Cancer Research OFFICIAL JOURNAL OF THE AMERICAN ASSOCIATION FOR CANCER RESEARCH
American Association for Editor-in-Chief Cancer Research, Inc. Carlo M. Croce Publications Staff Managing Editor Associate Editors Margaret Foti Stuart A. Aaronson Benoit de Crombrugghe Waun Ki Hong Beatrice Mintz Martha R. Stampfer Assistant Managing Editor Martin D. Abeloff Riccardo Dalla-Favera Tasuku Honjo Malcolm S. Mitchell Eric J. Stanbridge Mar3.' Anne Mennite Jerry M. Adams Richard L. Davidson Kay Huebner Sharon B. Murphy GaD' S. Stein Manager, Editorial Services David S. Aiberts Eugene R. DeSombre James N. Ihle Ruth J. Muschel Bernard S. Strauss Heide M. Pusztay Carmen J. Allegra T. Michael Dexter John T. lsaacs Yusuke Nakamura Louise C. Strong Editorial Assistant Frederick R. Appelbaum Ralph E. Durand Mark A. Israel Garth L. Nicolson Takashi Sugimura Lisa A. Frank James O. Armitage Alan Eastman Elaine S. Jaffe Kenneth Nilsson Saraswati Sukumar William M. Baird Gertrude B. Elion Rakesh K. Jain Susumu Nishimura James A. Swenberg Supervisor~ Manuscript Allan Balmain Lois B. Epstein Peter A. Jones Jeffrey A. Norton Paul Talalav Processing - Margaret A. Pickeis J. Carl Barrett Leonard C. Erickson V. Craig Jordan Peter C. Nowell Tadatsugu Taniguchi Renato Baserga Emmanuel Farber Robert S. Kerbel Kenneth Olden Steven R. Tannenbaum Assistant Supervisor. William T. Beck Nelson Fausto Young S. Kim Gilbert S. Omenn Masaaki Terada Manuscript Processing Theresa A. Griffith Thomas L. Benjamin Eric R. Fearon Kenneth W. Kinzler Richard J. O'Reilly Kenneth D. Tew Joseph R. Bertino Isaiah J. Fidler Tadamitsu Kishimoto Robert F. Ozols Snore S. Thorgeirsson Editorial Secretaries June L. Biedler Robert A. Floyd Alfred G. Knudson. Jr. Michael A. Palladino, Jr. Donald J. Tindali MaR' Ellen Pirring Valerie L. Taylor Gianni Bonadonna Judah Folkman Kurt W. Kohn Peter L. Pedersen George J. Todaro Andrea Conrad Ernest C. Borden Kenneth A. Foon Laurence N. Kolonel Anthony E. Pegg Jeffrey M. Trent G. Tim Bowden Joseph F. Fraumeni. Jr. Donald W. Kufe Angel Peilicer Giorgio Trinchieri Administrative Staff Norman Breslow Errol C. Friedberg John S. Lazo Frederica P. Perera Takashi Tsuruo Executive Director Edward Bresnick Stephen H. Friend Brigid G. Leventhal Bice Perussia Axel UIIrich Margaret Foti Samuel Broder Minoru Fukuda Jay A. Levy Sidney Pestka Peter Vaupel Associate Director of Ronald N. Buick Philip Furmanski Frederick P. Li Gordon L. Phillips Giancarlo Vecchio Administration Paul A. Bunn. Jr. Eugene W. Gerner Victor Ling Cecil B. Pickett Ellen S. Vitetta Adam D. Blistein C. Patrick Burns Leo E. Gera~'eck Lance A. Liotta Jacalyn H. Pierce Daniel D. Von Hoff Senior Accountant Fernando Cabanillas Eli Glatstein Martin Lipkin Vito Quaranta Michael D. Waterfield Anthony P. Blengino Bruno Calabretta David W. Golde Marc E. Lippman Frank J. Rauscher Ill Lee W. Wattenberg Financial Assistant Eli Canaani Michael M. Gottesman Gerald Litwack Donald J. Reed Ralph R. Weichselbaum George L. Moore Robert L. Capizzi J.W. Grisham Leroy F. Liu Ralph A. Reisfeld I. Bernard Weinstein Meetings Coordinator Webster K. Cavenee F. Peter Guengerich Lawrence A. Loeb Richard A. Rifkind Bengt Westermark Jeffrey M. Ruben Bruce A. Chabner Sen-itiroh Hakomori Dan L. Longo Leslie U Robison Raymond L. White Meeting l/lanner Yung-chi Cheng Philip C. Hanawalt Reuben Lotan Igor B. Roninson Gordon F. Whitmore Carole Kanoff Bruce D. Cheson Curtis C. Harris David B. Ludlum Howard 1. Scher Max S. Wicha Public Information David Coicher Jules E. Harris Tak W. Mak Robert T. Schimke Walter Willett Coordinator Robert U Comis John C. Harshbarger Michael J. Mastrangelo J. Schlessinger H. Rodney Withers Jenny-Anne Horst-Martz Allan H. Conney Stephen S. Hecht Lynn M. Matrisian Stuart F. Schlossman Sheldon Wolff Executive Assistant for Neal G. Copeland CarI-Henrik Heidin W. Gillies McKenna Manfred Schwab Stuart H. Yuspa Programs Joseph G. Co~' Samuel Hellman Anna T. Meadows Joseph V. Simone Harald zur Hausen Ruth E. Fortson Jeffrey Cossman Brian E. Henderson John Mendelsohn Francis M. Siromak Administrative Assistant Frank Costantini Russell Hilf Christopher J. Michejda Anna Marie Skalka Robin E. Felder William M. Crist Richard B. Hochberg John D. Minna Michael B. Sporn Systems Specialist Lydia I. Rodriguez Cover Editorial Board Secretary Sidney Weinhouse. Nancy H. Colburn George H. Hitchings Takashi Sugimura Malika L. Wright Cover Edttor Hugh J. Creech Edwin A. Mirand John H. Weisburger
Editorial Secretary Cancer Research is sponsored by the American Association for Cancer Research, inc. and receives major support from the American Cancer Diana F. Certo Society. Inc. Publication costs are also met by a grant from the Elsa U. Pardee Foundation.
Subscription Information Cancer Research is published twice a month, one volume per year, by the American Association for Cancer Research, Inc. Subscriptions include the Pr~'eedings of the American Association for Cancer Research, issued in March of each year. Except for members of the American Association for Cancer Research, all subscriptions are payable in advance to Waverly, Inc., 428 E. Preston Street, Baltimore, MD 21202-3993, to which all business communications, remittances (in United States currency or its equivalent), and subscription orders should be sent. In Japan, send orders and inquiries to (sole agent): USACO Corporation. Tsutsumi Bldg., 13-12, Shimbashi-chome, Minato-ku, Tokyo 105, Japan: Tel. (03) 502-6471. Nonmembers of the American Association for Cancer Research within the United States may subscribe to Volume 54 (I 994) of Cancer Research at the rate of $415.00 (individual and institutional nonmembers), including postage. Institutional and individual nonmembers outside of the United States should add $60.00 to their respective rates to offset second-class postage costs. Canadian subscribers should add 7% GST. Air mail and other means of delivery are available at extra charge: contact Waverly, Inc. for information. Changes of address notification should be sent 60 days in advance and include both old and new addresses. Member subscribers should send address changes to: Member Services, American Association for Cancer Research, Inc., Public Ledger Building, 620 Chestnut St., Suite 816. Philadelphia, PA 19106-3483. Nonmember subscribers should notify Waverly, Inc. of changes of address. Copies of the journal which are undeliverable because of address changes will be destroyed. Printed in the U.S.A.