VOLUME 19 • NUMBER 1 • 2017 FOR ALUMNI, FRIENDS, FACULTY AND STUDENTS OF THE UNIVERSITY OF WISCONSIN SCHOOL OF MEDICINE AND PUBLIC HEALTH Quarterly

SPORE Grant BOLSTERS CANCER TREATMENT RESEARCH

HISTORIC COLLECTION p. 8 INTERPROFESSIONAL HEALTH EDUCATION p. 12

ALUMNI WINTER EVENT p. 16

There’s More Online! Visit med.wisc.edu/quarterly to be

QUARTERLY The Magazine for Alumni, Friends, APRIL 2017 Faculty and Students of the University of Wisconsin School of Medicine and Public Health Friday, April 21 Spring WMAA Board Meeting, SMPH/WMAA Scholarship Reception and MANAGING EDITOR WMAA Awards Banquet Kris Whitman ART DIRECTOR Christine Klann PRINCIPAL PHOTOGRAPHER MAY 2017 John Maniaci Thursday, May 11 SMPH Honors and Awards Ceremony PRODUCTION Michael Lemberger Friday, May 12 UW-Madison Commencement

WISCONSIN MEDICAL ALUMNI ASSOCIATION (WMAA) EXECUTIVE DIRECTOR JUNE 2017 Karen S. Peterson Thursday and Friday, Spring Alumni Weekend EDITORIAL BOARD June 1 and 2 Class Reunions for Classes of ’52, ’57, ’62, ’67 Christopher L. Larson, MD ’75, chair and the Half-Century Society (all alumni who Jacquelynn Arbuckle, MD ’95 graduated before 1967) Kathryn S. Budzak, MD ’69 Robert Lemanske, Jr., MD ’75 Patrick McBride, MD ’80, MPH

Gwen McIntosh, MD ’96, MPH CALENDAR Sandra L. Osborn, MD ’70 SEPTEMBER 2017 Patrick Remington, MD ’81, MPH Friday, September 15 Middleton Society Dinner Joslyn Strebe, medical student

EX OFFICIO MEMBERS Robert N. Golden, MD, Andrea Larson, Karen S. Peterson, Jill Watson, Kris Whitman OCTOBER 2017 Friday and Saturday, Fall WMAA Board Meeting BOARD OF DIRECTORS 2016–2017 October 20 and 21 Homecoming Weekend, UW vs. Maryland (Note updated dates) Class Reunions for Classes of ’72, ’77, ’82, ’87, OFFICERS Susan Isensee, MD ’83, president ’92, ’97, ’02, ’07, ’12 Daniel Jackson, MD ’03, president-elect Ann Ruscher, MD ’91, treasurer Patrick McBride, MD ’80, MPH, past president Steve Merkow, MD ’80, past president BOARD MEMBERS Karen Adler-Fischer, MD ’80 Mathew Aschbrenner, MD ’06 Mark Fenlon, MD ’84, MBA Dirk Fisher, MD ’79 Jennifer Foster, MD ’04 John Kryger, MD ’92 Christopher L. Larson, MD ’75 Kyla Lee, MD ’98 Meghan Lubner, MD ’03 Gwen McIntosh, MD ’96 Kathryn E. Nixdorf, MD ’06 (national) Leon E. Rosenberg, MD ’57 (national) John Siebert, MD ’81 Alex Tucker, MD ’75 Steven Wiesner, MD ’85 (national) Michael Witcik, MD ’07 BOARD ADVISORY COUNCIL Kathryn S. Budzak, MD ’69 Philip Farrell, MD, PhD Donn Fuhrmann, MD ’76 Kay Gruling, MD ’88 QUARTERLY is published four times a year by the Wisconsin Medical Alumni Association (WMAA) Charles V. Ihle, MD ’65 and the University of Wisconsin School of Medicine and Public Health (SMPH) Thomas Jackson, MD ’67 For editorial information, call (608) 263-4613 Ann Liebeskind, MD ’98 For address corrections and to reach the WMAA, call (608) 263-4915 Sandra L. Osborn, MD ’70 Anne Schierl, MD ’57 E-mail us at [email protected] Visit us on the web at med.wisc.edu/quarterly CONTENTS QUARTERLY • VOLUME 19 • NUMBER 1

SPORE GRANT HISTORIC 16 Alumni Notebook This competitive federal COLLECTION 4 funding is allowing several 8 23 Goodbye Dear Friends Donated letters and multidisciplinary teams autographs by historical 25 Student Life to pursue research into figures help preserve stories cancer treatments that will from yesteryear. 26 Alumni Profile benefit patients who have head and neck cancer. 28 Spotlight 30 Healer’s Journey INTER- Campus Scene (above) 32 Connections PROFESSIONAL A French bulldog stands watch as its owners take a 34 Leader Q&A 12 HEALTH study break at UW-Madison in mid-February. That day’s temperatures were unseasonably warm, but EDUCATION winter weather soon returned to the region. 36 Research Advances A new center fosters Photo by Jeff Miller/UW-Madison a teamwork approach 40 Perspectives to training. On the Cover Chunrong Li, PhD (left), and Lauryn Werner— researchers with the Specialized Programs of Research Excellence project—collect incubated cell cultures.

QUARTERLY 1 MESSAGES

ROBERT N. GOLDEN, MD transparent and collaborative relationships to advance potential new treatments from the bench to the bedside. We are delighted that our new medical students also are “hanging together,” as they create their class’s unique code of honor. More importantly, they are working together to insure, individually and collectively, that they fulfill the aspirational goals contained within their code of honor. Over the course of their careers, we hope many of our students will follow in the footsteps of Dr. John Drawbert, a distinguished alumnus who co-founded a “best in class,” community-based surgical hospital that brings together patients and the entire health care team in the true spirit of patient-centered care and patient- provider partnerships. As we go to press, we are entering the annual period of “March Madness.” We are n the eve of the American Revolution, Research Excellence (SPORE) grant from inspired by the success of the Badger men’s one of our founding fathers urged, the National Cancer Institute. This grant will basketball team as they “hang together” O“We must, indeed, all hang together, support the creation of new innovations and and rise in the national rankings. I hope or assuredly we shall all hang separately.” synergies in our ongoing battle against this this shout-out inspires the team, as we During these revolutionary times in American devastating group of illnesses. look forward to the drama and excitement health care, academic medicine—and On page 34, our Q&A section features of the NCAA tournament. We also are public higher education, in general—must Dr. Brian Gittens, who is playing an important looking forward to the joys of spring at the “hang together” and form meaningful leadership role in the creation of the best SMPH—including Match Day, graduation partnerships if we are to successfully possible climate and environment for and the return of majestic Sandhill Cranes advance our missions. To that end, we attracting and retaining an increasingly to the marsh near the Health Sciences summarize on pages 12 through 15 the diverse community of learners, teachers, Learning Center. progress of our comprehensive spectrum faculty and staff. These efforts will increase of health professions training programs our school’s opportunity to bring together Robert N. Golden, MD as they “hang together” in advancing people with different backgrounds, Dean, University of Wisconsin School of interprofessional health education. This perspectives and experiences, with an eye Medicine and Public Health is important as we anticipate health care toward establishing an inclusive and collegial Vice Chancellor for Medical Affairs, delivery becoming more and more of a environment where everyone can attain their UW-Madison “team sport.” full potential. We also celebrate the successful The University of Wisconsin School “hanging together” of a diverse team of Medicine and Public Health (SMPH), of scientists who share the common UW Carbone Cancer Center and goal of improving our understanding of UW Health are ramping up our efforts to head and neck cancers and developing “hang together” with the private sector and new treatments. Led by Dr. Paul Harari, relevant industries. Under the outstanding this multidisciplinary group successfully leadership of Dr. Rick Moss, we have competed for a Specialized Programs of created a groundbreaking model for ethical,

2 VOLUME 19 • NUMBER 1 KAREN S. PETERSON reetings medical alumni and friends! In addition to those four classes, we Your Wisconsin Medical Alumni welcome all alumni who graduated before GAssociation (WMAA) has had another 1967 to join the festivities. We proudly call busy season coordinating engaging events these alumni members of our Half-Century for alumni, faculty and students of the Society. Rather than wait to gather every five University of Wisconsin School of Medicine years, we hope anyone who graduated 50 and Public Health (SMPH). or more years ago will accept our invitation We recently hosted the annual Operation to attend the spring reunions as often as they Education. Central to our mission to foster can make it to Madison. We’d love to have meaningful connections between medical you come every year! students and our school’s graduates, On that weekend, all alumni are invited faculty members and house staff, nearly to attend a Mini Med School session, titled, 140 students and 65 alumni, faculty and “Would You Like to Talk about What that residents attended the January 2017 event. Means? Communicating with Your Doctor We had more specialties and subspecialties for Better Health,” on Thursday, June 1, represented than any past Operation 2017, from 6:30-8:00 pm in Alumni Hall, Education event, and many alumni attended room 1306 Health Sciences Learning Center for the first time. That evening, physicians (HSLC), with a reception to follow in the HSLC shared their knowledge and advice about atrium. The session will be led by Dr. Toby various medical specialties with students, Campbell, a member of the UW Carbone who strive to learn from those who are Cancer Center. He’ll be joined by a panel of farther along that journey. We are very presenters from various SMPH departments. grateful for everyone who donated their time Spring in Madison is a delightful time to talk with students, and we hope you’ll for all of the Alumni Weekend events, consider doing so in the future. including a trolley tour of campus, a tour of The recent Winter Event, covered on the anatomy lab in the Medical Sciences pages 16 and 17, was equally successful. Center, Dean Robert Golden’s reception and Held on Friday, February 24, 2017, at the class dinners. Participants also will have Fluno Center on campus, this annual event opportunities to meet with student leaders, provided another opportunity for alumni to as well as the recipients of scholarships connect with each other, hear about exciting and stethoscopes. happenings at the school and meet with We’re grateful for all that our alumni have students. We enjoyed the chance to introduce done to support the SMPH. So many of you stethoscope donors with their student have been incredibly generous with your recipients. Again, students were eager to time, talent and treasure. We hope you can share their gratitude with donors and learn take time to visit your alma mater! about the careers of alumni. Thank you to all Please feel free to contact me with any who came and shared their time. questions or ideas. You can reach me by We are now looking forward to the season e-mail at [email protected] or telephone at of spring alumni reunions. Representatives (608) 263-4913. If you prefer to correspond for the Classes of 1952, ’57, ’62 and ’67 are by mail, you’ll find my address on the back busy working with the WMAA staff to plan cover of this issue. their class reunions, which will be held in I look forward to hearing from you! conjunction with Alumni Weekend, Thursday and Friday, June 1 and 2, 2017. See pages Karen S. Peterson 18 and 19 for updates from some class Executive Director, Wisconsin representatives. Medical Alumni Association

QUARTERLY 3 FEATURE STORY

Paul Harari, MD, is the principal investigator of the UW-Madison SPORE grant, which includes multiple research projects and teams.

4 VOLUME 19 • NUMBER 1 BY SUSAN LAMPERT SMITH

SPORE Grant FEDERAL FUNDING BOLSTERS CANCER TREATMENT RESEARCH

n recent years, a light often burned late in that year. The federal SPORE Program funds a Department of Human Oncology office all or nothing, and only about 10 percent of Iat the University of Wisconsin School of proposals are accepted. Medicine and Public Health (SMPH). There, “It was painful to come so close and wind you’d find Department Chair Paul Harari, MD, up with nothing,’’ says Harari, who by that toiling over a project that resembled point kept slippers in his office because he Sisyphus’s mythical task: rolling a boulder up spent so many evenings there. a hill, only to have it come crashing down. But the Wisconsin team kept pushing Harari’s “boulder” was the UW Carbone toward the end goal. Cancer Center’s (UWCCC) application to earn Gregory Hartig, MD, who shares Harari’s its first Specialized Programs of Research passion, remembers the struggle. Excellence (SPORE) grant from the National “I would come to the hospital to round on Paul Harari, MD (left), and patient Marshall Flax, a head Cancer Institute (NCI). Although the UWCCC my patients on beautiful, sunny Saturdays, and neck cancer survivor, who has given back consistently was among the nation’s first federally and Paul would be in his office for 12 hours,’’ to the UW-Madison head and neck cancer program since recognized cancer centers, it took many recalls Hartig, a member of the SPORE his cancer diagnosis and successful treatment in 2003. years to earn this top research award. team and chief of the Section of Head and In fact, four times since convening the Neck Surgical Oncology in the Division of UW-Madison SPORE effort in 2010, Harari’s Otolaryngology–Head and Neck Surgery. team submitted a massive proposal to the “I was inspired by Paul’s dedication— NCI for a grant in head and neck cancer he simply did not give up.” (HNC) research. About 40 faculty members The effort finally paid off in 2016. contributed to the proposal, with the goal Following an NCI review, the UW-Madison of moving cutting-edge research from the $14 SPORE application earned an exceptionally laboratory into the clinical setting where it high score, thereby winning $11 million in could directly benefit patients. Although the Million research funding, with an additional 2013 SPORE proposal ranked very highly Total funding support for $3 million in UW-Madison matching funds. in the nation, it just missed the NCI payline major research projects This funding supports four primary research and clinical trials to QUARTERLY benefit cancer patients 5 700 calories daily via a nasal-gastric tube, he lost 45 pounds and battled pain, fatigue and dehydration. The treatment also affected his salivary glands, and he has never fully regained his ability to taste sweet flavors. Because Flax survived with his physical appearance intact, Harari describes him as “one of the patients who wear his scars invisibly.” Still, Flax knows his radiotherapy was a major improvement compared to treatment that was available earlier. “I had it so much better than the people who came before me,’’ says Flax, an active Left to right: Deric Wheeler, PhD ’04, Paul Harari, MD, Randall Kimple, MD, PhD, Greg Hartig, MD. member of the head and neck cancer survivor group at UW Health, where he has raised awareness about HNC, provided projects (see page 7) and several innovative damage of HNC radiation treatments. support, participated in fundraising efforts clinical trials to benefit HNC patients. For instance, T. Rockwell Mackie, PhD, and encouraged patients to participate in The SPORE grant also includes pilot emeritus professor of medical physics and clinical trials. project money to help the SMPH grow its human oncology, and his colleagues were “The people who took care of me are the next generation of researchers, as well as developing a new technology to deliver only reason I’m alive, and I feel personally support for established researchers who are intensity-modulated radiation therapy (IMRT), obligated to give back,’’ he says. interested in applying their expertise to new which allows radiation oncologists to sculpt Like other grateful patients, Flax wrote projects in head and neck cancer. the beam more precisely to the tumor. letters of support each time Harari’s group “These dollars will be spent on research Mackie’s work led to the founding in Madison submitted SPORE grant applications to here at UW-Madison, so it’s a wonderful of TomoTherapy, which was purchased by the NCI. opportunity for young scientists to start Accuray in 2011. “I’m a big believer in research, and new projects in the field,” exclaims Hartig. “Before the development of IMRT, we had even though the gains may seem like small “That’s one of the most exciting parts of the to shine radiation beams directly through steps, they add up to big improvements for SPORE grant.” nearby normal organs,’’ Harari recalls. “IMRT patients,” he shares. Noting that head and neck cancer is a enabled us to tailor the dose to the tumor Flax hopes the grant helps Harari and his particularly cruel disease, Harari and Hartig and reduce the damage to normal tissue.” team discover better measures to prevent say their patients provided their motivation to Harari hoped that one of his patients, HNC and better treatments that reduce the keep applying for SPORE funding. Few other Marshall Flax, would be a candidate “collateral damage” for patients. types of cancer survivors wear their suffering for IMRT—which had been in use at Incremental research advances enabled so visibly. UW Hospital and Clinics for only a few years Harari and colleagues to conduct an “Many head and neck cancer patients when Flax’s advanced tonsil cancer was international clinical trial, published in 2006 wear their battle scars in public—they can discovered by fluke in 2003. Then 50 years in the New England Journal of Medicine, lose their ability to speak, taste and swallow old, Flax went in for a tonsillectomy to reduce that confirmed the ability of a new molecular naturally,’’ says Harari. “We owe them a his snoring, but his surgeon discovered cancer drug—cetuximab—combined with better future. While we are able to offer cancer of the tonsil. Next, Harari diagnosed radiation to improve survival rates for HNC cutting-edge care in head and neck cancer Flax as having stage 4 cancer that had patients. The UW-Madison team hopes to treatment here at UW Health, it’s simply already spread to lymph nodes in his neck. make other major research advances through not good enough. There are still too many Deemed not an ideal candidate for the SPORE grant to help future patients. recurrences, too many side effects, and too IMRT because he had multiple tumors in Harari expressed deep gratitude to many deaths.” both sides of his upper neck, Flax endured his surgical colleagues on the SPORE When Harari, now the Jack Fowler difficult radiation and chemotherapy grant— notably Hartig and Tim McCulloch, Professor of Human Oncology, joined the treatments. Radiation left him with what he MD, professor of surgery and head of the SMPH faculty in 1990, researchers at describes as “the world’s worst sunburn” Division of Otolaryngology–Head and Neck UW-Madison and elsewhere were making in his throat, limiting his ability to swallow Surgery, who co-lead SPORE projects and great strides in reducing the collateral for several months. Struggling to consume —Continued on page 39

6 VOLUME 19 • NUMBER 1 Major Projects Supported by the SPORE Grant

Wisconsin’s first-ever Specialized to HNC. They plan to identify new targets has developed peptides (synstatins) that Programs of Research Excellence (SPORE) for therapy and biomarkers that better interrupt syndecans and thereby slow grant features four major scientific predict outcomes for cancer patients. tumor growth. The team will be testing projects designed to bring research from Cancer-Seeking Molecule these peptides in mice, and if successful, the lab into clinical trials to create better Harari and Greg Hartig, MD, professor, they hope human clinical trials will follow. treatments for patients who have head and Department of Surgery, will use the The AXL Receptor neck cancer (HNC). “Wisconsin molecule” developed by Deric Wheeler, PhD ’04, associate Underlying and supporting the work of Jamey Weichert, PhD, associate professor, professor, Department of Human Oncology, all four projects are the Statistical Core, Department of Radiology, and colleagues, has shown that a cellular receptor called led by Menggang Yu, PhD, professor, in a clinical trial. Known as CLR1404, the AXL may play a significant role in why Department of Biostatistics and Medical molecule is selectively taken up by cancer HNC cells become resistant to the drug Informatics, and the Pathology Core, led by cells and can carry with it a payload of cetuximab. He will examine whether David Yang, MD, associate professor, and targeted radiation. The work begins in inhibiting AXL in mice will make HNC Ricardo Lloyd, MD ’75, PhD ’75, professor, mice with HNC tumors. The scientists tumors more sensitive to the drug. Wheeler Department of Pathology and Laboratory have designed a Phase 1 clinical trial for and project co-leader Randall Kimple, MD, Medicine, University of Wisconsin School of HNC patients in hopes that the targeted PhD, assistant professor, Department of Medicine and Public Health (SMPH). molecule will allow them to reduce the Human Oncology, will direct a clinical trial “The work of the Pathology and dose of external beam radiation and in patients with cetuximab-resistant HNC. Statistical Cores is critical to the SPORE thereby save more healthy tissue. Future Projects grant’s success,” says Paul Harari, MD, Synstatins The SPORE grant will solicit pilot chair of the SMPH Department of Human Alan Rapraeger, PhD, professor, HNC research proposals, with the goal Oncology and principal investigator of the Department of Human Oncology, and of funding promising new projects by SPORE grant at the UW Carbone Cancer Justine Bruce, MD, assistant professor, junior faculty and new research by Center (UWCCC). “Wisconsin is known for Department of Medicine, will seek to inhibit established scientists. the depth of its basic science research, and receptors called syndecans. These complex “We want to help UW-Madison cancer these projects—which pair basic science receptors are found in the membranes of researchers join in our collective pursuit research with clinicians—will bring that HNC cells, where they organize groups of more effective treatments for HNC research from the lab to our patients.” of receptors into signaling hubs that patients,’’ Harari says. The four major SPORE projects and promote cancer cell growth. Rapraeger their basic and clinical science research leaders are: Cancer Pathways Paul Lambert, PhD, the Howard Temin Chair of Oncology and director, McArdle Laboratory for Cancer Research, will lead this project, along with surgeon Timothy McCulloch, MD, head, Division of Otolaryngology-Head and Neck Surgery, Department of Surgery. Lambert—an international expert in the study of the human papillomavirus, which causes certain HNC cancers—created transgenic mouse models that enable better understanding of mutations that contribute Left to right: Chunrong Li, PhD, and Lauryn Werner, listen as Paul Lambert, PhD, describes settings on an experimental irradiator at the Wisconsin Institutes for Medical Research.

QUARTERLY 7 PHOTO FEATURE Letters from Luminaries HISTORIC COLLECTION SPEAKS VOLUMES

he University of Wisconsin School of Medicine and Public Health (SMPH) is known for its Tworld-class research and teaching, as well as a superb medical library, but it also is home to a lesser known—but perhaps equally prestigious—collection of historical autographs and letters. Located in the Health Sciences Learning Center, this collection includes pieces written by some of the most influential people in medical history, including Marie Curie, Louis Pasteur, PhD, Albert Sabin, MD, and Robert Koch, MD, and American political figures “Fighting Bob” La Follette and Abraham Lincoln. Michael Kappy, MD ’67, PhD ’67, professor of pediatrics and endocrinology, University of Colorado School of Medicine, donated most of the letters and autographs to the SMPH around 2007. The remaining pieces—a signed letter from Lincoln Name: Abraham Lincoln and an 1862 Harper’s Weekly illustration of battlefield Circa: 1863 surgeons in the Civil War—were donated by Daniel Donated by: Daniel Albert, MD, MS ’97, and Eleanor Albert Albert, MD, MS ’97, and his wife, Eleanor Albert. In total, the collection contains about 12 historical A personal letter from Lincoln to Thomas J. Pickett of Rock Island, Illinois. Pickett, a letters and autographs, and represents a broad range newspaper editor in Rock Island, was an old friend of Lincoln who, in 1859, wrote of thoughts by the authors. For example, Sir Alexander a letter to Lincoln asking him to consider a race for the presidency. After Lincoln eventually won the office, he appointed Pickett an agent in the Quartermaster’s Fleming, MBBS, penned a letter thanking someone Department for the Island of Rock Island, according to letters at the Library of for returning a passport, while another piece from Congress. On April 3, 1863, Pickett sent Lincoln a telegraph informing him that La Follette is a summons to a man in Montana to appear he had been removed from office over charges he sold government-owned timber before a U.S. Senate committee. and stone for personal gain. On April 20—just two days after Lincoln wrote this “Each day, I feel privileged and honored to walk letter—Lincoln reinstated Pickett. past the letters and photographs of these remarkable individuals who shaped the destiny of our field, our Notable contributions: Lincoln was the 16th president of the United States, state and our nation,” says Robert Golden, MD, dean of elected in 1861 and re-elected in 1864. During this time, he led the country the SMPH. “These historic documents inspire all of us through the Civil War, brought national prominence to the Republican Party and on to appreciate the impact we can have, individually and January 1, 1863, issued the Emancipation Proclamation that gave freedom to slaves collectively, on the lives of the people whom we serve.” in the Confederacy, according to the Library of Congress. On April 14, 1865, he was assassinated at Ford’s Theatre in Washington, DC, by John Wilkes Booth.

8 VOLUME 19 • NUMBER 1 BY ANDREW HELLPAP

Name: Robert Koch, MD Circa: 1883 Donated by: Michael Kappy, MD ’67, PhD ’67

A personal letter from Koch, while he was in Egypt serving as the leader of the German Cholera Commission, according to the Nobel Prize web site. Koch was likely staying at the Hotel du Nile, as noted in the letter. He was sent to Egypt to investigate an outbreak of cholera. Name: Louis Pasteur, PhD There he discovered the vibrio that causes cholera and brought the Circa: 1887 cultures back to Germany. Donated by: Michael Kappy, MD ’67, PhD ’67

Notable contributions: It is fitting that Koch and Louis Pasteur are A note from Pasteur (recipient unknown). The note was written together in this collection. History remembers them as scientific rivals, shortly before the November 1888 opening of the Institut Pasteur, and they were certainly contemporaries studying infectious diseases. a premier biomedical research center built for Pasteur; it is still in operation today. Also, in 1887, Pasteur was appointed perpetual In addition to his work with cholera, Koch was awarded the Nobel secretary of the Academy of Sciences. Prize for his investigations and discoveries related to tuberculosis. This included the discovery of tuberculosis bacterium in 1882, according Notable contributions: People and many commercial industries to the Nobel Prize web site. Like Pasteur, he made many significant throughout the world have Pasteur to thank for his scientific contributions to science and medicine. Koch confirmed that anthrax research. His invention of the pasteurization process allowed for disease was caused by anthrax bacteria, and that it could be spread better preservation for beer and dairy products. This process by the blood of animals infected with the disease. He also showed involves heating a liquid to a temperature that kills organisms the bacteria could go dormant and return when conditions became that otherwise would break down the liquid. But this is far from favorable, and that they cause the disease without having ever Pasteur’s only significant contribution to science and medicine. touched an animal. In fact, he is considered a pioneer in immunology. He developed a vaccine for anthrax, and later the first vaccine against rabies.

QUARTERLY 9 Name: Sir William Osler, MDCM Circa: 1906 Donated by: Michael Kappy, MD ’67, PhD ’67 Name: Robert M. La Follette, Sr. (Fighting Bob) Circa: 1920 A personal letter from Osler to Marcia Noyes, the first full-time Donated by: Michael Kappy, MD ’67, PhD ’67 librarian at the Medical and Chirurgical Faculty Library in Baltimore. Osler recommended she be hired at the library, according to a A summons made by La Follette in 1923 to Joseph Russell of the 1974 article, titled “Marcia Crocker Noyes, Medical Librarian: Auto Gas and Oil Company, Butte, Montana, to appear before the The Shaping of a Career,” by Bernie Todd Smith. Osler wrote the “Senate Committee on Manufactures.” letter about one year after he left Johns Hopkins University in 1905 to take the position of regius professor of medicine at Oxford Notable contributions: A leading figure in the progressive University in Oxford, England. movement of the 20th century, La Follette held every major political office in Wisconsin, according to the U.S. Senate’s web site. Born Notable contributions: Known as “The Father of Modern in 1855, he grew up in the Town of Primrose, Wisconsin, between Medicine,” Osler may have made his most important contribution New Glarus and Verona. He was elected to the U.S. House of to medicine in the training of medical students, according to the Representatives in 1884 and served there until 1890. Ten years National Institutes of Health (NIH) web site. He pioneered the later, he was elected as the Wisconsin governor and served in that approach of teaching students at the bedside rather than strictly in post until he was elected to the U.S. Senate in 1906. La Follette an academic setting. Osler also is credited with being one of the held his position in the Senate until his death in 1925. During his four men who founded Johns Hopkins School of Medicine, which time in the Senate, La Follette made two unsuccessful attempts opened in 1876. Its companion hospital opened in 1889. Osler was to run for president. Over his political career, “Fighting Bob” had a appointed physician in chief of the hospital and professor of the lengthy list of progressive accomplishments, including pushing for theory and practice of medicine, the NIH web site states. In addition a direct primary system, tax reform legislation, railroad rate control, to his role in founding Johns Hopkins University and Hospital, Osler and other measures known as the “Wisconsin Idea,” collectively wrote what is considered a classic medical textbook, The Principles aimed at weakening the control of party bosses and turning over and Practice of Medicine. It was reproduced in 16 editions and public administration to popularly elected leaders, the Senate’s was referenced long into the future even as medical practices web site states. advanced, according to the NIH web site.

There’s More Online! • Marie Curie • Albert B. Sabin, MD Visit med.wisc.edu/50451 • Harvey Cushing, MD • Albert Schweitzer, PhD to see historic pieces by: • Linus Pauling, PhD • Harper’s Weekly

10 VOLUME 19 • NUMBER 1 Name: Sir Alexander Fleming, MBBS Circa: 1946 Donated by: Michael Kappy, MD ’67, PhD ’67

Fleming penned this letter apparently to thank a person known only as “M. Andre” for returning a passport. It is unknown whose passport Fleming is referring to, but it is likely his own.

Notable contributions: Fleming’s most important contribution came at the intersection of science and medicine. He is credited with discovering penicillin. In 1928, when Fleming returned to his work at St. Mary’s Hospital Medical School in London after a few weeks away at his home in Suffolk, England, he noticed a mold had grown in a petri dish containing Staphylococcus bacteria he left on his workbench. He observed that the bacteria around the mold were dead or absent—a discovery Fleming would later call penicillin. Fleming wrote this letter two years after he was knighted for his scientific contributions in 1944, and the year after winning the Nobel Prize in 1945.

Donors Help Preserve History

At the University of Wisconsin School of Citation Award, he Daniel Albert displayed the pieces in his Medicine and Public Health (SMPH)—with wanted to donate office at the SMPH, where he was a faculty roots back to 1848, when Governor Nelson his collection to member for 24 years. He was the chair Dewey included a medical school in the his alma mater. of the Department of Ophthalmology and newly created University of Wisconsin— “I thought the Visual Sciences, the founding director of it’s natural for history to be relished. gift of history would the McPherson Eye Research Institute and A special collection of letters and be a good thing,” the Frederick Allison Davis professor. autographs from some of history’s most Kappy explains. Michael Kappy, MD ’67, Upon moving his career to the Oregon PhD ’67 influential people in medicine and U.S. Daniel Albert, MD, Health and Science University in 2016, politics reflects that value on behalf of MS ’97, and his wife, Eleanor Albert, Daniel and Eleanor Albert were happy to donors and those who appreciate the gifted to the SMPH, in 2016, a letter add to the SMPH’s collection, he notes. artifacts daily. penned by Abraham Lincoln and an 1862 “When I visit the Dean’s Office, I always “We are so appreciative of the generous Harper’s Weekly illustration of battlefield enjoy looking at the art,” he comments. donors who have given these wonderful surgeons in the Civil War. Years back, gifts to our school,” notes Robert Golden, they donated a rare book collection to the MD, dean of the SMPH. “This collection ties Memorial Library at UW-Madison. together the traditions of history, the arts A noted scholar of the history of and letters, and science in a way that is ophthalmology and medical ethics and both captivating and inspiring.” esteemed for his ocular tumor research, Michael Kappy, MD ’67, PhD ’67—who Daniel Albert has collected historical has a productive research and clinical medical books and relics for decades. career in pediatric endocrinology at the Lincoln’s letter was the key piece in a University of Colorado—donated most of package of items, but it wasn’t the reason the pieces in approximately 2007. he purchased the lot, he notes. After Kappy received the Wisconsin “There was a book I really wanted, and Medical Alumni Association’s 2004 Alumni the letter was the leading item,” he says. Eleanor Albert and Daniel Albert, MD, MS ’97

QUARTERLY 11 FEATURE STORY

On the west end of UW-Madison, the Health Sciences Learning Center (middle), Signe Skott Cooper Hall (bottom left) and Rennebohm Hall (bottom right) house the UW School of Medicine and Public Health, School of Nursing and School of Pharmacy, respectively. The UW School of Veterinary Medicine is a few blocks east. Center for Interprofessional Practice and Education (CIPE) Advisory Council

Jeanette Roberts, PhD, MPH, CIPE director Elaine Mischler, MD, School of Medicine and Public Health Deborah Bebeau, EdD, OTR, Occupational Therapy Program Keri Robbins, MS Ed, Wisconsin Area Health Education Council Ruthanne Chun, DVM, School of Veterinary Medicine Roberta Rusch, MPH, School of Medicine and Public Health Aaron Friedman, MD, School of Medicine and Public Health Tracy Schroepfer, MSW, PhD, School of Social Work Robert Holland, MD, School of Medicine and Public Health Sue Wenker, PT, PhD, MS, Doctor of Physical Therapy Program Jill Jacklitz, MSW, Center for Patient Partnerships, Law School Kevin Wyne, MPAS, MSc, PA-C, Physician Assistant Program Sarah Kruger, DNP, MS, School of Nursing Joseph Zorek, PharmD, School of Pharmacy Beth Meyerand, PhD, School of Medicine and Public Health

12 VOLUME 19 • NUMBER 1 BY JEFF GLAZE

Interprofessional Health Education NEW CENTER FOSTERS TEAMWORK APPROACH

hen Roberts viewed those accreditation standards Yet, more than 40 years later, teamwork University of as a bellwether for other professions. remains a major challenge in hospitals, with WWisconsin- Fast forward to September 2016, and communication posing one of the biggest Madison leaders UW-Madison is celebrating the debut of threats to patient safety, according to the asked Jeanette the Center for Interprofessional Practice National Center for Patient Safety (NCPS). Roberts, PhD, MPH, and Education (CIPE). The UW Schools of For instance, an NCPS review of more in 2013, to devote Medicine and Public Health (SMPH), Nursing, than 7,000 adverse events and close calls in another year to her Pharmacy and Veterinary Medicine are Veterans Administration hospitals found that role as dean of the founding members, and Roberts—who communication failure was the root cause or School of Pharmacy, Jeanette Roberts, recently completed her health policy a contributing factor in 75 percent of cases, PhD, MPH her affirmative fellowship—is the center’s first director. according to a 2015 Report to Congress by response brought with it a deeply held National and local health professions the U.S. Government Accountability Office. condition: creation of a center that would leaders and learners have long discussed In line with its overarching goals foster coordination among health care- the importance of teaching these fields in an to help improve core competencies in related programs throughout UW-Madison. interprofessional way. As early as 1972, an interprofessional health education, the At that time, after a decade leading the Institute of Medicine report, “Educating for CIPE aims to enhance interprofessional school, Roberts was preparing to pursue a the Health Team,” described organizational, communication and overcome causes of one-year Robert Wood Johnson Foundation political, ethical and legal barriers to communication failure. To do so, it will health policy fellowship in Washington, DC, effective, safe team-based patient care. analyze and work to improve communication but the School of Pharmacy needed extra The report urged that academic health throughout the training of health care time to find a qualified candidate to succeed centers “must recognize an obligation to professionals in classroom, clinical and her as dean. engage in interdisciplinary education and extracurricular settings. Also, the school’s recent reaccreditation patient care, and establish regional consortia “We’re beyond the point of arguing brought to the forefront new pharmacy of health professional schools not otherwise that interprofessional health education is standards that emphasize collaboration associated with academic health centers … valuable,” Roberts says. “UW Health risk among various health care professions. to foster educational teamwork.” managers told me that if they hire graduates who don’t have interprofessional language,

QUARTERLY 13 integrated learning systems to transform education and care together. “The ultimate goal is to create better health for patients and populations, but the idea they started rallying around is that we can’t do that unless we change the educational system,” Zorek notes. “That really struck me, partly because I had been a high school social studies teacher.” He continues, “I had all this educational

TODD BROWN/MEDIA SOLUTIONS background, and I gravitated to this idea of The annual Interprofessional Health Education Summit at UW-Madison features break-out sessions the Nexus and how important educational for planners to gather information on what each school and program does, or could do, to incorporate policy changes or curricular changes could cross-professional experiences into their training of health care professionals. be in impacting health care outcomes.” For Zorek, the appeal of moving his or who don’t have this type of knowledge to see CIPE grow into an organization that career to UW-Madison was two-pronged: across disciplines, the health care system is will reform health education to encourage It offered him the chance to make at high risk of negative patient outcomes and better communication and collaboration, and interprofessional practice and education the malpractice suits.” ultimately improve patient care and safety. foundations of a research program, and he Roberts and the CIPE Advisory Council— “The whole point is to graduate would have the opportunity, through CIPE, to which consists of faculty and staff from the collaboration-ready practitioners who are help mold the university’s efforts in this area various member schools (see page 12)— very comfortable and adept at walking into from the ground up. are building the infrastructure to achieve a setting and talking with social workers, He spends a large portion of his time CIPE’s aims; they soon will recruit an physicians, physical therapists and other promoting a better understanding of associate director. Everyone involved hopes health care professionals,” Roberts explains. various health care professionals’ roles and Changing Education to Reflect responsibilities so students are prepared to Health Care Delivery Shortcomings work collaboratively on teams. New Training Module Although he took an unusual path into For example, at the UW School of health care, it wasn’t by chance that Joseph Pharmacy, he has developed a course for An online case study immerses University Zorek, PharmD, ended up at UW-Madison. first-year students that explores numerous of Wisconsin-Madison learners in a life-like Zorek, who’s been an assistant ways pharmacy can be practiced and how hospital setting to show how interprofessional professor in the UW School of Pharmacy pharmacists interact with other health since 2013, spent three years teaching communication breakdowns among a health professionals to strengthen team-based care. in secondary education before attending care team can affect patient outcomes. Zorek notes, “One purpose of the pharmacy school at the University of Illinois Produced through a campus Educational course is to make sure pharmacy students at Chicago. He then completed a two-year Innovation Grant, a team of faculty, staff and understand all of their profession’s roles and pharmacotherapy residency at Texas Tech responsibilities so they can adequately teach students from the UW Schools of Medicine and University Health Sciences Center in Amarillo, other professionals about pharmacy’s roles.” Public Health (SMPH), Pharmacy and Nursing, where he developed a research focus in A CIPE team is developing a related and the Physician Assistant Program developed interprofessional practice and education. course, “Foundations of Interprofessional the interactive module with assistance from Believing that pharmacists’ expertise Education.” It will be offered as a pilot for the UW-Madison Department of Information was vastly underutilized, and searching medical, nursing and pharmacy students Technology. The module is now included in for a framework to address this problem, in fall 2017 and as an elective/selective for the SMPH’s MD curriculum with the goal that Zorek became interested in the work of the students in those programs in spring 2018. all UW-Madison health professions students National Center for Interprofessional Practice Ideally, the course eventually will be available will use the online resource soon, according and Education at the University of Minnesota. for all health professions students. Some That center’s efforts are oriented around the to project leads Shobhina Chheda, MD, MPH, programs have expressed interest in making “Nexus,” which they describe as the interface SMPH assistant dean for medical education, the course a requirement in the future. between health professions education and and Roberta Rusch, MPH, SMPH clerkship At the SMPH, the MD Program’s health care delivery. The Nexus affords an curriculum manager. new ForWard Curriculum emphasizes opportunity to create deeply connected, interprofessional health education and There’s More Online! —Continued on page 39 Visit med.wisc.edu/50452 14 VOLUME 19 • NUMBER 1 Simulated Practice, Real Learning

by Andrea Schmick communicates and works together. For Advanced Life Support+ (PALS+), which example, during a post-simulation debrief, attracts clinicians from around the region. It was a case of respiratory failure. ED nurses get a better understanding of Srinivasan, Scott Hagen, MD ’87, The Children’s Hospital Emergency what takes place in the ICU, and vice versa. and Joshua Ross, MD, have conducted Transport Ambulance team brought the “It opens a lot of doors when it comes emergency response simulations patient to the American Family Children’s to effective function as a team,” Cercone with manikins at several UW Health Hospital Emergency Department (ED). After explains. “A lot comes from a shared pediatric clinics. stabilization, the patient was moved to the appreciation of others’ perspectives.” intensive care unit (ICU) for further care. Strengthening Medical Education After simulations, the team debriefs and Physicians, nurses, residents, Cercone hopes to continue these each participant can share observations, pharmacists, respiratory therapists types of interprofessional and simulation which can further improve care. and child-life specialists were called in activities at American Family Children’s This simulation and debrief model can throughout, as needed. Afterward, they Hospital in the future. be used in many clinical environments to debriefed on how the process could have Srinivasan also is working with the identify latent hazards, test new or existing been even safer and more effective. Clinical Simulation Program to develop a systems and facilitate improvements. The catch? The “patient” was simulation instructor training program. The a manikin, and the scenario was a Building on Simulation in Residency goal is that such a program can optimize simulation. But the learning was very real. and Outreach Programs the growth of simulation in the SMPH’s Simulation has been a key part of the new internship prep course for fourth-year Improving Interprofessional department’s residency and outreach Team Function medical students. programs for several years. The scenario was part of an “There is a real art to conducting an Pediatrics residents strengthen interprofessional simulation project effective debrief so learners achieve the procedural and communication skills between the University of Wisconsin School objective you had intended,” Cercone through weekly sessions at the Clinical of Medicine and Public Health’s (SMPH) notes. “The way to effectively use Simulation Program. Simulation also is Department of Pediatrics, the BerbeeWalsh simulation is to think carefully about what woven into the interactive case-based Department of Emergency Medicine and you are looking to get out of it, because discussions each week. the UW Health Clinical Simulation Program. then you ask the right questions.” Sushant Srinivasan, MD, leads the Each year, the team practices Department of Pediatrics’ Pediatric ED-to-ICU transport simulation multiple times. In 2017, they’re holding a series of simulations focused on rapid response for patients on the wards who need critical- care evaluation. Simulations replicate real-life situations and aim to improve transitions of care. Melissa Cercone, MD, the Department of Pediatrics’ director of simulation, says the projects provide an opportunity to observe how an interprofessional team

A team consisting of a nurse, respiratory therapist and resident responds to a simulated patient while the simulation team observes.

QUARTERLY 15 ALUMNI NOTEBOOK

MELTING POT OF WISCONSIN

W inter Ev ent TODD BROWN/MEDIA SOLUTIONS (8)

isconsin’s winter weather was no Alumni and students mingled as they year-long research fellowship between her match for the warm, welcoming sampled sweet and savory items that third and fourth years of medical school— Watmosphere at the Wisconsin represented the state’s cultural diversity, hosted the French table with WMAA Board Medical Alumni Association’s (WMAA) such as Native American fry bread, braised Member Kyla Lee, MD ’98. Lee serves as Winter Event on February 24, 2017. venison and succotash; and various a preceptor for SMPH medical students in More than 190 guests flocked to German, Scandinavian, Hmong, Latino, her medical practice at Gundersen Health the toasty Fluno Center at University of African, French and Italian delicacies. System in La Crosse, Wisconsin. Wisconsin-Madison, where they were A jazz quartet entertained guests, who “I love attending the Winter Event each greeted by medical students from the traveled from table to table to complete year. It provides unparalleled opportunities UW School of Medicine and Public Health “passports” indicating which foods they for students to meet alumni who beam (SMPH) and by aromas related to the tried and whom they met along the way. with Badger pride and are happy to share evening’s food and beverage theme: Student and alumni pairs hosted food their experiences,” exclaims Maciolek, Melting Pot of Wisconsin. tables, which were arranged by country. calling Lee the best teacher she’s ever For instance, Kimberly Maciolek—an SMPH had. “Dr. Lee is quick with words of Student Ambassador who is completing a encouragement and has an infectious

16 VOLUME 19 • NUMBER 1 smile. Her dedication to teaching was Maciolek says her role as a Student Clockwise from far left (both pages): apparent even at the Winter Event.” Ambassador helps her connect with alumni Food from Wisconsin’s diverse cultural Because their table showcased the for career exploration opportunities. For heritage graced the buffet; Cody Fredrick and Steven Merkow, MD ’80, pose as influence of French culture on Wisconsin, instance, she shares gratitude that Patrick Valerie Mok, MD ’16, takes their photo Lee shared stories about that country’s fur McBride, MD ’80, MPH, donated her and M1Tenzin Atruktsang assists guests; trappers, who were some of Wisconsin’s stethoscope and is serving as a mentor, a Jazz quartet of M4 Nick Vogt, M4 Kusha Rahgozar, M4 Peter Carlson and M4 Mazdak first inhabitants. and that generous donations from alumni Bradberry entertained the crowd; M1 Nikki “The French might not have have funded her Great People Scholarship. Niewold and Patrick McBride, MD ’80, MPH, championed cheese curds, but their cuisine Karen Peterson, WMAA executive pose; Ann Ruscher, MD ’91, Mark Schroeder, was a delicious addition to the menu,” director, says, “Our goal was to make this MD ’79, M1 Melissa Ricker and M3 Maureen Riegert gathered; M3/4 Kim Maciolek notes Maciolek, who also was happy to event fun and easy for guests to sample suggests a food item for guests Peggy meet Meghan Lubner, MD ’03, with whom treats from multiple cultures while meeting McCullough and John McCullough, MD ’76; she has been working remotely on a people and rekindling friendships. We’re M1 Nnenna Ezeh and M1 Chiadika Nwanze research project. grateful for everyone who helped make the review the evening’s passport; M1 Ryan Valk and Richard Van Dreel, MD ’62, visit Winter Event a success.” as they dine.

QUARTERLY 17 ALUMNI NOTEBOOK

Know Your Class Representatives Each University of Wisconsin School of Medicine and Public Health (SMPH) graduating class has one or more class representatives who play an integral role in working with the Wisconsin Medical Alumni Association (WMAA) to plan class reunions. Those featured here and online hope classmates will join them at their reunions in spring 2017.

D. JOE FREEMAN, MD ’52 commercial block into a beautiful, efficient What are your hobbies/interests? space for the public and arts community. I enjoy hunting and fishing with friends and What type of practice are you in now, family members. One time, when I was and where? What SMPH faculty do you remember returning from a hunt in Montana, a fellow After 40 years of introducing clinical the most, and why? doctor asked me, “When are you going to and interventional cardiology to Wausau, I have great respect for most of my teachers move out there?” I answered, “Never. I’m Wisconsin, I retired in 1995 at age 70. and fond memories of the nice dinners glad to be back working.” He was confused I was active in state chapters of professional Dr. Ovid O. Meyer and his wife held for and asked, “Why?” I replied, “It’s the people associations and the WMAA (past president residents and our spouses. that I take care of that I love.” and member of its board and Quarterly Other news editorial board). I served as an SMPH Our children and three of our 14 What are your plans for your reunion? preceptor and as a volunteer clinical grandchildren graduated from UW-Madison. I am looking forward to our 60th reunion assistant professor in the Wausau Family Three of our children hold MDs; one is a from medical school. We are all getting into Practice Residency Program. I helped masters-level RN; and one is a certified that time in life when we look back—the replace two aging Wausau hospitals with a financial planner and certified public future is quite uncertain. It will be great to modern community hospital that has built accountant with an MBA degree. see all of my classmates again. a reputation for outstanding quality. Other updates? What’s your fondest memory of TED FOX, MD ’57 I am 85 years old and have been married for medical school? What type of practice are you in now, 60 years. My wife, Barbara, and I have eight My most notable memory is from my and where? children, who range from 40 to 59 years old. freshman year. I was curled up on a window After a very enjoyable career practicing in Barbara and I often marvel about how fast ledge in the Medical Library, reading and Antigo, Wisconsin, with Dr. John McKenna the years go by. smoking my pipe, when my superhero, and many others, I retired completely Dean William S. Middleton, appeared in my in 2009. face and said, “No smoking in the Library!” SANFORD MALLIN, MD ’57 I gathered my wits enough to say, “Yes sir!” What’s your fondest memory of What type of practice are you in now, medical school? and where? What are your hobbies/interests? Medical school was a challenge for all of us. I retired in 2009 after 46 years in private My hobbies have included spending time We were always reminded that some would endocrinology practice in the Milwaukee, with my family, traveling, backpacking, not make it. That increased the stress factor. Wisconsin, area. My partners and I taught hunting and skiing, but health issues have During our first year, Monte Liebman and I medical students and residents, and I was interdicted some activities. Since my beloved were rushing to class, and he remarked “Fox, a preceptor for the SMPH and a volunteer wife of 70 years, Mary Clare, and I retired, slow down. God is not teaching this class!” clinical professor for the SMPH and Medical we have been dedicated to founding the When we made it to our second year, I found College of Wisconsin. I now provide volunteer North Central Conservancy Trust, establishing it to be less stressful. The last two years were endocrinology care at free health clinics. the UW-Marathon Distinguished Faculty more clinical, and I knew I had made a good Society, and converting an aging downtown choice to pursue a career in medicine.

18 VOLUME 19 • NUMBER 1 D. Joe Freeman, MD ’52 Ted Fox, MD ’57 Sanford Mallin, MD ’57 Kathy Piziali Nichol, MD ’62, MS ’94

What’s your fondest memory of American Academy of Pediatrics (AAP) Board the trip back to where we spent so many medical school? of Directors. I remain active in the AAP and wonderful and hectic days. Our 50th reunion Each year seemed better than the past year. chair one of its national committees. was special, and I hope we can duplicate that I particularly enjoyed my preceptorship with What’s your fondest memory of feeling at our 55th anniversary. Dr. Maurice Whalen in Ladysmith, Wisconsin. medical school? Message to your classmates? What are your hobbies/interests? The Class of ’62 was particularly close, For our 50th reunion, our class raised My hobbies include traveling, reading, partly because we were medical students more than $25,000 for the Great attending concerts and auditing classes. at a chaotic time in the school’s history. People Scholarship Fund in honor of What SMPH faculty do you remember Dean John Bowers had been charged with Dr. Charles Miller, our class leader for years. the most, and why? strengthening the institution. He named many I encourage our class to add to that sum I remember Dr. Will Fey, a psychologist who new leaders and faculty members, including this year. Every year, I receive a thank you led an elective seminar that emphasized Dr. Nate Smith, chair of the Department of note from a medical student who received nondirectional therapy and teaching. Pediatrics. Many faculty in the Department a scholarship. Charlie would be pleased to of Surgery did not agree with some of Dean know what a difference our class is making. What are your plans for your reunion? Bowers’ actions, and this impacted our class In addition to our reunion, I look forward during our first clinical year. to walking around campus, the Chazen Museum of Art and the Farmer’s Market. What are your hobbies/interests? CLASS REPRESENTATIVES My favorite hobbies are reading, cooking and WHO ARE PLANNING REUNIONS Message to your classmates? dining with family members. Also, I knit and Our number of classmates and years to be have taken up Navajo weaving, Nantucket These classes will hold reunions on together are becoming fewer. We have much basket weaving and Amish-style quilting. Thursday and Friday, June 1 and 2, 2017. to be grateful for and many memories to 1952: D. Joe Freeman share. Ted Fox and I hope you’ll join us at What SMPH faculty do you remember our reunion. the most, and why? 1957: Ted Fox and Sanford Mallin Dr. David Smith wrote the definitive book 1962: Kathy Piziali Nichol KATHY PIZIALI NICHOL, on dysmorphia. While he became world MD ’62, MS ’94 renown, he always was very humble and 1967: Mary Ellen Peters warm, a fantastic teacher, and gentle with Half-Century Society: What type of practice are you in now, patients and parents. Many of us strived to John Wyman (Class of ’58) and where? be a little like him, and a high number of our I practiced general pediatrics in Madison classmates entered pediatrics. for 25 years (23 at Dean Clinic). I then What are your plans for your reunion? Visit med.wisc.edu/50453 served as vice president of medical affairs at We’ll have a dinner on Friday night and to see comments from: St. Mary’s Hospital in Milwaukee, Wisconsin, gatherings on Saturday (details to come). • John Wyman, MD ’58 for more than six years and served on the I hope many of us will be able to make • Mary Ellen Peters, MD ’67

QUARTERLY 19 ALUMNI NOTEBOOK

“On Call” Two WARM grads what tell Quarterly they’ve been up to

Don Beno, MD (left), of the Aurora BayCare Medical Center in Green Bay, Wisconsin, is a preceptor for the Wisconsin Academy for Rural Medicine (WARM). He mentored WARM student Hope Villiard in his rural practice. Villiard (MD ’16) has since graduated from the UW School of Medicine and Public Health and is doing a residency.

KATHERINE REIMER, MD ’13

am a general internist of the WARM Program’s cancer, and I spent a year and at Marshfield Clinic in admissions committee. a half getting to know her and IMarshfield, Wisconsin. There, I see patients for preventive her husband during frequent I staff the outpatient resident care and myriad chronic clinic visits and hospitalizations. clinic weekly and work as a conditions—you name it, I see I witnessed the woman’s slow, hospital attending physician it! I teach residents how to steady decline and the pain occasionally. I also direct the manage common outpatient each setback caused her and fourth-year preceptorship complaints, and I periodically her husband. The beauty of and am developing the teach medical students and primary care is the relationship ambulatory acting internship residents about common physicians can build with that will replace the hospital cases. patients and families, allowing months in a way that honored preceptorship. I am the An older woman patient us to approach difficult her life and wishes. She died assistant site director for the holds a special place in situations with empathy and peacefully at home surrounded Wisconsin Academy for Rural my heart. When I was a understanding. I was able by her loving family and in the Medicine (WARM) Program second-year resident, she was to guide the couple through care of hospice. in Marshfield and a member diagnosed with pancreatic the woman’s difficult final

20 VOLUME 19 • NUMBER 1 I’m from the beautiful town the state—aligned perfectly I liked the town, clinic system Additionally, I started a of Eagle River in northern with my goals. By working and people so much that I teaching certificate program Wisconsin, where I’ve always one-on-one with attending joined Marshfield’s staff. through the Society of General enjoyed the rural lifestyle and physicians, WARM students I am active with the state Internal Medicine, and I people. I planned to return to gain experiences that are hard and national chapters of the envision education as an a small Wisconsin town after to come by in large centers. American College of Physicians important part of my future. college, so when I decided to Through the WARM and serve as Marshfield pursue medicine, I wanted to Program, I spent my third and Clinic’s residency and clinic choose a program that would fourth years of medical school representative with the state prepare me for the unique at Marshfield Clinic, where chapter. I also am a member challenges faced by rural I also completed my residency. of the clinic’s health policy primary care physicians. The I feel fortunate that my training committee and have advocated WARM Program—through in a rural, community-based for patients and the medical which medical students train in center helped me develop into profession in our state and rural communities throughout a capable rural internist. Also, national capitals.

TIM KUFAHL, MD ’12

am a family physician at grandparents of the family somewhere in between rural St. Luke’s Hospital and St. plan their advanced directives. and urban environments when ILuke’s Medical Arts Clinic in There’s a distinct feeling of we chose to live in Duluth. downtown Duluth, Minnesota. pride that comes from having I am a member of the My day typically begins multiple family members trust Minnesota Academy of with inpatient hospital rounds you with their care. Family Physicians, as well followed by clinic. As a family I chose to enter the as its national and local physician, I see patients of Wisconsin Academy for Rural Duluth chapter. I occasionally all demographics; additionally, Medicine Program so I could moonlight in emergency rooms about 25 percent of my experience both medical in rural northern Minnesota, communities, which offers practice involves addiction training and the lifestyle in a and I also have special students a balanced medical medicine and medical rural setting. I did my residency interests in addiction medicine education compared to the adjunct therapy. in North Minneapolis at the and wilderness medicine. typical academic setting. It My most memorable University of Minnesota’s I would absolutely exposes them to both the moments as a doctor stem North Memorial Program. The encourage any medical student advantages and challenges from the ability to provide urban setting was a great interested in a career in rural of rural communities so they longitudinal care for entire complement to the rural medicine to consider the will be confident in their families. I cherish taking care experiences I had through WARM Program. In addition future careers as primary of generations of families, the WARM Program, and both to exceptional medical care doctors. whether it’s seeing a child for helped me understand health training at the UW School of his or her first well-child visit, and its socioeconomic factors Medicine and Public Health, seeing the child’s parents for in a unique light. Interestingly, the WARM Program offers annual physicals, or helping my wife and I ended up unique experiences in rural

QUARTERLY 21 ALUMNI NOTEBOOK

CLASS NOTEScompiled by Andrea Larson

We want to hear from you! CLASS OF CLASS OF med.wisc.edu/shareyournews 1960 1975 CLASS OF Leslie M. Klevay published in Nutrition Ada Fisher was elected to her third Research Reviews a summary of his theory term on North Carolina’s Republican National 1955 that copper deficiency causes ischemic heart Committee, which she represented at the Lawrence M. Field described the disease. The most general explanation of the 2016 Republican National Convention. Fisher American Society for Dermatologic Surgery illness’ epidemiology and pathophysiology, it also has served as a corporate physician (ASDS) Board’s approval of the ASDS- incorporates theories on fetal programming, for Amoco Oil Company, occupational affiliated International Fellowship Program homocysteine and iron overload. health service line director at the VA during the society’s 2016 annual meeting. Medical Center-Salisbury, member of her Field outlined the lifelong efforts many CLASS OF community’s County Board of Education, international dermatologic surgeons have and columnist and blogger for periodicals. dedicated to educating others, as well as the 1970 She has received numerous honors, including being named among the 10 future impact the fellowship programs will Sandra Osborn donates blood regularly have on dermatologic surgery around the in honor of Kay Heggestad—who died in Outstanding Young Women in America in world. The International Fellowship Program January 2017—to honor her wish for people 1984. She attended the winter meeting aims to assist international physicians in who want to make a donation in her memory. of the Republican National Committee in developing and implementing academically Washington, DC, and the 2017 inauguration rigorous dermatologic surgery fellowships. of President Donald Trump.

IN MEMORIAM

Phillip R. Rand, MD ’44 R. Walter Schroeder, MD ’53 Jean Lang, MD ’59 Carl E. Olson, MD ’69, PG ’75 San Diego, California Pensacola, Florida Mequon, Wisconsin Milwaukee, Wisconsin May 16, 2015 September 14, 2016 January 19, 2017 February 5, 2017

Archie G. Britt, MD ’46 Glen J. Stuesser, MD ’53 Joseph Syty, MD ’59 Kay A. Heggestad, MD ’70 La Crosse, Wisconsin Verona, Wisconsin Madison, Wisconsin Madison, Wisconsin February 20, 2016 October 29, 2016 November 26, 2016 January 13, 2017

Verona L. Botte, MD ’47 John E. Kippenhan, MD ’54 Johan A. Mathison, MD ’61 Richard D. Larson, MD ’70 San Diego, California San Jose, California Oshkosh, Wisconsin Dandridge, Tennessee (Death Date Unknown) July 13, 2016 February 23, 2017 December 14, 2016

Roland R. Liebenow, MD ’48 David L. Morris, MD ’54 John R. Marshall, MD ’64 Peter W. Burns, MD ’82 Watertown, Wisconsin La Crosse, Wisconsin Waunakee, Wisconsin Fort Myers, Florida December 2, 2016 February 1, 2017 November 17, 2016 October 17, 2016

C. Weir Horswill, MD ’52 Robert F. Douglas, MD ’55 Eric J. Wedell, MD ’67 Thomas R. Singer, MD ’82 Arlington Heights, Illinois Neenah, Wisconsin Cheyenne, Wyoming Portage, Michigan September 12, 2016 January 24, 2017 October 29, 2016 October 28, 2016

John L. Coryell, MD ’53 Elmer R. Hermann, Jr., Zachary Clark, MD ’13 Cheyenne, Wyoming MD ’59 Madison, Wisconsin December 3, 2016 Hendersonville, N. Carolina March 6, 2017 October 10, 2016

22 VOLUME 19 • NUMBER 1 Christopher Larson recently received CLASS OF Wisconsin Affiliate of Reach Out and Read, the Lions Eye Bank of Wisconsin (LEBW) an early childhood literacy program based in Knight of Sight Fellowship. LEBW President 1981 primary care clinics. She also serves on the Jerry Wille presented him with the award board of directors for the Wisconsin Medical Marc Williams was inducted as a at the Sheboygan (Wisconsin)-Area Lions Society and the advisory council for the fellow into the American College of Medical Eye Bank Support Group annual meeting. Wisconsin Council on Immigration Practices. Informatics in November 2016 during the Larson grew up in Sheboygan and returned American Medical Informatics Association there after he earned his medical degree annual symposium. The event presents CLASS OF and completed an ophthalmology residency leading-edge scientific research on at UW Hospital and Clinics. He has practiced 2009 biomedical and health informatics in more ophthalmology for 39 years and founded than 100 scientific sessions. It presents work Joseph Weber moved back to Wisconsin Larson Eye Care in Sheboygan. He has from across the spectrum of informatics. in summer 2016 following a general surgery promoted the Lions Club mission through Williams practices at Geisinger Health residency at East Carolina University in North his efforts to expand the corneal donor System in Danville, Pennsylvania. Carolina and a fellowship in breast surgical and transplant program, perform corneal oncology at Memorial Sloan Kettering Cancer transplant surgery and lecture about the CLASS OF Center in New York. He joined Aurora Health importance of the Lions’ efforts to enhance Care in Milwaukee, Wisconsin, as a breast vision through screenings, vision care and 2001 surgical oncologist. Weber and his wife, ophthalmic surgery. Larson’s name will be Dayna, welcomed a son, Wolfgang Johann permanently displayed on the LEBW Knight of Wendy Molaska joined the UW Weber, into the world in October 2016. They Sight Wall of Honor, and he will be recognized Department of Family Medicine and are happy to be living in Bayside, Wisconsin, in the organization’s next annual report. Community Health faculty in early 2016. She near friends and relatives. is the co-chair of the Advisory Council for the

GOODBYE DEAR FRIEND: DONN D'ALESSIO, MD (PG ’62, ’65)

Donn D’Alessio, MD (PG ’62, ’65)— As department chair, D’Alessio who was chair of the University of nourished collaborations with the Wisconsin School of Medicine and Public Wisconsin Department of Health to Health’s (SMPH) Department of Preventive create student research opportunities Medicine (now called the Department of and increase the public health impact Population Health Sciences) from 1981 to of research. He helped create the MS 2000—passed away in December 2016. Program in Epidemiology, which graduated Upon his retirement in 2000, D’Alessio many students who established successful was named an emeritus professor. epidemiology careers. Also while he was D’Alessio earned his medical degree chair, the department restructured its three at Cornell University, completed residency master’s degree programs into the MS/ training at UW Hospital and Clinics and PhD Population Health Graduate Program, the University of Illinois, and served in the the first such U.S. doctoral program in the involvement in student affairs, including the Epidemic Intelligence Service at the U.S. emerging field of population health. He also department’s student organization. Centers for Disease Control and Prevention. guided the department’s name change. “Dr. D’Alessio’s epidemiological His research spanned infectious disease To celebrate D’Alessio’s contributions, research was remarkable for its breadth epidemiology and the epidemiology a department graduate student is selected and path-breaking explorations of the of chronic diseases. It included the by peers each year to receive the Donn role of infectious disease processes in establishment of the National Institutes of D’Alessio Student Award. Criteria include the etiology of chronic conditions,” says Health-funded Wisconsin Incidence Cohort excellence in research and academics, Maureen Durkin, PhD, DrPH, professor and Registry of Type I Diabetes and other outstanding activities as a community interim chair, Department of Population population-based cohorts. member, and knowledge sharing and Health Sciences.

QUARTERLY 23 ALUMNI NOTEBOOK

GOODBYE DEAR FRIEND: JOHN F. “JACK” FOWLER, PHD

John F. “Jack” Fowler, PhD died in dose fractionation to maximize therapeutic December 2016, at his home in London. effects and minimize tissue damage. He was 91. Fowler was instrumental in helping the Fowler was a professor emeritus in the DHO earn its first program project grant for Departments of Human Oncology (DHO) cellular proliferation and radiosensitivity and Medical Physics at the University of research, assisting in the development Wisconsin School of Medicine and Public of TomoTherapy and helping establish Health (SMPH). UW-Madison as a leader in brachytherapy. After earning a PhD in radiation physics, Former collaborator Bhudatt Fowler spent several years in hospital Paliwal, PhD, professor emeritus, DHO, physics before transitioning into research says, “His dynamic personality immediately at the MRC Radiotherapeutic Research Unit produced a spark. When I was a junior at Hammersmith Hospital (U.K.). For nearly assistant professor, Jack made me feel fortunate to have Jack on the faculty at 20 years, he directed the Gray Laboratory so excited, as if I were a passenger in the UW-Madison. He made highly impactful (U.K.). He served at UW-Madison from seat of a Grand Prix racecar, gulping for air, contributions to the field of radiation 1988 to 1994 and 1999 to 2003. as Professor Fowler drove like the wind. oncology. He was a wonderful researcher, Fowler was one of the founders of Throughout my career, his guidance and collaborator and friend who was modern radiation biology. He also bridged collaboration continued. We will miss him.” enthusiastic about everything he did the gap into clinical care as he advanced Paul Harari, MD, DHO chair and Jack in life.” Fowler Professor, says, “We were very

GOODBYE DEAR FRIEND: OLIVER SMITHIES, PHD

Oliver Smithies, PhD, who shared the Much of the work for which Smithies 2007 Nobel Prize for his work enabling was recognized was performed at scientists to manipulate DNA in a way UW-Madison. that allowed the addition or subtraction “One of my proudest accomplishments of genes from the mouse genome, died was helping to attract him here,” said the in January 2017, in Chapel Hill, North late UW-Madison Professor of Genetics Carolina. He was 91. James Crow, PhD, in a 2007 interview. Smithies was a professor of genetics at “Everything he did had a characteristic the University of Wisconsin-Madison from touch of originality.” 1960 to 1988, leaving to join the faculty at Smithies’ work revolutionized the University of North Carolina School of mammalian genetics, allowing scientists to

Medicine. He was recognized by the Nobel study thousands of genes and their effects, CHAPEL HILL AT CAROLINA UNIVERSITY OF NORTH Prize committee—along with researchers and providing insight into mutations and Yin adds, “What is not generally Mario R. Capecchi, PhD, and Briton Sir changes that underpin disease and health. appreciated is how much he loved to Martin J. Evans, PhD. Working independent “Oliver was the quintessential scientist,” teach. For him, teaching was an intimate of them, Smithies devised a technique says Jerry Yin, PhD, UW-Madison professor part of the process of scientific discovery. that involved introducing a desired genetic of genetics. “He loved asking big questions, It gave him reasons to scour the old and change into a mouse by injecting altered the process of trying to answer parts of the new literature, to make novel connections stem cells into mouse embryos. Mice born questions, positive results, and the process between disparate fields, to ‘think out of the altered embryos could then be bred of overcoming experimental barriers.” loud.’ Most of all, it gave him great joy.” to produce progeny with altered genes.

24 VOLUME 19 • NUMBER 1 STUDENT LIFE

M1 STUDENTS WRITE AND PLEDGE Class Code of Honor

ntering medical student classes at • Remain cognizant of our roles as clinicians • Conduct ourselves with the honesty and the University of Wisconsin School and members of society, and respect our integrity that we would expect from our Eof Medicine and Public Health write privileges and limitations in both. own physicians. an honor code to guide them through their To our teachers, we will: • Support and inspire each other to reach our training and careers. In January 2017, M1s Respect your time, expertise and experience. full potential. pledged their code, which follows: To honor your investment, we commit to being • Appreciate the myriad backgrounds, To our patients, we will: life-long learners by embracing intellectual experiences and beliefs that each individual • Embody professionalism by respecting their curiosity in pursuit of research, education contributes to the group dynamic, thereby TODD BROWN/MEDIA SOLUTIONS (3) time, backgrounds and individual needs. and patient care. In seeking personal growth, nurturing an environment of mutual respect • Continue to build on our medical education we will welcome a dialogue of constructive and inclusion. throughout our career to learn from our feedback. To show our gratitude, we pledge to To ourselves, we will: patients and for our patients. work hard, stay engaged and remain optimistic Recognize that our patients’ well-being is • Foster a culture of compassionate in the face of challenges. We will strive to connected to our well-being. We pledge to: communication that values the autonomy of continue your legacy both in the classroom • Prioritize our physical, spiritual, mental and each person. and in our clinical practice. emotional well-being. • Advocate for equitable and high-quality To our classmates/colleagues, we will: • Recognize our limits and appreciate our care, within our clinical duties and in our Foster a vibrant learning community by strengths. communities. pledging to: • Maintain integrity and stay true to our • Cherish the unique privilege of serving • Approach our learning and interactions in own beliefs. patients with humility. the classroom, clinic and community with • Be mindful and enjoy the journey. To our communities and society, we will: compassion and empathy and encourage • Cultivate our relationships and our support • Work in solidarity to eliminate health care these qualities in each other. systems that sustain us. disparity. • Invest in the well-being of our classmates • Find balance between important aspects of • Act as partners in the promotion of well- by facilitating an environment of optimism our lives. being, with an understanding of the social and acceptance. • Be kind to ourselves. determinants of health. • Develop ourselves personally and Recognizing the responsibility of medical • Proactively maintain lines of communication professionally not only for our own benefit training and practice, we accept these between patients and providers, supporting but also for that of our patients and tenets as our solemn responsibility. To cultural and systemic engagement. colleagues who depend upon us. the best of our abilities, we promise to hold ourselves and each other accountable to the ideals set forth here.

QUARTERLY 25 ALUMNI PROFILE

A Career Dedicated to Patient- Centered Care JOHN DRAWBERT, MD ’80

26 VOLUME 19 • NUMBER 1 by Masarah Van Eyck “From the start, our mantra was excellent SMPH classmate Patrick McBride, MD ’80, care at a reasonable rate,” recalls Drawbert. MPH, serving as a groomsman, as Drawbert sk John Drawbert, MD ’80, what “We felt we could do that because we didn’t did in return when McBride got married. The accounts for OakLeaf Surgical have the kind of overhead some of the larger two couples have remained fast friends. A Hospital’s extraordinary patient groups had.” Drawbert and his wife returned in 1986 satisfaction rankings, and he’ll tell you it’s Today, the 30-bed facility includes to their home state’s Chippewa Valley, where about being present. seven surgical suites, two GI suites and a they planned to live for a few years before “Each patient expects that when a doctor pain management center. Its 54 affiliated moving to Madison. is spending time with him or her, that’s the surgeons span 15 specialties and offer “But we loved Eau Claire and decided to doctor’s only priority at that moment,” says overnight and outpatient procedures. stay,” Drawbert notes. Drawbert, an orthopedic surgeon and sports While OakLeaf merged its operations with Three children and 31 years later, they medicine specialist who helped found the National Surgical Healthcare in 2004, its are committed community members. Both Altoona, Wisconsin, specialty facility. “It determination to provide patients with have served on boards for UW-Eau Claire comes from the top. Our CEO, our CFO, our affordable, quality care has not wavered. and its foundation. Helen Drawbert has been head nurse, they all translate to those who After all, Drawbert reasons, “Patients are a member of the Altoona School Board for 15 work for them that the most important thing paying big bucks for medicine nowadays. It years, including four years as its president. is the experience each patient has here.” should be a great experience and it should Drawbert and his colleagues also have That formula put OakLeaf on the be a personal experience.” participated in several orthopedic surgery map. Since the hospital opened in 2001, medical missions in Vietnam. Consumer Reports has named it “Best in the The Roots of Innovation Most significantly, the community benefits Nation” for patient experience, and in federal Drawbert is no stranger to innovative from Drawbert’s passion for sports medicine. surveys, OakLeaf received a “highest overall” medicine. As a high school and college As the team physician for UW-Eau Claire’s patient satisfaction ranking. In 2016, the athlete who endured sports-related injuries, Blugolds since 1987, Drawbert also is the Centers for Medicare and Medicaid Services the fledgling sports medicine specialty medical director of the university’s Athletic listed OakLeaf among 251 hospitals—from intrigued him when he was a medical student Training Education Program, which prepares more than 3,500—with a five-star rating. at the University of Wisconsin School of students to serve as certified trainers and OakLeaf’s services are competitively Medicine and Public Health (SMPH). athletic health care providers. Over the past priced. Drawbert says total knee and hip “In my M4 year, sports medicine 30 years, Drawbert and his partners have replacements there average several thousand was barely heard of,” he remembers. provided more than $3 million to support the dollars less than at competing places. “But UW-Madison had Dr. Bill Clancy, an training program and shared their guidance “You can do very well if you minimize the orthopedic surgeon, and spending time with and expertise. Its trainees gain valuable bottom line and maximize the quality of the him piqued my interest.” hands-on experience as they care for student patient experience,” Drawbert maintains. William Clancy, Jr., MD, was a pioneer athletes at the area’s 14 high schools. “The rest will follow.” in anterior cruciate ligament (ACL) But in the end, Drawbert says, “Our goal In an industry that seeks healthy patients reconstructive surgery and an avid athlete. is to provide good care here for athletes.” and healthy profits, charging less for He founded the UW Health Sports Medicine better care may seem counterintuitive. But Program in 1974, a few years before OakLeaf’s founders never felt that way. Drawbert entered the SMPH. “Our philosophy has been that if we During Drawbert’s orthopedic surgery made a great product and charged less than residency at the University of Kentucky, he others, we’d be successful,” says Drawbert, was on the team that treated the Kentucky who has been a hospital leader and the chair Wildcats. His next move was to Salt Lake of the OakLeaf Board of Directors City, where he pursued a sports medicine since 2006. fellowship in knee and shoulder surgery. The hospital and its philosophy have Wisconsin Ties roots in the 1990s, when large health clinics During medical school, Drawbert dated were entering the area. Under the leadership a fellow Madison native, Helen (Sivertson), of general surgeon Steve Immerman, MD, whose father—the late Sigurd Sivertson, Drawbert and a few colleagues began MD ’47—was an SMPH assistant dean at to look for a way to continue to practice the time and retired as an emeritus professor independently. They opened a small of medicine. Soon after Drawbert earned ambulatory surgery center in 1997. his medical degree, the couple wed—with Helen Drawbert and John Drawbert, MD ’80.

QUARTERLY 27 SPOTLIGHT

SAFDAR HONORED ALLEN-HOFFMANN SONDEL WINS AWARD WITH PRESIDENTIAL RECEIVES AWARD AT FOR PIONEERING EARLY CAREER AWARD WHITE HOUSE CANCER RESEARCH

Nasia Safdar, Lynn Paul Sondel, MD, PhD, Allen-Hoffmann, MD, PhD ’75 received the PhD, received a (PG ’80)—the Presidential Early Tibbetts Award Reed and Carolee Career Award at a White House Walker Professor for Scientists ceremony in in Pediatric and Engineers January 2017. Oncology at the (PECASE) in The annual University of January 2017. awards are given Wisconsin School The award is considered the highest honor by the U.S. Small Business Administration of Medicine and Public Health (SMPH) and bestowed by the U.S. government on science (SBA) to recognize outstanding small, UW Carbone Cancer Center (UWCCC), and and engineering professionals in the early high-tech businesses that have significantly director of research, Division of Pediatric phases of their independent research impacted society and the economy Hematology, Oncology and Bone Marrow careers. through instrumental research and Transplantation, SMPH Department of Recipients are selected for their pursuit development. Stratatech and its founder, Pediatrics—was awarded the top prize in of innovative research at the frontiers Allen-Hoffmann—a professor in the cancer immunology. of science and technology and for their University of Wisconsin School of Medicine The Society for Immunotherapy of Cancer commitment to community service as and Public Health’s (SMPH) Department of (SITC) bestowed upon Sondel its Richard demonstrated through scientific leadership, Pathology and Laboratory Medicine—were V. Smalley, MD, Memorial Lectureship public education or community outreach. recognized for their focus on advanced skin Award for decades of work in developing Safdar is an associate professor and regeneration therapies. immunotherapies for childhood cancers, vice chair for research in the University of The Stratatech Corporation, a especially neuroblastoma. Sondel also Wisconsin School of Medicine and Public UW-Madison spin-out company recently has led scientific policy through multiple Health’s (SMPH) Department of Medicine, acquired by Mallinckrodt Pharmaceuticals, national roles. and associate chief of staff for research has grown from five to more than 50 “This award is well-deserved for Dr. at the William S. Middleton Memorial employees and has developed advanced Sondel’s outstanding career, which has Veterans Hospital. regenerative medicines such as the seen great improvement in the outcomes “VA investigators represent a small but StrataGraft® and ExpressGraft™ human for children with cancer,’’ says Howard highly regarded subgroup of the PECASE skin substitute products. Bailey, MD, UWCCC director. “Through his awardees. This places her in the top echelon Every year, hundreds of companies work in the lab and clinical trials, he has of investigators within the VA,” says Alan participate in the Small Business Innovation helped usher in new treatments that are Bridges, MD (PG ’89), professor (CHS), Research (SBIR) Program. Of those, some saving the lives of children everywhere.” Department of Medicine, and chief of staff, stand out as representative of the spirit and Sondel’s research emphasizes the William S. Middleton Memorial Veterans intent of the program. The SBA recognizes translation of laboratory innovations into Hospital. those companies with the Tibbetts clinical progress. His laboratory has pursued Safdar’s research focuses on reducing Award. Named after Roland Tibbetts, the biology of graft-versus-leukemia hospital-acquired infections, particularly the acknowledged father of the SBIR reactions, activation of antitumor immune those by antibiotic-resistant bacteria. She Program, the prestigious awards recognize destruction with Interleukin-2 and the use of has published more than 187 articles in individuals, organizations, firms or projects tumor reactive monoclonal antibodies and peer-reviewed journals and mentored many that made a visible technological impact on immunocytokines to facilitate tumor killing by students, residents, fellows and junior the socio-economic front and exemplify the leukocytes. faculty members. very best in SBIR achievements. “Dr. Sondel has been a tireless champion It has been 15 years since a Wisconsin of investigating immunotherapy approaches company has received a Tibbitts Award. to combat pediatric cancers,” states Lisa H. Butterfield, PhD, SITC president.

28 VOLUME 19 • NUMBER 1 CHAPMAN’S GRANT TO BROW ELECTED MOORE RECEIVES FUND NEUROLOGICAL AS A FELLOW BY TWO RESEARCH RESEARCH SCIENTIFIC SOCIETY AWARDS

Edwin The Darcie Moore, Chapman, American PhD, assistant PhD, received Association professor in the a new federal for the Department of grant—an R35 Advancement of Neuroscience at Research Program Science (AAAS) the University of Award, from the recently elected Wisconsin School National Institute David Brow, of Medicine and of Neurological PhD, as a fellow. Public Health Disorders and He was among five University of Wisconsin (SMPH), has received two awards for Stroke (NINDS), part of the National Institutes faculty members to be elected. her research. of Health—designed to support long-term A professor in the Department of She was recently honored internationally research in the laboratories of some of Biomolecular Chemistry at the UW when the Society for Neuroscience the country’s most creative and productive School of Medicine and Public Health, awarded her the Peter and Patricia scientists. Brow was chosen for his contributions to Gruber International Research Award in A professor in the Department of the field of RNA biology, particularly for Neuroscience. The award and its related Neuroscience at the University of Wisconsin determining the structure and function of funding—supported by the Gruber School of Medicine and Public Health macromolecular machines responsible for Foundation—recognize scientists for (SMPH), Chapman and members of his eukaryotic gene expression. outstanding research and educational lab study how neurons communicate, Election as an AAAS fellow is pursuit in an international setting. particularly how they send chemical recognition by peers for distinguished Moore also received a 2017 Sloan signals to communicate with one another. contributions to advance science or its Research Fellowship from the Alfred P. Their new focus is on fusion pores, which applications. Sloan Foundation. These fellowships honor mediate the release of neurotransmitters Founded in 1848 and based in early-career scholars whose achievements and play a key role in neurological, mental Washington, DC, the AAAS is the world’s mark them as the next generation of and endocrine function. This research will largest general scientific society. It scientific leaders. Each winner receives a provide new insights into the mechanisms includes nearly 250 affiliated societies and monetary fellowship to further his or her that mediate membrane fusion and could academies of science, serving nearly 10 research. The 2017 fellows represent a lead to treatments for neurological diseases million constituents. diverse variety of research interests. in which too much, or too little, hormone and Additionally, in 2016, Brow was “Through their achievements and neurotransmitter release occurs. elected as a fellow in the American ambition, these young scholars are The new R35 grant supports the overall Academy of Microbiology and earned the transforming their fields and opening up research program of scientists, which in the UW-Madison Chancellor’s Distinguished entirely new research horizons. We are case of the Chapman lab includes a variety Teaching Award. proud to support them at this crucial stage of projects that touch on topics ranging from Brow’s lab focuses on how the of their careers,” says Paul L. Joskow, PhD, synaptic plasticity to how Botox affects cells. chemical properties of RNA and protein president, Alfred P. Sloan Foundation, a The grant provides funding for five years have been exploited by evolution to enable philanthropic, not-for-profit grant-making and may provide a three-year extension. complex biological processes, such as institution based in New York City. Since 2005, Chapman also has pre-mRNA splicing and transcription Moore’s research focuses on how had support from the Howard Hughes termination. They use the power of and why somatic stem cells dysfunction Medical Institute. brewer’s yeast genetics, genomics and with age, with the goal of developing biochemistry to explore the workings of methods to improve or rescue aging in two biological nanomachines. somatic stem cells.

QUARTERLY 29 HEALER’S JOURNEY

To Zanzibar by Motor Car: Teaching Complex Information through Colorful Mnemonics

nemonic phrases help facial nerve: temporal, zygomatic, people learn. They can buccal, mandibular and cervical. Mtake many forms, including The students reached out to local acronyms and interesting sentences Madison artists, including 100state that use the first letter of each word artists-in-residence Christian in the phrase. They are especially Grooms and Ady Stahl, for their take useful for medical students, who on these classic mnemonics. must learn to quickly absorb massive “Medicine is this abstract amounts of complex information concept to many people,” says during their education. Jimmy Xu, MD ’16, who organized a band made up of medical Medical students at the University the project just before he completed students, has been a musical staple of Wisconsin School of Medicine and medical school. “But it’s also weird for a few decades. Public Health (SMPH) and Medical and strangely wonderful, and This focus on art is uplifting, College of Wisconsin, along with we wanted to share that side of according to Caitlin Regner, MD ’16. local artists, applied the humanities medicine with people.” “Art, in all its forms, re-inspires to medicine as they created The movement to find art in our sense of purpose in medicine To Zanzibar by Motor Car, an art medicine (and vice-versa) has and allows us to connect to the book of medical mnemonics. expanded recently. The SMPH has human parts of ourselves so we can The art was created in a variety joined other medical schools—such reach out and care for the human of media, such as digital pen, collage as Harvard, Stanford, Yale and Johns parts of our patients,” she notes. and acrylic on canvas, and the Hopkins—that offer opportunities for A percentage of the proceeds mnemonics cover a broad range artistic expression through dance, from To Zanzibar by Motor Car of subjects from cranial nerves to music, literature, poetry and painting. go to the Wisconsin Medical Alumni characteristics of acute cholecystitis. For example, the Internal Association to benefit future medical The book’s title, for example, is a Medicine Residency Program offers students with merit and need- mnemonic for the branches of the trips to the UW-Madison Chazen based scholarships. Museum of Art, and the Arrhythmias,

4P’s of Lichen Planus

AUTHOR Erin Chung

MEDIUM Collage

Lichen Planus is a condition that affects skin, mucous membranes, and nails. It is characterized as Pruritic (itchy), Purple, Polygonal, Papules.

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30 VOLUME 19 • NUMBER 1 Ewing Sarcoma

AUTHOR Alex Connelly

MEDIUM Ink and Colored Pencil on Paper

Most cases of Ewing Sarcoma are caused by a translocation between chromosomes 11 and 22. Which equals 33 aka the number of the greatest Knicks player in history - Sir Patrick Ewing.

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NAVEL

AUTHOR Yi Ding

MEDIUM Assemblage

NAVEL describes the order of structures in the femoral triangle, an important anatomical landmark. Starting lateral to medial there is the femoral Nerve, Artery, Vein, then an Empty space, and finally Lymphatics.

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To Zanzibar By Motor Car

AUTHOR Ady Stahl

MEDIUM Ink and Colored Pencil

Ahh. We love the way this one rolls off the tongue. It describes the branches of the facial nerve (one of those cranial nerve ruffians we mentioned earlier that lets you wink and smile). Temporal. Zygomatic. Buccal. Mandibular. Cervical.

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QUARTERLY 31 CONNECTIONS

Wi2, Orion Sign Landmark Agreement for Treatment Discovery

by Andrew Hellpap of Wisconsin-Madison, and particularly the UW School of Medicine and Public wo years in the making, a non-profit Health,” notes Richard Moss, PhD, SMPH company affiliated with the University senior associate dean for basic research, Tof Wisconsin School of Medicine biotechnology and graduate studies. and Public Health (SMPH) and a Finnish “We are all committed to the idea that pharmaceutical company have partnered to there is tremendous need for improved develop novel cancer treatments. clinical care and better patient outcomes for The Madison-based non-profit— oncologic diseases.” Wisconsin Technology Innovation Initiative, Once a target is identified, a contract will commonly called Wi2—and Orion Pharma be agreed upon between Orion and Wi2. Any of Espoo, Finland, signed a collaborative proceeds from the discovery would be split agreement in December 2016 that engages between Orion and Wi2 at a rate that will Orion in the development of treatments be negotiated in advance for each target. based on discoveries of new therapeutic Wi2’s share of proceeds will be reinvested in targets by UW Carbone Cancer Center possible science—the best science in the research done at the SMPH. investigators. world—and the patient care; and when “This is an area (pharmaceuticals) “We view this agreement as something we do this in the—ethical, moral and where you have to combine the best that is very important for the University societal perspective—right way, it also

32 VOLUME 19 • NUMBER 1 will turn into company prosperity,” says One of Orion’s signature pharmaceutical Reijo Salonen, MD, PhD, Orion senior vice products is Stalevo, a drug combination to president, pharmaceutical research and treat Parkinson’s disease, which is marketed development, and chief medical officer. by Novartis. “We are lucky here that we are able to The current model of financing research combine those four things, and we hope to and development is not working, according do it together with (Wi2), now and in to Salonen, making collaborations with the future.” academic research institutions a logical step, Following the signing ceremony, Orion as the company has done previously with a executives and SMPH administrative leaders German university. attended presentations from Carbone Cancer In the United States, UW-Madison offers Center researchers that highlighted the latest Orion a combination of discoveries and advances in cancer research at the SMPH. capabilities needed to develop new cancer treatments, Salonen says. The mechanism “We view this agreement as for the collaboration is Wi2. something that is very important for The corporation is aligned with Howard Bailey, MD (standing), UW Carbone Cancer the University of Wisconsin-Madison, UW-Madison for charitable, scientific Center director, describes the center’s latest research and particularly the UW School of and education purposes. In this case, advances to Orion representatives who traveled to Medicine and Public Health. We are the purpose is to support the transition Madison to discuss the partnership. all committed to the idea that there into the marketplace of useful technology is tremendous need for improved developed at UW-Madison and other clinical care and better patient research institutions. that has not been heard of in the world— outcomes for oncologic diseases.” Additionally, Wi2 actively develops in a way that is revolutionary.” technological innovations to the point that The ability to bring important medical Orion currently reports about $1.2 to intellectual property protection is merited. discoveries to the clinic is vital to helping $1.3 billion in revenue, and contributes about “The whole basis for the best R & D is the patients, Moss notes. $120 million into research and development. best science,” Salonen says. “So, how about “We are optimistic about what will come Most of that funding is tied up in current going to try and make a truly collaborative about as a result of this collaboration,” projects, Salonen says. effort with academics, own jointly the he concludes. projects, and work with them in a fashion ANDREW HELLPAP (2) ANDREW HELLPAP

Left to right: Richard Moss, PhD, and Reijo Salonen, MD, PhD, sign the agreement between Wi2 and Orion, as Antti Haapalinna, PhD, Orion vice president for research and development, looks on.

QUARTERLY 33 LEADER Q&A

Mission: Diversity and Inclusion BRIAN GITTENS, EdD ASSOCIATE DEAN FOR HUMAN RESOURCES, EQUITY AND INCLUSION

n January 2016, the University The new office’s main functions George Washington University in of Wisconsin-Madison School include ensuring that all initiatives Washington, DC. Iof Medicine and Public Health related to human resources service Gittens has more than 26 years (SMPH) chose Brian Gittens, EdD, delivery and strategic equity, of experience in operational and as the associate dean for its new diversity and inclusion also focus on administrative human resources, Office of Human Resources, Equity development of a diverse workforce, primarily at major universities. He and Inclusion. The former iteration Gittens notes. is a certified senior professional of of this department served a strictly He earned his EdD degree in human resources and a graduate human resources function. It higher education administration, of the Association of American is undergoing a reorganization with a research focus on Medical Colleges Healthcare to include equity and inclusion. leadership development and Executive Diversity and Inclusion Ultimately, Gittens will manage more organizational culture from Certificate Program. than 60 employees. 34 VOLUME 19 • NUMBER 1 Interview by Andrew Hellpap Why did you choose to work in social media. The second priority is for the academic administration rather than SMPH to more actively build partnerships Equity and inclusion are significant the private sector? with institutions that graduate diverse parts of your role. What makes these The sense of mission, creativity and students and to create opportunities for issues so important to the school? development attracted me to academic diverse students to visit campus and see us Diversity and inclusion are critical to administration. As a lifelong learner, it’s a as a viable option for their education. a school of medicine and public health. natural fit to be part of the academy and Nationally, what’s being done to Diversity is linked to creative problem solving support learners, faculty and staff. increase minority student enrollment? and innovation, which are key in clinical care What drew you to the SMPH? Building relationships with programs that and research. Also, diversity among providers I relish the opportunity to be part of this graduate high numbers of diverse students leads to better quality outcomes, especially great university and grow my career. My is key to creating long-term pathways. We for diverse patient populations—mitigating role represents the next step toward my also must make sure these students have the impacts of health care disparities for our goals and the chance to integrate diversity the infrastructure and support to thrive here. most vulnerable patients. I believe a diverse, and inclusion values into human resources Nationally, the trend is toward conducting inclusive workforce helps boost employee practices at our school. outreach, developing pre-matriculation engagement and productivity overall. What do you like most about programs and ensuring financial support. Please describe the school’s Wisconsin, and why? What other elements of diversity do team effort surrounding equity Wisconsin is naturally beautiful. I grew you focus on? and inclusion. up in Maryland, off the Chesapeake Bay, While Dr. Tracy Downs, director of the The SMPH is building the infrastructure to so being near the lakes is appealing. I am SMPH’s Office of Multicultural Affairs, implement a Diversity and Inclusion Strategic adapting to Wisconsin’s cold weather. primarily focuses on student diversity and Plan. This year, we will focus on branding A friend from Michigan once told me you retention, I focus on workforce development, and communicating about all the great work never really get used to the cold—you just communication, and overall processes being done throughout the school. We’re get used to cold. Aside from that, the that promote diversity and inclusion. This continuing to enhance strong programs like being great people in Madison and at the university includes working with faculty and staff who the Centennial Scholars to recruit and retain have embraced my wife, Cheryl, our two sons have traditionally been under-represented diverse faculty, as well as various student and me. We feel very welcome here. in academic medicine. In addition, I am pathway programs. concerned with equity in regard to salary, I also am helping to design development You are a 13-year Marine Corps promotional opportunities and career programs related to unconscious bias veteran. Did you see combat, and how development. and strategies to promote equity and does your service impact your life? inclusion. With support from Dean Robert I did not see combat directly, but I served When we experience racially tense Golden, school leaders will participate in an in an infantry unit during both Gulf Wars. situations in our city, state or nation, interactive unconscious bias workshop. Such My military service provided a great what steps do you recommend to sessions are designed to facilitate a shift in foundation for how I approach challenges— keep communication open? consciousness with regard to inclusion and with tenacity and perseverance—even in the First, there is no silver bullet or canned organizational decision-making. face of adversity. It also has given me the response for these situations. We have to ability to maintain perspective. I realize where create spaces to listen to the concerns, How do you juggle all the roles administrative crises fall on the spectrum of pain and fear of those affected. It also is with which you are tasked? real-life crises, so I am able to deal with them an opportunity for leaders to step up and My passion for what I do makes the with a level of calmness that characterizes reaffirm their commitment to an inclusive juggling somewhat easier, but I am cognizant my leadership. culture by word and deed. that it takes a terrific team to accomplish anything great within an organization. I focus What is the SMPH’s greatest You see students and faculty every on developing, coaching and mentoring those challenge in regard to recruiting more day. What interesting fact would you around me. Another benefit of my role is the minority students? like them to know about you? opportunity to integrate the tenets of equity I believe the challenge is two-fold. The I often joke that my work in diversity and and inclusion in human resources practice. first priority is to continue focusing on inclusion started while I was attending a improving the climate for diverse students. residential high school, Phillips Academy at Current students are our best advocates. Andover, Massachusetts. Anyone who wants Those who have a negative experience to know more about how I got started in based on bias can do irreparable harm to an this work can Google my name and Phillips institution’s reputation, especially through Academy at Andover.

QUARTERLY 35 RESEARCH ADVANCES

Increased Understanding of Immunologic Tolerance

pre-clinical study at the provide a path to understanding biomarkers of tolerance status lymphocytes responsible for University of Wisconsin how to induce such tolerance and as a vehicle for therapeutic that alloreactivity. A School of Medicine and and have implications for applications of tolerance.” This study is the first to Public Health (SMPH) suggests tumor immunity, organ The study sought to describe split tolerance as that immunological tolerance— transplantation, autoimmune understand the role of occurring on different surface in which the immune system diseases and reproduction. exosomes as a natural means areas of a cell. It has important does not respond to substances “The induction of tolerance of amplifying, in newborns, implications in cell biology and capable of producing an is a largely underachieved maternal-fetal peripheral molecular immunology. immune response—may result goal in transplantation and tolerance that lasts into Jon J. Van Rood, MD, from interactions between autoimmunity fields,” says adulthood. Findings show that PhD, of the Leiden University dendritic cells and extracellular Will Burlingham, PhD, the the presence of a small number Medical Center, the vesicles, or exosomes. principal investigator (PI) and of a mother’s cells in her Netherlands, was the co-PI, Published in the a professor in the Division of offspring generated a “split” and other researchers from the Proceedings of the National Transplantation in the SMPH tolerance that stimulated SMPH and William S. Middleton Academy of Sciences, the Department of Medicine. “Our classical alloreactivity while Memorial Veterans Hospital, mouse study is a long way research holds the promise silencing cells that help Leiden University and the from being replicated in of opening an avenue for antibody-forming and killer University of Pittsburgh Medical humans. However, findings research using exosomes as Center were involved.

New Cellular Pathway of Cancer Therapy Resistance

esearch in the University telling the cell to survive, we could enhance the efficacy of Wisconsin School of divide and spread. Thought to of antibody-based therapies.” RMedicine and Public function on the cell’s surface, Findings from the current Health’s Department of Human RTKs recently have been found study identified a new RTK, Oncology could lead to better inside the nucleus. called AXL, that promotes the outcomes for patients with “Nuclear localized RTKs translocation of RTKs from the head and neck, lung and can mediate resistance to cell membrane to the nucleus. triple-negative breast cancer, cancer therapies by providing This increased trafficking of particularly those resistant to an alternative signaling RTKs from the membrane to common therapies. Published pathway within the nucleus,” the nucleus ultimately leads to in Science Signaling, the study says Toni Brand, PhD, the lead therapeutic resistance. enhances understanding of author and a former graduate The study provides a signals that regulate a growth student in the lab of Deric rationale for therapeutically Left to right: Mari Iida, PhD, Deric Wheeler, PhD, and Toni Brand, PhD, conduct research in pathway in many tumor types. Wheeler, PhD ’04, associate targeting AXL to block Wheeler’s lab. Receptor tyrosine kinase professor, Department of movement of RTKs to (RTK) proteins are best studied Human Oncology. “We wanted the nucleus and thus for how they receive signals to identify how to block RTKs’ reversing drug resistance in from outside the cell and movement into the nucleus so these cancers. transmit that signal internally,

36 VOLUME 19 • NUMBER 1 Finding Re-Writes Anatomy Texts

eurosurgeon Amgad away from the upper trunk failed. He re-operated, grafting Hanna, MD, knew nerve. More importantly, they the nerves in the order he has Nthat what he saw in will improve care for trauma shown to be correct, and the the operating room did not patients who suffer injuries that patient regained use of his arm. match diagrams in anatomy leave them in pain and unable The difference is the order textbooks, so he tested his to fully use their arms. of the branching of three hunch in the University of An associate professor nerves: the suprascapular Wisconsin School of Medicine in the SMPH Department of nerve (S); the posterior division and Public Health’s (SMPH) Neurosurgery, Hanna is a (P); and the anterior division anatomy laboratory. Dissections national expert in repairing (A). Anatomy illustrations confirmed his observations brachial plexus injuries. If traditionally showed the order and proved nearly 500 years of caught early, damage can be as SAP, but Hanna’s research anatomy texts wrong. repaired surgically, but the shows the correct order is SPA. the anatomy books on Hanna’s Hanna’s findings, published surgeon must have a correct This misunderstanding shelf have the incorrect in the Journal of Neurosurgery, understanding of anatomy. goes back to the Middle Ages, order. But Hanna says other will rewrite how anatomy books Early in his career, he when Andreas Vesalius wrote neurosurgeons who specialize depict the brachial plexus, repaired the brachial plexus De Humani Corporis Fabrica. in the peripheral nervous where the nerves controlling of a patient to match the text The mistake was carried system have noted that reality the shoulders and arms branch illustrations, and the surgery through modern times; most of does not match the books.

Consciousness During Surgery Lower than Estimates

n international study of earlier studies, using a similar at consciousness in routine 260 surgical patients technique, as reporting clinical practice. Although A found that, contrary to awareness of a stimulus while we view such consciousness many previous studies, just under general anesthesia. during surgery as important, more than 4 percent were Published in Anesthesiology, we urge caution in interpreting conscious of the external world the new research—conducted the results. We looked at a while under general anesthesia at six sites around the very brief ‘snapshot’ of the but before the start of world—was led by Robert time patients spend under surgery. None who responded Sanders, MBBS, PhD, assistant anesthesia. Also, these remembered it afterward. professor, Department of patients likely had very to drift patients to sleep may Researchers noted that Anesthesiology, University of different experiences from not always be effective in there are no known long-term Wisconsin School of Medicine those who report being awake preventing patients from problems associated with and Public Health. but unable to move or speak regaining consciousness the brief period of awareness “This was the first during surgery.” following intubation. Sanders’ captured in this study, and multi-institution collaboration Ultimately, Sanders says, future research will look at stressed this should not investigating the use the goal is to meet patients’ variables that might result in dissuade patients from having of the isolated forearm expectations to be unaware of patients becoming conscious surgery to improve their health. technique,” says Sanders. surgery or any external stimuli and ways to prevent it. Fortunately, this is far “The anesthetic technique during general anesthesia. lower than the approximately was left to anesthesiologists’ Findings suggest that a 37 percent identified in discretion. We wanted to look single IV injection of anesthetic

QUARTERLY 37 RESEARCH ADVANCES

Your Brain While Driving: Split Activity Allows You to Listen and Drive

voice or the radio show activated the brain networks known to serve listening, while the act of driving activated the distinct ‘driving’ network. However, the relationship between the driving and listening networks looked completely different: during the integrated GPS-listening task, the two networks were integrated and actively exchanging signals with one another. In contrast, during driving while listening to the radio show, the integration of information decreased to zero. Remarkably, these two networks were more integrated when subjects were doing absolutely nothing than they were during task performance. “An intriguing question is what happens any of us have had the experience Sleep and Consciousness and a professor to consciousness when driving while of pulling into the driveway, with in the SMPH Department of Psychiatry. listening in the split condition,” Tononi no clear memory of the drive. “This temporary split may resemble, to M notes. “Is there a single conscious stream, Now a team of University of Wisconsin some extent, what happens after epilepsy with attention deployed primarily to a School of Medicine and Public Health patients have surgery to disconnect the dominant task, typically listening, and (SMPH) consciousness researchers has two hemispheres to relieve seizures. much less to driving? Or does driving used brain imaging to show how the brain The surgically disconnected brain is become unconscious, as on autopilot? allows you to drive a familiar path while able to manage two separate streams of Or, does a normally integrated conscious concentrating on a radio show: It literally consciousness, one per hemisphere.” stream split into two separate conscious splits the tasks in half, with one part of the The findings are being published in streams that coexist within the same brain, brain navigating the drive while the other the Proceedings of the National Academy as indicated by studies of patients with an part concentrates on the broadcast. of Sciences. anatomically split brain?” Even more intriguing, the two circuits The researchers put 13 healthy male The study’s lead author is Shuntaro operate independently of one another, volunteers in a driving simulator while their Sasai, PhD, a research associate of showing no integration with the task of the brains were being imaged via functional the SMPH. Other members of the team other circuit. magnetic resonance imaging (fMRI). include Melanie Boly, MD, PhD, a resident “It seems, at times, that the healthy In one condition, the group had to in the SMPH Department of Neurology, brain can function wholly split into two perform the ‘integrated task’ of listening and Armand Mensen, PhD, of the SMPH parts,” says to a GPS-controlled voice giving complex Department of Psychiatry. lead researcher directions to a simulated destination Giulio Tononi, while driving. In the other condition, they MD, PhD performed the ‘split-task’ of listening (photo at right), to an engaging radio talk show, entirely director of unrelated to the act of driving. the Wisconsin As anticipated, and consistent with Center for previous research, listening to the GPS

38 VOLUME 19 • NUMBER 1 SPORE GRANT Continued from page 6

provide critically important tumor (PhD) (both professors in the biology advances to be able to leadership, and to the entire specimens to the SPORE teams Department of Surgery), who significantly impact cure rates,’’ team of all-star scientists, who for research studies. direct the Career Enhancement Harari says. will move this work from the “I have worked very closely and Developmental Research “That is what the SPORE molecule to the patient as they with Greg Hartig for 23 years. Programs within the grant is all about. We are finally develop treatments.” He is a remarkably talented HNC SPORE grant.” unleashing 25 years of molecular Harari believes the UWCCC surgeon who brings a terrific Harari believes that while biology research to better fight has the talent to put together bedside manner and great technical advances in radiation individual cancers.” other successful SPORE compassion to cancer patients,” and surgical treatments SMPH Dean Robert Golden, proposals related to several says Harari. have improved outcomes for MD, shares Harari’s enthusiasm. major cancer types. He hopes to “Since Tim McCulloch’s HNC patients to date, major “This exciting new SPORE share what the head and neck arrival at UW Health 10 years additional gains will come from grant highlights the unique cancer team has learned to help ago, the HNC program has new findings in UW-Madison strengths of the SMPH, other colleagues reach that bar. further expanded, including molecular biology laboratories. where science that bridges “A SPORE grant offers a the hiring of talented new They star in three of the four multiple departments and fantastic opportunity to positively surgeons and radiation SPORE projects at the UWCCC. scientific disciplines moves impact the next generation oncologists. We also have “We are so much better at basic molecular discovery into of cancer researchers so exceptional leadership from treating these cancers in 2017 meaningful clinical advances,” their work can truly benefit research experts Nadine Connor than we were in 2003, but we says Golden. “We are grateful to cancer patients.” (PhD) and Susan Thibeault have been waiting for molecular Paul Harari for his remarkable

INTERPROFESSIONAL HEALTH EDUCATION Continued from page 14

team-based care as one of 10 “threads” have posed challenges in the past, but they deal with patient and animal care, Roberts deemed so vital that it’s woven into teaching expressed optimism that the new center will and the CIPE Advisory Council envision throughout all four years of medical school. find ways for students to learn together. expanding throughout UW-Madison to Robert Holland, MD, thread director “It’s not just about teaching students include 20 or more undergraduate and for quality, safety and interprofessional what a pharmacist does or what a physician graduate programs. From engineering to health education, shares that the ForWard assistant does,” Rusch shares. “It’s about law, there’s a wealth of knowledge and Curriculum emphasizes interprofessional how we can help change the culture so all interest that can enrich the interprofessional education to help graduates maximize the health care professionals work together, experience, according to Roberts. diverse backgrounds of health professionals collaboratively, to improve patient outcomes. “The center has the potential to facilitate to provide better, safer team-based care. We hope the emphasis of interprofessional the transformation of education,” Zorek “In the past, we’ve always had health education in the ForWard curriculum notes. “We can play an instrumental role by experiential learning within health care will help move us in that direction.” getting students out of the ‘silos’ of individual teams, so a lot of what students learned She adds, “Our challenge is to identify programs and into the same spaces to learn about interprofessional concepts was through or create quality assessments to measure about, from and with each other.” an implicit or informal curriculum,” Holland student competencies in interprofessional Holland says there are no boundaries for says. “Now, starting with their first block health and team-based care. Dr. Holland and what programs could be included because of learning, medical students are explicitly I are considering looking at businesses—not many would add value to the center. exposed to these concepts.” just thinking of health care professions, but “I would never look at another profession Another of CIPE’s major goals is to help how people work together in other industries and say, ‘I don’t think we can benefit from various professional programs coordinate and how they measure good teamwork.” collaboration,’” Holland comments. “I think shared student experiences. The Center’s Future everyone has something to add, and we can Holland and SMPH Clerkship Curriculum While CIPE is debuting with involvement celebrate the diversity of backgrounds as we Manager Roberta Rusch, MPH, note that from core health professions schools that work to improve patient care.” the varying degree levels of the programs

QUARTERLY 39 PERSPECTIVES

The UW Initiative to End Alzheimer’s Disease FORGING PATHWAYS TO DISCOVERY, IMPROVED CARE AND SERVICE

lzheimer’s disease is the most Alzheimer’s disease, special brain scans common form of dementia, projected and examination of the cerebrospinal fluid A to afflict nearly 14 million Americans show evidence of disease pathology at a by 2050 and costing the nation more than stage when the person has no symptoms. $1 trillion, unless discoveries are made These findings are important as they will to treat, prevent and cure the disease. help identify people at increased risk for Alzheimer’s is the sixth leading cause of Alzheimer’s and offer them treatments that death in the United States and is the only could either slow or stop their progression disease among the top 10 causes of death in toward developing symptoms. America that cannot be slowed or prevented. Besides biomedical research, another Thus, in January 2011, President Obama distinguishing strength of the ADRC and signed the National Alzheimer’s Project Act WAI is their collaborative goal to identify into law, requiring creation of a national health disparities and achieve health strategic plan to address the impending equity through statewide community Alzheimer’s tsunami and find a cure by 2025. outreach and engagement. Focused Founded in 2016, the University of currently on the state’s African American Wisconsin Initiative to End Alzheimer’s and Native American populations, ADRC features internationally renowned programs and WAI scientists have received new Wisconsin Idea, the ADRC and WAI work and collaborations between the Wisconsin federal funds to study preclinical biomarkers together across the state, seeking new Alzheimer’s Disease Research Center (ADRC) of Alzheimer’s disease in African Americans. understanding and improved treatments for and the Wisconsin Alzheimer’s Institute (WAI) Study results will provide novel insights Alzheimer’s through research and community within the UW School of Medicine and Public into the onset of Alzheimer’s pathology in engagement to benefit the people of Health (SMPH). The initiative’s physicians, African Americans. Also, the WAI Regional Wisconsin and beyond. scientists and staff focus on the many Milwaukee Office provides innovative clinical We look forward to partnering with you to dimensions of Alzheimer’s disease through and community programs to serve older create a future free from Alzheimer’s disease! research to understand, treat and prevent adults with Alzheimer’s and their families the disease, and through novel clinical and from communities of color. Sanjay Asthana, MD public health approaches to improve care Additional distinctive features of the Associate dean for of patients and their families and improve ADRC and WAI include their complementary gerontology, SMPH, health equity across diverse populations. expertise in models of care, with the ADRC and director, Wisconsin The ADRC and WAI employ conducting research on post-hospital care Alzheimer’s Disease complementary approaches to accomplish for people with dementia, and the WAI Research Center the nation’s and UW Initiative’s mission to facilitating a statewide network of innovative end Alzheimer’s disease. With that goal, Dementia Diagnostic Clinics. The initiative’s Jane Mahoney, MD the initiative supports biomedical research, public health mission is accomplished by the (PG ’89) primary prevention studies, improved models WAI, which facilitates the dissemination and Director, Wisconsin of care and community-based programs implementation of best-practices to benefit Alzheimer’s Institute to improve public health and health equity. all Wisconsin communities. Finally, both the Research sponsored by these programs has ADRC and WAI work collaboratively to train led to the publication of multiple seminal the next generation of scientists, clinicians findings that are leading important aspects and educators. Cynthia Carlsson, MD, of Alzheimer’s research. For the first time, The initiative’s faculty, support staff, MS ’05 findings from the ADRC and WAI underscore administrators and UW Foundation Associate director, the significance of a parental history of development team are committed Wisconsin Alzheimer’s Alzheimer’s as an important risk factor for the to excellence and the successful Institute disease. These findings suggest that, among accomplishment of the UW Initiative to a subset of people with a family history of End Alzheimer’s. True to the tenets of the

40 VOLUME 19 • NUMBER 1 i know you

... OR DO I? If you think you can identify the person in the photograph at right, send your guess to [email protected]. We’ll draw one of the correct responses and announce the winner in the next issue of Quarterly.

For the last issue (see below), Pamela A. Wilson, MD, won the prize drawing and HINT: This Nebraska native and military veteran will receive a gift from the Wisconsin played a role in automating certain processes. Medical Alumni Association!

In the past issue of Quarterly, 40 people correctly guessed Several people the identity of Jeffrey Grossman, MD (PG ’78, ’82). Throughout commented on his four-decade career at the University of Wisconsin-Madison, Grossman’s wild Grossman held many leadership posts, including chair of the hair, including David UW School of Medicine and Public Health’s Department of Cohn, MD (PG ’78), Medicine and the school’s senior associate dean for clinical who said, “As the affairs; vice president of UW Hospital and Clinics; president two docs with the and CEO of the UW Medical Foundation; and first CEO of the best Afros in our integrated UW Health. (residency) class, we A State University of New York (SUNY) medical school became fast friends!” classmate of Grossman, William M. Nauseef, MD (PG ’79), Elizabeth called him “one of the gaggle of SUNY Upstate folks who came Silverman, MD, to UW-Madison in the mid-1970s.” commented, Grossman’s medical school roommate, Samuel N. Pearl, MD “Jeff Grossman is (PG ’82), was a plastic surgery resident when Grossman also a wonderful pulmonologist and administrator who cares so was a post-graduate trainee at UW Hospital and Clinics. Pearl much about his patients, colleagues, residents and students. He and several other responders congratulated Grossman on his always wears his heart on his sleeve!” recent Belzer Award and retirement. Michael DeVita, MD ’11, shared similar sentiments Robert Factor, MD (PG ’83), said Grossman looked and stated, “He taught me a great deal in medical school. “just the way he did in spring 1980 when I first met him as I remain appreciative of Dr. Grossman’s impact on my a PG1 resident in the UW Hospital emergency room,” where medical education.” Grossman was a fellow who supervised Factor. We Want to University of Wisconsin Medical Alumni Association Nonprofit Org. Health Sciences Learning Center U.S. Postage Hear From You 750 Highland Ave. PAID Madison, WI 53705 Madison, WI Please send us information about your honors, Permit No. 2117 appointments, career advancements, publications, volunteer work and other activities of interest. We’ll include your news in the Alumni Notebook section of the Quarterly as space allows. Please include names, dates and locations. Photographs are encouraged. Have you moved? Please send us your new address.

CONTACT INFORMATION: Wisconsin Medical Alumni Association Health Sciences Learning Center 750 Highland Ave. Madison, WI 53705 OR online at med.wisc.edu/874 OR e-mail [email protected] MS-47554-17

PROJECT 72 University of Wisconsin-Madison’s “Wisconsin Idea”—that the university’s influence should benefit citizens in every corner of the state—is shining brightly through the Project 72 statewide outreach initiative. It highlights partnerships between UW-Madison and its alumni in each of the state’s 72 counties. Several UW School of Medicine and Public Health alumni—a few of whom are listed below—shared their stories on the Project 72 web site: allwaysforward.org/wi/all-counties/

• Jackie Arbuckle, MD ’95 • Michelle Reisen- • Joel Miller, MD (PG ’92) Garvey, PA ’00 • John Drawbert, MD ’80 • Anne Schierl, MD ’57 • Meg Dallapiazza, PA ’80 • Deb O’Connell, PT ’75

Anne Schierl, MD ’57 (photo at left), from Wisconsin’s Portage County, shared her “Civic-Minded Success Story” through Project 72. A member of the Wisconsin Medical Alumni Association Advisory Board, Schierl is active in alumni events and spreads her Badger Pride wherever she goes.