Poliomyelitis in the Lone Star State
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A Guide to Preparing Multiple Choice Items
A Guide to Preparing Multiple Choice Items Introduction The most commonly used type of test item in admissions, certification, and licensure examinations is the multiple choice item. The purpose of this guide is to assist test developers and representatives of professional associations in becoming more skilled in writing multiple choice test items. Preparing multiple choice items may appear on the surface to be a relatively simple task, given familiarity with the subject matter. However, experienced test authors find that this task actually requires a great deal of skill, patience, and creativity. In the sections that follow, general knowledge is used as the content of the examples, in order to facilitate understanding of the principles by professionals from diverse content areas. The skills needed for writing quality items are similar regardless of content discipline. Like any other skill, multiple choice item writing requires a significant amount of painstaking practice with appropriate feedback. It is essential that you try out your multiple choice items on others. This process will help you to uncover ambiguities in wording and unintended violations of item writing principles. Feedback from others will greatly enhance your item writing quality and productivity. Parts of the Multiple Choice Item All multiple choice items consist of two basic parts: the stem and the responses. The stem is the introductory statement or question that elicits the correct answer. The responses are suggested answers which complete the statement or answer the question asked in the stem, only one of which is the correct answer. In the examples that follow, four responses (i.e., 1 correct response and 3 incorrect responses) are presented. -
Jonas Salk at the National Press Club, April 12, 1965
Jonas Salk at the National Press Club, April 12, 1965 Jonas Salk, May 1962. A.F.P. – D.P.A. Photos. National Press Club Archives On the tenth anniversary of the licensing of the polio vaccine he developed, Dr. Jonas E. Salk (1914-1995) visited Washington to accept a joint congressional resolution that hailed the vaccine as “one of the most significant medical achievements of our time.” At the White House, President Johnson offered Salk his congratulations. The day also marked the twentieth anniversary of the death of former President Franklin D. Roosevelt, who, having suffered from paralytic polio since 1921, had established the foundation that funded Salk’s efforts. Following his meetings with Congress and the President, Salk gave a talk and answered reporters’ questions at a National Press Club luncheon. In the title of its lead editorial ten years earlier celebrating the successful testing of the new vaccine, the New York Times proclaimed the “Dawn of a New Medical Day.” Testing of the vaccine, like the funding for its development, had engaged the participation of millions of ordinary American citizens. Through March of Dimes campaigns, hundreds of thousands of volunteers went door-to-door raising $41 million in 1952 alone from average donations of 27 cents. The tests involved 1.8 million school children, 200,000 volunteers, 64,000 teachers, and 60,000 physicians, nurses, and health officials, making it the largest clinical trial in history. Interpreting the jubilant 1 reaction to news that the vaccine had been proven safe and effective, the Times commented, “Gone are the old helplessness, the fear of an invisible enemy, the frustration of physicians.” Poliomyelitis, also known as infantile paralysis, is an extremely contagious viral infection caused by any of three types of poliovirus. -
Dr Sabin's Legacy to the World Jaime Sepulveda
World Health • 46th Year, No . 3, Moy-June 1993 IS Dr Sabin's legacy to the world Jaime Sepulveda oliomyelitis has been eradicated Poliomyelitis acquired epidemic from the Americas and other proportions in the Americas at the end Pareas, and is expected to be of the last century, mainly in the most eliminated from the world by 1995. developed regions. In Mexico, the first This outstanding achievement has epidemic outbreaks started in the been made possible thanks to the 1940s and caused many victims. The availability of an excellent vaccine oral poliovaccine was made available coupled with successful vaccination in Mexico in the early 1960s. programmes. Few actions in public Coverage was low then, and mainly health have become so deservedly concentrated among well-to-do prestigious as the vaccination children. In the 1970s, a new national campatgns. programme reached much greater The first major achievement of the numbers of children and poliomyelitis immunization effort was the cases began to drop. eradication from the world of However, it was not until1985 that smallpox in the late 1970s. But the a new polio immunization initiative success with smallpox is only the took place, with the goal of reaching all children, regardless of social status Or Albert Bruce Sobin, who perfected the first most visible component of all the viable live vaccine against polio. many benefits conferred by or geographic location. This new immunization programmes strategy, focusing on "National worldwide. Not only have they Vaccination Days", was originally brought about the survival of children proposed by Professor Albert Sabin, who would otherwise have died; they the US scientist who developed the have greatly enhanced the quality of oral poliomyelitis vaccine. -
Vaccine Symposium Louis Pasteur As Pioneers Who Fundamentally Changed the Nature of Presented by the MSU Department of Microbiology & Immunology Human Health
Maurice Hilleman, 1919-2005, was a 1941 MSU graduate who saved the lives of millions by developing a wide array of vaccines. nd 2 Maurice Hilleman A Miles City native, Hilleman graduated atop his class at what was then Montana State College with dual degrees in chemistry and microbiology. His name often accompanies those of Jonas Salk and Vaccine Symposium Louis Pasteur as pioneers who fundamentally changed the nature of Presented by the MSU Department of Microbiology & Immunology human health. The abstract on a National Institutes of Health obituary for Hilleman describes him this way: "Microbe hunter, pioneering virologist, and the world's leading vaccinologist." Mi Among Hilleman's scientific achievements: • A hepatitis B vaccine that was the first vaccine to prevent a cancer in humans (liver cancer, or hepatoma). • A measles-mumps-and-rubella combination vaccine chat marked the first time vaccines for different viruses were successfully combined in a single shot. • Vaccines for meningitis and pneumonia. • A mumps vaccine that came after Hilleman isolated the virus by swabbing the back of his daughter Jeryl Lynn's throat when she was stricken with the disease (50 years later it is still the basis for most mumps vaccines). • A more complete understanding of the ways different strains of the flu change slightly from year to year, which led to the practice of developing an annual seasonal flu vaccine. • The first successful prediction of a coming influenza pandemic and development of a vaccine that thwarted it, 2018 possibly saving close to a million people in 1957. Indeed, Hilleman was responsible for developing 8 out of the 14 recommended vaccinations today. -
Re-Thinking Pandemics: State, Society, and Disease in British History, 1830-1960
Providence College DigitalCommons@Providence History & Classics Undergraduate Theses History & Classics Spring 2021 Re-thinking Pandemics: State, Society, and Disease in British History, 1830-1960 Meghan Walsh Follow this and additional works at: https://digitalcommons.providence.edu/history_undergrad_theses Part of the European History Commons, and the History of Science, Technology, and Medicine Commons Re-thinking Pandemics: State, Society, and Disease in British History, 1830-1960 by Meghan Walsh HIS 490 History Honors Thesis Department of History and Classics Providence College Spring 2021 This thesis is dedicated to the 3 million people who lost their lives to COVID-19 and to all the frontline workers and essential employees, without whom nothing would be possible. “Epidemics all follow this similar arc where people deny or dismiss the threat until it becomes impossible to ignore any more,” - Mark Honigsbaum, medical historian at City, University of London CONTENTS ACKNOWLEDGEMENTS………………………………………………………………………vi INTRODUCTION …………………………………………...……………………………………1 CHAPTER 1: THE STORY OF CHOLERA ……………………………………………………..8 CHAPTER 2: IGNORING INFLUENZA………………………………………………………..23 CHAPTER 3: TREATING POLIO ……………………………………………………………...36 CONCLUSION: HOW THINGS HAVE CHANGED…………………………………………...54 BIBLIOGRAPHY.........………………………………………………………………………….59 v ACKNOWLEDGEMENTS A project this size truly takes a village, and I am eternally grateful to mine for seeing me through to the end of this. Researching and immersing myself in the lives and experiences of British citizens from three major pandemics, whilst living in one, was an interesting journey, but several people ensured I never went on it alone. To Dr. Smith and Dr. Murphy, thank you for making this possible and for granting me the opportunity to write a senior thesis. Your comments, guidance and encouragement were invaluable. -
Renato Dulbecco
BIOLOGIE ET HISTOIRE Renato Dulbecco Renato Dulbecco : de la virologie à la cancérologie F.N.R. RENAUD 1 résumé Né en Italie, Renato Dulbecco fait de brillantes études médicales mais est plus intéressé par la recherche en biologie que par la pratique médicale. Accueilli par Giuseppe Levi, il apprend l’histologie et la culture cellulaire avant de rejoindre le laboratoire de S.E. Luria puis celui de M. Delbrück pour travailler sur les systèmes bactéries-bactériophages puis sur la relation cellules-virus. Il met au point la méthode des plages de lyse virales sur des cultures cellulaires. Il est aussi à l’origine de la virologie tumorale moléculaire. D. Baltimore, HM Temin et lui-même sont récompensés par le prix Nobel de médecine et physiologie en 1975 pour leurs travaux sur l'interaction entre les virus tumoraux et le matériel génétique du matériel cellulaire. Très tourné vers les aspects pratiques et expérimentaux de la recherche, il est resté le plus long - temps possible à la paillasse et a initié un très grand nombre de jeunes chercheurs. mots-clés : culture cellulaire, virologie tumorale, plages de lyse, bactériophages. I. - LA JEUNESSE DE RENATO DULBECCO C'est à Catanzaro, capitale régionale de la Calabre en Italie, que naît Renato Dulbecco le 22 février 1914. Sa mère est Calabraise et son père Ligurien. Il ne reste que très peu de temps dans le sud de l’Italie, car son père est mobilisé et sa famille doit déménager dans le nord à Cuneo, puis à Turin. À la fin de la guerre, la famille Dulbeco s'ins - talle à Imperia en Ligurie. -
The March of Dimes and Polio: Lessons in Vaccine Advocacy for Health Educators
Feature Article The March of Dimes and Polio: Lessons in Vaccine Advocacy for Health Educators Dawn Larsen ABSTRACT The polio vaccine became available in 1955, due almost entirely to the efforts of the March of Dimes. In 1921, Franklin Roosevelt gave a public face to polio and mounted a campaign to prevent it, establishing the National Foundation for Infantile Paralysis in 1938. During the Depression, U.S. citizens were asked to contribute one dime. Entertainer Eddie Cantor suggested the name the March of Dimes, paraphrasing the popular newsreel “The March of Time.” Jonas Salk advocated a killed-virus vaccine while Albert Sabin proposed a live-virus vaccine. Both competed for both recognition and funding from the March of Dimes. In 1955 Salk’s vaccine was adopted, nationwide vaccination programs were implemented, and polio rates dropped by 80 percent. In 1961, Sabin’s vaccine, endorsed by the American Medical Association, became the vaccine of choice. The World Health Assembly advocated polio eradication by the year 2000. By 2004 eradication efforts were threatened by allegations linking vaccines to chronic diseases. Immunization dropped and polio resurfaced in the U.S., Australia, Africa and Russia. Research linking vaccines to chronic disease was dis- credited, but vaccine opponents remain active. Health educators are well positioned to mitigate damage caused by the anti-vaccine movement and address barriers to immunization efforts. Larsen D. The March of Dimes and polio: lessons in vaccine advocacy for health educators. Am J Health Educ. 2012;43(1):47-54. Submitted May 30, 2011. Accepted July 9, 2011. In 2008, The March of Dimes cel- prenatal health promotion programs, and of the virus that has been ranked second ebrated its 70th anniversary. -
INFLUENZA VIRUS VACCINE THREE YEARS EXPERIENCE in the U. 8. ARMY by LT. COL. T. G. FAISON Ojke of the Surgeon General, Washingto
INFLUENZA VIRUS VACCINE THREE YEARS EXPERIENCE IN THE U. 8. ARMY By LT. COL.T. G. FAISON Ojke of the Surgeon General, Washington, D. C. It is a pleasure and privilege to be able to meet with the United States- Mexico Border Public Health Association. Rapid transportation has increased the need for cooperative action in the field of national and international health. The vectors and agents of disease do not respect international boundaries or treaties. 1 have always been impressed by the amicable international relation- ship between doctors, other scientific men and especially public health personnel. The results of this friendly and cooperative attitude have been most beneficial to mankmd. For the three year period 1945 to 1948, the U. S. Army required the inoculation of al1 troops with influenza virus vaccine. The vaccine con- tained 50% Type B (Lee), 25% Type A PR8, and 25% A Prime (Weiss or FMl) strains. The decision to vaccinate was based largely upon the signifkant results obtained in evaluation studies of influenza virus vaccine during 1943 and 1945** 2, 3. Since 1945, evaluation studies con- ducted by the Commission on Influenza of the Army Epidemiological Board and other investigators have not been in satisfactory agreement as to results which would determine the advisability of its use4* 6* 6* l. In 1946-1947 and again in 1947-1948, reports show that the influenza vaccine which was given afforded no protection against the type of in- l Francis, Thomas; Jonas Salk; and William M. Brace: The Protective Effect of Vaccination Against Epidemic Influenza B, Jour. -
Book of Essays by Young Scie
Lasker Foundation and Diamonstein-Spielvogel Foundation Publish Book of Essays by Young Scientists Young scientists share personal stories of the legendary biomedical researchers and mentors who inspired their careers (New York City – November 10, 2020) – The Lasker Foundation and the Diamonstein- Spielvogel Foundation today announced the publication of “Inspiration: Young Scientists Reflect” edited by author, and advocate, Barbaralee Diamonstein-Spielvogel. The publication also honors the 75th Anniversary of the Albert and Mary Lasker Foundation, and the 25th Anniversary of the PEN America/Diamonstein-Spielvogel Art of the Essay Award. It includes a foreword, commissioned by the Diamonstein-Spielvogel Foundation, by author, journalist, and M.D., Rivka Galchen, who explores the history of the essay form and its early development by 16th century French humanist and philosopher Michel de Montaigne. It also contains a tribute to the PEN America/Diamonstein-Spielvogel Art of the Essay Award, by PEN America, the organization which stands at the intersection of literature and human rights to protect open expression in the United States and worldwide. The 11 essays in the booklet are the winning submissions to the 2020 Lasker Essay Contest, an annual global competition that engages young scientists and clinicians in discussion about the role of biomedical research in our society today. This year, students and young researchers were asked to describe how a notable scientist had inspired them – through the scientist’s personality, life experiences, and/or through their scientific contributions. The Lasker Foundation received over 300 submissions to the Contest. “These essays reflect the altruism of senior scientists as they guide younger men and women in the field and the power of mentorship in helping trainees define their endeavors in biomedical careers,” said Claire Pomeroy, president of the Lasker Foundation. -
Poliomyelitis and the Salk Vaccine
Poliomyelitis and the Salk Vaccine Table of Contents Preface......................................................................................................................................................................................................... 2 Center for the History of Medicine ......................................................................................................................................................... 2 Introduction ................................................................................................................................................................................................. 3 Collections .................................................................................................................................................................................................. 5 1 Return to Table of Contents Preface The Bentley Historical Library and the Historical Center for the Health Sciences (now the Center for the History of Medicine), with support from the Southeast Michigan Chapter of the March of Dimes Birth Defects Foundation, collaborated to commemorate the 40th anniversary of the announcement that the poliomyelitis vaccine developed by Dr. Jonas Salk was safe and effective. As part of the commemoration, a printed guide was prepared to highlight and illustrate the archival and manuscript holdings in the Bentley Historical Library relating to polio and the development and the testing of the Salk vaccine. In the period since the guide was published, -
Presidential Handwriting, 1/5/1977 (1)” of the Presidential Handwriting File at the Gerald R
The original documents are located in Box C54, folder “Presidential Handwriting, 1/5/1977 (1)” of the Presidential Handwriting File at the Gerald R. Ford Presidential Library. Copyright Notice The copyright law of the United States (Title 17, United States Code) governs the making of photocopies or other reproductions of copyrighted material. Gerald Ford donated to the United States of America his copyrights in all of his unpublished writings in National Archives collections. Works prepared by U.S. Government employees as part of their official duties are in the public domain. The copyrights to materials written by other individuals or organizations are presumed to remain with them. If you think any of the information displayed in the PDF is subject to a valid copyright claim, please contact the Gerald R. Ford Presidential Library. Digitized from Box C54 of The Presidential Handwriting File at the Gerald R. Ford Presidential Library THE WHITE HOUSE WASHINGTON , MEDAL OF FREEDOM CANDIDATES Art & Architecture v Alexander Calder* '~Georgia O'Keefe* Norman Rockwell Athletics v"Joe DiMaggio Business J. Willard Marriott, Sr. Scholarship & Education ~orman E. Borlaug vwill and Ariel Durant v Bruce Catton Science & Engineering v/John Bar de en* /James D. Watson Theology & Religion Spencer Kimball Communications Lowell Thomas* Vermont C. Royster Labor 'v I. w. Abel Law v Judge Henry Friendly Erwin N. Griswold Literature /Archibald MacLeish* '<James Michener* II National Security / \ .· Arleigh Burke Y/Omar Nelson Bradley * Wilber M. Brucker Performing Arts \_./Irving Berlin ~ing Crosby (Harry Lillis) v Arthur Fiedler* Mrs. Jouett Shouse Public Service George S. Aiken Mike Mansfield John Sherman Cooper Henry Cabot Lodge George Pratt Shultz* Medicine Rene Dubos Jonas Salk Albert Sabin *Denotes candidates who drew heavy support from within the White House staff . -
The 1954 Field Trial of the Salk Poliomyelitis Vaccine Paul Meier University of Chicago
TIIE BIGGEST PUBLIC IIEALTH EXPERIMENT EVER: The 1954 Field Trial of the Salk Poliomyelitis Vaccine Paul Meier University of Chicago [ Chapter 2 in Tanur JM et al. (Editors) Statistics: A Guide to the Unknown. Holden-Day San Francisco 1972 ] THE LARGEST and most expensive medical The determination to mount a major research experiment in history was carried out in 1954. effort to eradicate polio arose in no small part from Well over a million young children participated, the involvement of President Franklin D. and the immediate direct costs were over 5 million Roosevelt, who' was struck down by polio when a dollars. The experiment was carried out to assess successful young politician. His determination to the effectiveness, if any, of the Salk vaccine as a overcome his paralytic handicap and the protection against paralysis or death from commitment to the fight against polio made by poliomyelitis. The study was elaborate in many Basil O'Connor, his former law partner, enabled a respects, most prominently in the use of placebo great deal of attention, effort, and money to be controls (children who were inoculated with simple expended on the care and rehabilitation of polio salt solution) assigned at random (that is, by a victims and—in the end, more importantly—on carefully applied chance process that gave each research into the causes and prevention of the volunteer an equal probability of getting vaccine or disease. salt solution) and subjected to a double-blind evaluation (that is, an arrangement under which During the course of this research, it was neither the children nor the physicians who discovered that polio is caused by a virus and that evaluated their subsequent state of health knew three main virus types are involved.