized protein (Silurana tropicalis) 237 92.00% ORF Names:ACLA_026630 EMBL EAW07946.1OrganismAspergillus clavatus ARP52697_P050 Q6PF46_XENLA MGC68931 protein Xenopus laevis (African clawed frog) 327 84.00% ORF Names:ACLA_026630 EMBL EAW07946.1OrganismAspergillus Xenopus tropicalis (Western clawed frog) clavatus ARP52697_P050 Q5BL76_XENTR Sept3 protein (Silurana tropicalis) 324 84.00% Cdc2‐prov protein (Cell division cycle 2, G1 to Xenopus tropicalis (Western clawed frog) CG5363 ARP58402_P050 Q6P7L3_XENTR S and G2 to M) (Silurana tropicalis) 302 100.00% CG5363 ARP58402_P050 Q6IRQ7_XENLA MGC81499 protein Xenopus laevis (African clawed frog) 297 100.00% Xenopus tropicalis (Western clawed frog) CG5363 ARP58402_P050 Q66IH7_XENTR MGC89594 protein (Silurana tropicalis) 297 100.00% Xenopus tropicalis (Western clawed frog) CG5363 ARP58402_P050 Q28FA6_XENTR Cell division cycle 2, G1 to S and G2 to M (Silurana tropicalis) 302 100.00%

CG5363 ARP58402_P050 B2L5U5_9PIPI Cell division control protein 2‐like (Fragment) Xenopus muelleri (Muller's clawed frog) 184 100.00% Cell division control protein 2‐like beta Xenopus (Silurana) epitropicalis (Cameroon CG5363 ARP58402_P050 B2L5S3_9PIPI (Fragment) clawed frog) 184 100.00% Cell division control protein 2‐like alpha CG5363 ARP58402_P050 B2L5S2_9PIPI (Fragment) Xenopus (Silurana) sp. new tetraploid 1 184 100.00% Cell division control protein 2‐like alpha Xenopus (Silurana) epitropicalis (Cameroon CG5363 ARP58402_P050 B2L5S1_9PIPI (Fragment) clawed frog) 184 100.00% Cell division control protein 2‐like protein 1 CG5363 ARP58402_P050 B2L431_XENBO (Fragment) Xenopus borealis (Kenyan clawed frog) 184 100.00% hagh ARP54515_P050 Q32NK6_XENLA MGC131075 protein Xenopus laevis (African clawed frog) 260 84.00% Xenopus tropicalis (Western clawed frog) hagh ARP54515_P050 GLO2_XENTR Isoform 2 (Silurana tropicalis) 260 84.00% Hydroxyacylglutathione hydrolase, mitochondrial (EC 3.1.2.6) (Glyoxalase II) (Glx Xenopus tropicalis (Western clawed frog) hagh ARP54515_P050 GLO2_XENTR II) (Silurana tropicalis) 313 84.00% LTC4S ARP49035_T100 Q5XGQ6_XENLA LOC495166 protein Xenopus laevis (African clawed frog) 140 76.00% Xenopus tropicalis (Western clawed frog) LTC4S ARP49035_T100 A9JSN8_XENTR LOC100127769 protein (Silurana tropicalis) 140 76.00% ARP39005_P050 Q6GNC6_XENLA MGC82887 protein Xenopus laevis (African clawed frog) 513 100.00% Xenopus tropicalis (Western clawed frog) ikzf1 ARP39005_P050 Q5FWQ9_XENTR IKAROS family zinc finger 1 (Ikaros) (Silurana tropicalis) 483 92.00% ikzf1 ARP39005_P050 Q5U246_XENLA LOC495690 protein Xenopus laevis (African clawed frog) 469 92.00% Xenopus tropicalis (Western clawed frog) ikzf1 ARP39005_P050 B1H2P4_XENTR Ikzf2 protein (Silurana tropicalis) 523 92.00%

ORF Names:v1g107937OrganismNematostel Xenopus tropicalis (Western clawed frog) la vectensis (Starlet sea anemone) ARP55100_P050 B5DE58_XENTR Putative uncharacterized protein (Silurana tropicalis) 319 100.00%

ORF Names:v1g229018OrganismNematostel Pre‐B‐cell leukemia transcription factor 2 Xenopus tropicalis (Western clawed frog) la vectensis (Starlet sea anemone) ARP47897_T100 PBX2_XENTR (Homeobox protein pbx2) (Silurana tropicalis) 422 92.00% ORF Names:v1g229018OrganismNematostel Pre‐B‐cell leukemia transcription factor 2 la vectensis (Starlet sea anemone) ARP47897_T100 PBX2_XENLA (Homeobox protein pbx2) Xenopus laevis (African clawed frog) 445 92.00%

ORF Names:v1g229018OrganismNematostel Pre‐B‐cell leukemia transcription factor 1 Xenopus tropicalis (Western clawed frog) la vectensis (Starlet sea anemone) ARP47897_T100 PBX1_XENTR (Homeobox protein ) (Silurana tropicalis) 347 92.00%

ORF Pre‐B‐cell leukemia transcription factor 1 Names:v1g229018OrganismNematostel (Xpbx1) (Homeobox protein pbx1) (Pre‐B‐cell la vectensis (Starlet sea anemone) ARP47897_T100 PBX1_XENLA leukemia transcription factor 1b) (Xpbx1b) Xenopus laevis (African clawed frog) 347 92.00% DNAJC1 ARP49712_P050 Q6GNU7_XENLA MGC80867 protein Xenopus laevis (African clawed frog) 534 100.00% DnaJ (Hsp40) homolog, subfamily C, member Xenopus tropicalis (Western clawed frog) DNAJC1 ARP49712_P050 Q5M7Q4_XENTR 1 (Silurana tropicalis) 535 100.00% Xenopus tropicalis (Western clawed frog) BGN ARP56333_P050 Q0P4I3_XENTR Putative uncharacterized protein MGC147411 (Silurana tropicalis) 369 83.00% BGN ARP56333_P050 Q6GLQ6_XENLA MGC84390 protein Xenopus laevis (African clawed frog) 371 83.00% BGN ARP56333_P050 B7FEW6_XENLA BGN protein Xenopus laevis (African clawed frog) 368 83.00% BGN ARP56333_P050 PGS1_XENLA Biglycan Xenopus laevis (African clawed frog) 368 83.00% Kcnma1 ARP35092_P050 KCMA1_XENLA Isoform 5 (Isoform xSlo99) Xenopus laevis (African clawed frog) 1295 100.00% Kcnma1 ARP35092_P050 KCMA1_XENLA Isoform 4 (Isoform xSlo59) Xenopus laevis (African clawed frog) 1252 100.00% Kcnma1 ARP35092_P050 KCMA1_XENLA Isoform 3 (Isoform xSlo56) Xenopus laevis (African clawed frog) 1255 100.00% Kcnma1 ARP35092_P050 KCMA1_XENLA Isoform 2 (Isoform xSlo15) Xenopus laevis (African clawed frog) 1211 100.00%

Calcium‐activated potassium channel subunit alpha‐1 (BK channel) (BKCA alpha) (Calcium‐ activated potassium channel, subfamily M subunit alpha‐1) (K(VCA)alpha) (KCa1.1) (Maxi K channel) (MaxiK) (Slo‐alpha) (Slo1) Kcnma1 ARP35092_P050 KCMA1_XENLA (Slowpoke homolog) (Slo homolog) (xSlo) Xenopus laevis (African clawed frog) 1196 100.00% ARP34713_T100 Q2NLA4_XENLA MGC131274 protein Xenopus laevis (African clawed frog) 259 78.00% Xenopus tropicalis (Western clawed frog) ARP34713_T100 B1H3E7_XENTR LOC100145610 protein (Silurana tropicalis) 259 78.00% nova2 ARP40400_T100 Q6GM36_XENLA MGC84002 protein Xenopus laevis (African clawed frog) 484 90.00% Xenopus tropicalis (Western clawed frog) nova2 ARP40400_T100 A4II03_XENTR LOC100124925 protein (Silurana tropicalis) 508 90.00% GF14670 ARP38403_T100 Q6DCJ5_XENLA TIMELESS protein (Fragment) Xenopus laevis (African clawed frog) 883 92.00% GF14670 ARP38403_T100 Q3LGB9_XENLA XTimeless1 Xenopus laevis (African clawed frog) 1286 92.00% Xenopus tropicalis (Western clawed frog) Prdm9 ARP39647_P050 B3DLU5_XENTR LOC100170545 protein (Silurana tropicalis) 302 90.00% Xenopus tropicalis (Western clawed frog) Prdm9 ARP39647_P050 Q28D94_XENTR Novel zinc finger protein (Silurana tropicalis) 581 75.00% Xenopus tropicalis (Western clawed frog) Prdm9 ARP39647_P050 Q28GY2_XENTR Novel zinc finger protein (Silurana tropicalis) 421 81.00% Xenopus tropicalis (Western clawed frog) Prdm9 ARP39647_P050 B2RZE9_XENTR Putative uncharacterized protein LOC549148 (Silurana tropicalis) 410 81.00%

NR5A2 ARP31833_P050 Q91545_XENLA Ftz‐F1‐related orphan receptor B (Fragment) Xenopus laevis (African clawed frog) 468 100.00% Nuclear receptor subfamily 5, group A, Xenopus tropicalis (Western clawed frog) NR5A2 ARP31833_P050 Q5XGE7_XENTR member 2 (Silurana tropicalis) 501 100.00% FTZ‐F1‐related nuclear orphan receptor NR5A2 ARP31833_P050 Q91601_XENLA variant Xenopus laevis (African clawed frog) 333 92.00% NR5A2 ARP31833_P050 Q91544_XENLA Ftz‐F1‐related orphan receptor A Xenopus laevis (African clawed frog) 501 92.00% FTZ‐F1‐related nuclear orphan receptor NR5A2 ARP31833_P050 B7ZQD9_XENLA variant Xenopus laevis (African clawed frog) 501 92.00% NR5A2 ARP31833_P050 B7ZQD7_XENLA Xff1rashort protein Xenopus laevis (African clawed frog) 501 92.00% ARP48000_P050 Q9W745_XENLA COUP transcription factor 1 Xenopus laevis (African clawed frog) 411 100.00% ARP48000_P050 Q6DCH6_XENLA Nr2f2 protein Xenopus laevis (African clawed frog) 404 100.00% Xenopus tropicalis (Western clawed frog) ARP48000_P050 A4QNF4_XENTR Nr2f1 protein (Silurana tropicalis) 410 100.00% ARP48000_P050 Q7ZXI7_XENLA Nr2f2 protein Xenopus laevis (African clawed frog) 405 85.00% Xenopus tropicalis (Western clawed frog) ARP48000_P050 A9ULC1_XENTR Nr2f2 protein (Silurana tropicalis) 408 85.00% ARP48000_P050 Q7T0T7_XENLA Nr2f6 protein Xenopus laevis (African clawed frog) 389 76.00% Nuclear receptor subfamily 2, group F, Xenopus tropicalis (Western clawed frog) ARP48000_P050 Q6GL59_XENTR member 6 (Silurana tropicalis) 389 76.00% Xenopus tropicalis (Western clawed frog) LOC100145021 ARP53761_P050 B0BMD4_XENTR LOC100145021 protein (Silurana tropicalis) 213 85.00% Eukaryotic translation initiation factor 3 subunit E (eIF3e) (Eukaryotic translation Xenopus tropicalis (Western clawed frog) ARP48175_P050 EIF3E_XENTR initiation factor 3 subunit 6) (Silurana tropicalis) 446 91.00%

Eukaryotic translation initiation factor 3 subunit E‐B (eIF3e‐B) (Eukaryotic translation ARP48175_P050 EI3EB_XENLA initiation factor 3 subunit 6‐B) Xenopus laevis (African clawed frog) 446 83.00%

Eukaryotic translation initiation factor 3 subunit E‐A (eIF3e‐A) (Eukaryotic translation ARP48175_P050 EI3EA_XENLA initiation factor 3 subunit 6‐A) Xenopus laevis (African clawed frog) 446 83.00% TRABD ARP42647_T100 Q5EAZ4_XENLA MGC84987 protein Xenopus laevis (African clawed frog) 373 78.00% Xenopus tropicalis (Western clawed frog) TRABD ARP42647_T100 B1H376_XENTR LOC100145566 protein (Silurana tropicalis) 367 78.00% Ordered Locus Names:MSMEG_0327OrganismMycoba 10‐formyltetrahydrofolate dehydrogenase (10‐ cterium smegmatis (strain ATCC FTHFDH) (EC 1.5.1.6) (Aldehyde Xenopus tropicalis (Western clawed frog) 700084 / mc(2)155) ARP52331_P050 FTHFD_XENTR dehydrogenase family 1 member L1) (Silurana tropicalis) 902 100.00% Ordered Locus Names:MSMEG_0327OrganismMycoba 10‐formyltetrahydrofolate dehydrogenase (10‐ cterium smegmatis (strain ATCC FTHFDH) (EC 1.5.1.6) (Aldehyde 700084 / mc(2)155) ARP52331_P050 FTHFD_XENLA dehydrogenase family 1 member L1) Xenopus laevis (African clawed frog) 902 100.00% Xenopus tropicalis (Western clawed frog) Ahcy ARP51768_P050 Q28IH7_XENTR S‐adenosylhomocysteine hydrolase (Silurana tropicalis) 433 85.00% Adenosylhomocysteinase B (AdoHcyase B) (EC 3.3.1.1) (S‐adenosyl‐L‐homocysteine Ahcy ARP51768_P050 SAHHB_XENLA hydrolase B) Xenopus laevis (African clawed frog) 433 85.00% Adenosylhomocysteinase A (AdoHcyase A) (EC 3.3.1.1) (S‐adenosyl‐L‐homocysteine Ahcy ARP51768_P050 SAHHA_XENLA hydrolase A) Xenopus laevis (African clawed frog) 433 85.00% ARP41463_T100 Q6DD73_XENLA MGC79035 protein Xenopus laevis (African clawed frog) 894 100.00% ARP41463_T100 Q6IP14_XENLA MGC79034 protein Xenopus laevis (African clawed frog) 894 92.00% Xenopus tropicalis (Western clawed frog) ARP41463_T100 Q6DF05_XENTR Actinin, alpha 2 (Silurana tropicalis) 894 92.00% Xenopus tropicalis (Western clawed frog) ARP41463_T100 B4F6M1_XENTR Putative uncharacterized protein (Silurana tropicalis) 896 78.00% Xenopus tropicalis (Western clawed frog) ARP55761_P050 TBB5_XENTR Tubulin beta chain (Tubulin beta‐5 chain) (Silurana tropicalis) 444 100.00%

ARP55761_P050 TBB5_XENLA Tubulin beta chain (Tubulin beta‐5 chain) Xenopus laevis (African clawed frog) 444 100.00% Xenopus tropicalis (Western clawed frog) ARP55761_P050 Q6P1T8_XENTR Tubulin, beta 3 (Silurana tropicalis) 449 92.00% ARP55761_P050 Q5U5A4_XENLA LOC495319 protein Xenopus laevis (African clawed frog) 449 92.00% ARP55761_P050 Q7ZY50_XENLA MGC53997 protein Xenopus laevis (African clawed frog) 445 85.00% ARP55761_P050 Q7ZWP4_XENLA MGC53205 protein Xenopus laevis (African clawed frog) 444 85.00% Xenopus tropicalis (Western clawed frog) ARP55761_P050 Q6P367_XENTR Tubulin, beta 2B (Silurana tropicalis) 445 85.00% Xenopus tropicalis (Western clawed frog) ARP55761_P050 Q5BL39_XENTR Tubulin, beta 2 (Tubulin, beta 4) (Silurana tropicalis) 444 85.00% Xenopus tropicalis (Western clawed frog) ARP55761_P050 Q0IIR4_XENTR Tubulin, beta 2C (Silurana tropicalis) 445 85.00% PCOLCE ARP56378_P050 Q66IT1_XENLA MGC84811 protein Xenopus laevis (African clawed frog) 480 85.00% Xenopus tropicalis (Western clawed frog) PCOLCE ARP56378_P050 Q66IF4_XENTR MGC89941 protein (Silurana tropicalis) 470 85.00% Xenopus tropicalis (Western clawed frog) PCOLCE ARP56378_P050 Q5CZL0_XENTR Putative uncharacterized protein (Silurana tropicalis) 470 85.00% PCOLCE ARP56378_P050 Q7ZWR8_XENLA MGC64292 protein (Fragment) Xenopus laevis (African clawed frog) 487 78.00% PCOLCE ARP56378_P050 Q7SY99_XENLA MGC64292 protein Xenopus laevis (African clawed frog) 450 78.00% Xenopus tropicalis (Western clawed frog) ESC1 ARP39844_P050 Q66IK5_XENTR Max protein (Silurana tropicalis) 127 100.00% ESC1 ARP39844_P050 MAX_XENLA Isoform XMAX3 Xenopus laevis (African clawed frog) 154 100.00% ESC1 ARP39844_P050 MAX_XENLA Isoform XMAX1 Xenopus laevis (African clawed frog) 127 100.00% ESC1 ARP39844_P050 Q6NRN6_XENLA XMax2 protein Xenopus laevis (African clawed frog) 136 92.00% Xenopus tropicalis (Western clawed frog) ESC1 ARP39844_P050 Q28BK0_XENTR MYC associated factor X (Silurana tropicalis) 136 92.00% ESC1 ARP39844_P050 B7ZPF6_XENLA Myc binding protein Xmax4 Xenopus laevis (African clawed frog) 163 92.00% ESC1 ARP39844_P050 MAX_XENLA Isoform XMAX2 (Isoform XMAX1) Xenopus laevis (African clawed frog) 136 92.00%

ESC1 ARP39844_P050 MAX_XENLA Protein (xMAX) (Myc‐associated factor X) Xenopus laevis (African clawed frog) 163 92.00% Xenopus tropicalis (Western clawed frog) WNT2 ARP32124_P050 A4GWY9_XENTR Wnt2 (Fragment) (Silurana tropicalis) 239 85.00% CNOT6 ARP40812_P050 Q32NW8_XENLA MGC130673 protein Xenopus laevis (African clawed frog) 414 85.00% Xenopus tropicalis (Western clawed frog) CNOT6 ARP40812_P050 B1H2X8_XENTR LOC100145505 protein (Silurana tropicalis) 523 85.00% CCR4‐NOT transcription complex subunit 6‐ CNOT6 ARP40812_P050 CN6LB_XENLA like‐B Xenopus laevis (African clawed frog) 550 85.00% CCR4‐NOT transcription complex subunit 6‐ CNOT6 ARP40812_P050 CN6LA_XENLA like‐A (EC 3.1.‐.‐) Xenopus laevis (African clawed frog) 550 85.00% CCR4‐NOT transcription complex subunit 6 (EC CNOT6 ARP40812_P050 CNOT6_XENLA 3.1.‐.‐) (Cytoplasmic deadenylase) Xenopus laevis (African clawed frog) 552 92.00% Xenopus tropicalis (Western clawed frog) CNOT6 ARP40812_P050 Q6P1V2_XENTR Putative uncharacterized protein MGC75617 (Silurana tropicalis) 524 76.00%

ORF Names:wu:fd12d03 ZFIN ZDB‐ GENE‐030131‐4532OrganismDanio rerio (Zebrafish) (Brachydanio rerio) ARP34372_P050 Q7ZWN3_XENLA B230399n07 protein Xenopus laevis (African clawed frog) 1893 100.00%

ORF Names:wu:fd12d03 ZFIN ZDB‐ GENE‐030131‐4532OrganismDanio Xenopus tropicalis (Western clawed frog) rerio (Zebrafish) (Brachydanio rerio) ARP34372_P050 A3KN93_XENTR Chd4 protein (Silurana tropicalis) 1888 100.00% ARP40528_T100 Q6GPZ8_XENLA LOC443599 protein (Fragment) Xenopus laevis (African clawed frog) 304 85.00% Splicing factor, arginine/serine‐rich 10 Xenopus tropicalis (Western clawed frog) ARP40528_T100 Q6DES6_XENTR (Transformer 2 homolog) (Silurana tropicalis) 293 85.00% ARP40528_T100 Q7ZTM8_XENLA LOC398448 protein (Fragment) Xenopus laevis (African clawed frog) 306 85.00% ARP40528_T100 Q2VPF1_XENLA LOC398448 protein Xenopus laevis (African clawed frog) 298 85.00% edc4 ARP55023_P050 EDC4_XENLA Enhancer of mRNA‐decapping protein 4 Xenopus laevis (African clawed frog) 1391 84.00% Transcription factor Sox‐6 (SRY (sex Xenopus tropicalis (Western clawed frog) ARP39760_P050 SOX6_XENTR determining region Y)‐box 6) (Silurana tropicalis) 777 85.00% Rnf135 ARP44817_P050 Q08AW2_XENLA Mitochondrial Rho GTPase (EC 3.6.5.‐) Xenopus laevis (African clawed frog) 618 92.00% Mitochondrial Rho GTPase 2 (MIRO‐2) (EC Xenopus tropicalis (Western clawed frog) Rnf135 ARP44817_P050 MIRO2_XENTR 3.6.5.‐) (Ras homolog gene family member T2) (Silurana tropicalis) 616 84.00% Fast skeletal muscle beta‐tropomyosin Tpm3 ARP48224_T100 Q91706_XENLA (Putative uncharacterized protein) Xenopus laevis (African clawed frog) 284 100.00% Tpm3 ARP48224_T100 Q7SZ31_XENLA MGC64279 protein Xenopus laevis (African clawed frog) 284 92.00% Tpm3 ARP48224_T100 Q91726_XENLA Cardiac tropomyosin Xenopus laevis (African clawed frog) 284 85.00% Tpm3 ARP48224_T100 Q6QJD0_XENLA Alpha fast tropomyosin (Fragment) Xenopus laevis (African clawed frog) 71 78.00% Tpm3 ARP48224_T100 O73681_XENLA Alpha‐tropomyosin Xenopus laevis (African clawed frog) 248 78.00% Xenopus tropicalis (Western clawed frog) Tpm3 ARP48224_T100 B0BMH6_XENTR Tpm1 protein (Silurana tropicalis) 284 78.00% Tpm3 ARP48224_T100 Q6QJD1_XENLA Alpha fast tropomyosin (Fragment) Xenopus laevis (African clawed frog) 71 84.00% Tpm3 ARP48224_T100 Q6IP24_XENLA Putative uncharacterized protein Xenopus laevis (African clawed frog) 284 84.00% Xenopus tropicalis (Western clawed frog) Tpm3 ARP48224_T100 B1H2X3_XENTR Tpm1 protein (Silurana tropicalis) 284 84.00% Xenopus tropicalis (Western clawed frog) Tpm3 ARP48224_T100 A9JSN1_XENTR LOC100127765 protein (Fragment) (Silurana tropicalis) 177 84.00% Tropomyosin alpha‐1 chain (Alpha‐ Tpm3 ARP48224_T100 TPM1_XENLA tropomyosin) (Tropomyosin‐1) Xenopus laevis (African clawed frog) 284 84.00%

ORF Names:v1g93174OrganismNematostell Xenopus tropicalis (Western clawed frog) a vectensis (Starlet sea anemone) ARP50539_P050 B1H2B9_XENTR LOC100145381 protein (Silurana tropicalis) 379 100.00%

ORF Names:v1g93174OrganismNematostell a vectensis (Starlet sea anemone) ARP50539_P050 Q8AVX0_XENLA Nprl2‐pending‐prov protein Xenopus laevis (African clawed frog) 378 85.00%

ORF Names:v1g93174OrganismNematostell Xenopus tropicalis (Western clawed frog) a vectensis (Starlet sea anemone) ARP50539_P050 Q6DIE1_XENTR Tumor suppressor candidate 4 (Silurana tropicalis) 378 85.00% hnrnpl2 ARP40367_T100 Q9W6R9_XENLA RNA‐binding protein XlhnRNPL (Fragment) Xenopus laevis (African clawed frog) 273 91.00% hnrnpl2 ARP40367_T100 Q6DDP7_XENLA Putative uncharacterized protein Xenopus laevis (African clawed frog) 538 91.00% Xenopus tropicalis (Western clawed frog) hnrnpl2 ARP40367_T100 A4QNC9_XENTR Hnrpl protein (Silurana tropicalis) 538 91.00% Xenopus tropicalis (Western clawed frog) notch1b ARP39295_P050 A2RUV0_XENTR Notch1 protein (Silurana tropicalis) 2522 85.00% Neurogenic locus notch protein homolog notch1b ARP39295_P050 NOTCH_XENLA (xOTCH) Xenopus laevis (African clawed frog) 2524 85.00% ORF Names:v1g125073OrganismNematostel la vectensis (Starlet sea anemone) ARP54267_P050 Q6GR40_XENLA Atg5 protein Xenopus laevis (African clawed frog) 306 100.00%

ORF Names:v1g125073OrganismNematostel la vectensis (Starlet sea anemone) ARP54267_P050 Q3MQ02_XENLA Autophagy protein 5 Xenopus laevis (African clawed frog) 276 100.00%

ORF Names:v1g125073OrganismNematostel Xenopus tropicalis (Western clawed frog) la vectensis (Starlet sea anemone) ARP54267_P050 B1WB05_XENTR Apg5l protein (Silurana tropicalis) 275 100.00% Xenopus tropicalis (Western clawed frog) UGT8 ARP45462_P050 Q0IJ22_XENTR LOC779534 protein (Fragment) (Silurana tropicalis) 185 91.00% Protein kinase, cAMP dependent regulatory, Xenopus tropicalis (Western clawed frog) Prkar1a ARP56420_P050 Q0P4Y3_XENTR type I beta (Silurana tropicalis) 380 100.00% Prkar1a ARP56420_P050 Q6INK7_XENLA Prkar1a protein Xenopus laevis (African clawed frog) 381 84.00% Prkar1a ARP56420_P050 Q6DJJ2_XENLA MGC82149 protein Xenopus laevis (African clawed frog) 381 84.00%

Protein kinase, cAMP‐dependent, regulatory, Xenopus tropicalis (Western clawed frog) Prkar1a ARP56420_P050 Q5BL84_XENTR type I, alpha (Tissue specific extinguisher 1) (Silurana tropicalis) 381 84.00% PGAM2 ARP48138_P050 Q640Y4_XENLA MGC84250 protein Xenopus laevis (African clawed frog) 253 85.00% Xenopus tropicalis (Western clawed frog) PGAM2 ARP48138_P050 A9UME8_XENTR LOC100135332 protein (Silurana tropicalis) 227 85.00% PGAM2 ARP48138_P050 Q7SYX4_XENLA Pgam2‐prov protein Xenopus laevis (African clawed frog) 253 78.00% Xenopus tropicalis (Western clawed frog) PGAM2 ARP48138_P050 Q6GL24_XENTR Phosphoglycerate mutase 1 (Brain) (Silurana tropicalis) 253 78.00% Protein phosphatase 2C alpha isoform (EC ppm1ab ARP57765_P050 Q8QFR1_XENLA 3.1.3.16) Xenopus laevis (African clawed frog) 383 100.00% ppm1ab ARP57765_P050 Q8AVG2_XENLA Ppm1a‐prov protein Xenopus laevis (African clawed frog) 383 100.00% Protein phosphatase 1A (Formerly 2C), Xenopus tropicalis (Western clawed frog) ppm1ab ARP57765_P050 Q28FK0_XENTR magnesium‐dependent, alpha isoform (Silurana tropicalis) 325 100.00% Xenopus tropicalis (Western clawed frog) ppm1ab ARP57765_P050 A4IHV9_XENTR Ppm1a protein (Silurana tropicalis) 383 100.00%

ORF Names:34864OrganismMonosiga brevicollis (Choanoflagellate) ARP54276_P050 Q7T0Y5_XENLA Acads protein Xenopus laevis (African clawed frog) 409 100.00%

ORF Names:34864OrganismMonosiga Acyl‐Coenzyme A dehydrogenase, C‐2 to C‐3 Xenopus tropicalis (Western clawed frog) brevicollis (Choanoflagellate) ARP54276_P050 Q6P324_XENTR short chain (Silurana tropicalis) 409 100.00% ORF Names:PANDA_013039 EMBL EFB29042.1OrganismAiluropoda Xenopus tropicalis (Western clawed frog) melanoleuca (Giant panda) ARP39205_P050 Q0P4L0_XENTR Putative uncharacterized protein MGC147120 (Silurana tropicalis) 500 76.00% fusA ARP39890_T100 Q6INS6_XENLA MGC81065 protein Xenopus laevis (African clawed frog) 655 78.00% LOC100135162 protein (Putative Xenopus tropicalis (Western clawed frog) pura ARP33201_P050 A9UL75_XENTR uncharacterized protein LOC100135162) (Silurana tropicalis) 282 84.00% lcp1 ARP54686_P050 Q7T0S8_XENLA Lcp1‐prov protein Xenopus laevis (African clawed frog) 616 92.00% LCP1 lymphocyte cytosolic protein 1 Xenopus tropicalis (Western clawed frog) lcp1 ARP54686_P050 Q5FW28_XENTR (MGC107867 protein) (Silurana tropicalis) 627 92.00% lcp1 ARP54686_P050 Q6P7I8_XENLA MGC68681 protein Xenopus laevis (African clawed frog) 629 85.00% Xenopus tropicalis (Western clawed frog) lcp1 ARP54686_P050 Q504Q2_XENTR Plastin 3 (T isoform) (Silurana tropicalis) 629 85.00%

Cysteinyl‐tRNA synthetase, cytoplasmic (EC Xenopus tropicalis (Western clawed frog) CARS ARP40294_P050 SYCC_XENTR 6.1.1.16) (Cysteine‐‐tRNA ligase) (CysRS) (Silurana tropicalis) 747 83.00%

Cysteinyl‐tRNA synthetase, cytoplasmic (EC CARS ARP40294_P050 SYCC_XENLA 6.1.1.16) (Cysteine‐‐tRNA ligase) (CysRS) Xenopus laevis (African clawed frog) 747 83.00% Microphthalmia associated transcription Tcfe3 ARP33439_P050 Q804B9_XENLA factor type A (Fragment) Xenopus laevis (African clawed frog) 208 84.00% Micophthalmia‐associated transcription factor Tcfe3 ARP33439_P050 Q76DN4_XENLA type A Xenopus laevis (African clawed frog) 483 84.00% ORF Names:OsI_13361 EMBL EAY91719.1OrganismOryza sativa subsp. indica (Rice) ARP53649_P050 Q7ZYU9_XENLA Alphatub84b‐prov protein Xenopus laevis (African clawed frog) 452 100.00% ORF Names:OsI_13361 EMBL EAY91719.1OrganismOryza sativa subsp. indica (Rice) ARP53649_P050 Q7ZWQ5_XENLA Tuba6‐prov protein Xenopus laevis (African clawed frog) 449 100.00% ORF Names:OsI_13361 EMBL EAY91719.1OrganismOryza sativa subsp. indica (Rice) ARP53649_P050 Q7ZTP0_XENLA MGC53359 protein Xenopus laevis (African clawed frog) 450 100.00% ORF Names:OsI_13361 EMBL EAY91719.1OrganismOryza sativa Xenopus tropicalis (Western clawed frog) subsp. indica (Rice) ARP53649_P050 Q6P8G7_XENTR Tubulin, alpha 1c (Tubulin, alpha 6) (Silurana tropicalis) 449 100.00% ORF Names:OsI_13361 EMBL EAY91719.1OrganismOryza sativa Xenopus tropicalis (Western clawed frog) subsp. indica (Rice) ARP53649_P050 Q6P8D2_XENTR Tubulin, alpha 1 (Silurana tropicalis) 451 100.00% ORF Names:OsI_13361 EMBL EAY91719.1OrganismOryza sativa subsp. indica (Rice) ARP53649_P050 Q6DD58_XENLA Mec‐12 protein Xenopus laevis (African clawed frog) 448 100.00% ORF Names:OsI_13361 EMBL EAY91719.1OrganismOryza sativa Novel protein similar to tubulin, alpha 1 Xenopus tropicalis (Western clawed frog) subsp. indica (Rice) ARP53649_P050 Q28CH9_XENTR (Tuba1) (Silurana tropicalis) 414 100.00% ORF Names:OsI_13361 EMBL EAY91719.1OrganismOryza sativa Novel protein similar to tubulin, alpha 1 Xenopus tropicalis (Western clawed frog) subsp. indica (Rice) ARP53649_P050 Q28C42_XENTR (Tuba1) (Silurana tropicalis) 449 100.00% ORF Names:OsI_13361 EMBL EAY91719.1OrganismOryza sativa Xenopus tropicalis (Western clawed frog) subsp. indica (Rice) ARP53649_P050 B7ZTG2_XENTR Tubulin, alpha 4b (Silurana tropicalis) 449 100.00% ORF Names:OsI_13361 EMBL EAY91719.1OrganismOryza sativa Xenopus tropicalis (Western clawed frog) subsp. indica (Rice) ARP53649_P050 B0JZX5_XENTR Putative uncharacterized protein (Silurana tropicalis) 145 100.00% ORF Names:OsI_13361 EMBL EAY91719.1OrganismOryza sativa Xenopus tropicalis (Western clawed frog) subsp. indica (Rice) ARP53649_P050 B0BMH2_XENTR Tuba4a protein (Silurana tropicalis) 451 100.00% ORF Names:OsI_13361 EMBL EAY91719.1OrganismOryza sativa Novel protein similar to tubulin, alpha 1 Xenopus tropicalis (Western clawed frog) subsp. indica (Rice) ARP53649_P050 A4IGU4_XENTR (Tuba1) (Silurana tropicalis) 449 100.00% ORF Names:OsI_13361 EMBL EAY91719.1OrganismOryza sativa subsp. indica (Rice) ARP53649_P050 A2RV72_XENLA LOC100037141 protein Xenopus laevis (African clawed frog) 449 100.00% Proliferator‐activated receptor gamma PPARGC1A ARP31507_P050 D7F2U5_XENLA coactivator 1 alpha (Fragment) Xenopus laevis (African clawed frog) 767 100.00% Xenopus tropicalis (Western clawed frog) ARP33285_P050 A6XEG9_XENTR Shox2 (Silurana tropicalis) 311 85.00% IRF6 ARP32670_P050 Q6DD26_XENLA Putative uncharacterized protein Xenopus laevis (African clawed frog) 460 91.00% Xenopus tropicalis (Western clawed frog) IRF6 ARP32670_P050 Q5BL51_XENTR Interferon regulatory factor 6, gene 2 (Silurana tropicalis) 365 91.00% IRF6 ARP32670_P050 Q2VPM3_XENLA XIRF‐6 protein Xenopus laevis (African clawed frog) 459 91.00% Novel protein similar to interferon regulatory Xenopus tropicalis (Western clawed frog) IRF6 ARP32670_P050 Q28ET3_XENTR factor transcription factor (Silurana tropicalis) 460 91.00% Novel protein similar to interferon regulatory Xenopus tropicalis (Western clawed frog) IRF6 ARP32670_P050 Q28ES2_XENTR factor transcription factor (Silurana tropicalis) 460 91.00% IRF6 ARP32670_P050 O57578_XENLA XIRF‐6 protein Xenopus laevis (African clawed frog) 459 91.00%

IRF6 ARP32670_P050 B2L4C7_XENBO Interferon regulatory factor 6 (Fragment) Xenopus borealis (Kenyan clawed frog) 32 91.00% Xenopus tropicalis (Western clawed frog) IRF6 ARP32670_P050 B0JZ05_XENTR Interferon regulatory factor 6 (Silurana tropicalis) 460 91.00% IRF6 ARP32670_P050 Q6GR23_XENLA MGC81304 protein Xenopus laevis (African clawed frog) 460 83.00% Exosc3 ARP40230_P050 Q58E93_XENLA MGC84934 protein Xenopus laevis (African clawed frog) 250 91.00% dlx2b ARP32867_P050 Q6GLJ3_XENLA Dlx5 protein Xenopus laevis (African clawed frog) 286 100.00% DLL3 (Distal‐less homeo box 5) (Distal‐less Xenopus tropicalis (Western clawed frog) dlx2b ARP32867_P050 Q6GLH9_XENTR homeobox 5) (Silurana tropicalis) 289 100.00% Xenopus tropicalis (Western clawed frog) dlx2b ARP32867_P050 Q66JE3_XENTR Distal‐less homeobox 2 (Silurana tropicalis) 285 100.00% dlx2b ARP32867_P050 DLL4_XENLA Homeobox protein DLL‐4 (XDLL‐4) Xenopus laevis (African clawed frog) 285 100.00% dlx2b ARP32867_P050 DLL3_XENLA Homeobox protein DLL‐3 (XDLL‐3) Xenopus laevis (African clawed frog) 289 100.00% dlx2b ARP32867_P050 Q6DD47_XENLA MGC80142 protein Xenopus laevis (African clawed frog) 279 92.00% Xenopus tropicalis (Western clawed frog) dlx2b ARP32867_P050 Q5BL47_XENTR Distal‐less homeobox 3 (Silurana tropicalis) 276 92.00% Xenopus tropicalis (Western clawed frog) dlx2b ARP32867_P050 Q28BP8_XENTR Distal‐less homeo box 3 (Silurana tropicalis) 277 92.00% dlx2b ARP32867_P050 Q1JQ72_XENLA Putative uncharacterized protein Xenopus laevis (African clawed frog) 274 92.00% dlx2b ARP32867_P050 Q06403_XENLA X‐DLL2 (Fragment) Xenopus laevis (African clawed frog) 266 92.00% dlx2b ARP32867_P050 DLL2_XENLA Homeobox protein DLL‐2 (XDLL‐2) Xenopus laevis (African clawed frog) 277 92.00% Xenopus tropicalis (Western clawed frog) TYR ARP44269_T100 A4QNF6_XENTR LOC100125152 protein (Silurana tropicalis) 531 91.00% Xenopus tropicalis (Western clawed frog) ARP49064_P050 A4IIJ1_XENTR Tmtc2 protein (Silurana tropicalis) 836 100.00% Transmembrane and TPR repeat‐containing tmtc2 ARP49064_P050 TMTC2_XENLA protein 2 Xenopus laevis (African clawed frog) 836 100.00% ARP32126_P050 WNT4_XENLA Isoform 2 Xenopus laevis (African clawed frog) 367 92.00% ARP32126_P050 WNT4_XENLA Protein Wnt‐4 (XWnt‐4) Xenopus laevis (African clawed frog) 351 92.00% srf P100866_T100 B7ZPQ5_XENLA Serum response factor Xenopus laevis (African clawed frog) 448 100.00% srf P100866_T100 SRF_XENLA Serum response factor (SRF) Xenopus laevis (African clawed frog) 448 100.00% Dnajb5 AVARP09012_T100 Q5XGX0_XENLA LOC495121 protein Xenopus laevis (African clawed frog) 348 100.00%

SALF ARP31514_T100 Q6XPY5_XENLA TFIIAa/b‐like factor (Transcription factor ALF) Xenopus laevis (African clawed frog) 472 92.00% SALF ARP31514_T100 Q6GMZ8_XENLA ALF protein Xenopus laevis (African clawed frog) 472 92.00% Xenopus tropicalis (Western clawed frog) SALF ARP31514_T100 Q28C10_XENTR TFIIA‐alpha/beta‐like factor (Silurana tropicalis) 472 92.00% Xenopus tropicalis (Western clawed frog) SALF ARP31514_T100 A9ULH8_XENTR General transcription factor IIA, 1‐like (Silurana tropicalis) 472 92.00% Xenopus tropicalis (Western clawed frog) Pacrg ARP52953_P050 A7MC44_XENTR LOC100127543 protein (Silurana tropicalis) 240 100.00% Xenopus tropicalis (Western clawed frog) ube2c ARP43090_P050 A0PJP2_XENTR Ube2c protein (Silurana tropicalis) 179 100.00% Ubiquitin‐conjugating enzyme E2 C (EC 6.3.2.19) (UBC‐X) (Ubiquitin carrier protein C) ube2c ARP43090_P050 UBE2C_XENLA (Ubiquitin‐protein ligase C) Xenopus laevis (African clawed frog) 179 100.00% ube2c ARP43090_P050 Q5I005_XENLA LOC496302 protein Xenopus laevis (African clawed frog) 179 92.00% Poly(A)‐specific ribonuclease (Deadenylation Xenopus tropicalis (Western clawed frog) ARP37393_T100 Q07G83_XENTR nuclease) (Fragment) (Silurana tropicalis) 519 92.00% Xenopus tropicalis (Western clawed frog) ARP37393_T100 B5DFR2_XENTR Putative uncharacterized protein (Fragment) (Silurana tropicalis) 525 92.00%

Poly(A)‐specific ribonuclease PARN (EC 3.1.13.4) (Deadenylating nuclease) (Deadenylation nuclease) (Polyadenylate‐ ARP37393_T100 PARN_XENLA specific ribonuclease) (parn‐A) Xenopus laevis (African clawed frog) 631 92.00% Ordered Locus Names:Shewana3_3614OrganismShew Cystathionase (Cystathionine gamma‐lyase) Xenopus tropicalis (Western clawed frog) anella sp. (strain ANA‐3) ARP46067_P050 Q6P849_XENTR (Putative uncharacterized protein MGC75946) (Silurana tropicalis) 398 92.00% Ordered Locus Names:Shewana3_3614OrganismShew anella sp. (strain ANA‐3) ARP46067_P050 Q640H4_XENLA LOC494673 protein Xenopus laevis (African clawed frog) 398 84.00% Xenopus tropicalis (Western clawed frog) ARP41753_P050 Q5FW21_XENTR MGC107878 protein (Silurana tropicalis) 464 80.00% SUMO‐conjugating enzyme UBC9 (EC 6.3.2.‐) (SUMO‐protein ligase) (Ubiquitin carrier protein 9) (Ubiquitin carrier protein I) (Ubiquitin‐conjugating enzyme E2 I) (Ubiquitin‐Xenopus tropicalis (Western clawed frog) UBE2I ARP43021_T100 UBC9_XENTR protein ligase I) (Silurana tropicalis) 158 100.00% SUMO‐conjugating enzyme UBC9 (EC 6.3.2.‐) (SUMO‐protein ligase) (Ubiquitin carrier protein 9) (Ubiquitin carrier protein I) (Ubiquitin‐conjugating enzyme E2 I) (Ubiquitin‐ UBE2I ARP43021_T100 UBC9_XENLA protein ligase I) Xenopus laevis (African clawed frog) 158 100.00% P100600_T100 Q63ZT4_XENLA Beta‐catenin protein Xenopus laevis (African clawed frog) 781 92.00% Catenin (Cadherin associated protein), beta 1, 88kDa (Catenin (Cadherin‐associated protein), Xenopus tropicalis (Western clawed frog) P100600_T100 Q28GC2_XENTR beta 1, 88kDa) (Silurana tropicalis) 781 92.00% P100600_T100 CTNB_XENLA Catenin beta (Beta‐catenin) Xenopus laevis (African clawed frog) 781 92.00% P100600_T100 Q7ZX35_XENLA Ctnnb1‐prov protein Xenopus laevis (African clawed frog) 781 83.00% P100600_T100 A1A5I6_XENLA Ctnnb1 protein Xenopus laevis (African clawed frog) 780 83.00% Down‐regulator of transcription 1, TBP‐ Xenopus tropicalis (Western clawed frog) NC2B ARP38085_T100 Q28BK2_XENTR binding (Negative cofactor 2) (Silurana tropicalis) 175 100.00% NC2B ARP38085_T100 O13068_9PIPI Dr1 Xenopus sp. (clawed frog) 175 92.00% LASS5 ARP36161_P050 Q8QGA3_XENLA TRH4 (TRH4 protein) Xenopus laevis (African clawed frog) 382 85.00% Xenopus tropicalis (Western clawed frog) LOC100125046 ARP49352_P050 A4IIR6_XENTR LOC100125046 protein (Fragment) (Silurana tropicalis) 923 83.00% ARP40427_T100 Q7ZYN0_XENLA Rbms1‐prov protein Xenopus laevis (African clawed frog) 374 92.00% Xenopus tropicalis (Western clawed frog) ARP40427_T100 Q0IIS2_XENTR LOC100036596 protein (Silurana tropicalis) 406 85.00% Xenopus tropicalis (Western clawed frog) ARP40427_T100 B4F6H4_XENTR LOC100036596 protein (Silurana tropicalis) 399 85.00%

ORF Names:v1g82503OrganismNematostell ERI1 exoribonuclease 2 (EC 3.1.‐.‐) a vectensis (Starlet sea anemone) ARP52509_P050 ERI2_XENLA (Exonuclease domain‐containing protein 1) Xenopus laevis (African clawed frog) 687 100.00% h2afx ARP58280_P050 Q6INC9_XENLA MGC83508 protein Xenopus laevis (African clawed frog) 126 92.00% Xenopus tropicalis (Western clawed frog) h2afx ARP58280_P050 Q28E74_XENTR Histone H2A (Silurana tropicalis) 143 92.00% h2afx ARP58280_P050 Q6AZS1_XENLA MGC82198 protein Xenopus laevis (African clawed frog) 130 85.00% h2afx ARP58280_P050 Q6AZJ8_XENLA LOC494591 protein Xenopus laevis (African clawed frog) 130 85.00% Xenopus tropicalis (Western clawed frog) h2afx ARP58280_P050 Q28F61_XENTR Histone 2, H2ab (Silurana tropicalis) 130 85.00% Xenopus tropicalis (Western clawed frog) h2afx ARP58280_P050 B0JZ06_XENTR LOC100145139 protein (Silurana tropicalis) 130 85.00% h2afx ARP58280_P050 H2A1_XENLA Histone H2A type 1 Xenopus laevis (African clawed frog) 130 85.00% H2A histone family, member J (MGC69325 Xenopus tropicalis (Western clawed frog) h2afx ARP58280_P050 Q6DK82_XENTR protein) (Silurana tropicalis) 130 85.00% PFDN6 ARP52345_P050 Q5U5B8_XENLA LOC495306 protein Xenopus laevis (African clawed frog) 126 92.00% HLA class II region expressed gene KE2 Xenopus tropicalis (Western clawed frog) PFDN6 ARP52345_P050 Q28CE5_XENTR (Prefoldin subunit 6) (Silurana tropicalis) 126 92.00% PFDN6 ARP52345_P050 Q0IH09_XENLA MGC154905 protein Xenopus laevis (African clawed frog) 126 92.00% Xenopus tropicalis (Western clawed frog) SOX9 P100797_T100 SOX9_XENTR Transcription factor Sox‐9 (Xt‐sox9) (Silurana tropicalis) 482 100.00% SOX9 P100797_T100 SOX9B_XENLA Transcription factor Sox‐9‐B Xenopus laevis (African clawed frog) 476 100.00% SOX9 P100797_T100 SOX9A_XENLA Transcription factor Sox‐9‐A Xenopus laevis (African clawed frog) 477 100.00% NUFIP2 ARP51676_P050 A2RV86_XENLA LOC100037153 protein Xenopus laevis (African clawed frog) 661 92.00% LOC100127335 protein (Putative ARP38973_P050 A9JS84_XENLA uncharacterized protein LOC100127335) Xenopus laevis (African clawed frog) 333 100.00% Xenopus tropicalis (Western clawed frog) ARP38973_P050 Q28DL7_XENTR RING1 and YY1 binding protein (Silurana tropicalis) 336 92.00%

XRCC5 ARP34121_T100 Q9W627_XENLA Ku80 autoantigen homologue (Fragment) Xenopus laevis (African clawed frog) 726 84.00% XRCC5 ARP34121_T100 Q6DDS9_XENLA Xrcc5‐A‐prov protein Xenopus laevis (African clawed frog) 726 84.00% ARP40918_P050 Q5U4T4_XENLA LOC495438 protein Xenopus laevis (African clawed frog) 699 84.00% Xenopus tropicalis (Western clawed frog) ARP40918_P050 A4IIV9_XENTR LOC100124739 protein (Silurana tropicalis) 719 84.00% Low molecular weight protein tyrosine ACP1 ARP42178_T100 Q8UWG5_XENLA phosphatase 1a Xenopus laevis (African clawed frog) 159 100.00% Abhydrolase domain‐containing protein Xenopus tropicalis (Western clawed frog) ARP56805_P050 F108B_XENTR FAM108B1 (EC 3.‐.‐.‐) (Silurana tropicalis) 288 85.00% Abhydrolase domain‐containing protein ARP56805_P050 F108B_XENLA FAM108B1 (EC 3.‐.‐.‐) Xenopus laevis (African clawed frog) 288 85.00% Abhydrolase domain‐containing protein Xenopus tropicalis (Western clawed frog) ARP56805_P050 F108C_XENTR FAM108C1 (EC 3.‐.‐.‐) (Silurana tropicalis) 310 85.00% Abhydrolase domain‐containing protein ARP56805_P050 F108C_XENLA FAM108C1 (EC 3.‐.‐.‐) Xenopus laevis (African clawed frog) 311 85.00% Xenopus tropicalis (Western clawed frog) ARP56805_P050 A9UMC4_XENTR LOC100135308 protein (Silurana tropicalis) 222 78.00% Xenopus tropicalis (Western clawed frog) ARP56805_P050 Q5M904_XENTR Hypothetical LOC496639 (Novel protein) (Silurana tropicalis) 305 78.00% ARP56805_P050 Q3KQ37_XENLA MGC131027 protein Xenopus laevis (African clawed frog) 305 78.00% LOC100127338 protein (Putative ARP56805_P050 A9JS88_XENLA uncharacterized protein LOC100127338) Xenopus laevis (African clawed frog) 305 78.00% slco2b1 ARP43926_P050 Q32NK1_XENLA MGC131084 protein Xenopus laevis (African clawed frog) 560 85.00% Xenopus tropicalis (Western clawed frog) slco2b1 ARP43926_P050 A4IIQ0_XENTR LOC100125037 protein (Silurana tropicalis) 655 85.00% Xenopus tropicalis (Western clawed frog) ARP47760_P050 MAFA_XENTR Transcription factor MafA (Silurana tropicalis) 289 85.00% Xenopus tropicalis (Western clawed frog) Cln6 ARP47371_P050 B1H0Z0_XENTR LOC100145280 protein (Silurana tropicalis) 301 85.00% Cln6 ARP47371_P050 A9JS93_XENLA LOC100127342 protein (Fragment) Xenopus laevis (African clawed frog) 298 85.00% TNNT1 ARP42120_P050 Q6DKC5_XENLA MGC84152 protein Xenopus laevis (African clawed frog) 265 92.00% hoxc5a ARP31389_P050 Q08B46_XENLA Hoxc5‐A protein Xenopus laevis (African clawed frog) 226 100.00% Homeobox protein Hox‐C5 (XlHbox‐5) hoxc5a ARP31389_P050 HXC5_XENLA (Fragment) Xenopus laevis (African clawed frog) 87 100.00%

Solute carrier family 22 member 6‐A (Organic cation transporter 1‐A) (Renal organic anion SLC22A20 ARP41549_P050 S226A_XENLA transporter 1‐A) (ROAT1‐A) Xenopus laevis (African clawed frog) 558 84.00%

ORF Names:v1g181605OrganismNematostel Xenopus tropicalis (Western clawed frog) la vectensis (Starlet sea anemone) ARP56487_P050 TWF1_XENTR Twinfilin‐1 (Silurana tropicalis) 350 100.00%

ORF Names:v1g181605OrganismNematostel la vectensis (Starlet sea anemone) ARP56487_P050 TWF1_XENLA Twinfilin‐1 Xenopus laevis (African clawed frog) 350 100.00% Peroxisome proliferator‐activated receptor Pparg ARP32880_T100 Q98SF8_XENLA gamma Xenopus laevis (African clawed frog) 477 90.00% Pparg ARP32880_T100 Q6PA31_XENLA PPARg protein Xenopus laevis (African clawed frog) 477 90.00%

Peroxisome proliferator‐activated receptor gamma (PPAR‐gamma) (Nuclear receptor Pparg ARP32880_T100 PPARG_XENLA subfamily 1 group C member 3) Xenopus laevis (African clawed frog) 477 90.00% ARP41399_T100 Q7ZY54_XENLA M(2)21ab protein Xenopus laevis (African clawed frog) 396 85.00% Xenopus tropicalis (Western clawed frog) ARP41399_T100 Q6P1T2_XENTR Methionine adenosyltransferase II, alpha (Silurana tropicalis) 396 85.00% Xenopus tropicalis (Western clawed frog) ARP41399_T100 Q66KL3_XENTR Methionine adenosyltransferase II, alpha (Silurana tropicalis) 396 85.00% ARP41399_T100 Q4KLX5_XENLA M(2)21ab‐prov protein Xenopus laevis (African clawed frog) 363 85.00% Xenopus tropicalis (Western clawed frog) ARP41399_T100 A9JTV0_XENTR LOC100127858 protein (Silurana tropicalis) 396 78.00% ARP52040_P050 Q7ZX19_XENLA Calponin 2 copy A (Cnn2‐prov protein) Xenopus laevis (African clawed frog) 294 100.00% Xenopus tropicalis (Western clawed frog) ARP52040_P050 Q6NVQ5_XENTR Calponin 2 (Silurana tropicalis) 295 100.00% ARP52040_P050 Q6GNN7_XENLA MGC80982 protein Xenopus laevis (African clawed frog) 295 100.00% ARP52040_P050 O93547_XENLA Calponin H3 Xenopus laevis (African clawed frog) 295 100.00% ARP52040_P050 A9CDP5_XENLA Calponin 2 copy B Xenopus laevis (African clawed frog) 295 100.00% OTTMUSG00000010173 ARP47748_P050 MYNN_XENLA Myoneurin Xenopus laevis (African clawed frog) 609 92.00% OTTMUSG00000010173 ARP47748_P050 Q5XGZ3_XENLA LOC495109 protein (Fragment) Xenopus laevis (African clawed frog) 637 91.00% OTTMUSG00000010173 ARP47748_P050 Q32N45_XENLA LOC495109 protein Xenopus laevis (African clawed frog) 658 91.00% Xenopus tropicalis (Western clawed frog) OTTMUSG00000010173 ARP47748_P050 Q5M7S6_XENTR Hypothetical LOC496795 (Silurana tropicalis) 516 91.00% Xenopus tropicalis (Western clawed frog) C2orf28 ARP30550_P050 Q5M8F4_XENTR RIKEN cDNA 0610007C21 gene (Silurana tropicalis) 164 76.00% C2orf28 ARP30550_P050 Q52L06_XENLA MGC115119 protein Xenopus laevis (African clawed frog) 223 76.00%

V‐rel reticuloendotheliosis viral oncogene REL P100756_P050 Q91833_XENLA homolog (Avian) (Xrel2 protein) Xenopus laevis (African clawed frog) 583 85.00% REL P100756_P050 B7ZRJ3_XENLA Rel3 protein Xenopus laevis (African clawed frog) 558 78.00% Xenopus tropicalis (Western clawed frog) REL P100756_P050 A4IIW1_XENTR Rel protein (Silurana tropicalis) 567 78.00%

ORF Names:v1g141685OrganismNematostel la vectensis (Starlet sea anemone) ARP54286_P050 Q6IR67_XENLA MGC82277 protein Xenopus laevis (African clawed frog) 456 84.00%

ORF Names:v1g141685OrganismNematostel Xenopus tropicalis (Western clawed frog) la vectensis (Starlet sea anemone) ARP54286_P050 B2GUB2_XENTR LOC100158543 protein (Silurana tropicalis) 457 84.00% Nr1h2 ARP33481_P050 Q6GMA2_XENLA MGC81974 protein Xenopus laevis (African clawed frog) 441 100.00% Nuclear receptor subfamily 1, group H, Xenopus tropicalis (Western clawed frog) Nr1h2 ARP33481_P050 Q0IHW4_XENTR member 2 (Silurana tropicalis) 441 100.00%

ORF Names:BRAFLDRAFT_96270 EMBL EEN43394.1OrganismBranchiostoma Ectoderm‐neural cortex protein 2 (Kelch‐like floridae (Florida lancelet) (Amphioxus) ARP34609_T100 ENC2_XENLA protein 25) Xenopus laevis (African clawed frog) 589 92.00%

ORF Names:BRAFLDRAFT_96270 EMBL EEN43394.1OrganismBranchiostoma Ectoderm‐neural cortex protein 2 (Kelch‐like Xenopus tropicalis (Western clawed frog) floridae (Florida lancelet) (Amphioxus) ARP34609_T100 ENC2_XENTR protein 25) (Silurana tropicalis) 589 85.00% ORF Names:RLO149_15013 EMBL EDQ16185.1OrganismRoseobacter Xenopus tropicalis (Western clawed frog) litoralis Och 149 ARP48630_T100 B5DE21_XENTR Putative uncharacterized protein (Silurana tropicalis) 416 92.00% ARP44799_P050 Q9YGK9_XENLA Lamina associated polypeptide 2 Xenopus laevis (African clawed frog) 518 91.00% ARP44799_P050 Q32N69_XENLA LAP2 protein Xenopus laevis (African clawed frog) 337 91.00% ARP44799_P050 Q7ZWN7_XENLA MGC53918 protein Xenopus laevis (African clawed frog) 206 100.00% Xenopus tropicalis (Western clawed frog) ARP44799_P050 Q6P846_XENTR Thymopoietin (Silurana tropicalis) 452 100.00%

ARP44799_P050 Q4LDN2_XENLA Lamina associated protein 2‐beta isoform Xenopus laevis (African clawed frog) 520 100.00%

Lamina associated protein 2‐beta isoform ARP44799_P050 O73766_XENLA (Lamina‐associated polypeptide 2 omega) Xenopus laevis (African clawed frog) 557 100.00%

Heterogeneous nuclear ribonucleoprotein D‐ Xenopus tropicalis (Western clawed frog) HNRPDL ARP40585_T100 HNRDL_XENTR like (hnRNP D‐like) (hnRNP DL) (Silurana tropicalis) 297 92.00%

Heterogeneous nuclear ribonucleoprotein D‐ HNRPDL ARP40585_T100 HNDLA_XENLA like‐A (hnRNP D‐like A) (hnRNP DL‐A) Xenopus laevis (African clawed frog) 293 92.00% Xenopus tropicalis (Western clawed frog) STK3 ARP48700_P050 A0JP92_XENTR LOC100036637 protein (Silurana tropicalis) 493 100.00% Serine/threonine‐protein kinase 3 (EC STK3 ARP48700_P050 STK3_XENLA 2.7.11.1) Xenopus laevis (African clawed frog) 493 100.00% STK3 ARP48700_P050 Q0IHG7_XENLA Stk4 protein Xenopus laevis (African clawed frog) 295 83.00% Serine/threonine‐protein kinase 4 (EC Xenopus tropicalis (Western clawed frog) STK3 ARP48700_P050 STK4_XENTR 2.7.11.1) (Silurana tropicalis) 485 83.00% Serine/threonine‐protein kinase 4 (EC STK3 ARP48700_P050 STK4_XENLA 2.7.11.1) Xenopus laevis (African clawed frog) 485 83.00% NEDD8‐conjugating enzyme UBE2F (EC 6.3.2.‐) (NEDD8 carrier protein UBE2F) (NEDD8 protein ligase UBE2F) (NEDD8‐conjugating enzyme 2) (Ubiquitin‐conjugating enzyme E2 Xenopus tropicalis (Western clawed frog) UBE2F ARP52515_P050 UBE2F_XENTR F) (Silurana tropicalis) 185 92.00% NEDD8‐conjugating enzyme UBE2F (EC 6.3.2.‐) (NEDD8 carrier protein UBE2F) (NEDD8 protein ligase UBE2F) (NEDD8‐conjugating enzyme 2) (Ubiquitin‐conjugating enzyme E2 UBE2F ARP52515_P050 UBE2F_XENLA F) Xenopus laevis (African clawed frog) 185 92.00% Hnrnpa3 ARP40282_T100 Q7ZX33_XENLA Hnrpa1 protein Xenopus laevis (African clawed frog) 399 84.00% Hnrnpa3 ARP40282_T100 Q6IP29_XENLA LOC397751 protein Xenopus laevis (African clawed frog) 365 76.00% Hnrnpa3 ARP40282_T100 ROA1_XENLA Isoform A1‐B Xenopus laevis (African clawed frog) 351 76.00%

Heterogeneous nuclear ribonucleoproteins A1 homolog (hnRNP A1) (Helix‐destabilizing protein) (Single‐strand‐binding protein) Hnrnpa3 ARP40282_T100 ROA1_XENLA (hnRNP core protein A1) Xenopus laevis (African clawed frog) 365 76.00% Hnrnpa3 ARP40282_T100 B7ZQP4_XENLA Putative uncharacterized protein Xenopus laevis (African clawed frog) 348 100.00% Xenopus tropicalis (Western clawed frog) Hnrnpa3 ARP40282_T100 B0BM91_XENTR LOC100144993 protein (Silurana tropicalis) 383 100.00%

Heterogeneous nuclear ribonucleoprotein A3 Hnrnpa3 ARP40282_T100 RO32_XENLA homolog 2 (hnRNP A3(B)) Xenopus laevis (African clawed frog) 385 100.00%

Heterogeneous nuclear ribonucleoprotein A3 Hnrnpa3 ARP40282_T100 RO31_XENLA homolog 1 (hnRNP A3(A)) Xenopus laevis (African clawed frog) 373 100.00% ARP33643_T100 B7ZPU9_XENLA Xlim‐3 protein Xenopus laevis (African clawed frog) 395 80.00%

LIM/homeobox protein Lhx3 (LIM homeobox ARP33643_T100 LHX3_XENLA protein 3) (Homeobox protein LIM‐3) (xLIM‐3) Xenopus laevis (African clawed frog) 395 80.00% MEIS1 ARP32017_P050 B7ZRS8_XENLA Meis1 protein Xenopus laevis (African clawed frog) 465 85.00% MEIS1 ARP32017_P050 MEIS1_XENLA Isoform 2 (Isoform XMeis1‐2) (Isoform b) Xenopus laevis (African clawed frog) 465 85.00% MEIS1 ARP32017_P050 MEIS1_XENLA Homeobox protein Meis1 (XMeis1) Xenopus laevis (African clawed frog) 390 85.00% ARP40383_T100 Q7ZX33_XENLA Hnrpa1 protein Xenopus laevis (African clawed frog) 399 92.00% ARP40383_T100 Q6IP29_XENLA LOC397751 protein Xenopus laevis (African clawed frog) 365 84.00% ARP40383_T100 ROA1_XENLA Isoform A1‐B Xenopus laevis (African clawed frog) 351 84.00%

Heterogeneous nuclear ribonucleoproteins A1 homolog (hnRNP A1) (Helix‐destabilizing protein) (Single‐strand‐binding protein) ARP40383_T100 ROA1_XENLA (hnRNP core protein A1) Xenopus laevis (African clawed frog) 365 84.00% ARP40383_T100 B7ZQP4_XENLA Putative uncharacterized protein Xenopus laevis (African clawed frog) 348 100.00% Xenopus tropicalis (Western clawed frog) ARP40383_T100 B0BM91_XENTR LOC100144993 protein (Silurana tropicalis) 383 100.00%

Heterogeneous nuclear ribonucleoprotein A3 ARP40383_T100 RO32_XENLA homolog 2 (hnRNP A3(B)) Xenopus laevis (African clawed frog) 385 100.00%

Heterogeneous nuclear ribonucleoprotein A3 ARP40383_T100 RO31_XENLA homolog 1 (hnRNP A3(A)) Xenopus laevis (African clawed frog) 373 100.00% RECO ARP34166_P050 Q6DJE7_XENLA MGC84424 protein Xenopus laevis (African clawed frog) 192 84.00% Xenopus tropicalis (Western clawed frog) RECO ARP34166_P050 Q641J1_XENTR MGC79749 protein (Silurana tropicalis) 193 84.00% RECO ARP34166_P050 Q68EX5_XENLA MGC84117 protein Xenopus laevis (African clawed frog) 192 84.00%

ZSCAN21 ARP39869_T100 ZO26_XENLA Oocyte zinc finger protein XlCOF26 (Fragment) Xenopus laevis (African clawed frog) 196 83.00% Xenopus tropicalis (Western clawed frog) ZSCAN21 ARP39869_T100 Q28F32_XENTR Novel zinc finger protein (Silurana tropicalis) 497 76.00% Xenopus tropicalis (Western clawed frog) ZSCAN21 ARP39869_T100 A9ULJ9_XENTR Putative uncharacterized protein LOC548841 (Silurana tropicalis) 497 76.00% Xenopus tropicalis (Western clawed frog) ZSCAN21 ARP39869_T100 Q28BV0_XENTR Novel zinc finger protein (Silurana tropicalis) 555 83.00% Zinc finger protein Xfin (Xenopus fingers ZSCAN21 ARP39869_T100 XFIN_XENLA protein) (Xfin) Xenopus laevis (African clawed frog) 1350 75.00%

ZSCAN21 ARP39869_T100 ZO20_XENLA Oocyte zinc finger protein XlCOF20 (Fragment) Xenopus laevis (African clawed frog) 247 78.00% Xenopus tropicalis (Western clawed frog) ZSCAN21 ARP39869_T100 Q28D25_XENTR Novel zinc finger protein (Silurana tropicalis) 291 75.00% Xenopus tropicalis (Western clawed frog) ZSCAN21 ARP39869_T100 B0S4Q2_XENTR Putative uncharacterized protein (Silurana tropicalis) 215 75.00% Xenopus tropicalis (Western clawed frog) KCTD4 ARP35572_P050 B2GU73_XENTR LOC100158517 protein (Silurana tropicalis) 257 100.00% Wingless‐type MMTV integration site family, Wnt3 ARP58818_P050 B7ZR66_XENLA member 3 Xenopus laevis (African clawed frog) 352 85.00% Wnt3 ARP58818_P050 WNT3A_XENLA Protein Wnt‐3a (XWnt‐3a) Xenopus laevis (African clawed frog) 352 85.00% Xenopus tropicalis (Western clawed frog) Wnt3 ARP58818_P050 A4ZGP0_XENTR Wnt3 (Silurana tropicalis) 354 78.00% Xenopus tropicalis (Western clawed frog) DKFZp727A051 ARP32762_T100 B0JZD8_XENTR Pias3 protein (Silurana tropicalis) 635 92.00% DKFZp727A051 ARP32762_T100 Q6GMA8_XENLA MGC81944 protein Xenopus laevis (African clawed frog) 633 85.00% Tnni2 ARP41391_P050 Q8QGC6_XENLA Fast troponin I (MGC53248 protein) Xenopus laevis (African clawed frog) 182 76.00% Xenopus tropicalis (Western clawed frog) Tnni2 ARP41391_P050 Q5XGD4_XENTR Troponin I type 2 (Skeletal, fast) (Silurana tropicalis) 182 76.00% Xenopus tropicalis (Western clawed frog) Tnni2 ARP41391_P050 A4IH12_XENTR LOC100125108 protein (Silurana tropicalis) 187 78.00% Tnni2 ARP41391_P050 A2VDA1_XENLA LOC100037198 protein Xenopus laevis (African clawed frog) 187 78.00% Xenopus tropicalis (Western clawed frog) Tnni2 ARP41391_P050 Q5M788_XENTR Troponin (Troponin I type 3 (Cardiac)) (Silurana tropicalis) 245 83.00% Tnni2 ARP41391_P050 B7ZS52_XENLA Cardiac troponin I Xenopus laevis (African clawed frog) 244 83.00% Tnni2 ARP41391_P050 TNNI3_XENLA Troponin I, cardiac muscle (Troponin IC) Xenopus laevis (African clawed frog) 244 83.00% GPD1L ARP42227_P050 Q6GN03_XENLA MGC83663 protein Xenopus laevis (African clawed frog) 349 92.00% GPD1L ARP42227_P050 Q7ZYM3_XENLA Gpd1 protein Xenopus laevis (African clawed frog) 348 92.00% Glycerol‐3‐phosphate dehydrogenase 1 (Soluble) (Glycerol‐3‐phosphate Xenopus tropicalis (Western clawed frog) GPD1L ARP42227_P050 Q6DFQ1_XENTR dehydrogenase 1‐like) (Silurana tropicalis) 348 92.00% Glycerol‐3‐phosphate dehydrogenase 1‐like Xenopus tropicalis (Western clawed frog) GPD1L ARP42227_P050 GPD1L_XENTR protein (EC 1.1.1.8) (Silurana tropicalis) 352 83.00% Glycerol‐3‐phosphate dehydrogenase 1‐like GPD1L ARP42227_P050 GPD1L_XENLA protein (EC 1.1.1.8) Xenopus laevis (African clawed frog) 352 83.00% Xenopus tropicalis (Western clawed frog) ARP52803_P050 Q0VFI1_XENTR DIRAS family, GTP‐binding RAS‐like 1 (Silurana tropicalis) 198 92.00% ARP35246_T100 Q6GM25_XENLA MGC84022 protein Xenopus laevis (African clawed frog) 231 100.00% ARP35246_T100 Q640X4_XENLA Kcnip2 protein Xenopus laevis (African clawed frog) 231 100.00% ORF Names:v1g193817OrganismNematostel la vectensis (Starlet sea anemone) ARP40707_P050 Q66KU9_XENLA MGC85411 protein Xenopus laevis (African clawed frog) 80 100.00%

ORF Names:v1g193817OrganismNematostel Xenopus tropicalis (Western clawed frog) la vectensis (Starlet sea anemone) ARP40707_P050 Q0VFB8_XENTR MGC147213 protein (Silurana tropicalis) 80 100.00% Xenopus tropicalis (Western clawed frog) foxb1 ARP35849_P050 B0JZ54_XENTR Foxb1 protein (Silurana tropicalis) 322 92.00% Forkhead box protein B1 (FoxB1) foxb1 ARP35849_P050 FOXB1_XENLA (Transcription factor FKH‐5) Xenopus laevis (African clawed frog) 319 85.00% Nucleolar and spindle‐associated protein 1‐C nusap1‐b ARP46245_P050 NSAPC_XENLA (NuSAP C) Xenopus laevis (African clawed frog) 525 85.00% Nucleolar and spindle‐associated protein 1‐A nusap1‐b ARP46245_P050 NSAPA_XENLA (NuSAP A) Xenopus laevis (African clawed frog) 525 85.00% Nucleolar and spindle‐associated protein 1‐B nusap1‐b ARP46245_P050 NSAPB_XENLA (NuSAP B) Xenopus laevis (African clawed frog) 496 78.00% Xenopus tropicalis (Western clawed frog) nusap1‐b ARP46245_P050 B2GTZ9_XENTR Nusap1 protein (Silurana tropicalis) 498 78.00% Nucleolar and spindle‐associated protein 1 Xenopus tropicalis (Western clawed frog) nusap1‐b ARP46245_P050 NUSAP_XENTR (NuSAP) (Silurana tropicalis) 500 78.00% Xenopus tropicalis (Western clawed frog) PCTK3 AVARP03011_P050 Q6DF28_XENTR PCTAIRE protein kinase 3 (Silurana tropicalis) 462 91.00% CHN2 ARP51862_P050 Q6GNI5_XENLA MGC82782 protein Xenopus laevis (African clawed frog) 332 78.00% Methyl‐CpG‐binding protein 2 (Methyl‐CpG‐ MECP2 ARP38539_P050 Q9YGC6_XENLA binding protein MeCP2) Xenopus laevis (African clawed frog) 467 78.00% Xenopus tropicalis (Western clawed frog) MECP2 ARP38539_P050 B4F6Y0_XENTR Putative uncharacterized protein (Silurana tropicalis) 466 78.00% ARP39712_P050 Q7ZX94_XENLA MGC53880 protein Xenopus laevis (African clawed frog) 387 92.00% ARP39712_P050 Q7ZYQ7_XENLA Ssbp2‐prov protein Xenopus laevis (African clawed frog) 359 92.00% ARP39712_P050 Q6NRV5_XENLA Ssbp2‐prov protein Xenopus laevis (African clawed frog) 387 92.00% Xenopus tropicalis (Western clawed frog) ARP39712_P050 B4F6X9_XENTR Putative uncharacterized protein (Silurana tropicalis) 387 92.00% ARP39712_P050 Q801Q3_XENLA Ssbp3‐prov protein Xenopus laevis (African clawed frog) 391 84.00% Xenopus tropicalis (Western clawed frog) ARP39712_P050 Q6P4M2_XENTR Single stranded DNA binding protein 3 (Silurana tropicalis) 392 84.00% Xenopus tropicalis (Western clawed frog) ARP39712_P050 B4F6Z1_XENTR Ssbp3 protein (Silurana tropicalis) 391 84.00% Xenopus tropicalis (Western clawed frog) ARP39712_P050 A0JLY6_XENTR Ssbp3 protein (Silurana tropicalis) 396 84.00% BUB3 ARP58599_P050 Q9YGY3_XENLA Mitotic checkpoint Xenopus laevis (African clawed frog) 330 92.00% BUB3 ARP58599_P050 Q98UH2_XENLA WD repeat protein Bub3 (Xbub3 protein) Xenopus laevis (African clawed frog) 324 92.00% Xenopus tropicalis (Western clawed frog) BUB3 ARP58599_P050 Q68FA8_XENTR Bub3 protein (Silurana tropicalis) 324 92.00% BUB3 budding uninhibited by benzimidazoles Xenopus tropicalis (Western clawed frog) BUB3 ARP58599_P050 Q28I10_XENTR 3 homolog (Yeast) (Silurana tropicalis) 330 92.00% ARP43329_P050 B1H1T6_XENLA LOC100158302 protein Xenopus laevis (African clawed frog) 599 92.00%

ORF Names:GP2143_18186 EMBL EAW33211.1Organismmarine gamma proteobacterium HTCC2143 ARP42480_P050 A6H8K0_XENLA LOC100101335 protein (Fragment) Xenopus laevis (African clawed frog) 371 100.00% LOC100158620 ARP43120_P050 Q6DCC4_XENLA Fbxo3‐prov protein Xenopus laevis (African clawed frog) 449 92.00% LOC100158620 ARP43120_P050 Q52KV8_XENLA MGC115036 protein Xenopus laevis (African clawed frog) 378 85.00% Xenopus tropicalis (Western clawed frog) LOC100158620 ARP43120_P050 B2GUN1_XENTR LOC100158620 protein (Fragment) (Silurana tropicalis) 446 84.00% ORF Names:PVX_111085 EMBL EDL42418.1OrganismPlasmodium vivax (strain Salvador I) ARP52175_P050 Q6GNU4_XENLA MGC80871 protein Xenopus laevis (African clawed frog) 266 100.00% ORF Names:PVX_111085 EMBL EDL42418.1OrganismPlasmodium vivax Xenopus tropicalis (Western clawed frog) (strain Salvador I) ARP52175_P050 Q5BL45_XENTR MGC69373 protein (Silurana tropicalis) 267 100.00% ORF Names:PVX_111085 EMBL EDL42418.1OrganismPlasmodium vivax (strain Salvador I) ARP52175_P050 Q2TAF9_XENLA MGC132157 protein Xenopus laevis (African clawed frog) 245 100.00% ORF Names:PVX_111085 EMBL EDL42418.1OrganismPlasmodium vivax Acidic leucine‐rich nuclear phosphoprotein 32 Xenopus tropicalis (Western clawed frog) (strain Salvador I) ARP52175_P050 AN32B_XENTR family member B (Silurana tropicalis) 242 100.00% ORF Names:PVX_111085 EMBL EDL42418.1OrganismPlasmodium vivax Acidic leucine‐rich nuclear phosphoprotein 32 (strain Salvador I) ARP52175_P050 AN32B_XENLA family member B Xenopus laevis (African clawed frog) 239 100.00% ORF Names:PVX_111085 EMBL EDL42418.1OrganismPlasmodium vivax Acidic nuclear phosphoprotein 32 family, (strain Salvador I) ARP52175_P050 B2L3Y1_XENBO member B alpha (Fragment) Xenopus borealis (Kenyan clawed frog) 51 100.00% ORF Names:PVX_111085 EMBL EDL42418.1OrganismPlasmodium vivax (strain Salvador I) ARP52175_P050 Q505N1_XENLA MGC114736 protein Xenopus laevis (African clawed frog) 263 85.00% ORF Names:PVX_111085 EMBL EDL42418.1OrganismPlasmodium vivax Acidic (Leucine‐rich) nuclear phosphoprotein Xenopus tropicalis (Western clawed frog) (strain Salvador I) ARP52175_P050 Q28BK6_XENTR 32 family, member E (Silurana tropicalis) 264 85.00% ORF Names:PVX_111085 EMBL EDL42418.1OrganismPlasmodium vivax Xenopus tropicalis (Western clawed frog) (strain Salvador I) ARP52175_P050 B1H1Z2_XENTR Putative uncharacterized protein (Silurana tropicalis) 189 85.00% ORF Names:PVX_111085 EMBL EDL42418.1OrganismPlasmodium vivax Acidic leucine‐rich nuclear phosphoprotein 32 (strain Salvador I) ARP52175_P050 AN32E_XENLA family member E Xenopus laevis (African clawed frog) 263 85.00% ORF Names:PVX_111085 EMBL Acidic (Leucine‐rich) nuclear phosphoprotein EDL42418.1OrganismPlasmodium vivax 32 family, member B (Putative Xenopus tropicalis (Western clawed frog) (strain Salvador I) ARP52175_P050 Q28CW9_XENTR uncharacterized protein LOC549500) (Silurana tropicalis) 244 92.00% ORF Names:PVX_111085 EMBL EDL42418.1OrganismPlasmodium vivax Acidic leucine‐rich nuclear phosphoprotein 32 (strain Salvador I) ARP52175_P050 AN32A_XENLA family member A Xenopus laevis (African clawed frog) 244 92.00% NUP116 ARP39251_P050 Q6DCP4_XENLA Nup98 protein (Fragment) Xenopus laevis (African clawed frog) 647 90.00% ICA1 ARP54743_P050 Q8AVX4_XENLA Ica1‐prov protein Xenopus laevis (African clawed frog) 512 100.00% ICA1 ARP54743_P050 Q6NTK0_XENLA MGC83241 protein Xenopus laevis (African clawed frog) 516 100.00% Xenopus tropicalis (Western clawed frog) ICA1 ARP54743_P050 Q28DQ1_XENTR Islet cell autoantigen 1 (Silurana tropicalis) 515 100.00% Xenopus tropicalis (Western clawed frog) ICA1 ARP54743_P050 A4II33_XENTR Ica1 protein (Silurana tropicalis) 530 100.00% ORF Names:PANDA_014682 EMBL EFB29124.1OrganismAiluropoda melanoleuca (Giant panda) ARP41266_P050 FZD4_XENLA Frizzled‐4 (Fz‐4) (Xfz4) Xenopus laevis (African clawed frog) 523 92.00%

LOC100037019 ARP43304_T100 B1H1N5_XENLA Putative uncharacterized protein (Fragment) Xenopus laevis (African clawed frog) 508 78.00% LOC100037019 ARP43304_T100 A1L3I9_XENLA LOC100037019 protein (Fragment) Xenopus laevis (African clawed frog) 496 78.00% Xenopus tropicalis (Western clawed frog) LOC100037019 ARP43304_T100 Q28I34_XENTR Ring finger protein 38 (Silurana tropicalis) 432 78.00% Zfp932 ARP37812_P050 Q7T246_XENLA Negatively regulating zinc finger protein Xenopus laevis (African clawed frog) 613 100.00%

ORF Names:An12g00630 EMBL CAK40992.1OrganismAspergillus niger (strain CBS 513.88 / FGSC A1513) ARP35652_P050 Q7ZXG1_XENLA Smarcd1 protein (Fragment) Xenopus laevis (African clawed frog) 481 92.00%

ORF Names:An12g00630 EMBL SWI/SNF related, matrix associated, actin CAK40992.1OrganismAspergillus niger dependent regulator of chromatin, subfamily Xenopus tropicalis (Western clawed frog) (strain CBS 513.88 / FGSC A1513) ARP35652_P050 Q6GL18_XENTR d, member 1 (Silurana tropicalis) 508 92.00%

ORF Names:An12g00630 EMBL CAK40992.1OrganismAspergillus niger (strain CBS 513.88 / FGSC A1513) ARP35652_P050 Q6DCP7_XENLA Smarcd1 protein (Fragment) Xenopus laevis (African clawed frog) 513 92.00%

ORF Names:An12g00630 EMBL CAK40992.1OrganismAspergillus niger (strain CBS 513.88 / FGSC A1513) ARP35652_P050 Q66J25_XENLA Smarcd1 protein (Fragment) Xenopus laevis (African clawed frog) 504 92.00%

ORF Names:An12g00630 EMBL CAK40992.1OrganismAspergillus niger (strain CBS 513.88 / FGSC A1513) ARP35652_P050 Q505N3_XENLA Smarcd1 protein (Fragment) Xenopus laevis (African clawed frog) 496 92.00% ORF Names:An12g00630 EMBL SWI/SNF related, matrix associated, actin CAK40992.1OrganismAspergillus niger dependent regulator of chromatin, subfamily Xenopus tropicalis (Western clawed frog) (strain CBS 513.88 / FGSC A1513) ARP35652_P050 Q28CT6_XENTR d, member 1 (Silurana tropicalis) 508 92.00%

ORF Names:An12g00630 EMBL CAK40992.1OrganismAspergillus niger (strain CBS 513.88 / FGSC A1513) ARP35652_P050 A1A5J8_XENLA Smarcd1 protein Xenopus laevis (African clawed frog) 507 92.00%

ORF Names:An12g00630 EMBL CAK40992.1OrganismAspergillus niger (strain CBS 513.88 / FGSC A1513) ARP35652_P050 Q66IP7_XENLA MGC86299 protein Xenopus laevis (African clawed frog) 465 76.00%

ORF Names:An12g00630 EMBL CAK40992.1OrganismAspergillus niger (strain CBS 513.88 / FGSC A1513) ARP35652_P050 Q52L33_XENLA MGC115001 protein Xenopus laevis (African clawed frog) 369 76.00%

ORF Names:v1g164975OrganismNematostel la vectensis (Starlet sea anemone) ARP39578_P050 B7ZRR5_XENLA Xebf‐3 protein Xenopus laevis (African clawed frog) 597 85.00%

ORF Names:v1g164975OrganismNematostel Transcription factor COE3 (xCOE3) (Olf‐1/EBF‐ la vectensis (Starlet sea anemone) ARP39578_P050 COE3_XENLA like 2) (OE‐2) (xEBF‐3) (xOE‐2) Xenopus laevis (African clawed frog) 598 85.00% far1 ARP47392_P050 Q6P411_XENLA MGC68717 protein Xenopus laevis (African clawed frog) 518 85.00%

Fatty acyl‐CoA reductase 1 (EC 1.2.1.n2) (Male far1 ARP47392_P050 FACR1_XENLA sterility domain‐containing protein 2) Xenopus laevis (African clawed frog) 515 85.00% ELF1 ARP31085_P050 Q7ZXI9_XENLA Elf‐1‐prov protein Xenopus laevis (African clawed frog) 637 100.00% ELF1 ARP31085_P050 Q5XH59_XENLA LOC495059 protein Xenopus laevis (African clawed frog) 636 100.00% E74‐like factor 1 (Ets domain transcription Xenopus tropicalis (Western clawed frog) ELF1 ARP31085_P050 Q0IHW0_XENTR factor) (Silurana tropicalis) 632 100.00% ORF Names:CpipJ_CPIJ017677 EMBL EDS25912.1OrganismCulex quinquefasciatus (Southern house Xenopus tropicalis (Western clawed frog) mosquito) (Culex pungens) ARP54671_P050 Q6P4X0_XENTR Putative uncharacterized protein MGC76184 (Silurana tropicalis) 538 92.00% Micophthalmia‐associated transcription factor MITF ARP37978_P050 Q76DN5_XENLA type M Xenopus laevis (African clawed frog) 392 92.00% Micophthalmia‐associated transcription factor MITF ARP37978_P050 Q76DN4_XENLA type A Xenopus laevis (African clawed frog) 483 92.00% Microphthalmia‐associated transcription MITF ARP37978_P050 Q76DN3_XENLA factor type M Xenopus laevis (African clawed frog) 392 92.00% Micophthalmia‐associated transcription factor MITF ARP37978_P050 Q76DN2_XENLA type A Xenopus laevis (African clawed frog) 483 92.00%

MITF ARP37978_P050 B2GTX5_XENLA Putative uncharacterized protein (Fragment) Xenopus laevis (African clawed frog) 478 92.00% Xenopus tropicalis (Western clawed frog) MITF ARP37978_P050 A4IID0_XENTR Mitf protein (Silurana tropicalis) 483 84.00% Xenopus tropicalis (Western clawed frog) ARP47522_P050 B5DE12_XENTR Putative uncharacterized protein (Silurana tropicalis) 645 85.00%

Forkhead box protein K2 (FoxK2) (Interleukin foxk2 ARP47522_P050 FOXK2_XENLA enhancer‐binding factor 1) (ILF1) (xFoxK1) Xenopus laevis (African clawed frog) 642 85.00%

ORF Names:v1g208351OrganismNematostel la vectensis (Starlet sea anemone) ARP48895_T100 Q6DDQ9_XENLA MGC82494 protein Xenopus laevis (African clawed frog) 413 100.00%

ORF Names:v1g208351OrganismNematostel Xenopus tropicalis (Western clawed frog) la vectensis (Starlet sea anemone) ARP48895_T100 B2GUS7_XENTR LOC100158650 protein (Silurana tropicalis) 531 100.00% Xenopus tropicalis (Western clawed frog) prkcbp1 ARP34729_P050 Q6DFS9_XENTR Protein kinase C binding protein 1 (Silurana tropicalis) 1145 92.00% prkcbp1 ARP34729_P050 Q4V7I2_XENLA LOC733267 protein (Fragment) Xenopus laevis (African clawed frog) 377 92.00% Zinc finger and MYND domain containing prkcbp1 ARP34729_P050 D5LMF5_XENLA protein 8 Xenopus laevis (African clawed frog) 1165 92.00% Xenopus tropicalis (Western clawed frog) prkcbp1 ARP34729_P050 A0JM61_XENTR Prkcbp1 protein (Silurana tropicalis) 1163 92.00% SLC7A10 ARP43930_T100 Q7ZWV7_XENLA MGC53111 protein Xenopus laevis (African clawed frog) 529 100.00% SLC7A10 ARP43930_T100 Q7ZTM3_XENLA Slc7a8‐prov protein Xenopus laevis (African clawed frog) 527 100.00% Solute carrier family 7 (Cationic amino acid Xenopus tropicalis (Western clawed frog) SLC7A10 ARP43930_T100 Q6P891_XENTR transporter, y+ system), member 8 (Silurana tropicalis) 529 100.00% ARP43058_P050 Q32NH0_XENLA LOC733415 protein (Fragment) Xenopus laevis (African clawed frog) 301 82.00% STIP1 homology and U‐Box containing protein Xenopus tropicalis (Western clawed frog) ARP43058_P050 Q0V9Q4_XENTR 1 (Silurana tropicalis) 310 77.00%

Phosphatidylinositol 4‐kinase beta (PI4K‐beta) Xenopus tropicalis (Western clawed frog) pi4kb ARP56393_P050 PI4KB_XENTR (PI4Kbeta) (PtdIns 4‐kinase beta) (EC 2.7.1.67) (Silurana tropicalis) 806 100.00%

Phosphatidylinositol 4‐kinase beta (PI4K‐beta) pi4kb ARP56393_P050 PI4KB_XENLA (PI4Kbeta) (PtdIns 4‐kinase beta) (EC 2.7.1.67) Xenopus laevis (African clawed frog) 804 100.00% NFIC P100976_P050 Q91800_XENLA Nuclear factor I‐C1 Xenopus laevis (African clawed frog) 501 86.00% NFIC P100976_P050 Q9PS98_XENLA Nuclear factor I subtype C isoform 1 Xenopus laevis (African clawed frog) 499 80.00% NFIC P100976_P050 B7ZRC3_XENLA Putative uncharacterized protein Xenopus laevis (African clawed frog) 499 80.00% Xenopus tropicalis (Western clawed frog) LOC100135108 ARP53184_P050 A9JRM5_XENTR LOC100135108 protein (Fragment) (Silurana tropicalis) 413 92.00% ARP56082_P050 C0IW62_XENLA Norrin Xenopus laevis (African clawed frog) 132 85.00% ORF Names:PANDA_015389 EMBL EFB16051.1OrganismAiluropoda melanoleuca (Giant panda) ARP38239_P050 Q6PA13_XENLA MGC68827 protein Xenopus laevis (African clawed frog) 767 100.00% Exosc10 ARP40225_T100 Q6NRJ3_XENLA MGC83774 protein Xenopus laevis (African clawed frog) 883 78.00% Xenopus tropicalis (Western clawed frog) Exosc10 ARP40225_T100 Q6NVP3_XENTR Exosome component 10 (Silurana tropicalis) 883 78.00% LOC100036831 ARP52092_P050 Q7T0U5_XENLA Arpc3‐prov protein Xenopus laevis (African clawed frog) 178 100.00% Actin related protein 2/3 complex, subunit 3, Xenopus tropicalis (Western clawed frog) LOC100036831 ARP52092_P050 A9UL86_XENTR 21kDa (Arpc3 protein) (Silurana tropicalis) 178 100.00%

LOC100036831 ARP52092_P050 A1DPK7_XENLA Actin‐related protein 2/3 complex subunit 3 Xenopus laevis (African clawed frog) 178 100.00% Potassium voltage‐gated channel KQT‐like Xenopus tropicalis (Western clawed frog) KCNQ5 ARP35457_P050 Q0P4Q9_XENTR protein 4 (Silurana tropicalis) 606 84.00%

ORF Names:AGAP000829OrganismAnophel Xenopus tropicalis (Western clawed frog) es gambiae (African malaria mosquito) ARP38646_P050 A8WGH7_XENTR Solh protein (Silurana tropicalis) 985 100.00% Pgm1 ARP56384_P050 Q7ZYA3_XENLA Pgm2‐prov protein Xenopus laevis (African clawed frog) 562 92.00% Pgm1 ARP56384_P050 Q6NTQ3_XENLA LOC414455 protein (Fragment) Xenopus laevis (African clawed frog) 586 92.00% Xenopus tropicalis (Western clawed frog) Pgm1 ARP56384_P050 Q6NVJ0_XENTR Phosphoglucomutase 1 (Silurana tropicalis) 562 85.00% V‐type proton ATPase subunit d 2 (V‐ATPase subunit d 2) (Vacuolar proton pump subunit d Xenopus tropicalis (Western clawed frog) atp6v0d1 ARP55488_P050 VA0D2_XENTR 2) (Silurana tropicalis) 350 92.00% atp6v0d1 ARP55488_P050 Q7ZYR4_XENLA Atp6v0d1 protein Xenopus laevis (African clawed frog) 351 76.00% ATPase, H+ transporting, lysosomal 38kDa, V0 Xenopus tropicalis (Western clawed frog) atp6v0d1 ARP55488_P050 A0JLY8_XENTR subunit d1 (Silurana tropicalis) 351 76.00% Xenopus tropicalis (Western clawed frog) gpr161 ARP42712_T100 GP161_XENTR G‐protein coupled receptor 161 (Silurana tropicalis) 518 76.00% LOC100135270 ARP36350_P050 Q6GNR2_XENLA MGC80941 protein Xenopus laevis (African clawed frog) 1098 85.00% Xenopus tropicalis (Western clawed frog) LOC100135270 ARP36350_P050 A9UM85_XENTR LOC100135270 protein (Fragment) (Silurana tropicalis) 587 85.00% Xenopus tropicalis (Western clawed frog) PARP6 ARP33766_T100 A4IGR1_XENTR LOC100038271 protein (Silurana tropicalis) 621 85.00% Xenopus tropicalis (Western clawed frog) lman2 ARP46788_P050 Q0VFQ7_XENTR Putative uncharacterized protein MGC145312 (Silurana tropicalis) 333 92.00% Xenopus tropicalis (Western clawed frog) PSMB9 ARP46081_P050 Q6XXY2_XENTR Proteasome beta subunit (Silurana tropicalis) 215 100.00% Xenopus tropicalis (Western clawed frog) PSMB9 ARP46081_P050 Q6XXY1_XENTR Proteasome beta subunit (Silurana tropicalis) 215 100.00% LMP2 (Proteasome (Prosome, macropain) subunit, beta type, 9 (Large multifunctional PSMB9 ARP46081_P050 O12999_XENLA protease 2)) Xenopus laevis (African clawed frog) 215 100.00% Xenopus tropicalis (Western clawed frog) ARP44989_P050 Q05AQ9_XENTR Putative uncharacterized protein MGC147524 (Silurana tropicalis) 625 85.00% ARP44989_P050 Q7T0P3_XENLA MGC69113 protein Xenopus laevis (African clawed frog) 606 78.00% LIN9 ARP50820_P050 B1H1U1_XENLA LOC100158306 protein Xenopus laevis (African clawed frog) 562 90.00% LOC446288 ARP35326_T100 Q68EY1_XENLA LOC446288 protein (Fragment) Xenopus laevis (African clawed frog) 546 92.00%

DNA ligase 1 (EC 6.5.1.1) (DNA ligase I) LIG1 ARP54307_P050 DNLI1_XENLA (Polydeoxyribonucleotide synthase [ATP] 1) Xenopus laevis (African clawed frog) 1070 85.00% ARP56328_P050 Q7ZTJ4_XENLA Vha55 protein Xenopus laevis (African clawed frog) 511 85.00%

ATPase, H+ transporting, lysosomal (Vacuolar Xenopus tropicalis (Western clawed frog) ARP56328_P050 Q0VGW2_XENTR proton pump), beta 56/58 kDa, isoform 2 (Silurana tropicalis) 505 85.00% Xenopus tropicalis (Western clawed frog) ARP56328_P050 B0BMI3_XENTR Atp6v1b1 protein (Silurana tropicalis) 495 76.00% Protein argonaute‐4 (Argonaute4) (Eukaryotic translation initiation factor 2C 4) (eIF‐2C 4) EIF2C4 ARP58795_P050 AGO4_XENLA (eIF2C 4) Xenopus laevis (African clawed frog) 884 85.00% Xenopus tropicalis (Western clawed frog) ARP58529_P050 Q6DJC5_XENTR 2, mitochondrial (Silurana tropicalis) 224 85.00% ARP58529_P050 Q6UTE6_XENLA Manganese superoxide dismutase Xenopus laevis (African clawed frog) 224 83.00% ARP58529_P050 Q6GP18_XENLA MGC80739 protein Xenopus laevis (African clawed frog) 224 83.00% Kruppel‐like transcription factor neptune cbr‐klf‐3 ARP39242_P050 Q90XS5_XENLA (LOC398243 protein) Xenopus laevis (African clawed frog) 413 100.00% cbr‐klf‐3 ARP39242_P050 Q8QGW6_XENLA Blood island enriched kruppel like factor Xenopus laevis (African clawed frog) 413 100.00% Klf2 protein (Lung enriched kruppel like cbr‐klf‐3 ARP39242_P050 Q8QGW5_XENLA factor) Xenopus laevis (African clawed frog) 373 100.00% cbr‐klf‐3 ARP39242_P050 Q7SZU5_XENLA Biklf‐A protein Xenopus laevis (African clawed frog) 413 100.00% cbr‐klf‐3 ARP39242_P050 Q2TAV3_XENLA Biklf‐A protein Xenopus laevis (African clawed frog) 392 100.00% Kruppel‐like factor 2 (Lung) (Novel kruppel‐ Xenopus tropicalis (Western clawed frog) cbr‐klf‐3 ARP39242_P050 Q28D19_XENTR like factor family protein) (Silurana tropicalis) 373 100.00% Xenopus tropicalis (Western clawed frog) cbr‐klf‐3 ARP39242_P050 Q28BQ7_XENTR Novel kruppel‐like factor family protein (Silurana tropicalis) 413 100.00% cbr‐klf‐3 ARP39242_P050 Q7ZXK7_XENLA Copeb‐prov protein Xenopus laevis (African clawed frog) 283 100.00% cbr‐klf‐3 ARP39242_P050 Q7SY91_XENLA Klf7‐prov protein Xenopus laevis (African clawed frog) 293 100.00% Xenopus tropicalis (Western clawed frog) cbr‐klf‐3 ARP39242_P050 Q6DIM6_XENTR Zinc finger protein 534 (Silurana tropicalis) 368 100.00% Xenopus tropicalis (Western clawed frog) cbr‐klf‐3 ARP39242_P050 Q68FA0_XENTR Copeb protein (Silurana tropicalis) 283 100.00% cbr‐klf‐3 ARP39242_P050 Q66KQ9_XENLA LOC446965 protein (Fragment) Xenopus laevis (African clawed frog) 278 100.00% Xenopus tropicalis (Western clawed frog) cbr‐klf‐3 ARP39242_P050 Q28D29_XENTR Klf4 protein (Kruppel‐like factor 4 (Gut)) (Silurana tropicalis) 407 100.00% Xenopus tropicalis (Western clawed frog) cbr‐klf‐3 ARP39242_P050 Q0IHT4_XENTR Kruppel‐like factor 7 (Ubiquitous) (Silurana tropicalis) 296 100.00% Xenopus tropicalis (Western clawed frog) cbr‐klf‐3 ARP39242_P050 A0JLZ3_XENTR Klf4 protein (Fragment) (Silurana tropicalis) 418 100.00% cbr‐klf‐3 ARP39242_P050 Q7T3J7_XENLA AP‐2 repressor Xenopus laevis (African clawed frog) 357 80.00% cbr‐klf‐3 ARP39242_P050 B7ZR90_XENLA AP‐2 repressor Xenopus laevis (African clawed frog) 357 80.00% Xenopus tropicalis (Western clawed frog) cbr‐klf‐3 ARP39242_P050 B1H3D6_XENTR Klf8 protein (Silurana tropicalis) 337 80.00% Xenopus tropicalis (Western clawed frog) NDRG2 ARP47976_P050 NDRG2_XENTR Protein NDRG2 (Silurana tropicalis) 360 100.00% NDRG2 ARP47976_P050 NDRG2_XENLA Protein NDRG2 Xenopus laevis (African clawed frog) 360 100.00% Gtf2h2 P100893_P050 Q6GR42_XENLA MGC81060 protein Xenopus laevis (African clawed frog) 395 100.00%

General transcription factor IIH polypeptide 4, 52kDa (General transcription factor IIH, Xenopus tropicalis (Western clawed frog) Gtf2h2 P100893_P050 Q5XGG8_XENTR polypeptide 2, 44kDa) (Silurana tropicalis) 393 100.00% ARP41656_P050 Q6GN55_XENLA MGC83017 protein Xenopus laevis (African clawed frog) 330 84.00% ARP41656_P050 Q6GLK5_XENLA MGC84775 protein Xenopus laevis (African clawed frog) 330 84.00% CDC23 ARP43039_T100 Q8AVF0_XENLA Cdc23‐prov protein Xenopus laevis (African clawed frog) 522 100.00% CDC23 ARP43039_T100 Q7T0N9_XENLA MGC69122 protein Xenopus laevis (African clawed frog) 580 100.00% Xenopus tropicalis (Western clawed frog) CDC23 ARP43039_T100 Q28D09_XENTR CDC23 (Cell division cycle 23, yeast, homolog) (Silurana tropicalis) 581 100.00% Rhombotin‐2 (LIM domain only protein 2) Xenopus tropicalis (Western clawed frog) Lmo2 P100952_P050 RBTN2_XENTR (LMO‐2) (Silurana tropicalis) 158 85.00% Rhombotin‐2 (LIM domain only protein 2) Lmo2 P100952_P050 RBTN2_XENLA (LMO‐2) (Lmo2‐A) (xLMO‐2) Xenopus laevis (African clawed frog) 158 85.00% LOC615069 ARP51799_P050 Q7T0Y6_XENLA Mgc12909‐prov protein Xenopus laevis (African clawed frog) 402 100.00% LOC615069 ARP51799_P050 Q6GNN0_XENLA MGC80990 protein Xenopus laevis (African clawed frog) 402 100.00% Xenopus tropicalis (Western clawed frog) LOC615069 ARP51799_P050 B7ZUQ7_XENTR Putative uncharacterized protein LOC548782 (Silurana tropicalis) 261 100.00%

Strbp ARP40914_P050 STRBP_XENLA Spermatid perinuclear RNA‐binding protein Xenopus laevis (African clawed frog) 686 85.00% Putative uncharacterized protein Xenopus tropicalis (Western clawed frog) Strbp ARP40914_P050 B7ZU24_XENTR LOC100135229 (Silurana tropicalis) 698 78.00% Xenopus tropicalis (Western clawed frog) Strbp ARP40914_P050 B1H108_XENTR LOC100135229 protein (Silurana tropicalis) 675 78.00% Xenopus tropicalis (Western clawed frog) Strbp ARP40914_P050 A9ULQ1_XENTR LOC100135229 protein (Silurana tropicalis) 698 78.00% Dolichyl‐diphosphooligosaccharide‐‐protein glycosyltransferase 48 kDa subunit (DDOST 48 kDa subunit) (Oligosaccharyl transferase 48 Xenopus tropicalis (Western clawed frog) DDOST ARP46585_T100 OST48_XENTR kDa subunit) (EC 2.4.1.119) (Silurana tropicalis) 437 100.00%

Dolichyl‐diphosphooligosaccharide‐‐protein glycosyltransferase 48 kDa subunit (DDOST 48 kDa subunit) (Oligosaccharyl transferase 48 DDOST ARP46585_T100 OST48_XENLA kDa subunit) (EC 2.4.1.119) Xenopus laevis (African clawed frog) 438 100.00% ARP31402_P050 Q3I525_XENLA Transcription factor Mxi1 Xenopus laevis (African clawed frog) 239 85.00% mxi1 ARP31402_P050 Q1L2N4_XENLA Mxi1 Xenopus laevis (African clawed frog) 238 85.00% Xenopus tropicalis (Western clawed frog) mxi1 ARP31402_P050 Q66II4_XENTR Max interactor 1 (Silurana tropicalis) 240 85.00% Xenopus tropicalis (Western clawed frog) mxi1 ARP31402_P050 Q28CB7_XENTR MAX interactor 1 (Silurana tropicalis) 262 85.00% mxi1 ARP31402_P050 B7ZPQ0_XENLA Mxd1 protein Xenopus laevis (African clawed frog) 221 78.00% Max dimerization protein 1 (Max dimerizer 1) Xenopus tropicalis (Western clawed frog) mxi1 ARP31402_P050 MAD1_XENTR (Protein MAD) (Silurana tropicalis) 221 78.00% Max dimerization protein 1 (Max dimerizer 1) mxi1 ARP31402_P050 MAD1_XENLA (Protein MAD) Xenopus laevis (African clawed frog) 221 78.00% Transporter associated with antigen TAP1 ARP43628_P050 Q6XXZ1_XENLA processing 1 Xenopus laevis (African clawed frog) 721 84.00% Transporter associated with antigen TAP1 ARP43628_P050 Q6XXZ0_XENLA processing 1 Xenopus laevis (African clawed frog) 726 76.00% Pdk3 protein (Pyruvate dehydrogenase kinase, Xenopus tropicalis (Western clawed frog) PDK3 ARP46126_P050 A9ULF7_XENTR isozyme 3) (Silurana tropicalis) 405 90.00% MAX ARP38145_T100 Q6NRN6_XENLA XMax2 protein Xenopus laevis (African clawed frog) 136 92.00% Xenopus tropicalis (Western clawed frog) MAX ARP38145_T100 Q66IK5_XENTR Max protein (Silurana tropicalis) 127 92.00% Xenopus tropicalis (Western clawed frog) MAX ARP38145_T100 Q28BK0_XENTR MYC associated factor X (Silurana tropicalis) 136 92.00% MAX ARP38145_T100 B7ZPF6_XENLA Myc binding protein Xmax4 Xenopus laevis (African clawed frog) 163 92.00% MAX ARP38145_T100 MAX_XENLA Isoform XMAX3 Xenopus laevis (African clawed frog) 154 92.00% MAX ARP38145_T100 MAX_XENLA Isoform XMAX2 (Isoform XMAX1) Xenopus laevis (African clawed frog) 136 92.00% MAX ARP38145_T100 MAX_XENLA Isoform XMAX1 Xenopus laevis (African clawed frog) 127 92.00%

MAX ARP38145_T100 MAX_XENLA Protein max (xMAX) (Myc‐associated factor X) Xenopus laevis (African clawed frog) 163 92.00% LCP1 lymphocyte cytosolic protein 1 Xenopus tropicalis (Western clawed frog) pls1 ARP54687_P050 Q5FW28_XENTR (MGC107867 protein) (Silurana tropicalis) 627 92.00% pls1 ARP54687_P050 Q7T0S8_XENLA Lcp1‐prov protein Xenopus laevis (African clawed frog) 616 85.00% Xenopus tropicalis (Western clawed frog) pls1 ARP54687_P050 B3DLB0_XENTR LOC100170476 protein (Silurana tropicalis) 624 84.00% cpt1b ARP44796_P050 Q5U257_XENLA LOC495682 protein Xenopus laevis (African clawed frog) 771 92.00% Xenopus tropicalis (Western clawed frog) cpt1b ARP44796_P050 A0JMA3_XENTR Putative uncharacterized protein MGC147544 (Silurana tropicalis) 771 92.00% cpt1b ARP44796_P050 Q7ZWK5_XENLA MGC53498 protein Xenopus laevis (African clawed frog) 768 92.00% Xenopus tropicalis (Western clawed frog) cpt1b ARP44796_P050 A9JRK5_XENTR LOC100135089 protein (Silurana tropicalis) 767 92.00% Xenopus tropicalis (Western clawed frog) jph2 ARP49534_P050 Q07G11_XENTR Junctophilin 1 (Fragment) (Silurana tropicalis) 348 83.00% Xenopus tropicalis (Western clawed frog) jph2 ARP49534_P050 B1H0X6_XENTR LOC100145273 protein (Silurana tropicalis) 560 83.00%

ARP50524_P050 Q90ZT6_XENLA LOC398313 protein (Sprouty 2) (Sprouty2) Xenopus laevis (African clawed frog) 314 78.00% Xenopus tropicalis (Western clawed frog) ARP42287_T100 Q66JE7_XENTR Follistatin (Silurana tropicalis) 320 92.00% ARP42287_T100 FST_XENLA Isoform Short Xenopus laevis (African clawed frog) 319 84.00% Follistatin (FS) (Activin‐binding protein) (XFS‐ ARP42287_T100 FST_XENLA 319) Xenopus laevis (African clawed frog) 341 84.00% Xenopus tropicalis (Western clawed frog) ARP42287_T100 A9UM90_XENTR LOC100135275 protein (Silurana tropicalis) 322 100.00% ZSCAN4 ARP51696_P050 Q4KLQ1_XENLA MGC115682 protein Xenopus laevis (African clawed frog) 585 85.00% ZSCAN4 ARP51696_P050 Q5U4M3_XENLA LOC495467 protein (Fragment) Xenopus laevis (African clawed frog) 581 91.00% Xenopus tropicalis (Western clawed frog) ZSCAN4 ARP51696_P050 B4F6R5_XENTR Putative uncharacterized protein (Silurana tropicalis) 382 91.00% Xenopus tropicalis (Western clawed frog) ZSCAN4 ARP51696_P050 B0JZR8_XENTR Putative uncharacterized protein (Silurana tropicalis) 383 91.00% Xenopus tropicalis (Western clawed frog) ZSCAN4 ARP51696_P050 A9UMD9_XENTR LOC100135323 protein (Silurana tropicalis) 382 91.00% Xenopus tropicalis (Western clawed frog) ZSCAN4 ARP51696_P050 Q28CZ4_XENTR Novel protein (Silurana tropicalis) 400 91.00% ZSCAN4 ARP51696_P050 Q09047_XENLA Zinc finger protein (Fragment) Xenopus laevis (African clawed frog) 354 84.00% Xenopus tropicalis (Western clawed frog) ZSCAN4 ARP51696_P050 Q28IG2_XENTR Novel protein (Fragment) (Silurana tropicalis) 112 84.00% Xenopus tropicalis (Western clawed frog) ZSCAN4 ARP51696_P050 Q28E76_XENTR Novel protein (Fragment) (Silurana tropicalis) 544 84.00% Xenopus tropicalis (Western clawed frog) ZSCAN4 ARP51696_P050 Q28CS9_XENTR Novel zinc finger protein (Silurana tropicalis) 583 91.00% Xenopus tropicalis (Western clawed frog) ZSCAN4 ARP51696_P050 B1H159_XENTR Putative uncharacterized protein (Silurana tropicalis) 587 84.00% Gastrula zinc finger protein XlCGF8.2DB ZSCAN4 ARP51696_P050 ZG8_XENLA (Fragment) Xenopus laevis (African clawed frog) 196 84.00% ZSCAN4 ARP51696_P050 Q58E01_XENLA LOC733184 protein (Fragment) Xenopus laevis (African clawed frog) 224 84.00% Xenopus tropicalis (Western clawed frog) ZSCAN4 ARP51696_P050 B3DLU8_XENTR Putative uncharacterized protein (Silurana tropicalis) 1036 84.00% ORF Names:BRAFLDRAFT_121188 EMBL EEN57749.1OrganismBranchiostoma floridae (Florida lancelet) (Amphioxus) ARP53139_P050 Q6DCH0_XENLA MGC82926 protein Xenopus laevis (African clawed frog) 443 78.00% Xenopus tropicalis (Western clawed frog) Zfp661 ARP39424_T100 Q28GY2_XENTR Novel zinc finger protein (Silurana tropicalis) 421 84.00% Xenopus tropicalis (Western clawed frog) Zfp661 ARP39424_T100 B2RZE9_XENTR Putative uncharacterized protein LOC549148 (Silurana tropicalis) 410 84.00% ORF Names:CC1G_02652 EMBL EAU81636.2OrganismCoprinopsis cinerea (strain Okayama‐7 / 130 / FGSC 9003) (Inky cap fungus) Xenopus tropicalis (Western clawed frog) (Hormographiella aspergillata) ARP35594_P050 B2GU78_XENTR LOC100158521 protein (Silurana tropicalis) 583 90.00% ORF Names:CC1G_02652 EMBL EAU81636.2OrganismCoprinopsis cinerea (strain Okayama‐7 / 130 / FGSC 9003) (Inky cap fungus) (Hormographiella aspergillata) ARP35594_P050 A8WH49_XENLA LOC100127255 protein (Fragment) Xenopus laevis (African clawed frog) 498 90.00% P100879_P050 Q66KI2_XENLA MGC81762 protein Xenopus laevis (African clawed frog) 412 92.00% P100879_P050 Q63ZR9_XENLA LOC494744 protein Xenopus laevis (African clawed frog) 409 92.00% Hypothetical LOC496643 (LOC496643 protein) Xenopus tropicalis (Western clawed frog) P100879_P050 Q5M8Z8_XENTR (Transcription factor Dp‐1) (Silurana tropicalis) 411 92.00% AVARP09052_P050 Q66KI2_XENLA MGC81762 protein Xenopus laevis (African clawed frog) 412 92.00% AVARP09052_P050 Q63ZR9_XENLA LOC494744 protein Xenopus laevis (African clawed frog) 409 92.00% Hypothetical LOC496643 (LOC496643 protein) Xenopus tropicalis (Western clawed frog) AVARP09052_P050 Q5M8Z8_XENTR (Transcription factor Dp‐1) (Silurana tropicalis) 411 92.00% eya1 ARP32434_P050 Q98SL7_XENLA Eyes absent‐1 alpha Xenopus laevis (African clawed frog) 587 92.00% eya1 ARP32434_P050 Q98SL6_XENLA Eyes absent‐1 beta Xenopus laevis (African clawed frog) 592 92.00% Xenopus tropicalis (Western clawed frog) eya1 ARP32434_P050 A0JLZ4_XENTR Eya1 protein (Fragment) (Silurana tropicalis) 577 92.00% pyrD ARP41941_P050 Q6IR81_XENLA LOC432093 protein (Fragment) Xenopus laevis (African clawed frog) 406 84.00% Xenopus tropicalis (Western clawed frog) pyrD ARP41941_P050 Q5BKN2_XENTR MGC107816 protein (Silurana tropicalis) 401 84.00% pyrD ARP41941_P050 Q4QR42_XENLA LOC432093 protein Xenopus laevis (African clawed frog) 404 84.00% GF13520 ARP52336_P050 Q6DCM4_XENLA Spon2‐prov protein Xenopus laevis (African clawed frog) 313 100.00% Xenopus tropicalis (Western clawed frog) GF13520 ARP52336_P050 Q0P4H5_XENTR Putative uncharacterized protein MGC147505 (Silurana tropicalis) 313 100.00% Xenopus tropicalis (Western clawed frog) Sox3 ARP33322_P050 SOX3_XENTR Transcription factor Sox‐3 (Silurana tropicalis) 307 83.00%

Sox3 ARP33322_P050 SOX3A_XENLA Transcription factor Sox‐3‐A (xSox3) (xSox‐B1) Xenopus laevis (African clawed frog) 309 83.00% T ARP33390_P050 Q9W7R8_XENLA Brachyury‐like T‐box transcription factor Xenopus laevis (African clawed frog) 434 92.00% T, brachyury homolog, gene 2 (T2, brachyury Xenopus tropicalis (Western clawed frog) T ARP33390_P050 Q6NX23_XENTR homolog (Mouse)) (Silurana tropicalis) 434 92.00% T ARP33390_P050 B7ZRC9_XENLA Brachyury‐like T‐box transcription factor Xenopus laevis (African clawed frog) 434 92.00% T ARP33390_P050 Q6INQ0_XENLA MGC81453 protein Xenopus laevis (African clawed frog) 432 85.00% T ARP33390_P050 BRAC_XENLA Brachyury protein (xBRA) (Protein T) Xenopus laevis (African clawed frog) 432 85.00% Xenopus tropicalis (Western clawed frog) T ARP33390_P050 Q66IH3_XENTR T, brachyury homolog (Silurana tropicalis) 434 85.00% Xenopus tropicalis (Western clawed frog) T ARP33390_P050 Q28GC9_XENTR T, brachyury homolog (Mouse) (Silurana tropicalis) 433 85.00% ATP5G2 ARP40228_P050 Q8AVE1_XENLA Cg1746‐prov protein Xenopus laevis (African clawed frog) 142 91.00% ATP synthase, H+ transporting, mitochondrial F0 complex, subunit C3 (Subunit 9) Xenopus tropicalis (Western clawed frog) ATP5G2 ARP40228_P050 Q6DET2_XENTR (OTTXETP00000008674) (Silurana tropicalis) 142 83.00%

ATP synthase, H+ transporting, mitochondrial Xenopus tropicalis (Western clawed frog) ATP5G2 ARP40228_P050 B0JZY9_XENTR F0 complex, subunit C3 (Subunit 9) (Silurana tropicalis) 142 83.00% ARP48134_P050 Q98TS5_XENLA Ornithine aminotransferase Xenopus laevis (African clawed frog) 439 85.00% ARP48134_P050 Q7ZX40_XENLA Oat‐prov protein Xenopus laevis (African clawed frog) 439 85.00% ARP48134_P050 Q6DE30_XENLA Oat‐prov protein Xenopus laevis (African clawed frog) 439 85.00% Ornithine aminotransferase (Ornithine Xenopus tropicalis (Western clawed frog) ARP48134_P050 Q28FA4_XENTR aminotransferase (Gyrate atrophy)) (Silurana tropicalis) 439 85.00% Xenopus tropicalis (Western clawed frog) Zbtb43 ARP39047_P050 Q0V9P6_XENTR Zinc finger and BTB domain containing 43 (Silurana tropicalis) 465 92.00% CNN2 ARP52039_P050 Q7ZX19_XENLA Calponin 2 copy A (Cnn2‐prov protein) Xenopus laevis (African clawed frog) 294 92.00% CNN2 ARP52039_P050 O93547_XENLA Calponin H3 Xenopus laevis (African clawed frog) 295 92.00% Xenopus tropicalis (Western clawed frog) CNN2 ARP52039_P050 Q6NVQ5_XENTR Calponin 2 (Silurana tropicalis) 295 84.00% CNN2 ARP52039_P050 Q6GNN7_XENLA MGC80982 protein Xenopus laevis (African clawed frog) 295 84.00% CNN2 ARP52039_P050 A9CDP5_XENLA Calponin 2 copy B Xenopus laevis (African clawed frog) 295 84.00%

Rsrc2 ARP51202_T100 RSRC2_XENLA Arginine/serine‐rich coiled‐coil protein 2 Xenopus laevis (African clawed frog) 350 85.00% Xenopus tropicalis (Western clawed frog) Rsrc2 ARP51202_T100 RSRC2_XENTR Arginine/serine‐rich coiled‐coil protein 2 (Silurana tropicalis) 409 85.00% Rsrc2 ARP51202_T100 Q2TAQ5_XENLA MGC131120 protein Xenopus laevis (African clawed frog) 259 78.00% Xenopus tropicalis (Western clawed frog) olig3 ARP40015_P050 Q640S3_XENTR Oligodendrocyte transcription factor 3 (Silurana tropicalis) 263 78.00% Carbohydrate (N‐acetylgalactosamine 4‐0) Xenopus tropicalis (Western clawed frog) Chst8 ARP49723_P050 Q0D2D0_XENTR sulfotransferase 8 (Silurana tropicalis) 437 84.00% ORF Names:SAMR1017 EMBL CAJ88726.1OrganismStreptomyces ambofaciens ATCC 23877 ARP32452_P050 Q6NTL8_XENLA MGC83198 protein Xenopus laevis (African clawed frog) 322 100.00% Sirtuin (Silent mating type information ORF Names:SAMR1017 EMBL regulation 2 homolog) 4 (Sirtuin (Silent mating CAJ88726.1OrganismStreptomyces type information regulation 2 homolog) 4 (S. Xenopus tropicalis (Western clawed frog) ambofaciens ATCC 23877 ARP32452_P050 Q28CB4_XENTR cerevisiae)) (Silurana tropicalis) 322 100.00% Xenopus tropicalis (Western clawed frog) TBC1D1 ARP55189_P050 Q28GQ9_XENTR Tbc1 domain family member 1 (Fragment) (Silurana tropicalis) 705 78.00% 7‐Mar ARP43307_P050 Q498F5_XENLA LOC733332 protein (Fragment) Xenopus laevis (African clawed frog) 743 100.00% 7‐Mar ARP43307_P050 Q08B24_XENLA LOC733332 protein Xenopus laevis (African clawed frog) 732 100.00% LOC549230 protein (‐related Xenopus tropicalis (Western clawed frog) Tyrp1 ARP44315_P050 Q28HG0_XENTR protein 1) (Silurana tropicalis) 534 85.00% Tyrp1 ARP44315_P050 Q7ZYE8_XENLA Tyrp1‐prov protein Xenopus laevis (African clawed frog) 534 78.00% DSS‐AHC critical region on the , Dax‐1 ARP31632_P050 A4PCW1_XENLA gene 1 (Fragment) Xenopus laevis (African clawed frog) 274 92.00% Xenopus tropicalis (Western clawed frog) Dax‐1 ARP31632_P050 Q501K8_XENTR Nr0b2 protein (Fragment) (Silurana tropicalis) 285 85.00% ORF Names:FBBAL38_00420 EMBL EAZ95837.1OrganismFlavobacteria Xenopus tropicalis (Western clawed frog) bacterium BAL38 ARP48307_P050 COF2_XENTR Cofilin‐2 (Silurana tropicalis) 167 100.00% ORF Names:FBBAL38_00420 EMBL EAZ95837.1OrganismFlavobacteria bacterium BAL38 ARP48307_P050 COF2_XENLA Cofilin‐2 Xenopus laevis (African clawed frog) 167 100.00% Xenopus tropicalis (Western clawed frog) Homer1 ARP40182_P050 A9JTQ6_XENTR Homer1 protein (Silurana tropicalis) 355 100.00% Homer1 ARP40182_P050 Q5I2P4_XENLA Homer 1b‐1 Xenopus laevis (African clawed frog) 355 92.00% Homer1 ARP40182_P050 B7ZRW1_XENLA Homer 1b‐1 Xenopus laevis (African clawed frog) 355 92.00% PCDHA3 ARP45338_P050 Q801S0_XENLA Papc protein Xenopus laevis (African clawed frog) 979 85.00% PCDHA3 ARP45338_P050 Q6INP1_XENLA MGC81522 protein Xenopus laevis (African clawed frog) 978 85.00% Xenopus tropicalis (Western clawed frog) PCDHA3 ARP45338_P050 Q6GL51_XENTR Protocadherin 8, gene 2 (Silurana tropicalis) 676 85.00% PCDHA3 ARP45338_P050 B5TR11_XENLA Paraxial protocadherin Xenopus laevis (African clawed frog) 979 85.00% PCDHA3 ARP45338_P050 Q284V9_XENLA Protocadherin PCNS Xenopus laevis (African clawed frog) 977 84.00% PCDHA3 ARP45338_P050 O93509_XENLA Paraxial protocadherin Xenopus laevis (African clawed frog) 979 78.00% PCDHA3 ARP45338_P050 Q6GLU2_XENLA MGC84237 protein Xenopus laevis (African clawed frog) 997 84.00% Ionotropic glutamate receptor subunit AVARP13060_T100 B9V8R8_XENLA GluR2(R)flop Xenopus laevis (African clawed frog) 882 100.00% Xenopus tropicalis (Western clawed frog) AVARP13060_T100 B4F6U0_XENTR Putative uncharacterized protein (Silurana tropicalis) 767 100.00% Xenopus tropicalis (Western clawed frog) ZFP28 ARP36281_P050 Q0P4L0_XENTR Putative uncharacterized protein MGC147120 (Silurana tropicalis) 500 83.00% Zinc finger protein Xfin (Xenopus fingers ZFP28 ARP36281_P050 XFIN_XENLA protein) (Xfin) Xenopus laevis (African clawed frog) 1350 100.00% TIA1 ARP40979_P050 Q90WN0_XENLA TIA‐1 protein (Fragment) Xenopus laevis (African clawed frog) 388 85.00% TIA1 cytotoxic ‐associated RNA binding Xenopus tropicalis (Western clawed frog) TIA1 ARP40979_P050 Q6P369_XENTR protein (Silurana tropicalis) 386 85.00% TIA1 ARP40979_P050 Q6DEF1_XENLA Putative uncharacterized protein Xenopus laevis (African clawed frog) 385 85.00% TIA1 ARP40979_P050 Q68EU5_XENLA MGC84540 protein Xenopus laevis (African clawed frog) 389 85.00% TIA1 cytotoxic granule‐associated RNA binding Xenopus tropicalis (Western clawed frog) TIA1 ARP40979_P050 Q28DR5_XENTR protein (Silurana tropicalis) 389 85.00% ORF Names:PHYPADRAFT_162267 EMBL EDQ75009.1OrganismPhyscomitrella Xenopus tropicalis (Western clawed frog) patens subsp. patens (Moss) ARP44835_P050 ACPL2_XENTR Acid phosphatase‐like protein 2 (EC 3.1.3.2) (Silurana tropicalis) 501 85.00% Trim23 ARP32672_P050 Q6DDN3_XENLA Trim23‐prov protein Xenopus laevis (African clawed frog) 588 84.00%

ORF Names:TRIADDRAFT_37081 EMBL EDV29814.1OrganismTrichoplax adhaerens (Trichoplax reptans) ARP51994_P050 Q7ZX80_XENLA Cyc1‐prov protein Xenopus laevis (African clawed frog) 309 92.00%

ORF Names:TRIADDRAFT_37081 EMBL EDV29814.1OrganismTrichoplax Xenopus tropicalis (Western clawed frog) adhaerens (Trichoplax reptans) ARP51994_P050 Q6P4K0_XENTR Putative uncharacterized protein MGC75973 (Silurana tropicalis) 309 92.00%

ORF Names:TRIADDRAFT_37081 EMBL EDV29814.1OrganismTrichoplax adhaerens (Trichoplax reptans) ARP51994_P050 Q4FZM5_XENLA MGC116545 protein Xenopus laevis (African clawed frog) 309 92.00% TAF5‐like RNA polymerase II, p300/CBP‐ associated factor (PCAF)‐associated factor, Xenopus tropicalis (Western clawed frog) Taf5l ARP32565_P050 Q6DIG0_XENTR 65kDa (Silurana tropicalis) 588 100.00% Taf5l ARP32565_P050 Q6DE31_XENLA Taf5l‐prov protein Xenopus laevis (African clawed frog) 587 100.00% Taf5l ARP32565_P050 Q32NS1_XENLA MGC130867 protein Xenopus laevis (African clawed frog) 588 100.00% Xenopus tropicalis (Western clawed frog) ARP50006_P050 A4IIR6_XENTR LOC100125046 protein (Fragment) (Silurana tropicalis) 923 90.00% ARP41675_T100 Q6PGS6_XENLA MGC64410 protein Xenopus laevis (African clawed frog) 496 90.00% ARP33998_P050 Q98SW0_XENLA P63 DNA binding protein Xenopus laevis (African clawed frog) 365 100.00% ARP33998_P050 Q6SEH3_XENLA P51/p63 (Fragment) Xenopus laevis (African clawed frog) 82 100.00% Xenopus tropicalis (Western clawed frog) ARP33998_P050 B1H2C8_XENTR LOC100145389 protein (Silurana tropicalis) 588 100.00% pyrD ARP41876_P050 Q6IR81_XENLA LOC432093 protein (Fragment) Xenopus laevis (African clawed frog) 406 78.00% Xenopus tropicalis (Western clawed frog) pyrD ARP41876_P050 Q5BKN2_XENTR MGC107816 protein (Silurana tropicalis) 401 78.00% pyrD ARP41876_P050 Q4QR42_XENLA LOC432093 protein Xenopus laevis (African clawed frog) 404 78.00% Mef2 ARP37342_T100 C0J6M6_XENLA MEF2A alpha 2 isoform Xenopus laevis (African clawed frog) 477 85.00% Mef2 ARP37342_T100 C0J6M5_XENLA MEF2A alpha 12b isoform Xenopus laevis (African clawed frog) 448 85.00% Myocyte‐specific enhancer factor 2A homolog (XMEF2A1) (xMEF2A) (Serum response factor‐ Mef2 ARP37342_T100 MEF2A_XENLA like protein 2) (SL‐2) Xenopus laevis (African clawed frog) 516 85.00% Fundc1 ARP53280_P050 Q6DFJ3_XENLA MGC82241 protein Xenopus laevis (African clawed frog) 188 100.00% Xenopus tropicalis (Western clawed frog) Fundc1 ARP53280_P050 B1H3B1_XENTR LOC100145592 protein (Silurana tropicalis) 151 100.00% Fundc1 ARP53280_P050 FUND1_XENLA FUN14 domain‐containing protein 1 Xenopus laevis (African clawed frog) 151 92.00% Pancreas‐specific transcription factor 1a Ptf1a ARP31839_T100 Q6UDE8_XENLA (Fragment) Xenopus laevis (African clawed frog) 267 92.00%

Pancreas transcription factor 1 subunit alpha (Pancreas‐specific transcription factor 1a) Ptf1a ARP31839_T100 PTF1A_XENLA (Transcription factor Ptf1a/p48) Xenopus laevis (African clawed frog) 270 92.00% Nphp1 ARP56084_P050 Q6INQ5_XENLA MGC81377 protein Xenopus laevis (African clawed frog) 683 100.00% Xenopus tropicalis (Western clawed frog) CNOT2 ARP32048_T100 A9JTQ3_XENTR LOC100127821 protein (Silurana tropicalis) 522 100.00% CNOT2 ARP32048_T100 Q6GPN8_XENLA LOC443622 protein (Fragment) Xenopus laevis (African clawed frog) 541 92.00% zfand5a ARP34465_P050 Q8AVE5_XENLA Awp1‐pending‐prov protein Xenopus laevis (African clawed frog) 204 92.00% Xenopus tropicalis (Western clawed frog) zfand5a ARP34465_P050 Q6P840_XENTR Zinc finger, AN1‐type domain 6 (Silurana tropicalis) 201 92.00% Xenopus tropicalis (Western clawed frog) zfand5a ARP34465_P050 Q07G77_XENTR Zinc finger, AN1‐type domain 6 (Silurana tropicalis) 203 92.00% zfand5a ARP34465_P050 Q6DF90_XENLA Za20d2‐prov protein Xenopus laevis (African clawed frog) 211 76.00% zfand5a ARP34465_P050 Q66IP3_XENLA MGC86388 protein Xenopus laevis (African clawed frog) 211 76.00% Xenopus tropicalis (Western clawed frog) zfand5a ARP34465_P050 Q28H17_XENTR Zinc finger, A20 domain containing 2 (Silurana tropicalis) 200 76.00% Xenopus tropicalis (Western clawed frog) zfand5a ARP34465_P050 Q05AS4_XENTR Zinc finger, AN1‐type domain 5 (Silurana tropicalis) 211 76.00% Xenopus tropicalis (Western clawed frog) zfand5a ARP34465_P050 B2GU64_XENTR Zinc finger, AN1‐type domain 5 (Silurana tropicalis) 211 76.00% SCFD1 ARP55851_P050 Q6GN05_XENLA MGC83661 protein Xenopus laevis (African clawed frog) 632 85.00% Xenopus tropicalis (Western clawed frog) SCFD1 ARP55851_P050 B4F6K9_XENTR Putative uncharacterized protein (Silurana tropicalis) 632 85.00% MEF2A ARP34223_P050 C0J6M6_XENLA MEF2A alpha 2 isoform Xenopus laevis (African clawed frog) 477 100.00% MEF2A ARP34223_P050 C0J6M5_XENLA MEF2A alpha 12b isoform Xenopus laevis (African clawed frog) 448 100.00% Myocyte‐specific enhancer factor 2A homolog (XMEF2A1) (xMEF2A) (Serum response factor‐ MEF2A ARP34223_P050 MEF2A_XENLA like protein 2) (SL‐2) Xenopus laevis (African clawed frog) 516 100.00% argH ARP41666_P050 Q66J94_XENLA MGC81570 protein Xenopus laevis (African clawed frog) 443 100.00% Xenopus tropicalis (Western clawed frog) argH ARP41666_P050 A9JTM9_XENTR LOC100127798 protein (Silurana tropicalis) 464 100.00% CG6554 ARP40198_T100 ANM1A_XENLA Isoform 2 Xenopus laevis (African clawed frog) 351 100.00% Protein arginine N‐methyltransferase 1 (EC 2.1.1.‐) (Heterogeneous nuclear ribonucleoprotein methyltransferase‐like protein 2) (Histone‐arginine N‐ Xenopus tropicalis (Western clawed frog) CG6554 ARP40198_T100 ANM1_XENTR methyltransferase PRMT1) (EC 2.1.1.125) (Silurana tropicalis) 351 100.00%

Protein arginine N‐methyltransferase 1‐B (xPRMT1b) (EC 2.1.1.‐) (Arginine methyltransferase 1b) (Histone‐arginine N‐ CG6554 ARP40198_T100 ANM1B_XENLA methyltransferase PRMT1‐B) (EC 2.1.1.125) Xenopus laevis (African clawed frog) 351 100.00%

Protein arginine N‐methyltransferase 1‐A (xPRMT1) (EC 2.1.1.‐) (Histone‐arginine N‐ CG6554 ARP40198_T100 ANM1A_XENLA methyltransferase PRMT1‐A) (EC 2.1.1.125) Xenopus laevis (African clawed frog) 369 100.00% Cyth1 ARP54947_P050 Q6GQ20_XENLA Pscd2 protein Xenopus laevis (African clawed frog) 233 90.00% Cyth1 ARP54947_P050 Q6GLR2_XENLA MGC84366 protein Xenopus laevis (African clawed frog) 397 90.00% Xenopus tropicalis (Western clawed frog) Cyth1 ARP54947_P050 Q6DF41_XENTR MGC89034 protein (Silurana tropicalis) 397 90.00% Cyth1 ARP54947_P050 Q6DCE0_XENLA LOC503678 protein Xenopus laevis (African clawed frog) 192 90.00% Xenopus tropicalis (Western clawed frog) DONSON ARP45862_P050 Q28CR1_XENTR Downstream neighbor of SON (Fragment) (Silurana tropicalis) 453 85.00% Xenopus tropicalis (Western clawed frog) DONSON ARP45862_P050 DONS_XENTR Protein downstream neighbor of son homolog (Silurana tropicalis) 577 85.00%

DONSON ARP45862_P050 DONS_XENLA Protein downstream neighbor of son homolog Xenopus laevis (African clawed frog) 579 85.00% Pccb ARP56116_P050 Q6P7H8_XENLA MGC68650 protein Xenopus laevis (African clawed frog) 541 100.00% Pccb ARP56116_P050 Q52L44_XENLA MGC68650 protein Xenopus laevis (African clawed frog) 541 100.00% Xenopus tropicalis (Western clawed frog) Pccb ARP56116_P050 Q4VA79_XENTR LOC613054 protein (Fragment) (Silurana tropicalis) 536 100.00% Xenopus tropicalis (Western clawed frog) Pccb ARP56116_P050 Q0VFV5_XENTR LOC613054 protein (Fragment) (Silurana tropicalis) 540 100.00% Xenopus tropicalis (Western clawed frog) ARP38652_T100 A4IHX4_XENTR Putative uncharacterized protein (Silurana tropicalis) 237 75.00%

Transcription initiation factor TFIID subunit 6 (xTAF6) (Transcription initiation factor TFIID 60 kDa subunit) (TAF(II)60) (TAFII‐60) (TAFII60) (Transcription initiation factor TFIID 70 kDa subunit) (TAF(II)70) (TAFII‐70) ARP38652_T100 TAF6_XENLA (TAFII70) Xenopus laevis (African clawed frog) 618 75.00% SNRPA1 ARP40441_T100 Q641E8_XENLA MGC81833 protein Xenopus laevis (African clawed frog) 255 78.00% RRP1B ARP45850_P050 Q801Q1_XENLA MGC53743 protein Xenopus laevis (African clawed frog) 613 78.00% Xenopus tropicalis (Western clawed frog) RRP1B ARP45850_P050 Q5BJ74_XENTR Rrp1b protein (Silurana tropicalis) 612 78.00% RRP1B ARP45850_P050 Q2VPH3_XENLA MGC53677 protein Xenopus laevis (African clawed frog) 611 78.00% Xenopus tropicalis (Western clawed frog) RRP1B ARP45850_P050 Q28CG7_XENTR Novel nuclear protein 1 (Silurana tropicalis) 612 78.00% ORF Names:ROS217_15745 EMBL EAQ24002.1OrganismRoseovarius sp. 217 ARP38934_P050 Q8JGN0_XENLA Stat1 Xenopus laevis (African clawed frog) 751 90.00% LOC100037080 ARP54683_P050 Q7ZX07_XENLA Lamr1‐prov protein Xenopus laevis (African clawed frog) 306 100.00% LOC100037080 ARP54683_P050 A2BDA2_XENLA LOC100037080 protein Xenopus laevis (African clawed frog) 295 100.00% 40S ribosomal protein SA (37 kDa laminin receptor precursor) (37LRP) (37/67 kDa laminin receptor) (LRP/LR) (67 kDa laminin receptor) (67LR) (Laminin receptor 1) (LamR) (Laminin‐binding protein precursor p40) Xenopus tropicalis (Western clawed frog) LOC100037080 ARP54683_P050 RSSA_XENTR (LBP/p40) (Silurana tropicalis) 306 100.00% 40S ribosomal protein SA (37 kDa laminin receptor precursor) (37LRP) (37/67 kDa laminin receptor) (LRP/LR) (67 kDa laminin receptor) (67LR) (Laminin receptor 1) (LamR) (Laminin‐binding protein precursor p40) LOC100037080 ARP54683_P050 RSSA_XENLA (LBP/p40) Xenopus laevis (African clawed frog) 306 92.00%

ORF Names:Aael_AAEL001205 EMBL ABM68581.1OrganismAedes aegypti Xenopus tropicalis (Western clawed frog) (Yellowfever mosquito) (Culex aegypti) ARP43086_P050 Q0VA08_XENTR Wwp2 protein (Silurana tropicalis) 729 92.00%

ORF Names:Aael_AAEL001205 EMBL ABM68581.1OrganismAedes aegypti Xenopus tropicalis (Western clawed frog) (Yellowfever mosquito) (Culex aegypti) ARP43086_P050 Q0P4P5_XENTR Wwp1 protein (Silurana tropicalis) 914 84.00% Xenopus tropicalis (Western clawed frog) PSEN2 ARP44289_P050 Q28HZ1_XENTR Presenilin 2 (Alzheimer disease 4) (Silurana tropicalis) 451 92.00% Presenilin‐2 (PS‐2) (EC 3.4.23.‐) (Presenilin PSEN2 ARP44289_P050 PSN2_XENLA beta) (PS‐beta) Xenopus laevis (African clawed frog) 449 84.00% Presenilin‐1 (PS‐1) (EC 3.4.23.‐) (Presenilin PSEN2 ARP44289_P050 PSN1_XENLA alpha) (PS‐alpha) Xenopus laevis (African clawed frog) 433 85.00% Xenopus tropicalis (Western clawed frog) PSEN2 ARP44289_P050 Q6P2Y8_XENTR Presenilin 1 (Silurana tropicalis) 433 85.00% .2 ARP37146_T100 Q90Z15_XENLA STAT5 Xenopus laevis (African clawed frog) 780 92.00% stat5.2 ARP37146_T100 Q6NU32_XENLA MGC81286 protein Xenopus laevis (African clawed frog) 781 92.00% stat5.2 ARP37146_T100 B7ZRD3_XENLA Stat5a protein Xenopus laevis (African clawed frog) 781 92.00% SWI/SNF‐related matrix‐associated actin‐ ORF Names:GSPATT00011615001 dependent regulator of chromatin subfamily A‐ EMBL like protein 1 (EC 3.6.4.‐) (HepA‐related CAK76014.1OrganismParamecium protein) (Sucrose nonfermenting protein 2‐ Xenopus tropicalis (Western clawed frog) tetraurelia ARP34311_P050 SMAL1_XENTR like 1) (Silurana tropicalis) 942 84.00% SWI/SNF‐related matrix‐associated actin‐ ORF Names:GSPATT00011615001 dependent regulator of chromatin subfamily A‐ EMBL like protein 1 (EC 3.6.4.‐) (HepA‐related CAK76014.1OrganismParamecium protein) (Sucrose nonfermenting protein 2‐ tetraurelia ARP34311_P050 SMAL1_XENLA like 1) Xenopus laevis (African clawed frog) 960 84.00% Xenopus tropicalis (Western clawed frog) SCGN ARP42333_P050 SEGN_XENTR Secretagogin (Silurana tropicalis) 271 83.00% SCGN ARP42333_P050 SEGN_XENLA Secretagogin Xenopus laevis (African clawed frog) 271 83.00% ORF Names:Bm1_41880 EMBL EDP31352.1OrganismBrugia malayi (Filarial nematode worm) ARP54975_P050 Q6VEU0_XENLA Nin one binding protein Xenopus laevis (African clawed frog) 442 92.00% ORF Names:Bm1_41880 EMBL EDP31352.1OrganismBrugia malayi (Filarial nematode worm) ARP54975_P050 Q5XHI8_XENLA LOC398701 protein Xenopus laevis (African clawed frog) 435 92.00% ORF Names:Bm1_41880 EMBL EDP31352.1OrganismBrugia malayi Xenopus tropicalis (Western clawed frog) (Filarial nematode worm) ARP54975_P050 Q5BJ63_XENTR Nob1p‐prov protein (Fragment) (Silurana tropicalis) 431 92.00% ORF Names:Bm1_41880 EMBL EDP31352.1OrganismBrugia malayi Xenopus tropicalis (Western clawed frog) (Filarial nematode worm) ARP54975_P050 Q28DH7_XENTR Novel protein (Silurana tropicalis) 436 92.00%

ORF Names:zgc:158681 ZFIN ZDB‐GENE‐ 070112‐332OrganismDanio rerio Xenopus tropicalis (Western clawed frog) (Zebrafish) (Brachydanio rerio) ARP34733_P050 B3DLJ0_XENTR LOC100170499 protein (Silurana tropicalis) 1970 100.00% ARP51697_P050 Q5U4M3_XENLA LOC495467 protein (Fragment) Xenopus laevis (African clawed frog) 581 91.00% chrnb2 ARP34970_T100 Q5XGU9_XENLA LOC495135 protein Xenopus laevis (African clawed frog) 499 78.00% Xenopus tropicalis (Western clawed frog) chrnb2 ARP34970_T100 A4IIS6_XENTR Chrnb2 protein (Silurana tropicalis) 499 78.00% TCF12 P100772_P050 Q91606_XENLA XE1.2 (Fragment) Xenopus laevis (African clawed frog) 160 91.00% TCF12 P100772_P050 Q641A7_XENLA Putative uncharacterized protein Xenopus laevis (African clawed frog) 684 91.00% TCF12 P100772_P050 Q5U248_XENLA LOC495689 protein Xenopus laevis (African clawed frog) 2428 84.00% sfrs6 ARP40632_P050 Q7ZWX1_XENLA MGC52985 protein Xenopus laevis (African clawed frog) 667 78.00% Xenopus tropicalis (Western clawed frog) sfrs6 ARP40632_P050 Q6NVB3_XENTR Splicing factor, arginine/serine‐rich 6 (Silurana tropicalis) 568 78.00% sfrs6 ARP40632_P050 Q7ZXT2_XENLA B52‐prov protein Xenopus laevis (African clawed frog) 660 78.00% ORF Proteasome (Prosome macropain) subunit Names:v1g165493OrganismNematostel alpha type 2 (Putative uncharacterized protein Xenopus tropicalis (Western clawed frog) la vectensis (Starlet sea anemone) ARP56453_P050 Q28GV0_XENTR LOC549136) (Silurana tropicalis) 234 92.00%

Proteasome subunit alpha type‐2 (EC 3.4.25.1) ORF (Macropain subunit C3) (Multicatalytic Names:v1g165493OrganismNematostel endopeptidase complex subunit C3) (xC3) la vectensis (Starlet sea anemone) ARP56453_P050 PSA2_XENLA (Proteasome component C3) Xenopus laevis (African clawed frog) 234 92.00%

ORF Names:CH211‐236K19.7‐001 EMBL CAM14104.1OrganismDanio rerio (Zebrafish) (Brachydanio rerio) ARP49452_P050 Q640H6_XENLA LOC494672 protein Xenopus laevis (African clawed frog) 809 100.00% KIN, antigenic determinant of recA protein Xenopus tropicalis (Western clawed frog) Kin ARP32295_T100 Q6GL97_XENTR homolog (Silurana tropicalis) 389 78.00% Kin ARP32295_T100 Q68F56_XENLA MGC81626 protein Xenopus laevis (African clawed frog) 387 78.00% Protein phosphatase 1K, mitochondrial (EC 3.1.3.16) (Protein phosphatase 2C isoform DKEY‐192D9.2 ARP53031_P050 PPM1K_XENLA kappa) (PP2C‐kappa) Xenopus laevis (African clawed frog) 373 100.00% dut ARP46027_T100 A2VDA3_XENLA LOC100037200 protein Xenopus laevis (African clawed frog) 164 78.00% P100732_P050 SOX8_XENLA Transcription factor Sox‐8 Xenopus laevis (African clawed frog) 459 76.00%

ORF Names:zgc:158361 ZFIN ZDB‐GENE‐ 061215‐64OrganismDanio rerio Phytanoyl‐CoA hydroxylase‐interacting Xenopus tropicalis (Western clawed frog) (Zebrafish) (Brachydanio rerio) ARP33877_P050 PHIPL_XENTR protein‐like (Silurana tropicalis) 376 84.00%

ORF Names:zgc:158361 ZFIN ZDB‐GENE‐ 061215‐64OrganismDanio rerio Phytanoyl‐CoA hydroxylase‐interacting (Zebrafish) (Brachydanio rerio) ARP33877_P050 PHIPL_XENLA protein‐like Xenopus laevis (African clawed frog) 376 84.00% PIGT ARP47202_P050 Q63ZU2_XENLA LOC494735 protein Xenopus laevis (African clawed frog) 578 85.00% Xenopus tropicalis (Western clawed frog) PIGT ARP47202_P050 Q499W8_XENTR Pigt protein (Pigt‐prov protein) (Fragment) (Silurana tropicalis) 575 85.00% Xenopus tropicalis (Western clawed frog) PIGT ARP47202_P050 A8WGV7_XENTR Pigt protein (Silurana tropicalis) 578 85.00% Cleavage and polyadenylation specific factor 5 (Nudix (Nucleoside diphosphate linked moiety Xenopus tropicalis (Western clawed frog) cpsf5 ARP40695_T100 Q28J89_XENTR X)‐type motif 21) (Silurana tropicalis) 227 100.00% Cleavage and polyadenylation specificity cpsf5 ARP40695_T100 CPSF5_XENLA factor subunit 5 Xenopus laevis (African clawed frog) 227 100.00% Glycoprotein endo‐alpha‐1,2‐mannosidase (EC ARP49845_P050 MANEA_XENLA 3.2.1.130) Xenopus laevis (African clawed frog) 449 90.00% Sodium/bile acid cotransporter 7‐B (Na(+)/bile acid cotransporter 7‐B) (Solute carrier family ARP43784_P050 NTP7B_XENLA 10 member 7‐B) (xP7) Xenopus laevis (African clawed frog) 343 92.00% Sodium/bile acid cotransporter 7‐A (Na(+)/bile acid cotransporter 7‐A) (Solute carrier family ARP43784_P050 NTP7A_XENLA 10 member 7‐A) Xenopus laevis (African clawed frog) 343 92.00% Sodium/bile acid cotransporter 7 (Na(+)/bile acid cotransporter 7) (Solute carrier family 10 Xenopus tropicalis (Western clawed frog) ARP43784_P050 NTCP7_XENTR member 7) (Silurana tropicalis) 343 92.00% Betaine‐‐homocysteine S‐methyltransferase 1 Xenopus tropicalis (Western clawed frog) Bhmt‐ps1 ARP41474_T100 BHMT1_XENTR (EC 2.1.1.5) (Silurana tropicalis) 403 92.00% Betaine‐‐homocysteine S‐methyltransferase 1 Bhmt‐ps1 ARP41474_T100 BHMT1_XENLA (EC 2.1.1.5) Xenopus laevis (African clawed frog) 403 92.00% TBPL2 P100971_T100 Q5I004_XENLA LOC503680 protein Xenopus laevis (African clawed frog) 296 100.00% Xenopus tropicalis (Western clawed frog) TBPL2 P100971_T100 B7ZUB8_XENTR TATA box binding protein (Silurana tropicalis) 297 100.00%

TATA‐box‐binding protein (TATA sequence‐ binding protein) (TATA‐binding factor) (TATA‐ box factor) (Transcription initiation factor Xenopus tropicalis (Western clawed frog) TBPL2 P100971_T100 TBP_XENTR TFIID TBP subunit) (Silurana tropicalis) 297 100.00%

TATA‐box‐binding protein (TATA sequence‐ binding protein) (TATA‐binding factor) (TATA‐ box factor) (Transcription initiation factor TBPL2 P100971_T100 TBP_XENLA TFIID TBP subunit) Xenopus laevis (African clawed frog) 297 100.00%

TATA box‐binding protein‐like protein 2 (TBP‐ like protein 2) (xTBPL2) (TATA box‐binding Xenopus tropicalis (Western clawed frog) TBPL2 P100971_T100 TBPL2_XENTR protein‐related factor 3) (TBP‐related factor 3) (Silurana tropicalis) 322 100.00%

TATA box‐binding protein‐like protein 2 (TBP‐ like protein 2) (TATA box‐binding protein‐ TBPL2 P100971_T100 TBPL2_XENLA related factor 3) (TBP‐related factor 3) Xenopus laevis (African clawed frog) 320 100.00% Transcription factor Sox‐14 (SRY (sex Sox14 ARP35712_T100 SOX14_XENLA determining region Y)‐box 14) Xenopus laevis (African clawed frog) 239 85.00% Transcription factor Sox‐14 (SRY (sex Xenopus tropicalis (Western clawed frog) Sox14 ARP35712_T100 SOX14_XENTR determining region Y)‐box 14) (Silurana tropicalis) 239 100.00% Xenopus tropicalis (Western clawed frog) grma ARP31907_P050 A8KBG5_XENTR LOC100127664 protein (Silurana tropicalis) 909 78.00% ORF Names:GSPATT00003587001 EMBL CAK90724.1OrganismParamecium tetraurelia ARP41433_T100 Q6NTU0_XENLA MGC82246 protein Xenopus laevis (African clawed frog) 221 85.00% ORF Names:GSPATT00003587001 EMBL CAK90724.1OrganismParamecium tetraurelia ARP41433_T100 Q4V864_XENLA MGC114646 protein Xenopus laevis (African clawed frog) 221 85.00% ORF Names:GSPATT00003587001 EMBL CAK90724.1OrganismParamecium Xenopus tropicalis (Western clawed frog) tetraurelia ARP41433_T100 B0JZR2_XENTR LOC100145221 protein (Silurana tropicalis) 214 78.00% ARP36347_P050 Q6NU35_XENLA MGC81281 protein Xenopus laevis (African clawed frog) 761 100.00% Xenopus tropicalis (Western clawed frog) ARP36347_P050 B4F700_XENTR Putative uncharacterized protein (Silurana tropicalis) 761 100.00% ORF Names:Smp_016780 EMBL CAZ29378.1OrganismSchistosoma mansoni (Blood fluke) ARP53650_P050 Q91831_XENLA Alpha‐tubulin Xenopus laevis (African clawed frog) 450 100.00% ORF Names:Smp_016780 EMBL CAZ29378.1OrganismSchistosoma mansoni (Blood fluke) ARP53650_P050 Q7ZYU9_XENLA Alphatub84b‐prov protein Xenopus laevis (African clawed frog) 452 100.00% ORF Names:Smp_016780 EMBL CAZ29378.1OrganismSchistosoma mansoni (Blood fluke) ARP53650_P050 Q7ZWQ5_XENLA Tuba6‐prov protein Xenopus laevis (African clawed frog) 449 100.00% ORF Names:Smp_016780 EMBL CAZ29378.1OrganismSchistosoma mansoni (Blood fluke) ARP53650_P050 Q7ZTP0_XENLA MGC53359 protein Xenopus laevis (African clawed frog) 450 100.00% ORF Names:Smp_016780 EMBL CAZ29378.1OrganismSchistosoma Xenopus tropicalis (Western clawed frog) mansoni (Blood fluke) ARP53650_P050 Q6P8G7_XENTR Tubulin, alpha 1c (Tubulin, alpha 6) (Silurana tropicalis) 449 100.00% ORF Names:Smp_016780 EMBL CAZ29378.1OrganismSchistosoma Xenopus tropicalis (Western clawed frog) mansoni (Blood fluke) ARP53650_P050 Q6P8D2_XENTR Tubulin, alpha 1 (Silurana tropicalis) 451 100.00% ORF Names:Smp_016780 EMBL CAZ29378.1OrganismSchistosoma Xenopus tropicalis (Western clawed frog) mansoni (Blood fluke) ARP53650_P050 Q6NVN1_XENTR Tubulin, alpha 2 (Tubulin, alpha 4) (Silurana tropicalis) 450 100.00% ORF Names:Smp_016780 EMBL CAZ29378.1OrganismSchistosoma mansoni (Blood fluke) ARP53650_P050 Q6NRV3_XENLA MGC81323 protein Xenopus laevis (African clawed frog) 450 100.00% ORF Names:Smp_016780 EMBL CAZ29378.1OrganismSchistosoma mansoni (Blood fluke) ARP53650_P050 Q6GQC3_XENLA Tuba8 protein Xenopus laevis (African clawed frog) 456 100.00% ORF Names:Smp_016780 EMBL CAZ29378.1OrganismSchistosoma mansoni (Blood fluke) ARP53650_P050 Q5U4V6_XENLA LOC397931 protein Xenopus laevis (African clawed frog) 450 100.00% ORF Names:Smp_016780 EMBL CAZ29378.1OrganismSchistosoma Xenopus tropicalis (Western clawed frog) mansoni (Blood fluke) ARP53650_P050 Q5EB23_XENTR MGC97820 protein (Silurana tropicalis) 449 100.00% ORF Names:Smp_016780 EMBL CAZ29378.1OrganismSchistosoma Xenopus tropicalis (Western clawed frog) mansoni (Blood fluke) ARP53650_P050 Q28CR6_XENTR Tubulin, alpha 2 (Fragment) (Silurana tropicalis) 442 100.00% ORF Names:Smp_016780 EMBL CAZ29378.1OrganismSchistosoma Novel protein similar to tubulin, alpha 1 Xenopus tropicalis (Western clawed frog) mansoni (Blood fluke) ARP53650_P050 Q28CH9_XENTR (Tuba1) (Silurana tropicalis) 414 100.00% ORF Names:Smp_016780 EMBL CAZ29378.1OrganismSchistosoma Novel protein similar to tubulin, alpha 1 Xenopus tropicalis (Western clawed frog) mansoni (Blood fluke) ARP53650_P050 Q28C42_XENTR (Tuba1) (Silurana tropicalis) 449 100.00% ORF Names:Smp_016780 EMBL CAZ29378.1OrganismSchistosoma Xenopus tropicalis (Western clawed frog) mansoni (Blood fluke) ARP53650_P050 B7ZTG2_XENTR Tubulin, alpha 4b (Silurana tropicalis) 449 100.00% ORF Names:Smp_016780 EMBL CAZ29378.1OrganismSchistosoma Xenopus tropicalis (Western clawed frog) mansoni (Blood fluke) ARP53650_P050 B0BMH2_XENTR Tuba4a protein (Silurana tropicalis) 451 100.00% ORF Names:Smp_016780 EMBL CAZ29378.1OrganismSchistosoma Novel protein similar to tubulin, alpha 1 Xenopus tropicalis (Western clawed frog) mansoni (Blood fluke) ARP53650_P050 A4IGU4_XENTR (Tuba1) (Silurana tropicalis) 449 100.00% ORF Names:Smp_016780 EMBL CAZ29378.1OrganismSchistosoma mansoni (Blood fluke) ARP53650_P050 A2RV72_XENLA LOC100037141 protein Xenopus laevis (African clawed frog) 449 100.00% ORF Names:Smp_016780 EMBL CAZ29378.1OrganismSchistosoma mansoni (Blood fluke) ARP53650_P050 A1L2T2_XENLA LOC100036943 protein Xenopus laevis (African clawed frog) 456 100.00% ARP52212_P050 Q6GNS6_XENLA MGC80911 protein Xenopus laevis (African clawed frog) 678 85.00% DENN domain‐containing protein 1A ARP52771_P050 DEN1A_XENLA (Connecdenn) Xenopus laevis (African clawed frog) 1010 83.00% ARP52771_P050 Q6DCI3_XENLA LOC446246 protein (Fragment) Xenopus laevis (African clawed frog) 730 75.00% Xenopus tropicalis (Western clawed frog) ARP44241_T100 Q0IHS4_XENTR Gamma sarcoglycan (Silurana tropicalis) 296 92.00% Xenopus tropicalis (Western clawed frog) Ovol2 ARP33204_P050 Q6DIE9_XENTR Ovo‐like 2 (Ovo‐like 2 (Drosophila)) (Silurana tropicalis) 287 91.00% Xenopus tropicalis (Western clawed frog) mypop P100709_P050 B4F6L5_XENTR Putative uncharacterized protein (Silurana tropicalis) 340 92.00%

Myb‐related transcription factor, partner of mypop P100709_P050 MYPOP_XENLA profilin (Myb‐related protein p42POP) Xenopus laevis (African clawed frog) 341 92.00% ap3m2 ARP52255_P050 Q5PPX3_XENLA LOC496052 protein Xenopus laevis (African clawed frog) 418 92.00% Adaptor‐related protein complex 3, mu 2 Xenopus tropicalis (Western clawed frog) ap3m2 ARP52255_P050 Q28IJ4_XENTR subunit (Silurana tropicalis) 418 92.00% Myogenic specification paired‐box PAX7 ARP32068_P050 Q645N6_XENLA transcription factor Pax7 Xenopus laevis (African clawed frog) 500 83.00% PAX7 ARP32068_P050 B7ZRC7_XENLA LOC496378 protein Xenopus laevis (African clawed frog) 501 83.00% PAX7 ARP32068_P050 PAX3A_XENLA Isoform 2 Xenopus laevis (African clawed frog) 460 75.00% Paired box protein Pax‐3 (Paired‐domain Xenopus tropicalis (Western clawed frog) PAX7 ARP32068_P050 PAX3_XENTR transcription factor Pax3) (Silurana tropicalis) 461 75.00%

Paired box protein Pax‐3‐A (xPax3‐A) (Paired‐ PAX7 ARP32068_P050 PAX3A_XENLA domain transcription factor Pax3‐A) Xenopus laevis (African clawed frog) 484 75.00% ORF Names:ACLA_092240 EMBL EAW11526.1OrganismAspergillus clavatus ARP54262_P050 Q6PGS1_XENLA MGC64432 protein Xenopus laevis (African clawed frog) 454 92.00% ORF Names:ACLA_092240 EMBL EAW11526.1OrganismAspergillus Xenopus tropicalis (Western clawed frog) clavatus ARP54262_P050 Q66KM6_XENTR Sqstm1 protein (Silurana tropicalis) 452 92.00% siat6 ARP46705_T100 Q70D55_XENLA Alpha2,3‐sialyltransferase (EC 2.4.99.6) Xenopus laevis (African clawed frog) 360 85.00% Xenopus tropicalis (Western clawed frog) siat6 ARP46705_T100 Q702R6_XENTR Alpha‐2,3‐sialyltransferase ST3Gal III (Silurana tropicalis) 358 85.00% Xenopus tropicalis (Western clawed frog) siat6 ARP46705_T100 Q0P4X4_XENTR St3gal3 protein (Silurana tropicalis) 415 85.00% siat6 ARP46705_T100 B7ZQA7_XENLA St3Gal‐III protein Xenopus laevis (African clawed frog) 360 85.00% Xenopus tropicalis (Western clawed frog) siat6 ARP46705_T100 A4IGP6_XENTR Siat6 protein (Silurana tropicalis) 374 85.00% WD repeat domain phosphoinositide‐ ORF interacting protein 3 (WIPI‐3) (WD repeat‐ Names:v1g172497OrganismNematostel containing protein 45‐like) (WDR45‐like Xenopus tropicalis (Western clawed frog) la vectensis (Starlet sea anemone) ARP34826_P050 WIPI3_XENTR protein) (Silurana tropicalis) 344 92.00% WD repeat domain phosphoinositide‐ ORF interacting protein 3 (WIPI‐3) (WD repeat‐ Names:v1g172497OrganismNematostel containing protein 45‐like) (WDR45‐like la vectensis (Starlet sea anemone) ARP34826_P050 WIPI3_XENLA protein) Xenopus laevis (African clawed frog) 344 92.00% Gpsm2 ARP51303_P050 Q8AVU7_XENLA Gpsm2 protein Xenopus laevis (African clawed frog) 336 92.00% Gpsm2 ARP51303_P050 Q6DDN8_XENLA MGC82643 protein Xenopus laevis (African clawed frog) 217 84.00% Xenopus tropicalis (Western clawed frog) Gpsm2 ARP51303_P050 A4III0_XENTR Gpsm1 protein (Silurana tropicalis) 658 84.00% ORF Names:ACLA_036360 EMBL EAW09432.1OrganismAspergillus clavatus ARP48396_T100 Q7SYQ9_XENLA PP protein (Fragment) Xenopus laevis (African clawed frog) 308 100.00% ORF Names:ACLA_036360 EMBL EAW09432.1OrganismAspergillus clavatus ARP48396_T100 Q6GN00_XENLA MGC83669 protein Xenopus laevis (African clawed frog) 289 100.00% ORF Names:ACLA_036360 EMBL EAW09432.1OrganismAspergillus Hypothetical LOC496951 (Pyrophosphatase Xenopus tropicalis (Western clawed frog) clavatus ARP48396_T100 Q5I093_XENTR (Inorganic)) (Silurana tropicalis) 289 100.00% ORF Names:ACLA_036360 EMBL EAW09432.1OrganismAspergillus clavatus ARP48396_T100 Q32NU1_XENLA Putative uncharacterized protein Xenopus laevis (African clawed frog) 289 100.00% ORF Names:ACLA_036360 EMBL EAW09432.1OrganismAspergillus clavatus ARP48396_T100 Q6NRU5_XENLA MGC81379 protein Xenopus laevis (African clawed frog) 304 78.00% ORF Names:ACLA_036360 EMBL EAW09432.1OrganismAspergillus Xenopus tropicalis (Western clawed frog) clavatus ARP48396_T100 Q28H25_XENTR Inorganic pyrophosphatase 2 (Silurana tropicalis) 335 78.00% ORF Names:ACLA_036360 EMBL EAW09432.1OrganismAspergillus Xenopus tropicalis (Western clawed frog) clavatus ARP48396_T100 B4F6Y8_XENTR Putative uncharacterized protein (Fragment) (Silurana tropicalis) 203 78.00% ORF Names:ACLA_036360 EMBL EAW09432.1OrganismAspergillus Xenopus tropicalis (Western clawed frog) clavatus ARP48396_T100 A4II39_XENTR Pyp protein (Fragment) (Silurana tropicalis) 329 78.00% ORF Names:ACLA_036360 EMBL EAW09432.1OrganismAspergillus clavatus ARP48396_T100 Q4QQZ1_XENLA MGC115504 protein Xenopus laevis (African clawed frog) 204 78.00%

ORF Names:GSTENG00013639001 Transcriptional adapter 3 (ADA3 homolog) EMBL CAF96555.1OrganismTetraodon (Transcriptional adapter 3‐like) (ADA3‐like Xenopus tropicalis (Western clawed frog) nigroviridis (Green puffer) ARP32767_P050 TADA3_XENTR protein) (Silurana tropicalis) 432 84.00%

ORF Names:GSTENG00013639001 Transcriptional adapter 3‐B (ADA3 homolog B) EMBL CAF96555.1OrganismTetraodon (Transcriptional adapter 3‐like B) (ADA3‐like nigroviridis (Green puffer) ARP32767_P050 TAD3B_XENLA protein B) Xenopus laevis (African clawed frog) 432 84.00%

ORF Names:GSTENG00013639001 Transcriptional adapter 3‐A (ADA3 homolog A) EMBL CAF96555.1OrganismTetraodon (Transcriptional adapter 3‐like A) (ADA3‐like nigroviridis (Green puffer) ARP32767_P050 TAD3A_XENLA protein A) Xenopus laevis (African clawed frog) 432 76.00% Zinc finger protein Xfin (Xenopus fingers ZNF167 ARP47501_P050 XFIN_XENLA protein) (Xfin) Xenopus laevis (African clawed frog) 1350 100.00% DKK2 ARP48015_T100 O57464_XENLA Dickkopf homolog 1 (Xdkk‐1) Xenopus laevis (African clawed frog) 259 100.00% Xenopus tropicalis (Western clawed frog) DKK2 ARP48015_T100 A9ULN0_XENTR Dickkopf 1 (Silurana tropicalis) 257 100.00% DKK2 ARP48015_T100 Q9DDA4_XENLA Dickkopf homolog 2 (Dickkopf2) Xenopus laevis (African clawed frog) 255 84.00% ORF Names:PANDA_016430 EMBL EFB15692.1OrganismAiluropoda Xenopus tropicalis (Western clawed frog) melanoleuca (Giant panda) ARP44441_P050 Q5EBF4_XENTR MGC108303 protein (Silurana tropicalis) 693 78.00% ORF Names:M23134_05740 EMBL EAY29867.1OrganismMicroscilla marina Xenopus tropicalis (Western clawed frog) ATCC 23134 ARP48390_T100 A9ULJ7_XENTR Leucine zipper transcription factor‐like 1 (Silurana tropicalis) 315 100.00% ORF Names:M23134_05740 EMBL EAY29867.1OrganismMicroscilla marina Xenopus tropicalis (Western clawed frog) ATCC 23134 ARP48390_T100 A4IHW9_XENTR Lztfl1 protein (Silurana tropicalis) 243 100.00% Xenopus tropicalis (Western clawed frog) P100946_T100 Q28IY7_XENTR Jun B proto‐oncogene (Silurana tropicalis) 307 100.00% junb P100946_T100 A0JMS2_XENLA Junb protein Xenopus laevis (African clawed frog) 295 100.00% junb P100946_T100 Q6INQ8_XENLA MGC81322 protein Xenopus laevis (African clawed frog) 302 100.00% Xenopus tropicalis (Western clawed frog) foxj3 ARP32288_P050 A8E4V8_XENTR Foxj3 protein (Silurana tropicalis) 603 76.00% Xenopus tropicalis (Western clawed frog) RXRb1 ARP38881_T100 Q0IIU2_XENTR LOC779621 protein (Fragment) (Silurana tropicalis) 452 100.00% RXRb1 ARP38881_T100 Q5HZR5_XENLA LOC496325 protein Xenopus laevis (African clawed frog) 470 92.00% RXRb1 ARP38881_T100 Q4KLS2_XENLA MGC115510 protein Xenopus laevis (African clawed frog) 471 92.00% Retinoic acid receptor RXR‐gamma (Nuclear receptor subfamily 2 group B member 3) RXRb1 ARP38881_T100 RXRG_XENLA (Retinoid X receptor gamma) Xenopus laevis (African clawed frog) 470 92.00% Retinoic acid receptor RXR‐alpha (Nuclear receptor subfamily 2 group B member 1) RXRb1 ARP38881_T100 RXRA_XENLA (Retinoid X receptor alpha) Xenopus laevis (African clawed frog) 488 100.00% RXRb1 ARP38881_T100 Q91840_XENLA Retinoid X receptor beta Xenopus laevis (African clawed frog) 412 84.00% RXRb1 ARP38881_T100 Q91613_XENLA XRXR beta Xenopus laevis (African clawed frog) 452 84.00% RXRb1 ARP38881_T100 Q6INZ0_XENLA Rxrb protein Xenopus laevis (African clawed frog) 449 84.00% RXRb1 ARP38881_T100 Q6GPF8_XENLA Rxrb‐A‐prov protein (Fragment) Xenopus laevis (African clawed frog) 451 84.00% RXRb1 ARP38881_T100 Q4FZW9_XENLA Rxrb‐A‐prov protein (Fragment) Xenopus laevis (African clawed frog) 458 84.00% RXRb1 ARP38881_T100 Q2VPP3_XENLA Rxrb‐a protein (Fragment) Xenopus laevis (African clawed frog) 458 84.00% Retinoic acid receptor RXR‐beta (Retinoid X Xenopus tropicalis (Western clawed frog) RXRb1 ARP38881_T100 Q28CI3_XENTR receptor beta) (Silurana tropicalis) 449 84.00% RXRb1 ARP38881_T100 B7FEW3_XENLA Rxrb‐a protein (Fragment) Xenopus laevis (African clawed frog) 445 84.00% Xenopus tropicalis (Western clawed frog) RXRb1 ARP38881_T100 B3DLT9_XENTR Rxrb protein (Silurana tropicalis) 412 84.00% Xenopus tropicalis (Western clawed frog) SH3RF1 ARP43283_P050 B7ZTV8_XENTR Sh3md2 protein (Silurana tropicalis) 861 85.00% Putative E3 ubiquitin‐protein ligase SH3RF1 (EC 6.3.2.‐) (Plenty of SH3s) (Protein POSH) (SH3 domain‐containing RING finger protein Xenopus tropicalis (Western clawed frog) SH3RF1 ARP43283_P050 SH3R1_XENTR 1) (Silurana tropicalis) 861 85.00% Putative E3 ubiquitin‐protein ligase SH3RF1 (EC 6.3.2.‐) (Plenty of SH3s) (Protein POSH) (xPOSH) (SH3 domain‐containing RING finger SH3RF1 ARP43283_P050 SH3R1_XENLA protein 1) Xenopus laevis (African clawed frog) 826 85.00% Kidney mitochondrial carrier protein 1 (Solute Xenopus tropicalis (Western clawed frog) Slc25a14 ARP43861_T100 KMCP1_XENTR carrier family 25 member 30) (Silurana tropicalis) 291 85.00% Kidney mitochondrial carrier protein 1 (Solute Slc25a14 ARP43861_T100 KMCP1_XENLA carrier family 25 member 30) Xenopus laevis (African clawed frog) 291 85.00% VDAC2 ARP35180_P050 Q6GR11_XENLA MGC81430 protein Xenopus laevis (African clawed frog) 283 92.00% Xenopus tropicalis (Western clawed frog) VDAC2 ARP35180_P050 Q5M8U0_XENTR Voltage‐dependent anion channel 3 (Silurana tropicalis) 283 91.00% VDAC2 ARP35180_P050 Q52KY1_XENLA Vdac2 protein Xenopus laevis (African clawed frog) 283 78.00% Xenopus tropicalis (Western clawed frog) VDAC2 ARP35180_P050 Q07G51_XENTR Voltage‐dependent anion channel 2 (Silurana tropicalis) 283 78.00% Voltage‐dependent anion‐selective channel protein 2 (VDAC‐2) (Outer mitochondrial VDAC2 ARP35180_P050 VDAC2_XENLA membrane protein porin) Xenopus laevis (African clawed frog) 282 78.00% ARP42255_T100 Q7ZX95_XENLA LOC398502 protein (Fragment) Xenopus laevis (African clawed frog) 497 100.00% ARP42255_T100 Q6NRZ2_XENLA LOC398502 protein Xenopus laevis (African clawed frog) 491 100.00%

Nicotinamide phosphoribosyltransferase (Pre Xenopus tropicalis (Western clawed frog) ARP42255_T100 Q5M7L4_XENTR B cell colony enhancing factor 1) (Silurana tropicalis) 491 100.00% ARP42255_T100 Q5FWL1_XENLA MGC85013 protein Xenopus laevis (African clawed frog) 491 100.00% Btbd6 ARP34647_P050 A8E625_XENLA P7E4 protein (Fragment) Xenopus laevis (African clawed frog) 423 92.00% Xenopus tropicalis (Western clawed frog) Btbd6 ARP34647_P050 BTBD6_XENTR BTB/POZ domain‐containing protein 6 (Silurana tropicalis) 529 92.00% Btbd6 ARP34647_P050 BTBD6_XENLA BTB/POZ domain‐containing protein 6 Xenopus laevis (African clawed frog) 529 92.00% HSPA2 ARP33096_T100 Q6GMF1_XENLA MGC81782 protein Xenopus laevis (African clawed frog) 634 100.00% HSPA2 ARP33096_T100 Q6DCD3_XENLA Hsp70 protein Xenopus laevis (African clawed frog) 647 100.00% Xenopus tropicalis (Western clawed frog) HSPA2 ARP33096_T100 A9JTJ5_XENTR Hsp70 protein (Silurana tropicalis) 643 100.00% Xenopus tropicalis (Western clawed frog) HSPA2 ARP33096_T100 A4IGS8_XENTR Hsp70 protein (Fragment) (Silurana tropicalis) 507 100.00% HSPA2 ARP33096_T100 HSP70_XENLA Heat shock 70 kDa protein (HSP70) Xenopus laevis (African clawed frog) 647 100.00% HSPA2 ARP33096_T100 Q6AZH8_XENLA Putative uncharacterized protein Xenopus laevis (African clawed frog) 652 92.00% Xenopus tropicalis (Western clawed frog) HSPA2 ARP33096_T100 Q0V9A5_XENTR Heat shock 70kDa protein 1‐like (Silurana tropicalis) 639 92.00% HSPA2 ARP33096_T100 A1L3K5_XENLA LOC100037033 protein Xenopus laevis (African clawed frog) 646 92.00% Xenopus tropicalis (Western clawed frog) Styk1 ARP47449_P050 B3DLS0_XENTR LOC100170540 protein (Silurana tropicalis) 419 91.00% ATP‐dependent RNA helicase DDX1 (EC Xenopus tropicalis (Western clawed frog) ddx1 ARP36378_P050 DDX1_XENTR 3.6.4.13) (DEAD box protein 1) (Silurana tropicalis) 740 100.00% ATP‐dependent RNA helicase DDX1 (EC ddx1 ARP36378_P050 DDX1_XENLA 3.6.4.13) (DEAD box protein 1) Xenopus laevis (African clawed frog) 740 100.00% Xenopus tropicalis (Western clawed frog) gloB ARP56810_P050 LACB2_XENTR Beta‐lactamase‐like protein 2 (EC 3.‐.‐.‐) (Silurana tropicalis) 289 100.00% gloB ARP56810_P050 LACB2_XENLA Beta‐lactamase‐like protein 2 (EC 3.‐.‐.‐) Xenopus laevis (African clawed frog) 287 100.00% Homeobox protein Nkx‐3.2 (Bagpipe ARP36826_P050 NKX32_XENLA homeobox protein homolog 1) (Xbap) Xenopus laevis (African clawed frog) 329 92.00% Transcription factor LBX1 (Ladybird homeobox Xenopus tropicalis (Western clawed frog) ARP36826_P050 LBX1_XENTR protein homolog 1) (Silurana tropicalis) 265 83.00% Transcription factor LBX1 (Ladybird homeobox ARP36826_P050 LBX1_XENLA protein homolog 1) Xenopus laevis (African clawed frog) 267 83.00% Homeobox protein Nkx‐3.2 (Bagpipe Nkx3‐2 ARP33199_P050 NKX32_XENLA homeobox protein homolog 1) (Xbap) Xenopus laevis (African clawed frog) 329 84.00% Xenopus tropicalis (Western clawed frog) ldlrap1b ARP55308_P050 Q28GW3_XENTR OTTXETP00000000331 (Silurana tropicalis) 309 100.00% Xenopus tropicalis (Western clawed frog) ldlrap1b ARP55308_P050 A9ULP2_XENTR Putative uncharacterized protein LOC549868 (Silurana tropicalis) 309 100.00% Low density lipoprotein receptor adapter protein 1‐B (Autosomal recessive hypercholesterolemia protein homolog beta) ldlrap1b ARP55308_P050 ARHB_XENLA (ARH beta) (xARH beta) Xenopus laevis (African clawed frog) 309 100.00%

Low density lipoprotein receptor adapter protein 1‐A (Autosomal recessive hypercholesterolemia protein homolog alpha) (ARH alpha) (xARH alpha) (Phosphotyrosine‐ ldlrap1b ARP55308_P050 ARHA_XENLA binding protein) (Xcat4) Xenopus laevis (African clawed frog) 309 100.00% Xenopus tropicalis (Western clawed frog) ACTN3 ARP58413_P050 Q05AR8_XENTR Actinin, alpha 1 (Silurana tropicalis) 885 76.00% Xenopus tropicalis (Western clawed frog) ACTN3 ARP58413_P050 B4F6H3_XENTR Putative uncharacterized protein (Silurana tropicalis) 298 76.00% ACTN3 ARP58413_P050 Q7ZY34_XENLA ACTN1 protein Xenopus laevis (African clawed frog) 890 76.00% Xenopus tropicalis (Western clawed frog) ACTN3 ARP58413_P050 Q6DFP7_XENTR Actinin, alpha 4 (Silurana tropicalis) 904 81.00% Xenopus tropicalis (Western clawed frog) ACTN3 ARP58413_P050 B4F6M1_XENTR Putative uncharacterized protein (Silurana tropicalis) 896 83.00% ACTN3 ARP58413_P050 Q6DD73_XENLA MGC79035 protein Xenopus laevis (African clawed frog) 894 75.00% ACTN3 ARP58413_P050 Q6DFU3_XENLA Actn3‐prov protein Xenopus laevis (African clawed frog) 896 81.00% ELK3 P100855_P050 Q7T0T1_XENLA Elk3‐prov protein Xenopus laevis (African clawed frog) 446 78.00% ELK3, ETS‐domain protein (SRF accessory Xenopus tropicalis (Western clawed frog) ELK3 P100855_P050 Q0IHT9_XENTR protein 2) (Silurana tropicalis) 421 78.00% Eukaryotic translation initiation factor 3 subunit G (eIF3g) (Eukaryotic translation ORF Names:OsI_09222 EMBL initiation factor 3 RNA‐binding subunit) (eIF‐3 EAY87803.1OrganismOryza sativa RNA‐binding subunit) (Eukaryotic translation Xenopus tropicalis (Western clawed frog) subsp. indica (Rice) ARP40485_P050 EIF3G_XENTR initiation factor 3 subunit 4) (Silurana tropicalis) 310 100.00%

Eukaryotic translation initiation factor 3 subunit G‐B (eIF3g‐B) (Eukaryotic translation ORF Names:OsI_09222 EMBL initiation factor 3 RNA‐binding subunit B) (eIF‐ EAY87803.1OrganismOryza sativa 3 RNA‐binding subunit B) (Eukaryotic subsp. indica (Rice) ARP40485_P050 EI3GB_XENLA translation initiation factor 3 subunit 4‐B) Xenopus laevis (African clawed frog) 308 100.00%

Eukaryotic translation initiation factor 3 subunit G‐A (eIF3g‐A) (Eukaryotic translation ORF Names:OsI_09222 EMBL initiation factor 3 RNA‐binding subunit A) (eIF‐ EAY87803.1OrganismOryza sativa 3 RNA‐binding subunit A) (Eukaryotic subsp. indica (Rice) ARP40485_P050 EI3GA_XENLA translation initiation factor 3 subunit 4‐A) Xenopus laevis (African clawed frog) 308 100.00% ORF Names:PICST_35884 EMBL ABN66071.2OrganismPichia stipitis Xenopus tropicalis (Western clawed frog) (Yeast) ARP41068_P050 B0BM69_XENTR Zcrb1 protein (Silurana tropicalis) 215 92.00% Zinc finger CCHC‐type and RNA‐binding motif‐ ORF Names:PICST_35884 EMBL containing protein 1 (U11/U12 small nuclear ABN66071.2OrganismPichia stipitis ribonucleoprotein 31 kDa protein) (U11/U12 (Yeast) ARP41068_P050 ZCRB1_XENLA snRNP 31 kDa protein) Xenopus laevis (African clawed frog) 218 92.00% ARP55333_P050 Q4V7U5_XENLA MGC115384 protein Xenopus laevis (African clawed frog) 297 100.00% Novel protein (Putative uncharacterized Xenopus tropicalis (Western clawed frog) ARP55333_P050 Q28J68_XENTR protein LOC549485) (Silurana tropicalis) 297 100.00% ARP55333_P050 Q58E85_XENLA MGC84965 protein Xenopus laevis (African clawed frog) 297 92.00%

ORF Names:v1g90352OrganismNematostell Xenopus tropicalis (Western clawed frog) a vectensis (Starlet sea anemone) ARP38618_P050 B5DEA1_XENTR Putative uncharacterized protein (Silurana tropicalis) 388 92.00%

ORF Names:v1g90352OrganismNematostell T‐cell acute lymphocytic leukemia protein 1 a vectensis (Starlet sea anemone) ARP38618_P050 TAL1_XENLA (TAL‐1) (Stem cell leukemia protein SCL) (xSCL) Xenopus laevis (African clawed frog) 394 92.00% Guanine nucleotide binding protein, alpha Xenopus tropicalis (Western clawed frog) Golf ARP41765_T100 Q6NVN4_XENTR stimulating, olfactory type (Silurana tropicalis) 379 84.00% Golf ARP41765_T100 B7ZR45_XENLA GNAS complex locus Xenopus laevis (African clawed frog) 379 85.00% Guanine nucleotide‐binding protein G(s) subunit alpha (Adenylate cyclase‐stimulating Golf ARP41765_T100 GNAS_XENLA G alpha protein) Xenopus laevis (African clawed frog) 379 85.00% MGC68706 protein (Putative uncharacterized Golf ARP41765_T100 Q6P413_XENLA protein MGC68706) Xenopus laevis (African clawed frog) 379 78.00% ARP48239_P050 Q6GNX3_XENLA Xdrg protein Xenopus laevis (African clawed frog) 334 100.00% Developmentally regulated GTP binding Xenopus tropicalis (Western clawed frog) ARP48239_P050 Q28G58_XENTR protein 1 (Silurana tropicalis) 367 100.00% Xenopus tropicalis (Western clawed frog) ARP48239_P050 A4IJ12_XENTR Putative uncharacterized protein (Silurana tropicalis) 107 100.00% Developmentally‐regulated GTP‐binding ARP48239_P050 DRG1_XENLA protein 1 (DRG‐1) (xDRG) Xenopus laevis (African clawed frog) 367 100.00% Hypoxia‐inducible factor 1, alpha subunit Xenopus tropicalis (Western clawed frog) ARP39317_P050 Q6P7M1_XENTR inhibitor (Silurana tropicalis) 352 100.00% ARP39317_P050 Q6IR51_XENLA MGC84481 protein Xenopus laevis (African clawed frog) 352 100.00% Xenopus tropicalis (Western clawed frog) ndel1a ARP47932_P050 Q0VFU4_XENTR Putative uncharacterized protein (Silurana tropicalis) 320 92.00% ndel1a ARP47932_P050 NDL1B_XENLA Nuclear distribution protein nudE‐like 1‐B Xenopus laevis (African clawed frog) 344 92.00% ndel1a ARP47932_P050 NDL1A_XENLA Nuclear distribution protein nudE‐like 1‐A Xenopus laevis (African clawed frog) 345 92.00% Xenopus tropicalis (Western clawed frog) ndel1a ARP47932_P050 NDEL1_XENTR Nuclear distribution protein nudE‐like 1 (Silurana tropicalis) 346 92.00% Xenopus tropicalis (Western clawed frog) ndel1a ARP47932_P050 NDE1_XENTR Nuclear distribution protein nudE homolog 1 (Silurana tropicalis) 349 92.00% Nuclear distribution protein nudE homolog 1‐ ndel1a ARP47932_P050 NDE1B_XENLA B Xenopus laevis (African clawed frog) 349 92.00%

Nuclear distribution protein nudE homolog 1‐ ndel1a ARP47932_P050 NDE1A_XENLA A (Mitotic phosphoprotein 43) (MP43) Xenopus laevis (African clawed frog) 349 92.00% Xenopus tropicalis (Western clawed frog) RBPMS2 ARP41199_P050 A9UME4_XENTR LOC100135328 protein (Silurana tropicalis) 199 92.00% RBPMS2 ARP41199_P050 Q66IX3_XENLA MGC84222 protein Xenopus laevis (African clawed frog) 197 85.00% RNA‐binding protein with multiple splicing (RBP‐MS) (Heart and RRM expressed RBPMS2 ARP41199_P050 RBPMS_XENLA sequence) (Hermes) Xenopus laevis (African clawed frog) 196 85.00% GF25109 ARP48088_P050 PAX8_XENLA Isoform 2 Xenopus laevis (African clawed frog) 403 92.00% Xenopus tropicalis (Western clawed frog) GF25109 ARP48088_P050 PAX8_XENTR Paired box protein Pax‐8 (Fragment) (Silurana tropicalis) 458 92.00% GF25109 ARP48088_P050 PAX8_XENLA Paired box protein Pax‐8 (XPax‐8) Xenopus laevis (African clawed frog) 465 92.00% Xenopus tropicalis (Western clawed frog) fam134b ARP44827_T100 B1H327_XENTR LOC100145538 protein (Silurana tropicalis) 351 92.00% ebf3 ARP31614_P050 B7ZRR5_XENLA Xebf‐3 protein Xenopus laevis (African clawed frog) 597 100.00% Xenopus tropicalis (Western clawed frog) ebf3 ARP31614_P050 A9ULR8_XENTR LOC100135240 protein (Fragment) (Silurana tropicalis) 496 100.00% ebf3 ARP31614_P050 COE2B_XENLA Isoform 2 Xenopus laevis (African clawed frog) 572 100.00% Transcription factor COE3 (xCOE3) (Olf‐1/EBF‐ ebf3 ARP31614_P050 COE3_XENLA like 2) (OE‐2) (xEBF‐3) (xOE‐2) Xenopus laevis (African clawed frog) 598 100.00% Transcription factor coe2 (Early B‐cell factor 2) Xenopus tropicalis (Western clawed frog) ebf3 ARP31614_P050 COE2_XENTR (EBF‐2) (Silurana tropicalis) 575 100.00%

Transcription factor coe2‐B (Xcoe2) (Early B‐ ebf3 ARP31614_P050 COE2B_XENLA cell factor 2‐B) (EBF‐2‐B) (Xebf‐2‐B) Xenopus laevis (African clawed frog) 580 100.00%

Transcription factor coe2‐A (Xcoe‐2) (Xcoe2) ebf3 ARP31614_P050 COE2A_XENLA (Early B‐cell factor 2‐A) (EBF‐2‐A) (Xebf‐2‐A) Xenopus laevis (African clawed frog) 575 100.00% MGC83056 ARP37166_T100 Q6AZP0_XENLA MGC83056 protein Xenopus laevis (African clawed frog) 672 100.00% DKFZp470E0911 ARP35743_P050 Q9PUN0_XENLA Metastasis associated 1‐like protein Xenopus laevis (African clawed frog) 670 100.00% DKFZp470E0911 ARP35743_P050 Q4V7T0_XENLA Mta2 protein Xenopus laevis (African clawed frog) 669 100.00% BRUNOL4 ARP40940_P050 B5LEQ5_XENLA RNA binding protein Bruno‐like 4 Xenopus laevis (African clawed frog) 471 100.00%

CUGBP Elav‐like family member 4 (CELF‐4) (Bruno‐like protein 4) (CUG‐BP‐ and ETR‐3‐like Xenopus tropicalis (Western clawed frog) BRUNOL4 ARP40940_P050 CELF4_XENTR factor 4) (RNA‐binding protein BRUNOL‐4) (Silurana tropicalis) 424 100.00% FBXO32 ARP43118_T100 Q6INF2_XENLA MGC83150 protein Xenopus laevis (African clawed frog) 351 92.00% Xenopus tropicalis (Western clawed frog) FBXO32 ARP43118_T100 Q569D4_XENTR Fbxo32 protein (Silurana tropicalis) 353 92.00% LHX5 ARP33267_P050 Q63ZR3_XENLA Putative uncharacterized protein Xenopus laevis (African clawed frog) 402 92.00% Xenopus tropicalis (Western clawed frog) LHX5 ARP33267_P050 Q28F23_XENTR LIM homeobox 5 (Silurana tropicalis) 402 92.00% LIM/homeobox protein Lhx5 (LIM homeobox protein 5) (Homeobox protein LIM‐5) (xLIM‐5) LHX5 ARP33267_P050 LHX5_XENLA (xLIM‐2A) Xenopus laevis (African clawed frog) 402 92.00% ap1b1 ARP53576_P050 Q7ZYG7_XENLA Ap2b1‐prov protein Xenopus laevis (African clawed frog) 951 100.00% Adaptor‐related protein complex 2, beta 1 Xenopus tropicalis (Western clawed frog) ap1b1 ARP53576_P050 Q6P4L7_XENTR subunit (Silurana tropicalis) 951 100.00% Xenopus tropicalis (Western clawed frog) ap1b1 ARP53576_P050 B2GUA2_XENTR LOC100158536 protein (Silurana tropicalis) 946 100.00% ap1b1 ARP53576_P050 A1L2H5_XENLA LOC100036849 protein Xenopus laevis (African clawed frog) 946 100.00%

ORF Names:v1g210739OrganismNematostel la vectensis (Starlet sea anemone) ARP50534_P050 C1D_XENLA Nuclear nucleic acid‐binding protein C1D Xenopus laevis (African clawed frog) 145 85.00% KIF13B ARP33926_P050 B9UR70_XENLA Kinesin 13B Xenopus laevis (African clawed frog) 1937 84.00%

Proteasome (Prosome macropain) subunit alpha type 6 (Proteasome (Prosome, Xenopus tropicalis (Western clawed frog) ARP40419_P050 Q6P7Z3_XENTR macropain) subunit, alpha type 6) (Silurana tropicalis) 246 85.00% 20S proteasome alpha1 subunit (Psma6‐prov ARP40419_P050 Q6AZR7_XENLA protein) Xenopus laevis (African clawed frog) 246 85.00% ARP40419_P050 Q5XGL4_XENLA LOC495277 protein Xenopus laevis (African clawed frog) 246 85.00% SMAD1 ARP38693_T100 Q98TU1_XENLA Smad protein Xenopus laevis (African clawed frog) 466 100.00% SMAD1 ARP38693_T100 Q91913_XENLA Mad1 protein Xenopus laevis (African clawed frog) 464 100.00% SMAD1 ARP38693_T100 Q91693_XENLA Mothers against DPP Xenopus laevis (African clawed frog) 464 100.00% SMAD1 ARP38693_T100 Q8QGG6_XENLA Smad8A Xenopus laevis (African clawed frog) 466 100.00% SMAD1 ARP38693_T100 Q8QGG5_XENLA Smad8B Xenopus laevis (African clawed frog) 468 100.00% SMAD1 ARP38693_T100 Q8QGG4_XENLA Smad8C Xenopus laevis (African clawed frog) 466 100.00% SMAD1 ARP38693_T100 Q6PF37_XENLA MGC69016 protein Xenopus laevis (African clawed frog) 465 100.00% SMAD1 ARP38693_T100 Q6PF32_XENLA Xmad protein Xenopus laevis (African clawed frog) 464 100.00% Xenopus tropicalis (Western clawed frog) SMAD1 ARP38693_T100 Q6DIZ6_XENTR SMAD family member 9 (Silurana tropicalis) 466 100.00% Xenopus tropicalis (Western clawed frog) SMAD1 ARP38693_T100 Q6DIS7_XENTR SMAD family member 1 (Silurana tropicalis) 464 100.00% SMAD1 ARP38693_T100 Q5HZ76_XENLA MADH1 protein Xenopus laevis (African clawed frog) 464 100.00% SMAD1 ARP38693_T100 P79947_XENLA Smad1.1 Xenopus laevis (African clawed frog) 467 100.00% Xenopus tropicalis (Western clawed frog) CREB1 ARP39811_P050 Q6NVP9_XENTR cAMP responsive element binding protein 1 (Silurana tropicalis) 327 100.00% CREB1 ARP39811_P050 Q8AVY5_XENLA Creb1‐prov protein Xenopus laevis (African clawed frog) 324 92.00% Xenopus tropicalis (Western clawed frog) ARP31459_T100 Q6PBG0_XENTR Putative uncharacterized protein MGC75686 (Silurana tropicalis) 180 84.00% ARP31459_T100 Q3KQD2_XENLA Putative uncharacterized protein Xenopus laevis (African clawed frog) 180 84.00% Ordered Locus Names:KPN78578_16540ORF Names:KPN_01684 EMBL ABR77115.1OrganismKlebsiella Survival of motor neuron‐related‐splicing pneumoniae subsp. pneumoniae (strain factor 30 (Survival motor neuron domain‐ Xenopus tropicalis (Western clawed frog) ATCC 700721 / MGH 78578) ARP40611_P050 SPF30_XENTR containing protein 1) (Silurana tropicalis) 238 100.00%

ORF Names:GSOID_T00012075001 EMBL CBY15182.1OrganismOikopleura Xenopus tropicalis (Western clawed frog) dioica (Tunicate) AVARP13015_P050 A9JRM3_XENTR LOC100135106 protein (Silurana tropicalis) 734 92.00% SLC25A29 ARP43788_T100 Q66KI7_XENLA Slc25a29 protein Xenopus laevis (African clawed frog) 246 92.00% Xenopus tropicalis (Western clawed frog) SLC25A29 ARP43788_T100 A4IIW2_XENTR Slc25a29 protein (Silurana tropicalis) 301 92.00%

Ordered Locus Names:SBI_00068OrganismStreptomyc Xenopus tropicalis (Western clawed frog) es bingchenggensis (strain BCW‐1) ARP36694_P050 Q0V9Q6_XENTR Minichromosome maintenance protein 8 (Silurana tropicalis) 843 78.00% Ordered Locus Names:SBI_00068OrganismStreptomyc Xenopus tropicalis (Western clawed frog) es bingchenggensis (strain BCW‐1) ARP36694_P050 A4IIB8_XENTR MGC146393 protein (Silurana tropicalis) 675 78.00%

Ordered Locus Names:SBI_00068OrganismStreptomyc es bingchenggensis (strain BCW‐1) ARP36694_P050 Q5F310_XENLA DNA‐dependent DNA helicase and ATPase Xenopus laevis (African clawed frog) 834 83.00%

Ordered Locus Names:SBI_00068OrganismStreptomyc es bingchenggensis (strain BCW‐1) ARP36694_P050 Q501Q5_XENLA MGC99291 protein Xenopus laevis (African clawed frog) 831 83.00% ORF Names:PANDA_001940 EMBL EFB28563.1OrganismAiluropoda melanoleuca (Giant panda) ARP33103_P050 Q6NRM9_XENLA MGC83489 protein Xenopus laevis (African clawed frog) 531 100.00% ORF Names:PANDA_001940 EMBL EFB28563.1OrganismAiluropoda melanoleuca (Giant panda) ARP33103_P050 Q6GM03_XENLA MGC84081 protein Xenopus laevis (African clawed frog) 511 100.00% ARP56075_P050 Q642N7_XENLA LOC446968 protein (Fragment) Xenopus laevis (African clawed frog) 545 100.00% Mink protein (Misshapen/Nck interacting tnikl ARP49031_P050 Q6DDZ8_XENLA Kinase) Xenopus laevis (African clawed frog) 1270 100.00% tnikl ARP49031_P050 Q32NV8_XENLA LOC443633 protein Xenopus laevis (African clawed frog) 485 92.00% Xenopus tropicalis (Western clawed frog) slitrk1 ARP50218_P050 A4IIG5_XENTR LOC100124997 protein (Silurana tropicalis) 696 92.00% Xenopus tropicalis (Western clawed frog) rplO ARP46191_P050 B0JYX8_XENTR LOC100145126 protein (Silurana tropicalis) 296 100.00% 39S ribosomal protein L15, mitochondrial rplO ARP46191_P050 RM15_XENLA (L15mt) (MRP‐L15) Xenopus laevis (African clawed frog) 296 100.00% Xenopus tropicalis (Western clawed frog) rims1 ARP34736_T100 Q0D2E0_XENTR Regulating synaptic membrane exocytosis 3 (Silurana tropicalis) 308 92.00% Xenopus tropicalis (Western clawed frog) rims1 ARP34736_T100 A7MC36_XENTR Putative uncharacterized protein (Silurana tropicalis) 284 84.00% Xenopus tropicalis (Western clawed frog) rims1 ARP34736_T100 A4IHZ8_XENTR Rims1 protein (Silurana tropicalis) 1518 84.00% AVARP13108_P050 Q68F22_XENLA LOC100101272 protein Xenopus laevis (African clawed frog) 595 100.00% Xenopus tropicalis (Western clawed frog) AVARP13108_P050 Q0D2D4_XENTR Syntaxin binding protein 1 (Silurana tropicalis) 604 100.00% LOC100037084 ARP40205_T100 A2BDA6_XENLA LOC100037084 protein Xenopus laevis (African clawed frog) 423 93.00% Triobp ARP34718_P050 Q6DDJ6_XENLA MGC83528 protein Xenopus laevis (African clawed frog) 543 84.00% Xenopus tropicalis (Western clawed frog) Triobp ARP34718_P050 Q3SYP0_XENTR Triobp protein (Fragment) (Silurana tropicalis) 542 84.00% Xenopus tropicalis (Western clawed frog) Triobp ARP34718_P050 B1H1A9_XENTR Triobp protein (Silurana tropicalis) 544 84.00% exoc4 ARP56253_P050 Q6INJ7_XENLA LOC432278 protein (Fragment) Xenopus laevis (African clawed frog) 338 92.00% exoc4 ARP56253_P050 Q52KN6_XENLA LOC779032 protein (Fragment) Xenopus laevis (African clawed frog) 991 92.00% Amidophosphoribosyltransferase (ATase) (EC 2.4.2.14) (Glutamine phosphoribosylpyrophosphate Xenopus tropicalis (Western clawed frog) PPAT ARP46079_P050 Q6P2Z4_XENTR amidotransferase) (Silurana tropicalis) 508 85.00% Amidophosphoribosyltransferase (ATase) (EC 2.4.2.14) (Glutamine phosphoribosylpyrophosphate PPAT ARP46079_P050 Q6PA71_XENLA amidotransferase) Xenopus laevis (African clawed frog) 508 78.00% Ionotropic glutamate receptor subunit GRIA2 AVARP13038_T100 B9V8R8_XENLA GluR2(R)flop Xenopus laevis (African clawed frog) 882 100.00% Xenopus tropicalis (Western clawed frog) GRIA2 AVARP13038_T100 B4F6U0_XENTR Putative uncharacterized protein (Silurana tropicalis) 767 100.00% Gabra2 AVARP13026_T100 Q6AX36_XENLA MGC86282 protein Xenopus laevis (African clawed frog) 451 80.00% Gamma‐aminobutyric acid A receptor subunit Gabra2 AVARP13026_T100 E5LEX5_XENLA alpha‐2 (Fragment) Xenopus laevis (African clawed frog) 380 80.00% LOC100135200 protein (Putative Xenopus tropicalis (Western clawed frog) LOC100135200 ARP55213_P050 A9ULG2_XENTR uncharacterized protein LOC100135200) (Silurana tropicalis) 425 100.00%

LOC100135200 ARP55213_P050 CV009_XENLA Uncharacterized protein C22orf9 homolog Xenopus laevis (African clawed frog) 399 100.00% Xenopus tropicalis (Western clawed frog) ARP56108_P050 LIS1_XENTR Lissencephaly‐1 homolog (Silurana tropicalis) 410 92.00% ARP56108_P050 LIS1_XENLA Lissencephaly‐1 homolog Xenopus laevis (African clawed frog) 410 92.00% Zbtb46 ARP50690_P050 Q6DCD9_XENLA Btbd4‐prov protein Xenopus laevis (African clawed frog) 576 84.00% Xenopus tropicalis (Western clawed frog) ZNF33A ARP35898_P050 Q0V9I0_XENTR Putative uncharacterized protein MGC146992 (Silurana tropicalis) 517 85.00% Xenopus tropicalis (Western clawed frog) ZNF33A ARP35898_P050 Q0V9Z4_XENTR Putative uncharacterized protein MGC145688 (Silurana tropicalis) 594 78.00% ZNF33A ARP35898_P050 B1H1R1_XENLA LOC100158283 protein Xenopus laevis (African clawed frog) 602 78.00% ZNF33A ARP35898_P050 Q5PPT5_XENLA LOC496085 protein (Fragment) Xenopus laevis (African clawed frog) 244 75.00% ZNF33A ARP35898_P050 Q3KPQ4_XENLA LOC496085 protein Xenopus laevis (African clawed frog) 270 75.00% Xenopus tropicalis (Western clawed frog) isl2 ARP39867_P050 C8CMG0_XENTR Islet 2 (Silurana tropicalis) 333 100.00% isl2 ARP39867_P050 Q08B34_XENLA Islet‐1 (LOC100126604 protein) Xenopus laevis (African clawed frog) 354 92.00% Dlx5 ARP38586_T100 Q6GLJ3_XENLA Dlx5 protein Xenopus laevis (African clawed frog) 286 84.00% Dlx5 ARP38586_T100 DLL3_XENLA Homeobox protein DLL‐3 (XDLL‐3) Xenopus laevis (African clawed frog) 289 84.00% DLL3 (Distal‐less homeo box 5) (Distal‐less Xenopus tropicalis (Western clawed frog) Dlx5 ARP38586_T100 Q6GLH9_XENTR homeobox 5) (Silurana tropicalis) 289 100.00% Kelch‐like 8 (Putative uncharacterized protein Xenopus tropicalis (Western clawed frog) Klhl8 ARP39442_P050 Q28D69_XENTR LOC550043) (Silurana tropicalis) 616 84.00% Xenopus tropicalis (Western clawed frog) THEX1 ARP41157_P050 Q28FF6_XENTR Exonuclease 1 (Silurana tropicalis) 345 92.00% Xenopus tropicalis (Western clawed frog) THEX1 ARP41157_P050 A9JSA4_XENTR Putative uncharacterized protein LOC548900 (Silurana tropicalis) 345 92.00% THEX1 ARP41157_P050 Q4QQX7_XENLA Thex1 protein Xenopus laevis (African clawed frog) 348 84.00% Xenopus tropicalis (Western clawed frog) ARP33347_P050 ING3_XENTR Inhibitor of growth protein 3 (Silurana tropicalis) 417 100.00% ARP33347_P050 ING3_XENLA Inhibitor of growth protein 3 Xenopus laevis (African clawed frog) 416 100.00% Activin RECEPTOR=CLONE XSTK8 (Acvr2b ARP45043_P050 Q9PSL9_XENLA protein) Xenopus laevis (African clawed frog) 510 100.00% Activin RECEPTOR=CLONE XSTK3 (XSTK2 ARP45043_P050 Q9PSL8_XENLA protein) Xenopus laevis (African clawed frog) 510 100.00% ARP45043_P050 Q91962_9PIPI Activin receptor Xenopus 510 100.00% Activin A receptor, type IIB (Activin receptor Xenopus tropicalis (Western clawed frog) ARP45043_P050 Q6DEV8_XENTR IIB) (Silurana tropicalis) 510 100.00% Activin receptor type‐2B (EC 2.7.11.30) ARP45043_P050 AVR2B_XENLA (Activin receptor type IIB) (ACTR‐IIB) Xenopus laevis (African clawed frog) 511 100.00% Activin RECEPTOR=CLONE XSTK9 (LOC495087 ARP45043_P050 Q9PSM0_XENLA protein) Xenopus laevis (African clawed frog) 512 85.00% Xenopus tropicalis (Western clawed frog) ARP45043_P050 B5DDW8_XENTR Putative uncharacterized protein (Silurana tropicalis) 513 85.00% Activin receptor type‐2A (EC 2.7.11.30) ARP45043_P050 AVR2A_XENLA (Activin receptor type IIA) (ACTR‐IIA) Xenopus laevis (African clawed frog) 514 85.00% Novel proteinn (Ortholog of human cytokine induced protein 29 kDa CIP29) (RIKEN cDNA Xenopus tropicalis (Western clawed frog) sarnp ARP50729_P050 Q28HK0_XENTR 1110005A23 gene) (Silurana tropicalis) 207 92.00% sarnp ARP50729_P050 A3KND3_XENLA LOC100049111 protein Xenopus laevis (African clawed frog) 208 84.00% sarnp ARP50729_P050 Q5U541_XENLA LOC495376 protein Xenopus laevis (African clawed frog) 208 83.00%

ORF Names:v1g199033OrganismNematostel la vectensis (Starlet sea anemone) ARP43158_T100 Q7ZXW4_XENLA Nmp200‐prov protein Xenopus laevis (African clawed frog) 504 92.00%

ORF Names:v1g199033OrganismNematostel Xenopus tropicalis (Western clawed frog) la vectensis (Starlet sea anemone) ARP43158_T100 Q6GLG2_XENTR PRP19/PSO4 homolog (S. cerevisiae) (Silurana tropicalis) 439 92.00%

ORF Names:v1g199033OrganismNematostel PRP19/PSO4 pre‐mRNA processing factor 19 Xenopus tropicalis (Western clawed frog) la vectensis (Starlet sea anemone) ARP43158_T100 Q28E36_XENTR homolog (S. cerevisiae) (Silurana tropicalis) 504 92.00% ORF Names:OsI_03315 EMBL EAY75412.1OrganismOryza sativa subsp. indica (Rice) ARP40624_P050 Q9W7I1_XENLA Activated protein kinase C receptor Xenopus laevis (African clawed frog) 317 100.00% ORF Names:OsI_03315 EMBL EAY75412.1OrganismOryza sativa subsp. indica (Rice) ARP40624_P050 Q8AVP6_XENLA Gnb2l1‐prov protein (LOC446289 protein) Xenopus laevis (African clawed frog) 317 100.00% Guanine nucleotide binding protein (G ORF Names:OsI_03315 EMBL protein), beta polypeptide (Guanine EAY75412.1OrganismOryza sativa nucleotide binding protein (G protein), beta Xenopus tropicalis (Western clawed frog) subsp. indica (Rice) ARP40624_P050 Q6DIV0_XENTR polypeptide 2‐like 1) (Silurana tropicalis) 317 100.00% ORF Names:OsI_03315 EMBL EAY75412.1OrganismOryza sativa subsp. indica (Rice) ARP40624_P050 Q5U275_XENLA LOC495666 protein Xenopus laevis (African clawed frog) 317 100.00% Ube2l6 ARP43033_P050 Q6AZI4_XENLA LOC446231 protein (Fragment) Xenopus laevis (African clawed frog) 153 84.00% Xenopus tropicalis (Western clawed frog) Ube2l6 ARP43033_P050 Q5BJ50_XENTR Ubiquitin‐conjugating enzyme E2L 3 (Silurana tropicalis) 154 84.00% Ube2l6 ARP43033_P050 Q4QR35_XENLA LOC446231 protein Xenopus laevis (African clawed frog) 154 84.00%

Ube2l6 ARP43033_P050 Q6DFK8_XENLA LOC495381 protein (Ube2d2‐prov protein) Xenopus laevis (African clawed frog) 147 76.00% Xenopus tropicalis (Western clawed frog) Ube2l6 ARP43033_P050 B0JYU2_XENTR Putative uncharacterized protein (Fragment) (Silurana tropicalis) 136 76.00% Ubiquitin‐conjugating enzyme E2D 1 (UBC4/5 Xenopus tropicalis (Western clawed frog) Ube2l6 ARP43033_P050 A0JM78_XENTR homolog) (Silurana tropicalis) 147 76.00% Ubiquitin‐conjugating enzyme E2 D4 (EC 6.3.2.19) (Ubiquitin carrier protein D4) Ube2l6 ARP43033_P050 UB2D4_XENLA (Ubiquitin‐protein ligase D4) Xenopus laevis (African clawed frog) 147 76.00% Ube2l6 ARP43033_P050 Q7SZ88_XENLA Ube2n‐prov protein Xenopus laevis (African clawed frog) 152 100.00% Ubiquitin‐conjugating enzyme E2N (UBC13 homolog) (Ubiquitin‐conjugating enzyme E2N Xenopus tropicalis (Western clawed frog) Ube2l6 ARP43033_P050 Q6P349_XENTR (UBC13 homolog, yeast)) (Silurana tropicalis) 152 100.00% NRF1 ARP34523_P050 Q6DDH1_XENLA MGC83958 protein Xenopus laevis (African clawed frog) 523 100.00% SNRPN ARP40443_P050 Q8AVT2_XENLA Snrpn‐prov protein Xenopus laevis (African clawed frog) 236 100.00% Xenopus tropicalis (Western clawed frog) SNRPN ARP40443_P050 Q6NX14_XENTR SNRPN upstream reading frame (Silurana tropicalis) 237 100.00% SNRPN ARP40443_P050 Q2VPN2_XENLA MGC130840 protein Xenopus laevis (African clawed frog) 234 100.00% SNRPN ARP40443_P050 Q0IHK1_XENLA Snrpn protein Xenopus laevis (African clawed frog) 236 100.00% DKEY‐3B8.1 ARP51934_P050 Q6NU87_XENLA MGC81145 protein Xenopus laevis (African clawed frog) 246 84.00% DKEY‐3B8.1 ARP51934_P050 Q3KPK1_XENLA MGC132396 protein Xenopus laevis (African clawed frog) 246 84.00% RPLP0 ARP40221_P050 Q8AVI3_XENLA Arbp‐prov protein Xenopus laevis (African clawed frog) 315 100.00% Xenopus tropicalis (Western clawed frog) RPLP0 ARP40221_P050 Q6P8D0_XENTR Acidic ribosomal phosphoprotein P0 (Silurana tropicalis) 314 100.00%

ORF Names:TRIADDRAFT_25137 EMBL EDV24473.1OrganismTrichoplax Xenopus tropicalis (Western clawed frog) adhaerens (Trichoplax reptans) P100607_P050 FOXO1_XENTR Forkhead box protein O1 (FoxO1) (FoxO1A) (Silurana tropicalis) 626 78.00% ORF Names:TRIADDRAFT_25137 EMBL EDV24473.1OrganismTrichoplax Forkhead box protein O1 (FoxO1) (xFoxO1) adhaerens (Trichoplax reptans) P100607_P050 FOXO1_XENLA (FoxO1A) Xenopus laevis (African clawed frog) 631 78.00%

ORF Names:TRIADDRAFT_25137 EMBL EDV24473.1OrganismTrichoplax adhaerens (Trichoplax reptans) P100607_P050 C1KC09_XENLA Forkhead box O4 Xenopus laevis (African clawed frog) 485 90.00% GSTM3 ARP53562_P050 Q90WM9_XENLA Glutathione S‐transferase (EC 2.5.1.18) Xenopus laevis (African clawed frog) 219 75.00% GSTM3 ARP53562_P050 Q7SZ23_XENLA Gstm2‐prov protein Xenopus laevis (African clawed frog) 219 75.00% Nova1 ARP40397_P050 Q6GM36_XENLA MGC84002 protein Xenopus laevis (African clawed frog) 484 100.00% Xenopus tropicalis (Western clawed frog) Nova1 ARP40397_P050 A4II03_XENTR LOC100124925 protein (Silurana tropicalis) 508 100.00% Nova1 ARP40397_P050 Q6GPZ4_XENLA Nova1 protein Xenopus laevis (African clawed frog) 413 84.00% Nova1 ARP40397_P050 Q7ZWS0_XENLA MGC53786 protein Xenopus laevis (African clawed frog) 315 84.00% Xenopus tropicalis (Western clawed frog) Nova1 ARP40397_P050 Q566K8_XENTR Neuro‐oncological ventral antigen 2 (Silurana tropicalis) 413 76.00% ORF Names:GSPATT00027717001 EMBL CAK56687.1OrganismParamecium tetraurelia ARP44361_T100 Q6PCH9_XENLA Npr protein Xenopus laevis (African clawed frog) 680 100.00% ORF Names:GSPATT00027717001 EMBL CAK56687.1OrganismParamecium tetraurelia ARP44361_T100 A4PID6_XENLA NADPH‐P450 reductase Xenopus laevis (African clawed frog) 680 100.00%

ORF Names:v1g243769OrganismNematostel Cleavage and polyadenylation specific factor Xenopus tropicalis (Western clawed frog) la vectensis (Starlet sea anemone) ARP40840_T100 Q6DIH6_XENTR 3, 73kDa (Silurana tropicalis) 692 100.00%

ORF Names:v1g243769OrganismNematostel la vectensis (Starlet sea anemone) ARP40840_T100 Q5XGZ1_XENLA LOC495111 protein Xenopus laevis (African clawed frog) 692 100.00%

ORF Names:v1g243769OrganismNematostel Xenopus tropicalis (Western clawed frog) la vectensis (Starlet sea anemone) ARP40840_T100 Q28FT5_XENTR Cleavage and polyadenylation specific factor 3 (Silurana tropicalis) 692 100.00%

ORF Names:An08g07420 EMBL CAK39989.1OrganismAspergillus niger Carbamoyl‐phosphate synthetase I (EC (strain CBS 513.88 / FGSC A1513) ARP45690_T100 Q3S2E9_XENLA 6.3.4.16) Xenopus laevis (African clawed frog) 1494 78.00% ORF Names:An08g07420 EMBL CAK39989.1OrganismAspergillus niger Xenopus tropicalis (Western clawed frog) (strain CBS 513.88 / FGSC A1513) ARP45690_T100 B2GU38_XENTR LOC100158506 protein (Fragment) (Silurana tropicalis) 1492 78.00%

ORF Names:BRAFLDRAFT_89899 EMBL EEN66079.1OrganismBranchiostoma floridae (Florida lancelet) (Amphioxus) ARP36668_P050 Q5F310_XENLA DNA‐dependent DNA helicase and ATPase Xenopus laevis (African clawed frog) 834 78.00%

ORF Names:BRAFLDRAFT_89899 EMBL EEN66079.1OrganismBranchiostoma floridae (Florida lancelet) (Amphioxus) ARP36668_P050 Q501Q5_XENLA MGC99291 protein Xenopus laevis (African clawed frog) 831 78.00%

ORF Names:BRAFLDRAFT_89899 EMBL EEN66079.1OrganismBranchiostoma Xenopus tropicalis (Western clawed frog) floridae (Florida lancelet) (Amphioxus) ARP36668_P050 Q0V9Q6_XENTR Minichromosome maintenance protein 8 (Silurana tropicalis) 843 78.00% ARP38542_P050 Q6DDH1_XENLA MGC83958 protein Xenopus laevis (African clawed frog) 523 85.00% Homeobox protein Nkx‐3.2 (Bagpipe ARP33200_P050 NKX32_XENLA homeobox protein homolog 1) (Xbap) Xenopus laevis (African clawed frog) 329 100.00% ARP33200_P050 ZAX_XENLA Homeobox protein zampogna (Xzax) Xenopus laevis (African clawed frog) 224 85.00% ARP33536_T100 Q6INX6_XENLA MGC80065 protein Xenopus laevis (African clawed frog) 106 100.00% Xenopus tropicalis (Western clawed frog) ARP33536_T100 Q5XGA8_XENTR Ribosomal protein S16 (Silurana tropicalis) 146 100.00% ARP33536_T100 Q3KQC9_XENLA Rps16 protein Xenopus laevis (African clawed frog) 146 100.00% Xenopus tropicalis (Western clawed frog) 5‐Mar ARP43232_P050 B1H1A5_XENTR March5 protein (Silurana tropicalis) 283 100.00% E3 ubiquitin‐protein ligase MARCH5 (EC 6.3.2.‐ ) (Membrane‐associated RING finger protein 5) (Membrane‐associated RING‐CH protein V) 5‐Mar ARP43232_P050 MARH5_XENLA (MARCH‐V) Xenopus laevis (African clawed frog) 283 100.00% Kras ARP55408_P050 Q91832_XENLA LOC397771 protein (X.laevis ras protein) Xenopus laevis (African clawed frog) 186 100.00% Kras ARP55408_P050 Q8UUZ4_XENLA Small G‐protein H‐Ras Xenopus laevis (African clawed frog) 189 100.00% Kras2 protein (V‐Ki‐ras2 Kirsten rat sarcoma Xenopus tropicalis (Western clawed frog) Kras ARP55408_P050 Q66JH1_XENTR viral oncogene homolog) (Silurana tropicalis) 186 100.00% Kras ARP55408_P050 Q66JB2_XENLA Putative uncharacterized protein Xenopus laevis (African clawed frog) 187 100.00% Kras ARP55408_P050 Q5U5E1_XENLA Putative uncharacterized protein Xenopus laevis (African clawed frog) 187 100.00% V‐Ha‐ras Harvey rat sarcoma viral oncogene Xenopus tropicalis (Western clawed frog) Kras ARP55408_P050 Q28EW2_XENTR homolog (Silurana tropicalis) 189 100.00% Novel gene of the neuroblastoma RAS viral (V‐ ras) oncogene homolog family (Putative Xenopus tropicalis (Western clawed frog) Kras ARP55408_P050 Q28D17_XENTR uncharacterized protein LOC549517) (Silurana tropicalis) 189 100.00% Kras ARP55408_P050 O93563_XENLA Ras protein Xenopus laevis (African clawed frog) 188 100.00% Kras ARP55408_P050 O13021_XENLA Proto‐oncogene K‐Ras2A Xenopus laevis (African clawed frog) 189 100.00%

Kras ARP55408_P050 RASN_XENLA GTPase NRas (Transforming protein N‐Ras) Xenopus laevis (African clawed frog) 189 100.00% Kras ARP55408_P050 RASK_XENLA GTPase KRas (Ki‐Ras) (K‐ras) Xenopus laevis (African clawed frog) 187 100.00% Xenopus tropicalis (Western clawed frog) zfr ARP34527_P050 ZFR_XENTR Zinc finger RNA‐binding protein (Silurana tropicalis) 1065 92.00% zfr ARP34527_P050 ZFR_XENLA Zinc finger RNA‐binding protein Xenopus laevis (African clawed frog) 1054 92.00% Eukaryotic translation initiation factor 2 ORF Names:ACLA_041660 EMBL subunit 1 (Eukaryotic translation initiation EAW09945.1OrganismAspergillus factor 2 subunit alpha) (eIF‐2‐alpha) (eIF‐2A) Xenopus tropicalis (Western clawed frog) clavatus ARP40507_P050 IF2A_XENTR (eIF‐2alpha) (Silurana tropicalis) 315 92.00% Eukaryotic translation initiation factor 2 ORF Names:ACLA_041660 EMBL subunit 1 (Eukaryotic translation initiation EAW09945.1OrganismAspergillus factor 2 subunit alpha) (eIF‐2‐alpha) (eIF‐2A) clavatus ARP40507_P050 IF2A_XENLA (eIF‐2alpha) Xenopus laevis (African clawed frog) 315 92.00% ORF Names:TVAG_009320 EMBL EAX89912.1OrganismTrichomonas Xenopus tropicalis (Western clawed frog) vaginalis ARP34189_T100 Q5EB36_XENTR MGC97656 protein (Silurana tropicalis) 443 100.00% ORF Names:TVAG_009320 EMBL EAX89912.1OrganismTrichomonas vaginalis ARP34189_T100 Q2VPH6_XENLA LOC432342 protein Xenopus laevis (African clawed frog) 443 100.00% ORF Names:TVAG_009320 EMBL EAX89912.1OrganismTrichomonas COP9 signalosome complex subunit 2 vaginalis ARP34189_T100 CSN2_XENLA (Signalosome subunit 2) (Fragment) Xenopus laevis (African clawed frog) 441 100.00% ORF Names:PANDA_006503 EMBL EFB16179.1OrganismAiluropoda melanoleuca (Giant panda) ARP34463_T100 Q6GN57_XENLA LOC443681 protein (Fragment) Xenopus laevis (African clawed frog) 636 100.00% ORF Names:PANDA_006503 EMBL EFB16179.1OrganismAiluropoda melanoleuca (Giant panda) ARP34463_T100 Q2T9I7_XENLA LOC443681 protein Xenopus laevis (African clawed frog) 612 100.00% ORF Names:LELG_03010 EMBL EDK44831.1OrganismLodderomyces elongisporus (Yeast) (Saccharomyces elongisporus) ARP43461_P050 Q641C0_XENLA LOC446971 protein (Fragment) Xenopus laevis (African clawed frog) 448 76.00% ORF Names:LELG_03010 EMBL EDK44831.1OrganismLodderomyces elongisporus (Yeast) (Saccharomyces elongisporus) ARP43461_P050 Q505M6_XENLA LOC446971 protein (Fragment) Xenopus laevis (African clawed frog) 435 76.00% ORF Names:LELG_03010 EMBL EDK44831.1OrganismLodderomyces elongisporus (Yeast) (Saccharomyces elongisporus) ARP43461_P050 Q2TAW1_XENLA LOC446971 protein Xenopus laevis (African clawed frog) 459 76.00% Xenopus tropicalis (Western clawed frog) DKEYP‐75B4.3 ARP43490_P050 RN121_XENTR RING finger protein 121 (Silurana tropicalis) 327 92.00% DKEYP‐75B4.3 ARP43490_P050 RN121_XENLA RING finger protein 121 Xenopus laevis (African clawed frog) 327 92.00% DKEYP‐75B4.3 ARP43490_P050 Q6PF25_XENLA MGC69129 protein Xenopus laevis (African clawed frog) 327 85.00% frRunx1 P100877_P050 RUNX1_XENLA Isoform 2 Xenopus laevis (African clawed frog) 476 100.00%

Runt‐related transcription factor 1 (Acute myeloid leukemia 1 protein) (XAML) (Core‐ frRunx1 P100877_P050 RUNX1_XENLA binding factor subunit alpha‐2) (CBF‐alpha‐2) Xenopus laevis (African clawed frog) 462 100.00% frRunx1 P100877_P050 D5KZX4_XENLA Runt‐related transcription factor 3 Xenopus laevis (African clawed frog) 393 78.00% ORF Names:GSPATT00029554001 EMBL CAK58924.1OrganismParamecium MGC69114 protein (Transketolase) (EC tetraurelia ARP48958_T100 Q9I8J7_XENLA 2.2.1.1) Xenopus laevis (African clawed frog) 625 100.00% ORF Names:GSPATT00029554001 EMBL CAK58924.1OrganismParamecium Xenopus tropicalis (Western clawed frog) tetraurelia ARP48958_T100 Q6P4V9_XENTR Transketolase (Silurana tropicalis) 625 92.00% ORF Names:GSPATT00029554001 EMBL CAK58924.1OrganismParamecium tetraurelia ARP48958_T100 Q6PAD4_XENLA MGC68785 protein Xenopus laevis (African clawed frog) 627 92.00% ORF Names:GSPATT00029554001 EMBL CAK58924.1OrganismParamecium Xenopus tropicalis (Western clawed frog) tetraurelia ARP48958_T100 Q5EAL2_XENTR MGC107778 protein (Silurana tropicalis) 627 92.00% ORF Names:GSPATT00029554001 EMBL CAK58924.1OrganismParamecium tetraurelia ARP48958_T100 Q566F6_XENLA LOC780759 protein (Fragment) Xenopus laevis (African clawed frog) 656 92.00% ORF Names:GSPATT00029554001 EMBL CAK58924.1OrganismParamecium tetraurelia ARP48958_T100 O73616_XENLA Transketolase (Fragment) Xenopus laevis (African clawed frog) 126 92.00% ORF Names:GSPATT00029554001 EMBL CAK58924.1OrganismParamecium tetraurelia ARP48958_T100 A8WH37_XENLA LOC780759 protein (Fragment) Xenopus laevis (African clawed frog) 656 92.00% ORF Names:GSPATT00029554001 EMBL CAK58924.1OrganismParamecium tetraurelia ARP48958_T100 A0JMR2_XENLA LOC780759 protein (Fragment) Xenopus laevis (African clawed frog) 655 92.00% LOC100036883 ARP41733_P050 Q7ZY83_XENLA LOC398464 protein (Fragment) Xenopus laevis (African clawed frog) 469 84.00% LOC100036883 ARP41733_P050 Q7T0X6_XENLA MGC68905 protein Xenopus laevis (African clawed frog) 437 84.00% LOC100036883 ARP41733_P050 Q642P1_XENLA LOC446967 protein (Fragment) Xenopus laevis (African clawed frog) 467 84.00% LOC100036883 ARP41733_P050 Q4QR57_XENLA LOC398464 protein Xenopus laevis (African clawed frog) 454 84.00% LOC100036883 ARP41733_P050 Q2VPN9_XENLA MGC68905 protein Xenopus laevis (African clawed frog) 437 84.00% Xenopus tropicalis (Western clawed frog) LOC100036883 ARP41733_P050 B0BMI8_XENTR Krt12 protein (Silurana tropicalis) 450 84.00% Xenopus tropicalis (Western clawed frog) LOC100036883 ARP41733_P050 B0BMI0_XENTR LOC100145042 protein (Silurana tropicalis) 423 84.00% Xenopus tropicalis (Western clawed frog) LOC100036883 ARP41733_P050 B0BMH1_XENTR Krt12 protein (Silurana tropicalis) 450 84.00% LOC100036883 ARP41733_P050 K1C1_XENLA Keratin, type I cytoskeletal 47 kDa Xenopus laevis (African clawed frog) 429 84.00% LOC100036883 ARP41733_P050 A1L2L4_XENLA LOC100036883 protein Xenopus laevis (African clawed frog) 437 91.00% Xenopus tropicalis (Western clawed frog) RRBP1 ARP45020_P050 B3DL66_XENTR Ktn1 protein (Silurana tropicalis) 1375 92.00% RRBP1 ARP45020_P050 Q6PCJ8_XENLA MGC68897 protein Xenopus laevis (African clawed frog) 1055 78.00% RRBP1 ARP45020_P050 Q6GNE7_XENLA MGC82852 protein Xenopus laevis (African clawed frog) 1012 78.00% Ribosome binding protein 1 homolog 180kDa Xenopus tropicalis (Western clawed frog) RRBP1 ARP45020_P050 Q6GL13_XENTR () (Silurana tropicalis) 1037 78.00% ARP35278_P050 Q6GPE7_XENLA MGC80434 protein Xenopus laevis (African clawed frog) 552 85.00% Xenopus tropicalis (Western clawed frog) mcoln1 ARP35278_P050 Q28DB4_XENTR Mucolipin 3 (Silurana tropicalis) 553 85.00% Xenopus tropicalis (Western clawed frog) ARP30307_P050 Q6NTF1_XENTR Tumor protein p53 (Silurana tropicalis) 362 100.00%

ORF Names:v1g80696OrganismNematostell Xenopus tropicalis (Western clawed frog) a vectensis (Starlet sea anemone) P100953_P050 Q66IK5_XENTR Max protein (Silurana tropicalis) 127 100.00%

ORF Names:v1g80696OrganismNematostell a vectensis (Starlet sea anemone) P100953_P050 MAX_XENLA Isoform XMAX3 Xenopus laevis (African clawed frog) 154 100.00%

ORF Names:v1g80696OrganismNematostell a vectensis (Starlet sea anemone) P100953_P050 MAX_XENLA Isoform XMAX1 Xenopus laevis (African clawed frog) 127 100.00% Eukaryotic translation elongation factor 1 Xenopus tropicalis (Western clawed frog) ef1a ARP48166_T100 A9UMS0_XENTR alpha 1 (Silurana tropicalis) 462 100.00% ef1a ARP48166_T100 A1L3K0_XENLA LOC100037028 protein (Fragment) Xenopus laevis (African clawed frog) 470 100.00% Elongation factor 1‐alpha, oocyte form (EF‐1‐ ef1a ARP48166_T100 EF1A2_XENLA alpha‐O) (EF‐1AO) (42S p48) Xenopus laevis (African clawed frog) 461 100.00% Elongation factor 1‐alpha, somatic form (EF‐1‐ ef1a ARP48166_T100 EF1A0_XENLA alpha‐S) Xenopus laevis (African clawed frog) 462 100.00% ef1a ARP48166_T100 Q7ZXA2_XENLA Eef1a‐o1 protein Xenopus laevis (African clawed frog) 461 92.00% Eukaryotic translation elongation factor 1 alpha 1 (Eukaryotic translation elongation Xenopus tropicalis (Western clawed frog) ef1a ARP48166_T100 Q6P356_XENTR factor 1 alpha 1, oocyte form) (Silurana tropicalis) 461 92.00% Elongation factor 1‐alpha, oocyte form (EF‐1‐ ef1a ARP48166_T100 EF1A3_XENLA alpha‐O1) (EF‐1AO1) Xenopus laevis (African clawed frog) 461 92.00% ef1a ARP48166_T100 Q7SYT0_XENLA Eef1a2‐prov protein Xenopus laevis (African clawed frog) 463 92.00% Eukaryotic translation elongation factor 1 Xenopus tropicalis (Western clawed frog) ef1a ARP48166_T100 Q5I0S9_XENTR alpha 2 (Silurana tropicalis) 463 92.00% Xenopus tropicalis (Western clawed frog) ef1a ARP48166_T100 B1H2D7_XENTR LOC100145396 protein (Silurana tropicalis) 462 92.00% ef1a ARP48166_T100 Q640D9_XENLA LOC494720 protein Xenopus laevis (African clawed frog) 461 85.00% NR3C2 P100726_P050 Q66J29_XENLA Nr3c2 protein Xenopus laevis (African clawed frog) 979 92.00% Mineralocorticoid receptor (MR) (Nuclear receptor subfamily 3 group C member 2) NR3C2 P100726_P050 MCR_XENLA (Fragment) Xenopus laevis (African clawed frog) 612 92.00% Xenopus tropicalis (Western clawed frog) ARP45217_P050 A9JRM2_XENTR LOC100135105 protein (Silurana tropicalis) 533 78.00% ARP45217_P050 Q8AVH8_XENLA Gns‐prov protein Xenopus laevis (African clawed frog) 547 76.00% Potassium voltage‐gated channel KQT‐like Xenopus tropicalis (Western clawed frog) KCNQ3 ARP35459_T100 Q0P4Q9_XENTR protein 4 (Silurana tropicalis) 606 85.00% KCNQ3 ARP35459_T100 B1N659_XENLA KvLQT‐1 Xenopus laevis (African clawed frog) 652 78.00% Xenopus tropicalis (Western clawed frog) KCNQ3 ARP35459_T100 B1H1A7_XENTR LOC100145329 protein (Fragment) (Silurana tropicalis) 390 78.00%

Potassium voltage‐gated channel subfamily KQT member 1 (IKs producing slow voltage‐ gated potassium channel subunit alpha xKvLQT1) (KQT‐like 1) (Voltage‐gated KCNQ3 ARP35459_T100 KCNQ1_XENLA potassium channel subunit Kv7.1) (Fragment) Xenopus laevis (African clawed frog) 377 78.00% Xenopus tropicalis (Western clawed frog) kif5a ARP54737_P050 A4IIQ8_XENTR Kif5a protein (Silurana tropicalis) 1033 92.00% kif5a ARP54737_P050 A5XAW2_XENLA Kinesin heavy chain (Fragment) Xenopus laevis (African clawed frog) 962 76.00% Tmem127 ARP47363_P050 Q6DCF3_XENLA MGC83336 protein Xenopus laevis (African clawed frog) 237 100.00% Putative uncharacterized protein LOC549686 Xenopus tropicalis (Western clawed frog) Tmem127 ARP47363_P050 B3DLE5_XENTR (LOC549686 protein) (Silurana tropicalis) 237 100.00% 2‐acylglycerol O‐acyltransferase 2‐A (EC ORF Names:OSTLU_13176 EMBL 2.3.1.22) (Acyl‐CoA:monoacylglycerol ABO99368.1OrganismOstreococcus acyltransferase 2‐A) (MGAT2‐A) lucimarinus (strain CCE9901) ARP49925_P050 MOG2A_XENLA (Monoacylglycerol O‐acyltransferase 2‐A) Xenopus laevis (African clawed frog) 335 84.00% ARP35529_T100 B1N659_XENLA KvLQT‐1 Xenopus laevis (African clawed frog) 652 92.00% Xenopus tropicalis (Western clawed frog) ARP35529_T100 B1H1A7_XENTR LOC100145329 protein (Fragment) (Silurana tropicalis) 390 92.00%

Potassium voltage‐gated channel subfamily KQT member 1 (IKs producing slow voltage‐ gated potassium channel subunit alpha xKvLQT1) (KQT‐like 1) (Voltage‐gated ARP35529_T100 KCNQ1_XENLA potassium channel subunit Kv7.1) (Fragment) Xenopus laevis (African clawed frog) 377 92.00% ORF Names:MED121_10679 EMBL EAQ64822.1OrganismMarinomonas sp. Xenopus tropicalis (Western clawed frog) MED121 ARP46065_P050 Q6DJR0_XENTR Crystallin, zeta (Quinone reductase) (Silurana tropicalis) 329 85.00% ORF Names:MED121_10679 EMBL EAQ64822.1OrganismMarinomonas sp. MED121 ARP46065_P050 Q6DEC5_XENLA LOC445846 protein (Fragment) Xenopus laevis (African clawed frog) 335 78.00% ORF Names:MED121_10679 EMBL EAQ64822.1OrganismMarinomonas sp. MED121 ARP46065_P050 Q52L16_XENLA LOC445846 protein Xenopus laevis (African clawed frog) 329 78.00% si:ch211‐203b8.5 ARP50695_P050 Q2NLA6_XENLA MGC131238 protein Xenopus laevis (African clawed frog) 495 100.00% Xenopus tropicalis (Western clawed frog) si:ch211‐203b8.5 ARP50695_P050 CCNL2_XENTR Cyclin‐L2 (Silurana tropicalis) 497 100.00% si:ch211‐203b8.5 ARP50695_P050 Q32NA6_XENLA MGC132032 protein Xenopus laevis (African clawed frog) 495 84.00% Xenopus tropicalis (Western clawed frog) si:ch211‐203b8.5 ARP50695_P050 B0BMI4_XENTR Ccnl1 protein (Fragment) (Silurana tropicalis) 475 84.00% si:ch211‐203b8.5 ARP50695_P050 CCNL1_XENLA Cyclin‐L1 Xenopus laevis (African clawed frog) 496 84.00% ORF Names:GSPATT00005245001 EMBL CAK60496.1OrganismParamecium tetraurelia ARP51941_P050 Q6GN14_XENLA MGC83646 protein Xenopus laevis (African clawed frog) 412 100.00% ORF Names:GSPATT00005245001 EMBL CAK60496.1OrganismParamecium Xenopus tropicalis (Western clawed frog) tetraurelia ARP51941_P050 B4F6S2_XENTR Putative uncharacterized protein (Silurana tropicalis) 410 92.00% ORF Names:GSPATT00005245001 EMBL CAK60496.1OrganismParamecium Xenopus tropicalis (Western clawed frog) tetraurelia ARP51941_P050 Q6GL54_XENTR Casein kinase 1, gamma 1 (Silurana tropicalis) 451 85.00% ORF Names:GSPATT00005245001 EMBL CAK60496.1OrganismParamecium Xenopus tropicalis (Western clawed frog) tetraurelia ARP51941_P050 Q3LS18_XENTR Casein kinase 1 gamma 2 (Silurana tropicalis) 460 85.00% ORF Names:GSPATT00005245001 EMBL CAK60496.1OrganismParamecium Xenopus tropicalis (Western clawed frog) tetraurelia ARP51941_P050 B6ID06_XENTR Putative uncharacterized protein (Silurana tropicalis) 416 85.00% ORF Names:GSPATT00005245001 EMBL CAK60496.1OrganismParamecium tetraurelia ARP51941_P050 A1L1H1_XENLA LOC100036840 protein Xenopus laevis (African clawed frog) 424 85.00% ORF Names:GSPATT00005245001 EMBL CAK60496.1OrganismParamecium Casein kinase I isoform gamma‐1 (CKI‐gamma tetraurelia ARP51941_P050 KC1G1_XENLA 1) (EC 2.7.11.1) Xenopus laevis (African clawed frog) 460 85.00% ORF Names:GSPATT00005245001 EMBL CAK60496.1OrganismParamecium Xenopus tropicalis (Western clawed frog) tetraurelia ARP51941_P050 Q5FW24_XENTR Casein kinase 1, gamma 2 (Silurana tropicalis) 375 85.00% ORF Names:GSPATT00005245001 EMBL CAK60496.1OrganismParamecium tetraurelia ARP51941_P050 Q5EAV0_XENLA MGC85146 protein Xenopus laevis (African clawed frog) 424 85.00% Xenopus tropicalis (Western clawed frog) ARP51587_P050 Q5I079_XENTR Gastrulation brain homeobox 2, gene 2 (Silurana tropicalis) 340 92.00% ARP51587_P050 B7ZQL1_XENLA Homeobox protein Xgbx‐2 Xenopus laevis (African clawed frog) 340 92.00%

Homeobox protein GBX‐2 (Gastrulation and ARP51587_P050 GBX2_XENLA brain‐specific homeobox protein 2) (XGBX‐2) Xenopus laevis (African clawed frog) 340 92.00%

ARP51587_P050 Q90YY2_XENLA Gbx2b protein (Homeobox protein GBX‐2b) Xenopus laevis (African clawed frog) 336 85.00% ARP51587_P050 A6H8J9_XENLA Putative uncharacterized protein Xenopus laevis (African clawed frog) 340 85.00% Gale ARP54393_P050 Q7ZZM6_XENLA 1n569‐prov protein Xenopus laevis (African clawed frog) 348 90.00% Gale ARP54393_P050 Q6INX9_XENLA MGC80057 protein Xenopus laevis (African clawed frog) 348 90.00% Xenopus tropicalis (Western clawed frog) Gale ARP54393_P050 Q6DIJ2_XENTR Galactose‐4‐epimerase, UDP‐ (Silurana tropicalis) 348 90.00% Smarcd2 ARP33311_P050 Q7ZXG1_XENLA Smarcd1 protein (Fragment) Xenopus laevis (African clawed frog) 481 92.00% SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily Xenopus tropicalis (Western clawed frog) Smarcd2 ARP33311_P050 Q6GL18_XENTR d, member 1 (Silurana tropicalis) 508 92.00% Smarcd2 ARP33311_P050 Q6DCP7_XENLA Smarcd1 protein (Fragment) Xenopus laevis (African clawed frog) 513 92.00% Smarcd2 ARP33311_P050 Q66J25_XENLA Smarcd1 protein (Fragment) Xenopus laevis (African clawed frog) 504 92.00% Smarcd2 ARP33311_P050 Q505N3_XENLA Smarcd1 protein (Fragment) Xenopus laevis (African clawed frog) 496 92.00% SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily Xenopus tropicalis (Western clawed frog) Smarcd2 ARP33311_P050 Q28CT6_XENTR d, member 1 (Silurana tropicalis) 508 92.00% Smarcd2 ARP33311_P050 A1A5J8_XENLA Smarcd1 protein Xenopus laevis (African clawed frog) 507 92.00% Smarcd2 ARP33311_P050 Q52L33_XENLA MGC115001 protein Xenopus laevis (African clawed frog) 369 85.00% SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily Xenopus tropicalis (Western clawed frog) Smarcd2 ARP33311_P050 Q28BL9_XENTR d, member 2 (Silurana tropicalis) 480 85.00% Smarcd2 ARP33311_P050 Q66IP7_XENLA MGC86299 protein Xenopus laevis (African clawed frog) 465 85.00% RPL5 ARP56125_P050 Q8AVX2_XENLA Rpl5‐a protein Xenopus laevis (African clawed frog) 296 100.00% RPL5 ARP56125_P050 Q8AVI7_XENLA Rpl5‐b protein Xenopus laevis (African clawed frog) 296 100.00% Xenopus tropicalis (Western clawed frog) RPL5 ARP56125_P050 Q6PBE3_XENTR Ribosomal protein L5 (Silurana tropicalis) 296 100.00% RPL5 ARP56125_P050 RL5B_XENLA 60S ribosomal protein L5‐B Xenopus laevis (African clawed frog) 296 100.00% RPL5 ARP56125_P050 RL5A_XENLA 60S ribosomal protein L5‐A Xenopus laevis (African clawed frog) 296 100.00% RPL5 ARP56125_P050 A8E608_XENLA LOC100126642 protein Xenopus laevis (African clawed frog) 302 85.00% ARP40369_P050 B1WBD3_XENLA LOC100158432 protein Xenopus laevis (African clawed frog) 968 78.00% fli1a P100831_P050 B7ZS18_XENLA XLFli protein Xenopus laevis (African clawed frog) 453 85.00% Xenopus tropicalis (Western clawed frog) fli1a P100831_P050 A4IHU3_XENTR Fli1 protein (Silurana tropicalis) 459 85.00% Retroviral integration site protein Fli‐1 fli1a P100831_P050 FLI1_XENLA homolog Xenopus laevis (African clawed frog) 453 85.00% P100821_P050 A1L2H8_XENLA LOC100036852 protein Xenopus laevis (African clawed frog) 426 85.00% ARP49027_P050 Q6GPK1_XENLA MGC83622 protein Xenopus laevis (African clawed frog) 401 85.00% ARP49027_P050 Q6DCG1_XENLA LOC446305 protein (Fragment) Xenopus laevis (African clawed frog) 401 85.00% UDP‐GlcNAc:betaGal beta‐1,3‐N‐ Xenopus tropicalis (Western clawed frog) ARP49027_P050 Q6NX15_XENTR acetylglucosaminyltransferase 7 (Silurana tropicalis) 399 78.00% ARP40901_P050 Q6GP12_XENLA MGC80749 protein Xenopus laevis (African clawed frog) 350 83.00% Keap1 protein (Kelch‐like ECH‐associated Xenopus tropicalis (Western clawed frog) Keap1 ARP34728_T100 Q66JI3_XENTR protein 1) (Silurana tropicalis) 613 85.00% Keap1 ARP34728_T100 Q5HZR3_XENLA LOC496326 protein Xenopus laevis (African clawed frog) 613 85.00% Xenopus tropicalis (Western clawed frog) Pir ARP33665_T100 Q5I0B8_XENTR Pirin (Silurana tropicalis) 291 85.00% Pir ARP33665_T100 Q7ZX61_XENLA MGC53094 protein Xenopus laevis (African clawed frog) 290 78.00% Xenopus tropicalis (Western clawed frog) ARP38192_T100 Q6P380_XENTR Putative uncharacterized protein MGC75584 (Silurana tropicalis) 414 100.00% ARP38192_T100 Q6GQB7_XENLA MGC80185 protein Xenopus laevis (African clawed frog) 415 100.00% ARP38192_T100 Q6AZU7_XENLA Putative uncharacterized protein Xenopus laevis (African clawed frog) 414 100.00% 26S protease regulatory subunit 8 (26S proteasome AAA‐ATPase subunit RPT6) (Proteasome 26S subunit ATPase 5) (SUG1 ARP38192_T100 PRS8_XENLA homolog) (xSUG1) Xenopus laevis (African clawed frog) 461 100.00% VDAC ARP35122_T100 Q7ZWZ0_XENLA Vdac1‐prov protein Xenopus laevis (African clawed frog) 283 92.00% Xenopus tropicalis (Western clawed frog) VDAC ARP35122_T100 Q28HL9_XENTR Voltage‐dependent anion channel 1 (Silurana tropicalis) 283 92.00% Xenopus tropicalis (Western clawed frog) VDAC ARP35122_T100 A4QNE8_XENTR Vdac1 protein (Fragment) (Silurana tropicalis) 282 92.00% VDAC ARP35122_T100 Q52KY1_XENLA Vdac2 protein Xenopus laevis (African clawed frog) 283 92.00% Xenopus tropicalis (Western clawed frog) VDAC ARP35122_T100 Q07G51_XENTR Voltage‐dependent anion channel 2 (Silurana tropicalis) 283 92.00% Voltage‐dependent anion‐selective channel protein 2 (VDAC‐2) (Outer mitochondrial VDAC ARP35122_T100 VDAC2_XENLA membrane protein porin) Xenopus laevis (African clawed frog) 282 92.00%

Zinc finger CCCH domain‐containing protein zc3h15 ARP50635_P050 ZC3HF_XENLA 15 (DRG family‐regulatory protein 1) Xenopus laevis (African clawed frog) 426 78.00% Zinc finger CCCH domain‐containing protein Xenopus tropicalis (Western clawed frog) zc3h15 ARP50635_P050 ZC3HF_XENTR 15 (Silurana tropicalis) 426 90.00% ORF Names:ACLA_012760 EMBL EAW12848.1OrganismAspergillus clavatus ARP41683_P050 Q3B8H9_XENLA LOC398014 protein Xenopus laevis (African clawed frog) 418 92.00% ORF Names:ACLA_012760 EMBL EAW12848.1OrganismAspergillus Ferrochelatase, mitochondrial (EC 4.99.1.1) clavatus ARP41683_P050 HEMH_XENLA (Heme synthase) (Protoheme ferro‐lyase) Xenopus laevis (African clawed frog) 411 92.00% stk39 ARP48744_T100 Q6DD77_XENLA Stk39‐prov protein Xenopus laevis (African clawed frog) 527 85.00% stk39 ARP48744_T100 A0JPG0_XENLA Stk39 protein Xenopus laevis (African clawed frog) 528 85.00% stk39 ARP48744_T100 Q6DD36_XENLA Osr1‐prov protein Xenopus laevis (African clawed frog) 528 90.00% Serine threonine kinase 39 (STE20/SPS1 Xenopus tropicalis (Western clawed frog) stk39 ARP48744_T100 Q6NVS1_XENTR homolog) (Silurana tropicalis) 526 90.00% ARP54634_P050 Q6GLL1_XENLA LOC443714 protein (Fragment) Xenopus laevis (African clawed frog) 462 78.00% ARP54634_P050 B7ZQF5_XENLA Putative uncharacterized protein Xenopus laevis (African clawed frog) 379 78.00% ARP54634_P050 Q90WN6_XENLA G‐protein alpha subunit Xenopus laevis (African clawed frog) 379 78.00% ARP54634_P050 B7ZR45_XENLA GNAS complex locus Xenopus laevis (African clawed frog) 379 75.00% Guanine nucleotide‐binding protein G(s) subunit alpha (Adenylate cyclase‐stimulating ARP54634_P050 GNAS_XENLA G alpha protein) Xenopus laevis (African clawed frog) 379 75.00%

ORF Names:v1g200895OrganismNematostel Mediator of RNA polymerase II transcription Xenopus tropicalis (Western clawed frog) la vectensis (Starlet sea anemone) ARP50561_P050 MED4_XENTR subunit 4 (Mediator complex subunit 4) (Silurana tropicalis) 252 100.00%

ORF Names:v1g200895OrganismNematostel Mediator of RNA polymerase II transcription la vectensis (Starlet sea anemone) ARP50561_P050 MED4_XENLA subunit 4 (Mediator complex subunit 4) Xenopus laevis (African clawed frog) 252 100.00% pcm1 ARP48668_T100 Q5U253_XENLA LOC495685 protein Xenopus laevis (African clawed frog) 228 100.00% Xenopus tropicalis (Western clawed frog) pcm1 ARP48668_T100 Q5BKH1_XENTR Pcmt1 protein (Silurana tropicalis) 228 100.00% pcm1 ARP48668_T100 Q7SZS4_XENLA Pcmt1‐prov protein Xenopus laevis (African clawed frog) 228 78.00% Xenopus tropicalis (Western clawed frog) pqlc1.1 ARP49922_P050 A4IGL5_XENTR Putative uncharacterized protein (Silurana tropicalis) 271 78.00% pqlc1.1 ARP49922_P050 PQLC1_XENLA PQ‐loop repeat‐containing protein 1 Xenopus laevis (African clawed frog) 250 78.00% Xenopus tropicalis (Western clawed frog) ARP33683_P050 MAFB_XENTR Transcription factor MafB (Maf‐B) (XMafB) (Silurana tropicalis) 316 100.00%

ARP33683_P050 MAFB_XENLA Transcription factor MafB (Maf‐B) (XMafB) Xenopus laevis (African clawed frog) 313 92.00% ARP54604_P050 Q6IRR5_XENLA MGC80045 protein Xenopus laevis (African clawed frog) 133 100.00%

Finkel‐Biskis‐Reilly murine sarcoma virus (FBR‐ Xenopus tropicalis (Western clawed frog) ARP54604_P050 Q6AZL1_XENTR MuSV) ubiquitously expressed (Fox derived) (Silurana tropicalis) 133 100.00% ARP54604_P050 Q4KLF0_XENLA MGC116435 protein Xenopus laevis (African clawed frog) 133 100.00% Xenopus tropicalis (Western clawed frog) ARP54604_P050 A9UMA4_XENTR LOC100135288 protein (Silurana tropicalis) 133 100.00% pdhC ARP51995_P050 Q642P5_XENLA MGC85493 protein Xenopus laevis (African clawed frog) 492 92.00%

Dihydrolipoyllysine‐residue Dihydrolipoamide Xenopus tropicalis (Western clawed frog) pdhC ARP51995_P050 Q28E15_XENTR branched chain transacylase (BCKAD E2) (Silurana tropicalis) 492 92.00% RBM12 ARP40622_P050 Q6XD55_XENLA SWAN ribonucleoprotein Xenopus laevis (African clawed frog) 877 85.00% RBM12 ARP40622_P050 Q6PCK5_XENLA Rbm12‐prov protein Xenopus laevis (African clawed frog) 877 85.00% Ptpra ARP45366_P050 Q91556_XENLA Protein tyrosine phosphatase alpha Xenopus laevis (African clawed frog) 822 100.00% Ptpra ARP45366_P050 Q52L02_XENLA Ptpra protein Xenopus laevis (African clawed frog) 819 100.00% Ptpra ARP45366_P050 Q52KD2_XENLA Ptpa‐A‐prov protein Xenopus laevis (African clawed frog) 822 100.00% Xenopus tropicalis (Western clawed frog) Ptpra ARP45366_P050 B2GU66_XENTR LOC100158513 protein (Silurana tropicalis) 819 100.00% Mta3 ARP37737_T100 Q640Z4_XENLA MGC83916 protein Xenopus laevis (African clawed frog) 624 100.00% Xenopus tropicalis (Western clawed frog) Mta3 ARP37737_T100 Q5U4R0_XENTR Metastasis associated 1 (Silurana tropicalis) 639 100.00% Mta3 ARP37737_T100 Q9PUN0_XENLA Metastasis associated 1‐like protein Xenopus laevis (African clawed frog) 670 85.00% Mta3 ARP37737_T100 Q6AZP0_XENLA MGC83056 protein Xenopus laevis (African clawed frog) 672 85.00% Mta3 ARP37737_T100 Q4V7T0_XENLA Mta2 protein Xenopus laevis (African clawed frog) 669 85.00% LOC100170454 ARP45860_P050 Q0IHD0_XENLA MGC154448 protein Xenopus laevis (African clawed frog) 297 85.00% Xenopus tropicalis (Western clawed frog) LOC100170454 ARP45860_P050 B3DL45_XENTR LOC100170454 protein (Silurana tropicalis) 293 85.00% Cleavage stimulation factor, 3' pre‐RNA, Xenopus tropicalis (Western clawed frog) Cstf3 ARP40353_P050 Q6P4J1_XENTR subunit 3, 77kDa (Silurana tropicalis) 718 100.00% Cstf3 ARP40353_P050 Q6DDM9_XENLA Cstf3‐prov protein Xenopus laevis (African clawed frog) 718 100.00% Cleavage stimulation factor, 3' pre‐RNA, Cstf3 ARP40353_P050 Q4A1D1_XENLA subunit 3, 77kDa Xenopus laevis (African clawed frog) 719 100.00% ARP44365_T100 Q7SZ26_XENLA Ppib‐prov protein Xenopus laevis (African clawed frog) 216 85.00% ARP44365_T100 Q5XGR3_XENLA LOC495270 protein Xenopus laevis (African clawed frog) 216 85.00% Peptidylprolyl isomerase B, cyclophilin B ARP44365_T100 B2L4J6_XENBO (Fragment) Xenopus borealis (Kenyan clawed frog) 34 85.00% Xenopus tropicalis (Western clawed frog) ARP44365_T100 Q28G13_XENTR Peptidylprolyl isomerase B (Cyclophilin B) (Silurana tropicalis) 208 83.00% AVARP09002_T100 Q7ZXP6_XENLA Hsp47‐prov protein Xenopus laevis (African clawed frog) 419 91.00% Homeobox protein OTX2‐B (xOTX2‐B) (Orthodenticle 2‐B) (Orthodenticle‐A‐like otx2 ARP31414_P050 OTX2B_XENLA protein B) Xenopus laevis (African clawed frog) 289 92.00% Xenopus tropicalis (Western clawed frog) otx2 ARP31414_P050 B1H3B9_XENTR Cone‐rod homeobox (Silurana tropicalis) 290 100.00% Homeobox protein otx5 (Orthodenticle Xenopus tropicalis (Western clawed frog) otx2 ARP31414_P050 OTX5_XENTR homolog 5) (Silurana tropicalis) 290 100.00% Homeobox protein otx5‐B (Orthodenticle otx2 ARP31414_P050 OTX5B_XENLA homolog 5‐B) (XOtx5b) Xenopus laevis (African clawed frog) 290 100.00% Homeobox protein otx5‐A (Orthodenticle otx2 ARP31414_P050 OTX5A_XENLA homolog 5‐A) (Xotx5) Xenopus laevis (African clawed frog) 290 100.00% Homeobox protein OTX2‐A (xOTX2‐A) (Orthodenticle 2‐A) (Orthodenticle‐A‐like otx2 ARP31414_P050 OTX2A_XENLA protein A) Xenopus laevis (African clawed frog) 288 85.00% Xenopus tropicalis (Western clawed frog) otx2 ARP31414_P050 OTX2_XENTR Homeobox protein OTX2 (Orthodenticle 2) (Silurana tropicalis) 289 85.00% otx2 ARP31414_P050 Q98SI7_XENLA Transcription factor Otx1 Xenopus laevis (African clawed frog) 339 91.00% Xenopus tropicalis (Western clawed frog) otx2 ARP31414_P050 Q6P4Y7_XENTR Orthodenticle homeobox 1 (Silurana tropicalis) 336 91.00% otx2 ARP31414_P050 Q0IH93_XENLA Otx1‐A protein Xenopus laevis (African clawed frog) 338 91.00%

Ordered Locus Electron transferring flavoprotein, alpha Names:Bcen2424_1063OrganismBurkh polypeptide (Putative uncharacterized protein Xenopus tropicalis (Western clawed frog) olderia cenocepacia (strain HI2424) ARP54290_P050 Q28J91_XENTR LOC549492) (Silurana tropicalis) 333 100.00%

Ordered Locus Names:Bcen2424_1063OrganismBurkh olderia cenocepacia (strain HI2424) ARP54290_P050 Q5M989_XENLA LOC496165 protein (Fragment) Xenopus laevis (African clawed frog) 330 92.00%

Ordered Locus Names:Bcen2424_1063OrganismBurkh olderia cenocepacia (strain HI2424) ARP54290_P050 Q4QR22_XENLA MGC114925 protein Xenopus laevis (African clawed frog) 333 92.00%

Ordered Locus Names:Bcen2424_1063OrganismBurkh olderia cenocepacia (strain HI2424) ARP54290_P050 Q3KQG0_XENLA LOC496165 protein Xenopus laevis (African clawed frog) 333 92.00% Ordered Locus Names:Bcen2424_1063OrganismBurkh olderia cenocepacia (strain HI2424) ARP54290_P050 Q05AW5_XENLA MGC154518 protein Xenopus laevis (African clawed frog) 330 100.00% Bdnf protein (Brain derived neurotrophic Bdnf ARP41970_P050 Q63ZM5_XENLA factor) Xenopus laevis (African clawed frog) 247 100.00% Xenopus tropicalis (Western clawed frog) Bdnf ARP41970_P050 A3FPG9_XENTR Brain‐derived neurotrophic factor (Silurana tropicalis) 247 100.00% Xenopus tropicalis (Western clawed frog) Tspan6 ARP45454_P050 Q28C54_XENTR Tetraspanin 6 (Silurana tropicalis) 252 78.00% Xenopus tropicalis (Western clawed frog) GABRG2 ARP35574_T100 Q0VFL2_XENTR Gabrg1 protein (Fragment) (Silurana tropicalis) 374 92.00% Xenopus tropicalis (Western clawed frog) ARP45649_P050 Q28DY5_XENTR Oxysterol binding protein‐like 3 (Fragment) (Silurana tropicalis) 266 78.00% Xenopus tropicalis (Western clawed frog) ARP45649_P050 B0JZ53_XENTR Putative uncharacterized protein (Fragment) (Silurana tropicalis) 290 78.00% Xenopus tropicalis (Western clawed frog) ARP40965_T100 Q0P4U3_XENTR Polypyrimidine tract binding protein 2 (Silurana tropicalis) 531 85.00% Xenopus tropicalis (Western clawed frog) RNF121 ARP43252_T100 RN121_XENTR RING finger protein 121 (Silurana tropicalis) 327 85.00% Xenopus tropicalis (Western clawed frog) slc25a46 ARP44094_T100 S2546_XENTR Solute carrier family 25 member 46 (Silurana tropicalis) 416 100.00% slc25a46 ARP44094_T100 S246A_XENLA Solute carrier family 25 member 46‐A Xenopus laevis (African clawed frog) 417 100.00% slc25a46 ARP44094_T100 S246B_XENLA Solute carrier family 25 member 46‐B Xenopus laevis (African clawed frog) 414 92.00% Ionotropic glutamate receptor subunit GRIK1 ARP35340_T100 B9V8S1_XENLA GluR6(Q) Xenopus laevis (African clawed frog) 908 85.00% Xenopus tropicalis (Western clawed frog) NFIL3 ARP31177_P050 NFIL3_XENTR Nuclear factor interleukin‐3‐regulated protein (Silurana tropicalis) 462 92.00%

NFIL3 ARP31177_P050 NFIL3_XENLA Nuclear factor interleukin‐3‐regulated protein Xenopus laevis (African clawed frog) 456 85.00% SRY (Sex determining region Y)‐box 7, xSox7 ARP39667_P050 B7ZSI1_XENLA protein Xenopus laevis (African clawed frog) 362 100.00% SRY (Sex determining region Y)‐box 7, xSox7 ARP39667_P050 B7ZSI0_XENLA protein Xenopus laevis (African clawed frog) 362 100.00% Xenopus tropicalis (Western clawed frog) ARP39667_P050 SOX7_XENTR Transcription factor Sox‐7 (Silurana tropicalis) 362 100.00% ARP39667_P050 SOX7_XENLA Transcription factor Sox‐7 (xSOX7) Xenopus laevis (African clawed frog) 362 100.00% ARP39667_P050 A9J6L0_9PIPI Xsox17‐alpha1 protein Xenopus gilli (Cape clawed frog) 245 92.00%

Transcription factor Sox‐18B (xSox18beta) ARP39667_P050 SX18B_XENLA (SRY (sex determining region Y)‐box 18B) Xenopus laevis (African clawed frog) 361 92.00% Transcription factor Sox‐18A (xSox18alpha) ARP39667_P050 SX18A_XENLA (SRY (sex determining region Y)‐box 18A) Xenopus laevis (African clawed frog) 363 92.00% Transcription factor Sox‐17‐alpha Xenopus tropicalis (Western clawed frog) ARP39667_P050 SX17A_XENTR (Sox17alpha) (tSox17alpha) (Silurana tropicalis) 383 92.00% Transcription factor Sox‐18 (SRY (sex Xenopus tropicalis (Western clawed frog) ARP39667_P050 SOX18_XENTR determining region Y)‐box 18) (Silurana tropicalis) 362 92.00%

Transcription factor Sox‐17‐beta.3 (SRY (sex Xenopus tropicalis (Western clawed frog) ARP39667_P050 S17B3_XENTR determining region Y)‐box 17‐beta.3) (Silurana tropicalis) 376 92.00%

Transcription factor Sox‐17‐beta.3 (SRY (sex ARP39667_P050 S17B3_XENLA determining region Y)‐box 17‐beta.3) Xenopus laevis (African clawed frog) 373 92.00%

Transcription factor Sox‐17‐beta.2 (SRY (sex Xenopus tropicalis (Western clawed frog) ARP39667_P050 S17B2_XENTR determining region Y)‐box 17‐beta.2) (Silurana tropicalis) 373 92.00% Transcription factor Sox‐17‐beta.1 (SRY (sex determining region Y)‐box 17‐beta.1) Xenopus tropicalis (Western clawed frog) ARP39667_P050 S17B1_XENTR (tSox17beta) (Silurana tropicalis) 376 92.00% Transcription factor Sox‐17‐beta.1 (SRY (sex determining region Y)‐box 17‐beta.1) (Transcription factor Sox‐17‐beta) ARP39667_P050 S17B1_XENLA (XSox17beta) Xenopus laevis (African clawed frog) 373 92.00% Transcription factor Sox‐17‐alpha‐B ARP39667_P050 S17AB_XENLA (xSox17alpha2) Xenopus laevis (African clawed frog) 377 92.00% Transcription factor Sox‐17‐alpha‐A ARP39667_P050 S17AA_XENLA (Xsox17alpha) (xSox17alpha1) Xenopus laevis (African clawed frog) 380 92.00% SLC22A1 ARP41516_T100 Q66J42_XENLA MGC82013 protein Xenopus laevis (African clawed frog) 550 85.00% SLC22A1 ARP41516_T100 Q6P7H9_XENLA MGC68647 protein Xenopus laevis (African clawed frog) 314 78.00% Xenopus tropicalis (Western clawed frog) csgalnact2 ARP47434_P050 A4IHS3_XENTR LOC100124741 protein (Silurana tropicalis) 378 92.00% dcn ARP48200_P050 Q6GNX8_XENLA MGC80802 protein Xenopus laevis (African clawed frog) 364 84.00% dcn ARP48200_P050 Q66J59_XENLA MGC81824 protein Xenopus laevis (African clawed frog) 364 84.00% Xenopus tropicalis (Western clawed frog) dcn ARP48200_P050 A4IIC2_XENTR Dcn protein (Silurana tropicalis) 364 84.00% MBD3 ARP40169_T100 Q9PUM9_XENLA Methyl‐CpG binding protein MBD3 Xenopus laevis (African clawed frog) 282 92.00% MBD3 ARP40169_T100 Q8AYP2_XENLA Methyl‐CpG binding protein MBD3 Xenopus laevis (African clawed frog) 283 92.00% MBD3 ARP40169_T100 Q8AYT1_XENLA Methyl‐CpG binding protein MBD2 Xenopus laevis (African clawed frog) 267 85.00%

HOXB1 ARP39596_P050 Q9PSI3_XENLA XHOX2.9 homeodomain protein (Fragment) Xenopus laevis (African clawed frog) 66 100.00% Xenopus tropicalis (Western clawed frog) HOXB1 ARP39596_P050 HXD1_XENTR Homeobox protein Hox‐D1 (Silurana tropicalis) 301 100.00% Homeobox protein Hox‐D1 (Hox.lab1) (Labial HOXB1 ARP39596_P050 HXD1_XENLA protein) (Xlab) Xenopus laevis (African clawed frog) 300 100.00% HOXB1 ARP39596_P050 Q7ZXI1_XENLA Hoxa1‐A protein Xenopus laevis (African clawed frog) 324 100.00% Xenopus tropicalis (Western clawed frog) HOXB1 ARP39596_P050 Q642T9_XENTR (Silurana tropicalis) 323 100.00% Homeobox protein Hox‐A1 (Hox.lab2) HOXB1 ARP39596_P050 HXA1_XENLA (Fragment) Xenopus laevis (African clawed frog) 240 100.00% HOXB1 ARP39596_P050 Q90YE0_XENLA Homeobox protein Hox A11 (Fragment) Xenopus laevis (African clawed frog) 185 75.00% HOXB1 ARP39596_P050 Q1RMD8_XENLA MGC131014 protein Xenopus laevis (African clawed frog) 274 75.00% Homeobox containing transcription factor HOXB1 ARP39596_P050 O73794_XENLA (Fragment) Xenopus laevis (African clawed frog) 63 75.00% Xenopus tropicalis (Western clawed frog) dfd‐2 ARP39379_P050 Q5M797_XENTR Homeobox A5 (Silurana tropicalis) 274 92.00% dfd‐2 ARP39379_P050 Q08B46_XENLA Hoxc5‐A protein Xenopus laevis (African clawed frog) 226 92.00% dfd‐2 ARP39379_P050 Q05AW4_XENLA Hoxb6 protein Xenopus laevis (African clawed frog) 223 92.00% Xenopus tropicalis (Western clawed frog) dfd‐2 ARP39379_P050 A4QNI0_XENTR Hoxb5 protein (Silurana tropicalis) 258 92.00% Homeobox protein Hox‐C5 (XlHbox‐5) dfd‐2 ARP39379_P050 HXC5_XENLA (Fragment) Xenopus laevis (African clawed frog) 87 92.00% Homeobox protein Hox‐B6 (XlHox‐2.2) dfd‐2 ARP39379_P050 HXB6_XENLA (Fragment) Xenopus laevis (African clawed frog) 48 92.00% Homeobox protein Hox‐B5 (Xhox‐1B) (XlHbox‐ dfd‐2 ARP39379_P050 HXB5_XENLA 4) (Fragment) Xenopus laevis (African clawed frog) 230 92.00% dfd‐2 ARP39379_P050 Q6TGB6_XENLA HOXD4 (Fragment) Xenopus laevis (African clawed frog) 218 92.00% Xenopus tropicalis (Western clawed frog) dfd‐2 ARP39379_P050 Q5EB31_XENTR Hoxb4 protein (Fragment) (Silurana tropicalis) 233 92.00% dfd‐2 ARP39379_P050 Q4QR28_XENLA Hoxb7 protein Xenopus laevis (African clawed frog) 221 85.00% dfd‐2 ARP39379_P050 Q2TAR0_XENLA Putative uncharacterized protein Xenopus laevis (African clawed frog) 237 92.00% dfd‐2 ARP39379_P050 B8XR32_XENLA Homeobox protein Hoxb‐4 (Fragment) Xenopus laevis (African clawed frog) 230 92.00% Antp ARP39580_P050 Q4QR28_XENLA Hoxb7 protein Xenopus laevis (African clawed frog) 221 100.00% Homeobox protein Hox‐B7‐B (P52) (XlHbox‐2 Antp ARP39580_P050 HXB7B_XENLA B) Xenopus laevis (African clawed frog) 220 100.00% Homeobox protein Hox‐B7‐A (MM3) (XlHbox‐ Antp ARP39580_P050 HXB7A_XENLA 2 A) Xenopus laevis (African clawed frog) 220 100.00% Xenopus tropicalis (Western clawed frog) Antp ARP39580_P050 Q5M797_XENTR Homeobox A5 (Silurana tropicalis) 274 92.00% Xenopus tropicalis (Western clawed frog) Antp ARP39580_P050 A4QNI0_XENTR Hoxb5 protein (Silurana tropicalis) 258 92.00% GK12358 ARP38092_P050 Q6GNT4_XENLA LOC443646 protein (Fragment) Xenopus laevis (African clawed frog) 247 78.00%

Histone‐lysine N‐methyltransferase EZH2 (EC Xenopus tropicalis (Western clawed frog) GK12358 ARP38092_P050 EZH2_XENTR 2.1.1.43) (Enhancer of zeste homolog 2) (Silurana tropicalis) 748 78.00% Histone‐lysine N‐methyltransferase EZH2 (EC GK12358 ARP38092_P050 EZH2B_XENLA 2.1.1.43) (Enhancer of zeste homolog 2‐B) Xenopus laevis (African clawed frog) 748 78.00% ORF Names:PANDA_001752 EMBL EFB27632.1OrganismAiluropoda melanoleuca (Giant panda) P100611_P050 Q9DFC1_XENLA Homeobox protein XHox11 Xenopus laevis (African clawed frog) 312 100.00% Xenopus tropicalis (Western clawed frog) VDAC2 ARP35123_P050 Q5M8U0_XENTR Voltage‐dependent anion channel 3 (Silurana tropicalis) 283 92.00% VDAC2 ARP35123_P050 Q52KY1_XENLA Vdac2 protein Xenopus laevis (African clawed frog) 283 92.00% Xenopus tropicalis (Western clawed frog) VDAC2 ARP35123_P050 Q07G51_XENTR Voltage‐dependent anion channel 2 (Silurana tropicalis) 283 92.00% Voltage‐dependent anion‐selective channel protein 2 (VDAC‐2) (Outer mitochondrial VDAC2 ARP35123_P050 VDAC2_XENLA membrane protein porin) Xenopus laevis (African clawed frog) 282 92.00% VDAC2 ARP35123_P050 Q6GR11_XENLA MGC81430 protein Xenopus laevis (African clawed frog) 283 85.00% Xenopus tropicalis (Western clawed frog) VDAC2 ARP35123_P050 Q28HL9_XENTR Voltage‐dependent anion channel 1 (Silurana tropicalis) 283 85.00% Xenopus tropicalis (Western clawed frog) VDAC2 ARP35123_P050 A4QNE8_XENTR Vdac1 protein (Fragment) (Silurana tropicalis) 282 85.00% VDAC2 ARP35123_P050 Q7ZWZ0_XENLA Vdac1‐prov protein Xenopus laevis (African clawed frog) 283 78.00% ARP55267_P050 Q66KV1_XENLA MGC85408 protein Xenopus laevis (African clawed frog) 277 92.00% Insulin‐like growth factor I receptor IGF‐IR AVARP00004_P050 Q91776_XENLA (Fragment) Xenopus laevis (African clawed frog) 609 100.00% IGF‐IR AVARP00004_P050 B7ZSL0_XENLA LOC398022 protein Xenopus laevis (African clawed frog) 1363 100.00%

Insulin‐like growth factor 1 receptor (xIGF‐1R) (xIGFR) (EC 2.7.10.1) [Cleaved into: Insulin‐like growth factor 1 receptor alpha chain; Insulin‐ IGF‐IR AVARP00004_P050 IGF1R_XENLA like growth factor 1 receptor beta chain] Xenopus laevis (African clawed frog) 1358 100.00% IGF‐IR AVARP00004_P050 B7ZS80_XENLA Insulin receptor, beta‐subunit Xenopus laevis (African clawed frog) 1362 78.00%

Insulin receptor (IR) (EC 2.7.10.1) (XTK‐1b) (Xe‐ InsR) [Cleaved into: Insulin receptor subunit IGF‐IR AVARP00004_P050 INSR_XENLA alpha; Insulin receptor subunit beta] Xenopus laevis (African clawed frog) 1362 78.00% ARP43935_T100 Q7ZXP5_XENLA Mct3‐prov protein Xenopus laevis (African clawed frog) 472 85.00% ARP43935_T100 Q6GM98_XENLA MGC81989 protein Xenopus laevis (African clawed frog) 472 78.00% Solute carrier family 16, member 3 Xenopus tropicalis (Western clawed frog) ARP43935_T100 Q66KK7_XENTR (Monocarboxylic acid transporter 4) (Silurana tropicalis) 473 78.00% Xenopus tropicalis (Western clawed frog) ARP44691_P050 Q5BL58_XENTR MGC69500 protein (Silurana tropicalis) 738 92.00% ARP44691_P050 Q4KLV0_XENLA MGC114983 protein Xenopus laevis (African clawed frog) 754 92.00% Erlin‐1 (Endoplasmic reticulum lipid raft‐ associated protein 1) (Stomatin‐prohibitin‐ flotillin‐HflC/K domain‐containing protein 1) Xenopus tropicalis (Western clawed frog) erlin2 ARP46725_P050 ERLN1_XENTR (SPFH domain‐containing protein 1) (Silurana tropicalis) 319 84.00%

Erlin‐2 (Endoplasmic reticulum lipid raft‐ associated protein 2) (Stomatin‐prohibitin‐ flotillin‐HflC/K domain‐containing protein 2) Xenopus tropicalis (Western clawed frog) erlin2 ARP46725_P050 ERLN2_XENTR (SPFH domain‐containing protein 2) (Silurana tropicalis) 335 84.00%

Erlin‐2‐B (Endoplasmic reticulum lipid raft‐ associated protein 2‐B) (Stomatin‐prohibitin‐ flotillin‐HflC/K domain‐containing protein 2‐B) erlin2 ARP46725_P050 ERL2B_XENLA (SPFH domain‐containing protein 2‐B) Xenopus laevis (African clawed frog) 330 84.00%

Erlin‐2‐A (Endoplasmic reticulum lipid raft‐ associated protein 2‐A) (Stomatin‐prohibitin‐ flotillin‐HflC/K domain‐containing protein 2‐A) erlin2 ARP46725_P050 ERL2A_XENLA (SPFH domain‐containing protein 2‐A) Xenopus laevis (African clawed frog) 335 76.00% Ionotropic glutamate receptor subunit ARP35515_T100 B9V8S1_XENLA GluR6(Q) Xenopus laevis (African clawed frog) 908 100.00% Transcription factor Sox‐6 (SRY (sex Xenopus tropicalis (Western clawed frog) SOX6 ARP33148_P050 SOX6_XENTR determining region Y)‐box 6) (Silurana tropicalis) 777 92.00% Ordered Locus Names:Spea_2523OrganismShewanella pealeana (strain ATCC 700345 / ANG‐ Xenopus tropicalis (Western clawed frog) SQ1) ARP44440_P050 Q5EBF4_XENTR MGC108303 protein (Silurana tropicalis) 693 100.00% ORF Names:LELG_03302 EMBL EDK45123.1OrganismLodderomyces elongisporus (Yeast) (Saccharomyces Xenopus tropicalis (Western clawed frog) elongisporus) ARP40711_P050 B5DFQ7_XENTR Putative uncharacterized protein (Silurana tropicalis) 962 92.00% ARP48431_P050 Q7SZT8_XENLA Gpsn2‐prov protein Xenopus laevis (African clawed frog) 308 78.00% ARP48431_P050 Q6GP78_XENLA MGC80625 protein Xenopus laevis (African clawed frog) 308 78.00% Xenopus tropicalis (Western clawed frog) ARP48431_P050 Q68EQ7_XENTR Gpsn2 protein (Silurana tropicalis) 308 78.00% Xenopus tropicalis (Western clawed frog) ARP48431_P050 Q5BKP0_XENTR Gpsn2 protein (Silurana tropicalis) 346 78.00% Xenopus tropicalis (Western clawed frog) ARP48431_P050 Q05B15_XENTR Putative uncharacterized protein MGC146850 (Silurana tropicalis) 312 83.00% Xenopus tropicalis (Western clawed frog) ARP52220_P050 Q0VA47_XENTR WAS , member 3 (Silurana tropicalis) 502 100.00% Xenopus tropicalis (Western clawed frog) cpsf2 ARP40857_P050 B1H337_XENTR LOC100145546 protein (Silurana tropicalis) 783 100.00% Cleavage and polyadenylation specificity factor subunit 2 (Cleavage and polyadenylation specificity factor 100 kDa cpsf2 ARP40857_P050 CPSF2_XENLA subunit) (CPSF 100 kDa subunit) Xenopus laevis (African clawed frog) 783 100.00% Bcap31 ARP46645_P050 Q6DKC8_XENLA MGC84076 protein Xenopus laevis (African clawed frog) 244 84.00% Bcap31 ARP46645_P050 Q6DFT8_XENLA Bcap31 protein (Bcap31‐prov protein) Xenopus laevis (African clawed frog) 244 84.00% Xenopus tropicalis (Western clawed frog) Bcap31 ARP46645_P050 Q6P890_XENTR B‐cell receptor‐associated protein 31 (Silurana tropicalis) 244 84.00% eno1 ARP48204_P050 Q7ZXA3_XENLA Eno3‐prov protein Xenopus laevis (African clawed frog) 434 92.00% Mgc108129 protein (Putative uncharacterized Xenopus tropicalis (Western clawed frog) eno1 ARP48204_P050 Q4VA70_XENTR protein mgc108129) (Silurana tropicalis) 434 92.00% C130022K22Rik ARP56918_P050 Q6INS7_XENLA MGC81053 protein Xenopus laevis (African clawed frog) 358 92.00% ACTR1B ARP52099_P050 Q6DJH8_XENLA Actr1a‐prov protein Xenopus laevis (African clawed frog) 376 92.00% Xenopus tropicalis (Western clawed frog) ACTR1B ARP52099_P050 A9UMK9_XENTR Putative uncharacterized protein (Silurana tropicalis) 376 92.00% rfc3 ARP46084_P050 Q4QQP4_XENLA MGC115007 protein Xenopus laevis (African clawed frog) 356 100.00% hmgb3a ARP35766_T100 Q7ZY24_XENLA Hmgb3‐prov protein Xenopus laevis (African clawed frog) 202 100.00% High‐mobility group box 3 (MGC88931 Xenopus tropicalis (Western clawed frog) hmgb3a ARP35766_T100 Q6DJ93_XENTR protein) (Silurana tropicalis) 202 100.00% High mobility group B3b protein (LOC734200 hmgb3a ARP35766_T100 Q1XCD9_XENLA protein) Xenopus laevis (African clawed frog) 201 100.00% hmgb3a ARP35766_T100 B2L566_XENBO High mobility group box 3 (Fragment) Xenopus borealis (Kenyan clawed frog) 31 100.00% Xenopus tropicalis (Western clawed frog) hmgb3a ARP35766_T100 Q6P7M9_XENTR High‐mobility group box 2 (Silurana tropicalis) 212 84.00% hmgb3a ARP35766_T100 Q91764_XENLA HMG‐X protein Xenopus laevis (African clawed frog) 212 76.00% hmgb3a ARP35766_T100 Q91596_XENLA High mobility group protein‐1 Xenopus laevis (African clawed frog) 210 76.00% hmgb3a ARP35766_T100 Q8AVU3_XENLA MGC52825 protein Xenopus laevis (African clawed frog) 212 76.00% hmgb3a ARP35766_T100 Q7ZXK5_XENLA MGC52578 protein Xenopus laevis (African clawed frog) 212 76.00% hmgb3a ARP35766_T100 Q7SZ42_XENLA Hmgb1‐prov protein Xenopus laevis (African clawed frog) 211 76.00% Xenopus tropicalis (Western clawed frog) hmgb3a ARP35766_T100 Q6P4N5_XENTR High‐mobility group box 1 (Silurana tropicalis) 211 76.00% hmgb3a ARP35766_T100 Q6GNQ5_XENLA HMG‐1 protein Xenopus laevis (African clawed frog) 210 76.00% hmgb3a ARP35766_T100 Q32NS7_XENLA MGC52825 protein Xenopus laevis (African clawed frog) 211 76.00% hells ARP36449_P050 Q4V835_XENLA HELLS protein Xenopus laevis (African clawed frog) 838 85.00% Xenopus tropicalis (Western clawed frog) hells ARP36449_P050 B5DET7_XENTR Putative uncharacterized protein (Silurana tropicalis) 840 85.00% ORF Names:PANDA_009011 EMBL EFB16473.1OrganismAiluropoda melanoleuca (Giant panda) ARP50842_P050 Q6GLQ0_XENLA MGC84406 protein Xenopus laevis (African clawed frog) 783 78.00% Xenopus tropicalis (Western clawed frog) LOC100135339 ARP42290_P050 A9UMF6_XENTR LOC100135339 protein (Silurana tropicalis) 171 100.00% Xenopus tropicalis (Western clawed frog) LOC100135339 ARP42290_P050 AGR3_XENTR Anterior gradient protein 3 (Silurana tropicalis) 164 92.00% ARP47979_P050 Q6DCE9_XENLA MGC83480 protein Xenopus laevis (African clawed frog) 1071 100.00% ARP47979_P050 Q5HZP4_XENLA LOC496341 protein Xenopus laevis (African clawed frog) 1085 100.00% ARP47979_P050 Q6NTK5_XENLA LOC414498 protein (Fragment) Xenopus laevis (African clawed frog) 1139 92.00% ARP47979_P050 Q4KLW6_XENLA LOC414498 protein (Fragment) Xenopus laevis (African clawed frog) 1141 92.00% Xenopus tropicalis (Western clawed frog) ARP47979_P050 Q28CA9_XENTR Tumor protein p53 binding protein, 2 (Silurana tropicalis) 1101 92.00% Xenopus tropicalis (Western clawed frog) ARP47979_P050 B7ZU85_XENTR LOC548790 protein (Silurana tropicalis) 1110 92.00% ARP47979_P050 A1A5J5_XENLA LOC446947 protein Xenopus laevis (African clawed frog) 1111 92.00% ARP47979_P050 Q66IP5_XENLA LOC446947 protein (Fragment) Xenopus laevis (African clawed frog) 1125 85.00% ARP47979_P050 Q4KLV4_XENLA LOC446947 protein (Fragment) Xenopus laevis (African clawed frog) 1145 85.00% ARP47979_P050 Q2TAH3_XENLA LOC446947 protein (Fragment) Xenopus laevis (African clawed frog) 1143 85.00% ARP47979_P050 Q66KF0_XENLA MGC86497 protein Xenopus laevis (African clawed frog) 805 76.00%

Novel protein similar to protein phosphatase Xenopus tropicalis (Western clawed frog) ARP47979_P050 Q28C37_XENTR 1, regulatory (Inhibitor) subunit 13 like (Silurana tropicalis) 798 76.00% pstk ARP53154_P050 Q6GLP8_XENLA MGC84410 protein Xenopus laevis (African clawed frog) 382 100.00% Xenopus tropicalis (Western clawed frog) pstk ARP53154_P050 B2GUE1_XENTR LOC100158568 protein (Silurana tropicalis) 374 92.00% Bromodomain and PHD finger containing, 1 Xenopus tropicalis (Western clawed frog) Brpf1 ARP33563_P050 Q28DL2_XENTR (Fragment) (Silurana tropicalis) 484 85.00% Xenopus tropicalis (Western clawed frog) ARP34988_P050 A4IIN3_XENTR LOC100125027 protein (Silurana tropicalis) 474 100.00% Xenopus tropicalis (Western clawed frog) ARP34988_P050 A4IIK0_XENTR Gabrb3 protein (Silurana tropicalis) 475 100.00% HMG‐S_Bm ARP41562_T100 Q52MA3_XENLA Putative uncharacterized protein Xenopus laevis (African clawed frog) 520 78.00% Xenopus tropicalis (Western clawed frog) HMG‐S_Bm ARP41562_T100 B0JZH5_XENTR Hmgcs1 protein (Silurana tropicalis) 520 78.00% HMG‐S_Bm ARP41562_T100 Q7ZYN7_XENLA Hmgcs1‐prov protein Xenopus laevis (African clawed frog) 520 78.00% HMG‐S_Bm ARP41562_T100 Q6AX99_XENLA MGC80816 protein Xenopus laevis (African clawed frog) 520 78.00% si:dkey‐121j17.1 ARP55511_P050 Q6GN17_XENLA MGC83639 protein Xenopus laevis (African clawed frog) 455 85.00% LOC100135182 protein (Putative Xenopus tropicalis (Western clawed frog) si:dkey‐121j17.1 ARP55511_P050 A9ULC6_XENTR uncharacterized protein LOC100135182) (Silurana tropicalis) 433 85.00%

RCC2 ARP57290_P050 B9VQ38_XENLA Telophase disc 60 kDa protein (Fragment) Xenopus laevis (African clawed frog) 497 78.00% RCC2 ARP57290_P050 RCC2_XENLA Protein RCC2 homolog Xenopus laevis (African clawed frog) 513 78.00% LOC100036898 ARP54528_P050 Q6AX40_XENLA MGC86251 protein Xenopus laevis (African clawed frog) 507 92.00% LOC100036898 ARP54528_P050 A1L2N0_XENLA LOC100036898 protein (Fragment) Xenopus laevis (African clawed frog) 507 83.00% ORF Names:v1g129106OrganismNematostel la vectensis (Starlet sea anemone) ARP54612_P050 Q5M7B9_XENLA Fkbp3 protein (Fragment) Xenopus laevis (African clawed frog) 220 92.00%

ORF Names:v1g129106OrganismNematostel la vectensis (Starlet sea anemone) ARP54612_P050 Q3B8M1_XENLA Fkbp3 protein Xenopus laevis (African clawed frog) 225 92.00%

ORF Names:v1g129106OrganismNematostel Xenopus tropicalis (Western clawed frog) la vectensis (Starlet sea anemone) ARP54612_P050 Q28IB7_XENTR FK506 binding protein 3, 25kDa (Silurana tropicalis) 225 85.00% ORF Names:zgc:165474 EMBL AAI42810.1 ZFIN ZDB‐GENE‐070620‐ 9OrganismDanio rerio (Zebrafish) (Brachydanio rerio) ARP35432_P050 Q6AX29_XENLA MGC86330 protein Xenopus laevis (African clawed frog) 372 100.00% ARP41036_T100 Q7ZYE9_XENLA Hnrpab‐prov protein Xenopus laevis (African clawed frog) 324 78.00% Putative uncharacterized protein (Vg1 mRNA ARP41036_T100 Q6GM69_XENLA binding protein 40) Xenopus laevis (African clawed frog) 326 78.00% ARP41036_T100 Q645K2_XENLA P37 AUF1 Xenopus laevis (African clawed frog) 295 78.00% Xenopus tropicalis (Western clawed frog) ARP41036_T100 Q537I0_XENTR AUF1 (Silurana tropicalis) 295 78.00% ARP41036_T100 Q4V7K8_XENLA LOC496375 protein Xenopus laevis (African clawed frog) 286 78.00% lhx1 P100851_T100 D0UED4_XENLA LIM homeobox 1 (Fragment) Xenopus laevis (African clawed frog) 28 100.00% lhx1 P100851_T100 B7ZP59_XENLA Homeobox protein Xenopus laevis (African clawed frog) 403 100.00% Xenopus tropicalis (Western clawed frog) lhx1 P100851_T100 A4QNI6_XENTR Lhx1 protein (Silurana tropicalis) 409 100.00% LIM/homeobox protein Lhx1 (LIM homeobox protein 1) (Homeobox protein Lim‐1) (Xlim1) lhx1 P100851_T100 LHX1_XENLA (x‐Lhx1) (xLIM‐1) Xenopus laevis (African clawed frog) 403 100.00% Ordered Locus Names:Sfum_3057OrganismSyntropho bacter fumaroxidans (strain DSM 10017 / MPOB) ARP41657_P050 Q6GN55_XENLA MGC83017 protein Xenopus laevis (African clawed frog) 330 85.00% Ordered Locus Names:Sfum_3057OrganismSyntropho bacter fumaroxidans (strain DSM 10017 / MPOB) ARP41657_P050 Q6GLK5_XENLA MGC84775 protein Xenopus laevis (African clawed frog) 330 85.00% Ordered Locus Names:Sfum_3057OrganismSyntropho bacter fumaroxidans (strain DSM 10017 Xenopus tropicalis (Western clawed frog) / MPOB) ARP41657_P050 Q0VGV4_XENTR Delta‐aminolevulinic acid dehydratase (Silurana tropicalis) 330 85.00% ORF Names:PANDA_002368 EMBL EFB22780.1OrganismAiluropoda melanoleuca (Giant panda) ARP36019_T100 COE2B_XENLA Isoform 2 Xenopus laevis (African clawed frog) 572 91.00% ORF Names:PANDA_002368 EMBL EFB22780.1OrganismAiluropoda Transcription factor coe2 (Early B‐cell factor 2) Xenopus tropicalis (Western clawed frog) melanoleuca (Giant panda) ARP36019_T100 COE2_XENTR (EBF‐2) (Silurana tropicalis) 575 91.00% ORF Names:PANDA_002368 EMBL EFB22780.1OrganismAiluropoda Transcription factor coe2‐B (Xcoe2) (Early B‐ melanoleuca (Giant panda) ARP36019_T100 COE2B_XENLA cell factor 2‐B) (EBF‐2‐B) (Xebf‐2‐B) Xenopus laevis (African clawed frog) 580 91.00% ORF Names:PANDA_002368 EMBL EFB22780.1OrganismAiluropoda Transcription factor coe2‐A (Xcoe‐2) (Xcoe2) melanoleuca (Giant panda) ARP36019_T100 COE2A_XENLA (Early B‐cell factor 2‐A) (EBF‐2‐A) (Xebf‐2‐A) Xenopus laevis (African clawed frog) 575 83.00% si:ch73‐38f1.1 ARP36020_P050 COE2B_XENLA Isoform 2 Xenopus laevis (African clawed frog) 572 100.00% Transcription factor coe2 (Early B‐cell factor 2) Xenopus tropicalis (Western clawed frog) si:ch73‐38f1.1 ARP36020_P050 COE2_XENTR (EBF‐2) (Silurana tropicalis) 575 100.00%

Transcription factor coe2‐B (Xcoe2) (Early B‐ si:ch73‐38f1.1 ARP36020_P050 COE2B_XENLA cell factor 2‐B) (EBF‐2‐B) (Xebf‐2‐B) Xenopus laevis (African clawed frog) 580 100.00%

Transcription factor coe2‐A (Xcoe‐2) (Xcoe2) si:ch73‐38f1.1 ARP36020_P050 COE2A_XENLA (Early B‐cell factor 2‐A) (EBF‐2‐A) (Xebf‐2‐A) Xenopus laevis (African clawed frog) 575 92.00% si:ch73‐38f1.1 ARP36020_P050 B7ZRR5_XENLA Xebf‐3 protein Xenopus laevis (African clawed frog) 597 85.00% Xenopus tropicalis (Western clawed frog) si:ch73‐38f1.1 ARP36020_P050 A9ULR8_XENTR LOC100135240 protein (Fragment) (Silurana tropicalis) 496 85.00% Transcription factor COE3 (xCOE3) (Olf‐1/EBF‐ si:ch73‐38f1.1 ARP36020_P050 COE3_XENLA like 2) (OE‐2) (xEBF‐3) (xOE‐2) Xenopus laevis (African clawed frog) 598 85.00% Xenopus tropicalis (Western clawed frog) pde1b ARP53563_P050 A4IIT4_XENTR LOC100125056 protein (Silurana tropicalis) 538 100.00% pde1b ARP53563_P050 Q5U590_XENLA LOC495332 protein Xenopus laevis (African clawed frog) 250 78.00% Xenopus tropicalis (Western clawed frog) pde1b ARP53563_P050 A1L1D8_XENTR LOC100036722 protein (Silurana tropicalis) 533 78.00% Solute carrier family 27 (Fatty acid Xenopus tropicalis (Western clawed frog) slc27a6 ARP43781_P050 Q5M7Q7_XENTR transporter), member 6 (Silurana tropicalis) 621 100.00% Solute carrier family 27 fatty acid transporter Xenopus tropicalis (Western clawed frog) slc27a6 ARP43781_P050 Q28E33_XENTR member 6 (Silurana tropicalis) 621 100.00% slc27a6 ARP43781_P050 A9JS83_XENLA LOC100101306 protein (Fragment) Xenopus laevis (African clawed frog) 642 100.00% slc27a6 ARP43781_P050 A5PKQ8_XENLA LOC100101306 protein (Fragment) Xenopus laevis (African clawed frog) 650 100.00% slc27a6 ARP43781_P050 A0JMY7_XENLA MGC154930 protein Xenopus laevis (African clawed frog) 621 100.00% slc27a6 ARP43781_P050 Q8AVC5_XENLA LOC398483 protein (Fragment) Xenopus laevis (African clawed frog) 625 92.00% Xenopus tropicalis (Western clawed frog) slc27a6 ARP43781_P050 Q4QQR1_XENTR LOC613067 protein (Fragment) (Silurana tropicalis) 616 92.00% ORF Names:OENOO_59027 EMBL Adenosine monophosphate‐protein EAV39279.1OrganismOenococcus oeni transferase FICD (EC 2.7.7.n1) (AMPylator Xenopus tropicalis (Western clawed frog) ATCC BAA‐1163 ARP46825_T100 FICD_XENTR FICD) (FIC domain‐containing protein) (Silurana tropicalis) 446 92.00% Nuclear receptor subfamily 2 group C member 1 (Developmental orphan receptor 2) (DOR2) (Orphan nuclear receptor TR2) (Testicular Xenopus tropicalis (Western clawed frog) trr P100812_T100 NR2C1_XENTR receptor 2) (Silurana tropicalis) 636 85.00%

Nuclear receptor subfamily 2 group C member 1‐B (Developmental orphan receptor 2‐B) (DOR2‐B) (xDOR2‐B) (Orphan nuclear receptor trr P100812_T100 N2C1B_XENLA TR2‐B) (Testicular receptor 2‐B) Xenopus laevis (African clawed frog) 637 85.00%

Nuclear receptor subfamily 2 group C member 1‐A (Developmental orphan receptor 2‐A) (DOR2‐A) (xDOR2‐A) (Orphan nuclear receptor trr P100812_T100 N2C1A_XENLA TR2‐A) (Testicular receptor 2‐A) Xenopus laevis (African clawed frog) 637 85.00% Xenopus tropicalis (Western clawed frog) HTATIP2 ARP32774_T100 Q6DJ19_XENTR HIV‐1 Tat interactive protein 2, 30kDa (Silurana tropicalis) 239 85.00% HTATIP2 ARP32774_T100 Q4V7Q0_XENLA MGC115485 protein Xenopus laevis (African clawed frog) 239 85.00% Xenopus tropicalis (Western clawed frog) Cav1 P100998_P050 Q5EBF9_XENTR 1, protein, 22kDa (Silurana tropicalis) 180 81.00% Xenopus tropicalis (Western clawed frog) Cav1 P100998_P050 Q2QLF5_XENTR (Silurana tropicalis) 180 81.00% HoxC5 ARP39378_P050 Q08B46_XENLA Hoxc5‐A protein Xenopus laevis (African clawed frog) 226 76.00% ube2d1 ARP43006_T100 Q6DFK8_XENLA LOC495381 protein (Ube2d2‐prov protein) Xenopus laevis (African clawed frog) 147 92.00% Ubiquitin‐conjugating enzyme E2 D4 ube2d1 ARP43006_T100 B2L4V6_XENBO (Fragment) Xenopus borealis (Kenyan clawed frog) 47 92.00% Xenopus tropicalis (Western clawed frog) ube2d1 ARP43006_T100 B0JYU2_XENTR Putative uncharacterized protein (Fragment) (Silurana tropicalis) 136 92.00% Ubiquitin‐conjugating enzyme E2D 1 (UBC4/5 Xenopus tropicalis (Western clawed frog) ube2d1 ARP43006_T100 A0JM78_XENTR homolog) (Silurana tropicalis) 147 92.00% Ubiquitin‐conjugating enzyme E2 D4 (EC 6.3.2.19) (Ubiquitin carrier protein D4) ube2d1 ARP43006_T100 UB2D4_XENLA (Ubiquitin‐protein ligase D4) Xenopus laevis (African clawed frog) 147 78.00%

Ubiquitin‐conjugating enzyme E2D 2 (UBC4/5 homolog, yeast) (Ubiquitin‐conjugating Xenopus tropicalis (Western clawed frog) ube2d1 ARP43006_T100 Q28EY6_XENTR enzyme E2D 3 (UBC4/5 homolog)) (Silurana tropicalis) 147 78.00% Ubiquitin‐conjugating enzyme E2 D2 (EC 6.3.2.19) (Ubiquitin carrier protein 4) (xUBC4) (Ubiquitin carrier protein D2) (Ubiquitin‐ ube2d1 ARP43006_T100 UB2D2_XENLA protein ligase D2) Xenopus laevis (African clawed frog) 147 78.00% IRF8 ARP32669_T100 Q6DE53_XENLA Icsbp1‐prov protein Xenopus laevis (African clawed frog) 411 100.00% ARP52941_P050 Q5EAV7_XENLA MGC85005 protein Xenopus laevis (African clawed frog) 165 78.00%

Novel protein similar to ovarian carcinoma Xenopus tropicalis (Western clawed frog) ARP52941_P050 Q28G09_XENTR immunoreactive antigen (OCIA) (Silurana tropicalis) 157 78.00% Xenopus tropicalis (Western clawed frog) ARP52941_P050 A9JSR6_XENTR Putative uncharacterized protein (Silurana tropicalis) 99 78.00% Xenopus tropicalis (Western clawed frog) ARP52941_P050 OCAD1_XENTR OCIA domain‐containing protein 1 (Silurana tropicalis) 254 76.00%

Lysosomal‐associated protein transmembrane Xenopus tropicalis (Western clawed frog) LAPTM4B ARP47057_T100 Q6GLF6_XENTR 4 alpha (MGC69213 protein) (Silurana tropicalis) 231 85.00% LAPTM4B ARP47057_T100 Q6GP21_XENLA MGC80735 protein Xenopus laevis (African clawed frog) 231 78.00% LAPTM4B ARP47057_T100 Q5PPZ7_XENLA LOC496032 protein Xenopus laevis (African clawed frog) 231 78.00% Xenopus tropicalis (Western clawed frog) LOC734087 ARP32296_T100 Q0IHN9_XENTR LOC734087 protein (Silurana tropicalis) 355 76.00% LOC734087 ARP32296_T100 B7ZPR5_XENLA XFD‐13 protein Xenopus laevis (African clawed frog) 373 76.00% Xenopus tropicalis (Western clawed frog) LOC734087 ARP32296_T100 A4II85_XENTR Forkhead box F1 (Silurana tropicalis) 373 76.00% Forkhead box protein F1‐B (FoxF1‐B) (FoxF1b) (Fork head domain‐related protein 13') (xFD‐ LOC734087 ARP32296_T100 FXF1B_XENLA 13') Xenopus laevis (African clawed frog) 372 76.00% Forkhead box protein F1‐A (FoxF1‐A) (FoxF1a) (Fork head domain‐related protein 13) (xFD‐ LOC734087 ARP32296_T100 FXF1A_XENLA 13) Xenopus laevis (African clawed frog) 373 76.00% Xenopus tropicalis (Western clawed frog) LOC734087 ARP32296_T100 FOXF1_XENTR Forkhead box protein F1 (FoxF1) (Silurana tropicalis) 373 76.00% Xenopus tropicalis (Western clawed frog) ARP37047_T100 Q0IHN9_XENTR LOC734087 protein (Silurana tropicalis) 355 78.00% ARP37047_T100 B7ZPR5_XENLA XFD‐13 protein Xenopus laevis (African clawed frog) 373 78.00% Xenopus tropicalis (Western clawed frog) ARP37047_T100 A4II85_XENTR Forkhead box F1 (Silurana tropicalis) 373 78.00% Forkhead box protein F1‐B (FoxF1‐B) (FoxF1b) (Fork head domain‐related protein 13') (xFD‐ ARP37047_T100 FXF1B_XENLA 13') Xenopus laevis (African clawed frog) 372 78.00% Forkhead box protein F1‐A (FoxF1‐A) (FoxF1a) (Fork head domain‐related protein 13) (xFD‐ ARP37047_T100 FXF1A_XENLA 13) Xenopus laevis (African clawed frog) 373 78.00% Xenopus tropicalis (Western clawed frog) ARP37047_T100 FOXF1_XENTR Forkhead box protein F1 (FoxF1) (Silurana tropicalis) 373 78.00% RHOBTB1 ARP41883_P050 Q6GPF1_XENLA MGC80424 protein Xenopus laevis (African clawed frog) 691 92.00% Post‐GPI attachment to proteins factor 3 Xenopus tropicalis (Western clawed frog) ARP50189_P050 PGAP3_XENTR (PER1‐like domain‐containing protein 1) (Silurana tropicalis) 316 85.00% Post‐GPI attachment to proteins factor 3 ARP50189_P050 PGAP3_XENLA (PER1‐like domain‐containing protein 1) Xenopus laevis (African clawed frog) 317 85.00%

Lysine‐specific demethylase 3A‐B (EC 1.14.11.‐ ) (JmjC domain‐containing histone demethylation protein 2A) (Jumonji domain‐ Kdm3a ARP32911_T100 KD3AB_XENLA containing protein 1A‐B) Xenopus laevis (African clawed frog) 1334 92.00%

Lysine‐specific demethylase 3A‐A (EC 1.14.11.‐ ) (JmjC domain‐containing histone demethylation protein 2A) (Jumonji domain‐ Kdm3a ARP32911_T100 KD3AA_XENLA containing protein 1A‐A) Xenopus laevis (African clawed frog) 1331 92.00% Ordered Locus Names:MmarC5_0190OrganismMetha nococcus maripaludis (strain C5 / ATCC BAA‐1333) ARP43243_T100 Q7ZX39_XENLA LOC398523 protein (Fragment) Xenopus laevis (African clawed frog) 433 92.00% Ordered Locus Names:MmarC5_0190OrganismMetha nococcus maripaludis (strain C5 / ATCC BAA‐1333) ARP43243_T100 Q6INJ1_XENLA LOC398523 protein (Fragment) Xenopus laevis (African clawed frog) 438 92.00% Ordered Locus Names:MmarC5_0190OrganismMetha nococcus maripaludis (strain C5 / ATCC BAA‐1333) ARP43243_T100 Q641C0_XENLA LOC446971 protein (Fragment) Xenopus laevis (African clawed frog) 448 92.00% Ordered Locus Names:MmarC5_0190OrganismMetha nococcus maripaludis (strain C5 / ATCC BAA‐1333) ARP43243_T100 Q569T8_XENLA Putative uncharacterized protein (Fragment) Xenopus laevis (African clawed frog) 442 92.00% Ordered Locus Names:MmarC5_0190OrganismMetha nococcus maripaludis (strain C5 / ATCC BAA‐1333) ARP43243_T100 Q505M6_XENLA LOC446971 protein (Fragment) Xenopus laevis (African clawed frog) 435 92.00% Ordered Locus Names:MmarC5_0190OrganismMetha nococcus maripaludis (strain C5 / ATCC BAA‐1333) ARP43243_T100 Q2TAW1_XENLA LOC446971 protein Xenopus laevis (African clawed frog) 459 92.00% Ordered Locus Names:MmarC5_0190OrganismMetha nococcus maripaludis (strain C5 / ATCC BAA‐1333) ARP43243_T100 Q2TAU8_XENLA Putative uncharacterized protein (Fragment) Xenopus laevis (African clawed frog) 443 92.00% INSIG1 ARP40159_P050 A1L3F8_XENLA LOC100036994 protein Xenopus laevis (African clawed frog) 248 100.00% Xenopus tropicalis (Western clawed frog) INSIG1 ARP40159_P050 INSI1_XENTR Insulin‐induced gene 1 protein (INSIG‐1) (Silurana tropicalis) 251 100.00% INSIG1 ARP40159_P050 INSI1_XENLA Insulin‐induced gene 1 protein (INSIG‐1) Xenopus laevis (African clawed frog) 251 100.00% Xenopus tropicalis (Western clawed frog) INSIG1 ARP40159_P050 INSI2_XENTR Insulin‐induced gene 2 protein (INSIG‐2) (Silurana tropicalis) 218 85.00% INSIG1 ARP40159_P050 INSI2_XENLA Insulin‐induced gene 2 protein (INSIG‐2) Xenopus laevis (African clawed frog) 218 85.00% Sertad2 ARP51654_P050 Q3KQ22_XENLA MGC131085 protein Xenopus laevis (African clawed frog) 317 85.00% ORF Names:BC1G_08324 EMBL EDN28057.1OrganismBotryotinia fuckeliana (strain B05.10) (Noble rot fungus) (Botrytis cinerea) ARP56460_P050 Q7ZYL1_XENLA Psmb1 protein (Psmb1‐prov protein) Xenopus laevis (African clawed frog) 239 100.00% ORF Names:BC1G_08324 EMBL EDN28057.1OrganismBotryotinia Proteasome (Prosome macropain) subunit fuckeliana (strain B05.10) (Noble rot beta type 1 (Proteasome (Prosome, Xenopus tropicalis (Western clawed frog) fungus) (Botrytis cinerea) ARP56460_P050 Q6P8E4_XENTR macropain) subunit, beta type, 1) (Silurana tropicalis) 239 100.00%

Ordered Locus Names:Bcen2424_0812OrganismBurkh olderia cenocepacia (strain HI2424) ARP48267_T100 Q7SYT1_XENLA Prdx6‐prov protein Xenopus laevis (African clawed frog) 224 100.00%

Ordered Locus Names:Bcen2424_0812OrganismBurkh olderia cenocepacia (strain HI2424) ARP48267_T100 Q7SYQ4_XENLA MGC64582 protein Xenopus laevis (African clawed frog) 224 100.00%

Ordered Locus Names:Bcen2424_0812OrganismBurkh Peroxiredoxin 6 (Putative uncharacterized Xenopus tropicalis (Western clawed frog) olderia cenocepacia (strain HI2424) ARP48267_T100 Q6P624_XENTR protein MGC76137) (Silurana tropicalis) 224 100.00%

Ordered Locus Names:Bcen2424_0812OrganismBurkh Xenopus tropicalis (Western clawed frog) olderia cenocepacia (strain HI2424) ARP48267_T100 Q5M8E1_XENTR Peroxiredoxin 6 (Silurana tropicalis) 219 100.00%

Ordered Locus Names:Bcen2424_0812OrganismBurkh Xenopus tropicalis (Western clawed frog) olderia cenocepacia (strain HI2424) ARP48267_T100 B5DFS7_XENTR MGC76137 protein (Fragment) (Silurana tropicalis) 213 100.00% LOC100036879 ARP34747_P050 D0VPT3_XENLA EGL nine homolog 2 Xenopus laevis (African clawed frog) 454 92.00% LOC100036879 ARP34747_P050 B0JZW2_XENLA LOC100158265 protein (Fragment) Xenopus laevis (African clawed frog) 263 92.00% Xenopus tropicalis (Western clawed frog) LOC100036879 ARP34747_P050 B1H3D4_XENTR LOC100145602 protein (Silurana tropicalis) 252 92.00% LOC100127282 protein (Putative LOC100036879 ARP34747_P050 A9JS11_XENLA uncharacterized protein LOC100127282) Xenopus laevis (African clawed frog) 252 92.00% LOC100036879 ARP34747_P050 A1L2K9_XENLA LOC100036879 protein Xenopus laevis (African clawed frog) 252 92.00% LOC100036879 ARP34747_P050 Q6DFD1_XENLA Egln2‐prov protein Xenopus laevis (African clawed frog) 408 92.00% EGL nine homolog 2 (C. elegans) (Egl nine Xenopus tropicalis (Western clawed frog) LOC100036879 ARP34747_P050 Q28E59_XENTR homolog 1 (C. elegans)) (Silurana tropicalis) 394 92.00% ORF Names:zgc:162183 EMBL AAI39537.1 ZFIN ZDB‐GENE‐070410‐ 30OrganismDanio rerio (Zebrafish) Putative uncharacterized protein LOC548951 Xenopus tropicalis (Western clawed frog) (Brachydanio rerio) ARP58524_P050 Q28CJ3_XENTR (Sterile alpha motif domain containing 8) (Silurana tropicalis) 412 100.00% Gys1 ARP45727_P050 Q6NRR2_XENLA MGC82298 protein Xenopus laevis (African clawed frog) 702 85.00% Xenopus tropicalis (Western clawed frog) Gys1 ARP45727_P050 Q5FVV6_XENTR MGC108445 protein (Silurana tropicalis) 703 85.00%

ORF Names:v1g119733OrganismNematostel la vectensis (Starlet sea anemone) ARP47649_P050 P79939_XENLA XMeis1‐3 protein (Fragment) Xenopus laevis (African clawed frog) 137 100.00%

ORF Names:v1g119733OrganismNematostel la vectensis (Starlet sea anemone) ARP47649_P050 B7ZRS8_XENLA Meis1 protein Xenopus laevis (African clawed frog) 465 100.00%

ORF Names:v1g119733OrganismNematostel Xenopus tropicalis (Western clawed frog) la vectensis (Starlet sea anemone) ARP47649_P050 A0JPD2_XENTR Meis2 protein (Silurana tropicalis) 368 100.00%

ORF Names:v1g119733OrganismNematostel la vectensis (Starlet sea anemone) ARP47649_P050 MEIS1_XENLA Isoform 2 (Isoform XMeis1‐2) (Isoform b) Xenopus laevis (African clawed frog) 465 100.00%

ORF Names:v1g119733OrganismNematostel la vectensis (Starlet sea anemone) ARP47649_P050 MEI3A_XENLA Isoform 2 Xenopus laevis (African clawed frog) 385 100.00%

ORF Names:v1g119733OrganismNematostel Xenopus tropicalis (Western clawed frog) la vectensis (Starlet sea anemone) ARP47649_P050 MEIS3_XENTR Homeobox protein meis3 (Silurana tropicalis) 453 100.00%

ORF Names:v1g119733OrganismNematostel la vectensis (Starlet sea anemone) ARP47649_P050 MEIS1_XENLA Homeobox protein Meis1 (XMeis1) Xenopus laevis (African clawed frog) 390 100.00% ORF Names:v1g119733OrganismNematostel la vectensis (Starlet sea anemone) ARP47649_P050 MEI3B_XENLA Homeobox protein meis3‐B Xenopus laevis (African clawed frog) 451 100.00%

ORF Names:v1g119733OrganismNematostel la vectensis (Starlet sea anemone) ARP47649_P050 MEI3A_XENLA Homeobox protein meis3‐A (XMeis3) Xenopus laevis (African clawed frog) 453 100.00% Xenopus tropicalis (Western clawed frog) CH211‐156J16.2 ARP55677_P050 B1H339_XENTR LOC100145548 protein (Silurana tropicalis) 315 92.00%

ORF Names:MGG_03974 EMBL EDJ99262.1OrganismMagnaporthe oryzae (strain 70‐15 / FGSC 8958) (Rice blast fungus) (Pyricularia oryzae) ARP44050_P050 Q5PQ46_XENLA LOC495984 protein Xenopus laevis (African clawed frog) 318 100.00%

ORF Names:MGG_03974 EMBL EDJ99262.1OrganismMagnaporthe oryzae (strain 70‐15 / FGSC 8958) (Rice Xenopus tropicalis (Western clawed frog) blast fungus) (Pyricularia oryzae) ARP44050_P050 Q0VFE5_XENTR Slc25a32 protein (Fragment) (Silurana tropicalis) 325 100.00%

ORF Names:MGG_03974 EMBL EDJ99262.1OrganismMagnaporthe oryzae (strain 70‐15 / FGSC 8958) (Rice Xenopus tropicalis (Western clawed frog) blast fungus) (Pyricularia oryzae) ARP44050_P050 A9ULD2_XENTR Slc25a32 protein (Silurana tropicalis) 322 100.00% Upstream transcription factor 2, c‐fos Xenopus tropicalis (Western clawed frog) Usf2 ARP33482_P050 Q68F85_XENTR interacting (Silurana tropicalis) 312 92.00% Usf2 ARP33482_P050 Q5XKA1_XENLA LOC494839 protein Xenopus laevis (African clawed frog) 310 92.00% Usf2 ARP33482_P050 Q5PQ69_XENLA LOC495964 protein Xenopus laevis (African clawed frog) 310 92.00% ARP31676_T100 Q6GPM9_XENLA LOC443625 protein (Fragment) Xenopus laevis (African clawed frog) 514 78.00% Xenopus tropicalis (Western clawed frog) ikzf2 ARP31676_T100 B1H2P4_XENTR Ikzf2 protein (Silurana tropicalis) 523 78.00% Xenopus tropicalis (Western clawed frog) nono ARP40571_T100 B3DM42_XENTR Putative uncharacterized protein (Fragment) (Silurana tropicalis) 551 92.00% Xenopus tropicalis (Western clawed frog) nono ARP40571_T100 B2GU75_XENTR LOC100158518 protein (Silurana tropicalis) 659 92.00% nono ARP40571_T100 Q7ZX79_XENLA p54nrb protein Xenopus laevis (African clawed frog) 464 83.00%

Non‐POU domain containing, octamer‐binding Xenopus tropicalis (Western clawed frog) nono ARP40571_T100 Q6NZH7_XENTR (Putative uncharacterized protein MGC75848) (Silurana tropicalis) 465 83.00% nono ARP40571_T100 Q2V0J2_XENLA 54 kD nuclear RNA‐binding protein Xenopus laevis (African clawed frog) 463 83.00% ORF Names:ACLA_036650 EMBL EAW09460.1OrganismAspergillus clavatus ARP54787_P050 Q640H5_XENLA Isocitrate dehydrogenase [NADP] (EC 1.1.1.42) Xenopus laevis (African clawed frog) 415 100.00% Xenopus tropicalis (Western clawed frog) ARP47463_P050 Q6P7K6_XENTR Keratin 19 (Silurana tropicalis) 412 85.00% Xenopus tropicalis (Western clawed frog) ARP47463_P050 Q28FN7_XENTR Keratin 19 (Silurana tropicalis) 307 85.00% ARP47463_P050 Q05AX6_XENLA Krt19 protein Xenopus laevis (African clawed frog) 443 84.00% ARP47463_P050 Q5XGU0_XENLA LOC495266 protein Xenopus laevis (African clawed frog) 452 78.00% ARP47463_P050 Q6IRP5_XENLA MGC83069 protein Xenopus laevis (African clawed frog) 412 76.00% ORF Names:BC1G_13593 EMBL EDN19744.1OrganismBotryotinia fuckeliana (strain B05.10) (Noble rot Calcium‐responsive transactivator (ss18‐like fungus) (Botrytis cinerea) ARP55923_P050 CREST_XENLA protein 1) Xenopus laevis (African clawed frog) 403 84.00% Xenopus tropicalis (Western clawed frog) NOXO1 ARP53762_P050 B0BMD4_XENTR LOC100145021 protein (Silurana tropicalis) 213 100.00% ORF Names:CBG18123 WormBase CBG18123, CBG_18123 EMBL CAP35631.1OrganismCaenorhabditis briggsae ARP54798_P050 Q7ZXN2_XENLA Lasp1 protein Xenopus laevis (African clawed frog) 256 92.00% ORF Names:CBG18123 WormBase CBG18123, CBG_18123 EMBL CAP35631.1OrganismCaenorhabditis Xenopus tropicalis (Western clawed frog) briggsae ARP54798_P050 Q66KD2_XENTR LIM and SH3 protein 1 (Lasp1 protein) (Silurana tropicalis) 258 92.00% ORF Names:CBG18123 WormBase CBG18123, CBG_18123 EMBL CAP35631.1OrganismCaenorhabditis briggsae ARP54798_P050 Q5XGQ5_XENLA LOC495167 protein Xenopus laevis (African clawed frog) 275 78.00% Xenopus tropicalis (Western clawed frog) ARP48288_P050 A4IH81_XENTR LOC100124811 protein (Silurana tropicalis) 172 100.00% Cytoplasmic myosin II regulatory light chain ARP48288_P050 Q91625_XENLA (Mrlcb protein) Xenopus laevis (African clawed frog) 172 92.00% Xenopus tropicalis (Western clawed frog) ARP48288_P050 Q6GLB7_XENTR MGC69457 protein (Silurana tropicalis) 172 92.00% ARP48288_P050 Q6DCU1_XENLA MGC80742 protein Xenopus laevis (African clawed frog) 172 92.00% ARP48288_P050 Q641H1_XENLA MGC81583 protein Xenopus laevis (African clawed frog) 172 92.00% MGC69457 protein (Myosin regulatory light Xenopus tropicalis (Western clawed frog) ARP48288_P050 Q28IZ4_XENTR chain MRLC2) (Silurana tropicalis) 172 92.00% Xenopus tropicalis (Western clawed frog) ARP48233_P050 SBP1_XENTR Selenium‐binding protein 1 (Silurana tropicalis) 472 78.00% loxl1 ARP54781_P050 Q52KW2_XENLA LOC733215 protein (Fragment) Xenopus laevis (African clawed frog) 351 92.00% loxl1 ARP54781_P050 Q5M7F9_XENLA Lysyl oxidase‐like 1 (Oxl‐1 protein) Xenopus laevis (African clawed frog) 527 85.00% Xenopus tropicalis (Western clawed frog) loxl1 ARP54781_P050 A4IHQ3_XENTR LOC100124878 protein (Silurana tropicalis) 525 85.00%

Probable UDP‐sugar transporter protein SLC35A5 ARP43979_P050 S35A5_XENLA SLC35A5 (Solute carrier family 35 member A5) Xenopus laevis (African clawed frog) 413 76.00% Xenopus tropicalis (Western clawed frog) ARP37395_T100 A9UM39_XENTR Foxp4 protein (Silurana tropicalis) 645 76.00% foxp4 ARP37395_T100 FOXP4_XENLA Forkhead box protein P4 (XlFoxP4) Xenopus laevis (African clawed frog) 641 76.00% ARP35179_P050 Q6GR11_XENLA MGC81430 protein Xenopus laevis (African clawed frog) 283 100.00% Xenopus tropicalis (Western clawed frog) ARP35179_P050 Q5M8U0_XENTR Voltage‐dependent anion channel 3 (Silurana tropicalis) 283 100.00% ORF Names:M23134_02781 EMBL EAY25311.1OrganismMicroscilla marina Xenopus tropicalis (Western clawed frog) ATCC 23134 ARP44044_T100 B4F6P8_XENTR Putative uncharacterized protein (Silurana tropicalis) 473 78.00% Zinc finger protein ZIC 4 (XlZic4) (Zinc finger ZIC1 ARP39681_P050 ZIC4_XENLA protein of the cerebellum 4) Xenopus laevis (African clawed frog) 530 100.00% Zinc finger protein ZIC 3 (Zinc finger protein of Xenopus tropicalis (Western clawed frog) ZIC1 ARP39681_P050 ZIC3_XENTR the cerebellum 3) (Silurana tropicalis) 441 100.00% Zinc finger protein ZIC 3 (XZic3) (XlZic3) (Zinc finger protein Zic3‐A) (Zinc finger protein of ZIC1 ARP39681_P050 ZIC3_XENLA the cerebellum 3) Xenopus laevis (African clawed frog) 441 100.00%

Zinc finger protein ZIC 2‐B (Zic‐related‐2) (ZIC‐ ZIC1 ARP39681_P050 ZIC2B_XENLA R2) (Zinc finger protein of the cerebellum 2‐B) Xenopus laevis (African clawed frog) 497 100.00% Zinc finger protein ZIC 2‐A (Zinc finger DNA‐ binding protein fZic) (Zinc finger protein ZIC 2) (XlZic2) (xZic2) (Zinc finger protein of the ZIC1 ARP39681_P050 ZIC2A_XENLA cerebellum 2‐A) Xenopus laevis (African clawed frog) 503 100.00%

Zinc finger protein ZIC 1 (XZic1) (XlZic1) (ODD‐ paired‐like) (Xopl) (ZIC‐related protein 1) (ZIC‐ ZIC1 ARP39681_P050 ZIC1_XENLA r1) (Zinc finger protein of the cerebellum 1) Xenopus laevis (African clawed frog) 443 100.00% ZIC1 ARP39681_P050 B7ZPU8_XENLA Zic family member 5 Xenopus laevis (African clawed frog) 515 92.00% Zinc finger protein ZIC 5 (XZic5) (XlZic5) (Zinc ZIC1 ARP39681_P050 ZIC5_XENLA finger protein of the cerebellum 5) Xenopus laevis (African clawed frog) 515 92.00% Gli‐Kruppel zinc‐finger protein NKL isoform b ZIC1 ARP39681_P050 Q98T93_XENLA (Fragment) Xenopus laevis (African clawed frog) 478 78.00% Zinc finger protein GLIS2 (GLI‐similar 2) ZIC1 ARP39681_P050 GLIS2_XENLA (Neuronal Krueppel‐like protein) Xenopus laevis (African clawed frog) 492 78.00% ZIC1 ARP39681_P050 Q9W6B2_XENLA Zinc finger protein Gli2 Xenopus laevis (African clawed frog) 1354 80.00% ORF Names:GSPATT00017608001 EMBL CAK83264.1OrganismParamecium tetraurelia ARP48974_P050 Q6DDS6_XENLA Alg2‐prov protein Xenopus laevis (African clawed frog) 404 92.00% ORF Names:GSPATT00017608001 EMBL CAK83264.1OrganismParamecium Xenopus tropicalis (Western clawed frog) tetraurelia ARP48974_P050 Q56A17_XENTR Asparagine‐linked glycosylation 2 homolog (Silurana tropicalis) 404 92.00% ORF Names:GSPATT00017608001 EMBL CAK83264.1OrganismParamecium Xenopus tropicalis (Western clawed frog) tetraurelia ARP48974_P050 B1H2B6_XENTR LOC100145379 protein (Silurana tropicalis) 402 92.00%