CbnœrResearch OFFICIAL JOURNAL OF THE AMERICAN ASSOCIATION FOR CANCER RESEARCH
Editor-in-Chief Carlo M. Croce
Managing Editor Associate Editors Margaret Foli Stuart A. Aaronson T. Michael Dexter Russell Hilf Michael J. Mastrangelo Joseph V. Simone Assistant Managing Editor Samuel Abraham Ralph E. Durand Tasuku Honjo Kenneth B. McCredie Beatrice Singer Mary Anne Mennite Jerry M. Adams Alan Eastman James N. Ihle Myron R. Melamed Francis M. Sirotnak Production Manager David S. Alberts Gertrude B. Elion John T. Isaacs John Mendelsohn Michael A. Sirover Heide M. Pusztay William M. Band Lois B. Epstein Mark A. Israel Thomas C. Merigan Arthur A. Spector Charles M. Balch M. Essex Rakesh K Jain Christopher J. Michejda Martha R. Stampfer Staff Editor Allan Balmain Emmanuel Farber Martha Michael Peter A. Jones John D. Minna Eric J. Stanbridge Mariano Barbacid Nelson Fausto V. Craig Jordan Malcolm S. Mitchell Gary S. Stein Editorial Assistants J. Carl Barrett Isaiah J. Fidler Robert F. Kallman Richard R. Monson Mary Elizabeth Ban- Bernard S. Strauss Renato Baserga Robert A. Floyd Ann R. Kennedy Harold L. Moses Takashi Sugimura Angela Barry William T. Beck Judah Folkman Robert S. Kerbel Sharon B. Murphy James A. Swenberg Gabrielle Vail Linda Pote Musumeci Thomas L. Benjamin Kenneth A. Foon Young S. Kim Paul Nettesheim Paul Talalay John M. Bennett Joseph F. Fraumeni, Jr. Tadamitsu Kishimoto Garth L. Nicolson James E. Talmadge Supervisor, Manuscript June L. Bicdler Errol C. Friedberg Alfred G. Knudson, Jr. Kenneth Nilsson David Tarin Masaaki 'I cruda Processing Peter M. Blumberg Philip Frost Kurt W. Kohn Jeffrey A. Norton Margaret A. Pickels Gianni Bonadonna Minoru Fukuda Laurence N. Kolonel Peter C. Nowell Snorri S. Thorgeirsson Peter J. O'Dwyer Editorial Secretaries G. Tim Bowden Philip Furmanski Donald W. Kufe Douglass C. Tormey Theresa A. Griffith Luther W. Brady Eugene W. Gerner John S. Lazo Gilbert S. Omenn Jeffrey M. Trent Mary Ellen Pirring Norman Breslow Leo E. Gerweck Bugni G. Leventhal C. Kent Osborne Giorgio Trinchieri Eleanor Avery Edward Bresnick Eli Glatstein Jay A. Levy Robert F. Ozols Peter Vaupel June A. Holloway Samuel Broder David W. Golde Frederick P. Li Michael A. Palladino, Jr. Ellen S. Vitella Sam C. Brooks Charles T. Gombar Michael W. Lieberman Peter L. Pedersen Daniel D. Von Hoff American Association for Ronald N. Buick Joel S. Greenberger Victor Ling Anthony E. Pegg Peter A. Ward Cancer Research. Inc. C. Patrick Burns J. W. Grisham Lance A. Liotta Angel Pellicer Michael D. Waterfield Executive Director Bruno Calabretta Gordon Hager Martin Lipkin Bice Perussia Lee W. Wallenberg Margaret Foti Bruce A. Chabner Sen-itiroh Hakomori Marc E. Lippman Sidney Pestka I. Bernard Weinstein Yung-chi Cheng Uli Hammerling Gerald Litwack W. J. Pledger Bengt Westermark Senior Administrator David Colcher Philip C. Hanawalt Kenneth O. Lloyd Donald J. Reed Raymond L. White Adam D. filistein Allan H. Conney Nabil Hanna Lawrence A. Loeb Ralph A. Reisfeld Sheldon Wolff Senior Accountant Neal G. Copeland Curtis C. Harris Dan L. Longo Richard A. Rifkind Sandra R. Wolman Anthony P. Blengino Joseph G. Cory Jules E. Harris Diana M. Lopez Joseph L. Roti Roti Charles W. Young Jeffrey Cossman John C. Harshbarger Reuben Lotan Berish Y. Rubin Sluart H. Yuspa Financial Assistant Frank Costantini Stephen S. Hecht James W. Lown George L. Moore Avery A. Sandberg Harald zur Hausen Benoit de Crombrugghe Ingegerd Hellstrom David B. Ludlum J. Schlessinger Meetings and Development Riccardo Dalla-Favera Brian E. Henderson Tak W. Mak Jeffrey Schlom Coordinator Eugene R. DeSombre Gloria H. Heppner Laurence J. Marton Manfred Schwab Jeffrey M. Ruben Executive Assistant for Programs Ruth E. Fortson Cover Editorial Board Administrative Assistant Sidney Weinhouse, Joseph H. Burchenal Hugh J. Creech Edwin A. Mirand Elizabeth A. Moore Cover Editor Nancy H. Colburn George H. Hitchings John H. Weisburger Secretary for Member Services Robin E. Felder Cancer Research is sponsored by the American Association for Cancer Research, Inc. and receives major support from the American Cancer Society, Inc. Publication costs are also met by a grant from the Elsa U. Pardee Foundation.
Subscription Information Cancer Research is published twice a month, one volume per year, by the American Association for Cancer Research, Inc. Subscriptions include the Proceedings of ine American Association for Cancer Research, issued in April of each year. Except for members of the American Association for Cancer Research, all subscriptions are payable in advance to Waverly Press, Inc.. 428 E. Preston Street, Baltimore, MD 21202, to which all business communications, remittances (in United States currency or its equivalenl), and subscriplion orders should be sent. In Japan, send orders and inquiries to (sole agent): USACO Corporalion, Tsutsumi Bldg., 13-12, Shimbashi 1-chome, Minato-ku, Tokyo 105, Japan; Tel. (03) 502-6471. Nonmembers of the American Association for Cancer Research within the United States may subscribe to the journal Cancer Research at the rate of $350.00 (individual and institutional nonmembers) per annual volume, including postage. Institutional and individual nonmembers outside of the United States should add $60.00 to their respective rates to offset second-class postage costs. Air mail and other means of delivery are available at extra charge; contact Waverly Press for information. Changes of address notification should be sent 60 days in advance and include both old and new addresses. Member subscribers should send address changes to: Member Services, American Association for Cancer Research, Inc., Public Ledger Building, Suite 816, 6th & Chestnut Streets, Philadelphia, PA 19106. Nonmember subscribers should notify Waverly Press of changes of address. Copies of the journal which are undeliverable because of address changes will be destroyed.