ETHYL DICHLOROARSINE CAS Number

Common Name: ETHYL DICHLOROARSINE

CAS Number: 598-14-1 RTK Substance number: 0871 DOT Number: UN 1892 Date: March 2000 ------

HAZARD SUMMARY * Ethyl Dichloroarsine can affect you when breathed in and * Exposure to hazardous substances should be routinely by passing through your skin. evaluated. This may include collecting personal and area * Contact can irritate the skin causing a rash, burning, air samples. You can obtain copies of sampling results itching, thickening and color changes. from your employer. You have a legal right to this * Ethyl Dichloroarsine can cause severe eye irritation and information under OSHA 1910.1020. burns leading to permanent damage. * If you think you are experiencing any work-related health * Breathing Ethyl Dichloroarsine can irritate the nose and problems, see a doctor trained to recognize occupational throat. Long term exposure can cause an ulcer or hole in diseases. Take this Fact Sheet with you. the “bone” dividing the inner nose. * Breathing Ethyl Dichloroarsine can irritate the lungs WORKPLACE EXPOSURE LIMITS causing coughing and/or shortness of breath. Higher The following exposure limits are for Arsine: exposures can cause a build-up of fluid in the lungs (pulmonary edema), a medical emergency, with severe OSHA: The legal airborne permissible exposure limit shortness of breath. (PEL) is 0.05 ppm averaged over an 8-hour * High exposure can cause poor appetite, a metallic or garlic workshift. taste, nausea, vomiting and stomach cramps. * High or repeated exposure may damage the nerves causing NIOSH: The recommended airborne exposure limit is weakness, "pins and needles," and poor coordination in 0.0006 ppm, which should not be exceeded at arms and legs. any time. * Ethyl Dichloroarsine in the presence of acid or acid mist may release a VERY DEADLY gas - Arsine. CONSULT ACGIH: The recommended airborne exposure limit is THE NEW JERSEY DEPARTMENT OF HEALTH AND 0.002 ppm averaged over an 8-hour workshift. SENIOR SERVICES HAZARDOUS SUBSTANCE FACT SHEET ON ARSINE. WAYS OF REDUCING EXPOSURE * Where possible, enclose operations and use local exhaust IDENTIFICATION ventilation at the site of chemical release. If local exhaust Ethyl Dichloroarsine is a colorless liquid with a biting, ventilation or enclosure is not used, respirators should be irritating or fruit-like (when diluted) odor. It is used as a worn. poison gas in the military. * Wear protective work clothing. * Wash thoroughly immediately after exposure to Ethyl REASON FOR CITATION Dichloroarsine and at the end of the workshift. * Ethyl Dichloroarsine is on the Hazardous Substance List * Post hazard and warning information in the work area. In because it is cited by DOT and EPA. addition, as part of an ongoing education and training * Definitions are provided on page 5. effort, communicate all information on the health and safety hazards of Ethyl Dichloroarsine to potentially HOW TO DETERMINE IF YOU ARE BEING exposed workers. EXPOSED The New Jersey Right to Know Act requires most employers to label chemicals in the workplace and requires public employers to provide their employees with information and training concerning chemical hazards and controls. The federal OSHA Hazard Communication Standard, 1910.1200, requires private employers to provide similar training and information to their employees.

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This Fact Sheet is a summary source of information of all MEDICAL potential and most severe health hazards that may result from exposure. Duration of exposure, concentration of the Medical Testing substance and other factors will affect your susceptibility to Before beginning employment and at regular times after that, any of the potential effects described below. for those with frequent or potentially high exposures, the ------following are recommended:

HEALTH HAZARD INFORMATION * Exam of the nose, skin, eyes and nervous system. * Test for urine Arsenic. This is most accurate at the end of Acute Health Effects a workday. Eating shellfish or fish may elevate Arsenic The following acute (short-term) health effects may occur levels for up to two days. At NIOSH recommended immediately or shortly after exposure to Ethyl exposure levels, urine Arsenic should not be greater than Dichloroarsine: 100 micrograms per gram of Creatinine in the urine.

* Contact can irritate the skin causing a rash, burning and After suspected overexposure, repeat these tests. Also itching. examine your skin periodically for abnormal growths. Skin * Ethyl Dichloroarsine can cause severe eye irritation and cancer from Arsenic is often easily cured when detected early. burns leading to permanent damage. * Breathing Ethyl Dichloroarsine can irritate the nose and If symptoms develop or overexposure is suspected, the throat. following is recommended: * Breathing Ethyl Dichloroarsine can irritate the lungs causing coughing and/or shortness of breath. Higher * Consider chest x-ray after acute overexposure. exposures can cause a build-up of fluid in the lungs (pulmonary edema), a medical emergency, with severe Any evaluation should include a careful history of past and shortness of breath. present symptoms with an exam. Medical tests that look for * High exposure can cause poor appetite, a metallic or garlic damage already done are not a substitute for controlling taste, nausea, vomiting and stomach cramps. exposure.

Chronic Health Effects Request copies of your medical testing. You have a legal The following chronic (long-term) health effects can occur at right to this information under OSHA 1910.1020. some time after exposure to Ethyl Dichloroarsine and can last for months or years: Mixed Exposures * Because smoking can cause heart disease, as well as lung Cancer Hazard cancer, emphysema, and other respiratory problems, it may * According to the information presently available to the worsen respiratory conditions caused by chemical New Jersey Department of Health and Senior Services, exposure. Even if you have smoked for a long time, Ethyl Dichloroarsine has not been tested for its ability to stopping now will reduce your risk of developing health cause cancer in animals. problems.

Reproductive Hazard Conditions Made Worse by Exposure * According to the information presently available to the * Many scientists believe that skin changes such as New Jersey Department of Health and Senior Services, thickening and pigment changes make those skin areas Ethyl Dichloroarsine has not been tested for its ability to more likely to develop skin cancer. affect reproduction. WORKPLACE CONTROLS AND PRACTICES Other Long-Term Effects * Repeated skin contact can cause thickening and color Unless a less toxic chemical can be substituted for a hazardous changes (patchy areas of darkening and loss of pigment). substance, ENGINEERING CONTROLS are the most * Long term exposure can cause an ulcer or hole in the effective way of reducing exposure. The best protection is to “bone” dividing the inner nose. enclose operations and/or provide local exhaust ventilation at * Ethyl Dichloroarsine can irritate the lungs. Repeated the site of chemical release. Isolating operations can also exposure may cause bronchitis to develop with cough, reduce exposure. Using respirators or protective equipment is phlegm, and/or shortness of breath. less effective than the controls mentioned above, but is * High or repeated exposure may damage the nerves causing sometimes necessary. weakness, "pins and needles," and poor coordination in arms and legs.

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In evaluating the controls present in your workplace, consider: Clothing (1) how hazardous the substance is, (2) how much of the * Avoid skin contact with Ethyl Dichloroarsine. Wear substance is released into the workplace and (3) whether protective gloves and clothing. Safety equipment harmful skin or eye contact could occur. Special controls suppliers/manufacturers can provide recommendations on should be in place for highly toxic chemicals or when the most protective glove/clothing material for your significant skin, eye, or breathing exposures are possible. operation. * All protective clothing (suits, gloves, footwear, headgear) In addition, the following control is recommended: should be clean, available each day, and put on before work. * Where possible, automatically pump liquid Ethyl Dichloroarsine from drums or other storage containers to process containers. Eye Protection * Wear indirect-vent, impact and splash resistant goggles Good WORK PRACTICES can help to reduce hazardous when working with liquids. exposures. The following work practices are recommended: * Wear a face shield along with goggles when working with corrosive, highly irritating or toxic substances. * Workers whose clothing has been contaminated by Ethyl Dichloroarsine should change into clean clothing Respiratory Protection promptly. IMPROPER USE OF RESPIRATORS IS DANGEROUS. * Contaminated work clothes should be laundered by Such equipment should only be used if the employer has a individuals who have been informed of the hazards of written program that takes into account workplace conditions, exposure to Ethyl Dichloroarsine. requirements for worker training, respirator fit testing and * Eye wash fountains should be provided in the immediate medical exams, as described in OSHA 1910.134. work area for emergency use. * If there is the possibility of skin exposure, emergency * Where the potential for exposure exists, use a shower facilities should be provided. MSHA/NIOSH approved supplied-air respirator with a full * On skin contact with Ethyl Dichloroarsine, immediately facepiece operated in a pressure-demand or other positive- wash or shower to remove the chemical. At the end of the pressure mode. For increased protection use in workshift, wash any areas of the body that may have combination with an auxiliary self-contained breathing contacted Ethyl Dichloroarsine, whether or not known apparatus operated in a pressure-demand or other positive- skin contact has occurred. pressure mode. * Do not eat, smoke, or drink where Ethyl Dichloroarsine * Exposure to 3 ppm (as Arsine) is immediately dangerous is handled, processed, or stored, since the chemical can be to life and health. If the possibility of exposure above swallowed. Wash hands carefully before eating, drinking, 3 ppm (as Arsine) exists, use a MSHA/NIOSH approved smoking, or using the toilet. self-contained breathing apparatus with a full facepiece operated in a pressure-demand or other positive-pressure PERSONAL PROTECTIVE EQUIPMENT mode.

WORKPLACE CONTROLS ARE BETTER THAN QUESTIONS AND ANSWERS PERSONAL PROTECTIVE EQUIPMENT. However, for some jobs (such as outside work, confined space entry, jobs Q: If I have acute health effects, will I later get chronic done only once in a while, or jobs done while workplace health effects? controls are being installed), personal protective equipment A: Not always. Most chronic (long-term) effects result may be appropriate. from repeated exposures to a chemical.

OSHA 1910.132 requires employers to determine the Q: Can I get long-term effects without ever having short- appropriate personal protective equipment for each hazard and term effects? to train employees on how and when to use protective A: Yes, because long-term effects can occur from repeated equipment. exposures to a chemical at levels not high enough to make you immediately sick. The following recommendations are only guidelines and may not apply to every situation. Q: What are my chances of getting sick when I have been exposed to chemicals? A: The likelihood of becoming sick from chemicals is increased as the amount of exposure increases. This is determined by the length of time and the amount of material to which someone is exposed. ETHYL DICHLOROARSINE page 4 of 6

Q: When are higher exposures more likely? ------A: Conditions which increase risk of exposure include The following information is available from: physical and mechanical processes (heating, pouring, spraying, spills and evaporation from large surface areas New Jersey Department of Health and Senior Services such as open containers), and "confined space" Occupational Health Service exposures (working inside vats, reactors, boilers, small PO Box 360 rooms, etc.). Trenton, NJ 08625-0360 (609) 984-1863 Q: Is the risk of getting sick higher for workers than for (609) 292-5677 (fax) community residents? A: Yes. Exposures in the community, except possibly in Web address: http://www.state.nj.us/health/eoh/odisweb/ cases of fires or spills, are usually much lower than those found in the workplace. However, people in the Industrial Hygiene Information community may be exposed to contaminated water as Industrial hygienists are available to answer your questions well as to chemicals in the air over long periods. This regarding the control of chemical exposures using exhaust may be a problem for children or people who are already ventilation, special work practices, good housekeeping, good ill. hygiene practices, and personal protective equipment including respirators. In addition, they can help to interpret the results of industrial hygiene survey data.

Medical Evaluation If you think you are becoming sick because of exposure to chemicals at your workplace, you may call personnel at the Department of Health and Senior Services, Occupational Health Service, who can help you find the information you need.

Public Presentations Presentations and educational programs on occupational health or the Right to Know Act can be organized for labor unions, trade associations and other groups.

Right to Know Information Resources The Right to Know Infoline (609) 984-2202 can answer questions about the identity and potential health effects of chemicals, list of educational materials in occupational health, references used to prepare the Fact Sheets, preparation of the Right to Know survey, education and training programs, labeling requirements, and general information regarding the Right to Know Act. Violations of the law should be reported to (609) 984-2202. ------ETHYL DICHLOROARSINE page 5 of 6

DEFINITIONS

ACGIH is the American Conference of Governmental A mutagen is a substance that causes mutations. A mutation Industrial Hygienists. It recommends upper limits (called is a change in the genetic material in a body cell. Mutations TLVs) for exposure to workplace chemicals. can lead to birth defects, miscarriages, or cancer.

A carcinogen is a substance that causes cancer. NAERG is the North American Emergency Response Guidebook. It was jointly developed by Transport Canada, The CAS number is assigned by the Chemical Abstracts the United States Department of Transportation and the Service to identify a specific chemical. Secretariat of Communications and Transportation of Mexico. It is a guide for first responders to quickly identify the specific A combustible substance is a solid, liquid or gas that will or generic hazards of material involved in a transportation burn. incident, and to protect themselves and the general public during the initial response phase of the incident. A corrosive substance is a gas, liquid or solid that causes irreversible damage to human tissue or containers. NCI is the National Cancer Institute, a federal agency that determines the cancer-causing potential of chemicals. DEP is the New Jersey Department of Environmental Protection. NFPA is the National Fire Protection Association. It classifies substances according to their fire and explosion DOT is the Department of Transportation, the federal agency hazard. that regulates the transportation of chemicals. NIOSH is the National Institute for Occupational Safety and EPA is the Environmental Protection Agency, the federal Health. It tests equipment, evaluates and approves respirators, agency responsible for regulating environmental hazards. conducts studies of workplace hazards, and proposes standards to OSHA. A fetus is an unborn human or animal. NTP is the National Toxicology Program which tests A flammable substance is a solid, liquid, vapor or gas that chemicals and reviews evidence for cancer. will ignite easily and burn rapidly. OSHA is the Occupational Safety and Health Administration, The flash point is the temperature at which a liquid or solid which adopts and enforces health and safety standards. gives off vapor that can form a flammable mixture with air. PEOSHA is the Public Employees Occupational Safety and HHAG is the Human Health Assessment Group of the federal Health Act, a state law which sets PELs for New Jersey public EPA. employees.

IARC is the International Agency for Research on Cancer, a ppm means parts of a substance per million parts of air. It is a scientific group that classifies chemicals according to their measure of concentration by volume in air. cancer-causing potential. A reactive substance is a solid, liquid or gas that releases A miscible substance is a liquid or gas that will evenly energy under certain conditions. dissolve in another. A teratogen is a substance that causes birth defects by mg/m3 means milligrams of a chemical in a cubic meter of damaging the fetus. air. It is a measure of concentration (weight/volume). TLV is the Threshold Limit Value, the workplace exposure MSHA is the Mine Safety and Health Administration, the limit recommended by ACGIH. federal agency that regulates mining. It also evaluates and approves respirators. The vapor pressure is a measure of how readily a liquid or a solid mixes with air at its surface. A higher vapor pressure indicates a higher concentration of the substance in air and therefore increases the likelihood of breathing it in.

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Common Name: ETHYL DICHLOROARSINE HANDLING AND STORAGE DOT Number: UN 1892 NAERG Code: 151 * Prior to working with Ethyl Dichloroarsine you should be CAS Number: 598-14-1 trained on its proper handling and storage. * Ethyl Dichloroarsine must be stored to avoid contact with OXIDIZING AGENTS (such as PERCHLORATES, Hazard rating NJDHSS NFPA PEROXIDES, PERMANGANATES, CHLORATES, FLAMMABILITY - - NITRATES, CHLORINE, BROMINE and FLUORINE). * Ethyl Dichloroarsine will react with STRONG ACIDS REACTIVITY 1 - (such as HYDROCHLORIC, SULFURIC and NITRIC) and POISONOUS GASES ARE PRODUCED IN FIRE ACID MISTS to produce deadly Arsine gas. CONTAINERS MAY EXPLODE IN FIRE * Store in tightly closed containers in a cool, well-ventilated DO NOT USE WATER area.

Hazard Rating Key: 0=minimal; 1=slight; 2=moderate; 3=serious; 4=severe FIRST AID

In NJ, for POISON INFORMATION call 1-800-764-7661 FIRE HAZARDS

* Use dry chemical, CO2, or foam extinguishers. * POISONOUS GASES ARE PRODUCED IN FIRE, Eye Contact including Chlorine, Arsine and Phosgene. * Immediately flush with large amounts of water for at least * CONTAINERS MAY EXPLODE IN FIRE. 15 minutes, occasionally lifting upper and lower lids. * Use water spray to keep fire-exposed containers cool. * DO NOT USE WATER as Ethyl Dichloroarsine Skin Contact decomposes in water and releases Chlorine gas. * Remove contaminated clothing. Wash contaminated skin * If employees are expected to fight fires, they must be trained with soap and water. and equipped as stated in OSHA 1910.156. Breathing SPILLS AND EMERGENCIES * Remove the person from exposure. * Begin rescue breathing (using universal precautions) if If Ethyl Dichloroarsine is spilled or leaked, take the following breathing has stopped and CPR if heart action has stopped. steps: * Transfer promptly to a medical facility. * Medical observation is recommended for 24 to 48 hours * Evacuate persons not wearing protective equipment from after breathing overexposure, as pulmonary edema may be area of spill or leak until clean-up is complete. delayed. * Absorb liquids in vermiculite, dry sand, earth, or a similar material and deposit in sealed containers. PHYSICAL DATA * Ventilate and wash area after clean-up is complete. * DO NOT USE WATER OR WET METHOD. Vapor Pressure: 2.29 mm Hg at 70oF (21.5oC) * It may be necessary to contain and dispose of Ethyl Dichloroarsine as a HAZARDOUS WASTE. Contact your Water Solubility: Decomposes Department of Environmental Protection (DEP) or your regional office of the federal Environmental Protection OTHER COMMONLY USED NAMES Agency (EPA) for specific recommendations. * If employees are required to clean-up spills, they must be Chemical Name: properly trained and equipped. OSHA 1910.120(q) may be Arsonous Dichloride, Ethyl- applicable. Other Names: Dichloroethylarsine; Arsenic Dichloroethane ======FOR LARGE SPILLS AND FIRES immediately call your fire ------department. You can request emergency information from the Not intended to be copied and sold for commercial following: purposes. CHEMTREC: (800) 424-9300 ------NJDEP HOTLINE: (609) 292-7172 NEW JERSEY DEPARTMENT OF HEALTH AND ======SENIOR SERVICES Right to Know Program PO Box 368, Trenton, NJ 08625-0368 (609) 984-2202 ------