CbnœrResearch VOLUME 48 •NUMBER17 •CNREA8•PP4719-5064

CONTENTSf

Asterisks # preceding page numbers refer to studies using human-derived material.

BASIC SCIENCES 4790 Effect of Dietary Eicosapentaenoic Acid on Azoxymethane- induced Colon Carcinogenesis in Rats. Toshiyuki Minoura, $4719 Antagonism of Voltage-gated Calcium Channels in Small Cell Toshiyuki Takata, Michitomo Sakaguchi, Hideho Takada, Carcinomas of Patients with and without Lambert-Eaton My Manabu Yamamura, Koshiro Hioki, and Masakatsu Yamamoto. asthenie Syndrome by Autoantibodies w-Conotoxin and Ade- 4795 Isolation and Characterization of a Complementary DNA Clone nosine. Henry J. De Aizpurua, Edward H. Lambert, Guy E. for a \1, 32,000 Protein Which Is Induced with Tumor Promoters Griesmann, Baldomero M. Olivera, and Vanda A. Lennon. in BALB/c 3T3 Cells. Hajime Kageyama, Takaki Hiwasa, Katsuo Tokunaga, and Shigeru Sakiyama. 4725 Delivery of Melanoma-associated Immunoglobulin Monoclonal Antibody and Fab Fragments to Normal Brain Utilizing Osmotic 4799 Selective Modulation of Antibody Response and Natural Killer Blood-Brain Barrier Disruption. Edward A. Neuwelt, Peggy A. Cell Activity by l'uri in- Nucleoside Analogues. Teresa Priebe, Barnett, I. Hellström, K. E. Hellström, Paul Beaumier, Osama Kandil, Melila Nakic, Bih Fang Pan. and J. Arly Nelson. Christopher I. McCormick, and Ronald M. Weigel. 4804 Formation of Interstrand Cross-Links in Chloroacetaldehyde- 4730 Augmentation of Tumor Targeting in a Line of Glioma-specific treated DNA Demonstrated by Ethidium Bromide Fluorescence. Mouse Cytotoxic T-Lymphocytes by Retroviral Expression of S. J. Spengler and B. Singer. Mouse •Y-InterferonComplementary DNA. Kiyoshi Nishihara. 4807 Curative Effect of DL-2-Difluoromethylornithine in Mice Bearing Shinichi Miyatake, Tsuneaki Sakata, Junkoh Yamashita, Mutant I 1210 Leukemia Cells Deficient in Polyamine Uptake. Haruhiko Kikuchi, Yoshimi Kawade, Youli Zu, Yuziro Namba, Lo Persson, Ingvar Holm, Anders Ask, and Olle Heby. Masao Hanaoka, and Yoshihiko Watanabe. $4812 Abnormal Blood Monocytes in Chronic Lymphocytic Leukemia. 4736 Response of Radiation-induced Fibrosarcoma-1 in Mice to Cyclo- Dimitri Flieger and H. W. LömsZiegler-Heitbrock. phosphamide Monitored by in Vivo 'T Nuclear Magnetic Reso nance Spectroscopy. Shi-Jiang Li, Janna P. Wehrle, S. Sunder 4817 Novel Dehydroepiandrosterone Analogues with Enhanced Biolog Rajan, R. Grant Steen, Jerry D. Glickson, and John Hilton. ical Activity and Reduced Side Effects in Mice and Rats. Arthur G. Schwartz, Marvin L. Lewbart, and Laura L. Pashko. 4743 Glycosylation-dependent Collagen-binding Activities of Two Membrane Glycoproteins in MDAY-D2 Tumor Cells. Suzanne 4823 Gene Expression Caused by Alkylating Agents and cis- LafertéandJames W. Dennis. Diamminedichloroplatinum(II) in Escherichia cotí.Robert J. Fram, Jay Crockett, and Michael R. Volkert. 4749 Flavone Acetic Acid (NSC 347512(-induced Modulation of Mu $4827 Evaluation of a Soluble Tetrazolium/Formazan Assay for Cell rine Tumor Physiology Monitored by in Vivo Nuclear Magnetic Resonance Spectroscopy. Jeffrey L. Evelhoch, Marie-Christine Growth and Drug Sensitivity in Culture Using Human and Other Bissery, Guy G. Chabot, Nicholas E. Simpson, Cheryl L. McCoy, Tumor Cell Lines. Dominic A. Scudiere, Robert H. Shoemaker, Lance K. Heilbrun, and Thomas H. Corbett. Kenneth D. Paull, Anne Monks, Siobhan Tierney. Thomas H. Nofziger, Michael J. Currens, Donna Seniff, and Michael R. 4756 Isolation and Characterization of the Major Fluoranthene- Boyd. Hemoglobin Adducts Formed in Vivo in the Rat. Deborah A. 4834 Importance of Lyt-2* T-Cells in the Resistance of Melphalan- Hutchins, Paul L. Skipper, Stephen Naylor, and Steven R. cured MOPC-315 Tumor Bearers to a Challenge with Tannenbaum. MOPC-315 Tumor Cells. Edward Barker and Margalit B. Mokyr. 4762 Role of Oxygen Radicals in Induction of DNA Damage by Metab 4843 Enzyme-linked Immunosorbent Assay for the Quantification of olites of Benzene. J. G. Lewis, W. Stewart, and D. O. Adams. Actinomycin D Using 0-D-Galactosidase as a Label. Kunio 4766 Adriamycin-induced Free Radical Formation in the Perfused Rat Fujiwara, Tetsuya Saita, Noriko Takenawa, Naoki Matsumoto, and Tsunehiro Kitagawa. Heart: Implications for Cardiotoxicity. Sankaran Rajagopalan, Pedro M. Politi, Birandra K. Sinha, and Charles E. Myers. $4848 Identification of a Tumor-associated Target Antigen, A IM-1, for a Human T-Cell Clone with Activated Killer Activity and Its Ex $4770 Profiles of Prostaglandin Biosynthesis in Sixteen Established istence in Sera of Cancer Patients. Takeji Kaieda, Michio Cell Lines Derived from Human Lung, Colon, Prostate, and Imawari, Zen-ya Yamasaki, Shin Ohnishi, Michiko Koike, Yasuo Ovarian Tumors. Walter C. Hubbard, Michael C. Alley, Idezuki, and Fumimaro Takaku. Theodore L. McLemore, and Michael R. Boyd. $4855 Differential Expression of c-myc Gene and c-fos Gene in Pre- 4776 Regulatory Mechanisms of Monofunctional and Bifunctional An- malignant and Malignant Tissues from Patients with Familial ticarcinogenic Enzyme Inducers in Murine Liver. Hans J. Polyposis Coli. Kenji Sugio, Shun-ichi Kurata, Masayuki Sasaki, Prochaska and Paul Talalay. Jun-ichi Soejima, and Takehiko Sasazuki. $4783 Effects of Bombesin Antagonists on the Growth of Small Cell $4862 Inhibition of Human T-Cell Tumor Growth by I 101-Rk in Lung Cancer Cells in Vitro. Judith E. I.avion. Denis B. Scanion, A-Chain in an Athyntic Mouse Model. John E. Leonard, Duane Claire Soveny, and George Morstyn. E. Johnson, Daniel L. Shawler, and Robert O. Dillman. t The CONTENTS arranged by Subject Category can be found immediately following these CONTENTS.

Downloaded from cancerres.aacrjournals.org on September 29, 2021. © 1988 American Association for Cancer Research. Interferon Effects upon the Adenocarcinoma 38 and HL-60 Cell * 4969 Distribution and Imntunochemical Characterization of a Keratin- Lines: Antiproliferative Responses and Synergistic Interactions like Antigen in Epithelial Tumors Using Mouse and Human with Halogenated Pyrimidine Antimetabolites. Laurence Elias Monoclonal Antibodies. May-Kin Ho, Carol Geist, James and Harry A. Crissman. Murray, Ken Kato, Ronald DeLellis, Hubert Wolfe, Walter Carney, Harvey Rabin, and Paul Durda. *4K74 Association of Increased Platelet-derived Growth Factor Secre tion and Retroviral Expression in Transformed Mouse and Hu *4976 Response of Primary Human Lung Carcinomas to Autocrine man Cells. Gail C. Fraizer, Daniel F. Bowen-Pope, Ronald A. Growth Factors Produced by a Lung Carcinoma Cell Line. Jill M. Seifert, and Arthur M. Vogel. Siegfried and Sara E. Owens.

4881 Inhibition of Ionizing Radiation Recovery Processes in Poly- 4982 Selective Loss of Mitochondria! DNA after Treatment of Cells amine-depleted Chinese Hamster Cells. Eugene W. Gerner, with Ditercalinium (NSC 335153), an Antitumor Bis-intercalating Margaret E. Tome, Steven E. Fry, and G. Timothy Bowden. Agent. Evelyne Segal-Bendirdjian, Dominique Coulaud, Bernard P. Roques, and Jean-Bernard Le Pecq. 4886 Epidermal Growth Factor-induced Mitogenesis in Kidney Epithe lial Cells (LLC-PK,). James M. Mullin and Mary T. McGinn. * 4993 Malignant Properties of Sublines Selected from a Human Blad der Cancer Cell Line That Contains an Activated c-l la-rav On 4892 Effect of Microtubule Disorganizing or Overstabilizing Drugs on cogene. A. Kovnat, R. N. Buick, B. Choo, E. De Harven, the Proliferation of Rat 3T3 Cells and Their \ ¡rallyInduced I. Kopelyan, J. M. Trent, and I. F. Tannock. Transformed Derivatives. NédiaKamechand Roland Seif.

*4897 Highly Pigmented Human Melanoma Variant Which Metasta- CLINICAL AND EPIDEMIC-LOGICAL sizes Widely in Nude Mice, Including to Skin and Brain. Makoto INVESTIGATIONS Ishikawa, Bernard Fernandez, and Robert S. Kerbel.

4904 Growth-stimulatory Effect of Androgen-induced Autocrine 5001 Activity of the Cytosolic Isozyme of Thymidine Kinase in Human Growth Kactor(s)Secreted from Shionogi Carcinoma 115 Cells on Primary Lung Tumors with Reference to Malignancy. Toshikazu Androgen-unresponsive Cancer Cells in a Paracrine Mechanism. Yusa, Yutaka Yamaguchi, Hidemi Ohwada, Yutaka Hayashi, Norio Nonomura, Nobuyoshi Nakamura, Naomi Uchida, Namiko Kuroiwa, Tetsuo Monta, Mineko Asanagi, Yoichi Shinzaburo Noguchi, Bunzo Sato, Takao Sonoda, and Keishi Moriyama, and Shinji Fujimura. Matsumoto. 5007 Adoptive Immunotherapyof Human Cancer Using Low-Dose Re- 4909 Biliary Epithelial and Hepatocytic Cell Lineage Relationships in combinant Interleukin 2 and Lymphokine-activated Killer Cells. Embryonic Rat Liver as Determined by the Differential Expres Deric D. Schoof, Barbara A. Gramolini, David L. Davidson, sion of Cytokeratins, a-Fetoprotein, Albumin, and Cell Surface- Anthony F. Massaro, Richard E. Wilson, and Timothy J. exposed Components. Lucie Germain, Marie-JoséBlouin,and Eberlein. Normand Marceau. 5011 Local Administration of Autologous Lymphokine-activated Killer 4919 Lack of Expression of Glutathione-5-transferase P, -y-Glutamyl Cells and Recombinant Interleukin 2 to Patients with Malignant Transpeptidase, and a-Fetoprotein Messenger RNAs in Liver Tu Brain Tumors. Seiichi Yoshida, Ryuichi Tanaka, Nobuyuki mors Induced by Peroxisome Proliferato™.M. Sambasiva Rao, Takai, and Kohji Ono. Mohan R. Nemali, Nobuteru Usuda, Dante G. Scarpelli, Takao Makino, Henry C. Pilot, and Janardan K. Reddy. 5017 Natural Killer Cell Cytotoxicity in the Peripheral Blood, Cervical Lymph Nodes, and Tumor of Head and Neck Cancer Patients. *4926 Characterization of the ATPase Activity of the M, 170,000 to Robert A. Mickel, David J. Kessler, Jeremy M. G. Taylor, and 180,000 Membrane Glycoprotein (P-Glycoprotein) Associated Alan Lichtenstein. with Multidrug Resistance in KS62/ADM Cells. Hirofumi Hamada and Takashi Tsuruo. 5023 Immunoreactive a Transforming Growth Factor Activity in Effu sions from Cancer Patients as a Marker of Tumor Burden and 4933 Expression of Fibronectin on Clonally Related Transformed and Patient Prognosis. Carlos L. Arteaga, Axel R. Hanauske, Gary M. Control Sublines from an Epithelial Cell Strain and a Tumor Line Clark, C. Kent Osborne, Parul Hazarika, Robert L. Pardue, of Mouse Alveolus. John G. Steele, Tarja A. Savolainen, and FermínTio, and Daniel D. Von Hoff. Garry J. Smith.

4941 Clonal Diversity of the Kirsten-ros Oncogene during Tumor Pro 5029 Phase I Clinical and Pharmacokinetic Study of Trimetrexate Using a Daily x5 Schedule. James A. Stewart, John J. gression in Athymic Nude Mice: Mechanisms of Amplification and Rearrangement. Robert Radinsky, Paul M. Kraemer, Max R. McCormack, William Tong, Jane B. Low, John D. Roberts, Proffitt, and Lloyd A. Gulp. Alton Blow, Lloyd R. Whitfield, Larry D. Haugh, William R. Grove, Antonio J. Grillo Lopez, and Robert J. DeLap. 4954 Expression and Modulation of a Retrovirus-associated Antigen by Murine Melanoma Cells. Stanley P. L. Leong, Jacqueline Muller, 5036 Incidence of Cutaneous Melanoma in the United States by Histol Robert A. Vetter, Elieser Gorelik, Tsuyoshi Takami, and Vincent ogy with Special Reference to the Face. Guy R. Newell, Joanne J. Hearing. G. Sider, Louise Bergfelt, and Margaret L. Kripke. * 4959 Establishment of a Peripheral T-Cell Lymphoma Cell Line Show 5042 Seroepidemiology of Human T-Cell Lymphotropic Virus Type I ing Amplification of the c-myc Oncogene. Hitoshi Ohno, Shirou Infection in Taiwan. Chiu-Hwa Wang, Chien-Jen Chen, Chung- Fukuhara, Yuu Anta, Shoichi Doi, Rei Takahashi. Hiroshi Fujii, Yi Hu, San-Lin You, Chien-Ts Chu, Min-Ji Chou, Max Essex, Tasuku Honjo, Taketoshi Sugiyama, and Haruto Uchino. William A. Blattner, Chen-Hui Liu, and Czau-Siung Yang.

4964 Enhancement of Lung Tumor Colony Formation by Treatment of 5045 Persistently Elevated Sister Chromatid Exchanges in Ethylene Mice with Monoclonal Antibodies to Pulmonary Capillary Endo- Oxide-exposed Primates: The Role of a Subpopulation of High thelial Cells. Stephen J. Kennel, Trish K. Lankford, Robert L. Frequency Cells. Karl T. Kelsey, John K. Wiencke, Ellen A. Ullrich, and Roudabeh J. Jamasbi. Eisen, Dennis W. Lynch, Trent R. Lewis, and John B. Little. Continued

Downloaded from cancerres.aacrjournals.org on September 29, 2021. © 1988 American Association for Cancer Research. *** International Union against Cancer Fellowships and Personnel Exchanges Meeting Report Recent Deaths Calendar of Events 5051 Development of New Medium-Term Bioassays for Carcinogens. J. M. Ward and N. Ito. 5056 Errata J. Robert-Lézénèsetal., 48: 3972-3976, 1988. 5055 Announcements C. Tondini e! al., 48:4\07-4\ 12, 1988. Eightieth Annual Meeting of the AACR 5057 Employment Register of the American Association for Cancer Re AACR Special Conferences in Cancer Research search Future Annual Meetings of the AACR Collected Perspectives in Cancer Research 5064 Author Index

Applications for active and corresponding membership and for associate membership in the American Association for Cancer Research available in the back of this issue.

This One

Z04L-174-F6RL Downloaded from cancerres.aacrjournals.org on September 29, 2021. © 1988 American Association for Cancer Research. Cancer Research

VOLUME 48 •NUMBER 17

CONTENTS Arranged by Subject Category

BASIC SCIENCES Immunology Biochemistry and Biophysics $4719 Antagonism of Voltage-gated Calcium Channels in Small Cell Carcinomas of Patients with and without Lambert-Eaton My 4743 <, Iycosylat ion-dependent Collagen-binding Activities of Two asthenie Syndrome by Autoantibodies w-Conotoxin and Ade- Membrane Glycoproteins in MDAY-D2 Tumor Cells. Suzanne nosine. Henry J. De Aizpurua, Edward H. Lambert, Guy E. Lafette and James W. Dennis. Griesmann, Baldomcro M. Olivera, and Vanda A. Lennon. 4756 Isolation and Characterization of the Major Fluoranthene- 4725 Delivery of Melanoma-associated Immunoglobulin Monoclonal Hemoglobin Adducts Formed in Vivo in the Rat. Deborah A. Antibody and Fab Fragments to Normal Brain Utilizing Osmotic Hutchins, Paul L. Skipper, Stephen Naylor, and Steven R. Blood-Brain Barrier Disruption. Edward A. Neuwelt, Peggy A. Tannenbaum. Barnett, I. Hellström, K. E. Hellström, Paul Beaumier, * 47711 Profiles of Prostaglandin Biosynthesis in Sixteen Established Christopher I. McCormick, and Ronald M. Weigel. Cell Lines Derived from Human Lung, Colon, Prostate, and Ovarian Tumors. Walter C. Hubbard, Michael C. Alley, 4730 Augmentation of Tumor Targeting ¡na Line of Glioma-specific Theodore L. McLemore, and Michael R. Boyd. Mouse Cytotoxic T-Lymphocytes by Retroviral Expression of Mouse 7-Interferon Complementary DNA. Kiyoshi Nishihara, 4804 Formation of Interstrand Cross-Links in Chloroacetaldehyde- Shinichi Miyatake, Tsuneaki Sakata, Junkoh Yamashita, treated DNA Demonstrated by Ethidium Bromide Fluorescence. Haruhiko Kikuchi, Yoshimi Kawade, Youli Zu, Yuziro Namba, S. J. Spengler and B. Singer. Masao Hanaoka, and Yoshihiko Watannabe. $4926 Characterization of the ATPase Activity of the M, 170,000 to 180,000 Membrane Glycoprotein (P-Glycoprotein) Associated 4799 Selective Modulation of Antibody Response and Natural Killer with Multidrug Resistance in K562/ADM Cells. Hirofumi Cell Activity by Purine Nucleoside Analogues. Teresa Priebe, Hamada and Takashi Tsuruo. Osama Kandil, Melila Nakic, Bih Fang Pan, and J. Arly Nelson. 4933 Expression of Fibronectin on Clonally Related Transformed and $4812 Abnormal Blood Monocytes in Chronic Lymphocytic Leukemia. Control Sublines from an Epithelial Cell Strain and a Tumor Line Dimitri Flieger and H. W. LömsZiegler-Heitbrock. of Mouse Alveolus. John G. Steele, Tarja A. Savolainen, and 4834 Importance of I .yt-2 ' T-Cells in the Resistance of Melphalan- Garry J. Smith. cured MOPC-315 Tumor Bearers to a Challenge with Carcinogenesis MOPC-315 Tumor Cells. Edward Barker and Margalit B. Mokyr.

4762 Role of Oxygen Radicals in Induction of DNA Damage by Metab $4848 Identification of a Tumor-associated Target Antigen, ATM-1, for olites of Benzene. J. G. Lewis, W. Stewart, and D. O. Adams. a Human I -Cell Clone with Activated Killer Activity and Its Ex istence in Sera of Cancer Patients. Takeji Kaieda, Michio 4776 Regulatory Mechanisms of Monofunctional and Bifunctional An- Imawari, Zen-ya Yamasaki, Shin Ohnishi, Michiko Koike, Yasuo ticarcinogenic Enzyme Inducers in Murine Liver. Hans J. Idezuki, and Fumimaro Takaku. Prochaska and Paul Talalay. 4790 Effect of Dietary Eicosapentaenoic Acid on Azoxymethane- $ 4969 Distribution and Immunochemical Characterization of a Keratin- induced Colon Carcinogenesis in Rats. Toshiyuki Minoura, like Antigen in Epithelial Tumors Using Mouse and Human Toshiyuki Takata, Michitomo Sakaguchi, Hideho Takada, Monoclonal Antibodies. May-Kin Ho, Carol Geist, James Manabu Yamamura, Koshiro Hioki, and Masakatsu Yamamoto. Murray, Ken Kato, Ronald DeLellis, Hubert Wolfe, Walter Carney, Harvey Rabin, and Paul Durda. 4817 Novel Dehydroepiandrosterone Analogues with Enhanced Biolog ical Activity and Reduced Side Effects in Mice and Rats. Arthur G. Schwartz, Marvin L. Lewbart, and Laura L. Pashko. Molecular Biology and Genetics

4886 Epidermal Growth Factor-induced Mitogenesis in Kidney Epithe 4795 Isolation and Characterization of a Complementary DNA Clone lial Cells (LLC-PK,). James M. Mullin and Mary T. McGinn. for a M, 32,000 Protein Which Is Induced with Tumor Promoters 4892 Effect of Microtubule Disorganizing or Overstabilizing Drugs on in BALB/c 3T3 Cells. Hajime Kageyama, Takaki Hiwasa, the Proliferation of Rat 3T3 Cells and Their Virally Induced Katsuo Tokunaga, and Shigeru Sakiyama. Transformed Derivatives. NédiaKamech and Roland Seif. $4855 Differential Expression of c-myc Gene and c-fos Gene in Pre- 4909 Biliary Epithelial and Hepatocytic Cell Lineage Relationships in malignant and Malignant Tissues from Patients with Familial Embryonic Rat Liver as Determined by the Differential Expres Polyposis Coli. Kenji Sugio, Shun-ichi Kurata, Masayuki Sasaki, sion of Cytokeratins, a-Fetoprotein, Albumin, and Cell Surface- Jun-ichi Soejima, and Takehiko Sasazuki. exposed Components. Lucie Germain, Marie-José Blouin, and Normand Marceau. 4919 Lack of Expression of Glutathione-S-transferase P, 7-Glutamyl Transpeptidase, and a-Fetoprotein Messenger RN As in Liver Tu Endocrinology mors Induced by Peroxisome Proliferators. M. Sambasiva Rao, Mohan R. Nemali, Nobuteru Usuda, Dante G. Scarpelli, Takao 4904 Growth-stimulatory Effect of Androgen-induced Autocrine Makino, Henry C. Pilot, and Janardan K. Reddy. Growth Factoids) Secreted from Shionogi Carcinoma 115 Cells on Androgen-unresponsive Cancer Cells in a Paracrine Mechanism. 4941 Clonal Diversity of the Kirsten-nu Oncogene during Tumor Pro Nono Nonomura, Nobuyoshi Nakamura, Naomi Uchida, gression in Athymic Nude Mice: Mechanisms of Amplification Shinzaburo Noguchi, Bunzo Sato, Takao Sonoda, and Keishi and Rearrangement. Robert Radinsky, Paul M. Kraemer, Max R. Matsumoto. Proffitl, and Lloyd A. Gulp. * Indicates studies using human-derived material.

Downloaded from cancerres.aacrjournals.org on September 29, 2021. © 1988 American Association for Cancer Research. * 4959 Establishment of a Peripheral T-Cell Lymphoma Cell Line Show 4954 Expression and Modulation of a Retrovirus-associated Antigen by ing Amplification of the c-myc Oncogene. Hitoshi Ohno, Shirou Murine Melanoma Cells. Stanley P. L. Leong, Jacqueline Muller, Fukuhara, Yuu Arila, Shoichi Doi, Rei Takahashi, Hiroshi Fujii, Robert A. Yetter, Elieser Gorelik, Tsuyoshi Takami, and Vincent Tasuku Honjo, Taketoshi Sugiyama, and Haruto Uchino. J. Hearing.

$4993 Malignant Properties of Sublines Selected from a Human Blad 4964 Enhancement of Lung Tumor Colony Formation by Treatment of der Cancer Cell Line That Contains an Activated c-Ha-nu On Mice with Monoclonal Antibodies to Pulmonary Capillary Endo- cogene. A. Kovnat, R. N. Buick, B. Choo, E. De Harven, thelial Cells. Stephen J. Kennel, Trish K. Lankford, Robert L. I. Kopelyan, J. M. Trent, and I. F. Tannock. Ullrich, and Roudabeh J. Jamasbi. Preclinical Pharmacology and Experimental Therapeutics %49?6 Response of Primary Human Lung Carcinomas to Autocrine 4736 Response of Radiation-induced Fibrosarcoma-1 in Mice to Cyclo- Growth Factors Produced by a Lung Carcinoma Cell Line. Jill M. phosphamide Monitored by in Vivo "I* Nuclear Magnetic Reso Siegfried and Sara E. Owens. nance Spectroscopy. Shi-Jiang Li, Janna P. Wehrle, S. Sunder Rajan, R. Grant Steen, Jerry D. Glickson, and John Hilton. 4982 Selective Loss of Mitochondria! DNA after Treatment of Cells with Ditercalinium (NSC 335153), an Antitumor Bis-intercalating 4749 Flavone Acetic Acid (NSC 347512»-induced Modulation of Mu Agent. Evelyne Segal-Bendirdjian. Dominique Coulaud, Bernard rine Tumor Physiology Monitored by in Vivo Nuclear Magnetic P. Roques, and Jean-Bernard Le Pecq. Resonance Spectroscopy. Jeffrey L. Evelhoch, Marie-Christine Bissery, Guy G. Chabot, Nicholas E. Simpson, Cheryl L. McCoy, Lance K. Heilbrun, and Thomas H. Corbett. CLINICAL AND EPIDEMIOLOGICAL INVESTIGATIONS 4766 Adriamycin-induced Free Radical Formation in the Perfused Rat Heart: Implications for Cardiotoxicity. Sankaran Rajagopalan, Clinical Pedro M. Politi, Birandra K. Sinha, and Charles E. Myers.

4807 Curative Effect of Di.-2-Difluoromethylornithine on Mice Bearing 5001 Activity of the Cytosolic Isozyme of Thymidine Kinase in Human Primary Lung Tumors with Reference to Malignancy. Toshikazu Mutant 1,12111 Leukemia Cells Deficient in Polyamine Uptake. Lo Persson, Ingvar Holm, Anders Ask, and Olle Heby. Yusa, Yutaka Yamaguchi, Hidemi Ohwada, Yutaka Hayashi, Namiko Kuroiwa, Tetsuo Monta, Mineko Asanagi, Yoichi 4823 Gene Expression Caused by Alkylating Agents and cis- Moriyama, and Shinji Fujimura. Diamminedichloroplatinum(II) in Escherichia coli. Robert J. Fram, Jay Crockett, and Michael R. Volkert. 5007 Adoptive Immunotherapy of Human Cancer Using Low-Dose Re- combinant Interleukin 2 and Lymphokine-activated Killer Cells. $4827 Evaluation of a Soluble Tetrazolium/Formazan Assay for Cell Deric D. Schoof, Barbara A. Gramolini, David L. Davidson, Growth and Drug Sensitivity in Culture Using Human and Other Anthony F. Massaro, Richard E. Wilson, and Timothy J. Tumor Cell Lines. Dominic A. Scudiere, Robert H. Shoemaker, Eberlein. Kenneth D. I'aull. Anne Monks, Siobhan Tierney, Thomas H. Nofziger, Michael J. Currens, Donna Seniff, and Michael R. 5011 Local Administration of Autologous Lymphokine-activated Killer Boyd. Cells and Recombinant Interleukin 2 to Patients with Malignant 4843 Enzyme-linked Immunosorbent Assay for the Quantification of Brain Tumors. Seiichi Yoshida, Ryuichi Tanaka, Nobuyuki Actim mycin D Using /?-r>-Galactosidase as a Label. Kunio Takai, and Kohji Ono. Fujiwara, Tetsuya Saita, Noriko Takenawa, Naoki Matsumoto, and Tsunehiro Kitagawa. 5017 Natural Killer Cell Cytotoxicity in the Peripheral Blood, Cervical Lymph Nodes, and Tumor of Head and Neck Cancer Patients. $4862 Inhibition of Human I-(ell Tumor Growth by Tl 01-Ricin Robert A. Mickel, David J. Kessler, Jeremy M. G. Taylor, and A-Chain in an Athymic Mouse Model. John E. Leonard, Duane Alan Lichtenstein. E. Johnson, Daniel L. Shawler, and Robert O. Dillman.

*486X Interferon Effects upon the Adenocarcinoma 38 and III -6(1 Cell 5023 Immunoreactive a Transforming Growth Factor Activity in Effu Lines: Antiproliferative Responses and Synergistic Interactions sions from Cancer Patients as a Marker of Tumor Burden and with Halogenated Pyrimidine Antimetabolites. Laurence Elias Patient Prognosis. Carlos L. Arteaga, Axel R. Hanauske, Gary M. and Harry A. Crissman. Clark, C. Kent Osborne, Parul Hazarika, Robert L. Pardue, FermínTio. and Daniel D. Von Hoff. 4881 Inhibition of Ionizing Radiation Recovery Processes in Poly- amini-depleted Chinese Hamster Cells. Eugene W. Gerner, 5029 Phase I Clinical and Pharmacokinetic Study of Trimetrexate Margaret E. Tome, Steven E. Fry, and G. Timothy Bowden. Using a Daily x5 Schedule. James A. Stewart, John J. McCormack, William Tong, Jane B. Low, John D. Roberts, Tumor Biology Alton Blow, Lloyd R. Whitfield, Larry D. Haugh, William R. Grove, Antonio J. Grillo Lopez, and Robert J. DeLap. *47K3 Effects of Bombesin Antagonists on the Growth of Small Cell Lung Cancer Cells in Vitro. Judith E. Layton, Denis B. Scanion, Claire Soveny, and George Morstyn. Epidemiological

$4874 Association of Increased Platelet-derived Growth Factor Secre- 5036 Incidence of Cutaneous Melanoma in the United States by Histol ogy with Special Reference to the Face. Guy R. Newell, Joanne ttion and retroviral Expression in Transformed Mouse and Hu man Cells. Gail C. Fraizer, Daniel F. Bowen-Pope, Ronald A. G. Sider, Louise Bergfelt, and Margaret L. Kripke. Seifert, and Arthur M. Vogel. 5042 Seroepidemiology of Human T-Cell Lymphotropic Virus Type I *4K97 Highly Pigmented Human Melanoma Variant Which Metasta- Infection in Taiwan. Chiu-Hwa Wang, Chien-Jen Chen, Chung- sizes Widely in Nude Mice, Including to Skin and Brain. Makoto Yi Hu, San-Lin You, Chien-Ts Chu, Min-Ji Chou, Max Essex, Ishikawa, Bernard Fernandez, and Robert S. Kerbel. William A. Blattner, Chen-Hui Liu, and Czau-Siung Yang. Continued

Downloaded from cancerres.aacrjournals.org on September 29, 2021. © 1988 American Association for Cancer Research. 5045 Persistently Elevated Sister Chromatid Exchanges in Ethylene International Union against Cancer Fellowships and Personnel Oxide-exposed Primates: The Role of a Subpopulation of High Exchanges Frequency Cells. Karl T. Kelsey, John K. Wiencke, Ellen A. Recent Deaths Eisen, Dennis W. Lynch, Trent R. Lewis, and John B. Little. Calendar of Events

* * * 5056 Errata Meeting Report J. Robert-Lézénèsetal., 48: 3972-3976, 1988. 5051 Development of New Medium-Term Bioassays for Carcinogens. C. Tondini et al., 48: 4107-4112, 1988. J. M. Ward and N. Ito. 5055 Announcements 5057 Employment Register of the American Association for Cancer Re Eightieth Annual Meeting of the AACR search AACR Special Conferences in Cancer Research Future Annual Meetings of the AACR Collected Perspectives in Cancer Research 5064 Author Index

Applications for active and corresponding membership and for associate membership in the American Association for Cancer Research available in the back of this issue.

Downloaded from cancerres.aacrjournals.org on September 29, 2021. © 1988 American Association for Cancer Research. 48 (17)

Cancer Res 1988;48:4719-5063.

Updated version Access the most recent version of this article at: http://cancerres.aacrjournals.org/content/48/17.citation

E-mail alerts Sign up to receive free email-alerts related to this article or journal.

Reprints and To order reprints of this article or to subscribe to the journal, contact the AACR Publications Subscriptions Department at [email protected].

Permissions To request permission to re-use all or part of this article, use this link http://cancerres.aacrjournals.org/content/48/17.citation. Click on "Request Permissions" which will take you to the Copyright Clearance Center's (CCC) Rightslink site.

Downloaded from cancerres.aacrjournals.org on September 29, 2021. © 1988 American Association for Cancer Research.