The Henry Kunkel Society Annual Meeting: Human Immunology in Health and Disease

The Rockefeller University New York, NY April 3–5, 2014 Doruk Erkan Adrian Hill Lloyd Mayer Marko Z. Radic Yoshinari Takasaki Henry George Kunkel Luis R. Espinoza Jules Hirsch Maclyn McCarty# Kanti R. Rai Toshitada Takemori Paul Evans Richard J. Hodes James McCluskey Klaus Rajewsky Norman Talal 1916–1983 Zsuzsa Fabry V. Michael Holers Joseph (Mike) McCune Joyce Rauch Eng M. Tan Andras Falus Steven M. Holland A. McGehee Harvey Jeffrey Ravetch Stuart Tangye Donna L. Farber Halsted R. Holman Victor McKusick Stanley Read Alexander Tarakhovsky A. Darise Farris David Horn Ruslan Medzhitov Ann Reed Kristin Tarbell enry Kunkel received his B.S. degree from Princeton and his M.D. degree from Johns Hopkins University. C. Garrison Fathman Alan N. Houghton Eric Meffre Westley H. Reeves Naomi Taylor He arrived at The Rockefeller Institute (now University) in 1945 where he spent his entire scientific career Douglas Thomas Fearon Thomas W. J. Huizinga Fritz Melchers Morris Reichlin Francesco Tedesco Ten Feizi Mary Beth Humphrey Elizabeth D. Mellins Bernardo Reina- Cox Terhorst Huntil his death in 1983. His contributions to the field of basic and clinical immunology are legendary. He Marc Feldmann John Hurley# Henri Menard San Martin Argyrios N. Theofilopoulos made numerous seminal observations in liver disease, rheumatic diseases and other allied disorders. Gianfranco Ferraccioli David A. Isenberg Miriam Merad Maria Rescigno Robert Thoburn Manlio Ferrarini Kimishige Ishizaka Pier Luigi Meroni Michael Reth Adrian Thrasher Erol Fikrig Lionel B. Ivashkiv Joan T. Merrill Lisa G. Rider Angela Tincani He was perhaps best known for his pioneering and extensive studies on the immunoglobulins. His recognition that Terri Finkel Bana Jabri Jiri Mestecky Frederic Rieux-Laucat Thomas Tomasi Alison Finnegan Hans-Martin Jäck Christine Metz William C. Robbins Kevin J. Tracey myeloma proteins were a model for the study of the structure of normal immunoglobulins had a global impact on Gary S. Firestein Chaim Oscar Jacob Dror Mevorach William Robinson Elisabetta Traggiai investigations of the structure, function and inheritance of these molecules. The elucidation of the chain structure of Vincent Fischetti Israeli Jaffe Mary Ann Michelis Toby Rodman Edward L. Treadwell gamma globulin and the recognition that immunoglobulins possessed individual antigenic specificity (idiotypes) were Zvi Fishelson Ashish Jain Peter A. Miescher Martin Rodriguez Giorgio Trinchieri David E. Fisher Judith A. James Fred Miller Santiago Rodriguez Jurg Tschopp# internationally recognized discoveries. Richard A. Flavell Roland Jonsson Eric C. B. Milner de Cordoba George Tsokos Thomas A Fleisher Dieter Kabelitz Joshua Milner† Axel Roers Naoyuki Tsuchiya Francesco Forconi† Joachim R. Kalden Toshihide Mimura Christopher Roman Shannon Turley Dr. Kunkel was the recipient of many awards and honors, including membership in the National Academy of Ira J. Fox Insoo Kang Seiji Minota Lars Rönnblom Kenneth Tyler† Sciences, honorary degrees from Universities of Uppsala and Harvard, and recipient of the Lasker and Gairdner Marvin Fritzler Gilla Kaplan Pierre Miossec Antony Rosen Antonio Uccelli Awards and the Kovalenko Medal of the National Academy of Sciences. Yang-Xin Fu Fu Mikael Karlsson Chandra Mohan Fred Rosen# Jonathan W. Uhr Shu Man Fu Jonathan D. Katz Tom Eirik Mollnes Hugh Rosen† Raivo Uibo Herman Fudenberg Michel D. Kazatchkine Patricia K. A. Mongini Agueda A. Rostagno Emil R. Unanue Sarah L. Gaffen Jack D. Keene Laurence Morel Thomas Rothstein Derya Unutmaz Patrick Gaffney Robert Kimberly Lorenzo Moretta Robert A. S. Roubey Jacques Urbain Henry Kunkel Society Officers Henry Kunkel Society Lecturers Gianluca Gaidano Paul W. Kincade Jane Morse# Robert L. Rubin Paul J. Utz President ...... Keith Elkon 1992...... Louis Kunkel 2004...... Diane Mathis Thomas F. Gajewski Thomas Kindt Bernard Moser Alexander Y. Rudensky Anders G. Vahlne Uri Galili Te Piao King William A. Muller Carlo Russo Andrea Vambutas Vice President. . . .Jean-Laurent Casanova 1993...... David Ho 2005...... Charles Weissman # Secretary ...... Michel Nussenzweig 1994...... Benvenuto Pernis 2006...... Ralph M. Steinman Ignacio Garcia- Michael Kirschfink Hans Muller-Eberhard Federica Sallusto Wesley C. Van Voorhis Treasurer...... Anne Marshak- 1996...... Jeffrey Ravetch 2007...... Antonio Lanzavecchia De La Torre Lars Klareskog Kenneth Murphy Jane E. Salmon Charles S. Via Hubert Baburaj (Bobby) Kim L. Kline Philip M. Murphy Hugh A. Sampson Anna Villa Rothstein 1997...... Anthony Fauci 2008...... John Atkinson Gasper Glen Knight Natarajan Muthusamy Inger Sandlie Herbert W. Virgin 1998...... Klaus Rajewsky 2009...... Thomas Tuschl Raif S. Geha Daniel M. Knowles Bertrand Nadel Matyas Sandor Ulrich H. Freiherr 1999...... Peter Doherty 2010...... Frederick Alt James L. German, III Hon-Sum Ko Carl F. Nathan Laura Santambrogio von Andrian-Werburg 2000...... Max D. Cooper 2011...... Mark M. Davis M. Eric Gershwin Alisa E. Koch Jacob B. Natvig Ignacio Sanz Harald von Boehmer 2001...... Fritz Melchers 2012...... Louis M. Staudt Paolo Ghia David Koffler# Gerald Thomas Nepom Minoru Satoh Takaji Wakita 2002...... Tasuku Honjo 2013 ...... Daniel L. Kastner Allan Gibofsky Frits Koning Janko Nikolich-Zugich David Schatz Thomas A. Waldmann 2003...... Fred Rosen Irma Gigli Dwight H. Kono Kenneth Nilsson Georg Schett Herman Waldmann Gray Steven Gilkeson Philippe H. A. Kourilsky Falk Nimmerjahn Claudine Schiff Mark Jeremy Walport Martin John Glennie Michael Krangel Douglas F. Nixon Reinhold Schmidt Chang-Yi Wang Laurie Glimcher Richard Krause Gustav J. V. Nossal Robert Schreiber Jingsong Wang Henry Kunkel Society Members Otto Goetze Karsten Kretschmer Luigi D. Notarangelo Harry W. Schroeder, Jr. H. Shaw Warren Leslie Gold James G. Krueger Jan Novak Peter H. Schur Richard L. Wasserman Gyorgy Abel Robert D. Bigler, II Rafael Casellas Charlotte Cunningham- Raphaela Goldbach- Vijay Kuchroo Victor Nussenzweig Hans-Wilhelm Schwaeble† Martin Weigert Sergio Abrignani Richard S. Blumberg Michael Centola Rundles Mansky Dinakantha Kumararatne Michel C. Nussenzweig R. Hal Scofield Jean-Claude Weill Luciano Adorini Linda K. Bockenstedt Anthony Cerami Riccardo Dalla-Favera Robert A. Good# Steven Kunkel Hans D. Ochs Gavin Screaton Marc Weksler Vincent Agnello Bjarne Bogen Andrea Cerutti Rajendra Damle Tom Gordon Louis Kunkel Lloyd Old Benjamin M. Segal Hans Ulrich Weltzien Irma Airold Gilles Boire† Ethel Cesarman Franco Dammacco Siamon Gordon Antonio La Cava Michael B. A. Oldstone Andrey Shaw Peter P. Wernet Arne N. Akbar Catherine Bollard† Edward K. L. Chan Robert B. Darnell Jorg J. Goronzy Peter J. Lachmann Eugene Oltz Barbaray Sherry Per Westermark Donato Alarcon-Segovia# Stefano Bombardieri Andrew Chan Anne Davidson Emil C. Gotschlich Robert G. Lahita Jordan Scott Orange Yufang Shi Cornelia M. Weyand Matthew Albert Constantin A. Bona George K. Chandy Randall S. Davis Susan R. S. Gottesman Antonio Lanzavecchia Anders Orn Mark Jay Shlomchik Juergen Wienands Mara Luisa (Marisa) Alegre Jerry Boss Lucienne Chatenoud Noorbibi K. Day Alice B. Gottlieb Terri Laufer Barbara Anne Osborne Frederick P. Siegal David Wiest Konstantina Alexandropoulos Marina Botto Talal Chatila Jean-Michel Dayer Ellen M. Gravallese Jeffery A. Ledbetter C. Kirk Osterland Leslie E. Silberstein Ralph C. Williams, Jr. Paul Allen Vassiliki A. Boussiotis Triantafyllos Chavakis Silvia Deaglio Arthur Grayzel David M. Lee Mario A. Ostrowski Gregg Silverman Patrick C. Wilson Chester A. Alper Jean-Pierre Bouvet Youhai Chen Paolo Dellabona Mark Grebenau Paul J. Lehner Shoichi Ozaki Roy L. Silverstein Robert J. Winchester Sebastian Amigorena Joseph Boyle Selina Chen-Kiang Stephen V. Desiderio Mark I. Greene Michael J. Lenardo† Stephen A. Paget Franco Silvestris John Winfield Ulf Anderson Thomas J. Braciale Nicholas Chiorazzi Kavita Dhodapkar Howard M. Grey Beth Levine Savita Pahwa Alfred Singer Jedd Wolchok Paul J. Anderson Ferdinand C. Breedveld Francis V. Chisari Madhav V. Dhodapkar Bodo Grimbacher Peter Lipsky Eric G. Pamer Ram Singh Kevin Woollard Francesco Annuziato Michael Brenner Carlo Chizzolini Betty A. Diamond Luca Guidotti Sergio A. Lira Sunpho Park Francesco Sinigaglia Kai W. Wucherpfennig William P. Arend Stanley Louis Bridges Charles Christian Howard Dickler Sudhir Gupta Gary W. Litman Virginia Pascual John Patrick Sissons Ramnik Xavier Joseph R. Arron Thomas Brocker Charles Chu Guillermo Dighiero David A. Hafler Stephen Litwin Dhavalkumar D. Patel Marjorie Slankard Kazuhiko Yamamoto John P. Atkinson Eric Brown Marcus Ramsay Clark Teresa P. DiLorenzo Kathleen A. Haines Yang Liu Andras Perl Barry Sleckman William Yount K. Frank Austen Teodor-Boru Brumeanu Edward A. Clark Walter H. Doerfler William W. Hall Miguel Lopez-Botet Peter Perlmann Kendall Smith John Zabriskie Stratis Avrameas Steven Burakoff† Rachael Clark† Peter C. Doherty Sophie Hambleton† Pier Luigi Luigi Meroni Benvenuto Pernis Kenneth G. C. Smith Debra Jeske Zack Raffaele Badolato Gerd-Rudiger Burmester Charles Cochrane Thomas Dörner Lennart Hammarstrom† Xiaojing Ma Erik Peterson Josef Smolen Habib Zaghouani David Bahler Joel Buxbaum Michel Cogné † Daniel Douek Lars Hanson Crystal L. Mackall Rodney Ernest Phillips Scott Snapper Jianying Zhang Vincenzo Barnaba Jill Buyon Richard Coico Steven Douglas Morten Harboe Ravinder N. Maini Richard Phipps Eric Sobel Maurizio Zanetti Craig Bassing Edit Buzás† Mary Ellen Conley Terry William Du Clos John A. Hardin Fabio Malavasi Matthew Pickering Ludvig M. Sollid Pan Zheng Antony Basten John C. Byrd Gabriela Constantin Anne Durandy David M. Harlan Mark J. Mamula David S. Pisetsky Alan Solomon Song Guo Zheng Ekkehard K. F. Bautz Michael Cahalan H. Terence Cook George Ebers John B. Harley Mart Mannik Vito Pistoia Silvano Sozzani Rolf Zinkernagel Alexander Bearn# Federico Caligaris-Cappio David Cooper Dimitar G. Efremov Jeffrey Hasday Alberto Mantovani K. Michael Pollard David Spaner† Yong-Rui Zou Timothy W. Behrens Michael P. Cancro Max D. Cooper Michael Ehrenstein Dorian Haskard Markus G. Manz Richard M. Pope Kostas Stamatopoulos Moncef Zouali Baruj Benacerraf# Daniela Capello Andrew P. Cope Götz Ehrhardt Barton Haynes John J. Marchalonis David N. Posnett Louis Staudt Juan Carlos Zuniga- J. Claude Bennett J. Donald Capra Joseph Craft Klaus Eichmann Peter Henson Francesco M. Marincola Robert Prendergast Bettie M. Steinberg Pflucker Christophe O. Benoist Ronald I. Carr Carlo M. Croce Robert A. Eisenberg Kevan C. Herold Joseph A. Markenson Luminita Pricop Ralph M. Steinman# Zvi Bentwich Michael C. Carroll Alan Cross Hani El-Gabalawy Rafael Herrera-Esparza Ann Marshak-Rothstein Jennifer Puck† Freda K. Stevenson Claudia Berek Robert H. Carter Mary K. Crow Keith Elkon Martin Herrmann Ana Martinez Chaim Putterman Joseph St. Geme III† Kâre Berg Paolo Casali Yanick Crow† Anna Erdei Ingrid Birgitta Heyman Giuseppe Matarese Lluis Quintana-Murci† William Stohl † New member Ira Berkower Jean-Laurent Casanova Falk Hiepe Diane J. Mathis Andreas Radbruch Kathleen Sullivan # Deceased PROGRAM 10:05 a.m. Arne N. Akbar (Member) University College London, London, UK Early Defects in Cutaneous Immune Responses to Varicella Zoster Virus Challenge in Old THURSDAY, APRIL 3, 2014 Individuals 10:25 a.m. Coffee break 4 p.m. Council Meeting Cohn Library (Refreshments will be served) 10:50 a.m.–12:25 p.m. Session II: Inflammation and Human Disease Co-Chairs: Mary K. Crow and Gerald Nepom 4:30 p.m. Meeting Registration CRC Lower Level 10:50 a.m. Virginia Pascual (Invited Speaker) (outside of Carson Family Baylor Institute for Immunology Research, Dallas, TX, USA Auditorium) Human Systemic Lupus Erythematosus (SLE)

6 p.m. Annual Henry Kunkel Society Lecture 11:15 a.m. Anthony Segal (Invited Speaker) Carson Family Auditorium Shigekazu Nagata University College London, London, UK Professor, Department of Medical Chemistry Crohn’s is an Immunodeficiency Disease Kyoto University, Kyoto, Japan Apoptosis and Engulfment of Dead Cells 11:40 a.m. Richard Phipps (Member) University of Rochester Medical Center, Rochester, NY, USA † 7 p.m. Cocktail Reception Specialized Proresolving Lipid Mediators Enhance Antibody Responses: A New Class CRC Lower Level of Adjuvant? (outside of Carson Family Auditorium) 12:05 p.m. Joshua Milner (New Member) National Institute of Allergy and Infectious Diseases, Bethesda, MD, USA † Cocktails tickets must be purchased in advance. Insights into Allergic Pathways from the Discovery and Study of Congenital Diseases of Atopy FRIDAY, APRIL 4, 2014 12:25 p.m. Lunch (HKS Member Lunch will be held in the Cohn Library) 7:15 a.m.–8:00 a.m. Continental Breakfast CRC Lower Level 1:30 p.m.–3 p.m. Session III: Host-Pathogen Interactions (outside of Carson Family Co-Chairs: Douglas F. Nixon and Lewis Lanier Auditorium) 1:30 p.m. Lewis Lanier (Invited Speaker) 8 a.m. Welcoming Remarks University of California, San Francisco, CA, USA Carson Family Auditorium Keith Elkon Human Natural Killer Cell Responses to Herpesviruses President, The Henry Kunkel Society University of Washington, Seattle, WA, USA 1:55 p.m. Michel Nussenzweig (Invited Speaker) The Rockefeller University, New York, NY, USA 8:25 a.m.–10:25 a.m. Session I: Tissue Immunity Neutralizing Antibodies Against HIV Co-Chairs: Ann Marshak-Rothstein and Westley Reeves 2:20 p.m. Kenneth Tyler (New Member) 8:25 a.m. Marco Colonna (Invited Speaker) University of Colorado School of Medicine, Denver, Aurora, CO, USA Washington University School of Medicine, St. Louis, MO, USA Experimental Approaches for Studying Pathogenesis of Viral CNS Infections Innate Lymphoid Cells in Mucosal Immunity 2:40 p.m. Eric J. Allenspach (Non-Member Selected Speaker) 8:50 a.m. Jay Kolls (Invited Speaker) University of Washington and Seattle Children’s Research Institute, Seattle, WA, USA University of Pittsburgh School of Medicine, Pittsburgh, PA, USA Human Intrauterine Fetal Autoimmunity Occurring with Defective Fetal Regulatory Pulmonary T Cells T Cells

9:15 a.m. Philippe Gros (Invited Speaker) 3 p.m. Break McGill University, Montreal, Canada Gene Discovery in Neuroinflammation 3:50 p.m.–5 p.m. Session IV: New Frontiers Co-Chairs: J. Donald Capra and Mark Davis 9:40 a.m. Bana Jabri (Invited Speaker) The University of Chicago, Chicago, IL, USA 3:50 p.m. Lluis Quintana-Murci (Invited Speaker/New Member) Tissue Immunity and IL-15 Institut Pasteur, Paris, France Population Genetic Tools for Dissecting Human Immunology 4:15 p.m. Mark Davis (Invited Speaker) 11:20 a.m.–12:20 p.m. Session VII: Immunotherapy Stanford University School of Medicine, Stanford, CA, USA Co-Chairs: Jane E. Salmon and Mikael Karlsson Systems Immunology — Progress and Prospects 11:20 a.m. David Spaner (New Member) University of Toronto, Toronto, ON 4:40 p.m. Yuval Itan (Non-Member Selected Speaker) A Candidate Lipid Inhibitor of Toll-like Receptor Signaling in Leukemia The Rockefeller University, New York, NY, USA Cohort-wide Automated Identification of Morbid Alleles with the Human Gene Connectome 11:40 a.m. Edit Buzás (New Member) Semmelweis University, Budapest, Hungary 6:00 p.m. Dinner† Extracellular Vesicles in Inflammation Morso Restaurant 420 E. 59th Street (between York Ave & First Ave.) 12 p.m. Hugh Rosen (New Member) †Dinner tickets must be purchased in advance. The Scripps Research Institute, La Jolla, CA, USA From R01 to Phase 3: Mechanisms and Molecules in S1P Receptor Therapeutics

SATURDAY, APRIL 5, 2014 12:20 p.m. Final Meeting Announcements 12:40 p.m. Postdoctoral Fellow/Junior Faculty Lunch with HKS Investigators† 7:15 a.m.–8:00 a.m. Continental Breakfast Cohn Library CRC Lower Level (outside of Carson Family †Registration required. Auditorium)

8 a.m.–9:30 a.m. Session V: Lymphocyte Biology Carson Family Auditorium Co-Chairs: Edward A. Clark and Michael P. Cancro

8 a.m. Jean-Claude Weill (Invited Speaker) INSERM, Paris, France Human Marginal Zone B Cells

8:25 a.m. Yenan Bryceson (Invited Speaker) Karolinska Institutet, Stockholm, Sweden Regulation of Lymphocyte Cytotoxicity

8:50 a.m. Michel Cogné (New Member) Limoges University, CNRS, Limoges, France B Cells Switching to Deadly Paths

9:10 a.m. Francesco Forconi (New Member) University of Southampton, Southampton, UK Intraclonal Variability in B-cell Receptor Function Reveals Potentially Dangerous but Targetable Cells within Cases of Chronic Lymphocytic Leukemia

9:30 a.m. Break

9:50 a.m.–11:20 a.m. Session VI: Immune Cell Subsets Co-Chairs: Thomas Brocker and Edit Buzás

9:50 a.m. Federica Sallusto (Invited Speaker) Institute for Research in Biomedicine, Bellinzona, Switzerland Class and Specificity of the Human T Cell Response in Health and Disease

10:15 a.m. Yong-Jun Liu (Invited Speaker) Baylor Institute for Immunology Research Dallas, TX, USA Human Dendritic Cells 10:40 a.m. Rachael Clark (New Member) Harvard Medical School, Boston, MA, USA Human Tissue Resident T Cells: Immunity When and Where You Need It

11 a.m. Sun Jung Kim (Non-Member Selected Speaker) The Feinstein Institute for Medical Research, Manhasset, NY, USA Role of Blimp-1 Expression in Dendritic Cells in Autoreactive T Cell Receptor Repertoire A special thank you to our meeting sponsors