October l 1, 1994 Vol. XLVI No. 21 "Still U.S. Department of Health The Second and Human Services Best Thing About Payday" National Institutes of Health Dunbar To Give First Pittman Lecture, Oct. 26 By Sara Byars scientist recognized internarionally for A her pioneering work in contraceptive vaccines has been selected to deliver the first Margaret Pittman Lecture, a new NIH series chat honors outstanding women scientists. Dr. Bonnie S. Dunbar, professor of cell . :/ biology and obstetrics and gynecology at Baylor College of Medicine, will speak on "New ':'' .:' f ,; ...... Fromiers in Reproductive Biology and I !- J ~ , • I , , ' f ., ' / , , Contraceptive Vaccines" at 3 p.m. on 0cc. 26 ' • /} : 4 t ., : in Masur Auditorium, Bldg. I 0 . . . ' ' . ! • ' I I I • Guiding che development of che Pittman • ' ' ,• ,: k'I I ' I lectureship series is the NIH women scientists J: • ! • •'I I It♦ l'- : ,4 • • •· ... / ;~ ~ advisory committee, a group char advises At the NIH Research Festival 1994 poster session, Dr. Lynn Hudson (r), chief. molecular genetics section scientific directors on matters pertaining co rhe ofNJNDS' Laboratory ofViral and Molecular Pathogenesis, stops by to view the work ofDr. Rosemary role of women scientists at NIH. Wong, one ofthe authors who works in NIDDK's Molemlar, Cellular and Endocrinology Branch. See This lectureship honors Or. Margaret additional coverage ofthe event on Pages 6-7. Pittman, rhe first woman co hold the position (See PITTMAN LECTURE, Page 2) NIGMS Reorganizes, Moves to Natcher Bldg. is month, che N acional Institute of General Medical Sciences is undergoing a reorganiza­ Vitetta Is NIAID's 1994 tion and a move to che new William H. Natcher Bldg. on the main NIH campus. The Kinyoun Lecturer, Oct. 20 reorganization is designed ro enhance che inscicuce's effectiveness and efficiency in T r. Ellen S. Virecra, who is known for her supporting basic biomedical research and research training, as well as co align NIGMS' organiza­ pioneering contributions to under­ tional scruccuce and position tides wich chose of ocher NIH insticuces. D standing che immunobiology of B cells, will The most significant change is che rearrangement of four program branches-Cellular and present NWD's Kinyoun Lecture on Thurs­ Molecular Basis of Disease; Genetics; Biophysics and Physiological Sciences; and Pharmacology and day, 0cc. 20 ac 2 p.m. in Lipsett Amphitheater, Biorelated Chemistry-into three divisions: Cell Biology and Biophysics; Genetics and Develop­ Bldg. 10. The rirle of the ralk is "Antibodies as mental Biology; and Pharmacology, Physiology, and Biological Chemistry. According co Dr. Carriers of Toxins and as Agonises in Cancer Marvin Cassman, acting NIGMS director, "The reorganization reAects che increasingly interdisci­ Therapy." plinary nature of the research funded by NIGMS. By refining che discribucion and balance of Since 1988, Virerra has been director of che (See REORGANIZATION, Page 4) Cancer lmmunobiology Center at the Univer­ 1994 Lasker Award Signal Transduction Is sity of Texas Souchwestern Medical Center in Winners Are Grantees Focus of Stetten Lecture Dallas. In her studies of the mechanisms underlying he three winners of 1994 Alben ll cells-from the simplest one-celled rhe activation and differentiation of immune Lasker Medical Research Awards share, T A organisms co rhe highly specialized cells cells known as B lymphocytes, she was che first in addition co disringuished medical careers, a of planes and animals-are continually co biochemically characterize both IgM and rich funding history ac NIH. Together, chey bombarded by information from che outside IgD antigen-specific receptors on B lympho- account for some $64 million in funds for world. A central quesrion in the srudy of cell (See KINYOUN LECTURE, Page 8) research and training acrivicies spread across biology is how messages from che oucside are more than JOO NIH grants. relayed through the cell ro the nucleus, where, NIDCD Invites Hudspeth The winners are: Dr. Stanley B. Prusiner, through rhe actions of selected genes, appropri­ To Lecture on Hearing who received the Basic Research Award for ate responses are made. This process, called discovering prions, a completely new class of signal transduction, is che focus of the research r. Albert J. Hudspeth will give the disease-causing agents rhac cause several rare conducted by Dr. Sruarc L. Schreiber, a D NlDCD Anniversary Lectute entitled, neurodegenerative diseases; Dr. John A. professor of chemistry and molecular and "How Hearing Happens: Mechanoeleccrical Clements, who won the Clinical Medical cellular biology at Harvard Universiry. Transduction, Frequency Tuning, and Synapric (See LASKER, Page 8) (See STETTEN, Page 9} Transmission." A distinguished scientist whose research focuses on the movement of sensory NIAID's Hartley Lauded receptors in che inner ear called hair cells, he By Greg Folkers Healy Portrait Unveiling Set will speak on Thursday, 0cc. 27 ac 11 a.m. in he extraordinary scientific accomplish­ There will be a portrait unveiling for Lister Hill Auditorium, Bldg. 38A. Sign ments and 41-year NIH career of T former NIH direcror Dr. Bernadine Healy language interpreting will be provided. virologist Or. Janet W. Hardey, chief of the on Wednesday, 0cc. 12 ac 10 a.rn. in Hudspeth is a professor in che department of viral oncology section in NlAID's Laboratory Wilson Hall, Bldg. I. Healy and Ruch cell biology and neuroscience, director of the of lmmunoparhology, were celebrated recencly Bryant ofAmarillo, Tex., the anise who Center for Basic Neuroscience Research, and in a scientific symposium ac rhe Clinical painted che portrait, will be present for the investigator, Howard Hughes Medical Cenrer. Paying tribute to Hartley in scientific occasion. All NIH'ers are welcome to Inscicuce, University of Texas Southwesrern presentations were a "Who's Who" of prorni- attend. Medical Center ac Dallas. He received both his (See HARTLEY, Page 5) (See HUDSPETH, Page 4) page 2

The Record Ocrober I I , 1994

PITTMAN LECTURE ovulated eggs and embryos before they are (Continued from Page 1) implanted. oflaboraro1y chief at NIH, explains Dr. Susan Dunbar has dcmonsrraced char a vaccine Swedo, women scientists advisory committee made from zona pellucida proteins can trigger chair and acting deputy scientific d irector of an immune response char destroys che ovarian NIMH. "She exemplifies rhe best in scientific follicles in several species of mammals. "Our investigation and her pioneering work in current srudies are to identify which protein vaccine develop­ and which form of protein produced by ment has left a recombinant DNA technology are as effective lasting mark on as rhe narive protein," she adds. health care Dunbar earned her bachelor's degree in worldwide. We zoology and master's degree in physiology at are honored ro rhe University of Colorado, Boulder, and a have Dr. Dunbar Ph.D. in zoology at the University of deliver the first Tennessee, Knoxville. She did postdoctoral lecrure. Her work work at rhe University of California at Davis in contraceptive in biochemistry and biophysics. Prior ro vaccine research joining the Baylor medical school faculty in could have the 1981, she was staff scien cisr for rhe Population same far-reaching Council at the Rockefeller Universiry. Robyn Strachan, former budget officer with impact on the T he lecrure series honors N!NR, has been appointed budget officer far q uality of health Dr. Bonnie Dunbar Pirrman, who was named, NIAMS. She wilt be mpomible for all pha;e; of and life." in 1958, chiefof che budget formulation in mpport ofNJAMS Dunbar is noted for her work in developing Laboratory of appropriation; and will ;erve as principal con traceptive vaccines. "In humans, rhe Bacterial Products in financial advi;or to the imritute director. research is geared coward developing a vaccine the Division of using antibodies to keep the sperm from Biological Standards, Heritage Program Planning Starts binding to and fertilizing the egg," D unbar which was at the time explains. "The vaccine under development is a part of NIH. She is The first planning meeting for the 23rd being designed so that it is effective bur will noted for her annual Asian/Pacific American Heritage not affect the ovary or alter normal hormone significant contribu­ Program at NIH is scheduled for Friday, Oct. levels." tions co microbiology, 21 ar noon in the Little Theater, Visitor Another form of the vaccine is being including devising serological typing methods Information Center, Bldg. 10. The program developed for animal sterilization. Ir is a for identifying Hemophi/u;, and for vaccine will be held in May 1995. All interested parties humane alternative to surgical spaying of dogs development, especially for her work in are invited to attend che planning meeting. For and cars, for example, and ro slaying of animah pertussis and tetanus toxin vaccines. more information, call Victor Fung, 6-3511. D such as elephants because of overpopulation in A native of Prairie Grove, Ark., Pittman restricted habitats, she adds. earned her master's and Ph.D. degrees in T his vaccine works by wiping out ovarian bacteriology at rhe University of Chicago. She follicular development. The desired result for came co NIH in 1936, and retired in 1971. The NIH Record chis vaccine in most animals, she says, is After her retirement, she continued co serve as Published biweekly ar Berhesda, Md., by 1he Edirorial permanent sterilization and blockage of estrus. consultant co medical and scienrific organiza­ Op<:rarions Branch, Division of Public Information, for The vaccine is developed from proteins from tions arou nd the world and was a guest worker the information of cmploy«s of chc National In.srituces. of Healrh, Depariment of Health a.nd Hurnan Services. The the zona pellucida. The zona pellucida, for the Division of Biologic Standards of the conrcnr i.s reprinrable without permission. Picmres may be I irerally rhe zone char allows rhe passage of Food and Drug Administration's Center for available on requesr. Use of funds for prinring ,his periodical light, is rhe coating char surrounds t he oocyccs, Drugs and Biologics. D has been approved by 1he direcror of the Office of Manage­ ment and Budget through September 30, 1995. NIH Record Office Correspondents: NCRR To Host International Meeting on Animal Science 13ldg. 31, Room 2B-03 CC, Sara Byars On Ocr. 24, NCRR's Veterinary Resources Program will hose the 15th annual meeting of the Phone 6-2125 DCRT, Mary Hodges U.S.-Japan laboracory animal science commircee. The committee establishes uniform international Fax 2-1485 DRG, Judich Grover standards for laboratory animal research. FIC, Irene Edwards This year's meeting fearures a scientific session on rhe use of transgenic animals in medical Editor NCI, Parricia A. Newman Richard McManus research. From 8 a.m. co 12:30 p.m. ar the Fogany Internacional Center's Scone House, scientists NCHGR, Leslie Fink NCRR, Frances Taylor from both countries will make presentations on the development of transgenic animal models for Assistant Editor polio, spondyl.itis, and various neurologic and muscular disorders. Anne Barber NE!, Linda Huss NHLBI, Louise Williams The laboratory animal science committee was established under the U.S.-Japan Joint Program for NlA, Vicky Cahan Cooperation in Research and Developmenr in Science, which promores exchange of scientific and Associate Editor Carla Garnetr NIAAA, Ann M. Bradley tech nological information. In its most recent cormibucion co chis effort, rhe comminee developed NIAID, James Hadley and published a revised second edition of rhc Manual for Microbiologic Monitoring oflaboratory NIAMS, Amy Iadarola Animals. NICHD, Carol Florance All NIH scientists are welcome to attend the scientific session. For more information, contact NIDA, Mona Brown Dr. Dave Madden, 6-4463. D NIDCD, Gail Blacr NIDDK, Ei leen Corrigan Chamber Music Concert Will Be Held Oct. 16 NIDR, Mary Daum The Rock Creek Chamber Players wi ll perform Rossini's duet for cello and double bass, Th~ NIH Rri-Qrd re$.cn:cs NIEHS, T homas Hawkins Hindemith's sonata for flure and piano, and Schumann's quarter for piano and strings in E flar the right m make NIGMS, Wanda Warddcll corrections, changes. or NIMH, Marilyn Weeks major, opus 47, o n Sunday, Oct. 16 at 3 p.m. in the 14th floor assembly hall, Bldg. 10. The deletions in submitted NINOS, Shannon Garne11 concerr, sponsored by the recreation therapy section, is free and open to rhe public. For more copy in conformity wilh the policies of the paper NINR, Marianne Duffy information call (202) 337-8710. D and HHS. NLM, Roger L. Gilkeson page 3

The Record Ocrober 11, I 994

Agreement Accelerates Work in Cellular Therapies

By Sue Kendall Cellular therapies are at the vanguard of complementary research pursuits made it a justifiably proud that DTM helped to develop medical research roday. Human blood cells prudent choice for collaboration. Baxter, a techniques such as growing cells in blood bags can now be modified ro treat cancer, infec­ leader in health-care products, systems, and rhac allowed gene therapy to be exported to tions, and many inherited diseases. Examples services, has expertise in manufacturing cenrers worldwide. include inserting genes into cells or enhancing biologics that meet federal standards. DTM DTM currently processes cells for a dozen a cell's immune response. The Clinical Center's department of CRADAs Explained transfusion medicine (DTM) has nailed down a leading role in chis booming research area by A Cooperative Research and Development public as a useful, marketable product." NIH signing a Cooperative Research and Develop­ Agreement (CRADA) is a mechanism by presently has 206 CRADAs, six of which are ment Agreement (CRADA) with Baxter which NIH investigators can collaborate Clin ical Center-based. Usually written for 1 H ealthcare Corp. Such an agreement enables with colleagues from industry and academia to 4 years, CRADAs can be extended. NIH ro collaborate with private indusrry on co pursue common research goals. Each Derractors argue rhat CRADAs put specific research projects, and spells our party contributes unique resources to the government in industry's back pocket. The licensing and parent issues char can. vex less effort such as expertise or hard-ro-get agreement, however, stares char, "CRADAs formal associations. research materials. Either parry can initiate a are nor viewed by NIH as a general funding Certain business, financial, and scientific CRADA. source or as a mechanism for sponsored information in any C RADA must remain Under the CRADA, rhe outside company research." DTM chief Dr. Harvey G. Klein confidential. However, the broad goals of rhe is given rhe option co license inventions concurs. "There is an intellectual concribu. DTM agreement are ro develop and improve developed within the project's research rion from both sides; it's not simply money." procedures for collecting, modifying, growing, scope. At present, NIH retains some concrol He stresses that having a CRADA wich one and preserving human cellular components, over pricing of che invenrions ro protect the company does not preclude association with according to DTM chief Dr. Harvey G. Klein. taxpayers' investment. This provision is another company or use of its products. The crucible for such curring-edge research will being reevaluated to see if it helps or hinders Another criticism ofCRADAs is char the be a 3,000-square-foor Cell Processing NIH objectives, according co Dr. Jane outside collaborator can potentially exercise Laboratory, to be built atop the existing DTM Biddle of NIAID's Technology Transfer coo mucl1 control over the research direction. wing. Construction is slated to begin in 6 co 9 Branch, who coordinated the DTM-Baxter "True, a CRADA's research plan spells out months and will take a year or so. Although CRADA. specific objectives, which some see as the lab is not yet built, studies are already The Federal Technology Transfer Act of restrictions on research freedom," says Biddle. under way in DTM labs, with Baxter staff 1986 encourages interaction and technology "However, if appropriate, the research plan onsice. transfer between federal government and can be amended to incorporate serendipitous Since the groundbreaking gene therapy industry through CRADAs. Says Biddle, [chance] findings rhar may or may not have protocol of 1990, in which DTM played a "Collaboration with industry allows us to commercial interest." Such specificity is crucial role, modified cells have come under further the development of scientific and precisely what keeps the collaborator from increasing scrutiny by rhe Food and Drug technological knowledge, and bring it ro the having undue influence, she says. Administration. "When you start removing cells, growing chem, modifying them, and purring chem back inco a human being, you has expertise in cellular therapy and access co prorocols from four insri tutes. Klein expects become, in essence, a biologics manufacturer," clinical facilities and patients. Says Klein, "We chis number to grow, which presents some explains Klein. A biologic is a treatment hope char combining these areas of expertise challenges. CRADA studies will look ac derived from a living organism, for example, a will benefit NIH and Baxter and ultimately rhe conrrolling the process of manipulating billions vaccine. Depending on how much the cells are general public," as cellular therapies make their of cells according to the specifications of many modified, they could even be considered way imo mainstream medicine. protocols. Automation, cracking, labeling, and medical devices, he says. "You have to make Klein foresees that FDA will look to the equipment are all areas for research and sure you're manufacturing this biologic in a research results for guidance as it formulates development. "I think [chis CRADA) is a very manner char is safe and appropriate for human regulations on cellular therapies. "This is an good thing for NlH. Without it, it's unlikely use." uncharted area," he says. But Klein's ream has that the various intramural programs could Klein believed chat Baxter's involvement in navigated u ncharted waters before. He is proceed as rapidly." 0 'Internet Today and Tomorrow' Conference Set, Oct. 24 Are you an Internet user? Do you provide sity of Illinois at Urbana-Champaign; Barbara ogy Trends." In addition, there will be a panel services on the Internet? Do you provide Fraser, a representative from che Carnegie composed of NIH representatives who will Internee access ro the NlH community? Then Mellon Computer Emergency Response Team; discuss !CD-specific Internet issues. you will nor want to miss the NIH-wide and Brendan Kehoe, author of Zen and the Art Don't miss chis opportunity ro learn more conference, "Internet Today and Tomorrow," ofInternet. about current issues and future trends predicted sponsored by the Office oflnformarion Plan to spend all day on Oct. 24 or drop in as for the world's largest computer network. For Resources Management (OIRM) in the Office you have rime. The morning session, located more information, contact Mary DeLisi, 2- of the Director. in Lister Hill Auditorium, Bldg. 38A from 8:30 4462 or [email protected]. 0 T he conference will provide an opportunity to 11 :45, includes two presentations: Ross for NIH employees ro explore Internet trends Srapleton•Gray speaking on "Imerner: Where Free Flu Immunizations at NIH and consider how these trends may affect the Do We Go From Here?" and Hal Varian biomedical research community. Nationally speaking on "Usage Based Charging: T hreat or The annual "walk-in" influenza immuniza­ recognized expens participating in the Salvation?" The afternoon session, located in tion progran1 of che Occuparional Medical conference include Jason Likkai Ng, a Mosaic Bldg. 31C Conf. Rms. 8 and 9 from I :30 co 4, Service (OMS) continues rhrough Nov. 18. developer from the National Cencer for consists of panel discussions that will focus on For specific days and times of the walk-in Supercomputing Applications at che Univer- "Internee Threats and Security" and "Technol- clinics, call OMS, 6-4411. 0 page4

The Record October 11, 1994

HUDSPETH REORGANIZATION moving off-campus co the Wesrwood Bldg. (Continued from Page 1) (Continued from Page 1) Over the following years, the institute scientific areas among the divisions, we will maintained a small suite of offices in Bldg. 31. Ph.D. in neurobiology and his medical degree improve the institute's ability co promote and Mose recently, the offices have been occupied from Harvard University. In addition to the support the most innovative basic research of by the institute director (who also maintained anniversary lecture, he was selected ro give the the future." an office in rhe Westwood Bldg.) and rhe Grass Lecture at chis year's annual Society for Two other institure components also become Office of Research Reports. Neuroscience meeting. Hudspeth is an divisions: the Division of Minoriry Opportuni­ All mail to NIGMS staff should now be NIDCD Claude Pepper Invesrigacor. T he ties in Research and rhe D ivision of Extramural addressed as follows: Pepper Award is Activities. (Name of staff member) given to investiga­ 'The reorganization corresponds co the policy NIGMS, NIH tors who have a objectives of the Clinton administration's 45 Center Drive MSC 6200 distinguished record National Performance Review by streamlining Berhesda, MD 20892-6200 of substantial and 'delayering' the institute and by increasing NlGMS telephone and fax numbers are contributions in supervisory/staff ratios. The new organization changing as well. Call the old number to hear research on human is nor intended to reflect changes in NlGMS a recording giving che new number, or call the communication. support for specific areas of science," Cassman N IGMS Office of Research Reports, 6-7301, to T he process of notes. "In fact, the grant portfolios managed find out an employee's new phone number. 0 hearing involves a by individual program administrators will chain of events. remain essentially the same." Normal Subjects Needed Sound waves travel Ocher changes involve modifications of A neuroimaging research project requires through the ear • / organizational names and the movement of subjects berween the ages of LS and 45. canal and cause rhe Dr. Albert}. Hudsperh several administrative offices co more appropri­ Limited radiation exposure is involved as part eardrum to vibrate. We hear when these ate organizational levels. of single photon emission computed tomogra­ vibrarions are passed through the small bones Return to Campus phy (SPECT) procedures. Study involves in the middle ear to che fluid-filled cochlea, the The move to the Natcher Bldg. brings the screening evaluation, rwo SPECT scans and snail-shaped inner ear, where the hair cells of entire NIGMS staff to the NIH campus for the one MRI scan. Payment is provided for the hearing organ move with pressure changes. first rime in more than 30 years. Around the participation in cl1e study, located on the Studying che structure and function of the time of the institute's creation in 1962, staff of campus of Sr. Elizabechs Hospital in Washing­ cochlear hair cells is difficult for scientists the D ivision of General Medical Sciences­ ton, D.C. Ample parking is available, as is because rhe cochlea and hair cells are sur­ wh ich had been located primarily in the Stone access by Metro. If interested, call Dr. Eric rounded by rhc dense bone of the skull. House-moved briefly co Bldg. 31 before Watsky, (202) 373-6112. 0 Humans are born with approximately 32,000 hair cells. These are fringed with fine hairs, N/GMS Divisions Defined in Brief called stereocilia, which convert mechanical T he Division of Cell Biology and predoctoral fellowship awards for minority impulses into electrical energy. Sounds of Biophysics supports research on the students. different frequencies and intensities move che assembly, structure, and function of cellular T he Division of Pharmacology, Physiol­ stereocilia differently, and the distinctive components using biochemical, biophysical, ogy, and Biological Chemistry attempts to patterns of electrical activity are interpreted by chemical, generic, and mathematical methods. integrate the invesrigational approaches of the the brain as variations in sound. Over time, The goal of chis research is to understand disciplines of chemistry, biochemistry, exposure to loud noise results in the loss of hair cellular components and how they interact to physiology, and pharmacology into a cells. Aging also results in the death of some maintain the function of che cell and the molecular-level understanding of fundamen­ hair cells. organism. tal biological processes, and to uncover When the scereocilia are inactive, they lean The Division of Genetics and Develop­ avenues for their control. Goals of supported together in a bundle in rhe shape of a cone. mental Biology focuses on gaining a better research include an improved understanding When they are active, their movement results understanding of the fundamental processes of drug action, new methods and targets for in a signal that is sent along the auditory nerve and mechanisms of inheritance and develop­ drug discovery, advances in natural products co the brain. Hudspeth is studying how the ment. Projeccs supported by chis division, synthesis, an enhanced understanding of hair cells' stereocilia move naturally and what which make use almost exclusively of model biological catalysis, and a greater knowledge happens when they are moved in rhe labora­ systems, provide che foundation for che design of merabolic control mechanisms and tory. For example, he has found chat the most of bette/ methods to diagnose, treat, cure, and fundamental physiological processes. minute movement of the scereocilia stimulates prevent genetic diseases in humans. Research funded by the division also fosters the nerve rhat goes ro the brain where sound is The Division of Minority Opportunities the integration and application of physiologi­ perceived. Changes rhat occur in rhe move­ in Research serves as the focal point for cal and biochemical research in addressing ment of stereocilia will help scientists under­ institute efforts co increase the number of certain clinical issues and problems such as stand how sound waves are converted into minority biomedical scientists. Its compo­ drug interactions, mechanisms of anesthesia, electrical impulses and, ultimately, how we nents include the Minority Access co Research and those char occur as a result of trauma and hear. 0 Careers Branch, which supports research burn injury. training at institutions wirh substantial The Division of Extramural Activities is Hip Replacement Revisited minority enrollments, and the Minority responsible for the grant-related acciviries of Biomedical Research Support Branch, which the institute, including the receipt, referral, A review of NIH 's recent consensus develop­ supports research projects at minority and advisory council review of applications as menr conference on total hip replacement will institutions. The division administers the well as grant funding and management. It be given by Dr. Stephen L. Gordon, director, "Bridges ro the Future" program, which maintains an overview of the institute's Musculoskeletal Diseases Branch, NIAMS, ar enhances the transition berween institutions scientific and financial status and advises the the arthritis and musculoskelecal diseases chat grant associate degrees and those that director and other key staff on policy matters interagency coordinating committee meeting grant baccalaureate degrees, as well as between and on rhe planning, development, and on Thursday, Oct. 13 from 1 :30 co 4 p.m. in master's- and Ph.D.-granting institutions. Ir scientific adminiscrarion of institute research Bldg. 31, Rm. 4C32. D also administers a program of individual and training progran1S. page 5

The Record October 11 , 1994

HARTLEY Dr. Janet Hartley, an (Continued from Page 1) unparalleled and unsung nent virologists and immunologists, including genius at growing and NIH director Dr. Harold Varmus, NIAID identifying viruses. W ith director Dr. Anthony Fauci, Dr. Peter Voge of associares like chis, no one che Scripps Research Institute, D r. Robin could fail." Weiss of the Institute for Cancer Research (in Hopkins, a one-time Hardey England), Dr. Anna Marie Skalka of rhe Fox collaborator, recalled when she Chase Cancer Center and Dr. Nancy Hopkins first met Hardey in the of MIT, all of whose work has drawn on NIAID lab: "Jan was able to Hartley's contributions to virology. participate in the conversa­ "Dr. Hardey is an immensely talenred and tion, titer the viruses, record influenrial scienrist, and a key figure in the the data, d irect the techni­ great scientific rradition ofNIAID," said Fauci. cians, smile graciously, and "Her work underpins our understanding of the always be on cop of every­ murine leukemia viruses, and her ongoing work thing. Needless to say, l was on the host and viral generic determinants of totally in awe of chis person. retrovirus-induced immunodeficiency in mice 1f there is anything I would promises to contribute co our understanding of like to pass on to my students, the pathogenesis of AIDS in humans." ir is what I learned from che One ofHartley's early collaborators war Dr. Robert]. Huebner, now "Jan's studies have won her international work of Jan Hard ey and Wally retired from NCI. Here they discuss virus research for which they recognition as one of che foremost virologists of Rowe: the integrity and received the J970 Kimble Methodology Award in Houston. our era," said Dr. Herbert "Sandy" Morse, solidness of their data, and the chief of NIA1D's Liboratory of lrnmunopa­ beauty, elegance, and imagination of their rhe most widely used cell line for growth of thology and organizer of the symposium. "Her experiments." murine leukemia viruses. acclaim and respect have resulted from a steady Among Hartley's early and most important During her career, Hardey has also character­ series of truly remarkable d iscoveries thac achievements were the development of ized murine leukemia viruses in feral (wild) opened whole new areas of investigation to techniques for the detection and quancication mice, and shown that viruses recovered in virologists." of viruses, for which only cumbersome and nature are different from chose seen in the Hardey d iscovered a number of new viruses, insensitive laboratory assays had been available. laboratory. H er studies of polyoma vi ruses including the mouse adenovirus, a rabbit In her doctoral studies ac George Washington have demonstrated that, unlike laboratory papovavirus, and che monkey cycomegalovirus. University iu the mid-1950's, she developed mice, wild m ice can be infected with polyoma The latter virus was a serious problem in the tissue culture assays for the guinea pig viruses without developing tumors. production of vaccines in monkey cell cultures cytomegalovirus, and subsequently extended "Jan's work with feral mice exemplifies the and Hartley's discovery clearly contributed to her studies to include human CMV and ocher research philosophy in Building 7-you go out safer vaccines. imporranr viruses. Her work with Rowe in and see what's happening in the real world, not She often collaborated with Dr. Robert developing tissue culture assays for murine only in an experimenral system," says Dr. Huebner, now retired from NCI, and the late leukemia viruses facilitated thousands of Robert C hanock, chief ofNIAID's Laboratory D r. Wallace Rowe during their consecucive investigations and increased u nderstanding of oflnfectious D iseases. tenures from 1953 to 1983 as chiefs of the these agents. Another of Hartley's important comribucions NIAID Laboratory of Viral Diseases. "The Hardey and her colleagues also demonstrated was the discovery of m ink cell focus-inducing truly remarkable synergy among these three char mouse sarcoma viruses only replicate in the srrains of murine leukemia viruses, which are scienciscs put che accomplishments of Building presence of another "helper virus." In ocher genetic recombinanrs between cwo classes of 7 virology at the pinnacle of science at N IH," studies, using leukemia-prone and leukemia­ endogenous murine leukemia viruses that said Morse. free strains of mice, chey generated the first appear co be directly involved in che etiology of Upon receiving a major cancer award in proof chat che blueprincs for a leukemia virus spontaneous viral leukemia. 1981, Rowe attributed his success to "falling in may be present in an unexpressed form in a Hartley told the audience, "I have been with rwo geniuses, Dr. Robert Huebner... and normal cell's genetic material. As a direct exrraordinarily lucky in my research life, and consequence of this work, have many colleagues co whom thanks are d ue." ---- researchers developed She singled our the three laboratory chief~ with techniques to manipulate whom she has collaborated- Huebner, Rowe, specific viral genes co and Morse-as individuals with the "ability co determine their effects on provide ideas and darn which widely stimulated sponcaneous, chemically or the work of others." She also acknowledged physically induced rumors in the "unstinting support, both ar the laboratory mice. and institute level, and the exceptional Hanley and her colleagues opportunities for collaboration that have long also made rhe initial been inrrinsic to NIH." discovery ofN-rropic and B­ Hardey received a B.S. degree from the tropic hose range variants of University of Maryland in 1949, and an M.S. murine leukemia viruses, and Ph.D. from George Washington University which helped clarify che in 1951 and 1957, respectively. She has served natural biology and genetic on several national and international scientific transmission of these viruses. committees and on rhe editorial board of the She subsequently derived, by journal ofthe National Cancer Institute. Among clonal selection, a highly other honors, she has received che Kimble Dr. Harold Varmu; (l), NIH director, and Dr. Robert Chanock, chief permissive cell line, nonre­ Methodology Award, che NIH D irector's ofNIA/D's Laboratory oflnfectiou; Diseases, meet with Dr. Janet strictive for N-tropic or B­ Award and che PHS Distinguished Service Hartley, chiefof the viral oncology section in NIAJD s Laboratory of tropic viruses, chat became Award. 0 Immunopathology, at a recent sympo;ium honoring Hartley. page6

The Record October 11, 1994

Research Festival, Once Again a Success "Too many rhings overl apping." "Hard ro attend all sessions." "Gave up experimenrs ro arrend ." "Very srimulatin g." "Good way ro find out whar else is going on ar NIH." "Learned a lor. " These are some of rhe commenrs mosr ofren heard from Research Festival '94 attendees who were scrambling ro get inro a parricular workshop or symposium. Mosr of the workshops filled early and it was sranding room only- thar is, if you were lucky enough co ger inro rhe room ro stand. Ask Cynthia Hinck from NIDDK, one of those sirring outside a crowded workshop. A newcomer to NIH in May, she was thrilled about the festival and had attended one symposium but was rrying ro get inco the lecture by NICHD's Dr. Jennifer Lippincorr­ committee. Schwarcz on the "Role for microrubles and kinesin in membrane traffic between rhe ER and Golgi complex." Explaining why she was through Sept. 23, which included 3 days of so disappointed, she said, "Thar is rhe general symposia (6 coral), workshops (53), and a area I work in." poster session featuring NIH intramural The festival began on Sepr. I 9 and ran research. T he week-long evenr concluded with a 2-day Scienrific Equipment Show. Even though the festival ranks as one of rhe busiest weeks at N [H, preparations began long before thar. In facr, back in March, calls went out to all ICDs inviting participarion in the , posrer session. Only 420 applicarions could be accepted so requesrs were honored on a first­ come basis. Dr. Richard Adamson, former direcror of NCI's D ivision of Cancer Eriology, •Swapan De (L) ofNIM H and Arun served as chairman of rhe organizing commit­ Chakrabarti (c) ofNIN DS Listen to tee. For rhe firsr rime, NIH recognized the Hemand Kole ofNIA explain his contribution of young scientisrs-in-rraining collaboration-in-progress with re­ from across the cou ntry at this year's festival. Clinical residents in rheir first postgraduate searchers from NHLBI andJ ohns year who had performed meritorious research Hopkins. Koles poster was categorized were inyiced ro participate. A committee of incramural scientists selected the 25 final under signal transduction, one of15 abstracts chosen for presentation. divisions for the mm·e than 300 posters De Tan (1) studies the exhibit pre­ NICHD sponsored chis year's Distinguished Alumni Symposium in which Dr. Philip Leder, under the festival tents. sented by Jong-Hoon Lee and others in a pioneer in the field of molecular generics summers as an u ndergraduate student, then research, and five ocher distinguished alumni CC's department oftransfasion lacer worked for several insritutes-NHLBI, were honored. NCI, and NICHD- before leaving in I 980. medicine. Tan also works for D TM. Leder began working for NIH during his He currently serves as che John Emory Andrus p rofessor of generics and chairman of the department of genetics at Harvard Medical School and is also a senior invescigacor with rhe Howard Hughes Medical Institute. He was presenred with the 1994 Distinguished Alumnus Award at the end of the first symposium. Visiting NIH's research festival was Dr. Elija Philip Holmes, a staff Spiva from California. Afrer viewing rhe many posters displayed in the rents during the poster fellow at NJMHfor 2 session, he probably sums up rhe general years, explains his poster feelings of mosr participants at the festival with his comments: "Inspiring. Science communi­ to Krystyna Isaacs, an cation is a good thing. This research fesriva l is - intramural research a wonderful thing ro do." training associate also The phoros on these pages represent the symposia, workshops, alumni reception and ftomNIMH poster session char comprised the festival. page7

The Record Ocrober 11, I 994

PC Topic Session Set, Oct. 18 DCRT's Distributed Systems Branch holds regular PC Topic Sessions designed to keep NIH'ers up co date on rapidly advancing PC technology. Open to all employees, che meetings follow a similar format: After DSB staff briefly relate industry and NIH PC news items of interest and entertain a few minutes of PC-related questions, i:here is a 1-hour feature presentation on a topic of general interest. Coming up on T uesday, Oct. 18, 3:30-5 p.m. in Lipsett Amphitheater, Bldg. 10, is a talk on "Borland Incernarional." The company first gained acclaim for its line of language pcoducts, which were legendary for speed. Meeting at the NICHD Distinguished Alumni Reception on Sept. 18 in the Lacer it became a force in spread sheets with Cloister are (from L) Drs. Gerald Fischbach, Shirley Tilghman, Harold Varmus, Quarcco Pro, which it recently sold to Novell, and databases with Paradox and dBASE. The William Chin, Philip Leder, Arthur Levine, Stuart Orkin and Tasuku Honjo. long-delayed release of dBASE 5 for Windows has received rave reviews, though some question whether at chis point dBASE has much chance of regaining the commanding lead it once had. Ac chis meeting, representa­ tives from Borland will demonstrate their database produces and discuss upcoming darabase strategy. D Theatre Group Plans Revue The NIH R&W Theatre Group will present Rodgers and Hart: A Crlebration on 0cc. 28, 29, and Nov. 4, 5, 11, and 12 ac 8 p.m. and Nov. 6 and 13 at 3 p.m. in Masur Auditorium, Bldg. 10. The show will be a musical revue of che music of Richard Rodgers and Lorenz Hart, including such songs as "With A Song in My Heare," "Isn't It Romantic?," "The Mose Beauriful Girl in the World," "Bewitched," Nicholas Schiff{L), 2nd-year neurology "The Lady Is a Tramp," and many ochers. Beth Hunter is directing a rnlented cast, resident under the Office of accompanied by a live orchestra. Ticker prices Educations clinical training program, are $10 for adults, $5 for seniors, and $3 for discusses his poster with Dr. Mark children 12 and under. Dr. Roland Owens, who works in The Theatre Group is an ensemble of NIH Hallett, NINDS clinical director. employees and other community members who NIDD Ks Laboratory ofMolecular each year present a musical and a dramatic and Cell Biology, was in a rush to get production for rhe benefit of the NIH Patient Emergency Fund. The group also presents into the workshop on transcriptional traveling productions of its musicals. For more regulation ofchromatin . He has been information, call Elaine, (30 I) 589-0720. D at NIH since 1985 and describes the Exam Day Has Changed research festival as "very stimulating. " NIH is changing the days ic will be giving the Clerical and Adminisuative Examination. In the past, NIH has given the exam on Monday, Wednesday and Friday mornings. Effective immediately, NIH will only give the exam on Monday and Tuesday mornings. The exam starts promptly ac 9 a.m. and is given on a flrst­ come, first-served basis to the first 16 appli­ cants. The exam is given in Bldg. 31, Rm. Elija Spiva, a visiting doctor from B3C02B. The Office of Personnel Managemenr at California, checks out NCis exhibit 1900 E St., NW, Washington, D.C., adminis­ that provided three-dimensional ters the exam on Wednesdays at 8:30 a.m. The Office of the Assistant Secretary for Health at viewing. He said NfHs research 5600 Fishers Lane, Rockville, Md., (Park.lawn festival is "inspiring. Science commu­ Leder {l) meets with Dr. Duane Bldg.) administers che exam on Thursdays and nication is a good thing. " Fridays at 8:30 a.m. For more information, Alexander, director ofNJCHD, which contact Terri Messick, 6-2404. U.S. cicizen­ hosted this years alumni reception. ship is required. 0 page8

The Record October 11 , 1994

KINYOUN LECTURE Clinical Immunology Award. NCRR Veterinary Program Gets (Continued from Page 1) T h is year, she was elecred ro che National New Acting Director from UW cyres. T his work opened rhe door fo r bio­ Academy of Sciences and also received both che O r. Melvin B. Dennis, Jr., has been chemical studies of orhcr molecules on rhc UCLA and che Sandoz distinguished professor­ appointed acting director ofNCRR's Veteri­ surface of B cells. Wirhin rhis realm, she also ships. She has trained more than 65 Ph.D. and nary Resources Program. He comes to NCRR described rhe fim lymphokinc (IL-4) char M.D. students and postdoctoral fellows and, from the University ofWashingron, Seattle, causes B lymphocyres ro undergo changes in each year since 1989, has been the recipienr of where he is an associate professor in the rhe production of rheir antibody class (lym­ rhe Faculty Teaching Award fro m department of compararive medicine. phokines are components of the immune Souchwestern's medical students. She is an During his I -year NCRR renure, Dennis system rhat are involved in the activation of rhe advocate for basic science, women in science, plans to explore the expansion of certain body's immune response). and science educarion.-Karen Leighty 0 program services such as embryo cryopreserva­ Vitetta's second area of imeresc has been the cion and pathology to meet the needs of NIH development of cancer-rreatmem compounds Workshop To Address Alopecia clients better. He also hopes ro initiate a known as number of research projects and establish new ancitumor­ NIAMS and rhe National Alopecia Arcata collabo rations wirh ancibody-coxin Foundarion are sponsoring a workshop on intramural conjugates, or . . alopecia areara, an immune-mediared disease research ers. "I 1rnmunotox1ns. causing hair loss, that will be held Nov. 7-8 in would like to She is a recognized Lister Hill Aud irorium, Bldg. 38A. promote a more leader in che field The daytime session on Nov. 7 will cake academic atmo­ of immunotoxins place from 8 a.m. to 5 p.m. and include sphere," he said. and was involved presentations o n rhe molecular and autoim­ NCRR's in the earliesr rest mune aspects of alopecia areara. A poster Veterinary tube studies of discussion and reception will cake place in che Reso urces Program these new evening from 7 ro 9 :30 at the Pooks Hill provides compre­ pharmaceuticals. Marriott. Topics will include growth factors, hensive support for D r. Melvin Dennis, Jr. Following che the immune system, histoparhology, bio­ N l H animal Dr. Ellen S. Vitetta discovery phase, chemical regulators, anim al models, and research, working with scientists conducting she revised rhe formularion of the drugs and rreacment of alopecia arcaca. animal research co select appropriate an imal then carried our studies first in mice, rhen in T he program on Nov. 8 will cake place at models, diagnose and creac disease, and meet primates, and fi nally in h umans with B-cell Lister Hill from 8 a.m. to 12:30 p.m. and will nutritional and housing requirements. The lymphoma. This work stands as a model for focus on hair follicle biology. program also manages the N IH Animal rhe translation of basic science to the clinical For more information or co register, call Genetic Resource, which mainrains a breeding setting. Also significant was the facr rhat this Judith Wortman, 6-8 190. 0 colony of more than 350 rodent and rabbit work was accomplished entirely rhrough rhe strains. T hese are used as animal models by cooperation of academia and NIH. Quartet Performance Planned invesrigarors ar NIH and around the world. Vi cetta began her academic career at Smith Dennis earned his bachelor of science degree College and continued at Connccricur College, A concert of suing quarters will be per­ and D.V.M. ar Washington State U niversity in where she received her B.A. degree in 1964. fo rmed by the N IH Chamber Players (Morton Pullman. Afrer serving 2 years in the U.S. She went on to New York University graduate Raff, Grace Baeringer, Jere Stern and Suzanne Army Veterinary Corps as commanding officer school, obraining her M.S. in 1966 and her Epstein) at noon on Wednesday, Oct. 26 in of the 79th medical derachmenc, he entered Ph.D. in 1968. Her posrdoctoral fellowship, Masur Auditorium, Bldg. 10. String quarters privare veterinary practice. He joined rhe which she completed in 1970, was taken ar of Beerhoven and Shostakovich will be on the University of Washington in 1971, and New York University School of Medicine, program. The special events section of the remained there until his NCRR appoin tment. where she stayed as assistant research scientist Clinical Center will sponsor the evenr. T he He is a diplomate of rhe American College of and, from 1971 co 1974, as assistant professor concert is free and all are welcome. For more Laboratory Animal Medicine and a found ing of microbiology and associate research scientist. information call (301) 897-5463. 0 member and pasr president of the Academy of Vicecra began at the University of Texas Surgical Research. D Southwestern Medical Center in 1974, when LASKER AWARD WINNERS ARE NIH GRANTEES she accepted rhe position of associate professor (Continued from Page 1) of microbiology. She became the youngest full Research Award for discovering the role of lung surfactant in normal lung fu nction and later professor at Souchwestern's medical school in developing an artificial lung surfacrant now used ro save lives of premature infants around the I 976. In addition ro her present position as world who were dying from respiratory distress syndrome (RDS). Clements' synthetic agenr is director of che school's Cancer Immunob iology credited wirh curting rhe annual death rare from RDS by 50 percent; and Or. Maclyn McCarty, Center, she has held che Scheryle Simmons who earned the Special Public Health Award for his groundbreaking work in discovering that Pacigian distinguished chair in cancer DNA is the chemical substance of heredity, wh ich preceded by a decade the Nobel Prize-winning immunobiology si nce 1989. contributions of)ames Warson and Francis Crick char revealed the structure of che DNA Viretta is rhe current president of the molecule. T he award, which chis year recognizes rhe 50th anniversary of McCarty's achievement, American Association of Immunologists and a has only been given four other times in rhe Lasker Awards' 49-year history. member of che advisory board of che Howard Prusincr is a professor of neurology and biochemistry at the Universiry of California, San H ughes Med ical lnsrituce, besides her active Francisco. His NlA and NINOS funding history began in 1972 and is currently projected association wirh a number of other professio nal rhrough 1998; he has garnered 73 grants worth jusc over $38 million. o rganizations. She has served on the editorial Clements is a professor of pediatrics at UCSF. His studies of lung function have been supported boards of many journals, including the Annual by NHLBI since 1975, roraling 20 grants worth almost $23 million. Review ofImmunology, the Journal ofImmunol­ McCarty is professor emeritus at rhe Rockefeller University. His NHLBI and N IGMS funding ogy, and Cancer Research, in addition ro being history commenced in 1959 and ended in 1981, totaling 31 awards worth just over $2.6 million. editor-in-chief of Therapet,tic l mmunulogy. In This is the 47rh year rhat Albert Lasker Medical Research Awards have been given since they 1991, she received the FASEB Excellence in were firsr presented in 1944. Over the years, 51 winners have subsequently won Nobel Prizes. Science Award and, in 1992, the Abbocr Each Lasker winner receives a $25,000 honorarium, a citation, and an inscribed statuette. D page 9

The Record October 11, I 994

STETTEN NIEHS Retiree Rodbe/1 Named &Scientist Emeritus' (Continued from Page 1) Schreiber is using approaches and techniques Following a distinguished career of 38 years He has also carried our a number of from the fields of chemistry, biochemistry, at both the Bethesda and NIEHS campuses, pioneering studies on the actions of hormones molecular and cellular biology, and srrucrural Dr. Martin Rodbell has been granted the ride in the liver. Ir was in the course of his work biology to define some of the fundamental of scientist emeritus. This honor is accorded with glucagon, a hormone that reverses the fearures of signal rransducrion pathways. to selected individuals who have served in an effects of insulin, that he discovered the Among his major findings is char rhe binding of exemplary capacity during their careers in the importance of guanine nucleotides in a key proteins called immunophilins to natural NIH intramural programs, and who wish to signaling sequence chat helps regulate cell products-based immunosuppressanr drugs plays continue their research after retirement. growth and activiry. This discovery provided a role in signal transduction in the immune Since 1985, Rodbell has held rwo positions the first evidence for a biochemical entity sysrem. within the called the GTP-binding protein, or G­ institute, first as This research led to the idenrificarion of protein. Today, a large family of G-proteins is cellular targets of immunophilin-immunosup­ scientific director, known to regulate such diverse functions as pressant complexes and has shed light on how and then as chief adenylyl cyclase activation, phospholipase C, of the section on immunosuppressanr drugs work. A recent membrane ion channels, protein synthesis, extension of this research may eventually make signal transduc­ and cellular growth and differentiation. tion until his i r possible to regulate the expression of inserted Rodbell followed his discovery of the signaJ genes, which could increase rhe uriliry of gene recent retiremenc. rransducing function of guanine nucleotides rherapy methods. The priviJeges with continued work on the nature and Schreiber will present his work at this year's gran red to him as mechanism of G-prorein acrion in cells. He scientist emerirus, described both srimularory and inhibitory which include use effects of guanine nucleotides, findings chat of an office and eventually led to the discovery of inhibitory laboratory, and Dr. Martin Rodbel/ G-proteins. i nscicu re library The impact of his work on the scientific and computer services, will enable him to community is evident in the many ways he continue his work in understanding signal has been recognized by his peers. He has transducrion mechanisms. served on a number of editorial boards, Rodbell's early work resulted in important including the journal ofBiological Chemistry, findings on the structure and metabolism of Advances in Cyclic Nucleotide Research, and the lipoproteins and chylomicrons, sma!J lipid American Journal ofPhysiology . In addition to particles chat appear in the blood after being a member of the National Academy of ingestion of fat. He then developed tech­ Sciences, Rodbell has received numerous niques for isolating and studying adipocyte national and international awards, including "ghosts," physiological membrane prepara­ rhe Gairdner International Award, the tions that have greatly facilitated scientists' Richard Lounsberry Award, and an honorary investigations of the actions of hormones at docrorate from Montpelier University in France. Dr. Stuart L. Schreiber the molecular level.

DeWitt Stetten, Jr. Lecture. The lecture, which focuses on the discovery of therapeuric Extramural Grantsmanship entitled "A Chemical Approach co Understand­ agents that modulate intracellular signaling Workshop Set, Oct. 27 ing and Controlling Signal Transduction," will pathways by combining the disciplines of A workshop on extramural programs and be given on Wednesday, 0cc. 19, at 3 p.m. in organic chemistry, molecular cell biology, and grant support, designed co help postdoctoral Masur Auditorium, Bldg. 10. Sign language srrucruraJ biochemistry. More recently, he fellows understand the research grant process, inrerpretarion will be available if needed. cofounded ARIAD Gene Therapeurics, which will be held on Thursday, Oct. 27, from 8:30 Schreiber received a B.A. in chemisrry in is arrempring to develop a reguJated approach a.m. to 5 p.m. in Masur Auditorium, Bldg 10. 1977 from the University of Virginia, and a ro human gene therapy using synthetic, orally The workshop, sponsored by the National Ph.D. in organic chemistry in 1981 from active agents. l nstirnre of General Medical Sciences, is Harvard Universiry, where he worked under The Sretten Lecture, which is sponsored by intended for intramural postdoctoral fellows, rhe supervision of Nobel laureare Dr. Robert B. NIGMS, honors Dr. DeWin Scecren, Jr., the staff fellows, clinical associates, and research Woodward and Dr. Yoshiro Kishi. He then third director of che institute. He had a strong associates who are planning to leave NIH and joined the chemisrry depanment faculty of Yale commitment co basic research, especially in the will be preparing research grant applications in Universiry, where he was promoted to associate areas of generics, cellular and molecular the future. professor with tenure in 1984 and to full biology, and chemistry. The workshop will cover the NIH peer professor in 1986. He returned to Harvard in NIGMS has supported Schreiber's work for review process, tips on preparing a grant 1988. the past 12 years. D application, programs available for new Among his many honors and awards are: the i.nvesrigators, and the names of appropriate Ciba-Geigy Drew Award for Biomedical NIMH Seeks Volunteers people to contact witb problems or questions. Research, 1992; the Rhone-Poulenc Silver Small group discussions designed to answer Medal, Royal Society of Chemistry, 1992; and NIMH is seeking volunteers 40 years or inclividual questions will be led by experienced the Paul Kerrer Gold Medal, 1994. The older to participate in studies of menopause­ staff from the Division of Research Grants and American Chemical Society has honored him related hot flushes. Volunteers must be several ocher NIH components. with four of its most prestigious awards, as medication-free, including hormonal replace­ Attendance wi ll not be limited as in the past, well. ment. Hormonal evaluation will be per­ although preregistration is recommended. The Schreiber is the cofounder and coeditor of a formed, and paymem is provided. For deadline for preregistration is Oct. 24. new journal, Chemistty and Biology. He is also information, call Jean Murphy or Nazli Haq, For more information or to preregister for the a founder ofAR IAD Pharmaceuticals, Inc., 6-9675. D workshop, call 4-7762. 0 page 10

The Record Ocrober 11 , 1994

The NIH Life Sciences Education Connection esearch Festival '94 is now history. The Office of Science Education Policy cosponsored a R poster entitled, "Scientists and Life Sciences Education: Parmerships and Possibilities." Thanks go to all chose who stopped by on Sept. 19. The poster consisted of five panels, each highlighting a differenr office or program. The panels featured NCRR's Minority High School Studenr Research Apprenrice­ ship program, NICHD's Adopt- a-School program, Adventure in Science, Science Alliance, and che Office of Science Education Policy, which runs several programs including Biomedical Research Advance­ mem: Saturday Scholars (BRASS), Mini-Med School, Science in che Cinema, and the Science Education Luncheon Connection. The poster session provided an excellent forum to showcase and promote science education efforts on che NIH campus. For chose interested in volunteering, we provided a listing of opportunities. The Office of Educatio11, also integral co science education, had a separate booth nearby highlighting its programs. Dr. Irene Eckstrand, who operates Science Alliance, notes chat scientists can gee a lot our of the volunteer experience beyond the fulftllmenr of ethical and professional obligations. Eckscrand says chat scientists have commented that after volunteering with children, they go back to the lab with a renewed sense of energy and creativity; they arc able ro see their roles in an exciting way, the way in which the kids view chem. Eckscrand also says the volunteer scientists experience a feeling of genuine appreciation and admiration from che children. Betty Fleming has been named NIAID '.r EEO If you are a scientist who is interested in volunteering, many programs still need help. For more officer. A native ofPhiladelphia, she comes to information, comacr che Office of Science Education Policy, 2-2469. Those specifically incerested NIH from the Office ofPersomiel Management, in Science Alliance may comacr Eckscrand directly, 4-7762. Adventure in Science also needs where she served as a personnel management volunceers. T he coordinator for chat program is Dr. Edward Max, who can be reached at 2- specialist since 1988 and directed the agency's 0484.-Ellcn Orjala 0 Federal Equal Opportunity Recruitment Program. Prior to that appointment, she worked NHLBI Unveils Communi_ty Outreach Program as a special emphasis program manager at David NHLBI recencly initiated the first scage of its new action plan co develop hearc-healrh promotion Taylor Research Center, a naval laboratory in efforcs with rhe Washington, D.C., Latino popularion. The instirure broughc togecher more than Carderock, Md., where she design.ed and 30 represencatives from area health clinics, hospitals, communiry groups, media organizacions and developed a pamphlet on the prevention ofsexual local governmenc for a lively, day-long discussion at che first meeting of the "Community Alliance harassrnerit. She also received an award from Working fo r Heare Healch" held ac che Festival Center in Adams Morgan. the center for a successful program for people Dr. Claude Lenfant, NHLBI direccor, addressed the alliance membership, "Through chis with disabilities. partnership, we can work rogether ro reduce rhe enormous burden of death and disability from cardiovascular disease in this community. The insricute recognizes che need co engage rhe Latino community in order ro ensure rhe appropriateness and ulrimace success of this effort." The purpose of rhe projecc is ro conduce a cardiovascular disease awareness-raising campaign for a IX9f Training Classes largely overiooked segment of rhe community. The Latino population in rhe Washington metropolitan area is unique: while 24 percent of the Hispanic residents are of Mexican or Puerto I ntroducrion to the Helix Systems 10/13 Computational Challenges of the Rican origin, a majority come from Central and South America. This population is also rapidly Protein Folding Problem l 0/14 growing; it doubled in size from 1980 to 1990. Gctt;ng Started with Windows 10/17 T he project will be planned and produced in cooperation with the "Community Alliance" over Getting Started with C 10/17 - 10/20 the coming year, with a launch scheduled for September 1995. The campaign will have a mass Introduction to WYLBUR 10/17- 10/28 media component with messages appearing on television, radio and in the Latino newspapers, and Network Services 10/18 a community outreach component comprised of various health education materials and accivities. Pbnning and Installing a LAN 10/18 PC Topic Session 10/18 If chis community campaign is successful, NHLBJ hopes co transport the model to ocher Latino QMF: D82's Query Management communities around the nation. Facility 10/18 - 10/20 PC Viruses 10/19 Supercomputing on the Incerne( 10/20 Database Technology Seminar 10/21 I ntroducrion ro the BASIC Computer Language 10/21 Using Image 1.53 for Densitometric Analysis of 1-D Gels 10/25 Preview of the SAS System for Windows 10/2~ Unix Commands 10/25 DCRT Support for Unix Work.starions at NIH I 0/25 Easy Statistical So~warc for Windows 10/26 Marhcmarical Modeling with MATLAB l 0/26 -I 0127 Perspectives on Management in the NIH Technical Environment: Organizing Chaos 10/26 Drawing Pedigrees with PedDraw for ,he Macintosh Hands-On Lab 10/27 ENTER MAIL- rhe Electronic Mail NHLBI director Dr. Claude Len.font (c), with members ofthe Community Alliance Working far Sysrem on rhe Mainframe 10/27 Heart Health and NHLBI staffat the Festival Center in Washington, D. C. page 11

The Record October 11 , 1994

Top NCI Doc Hops to Pop Spot 'Topping Out' Ceremony for NIEHS Lab Module Held After more than 30 years of service co the 1963. He has remained at che institute since governmenr, Dr. Richard H . Adamson lase rhen, with two brief excursions, one ro go to When I 00 or so construction workers came month retired as direccor ofNCl's Division of London on a Fulbright scholarship in 1965-66 down off che concrete frame of che 4-srory Cancer Etiology. He has accepted an appoinr­ and co serve as a laboratory tower thac will eventually be the menr as vice president for scientific and senior policy NIEH S "F" Module and Magnetic Resonance technical affairs at the National Soft Drink analyst for rhe Imaging facility at lunchrime on a beautiful Association in Washingcon, D.C. Office of Science day recently, there was more than rhe usual bag During his time at the National Cancer and Technology lunch and thermos awaiting chem. Insticuce, Adamson went from a senior Policy at che On rhe porch of the construction sice trailer investigator in 1963 co director of the division White House in offices, a p odium had been sec up wich chairs 17 years later. 1979-80. for gathered dignitaries. After a brief explana­ T he best pare of his time here? T he people, An important tion of rhe "ropping out ceremony," a pine tree of course, b ur in more ways than one. part of his work and American Rag were placed at the highesr "Researchers here are some of the highest has been ro serve as point on the building under construction, caliber peopl e scientifical ly and intellecrually," a liaison co denoting that the concrete and steel frame of says Adamson, who applauds rhose who cook researchers in rhe building is complete. Final completion of the understanding of what causes cancer from Japan. Adamson che module and attached MRI facility is the level of a "black box" roan "archiceccural served borh as head Dr. Richard Adamson scheduled for July 1996. map" that needs only co be filled in. ofrhe NCI-Japan William P. Lefebvre, master-of-ceremonies H e also enjoyed having che oppormniry co Cooperarive for chc event and project manager for Marshall bring young researchers into his field of special Cancer Research Program and the NCI-Japan Contractors Inc., ge neral concracrors for che interest-carcinogenesis research-and co Comprehensive JO-Year Scracegy for Cancer project, explained that the pine tree was not a government service. Some of rhe most far­ Control. cur tree usually used in these ceremonies, but a reaching actions of his tenure have been che He has been honored numerous times, and live tree chat will lacer be planted near the interactions and collaborations he fostered was featured on the cover of rhe journal Cancer module to reAecr che environmental mission of between chose sciencists working on laboratory Rmarchon Sept. 15, 1993. che institute. research and those in epidemiologic studies. In his new position at rhe National Soft The topping out was follo,ved by remarks "These researchers weren't talking co each Drink Association, Adamson will be in charge from several speakers. orh er," he explained, and now rheir coUabora- of keeping cabs on research issues from water James Roberson, presiden r of che Research

"I never met a soft drink I didn't like."

purity to new artificial sweeteners and technical concerns such as produce tampering and nutrient labelin g. "I always envisioned a second career, and the Soft Drink Associarion was a good opportu­ n ity," he says. " Ir represents a produce rhac l use and with which I am very comfortable." When questioned abour his favorite beverage, though, he simply says, "I never met a soft drink I didn't like."-Kara Smigel 0 Topping out ceremony involves placing a tree and banner at the highest point ofa structure 1mder NIA Funds PBS Menopause Show construction. Here at the NIEHS F Module, an Adamson wore an Ebenezer Scrooge costume to a American flag and live tree, to be replanted later holiday party in 1988. T he National Institute on Aging has at the site, commemorate this landmark in the supported What's New About Menopause, a completion ofa new kib tower. cions are common practice. television special to be broadcast on PBS Bue Adamson says cha r che everyday people Tuesday, Nov. I at 8 p.m. Triangle Foundation thar serves as landlord for at NCI were the best pare of his service. T he show, pan of PBS' NOVA sedes, now in Research Triangle Park, commented rhat He especially appreciated being able ro "acr its 21st year, examines d1e stories of women NIEHS, along with IBM, as newly arrived up a bit" at Halloween and the winter confronting " the change," an ex.perience chat tenants in 1965, provided institutional anchors holidays, when he would dress up as a goblin, will affect more rhan 20 million American for the park char now boasts more than 14 witch, or visir che Office of che Oirccror women in the nexr decade. million square feet of office, lab and 0th.er holiday party dressed as Sama or a very tall The show was produced by rhe WGBH work space. green elf, among ocher guises. science unit in association with the New W hen the speakers were done, everyone was Adamson was a commissioned officer for the England Research I nscicurcs, with support from invited ro fi le past a table for souvenir T-shirrs Public Health Service fo r 2 years, from 1961 to NIA. Ir was wrirren, produced and directed by commemorating the copping our ceremony, 1963, which broughr the Iowa-born and - Denisce Dilanni of the NOVA sraff, and is and on roan area within the concrere structure educated researcher co rhe D.C. area. He narrated by actress Stockard Channing. Check for a "pig pickin'," a picnic featuring a switched to civil service and a career ar NCI in local listings for a possible change in air dare. D barbecue pork and chicken buffet. D page 12

The Record October I I , 1994

AIDS Activists Honor NIAID's DAIDS Staff By James Hadley s the war against AIDS conrinues, layers A of frustration have built up for all concerned-activists, patients, their families, friends, physicians and researchers. However, recently rhese frustrations were set aside rn salute some of the people who carry on rhis war inside rhe federal government at NWD. Project Inform, a national H IV/AIDS advocacy organization based in California, honored NIAID's Division of AIDS (DAIDS) with the Martin Delaney Research Award ar its first annual awards dinner in Beverly Hills. Calling it a special honor, Delaney, the founding direcrnr of Projecr Inform, said the award was for rhe DAIDS srnff who have dedicated rheir lives and careers co the AIDS battle. These individuals, said Delaney, "so At a recent dinner in Beverly Hills, Dr. Jack Killen, director ofNIAID Division ofAIDS and Dr. often feel the sting of public criticism-because s Margaret I. }ohmton (r), acting deputy director, DAIDS, join other recipients ofawards from Project AIDS is still with us- yet are so seldom Inform, a national HIV/AIDS advocacy organization. Also shown are (from I) actress Swoosie Kurtz, thanked for their many accomplishments and singer-actress Nell Carter and model-actress Kathy Ireland. tireless commitment as individuals. We appreciate you all- scientists, doctors, nurses, adminisuarnrs, technicians, budgereers, and largely unheralded group of people in science working rogecher. managers, and all chose whose clerical and NIAID have dedicated themselves co chis "The richness of our relationship with Project administrative support make the science batcle with as much eagerness, dererminacion, Inform has certainly included its share of possible. We could have never come this far and commitment as any activist on chis disagreement, sometimes vehement, but always without you. planer." choughr-provoking and productive," he added. "It is no secret that people with AIDS and Accepting the award on behalf of the "While we stiU have a long way rn go in a AIDS activists h ave been discontent with the division, Dr. Jack Killen, director ofDAIDS, tremendously complex and challenging efforts of the federal government co end the noted chat rhe award was extremely special, endeavor, Project Inform has gained the respect AIDS crisis," said Delaney. "No matter how coming from Project Inform, "one of our and admirarion of the biomedical research critical we activists have been about the effort in roughest and best critics. Project Inform has community, and will continue to be an general, we cannot help bur recognize chat we served as vigilant reminder that our first loyalty important force for the good." are nor rhe only ones who care about ending in the research enterprise is co people with or Project Inform also honored actresses Nell this epidemic, not the only ones who have lose at risk of acquiring HIV infection, as a Career with the activism award, Kathy Ireland loved ones, and not rhe only ones waging chis stimulus to more creative research, and as an with the education award, and Swoosie Kurtz battle. For the past decade a caring, competent, example of the power of community and with the tolerance award. D

HIV/AIDS Training Continues, 74 Additional Sessions Planned Next Director's Seminar Set Last March, NIH direcrnr Dr. Harold Montana as well as rn those ac Sr. Elizabechs The second speaker in the 1994-1995 Varmus announced NIH's plans rn provide Hospital in Waslcingcon, D.C., and at Fr. season of the NIH Director's Seminar HIV/AIDS ln The Workplace Training for all Detrick in Frederick, Md.) Series will be Dr. David Armstrong. He NIH employees. In his desk-rn-desk letter, he Twenty-eight nonsupervisor training sessions will speak on "New Signalling Pathways for stared, "The NlH plays an essential role in the will be held in Wilson Hall and Masur Ion Channel Regulation by Neuropeprides" nation's battle against HIV/AIDS, and the Auditorium, while 46 ocher sessions for on Friday, Oct. 28 at noon in W ilson Hall, health of our own employees is of utmost supervisors and managers will rake place at Bldg. 1. importance. We all share in the responsibility Executive Plaza South. for maintaining a safe, health ful, and produc­ NIH also plans co offer a special training tive work environment where all employees are program for those intramural scientists and NIDCD Seeks Stutterers created fairly and without discrimination." senior administrative staff who already have in­ The voice and speech section, NIDCD, is By Sept. 30, more than 11,000 NIH depth knowledge of HIV transmission and seeking persons who stutter co volunteer for a employees had completed training sessions chat biology. This program will be announced rn re.search study of two medications affecting rhe are jointly sponsored by the NIH Office of rhe NIH scientific community lacer this fall levels of different neurocransmiccers, dopamine AIDS Research and the NIH Training Cenrer. and will focus on workplace issues and and seroronin, in the brain, and how chey Participants were encouraged co share che challenges, workplace policies, and what health might affect levels of fluency. Sought are information gained at these training sessions professionals can do to dispel common myths, people who are in good health, who have no with their families, friends, and communities. educate coworkers, and disseminate valuable history of seiwres, or heart problems, or liver Both OAR and the Training Center have information in cheir communities. and kidney d isease, or glaucoma, and who received positive comments on the program as Desk-to-desk flyers will soon provide specific currently are nor cakin g any medications. The well as suggestions for enhancement, which course and registration information abour study also seeks persons who have readily have been incorporated on a continuing basis courses scheduled chrnugh December. observable levels of dysfluency. 1f accepted, since the program began in May. Employees are encouraged co contact their ICD volunteers must be seen once every 3 weeks for Beginning on 0cc. 18, 74 additional sessions HIV/AIDS rraining coordinator to find out a total of seven visits, which occur berween will be offered on campus. (Also in October, about available sessions and register now. If Monday and Friday. Ifinceresced, ca ll Dr. off-site sessions will be conducred for you don't know the name of your coordinarnr, Sheila Srager, 6-9365. 0 employees in North Carolina, Arizona, and call 6-3115 or 2-3392 for this information. 0