US 2006025 1597A1 (19) United States (12) Patent Application Publication (10) Pub. No.: US 2006/0251597 A1 Yu et al. (43) Pub. Date: Nov. 9, 2006

(54) ANTI-ODOR COMPOSITIONS AND Publication Classification THERAPEUTIC USE (51) Int. Cl. (76) Inventors: Ruey J. Yu, Chalfont, PA (US); Eugene A6IL 9/00 (2006.01) J. Van Scott, Abington, PA (US) A61K 8/46 (2006.01) Correspondence Address: A6IR 8/49 (2006.01) HUNTON & WILLIAMS LLP 52) U.S. Cl...... 424/65: 424/76.2 INTELLECTUAL PROPERTY DEPARTMENT (52) s 1900 K STREET, N.W. SUTE 12OO WASHINGTON, DC 20OO6-1109 US 9 (US) (57) ABSTRACT (21) Appl. No.: 11/381,374 1-1. This application discloses a composition comprising a mal (22)22) FileFiled: Maway 3,5, 2006 odor compound and an anti-odor ingredient effective for Related U.S. Application Data reducing the presence or production of malodor. The com position may be topically applied to a subject and is useful (60) Provisional application No. 60/677,364, filed on May for cosmetic conditions, pharmaceutical indications, or other 4, 2005. objectives. US 2006/025 1597 A1 Nov. 9, 2006

ANT-ODOR COMPOSITIONS AND SUMMARY OF THE INVENTION THERAPEUTIC USE 0008. It is a feature of an embodiment of the invention to 0001. This application claims priority under 35 U.S.C. provide compositions comprising a sulfone and/or organic S119 to Provisional Patent Application No. 60/667,364 filed amine having an amino, imino, and/or guanido group that on May 4, 2005. can effectively prevent malodor produced by organic thiols or similar malodor compounds. It is a feature of an embodi FIELD OF THE INVENTION ment of the invention to provide a novel anhydrous com position comprising a thiol or similar malodor compounds 0002 This application relates to compositions compris that does not produce unpleasant malodor. We have found ing a malodor compound useful for cosmetic conditions, that whereas common solvents, such as water and ethanol, pharmaceutical indications, or other objectives. can enhance, but cannot suppress the malodor produced by a thiol or similar malodor compounds, certain other organic BACKGROUND OF THE INVENTION Solvents and ingredients may effectively prevent the mal 0003. Many cosmetic and pharmaceutical substances odor formation in an anhydrous composition. comprising molecules having a thiol, mercaptan, or a like group have an inherent, unpleasant malodor. The malodor is DETAILED DESCRIPTION OF PREFERRED objectionable to consumers when these Substances are used EMBODIMENTS as ingredients in topical compositions. It would thus be 0009 For the purposes of promoting an understanding of desirous to find a substance that can effectively prevent the the embodiments described herein, reference will be made to malodor formation or to formulate a novel composition that, preferred embodiments and specific language will be used to while containing a thiol or similar malodor compounds, does describe the same. The terminology used herein is for the not have the malodor. purpose of describing particular embodiments only, and is 0004 U.S. Pat. No. 5,733,535 entitled “Topical Compo not intended to limit the scope of the present invention. As sitions Containing N-Acetylcysteine and Odor Masking used throughout this disclosure, the singular forms “a,”“an.” Materials' disclosed compositions comprising certain per and “the include plural reference unless the context clearly fume chemicals to mask malodors associated with 0.01% to dictates otherwise. Thus, for example, a references to “a 50% N-acetylcysteine or related compounds. These perfume composition' includes a plurality of Such compositions, as chemicals are selected from the group consisting of aromatic well as a single composition, and a reference to “a topically esters, aliphatic esters, aromatic alcohols, aliphatic alcohols, active agent' or a "malodor compound is a reference to one aliphatic ketones, aromatic aldehydes, aliphatic aldehydes, or more agents and/or compounds, as well as equivalents aromatic ethers, and aliphatic ethers at a combined concen thereof known to those skilled in the art, and so forth. tration from 0.01% to 0.5%. The masking of N-acetylcys 0010 We have now discovered that sulfones, organic teine malodors by Such perfume chemicals, however, has amines (preferably heterocyclic amines), Solvents, and other been found to be incomplete or ineffective due to different ingredients can effectively prevent, counteract, or eliminate vapor pressure, different skin penetration rate, and a poor unpleasant malodor produced by malodor compounds. Sul binding affinity between N-acetylcysteine and the perfume fones and organic amines are particularly effective in reduc chemicals, especially when the composition is topically ing the malodor present or produced by an organic thiol or applied to human skin. similar malodor compounds in a composition containing 0005 U.S. Pat. No. 6,905,675 B2 describs the adjustment water or ethanol. For example, we have now discovered that of pH between 6.5 to pH 8.1 to control malodor of derma dimethylsulfone or methenamine can effectively prevent or tological compositions containing Sulfur compounds. The eliminate the malodor produced by compounds like N-ace malodor control by adjusting the pH of a composition, tylcysteine. Thus, the Sulfones or organic amines according however, is incomplete, unreliable, and ineffective, espe to embodiments may be used to prevent or inhibit, for cially when the composition is topically applied to the skin example, the malodor generated by a hair waving thiol or due to the acidic pH of the skin surface, similar malodor compounds, Such as thioglycolate. 0006 U.S. Pat. No. 4,388,301 describes the use of mont 0011. The unpleasant or malodor compounds referred to morillonite clays, such as bentonites, kaolin, hectorite, in this description preferrably include, but are not limited to, Smectite, Saponite, and attapulgite to control the malodor of organic mercaptains, thiol, and dithiol compounds and inorganic polysulfides. Such as calcium polysulfide. The derivatives thereof. As used herein, a thiol is a compound composition formed by use of the these montmorillonite that contains the functional group composed of a Sulfur atom clays is a paste composition that is messy when topically and a hydrogen atom ( -SH). This functional group is applied to the skin and fails to completely control the referred to either as a thiol group or a sulfhydryl group. malodor produced by compositions comprising polysulfides Thiols also may be referred to as mercaptains. Some specific examples of mercaptains, thiols, dithiols, and similar mal or a Sulfurated lime solution with pungent rotten egg odor. odor compounds include, but are not limited to, glyceryl 0007. The description herein of disadvantages and prob monomercaptan, thioglycolic acid, cysteine, cysteine esters, lems associated with known compositions, and methods is in N-acetyl-cysteine, N-acetyl-cysteine esters: N.S.-diacetyl no way intended to limit the scope of the embodiments cysteine esters, glutathione, glutathione esters, N-acetyl described in this document to their exclusion. Indeed, glutathione, N-acetyl-glutathione esters, methionine, ammo aspects of the invention may include certain features of the nium thioglycolate, calcium thioglycolate, Zinc described products, methods, and/or apparatus without Suf thioglycolate, potassiumm thioglycolate, monoethanolam fering from their described disadvantages. monium thioglycolate, mercaptopurine, lipoic acid, and 6.8- US 2006/025 1597 A1 Nov. 9, 2006 dimercaptooctanoic acid (dihydrolipoic acid). The malodors nylbis(2-methylphenol); 4,4'-sulfonyldiphenol, 2,2'- produced by these compounds range in degrees from rotten sulfonyldiethanol, and mixtures thereof. eggs, decomposed fish, dead animals, to Substances ejected 0017. The organic amines of preferred embodiments are by a skunk. odorless and have at least one amino, imino and/or guanido 0012. As an illustration, N-acetylcysteine is a potent group. More preferably, the organic amines are heterocyclic antioxidant, a precursor for biosynthesis of glutathione, and amines, which also may comprise other groups such as is therapeutically effective for topical prevention or treat NHOH, NHNH, NHCONH, NHC(=NH)NH CONH, ment of various cosmetic conditions and dermatological alkoxyl, imidazole, pyrrolidine, or other heterocyclic ring. disorders, such as severe dry skin, ichthyosis, age spots, The inventors have found that heterocyclic amines, such as melasma, lentigines, and skin changes associated with aging methenamine, are efficient in preventing or inhibiting the Therapeutic concentrations of N-acetylcysteine range from malodor produced by an organic thiol or similar malodor about 5% to about 10% in solution, oil-in-water lotion, or compounds, such as N-acetylcysteine. cream. These compositions, however, have a very unpleas 0018. The organic amines of preferred embodiments ant malodor similar to a rotten egg. Users of topical com include, for example, methenamine. Methenamine, also positions containing N-acetylcysteine may develop resis known as hexamethylenetetramine, is a white, odorless tance or become accustomed to the malodor, but the family heterocyclic compound with a Sweet taste, having the for members or bystanders may be disturbed by the objection mula CHN and a molecular weight of 140. Methenamine able and unpleasant odor of N-acetylcysteine released as in combination with mandelic acid, known as mandelamine, vapor pressure in the air. Because of Such shortcomings, may be used orally to treat urinary infections. Glucamine N-acetylcysteine has very limited commercial utilization for and Meglumine (N-methyl-glucamine) are aminocarbohy topical administration to human skin, nails, or hair. Dim drates. ethyl sulfone or methenamine for example, can effectively 0019. Other organic amines according to the present prevent or eliminate the malodor produced by N-acetylcys embodiments include, but are not limited to, adenine, aman teine in a composition containing water. tadine (1-adamantanamine), 2-adamantylamine, adenosine, 0013 Without being limited to a theory, it is believed that agmatine, agroclavine, 1-(2-aminoethyl)piperazine, the Sulfone or organic amine may trap or bind a thiol or 5-amino-4-imidazolecarboxamide, 2-aminoimidazole, similar malodor compounds to form a molecular complex 2-amino-2-methyl-1-propanol, 2-aminoperimidine, 3-ami through ionic/ionic, ionic/dipolar, and/or dipolar/dipolar noquinuclidine, 4-amino-2.2.6,6-tetramethylpiperidine, bonds that reduces the vapor pressure of the thiol or like 5-aminotetrazole, benzoctamine, benztropine, 1-benzylpip substance. The effect of these anti-odor ingredients is thus to erazine; 4.4-bipiperidine chlorhexidine, cocamine, creati reduce the presence or prevent the production of malodor, nine, cytidine, cytosine, dicocamine, diethanolamine, diiso and is not a masking effect. The inventors have found that propanolamine, dimethyl behenamine, dimethyl cocamine, the anti-odor effect of the anti-odor ingredients according to edamine, glucamine, guanine, guanosine, meglumine embodiments of the present invention is unrelated to the pH (N-methylglucamine), memantine, methenamine, morpho of the composition, and that the anti-odor effect is not a line, oleamine, piperazine, porphine, quinuclidine, 3-quinu relatively masking effect produced by a perfume or fragrant clidinol, quinupramine, rimantadine, Soyamine, soyamino Substance. In fact, the preferred pH of a composition is on propylamine, triethylenediamine, trizma base the acidic side ranging from about pH 3.0 to about pH 6.0, tris(hydroxymethyl)aminomethane), tropane, tromanta so that the active Substance, such as N-acetyl-cysteine, has dine, tromethamine (2-amino-2-hydroxymethyl-1,3-pro an optimal bioavailability to penetrate into the skin with panediol), tropine, and tropinone. minimal or no skin irritations. The compositions of the 0020 Preferred organic amines include amantadine, 1-(2- present embodiments have a pH of about 3.0 to about pH aminoethyl)piperazine, chlorhexidine, glucamine, meglu 6.5, preferably a pH of about 3.0 to about pH 6.0, and more mine (N-methylglucamine), memantine, methenamine, pip preferably a pH of about 3.5 to about pH 5.5. erazine, porphine, quinuclidine, 3-quinuclidinol, quinupramine, rimantadine, triethylenediamine, tropane, 0014. The sulfones according to preferred embodiments tromantadine, tropine, and tropinone. include Sulfonyl compounds, which may be represented by 0021 Many organic amines from commercial sources are the following generic structure: in Salt form, such as chlorhexidine gluconate and amanta dine hydrochloride. Such salt forms have been found to be less effective in preventing the malodor produced by thiol 0.015 where R and R are independently NH compounds. Therefore, the salt form of an organic amine NHCONH, NHC(=NH)NH, an alkyl, aralkyl, or aryl may be converted to a free base form by reaction with an group having 1 to 14 carbon atoms; and R and R may also inorganic alkali before use as an anti-odor Substance. carry OH, NH CONH, COOR NHCONH, NHC(=NH)NH, imidazole, pyrrolidine, or other hetero 0022. A thiol or similar malodor compounds used in the cyclic group; R is H, an alkyl, aralkyl or aryl group having formulation of a cosmetic or pharmaceutical composition 1 to 9 carbon atoms; and the H attached to any carbon atom may range in concentration, for example, from about 1% to may be substituted by I, F, Cl, Br, OH or alkoxy group about 50% by weight of the total composition. The concen having 1 to 9 carbon atoms. tration of a Sulfone or organic amine of the present embodi ments used to prevent the malodor formation by a thiol or 0016 Examples of sulfones according to preferred similar malodor compounds may range from about 0.1% to embodiments include, but are not limited to, dimethyl sul about 20% by weight of the total composition, and prefer fone, diethyl sulfone, diphenyl sulfone, methyl phenyl sul ably from about 1% to about 20% by weight of the total fone, dapsone; 4,4'-sulfonylbis(methylbenzoate); 4,4'-sulfo composition. US 2006/025 1597 A1 Nov. 9, 2006

0023 The inventors also have discovered that a novel propyl 3-hydroxybutanoate, isopropyl 3-hydroxypen anhydrous composition comprising a thiol or similar mal tanoate, and isopropyl tropate. odor compounds without the Sulfone or organic amine can effectively prevent the malodor formation. The inventors 0030) (2) N-Acetylamino Acid Esters believe that whereas common solvents such as water, etha 0031 (a) methyl N-acetyl-alaninate, methyl N-acetyl nol, propylene glycol and butylene glycol may enhance or argininate, methyl N-acetyl-asparaginate, dimethyl may not suppress malodor production by a thiol or similar N-acetyl-aspartate, methyl N-acetyl-glycinate, dimethyl malodor compounds, certain other solvents or ingredients N-acetyl-glutamate, methyl N-acetyl-glutaminate, methyl Such as isopropyl alcohol, n-propanol, ethyl acetoacetate, N-acetyl-histidinate, methyl N-acetyl-isoleucinate, methyl alpha-hydroxyacid esters (such as diethyl tartrate and tri N-acetyl-leucinate, methyl N-acetyl-lysinate, methyl ethyl citrate), and N-acetylamino acid esters (such as N-acetyl-phenylalaninate, methyl N-acetyl-prolinate, N-acetyl-L-proline ethyl ester and N-acetyl-L-proline pro methyl N-acetyl-serinate, methyl N-acetyl-threoninate, pyl ester) may effectively prevent malodor formation. The methyl N-acetyl-tryptophanate, methyl N-acetyl-tyrosinate, concentration of these solvents or ingredients in an anhy methyl N-acetyl-valinate, methyl N-acetyl-f-alaninate, drous composition may be about 1% or higher concentration methyl N-acetyl-y-aminobutanoate, methyl N-acetyl-3-ami by weight. noisobutanoate, methyl N-acetyl-citruilinate, methyl N-acetyl-homoserinate, methyl N-acetyl-ornithinate, methyl 0024 Representative solvents and other ingredients that N-acetyl-phenylglycinate, methyl N-acetyl-4-hydroxyphe may be used to prevent or Suppress malodor formation by a nylglycinate, and methyl N.O-diacetyl-4-hydroxyphenylg thiol or similar malodor compounds in an anhydrous com lycinate; position include, but are not limited to, the following alone or in various combination with one another: 0032 (b) ethyl N-acetyl-alaninate, ethyl N-acetyl-argini nate, ethyl N-acetyl-asparaginate, diethyl N-acetyl-aspar 0025 (1) Alpha-Hydroxyacid Esters tate, ethyl N-acetyl-glycinate, diethyl N-acetyl-glutamate, 0026 (a) methyl glycolate, methyl lactate, methyl 2-me ethyl N-acetyl-glutaminate, ethyl N-acetyl-histidinate, ethyl thylactate, methyl 2-hydroxybutanoate, methyl 2-hydroxy N-acetyl-isoleucinate, ethyl N-acetyl-leucinate, ethyl pentanoate, methyl 2-hydroxyhexanoate, methyl 2-hydroxy N-acetyl-lysinate, ethyl N-acetyl-phenylalaninate, ethyl heptanoate, methyl 2-hydroxyoctanoate, methyl N-acetyl-prolinate, ethyl N-acetyl-serinate, ethyl N-acetyl 2-hydroxyeicosanoate, methyl cerebronate, methyl 2-hy threoninate, ethyl N-acetyl-tryptophanate, ethyl N-acetyl droxynervonate, methyl mandelate, methyl benzilate, tyrosinate, ethyl N-acetyl-valinate, ethyl N-acetyl-B-alani methyl 3-phenylactate, methyl atrolactate, dimethyl malate, nate, ethyl N-acetyl-y-aminobutanoate, ethyl N-acetyl-3- dimethyl tartarate, trimethyl citrate, trimethyl isocitrate, aminoisobutanoate, ethyl N-acetyl-citrullinate, ethyl methyl 3-hydroxypropanoate, methyl 3-hydroxybutanoate, N-acetyl-homoserinate, ethyl N-acetyl-ornithinate, ethyl methyl 3-hydroxypentanoate and methyl tropate; N-acetyl-phenylglycinate, ethyl N-acetyl-4-hydroxyphe nylglycinate, and ethyl N, O-diacetyl-4-hydroxyphenylgly 0027 (b) ethyl glycolate, ethyl lactate, ethyl 2-methyl cinate; lactate, ethyl 2-hydroxybutanoate, ethyl 2-hydroxypen tanoate, ethyl 2-hydroxyhexanoate, ethyl 2-hydroxyhep 0033 (c) propyl N-acetyl-alaninate, propyl N-acetyl tanoate, ethyl 2-hydroxyoctanoate, ethyl argininate, propyl N-acetyl-asparaginate, dipropyl N-acetyl 2-hydroxyeicosanoate, ethyl cerebronate, ethyl 2-hydroxyn aspartate, propyl N-acetyl-glycinate, dipropyl N-acetyl ervonate, ethyl mandelate, ethyl benzilate, ethyl 3-phenyl glutamate, propyl N-acetyl-glutaminate, propyl N-acetyl lactate, ethyl atrolactate, diethyl malate, diethyl tartarate, histidinate, propyl N-acetyl-isoleucinate, propyl N-acetyl triethyl citrate, triethyl isocitrate, ethyl 3-hydroxypro leucinate, propyl N-acetyl-lysinate, propyl N-acetyl panoate, ethyl 3-hydroxybutanoate, ethyl 3-hydroxypen phenylalaninate, propyl N-acetyl-prolinate, propyl N-acetyl serinate, propyl N-acetyl-threoninate, propyl N-acetyl tanoate and ethyl tropate; tryptophanate, propyl N-acetyl-tyrosinate, propyl N-acetyl 0028 (c) propyl glycolate, propyl lactate, propyl 2-me valinate, propyl N-acetyl-3-alaninate, propyl N-acetyl-y- thylactate, propyl 2-hydroxybutanoate, propyl 2-hydroxy aminobutanoate, propyl N-acetyl-3-aminoisobutanoate, pentanoate, propyl 2-hydroxyhexanoate, propyl 2-hydroxy propyl N-acetyl-citruilinate, propyl N-acetyl-homoserinate, heptanoate, propyl 2-hydroxyoctanoate, propyl propyl N-acetyl-ornithinate, propyl N-acetyl-phenylglyci 2-hydroxyeicosanoate, propyl cerebronate, propyl 2-hy nate, propyl N-acetyl-4-hydroxyphenylglycinate, and propyl droxynervonate, propyl mandelate, propylbenzilate, propyl N.O-diacetyl-4-hydroxyphenylglycinate; and 3-phenylactate, propyl atrolactate, dipropyl malate, dipro 0034 (d) isopropyl N-acetyl-alaninate, isopropyl pyl tartarate, tripropyl citrate, tripropyl isocitrate, propyl N-acetyl-argininate, isopropyl N-acetyl-asparaginate, diiso 3-hydroxypropanoate, propyl 3-hydroxybutanoate, propyl propyl N-acetyl-aspartate, isopropyl N-acetyl-glycinate, 3-hydroxypentanoate, and propyl tropate; and diisopropyl N-acetyl-glutamate, isopropyl N-acetyl 0029 (d) isopropyl glycolate, isopropyl lactate, isopropyl glutaminate, isopropyl N-acetyl-histidinate, isopropyl 2-methylactate, isopropyl 2-hydroxybutanoate, isopropyl N-acetyl-isoleucinate, isopropyl N-acetyl-leucinate, isopro 2-hydroxypentanoate, isopropyl 2-hydroxyhexanoate, iso pyl N-acetyl-lysinate, isopropyl N-acetyl-phenylalaninate, propyl 2-hydroxyheptanoate, isopropyl 2-hydroxyoctanoate, isopropyl N-acetyl-prolinate, isopropyl N-acetyl-serinate, isopropyl 2-hydroxyeicosanoate, isopropyl cerebronate, iso isopropyl N-acetyl-threoninate, isopropyl N-acetyl-tryp propyl 2-hydroxynervonate, isopropyl mandelate, isopropyl tophanate, isopropyl N-acetyl-tyrosinate, isopropyl benzilate, isopropyl 3-phenylactate, isopropyl atrolactate, N-acetyl-valinate, isopropyl N-acetyl-3-alaninate, isopropyl diisopropyl malate, diisopropyl tartarate, triisopropyl citrate, N-acetyl-y-aminobutanoate, isopropyl N-acetyl-3-ami triisopropyl isocitrate, isopropyl 3-hydroxypropanoate, iso noisobutanoate, isopropyl N-acetyl-citrullinate, isopropyl US 2006/025 1597 A1 Nov. 9, 2006

N-acetyl-homoserinate, isopropyl N-acetyl-ornithinate, iso malodor Substance without a Sulfone or organic amine was propyl N-acetyl-phenylglycinate, isopropyl N-acetyl-4-hy used as the control. The test compositions and control were droxyphenylglycinate, and isopropyl N.O-diacetyl-4-hy judged by the panel for the anti-odor effect and the degree droxyphenylglycinate. of reducing the presence or preventing the production of malodor was recorded as (a) no effect (no difference from 0035 (3) Other Ingredients control), (b) slight malodor (50% effective), (c) trace mal 0.036 (a) butoxydiglycol, butoxyethanol, butoxypro odor (90% effective), and (d) no malodor (completely effec panol, butyl acetate, butanol, butyloctanol, cycloethoxyme tive). As an illustration, methenamine at 0.1% or higher thicone, cyclohexane, cyclomethicone, dibutyl adipate, concentration can completely eliminate the malodor pro disobutyl adipate, diisopropyl adipate, diisopropyl oxalate, duced by N-acetyl-L-cysteine 2% in oil-in-water emulsion. diisopropyl sebacate, dimethicone, dimethoxydiglycol, dim 0041. In the same manner, the degree of reducing the ethyl adipate, dimethyl glutarate, dioctyl adipate, dioctyl presence or preventing the production of malodor generated sebacate, dioctyl Succinate, dipropyl adipate, dipropylene by a thiol or similar malodor compounds in an anhydrous glycol, ethoxydiglycol, ethoxyethanol, 2-ethyl-1,3-hex composition containing a solvent or ingredient of the present anediol, isododecane, isooctane, isoparaffin, isopropyl embodiments was judged by three-member panel through acetate, isopropyl alcohol, isopropyl myristate, isopropyl olfactory sensor by Sniffing as (a) no difference from control, palmitate, methicone, octadecane, octanol, octyl benzoate, (b) slight malodor, (c) trace malodor, and (d) no malodor. In oleyl alcohol, oleyl lactate, PEG, phenyl methicone, n-pro an initial test, a solvent or liquid ingredient of the present panol, ethyl acetoacetate, methyl acetoacetate, propyl embodiments at 4.5 ml was added to a test tube, and a thiol acetoacetate, isopropyl acetoacetate, and silicone oil. or similar malodor compounds 0.5 g was added to make 0037. If an anhydrous composition is used for cosmetic 10% thiol or similar malodor compounds in the solution. conditions or pharmaceutical indications, a thiol or similar The control solution was prepared by dissolving a thiol or malodor compounds used in the formulation may range in similar malodor compounds 0.5 g in water 4.5 ml to make concentration from about 1% to about 50% by weight of the 10% aqueous solution. The above test solutions including total composition, for example. A solvent or ingredient of the control solutions were judged by the panel for the the present embodiments used to prevent the malodor for anti-odor effect and the degree of reducing the presence or mation by a thiol or similar malodor compounds may be preventing the production of malodor was recorded in the present in a composition at a concentration from about 1% same way as (a) no effect (no difference from control), (b) or higher concentration by weight of the total composition, slight malodor (50% effective), (c) trace malodor (90% preferably from about 1% to about 90% by weight of the effective), and (d) no malodor (completely effective). total composition, and more preferably from about 5% to 0042 Based on the above tests, the following solvents or about 80% by weight of the total composition. ingredients may be used to effectively prevent malodor 0038. The preferred solvents or ingredients that may be produced by a thiol or similar malodor compounds: benzyl used to prevent or Suppress malodor formation by a thiol or N-acetyl-prolinate, ethyl N-acetyl-prolinate, propyl similar malodor compounds in an anhydrous composition N-acetyl-prolinate, isopropyl N-acetyl-prolinate, butoxydig are benzyl N-acetyl-prolinate, ethyl N-acetyl-prolinate, pro lycol, butoxyethanol, butoxypropanol, butyl acetate, N-butyl pyl N-acetyl-prolinate, isopropyl N-acetyl-prolinate, diethyl alcohol, butylene glycol, butyl lactate, butyloctanol, cyclo tartrate, diisopropyl adipate, ethoxydiglycol, ethylglycolate, ethoxymethicone, cyclohexane, cyclomethicone, dibutyl ethyl lactate, ethyl acetoacetate, isopropyl alcohol, isopropyl adipate, diethyl tartrate, diisobutyl adipate, diisopropyl adi myristate, isopropyl palmitate, oleyl lactate, n-propanol, pate, diisopropyl oxalate, diisopropyl sebacate, dimethicone, silicone oil, triethylcitrate, tripropyl citrate, and triisopropyl dimethoxydiglycol, dimethyl adipate, dimethyl glutarate, dimethyl sulfone, dioctyl adipate, dioctyl sebacate, dioctyl citrate. Succinate, dipropyl adipate, dipropylene glycol, ethoxydig 0039. According to the present embodiments, there are lycol, ethoxyethanol, ethyl glycolate, 2-ethyl-1,3-hex two preferred options to formulate a composition to prevent anediol, ethyl lactate, ethyl acetoacetate, isododecane, or Suppress malodor formation by a thiol or similar malodor isooctane, isoparaffin, isopropyl acetate, isopropyl alcohol, compounds. One is to use a Sulfone or organic amine to isopropyl myristate, isopropyl palmitate, methicone, octa Suppress or prevent the malodor formation in a composition decane, octanol, octylbenzoate, oleyl alcohol, oleyl lactate, that contains water or alcohol. The other option is to PEG, phenyl methicone, n-propanol, silicone oil, triethyl formulate an anhydrous composition containing a certain citrate, triisopropyl citrate, and tripropyl citrate. Solvent or ingredient. 0043. In a combination composition, a cosmetic, phar 0040. The degree of reduction in the presence or produc maceutical, or other topically active agent may be incorpo tion of malodor produced by a thiol or similar malodor rated alone or in combination with one another into the compounds in a composition comprising a Sulfone or composition comprising an anti-odor ingredient and/or a organic amine was judged by a three-member panel through malodor compound according to embodiments of the present olfactory sensor by Sniffing as (a) no difference from control, invention. These topical agents may include, but are not (b) slight malodor, (c) trace malodor, and (d) no malodor. limited to: hydroxyacids, ketoacids and related compounds; Initially, a malodor compound Such as about 5% by weight phenyl alpha acyloxyalkanoic acids and derivatives; was prepared in water Solution or in oil-in-water emulsion. N-acetyl-aidosamines, N-acetylamino acids and related A Sulfone or organic amine of the present embodiments was N-acetyl compounds; local analgesics and anesthetics; anti added at various concentrations for example, ranging from acne agents; antibacterials; antiyeast agents; antifungal about 2%, 1%, 0.5% and 0.1% to the formulations contain agents; antiviral agents; antidandruff agents; antidermatitis ing the malodor Substance. The composition containing the agents; antihistamine agents; antipruritic agents; antiemet US 2006/025 1597 A1 Nov. 9, 2006 ics; antimotion sickness agents; antiinflammatory agents; floxacin, glucarolactone, gluconic acid, gluconolactone, glu antihyperkeratotic agents; antiperspirants; antipsoriatic curonic acid, glucuronolactone, glycolic acid, griseofulvin, agents; antiseborrheic agents; hair conditioners and hair guaifenesin, guanethidine, N-guanylhistamine, haloperidol. treatment agents; antiaging and antiwrinkle agents; Sunblock haloprogin, hexylresorcinol, homatropine, homosalate, and Sunscreen agents, skin lightening agents; depigmenting hydralazine, hydrochlorothiazide, hydrocortisone, hydrocor agents; astringents; cleansing agents; corn, callus and wart tisone 21-acetate, hydrocortisone 17-butyrate, hydrocorti removing agents; topical cardiovascular agents; vitamins; Sone 17-Valerate, hydrogen peroxide, hydromorphone, hyd corticosteroids; tanning agents; hormones; retinoids; and roquinone, hydroquinone monoether, hydroxy Zine, gum disease or oral care agents. hyoscyamine, hypoxanthine, ibuprofen, ichthammol. idaru 0044) Examples of other topically active agents that may bicin, imatinib, imipramine, imiquimod, indinavir, be added to the compositions of the present embodiments indomethacin, irbesartan, irinotecan, isoetharine, isoproter include, but are not limited to: abacavir, acebutolol, acetami enol, itraconazole, kanamycin, ketamine, ketanserin, keto nophen, acetaminosalol, acetazolamide, acetohydroxamic conazole, ketoprofen, ketotifen, kojic acid, labetalol, lactic acid, acetylsalicylic acid, acitretin, aclovate, acrivastine, acid, lactobionic acid, lamivudine, lamotrigine, lanSopra actiq, acyclovir, adapalene, adefovir dipivoxil, adenosine, Zole, letrozole, leuprolide, levalbuterol, levofloxacin, albuterol, alfuZosin, allopurinol, alloxanthine, almotriptan, lidocaine, lineZolid, lobetine, loperamide, losartan, loxapine, alprazolam, alprenolol, aluminum acetate, aluminum chlo lysergic diethylamide, mafenide, malic acid, mattobionic ride, aluminum chlorohydroxide, aluminum hydroxide, acid, mandelic acid, maprotiline, mebendazole, mecamy amantadine, amiloride, aminacrine, aminobenzoic acid lamime, meclizine, meclocycline, memantine, menthol, (PABA), aminocaproic acid, aminosalicylic acid, amio meperidine, mepivacaine, mescaline, metanephrine, metap darone, amitriptyline, amlodipine, amocarzine, amodiaquin, roterenol, metaraminol, metformrin, methadone, metham amorolfine, amoxapine, amphetamine, amplicillin, phetamine, methotrexate, methoxamine, methyldopa esters, anagrelide, anastroZole, anthralin, apomorphine, aprepitant, methyldopamide, 3.4-methylenedioxymethamphetamine, arbutin, aripiprazole, ascorbic acid, ascorbyl palmitate, ata methylactic acid, methyl nicotinate, methylphenidate, Zanavir, atenolol, atomoxetine, atropine, azathioprine, aze methyl salicylate, metiamide, metolaZone, metoprolol, met laic acid, azelastine, azithromycin, bacitracin, beclometha ronidazole, mexiletine, miconazole, midazolam, midodrine, SO dipropionate, bemegride, benazepril, miglustat, minocycline, minoxidil, mirtazapine, mitox bendroflumethiazide, benzocaine, benzonatate, benzophe antrone, moexiprilat, molindone, monobenzone, morphine, none, benzoyl peroxide, benztropine, bepridil, betametha moxifloxacin, moxonidine, mupirocin, nadolol, naftifine, Sone dipropionate, betamethasone Valerate, brimonidine, nalbuphine, nalmefene, naloxone, naproxen, nefazodone, brompheniramine, bupivacaine, buprenorphine, bupropion, nelfinavir, neomycin, nevirapine, nicardipine, nicotine, nife burimamide, butenafine, butoconazole, cabergoline, caffeic dipine, nimodipine, nisoldipine, nizatidine, norepinephrine, acid, caffeine, calcipotriene, camphor, candesartan cilexetil, nystatin, octopamine, octreotide, octyl methoxycinnamate, capsaicin, carbamazepine, carbamide peroxide, cefditoren octyl salicylate, ofloxacin, olanzapine, olmesartan medox pivoxil, cefepime, cefpodoxime proxetil, celecoxib, cetiriz omil, olopatadine, omeprazole, ondansetron, oxiconazole, ine, cevimeline, chitosan, chlordiazepoxide, chlorhexidine, oxotremorine, oxybenzone, oxybutynin, oxycodone, chloroquine, chlorothiazide, chloroxylenol, chlorphe oxymetazoline, padimate O, palonosetron, pantothenic acid, niramine, chlorpromazine, chlorpropamide, ciclopiroX, cil pantoyl lactone, paroxetine, pemoline, penciclovir, penicil ostaZol, cimetidine, cinacalcet, ciprofloxacin, citalopram, lamine, penicillins, pentazocine, pentobarbital, pentostatin, citric acid, cladribine, clarithromycin, clemastine, clindamy pentoxifylline, pergolide, perindopril, permethrin, phencyc cin, clioquinol, clobetasol propionate, clomiphene, cloni lidine, pheneizine, pheniramine, phenmetrazine, phenobar dine, clopidogrel, clotrimazole, clozapine, codeine, cro bital, phenol, phenoxybenzamine, phentolamine, phenyle molyn, crotamiton, cyclizine, cyclobenzaprine, cycloserine, phrine, phenylpropanolamine, phenytoin, physostigmine, cytarabine, dacarbazine, dalfopristin, dapsone, daptomycin, pilocarpine, pimozide, pindolol, pioglitaZone, pipamazine, daunorubicin, deferoxamine, dehydroepiandrosterone, piperonyl butoxide, pirenzepine, podofilox, podophyllin, delavirdine, desipramine, desloratadine, desmopressin, des poVidone iodine, pramipexole, pramoxine, praZosin, pred Oximetasone, dexamethasone, dexmedetomidine, dexmeth nisone, prenalterol, prilocaine, procainamide, procaine, pro ylphenidate, dexraZoxane, dextroamphetamine, diazepam, carbazine, promazine, promethazine, promethazine propi dicyclomine, didanosine, dihydrocodeine, dihydrornor Onate, propafenone, propoxyphene, propranolol. phine, diltiazem, diphenhydramine, diphenoxylate, dipy propylthiouracil, protriptyline, pseudoephedrine, pyrethrin, ridamole, disopyramide, dobutamine, dolfetilide, dolasetron, pyrilamine, pyrimethamine, quetiapine, quinapril, quineth donepezil, dopa esters, dopamide, dopamine, dorzolamide, aZone, quinidine, quinupristin, rabeprazole, reserpine, resor doxepin, doxorubicin, doxycycline, doxylamine, doxypin, cinol, retinal, 13-cis retinoic acid, retinoic acid, retinol, dulloxetine, dyclonine, econazole, eflornithine, eletriptan, retinyl acetate, retinyl palmitate, ribavirin, ribonic acid, emitricitabine, enalapril, ephedrine, epinephrine, epinine, ribonolactone, rifampin, rifapentine, rifaximin, riluzole, epirubicin, eptifibatide, ergotamine, erythromycin, escitalo rimantadine, risedronic acid, risperidone, ritodrine, rivastig pram, esmolol, esomeprazole, estazolam, estradiol. mine, rizatriptan, ropinirole, ropivacaine, Salicylamide, Sali ethacrynic acid, ethinyl estradiol, etidocaine, etomidate, cylic acid, Salmeterol, Scopolamine, Selegiline, selenium famciclovir, famotidine, felodipine, fentanyl, ferulic acid, Sulfide, serotonin, sertindole, Sertraline, shale tar, Sibutra fexofenadine, flecainide, fluconazole, flucytosine, fluocino mine, sildenafil. Sotalol, streptomycin, Strychnine, Sulcona lone acetonide, fluocinonide, 5-fluorouracil, fluoxetine, Zole, Sulfabenz, Sulfabenzamide, Sulfabromomethazine, Sul fluiphenazine, flurazepam, fluvoxamine, formoterol, furo facetamide, Sulfachiorpyridazine, Sulfacytine, Sulfadiazine, semide, galactarolactone, galactonic acid, galactonolactone, Sulfadimethoxine, Sulfadoxine, Sulfaguanole, Sulfalene, Sul galantamine, gatifloxacin, gefitinib, gemcitabine, gemi famethizole, Sulfamethoxazole, Sulfanilamide, Sulfapyra US 2006/025 1597 A1 Nov. 9, 2006

Zine, Sulfapyridine, SulfaSalazine, Sulfasomizole, Sulfathia 0049. A topical composition also may be formulated into Zole, Sulfisoxazole, Sulfur, tadalafil. tamsulosin, tartaric acid, a gel or shampoo form. A typical gel composition is formu tazarotene, tegaserol, tellithromycin, telmisartan, temozolo lated by the addition of a gelling agent, Such as chitosan, mide, tenofovir disoproxil, terazosin, terbinafine, terbuta methyl cellulose, ethyl cellulose, polyvinyl alcohol, line, terconazole, terfenadine, tetracaine, tetracycline, tet polyduaterniums, hydroxyethylcellulose, hydroxypropylcel rahydrozoline, theobromine, theophylline, thiabendazole, lulose, hydroxypropylmethylcellulose, carbomer, or ammo thioctic acid (lipoic acid), thioridazine, thiothixene, thymol. niated glycyrrhizinate, to a solution comprising a thiol or tiagabine, timolol, tinidazole, tioconazole, tirofiban, tizani similar malodor compounds and a sulfone or organic amine dine, tobramycin, tocainide, tolaZoline, tolbutamide, tolnaf of the present embodiments. The preferred concentration of tate, tolterodine, tramadol, tranylcypromine, traZodone, tri the gelling agent may range, for example, from about 0.1% amcinolone acetonide, triamcinolone diacetate, to about 2% by weight of the total composition. In the triamcinolone hexacetonide, triamterene, triazolam, tri preparation of a shampoo, the organic amine of the present closan, triflupromazine, trimethoprim, trimipramine, tripe embodiments and the thiol or similar malodor compounds lennamine, triprolidine, tromethamine, tropic acid, may be dissolved in water or propylene glycol, and the tyramine, undecylenic acid, urea, urocanic acid, ursodiol. solution thus obtained is mixed with a shampoo base. The Vardenafil. Venlafaxine, Verapamil, vitamin E acetate, Vori concentration of the thiol or similar malodor compounds conazole, warfarin, wood tar, Xanthine, Zafirlukast, Zaleplon, may range from about 0.1% to about 99% by weight of the Zinc pyrithione, Ziprasidone, Zolmitriptan, and Zolpidem. total composition, with preferred concentration of from about 0.5% to about 70% by weight of the total composition, 0045 General Preparations and with more preferred concentration of from about 1% to 0046 Compositions comprising a thiol or similar mal about 50% by weight of the total composition. The concen odor compounds and a Sulfone or organic amine of the tration of the Sulfone or organic amine may range from about embodiments may be formulated, for example, as solution, 0.01% to about 90% by weight of the total composition, with gel, lotion, cream, ointment, shampoo, spray, Stick, powder, preferred concentration of from about 0.05% to about 50% masque, mouth rinse or wash, vaginal gel or preparation, or by weight of the total composition, and with more preferred otherform acceptable for use on skin, nail, hair, oral mucosa, concentration of from about 0.1% to about 20% by weight vaginal or anal mucosa, mouth or gums. of the total composition. 0047. To prepare a solution composition, at least one 0050. To prepare an anhydrous composition according to Sulfone or organic amine of the present embodiments and at the present embodiments, a thiol or similar malodor com least one thiol or similar malodor compounds are dissolved pounds may be dissolved in an organic Solvent or ingredient in a solution prepared from water, ethanol, propylene glycol, of the present embodiments, and other solvents and ingre butylene glycol, and/or other topically acceptable vehicle. dients (excluding water, ethanol, propylene glycol and buty The concentration of the thiol or similar malodor com lene glycol) may be added to the solution. The concentration pounds may range from about 0.1% to about 99% by weight of the thiol or similar malodor compounds may range from of the total composition, with preferred concentration of about 0.1% to about 99% by weight of the total composition, from about 0.5% to about 70% by weight of the total with preferred concentration of from about 1% to about 70% composition and with more preferred concentration of from by weight of the total composition and with more preferred about 1% to about 50% by weight of the total composition. concentration of from about 1% to about 50% by weight of The concentration of the Sulfone or organic amine may range the total composition. The concentration of each solvent or from about 0.01% to about 90% by weight of the total ingredient, or the combined total concentration of the Sol composition, with preferred concentration of from about vents and ingredients of the present invention may range 0.05% to about 50% by weight of the total composition, and from about 1% to about 99% by weight of the total com with more preferred concentration of from about 0.1% to position, with preferred concentration of from about 5% to about 20% by weight of the total composition. about 85% by weight of the total composition, and with more preferred concentration of from about 10% to about 0.048. To prepare a topical composition in lotion, cream 80% by weight of the total composition. or ointment form, the Sulfone or organic amine of the present embodiments and a thiol or similar malodor compounds are 0051. An anhydrous composition comprising a thiol or dissolved first in water, ethanol, propylene glycol, and/or similar malodor compounds and a solvent or ingredient of other topically acceptable vehicle, and the solution thus the present embodiments also may be formulated by those obtained is mixed with a desired base or pharmaceutically skilled in the art as a gel, lotion, cream, ointment, shampoo, acceptable vehicle to make lotion, cream or ointment. The spray, Stick, powder, masque or other form acceptable for concentration of the thiol or similar malodor compounds use on skin, nail, hair, oral mucosa, vaginal or anal mucosa, may range from about 0.1% to about 99% by weight of the mouth or gums. The concentration of the thiol or similar total composition, with preferred concentration of from malodor compounds may range from about 0.1% to about about 0.5% to about 70% by weight of the total composition, 99% by weight of the total composition, with preferred and with more preferred concentration of from about 1% to concentration of from about 1% to about 70% by weight of about 50% by weight of the total composition. The concen the total composition and with more preferred concentration tration of the Sulfone or organic amine may range from about of from about 1% to about 50% by weight of the total 0.01% to about 90% by weight of the total composition, with composition. The concentration of each solvent or ingredi preferred concentration of from about 0.05% to about 50% ent, or the combined total concentration of the solvents and by weight of the total composition and with more preferred ingredients of the present invention may range from about concentration of from about 0.1% to about 20% by weight 1% to about 99% by weight of the total composition, with of the total composition. preferred concentration of from about 5% to about 85% by US 2006/025 1597 A1 Nov. 9, 2006 weight of the total composition, and with more preferred body. The above practices may serve to eliminate the concentration of from about 10% to about 80% by weight of malodor produced by the thiol or similar malodor com the total composition. pounds. 0.052 To prepare a combination, a cosmetic, pharmaceu 0055. The examples that follow describe representative tical, or other topically active agent is incorporated into any experiments conducted to identify compositions according to the present embodiments, which are useful, for example, one of the above compositions by dissolving or mixing the in the topical prevention or treatment of various cosmetic agent into the formulation. Other forms of compositions for conditions, dermatological indications, and other disorders, topical delivery of active ingredients are readily blended, Such as melasma, age spots and wrinkles. The following prepared or formulated by those skilled in the art. examples are illustrative, but not limiting, of the methods 0053. Many thiols and similar malodor compounds, such and compositions of the present embodiments. Other Suit as N-acetyl-cysteine, glutathione, and dihydrolipoic acid, able modifications and adaptations of the variety of condi are potent antioxidants and are topically effective for plump tions and parameters normally encountered in the prepara ing the skin; for increasing skin thickness by stimulating tion and use of the compositions, and that are obvious to biosynthesis of collagen and glycosaminoglycans; and for those skilled in the art, are within the spirit and scope of the prevention or treatment of various cosmetic conditions, embodiments. dermatological indications, and other disorders. These con EXAMPLE 1. ditions, indications, and disorders include, for example, deranged or disordered cutaneous tissues relevant to skin, 0056 N-Acetyl-L-cysteine 10 g was dissolved in water nail and hair; oral, vaginal and anal mucosa; promotion of 20 ml and the solution thus obtained was mixed with wound healing; disturbed keratinization; inflammation; and hydrophilic ointment or oil-in-water emulsion 70 g. The changes associated with intrinsic and extrinsic aging. The cream composition thus prepared contained 10% N-acetyl manifestations of these conditions, indications, and disor L-cysteine and had very unpleasant malodor, as judged by ders include, but are not limited to, acne; age spots; blem three-member panel through olfactory sensor by Sniffing. ished skin; blotches; cellulite; dermatoses; dandruff dry 0057 N-Acetyl-L-cysteine 10 g and methenamine 3 g skin; eczema: elastosis; herpes; hyperkeratosis; hyperpig were dissolved in water 20 ml and the solution thus obtained mented skin; severe dry skin, ichthyosis; keratoses; lentigi was mixed with hydrophilic ointment or oil-in-water emul nes; melasmas; mottled skin; pseudofolliculitis barbae; pho sion 67 g. The cream thus prepared contained 10% N-acetyl toaging and photodamage; pruritus; psoriasis; skin lines; L-cysteine and 3% methenamine, and the composition did stretch marks; thinning of skin, nail plate and hair, warts; not have any malodor as judged by the panel. This result wrinkles: Xerosis; oral or gum disease; irritated, inflamed, shows that methenamine of the present embodiments can unhealthy, damaged or abnormal mucosa, skin, hair, nail, effectively eliminate or prevent the malodor of N-acetyl-L- nostril, ear canal, anal or vaginal conditions; defective cysteine in a cream or oil-in-water emulsion. The compo synthesis or repair of dermal components; abnormal or sition may be used, for example, in the topical prevention or diminished synthesis of collagen, glycosaminoglycans, pro treatment of various cosmetic conditions, dermatological teoglycans and elastin as well as diminished levels of Such indications and other disorders including, but not limited to, components in the dermis; uneven and rough Surface of skin, melasma, age spots and wrinkles. nail and hair, loss or reduction of skin, nail and hair resiliency, elasticity and recoilability; lack of skin, nail and EXAMPLE 2 hair lubricants and luster, fragility and splitting of nail and hair, yellowing skin; reactive, irritating or telangiectatic 0058 N-Acetyl-L-cysteine 10 g and meglumine (N-me skin; dull and older-looking skin, nail and hair; for skin thyl-glucamine) 10 g were dissolved in water 20 ml and the bleach and lightening and wound healing. solution thus obtained was mixed with hydrophilic ointment or oil-in-water emulsion 60 g. The cream thus prepared 0054 The anti-odor or malodor preventing composition contained 10% N-acetyl-L-cysteine and 10% meglumine, according to the present embodiments may widen the hori and the composition had a trace of faint odor as judged by Zon of applications and broaden the commercial utilities the panel. This result shows that meglumine of the present because the composition does not have unpleasant malodor. embodiments can Substantially eliminate or prevent the Thus, the present embodiments may be practiced in various malodor produced by N-acetyl-L-cysteine in a cream or ways by those skilled in the art. For example, instead of a oil-in-water emulsion. The composition may be used, for single composition comprising both a malodor thiol com example, in the topical prevention or treatment of various pound and an anti-odor Substance of the present embodi cosmetic conditions, dermatological indications and other ments, there may be two compositions; one comprises a thiol disorders including, but not limited to, melasma, age spots compound and the other an anti-odor Substance. The two and wrinkles. compositions may be topically applied to the skin or other site of the body simultaneously or alternatively in any order EXAMPLE 3 of application. In another example, an applicator may be 0059 An anti-odor test was carried out as follows: utilized that contains two chambers or compartments; one N-Acetyl-L-cysteine (MW 163) 8.15 g was dissolved in comprising a malodor thiol compound either in powder or water, and the total volume was 100 ml. This solution liquid form, and the other comprising an anti-odor Substance contained N-Acetyl-L-cysteine 0.5 M or 81.5 mg per ml of the present embodiments. When the applicator is N-Acetyl-L-cysteine. Methenamine (MW 140) 7.0 g was Squeezed or pumped, the compositions in the two chambers dissolved in water, and the total volume was 100 ml. This may be delivered simultaneously and/or mixed instantly solution contained methenamine 0.5M or 70 mg per ml before contacting or reaching the skin or other sites of the methenamine. US 2006/025 1597 A1 Nov. 9, 2006

0060. In a first experiment, the above 0.5 M N-acetyl-L- 0068. In a first experiment, the above 0.5 M N-acetyl-L- cysteine 10 ml was mixed with 0.5 M methenamine 5 ml and cysteine 10 ml was mixed with 0.5 M piperazine 5 ml and water 5 ml. The final composition had pH 5.2, and contained water 5 ml. The final composition had a pH 5.6, and N-acetyl-L-cysteine 4% and methenamine 1.8%. This com contained N-acetyl-L-cysteine 4% and piperazine 1.1%. position did not have any malodor as judged by the panel. This composition had a slight malodor and was 50% effec The composition may be used, for example, in the topical tive in preventing odor as judged by the panel. prevention or treatment of various cosmetic conditions, 0069. In a second experiment, the above 0.5 M N-acetyl dermatological indications and other disorders including, L-cysteine 25 ml was mixed with 0.5M piperazine 5 ml and but not limited to, melasma, age spots and wrinkles. water 20 ml. The final composition had pH 3.4, and con 0061. In a second experiment, the above 0.5 M N-acetyl tained N-acetyl-L-cysteine 4% and piperazine 0.43%. This L-cysteine 25 ml was mixed with 0.5 M methenamine 5 ml composition had a slight malodor and was 50% effective in and water 20 ml. The final composition had pH 3.9, and preventing odor as judged by the panel. contained N-acetyl-L-cysteine 4% and methenamine 0.7%. 0070 These compositions may be used, for example, in This composition did not have any malodoras judged by the the topical prevention or treatment of various cosmetic panel. The composition may be used, for example, in the conditions, dermatological indications and other disorders topical prevention or treatment of various cosmetic condi including, but not limited to, melasma, age spots and tions, dermatological indications and other disorders includ wrinkles. ing, but not limited to, melasma, age spots and wrinkles. 0062) These compositions may be used, for example, in EXAMPLE 6 the topical prevention or treatment of various cosmetic 0071 An anti-odor test was carried out as follows: conditions, dermatological indications and other disorders N-Acetyl-L-cysteine (163) 8.15 g was dissolved in water, including, but not limited to, melasma, age spots and and the total volume was 100 ml. This solution contained wrinkles. N-Acetyl-L-cysteine 0.5 M, or 81.5 mg per ml N-Acetyl L-cysteine. Trizma base (MW 121) 6.05 g was dissolved in EXAMPLE 4 water, and the total volume was 100 ml. This solution 0063 An anti-odor test was carried out as follows: contained trizma base 0.5M, or 60.5 mg per ml trizma base. N-Acetyl-L-cysteine (MW 163) 8.15 g was dissolved in 0072. In a first experiment, the above 0.5 M N-acetyl-L- water, and the total volume was 100 ml. This solution cysteine 10 ml was mixed with 0.5 M trizma base 5 ml and contained N-Acetyl-L-cysteine 0.5 M or 81.5 mg per ml water 5 ml. The final composition had pH 3.5, and contained N-Acetyl-L-cysteine. Meglumine (N-methyl-D-glucamine, N-acetyl-L-cysteine 4% and trizma base 1.5%. This com MW 195) 9.75 g was dissolved in water, and the total position had a slight malodor and was 50% effective in volume was 100 ml. This solution contained meglumine 0.5 preventing odor as judged by the panel. M or 98 mg per ml meglumine. 0073. In a second experiment, the above 0.5 M N-acetyl 0064. In a first experiment, the above 0.5 M N-acetyl-L- L-cysteine 25 ml was mixed with 0.5 M trizma base 5 ml and cysteine 10 ml was mixed with 0.5 M meglumine 5 ml and water 20 ml. The final composition had pH 3.0, and con water 5 ml. The final composition had pH 3.4 and contained tained N-acetyl-L-cysteine 4% and trizma base 0.61%. This N-acetyl-L-cysteine 4% and meglumine 2.5%. This compo composition had a slight malodor and was 50% effective in sition had a trace malodor and was 90% effective in pre preventing odor as judged by the panel. venting odor as judged by the panel. 0074 These compositions may be used, for example, in 0065. In a second experiment, the above 0.5 M N-acetyl the topical prevention or treatment of various cosmetic L-cysteine 25 ml was mixed with 0.5 M meglumine 5 ml and conditions, dermatological indications and other disorders water 20 ml. The final composition had pH 2.9, and con including, but not limited to, melasma, age spots and tained N-acetyl-L-cysteine 4% and meglumine 0.98%. This wrinkles. composition had a slight malodor and was 50% effective in preventing odor as judged by the panel. EXAMPLE 7 0.066 These compositions may be used, for example, in 0075 An anti-odor test was carried out as follows: the topical prevention or treatment of various cosmetic N-Acetyl-L-cysteine (MW 163) 8.15 g was dissolved in conditions, dermatological indications and other disorders water, and the total volume was 100 ml. This solution including, but not limited to, melasma, age spots and contained N-Acetyl-L-cysteine 0.5 M or 81.5 mg per ml wrinkles. N-Acetyl-L-cysteine. Chlorhexidine base (MW 505) 1.01 g was suspended in water, and the total volume was 100 ml. EXAMPLE 5 This suspension contained chlorhexidine base 0.2 M or 10.1 0067. An anti-odor test was carried out as follows: mg per ml chlorhexidine base. N-Acetyl-L-cysteine (MW 163) 8.15 g was dissolved in 0076) The above 0.5 M N-acetyl-L-cysteine 5 ml was water, and the total volume was 100 ml. This solution mixed with 0.2 M chlorhexidine base 5 ml. The final contained N-Acetyl-L-cysteine 0.5 M or 81.5 mg per ml composition contained N-acetyl-L-cysteine 0.25 M and N-Acetyl-L-cysteine. Piperazine (MW 86) 4.3 g was dis chlorhexidine 0.1 M. This composition had a slight malodor solved in water, and the total volume was 100 ml. This and was 50% effective in preventing odor as judged by the Solution contained piperazine 0.5M, or 43 mg per ml pip panel. The composition may be used, for example, in the erazine. topical prevention or treatment of various cosmetic condi US 2006/025 1597 A1 Nov. 9, 2006

tions, dermatological indications and other disorders includ was 50% effective in preventing malodor as judged by the ing, but not limited to, melasma, age spots and wrinkles. panel. The composition may be used, for example, in the topical prevention or treatment of various cosmetic condi EXAMPLE 8 tions, dermatological indications and other disorders includ 0077. An anti-odor test was carried out as follows: ing, but not limited to, melasma, age spots and wrinkles. N-Acetyl-L-cysteine (MW 163) 8.15 g was dissolved in water, and the total volume was 100 ml. This solution EXAMPLE 12 contained N-Acetyl-L-cysteine 0.5 M or 81.5 mg per ml 0081. An anti-odor test was also carried out as follows: N-Acetyl-L-cysteine. The above 0.5 M N-Acetyl-L-cysteine N-Acetyl-L-cysteine (MW 163) 8.15 g was dissolved in 50 ml was mixed with 30 ml water containing 1 g cytidine water, and the total volume was 100 ml. This solution (MW 243), and the final volume was made up to 100 ml with contained N-Acetyl-L-cysteine 0.5 M, or 81.5 mg per ml water. This solution had pH 4.3 and contained 4% N-acetyl N-Acetyl-L-cysteine. The above 0.5 M N-Acetyl-L-cysteine L-cysteine and 1% cytidine. This composition had a trace 50 ml was mixed with 30 ml water containing 1 g guanine malodor and was 90% effective in preventing odor as judged (MW 151), and the final volume was made up to 100 ml with by the panel. This result shows that cytidine may substan water. This solution contained 4% N-Acetyl-L-cysteine and tially prevent the malodor produced by N-Acetyl-L-cys 1% guanine. This composition had a slight malodor and was teine. The composition may be used, for example, in the 50% effective in preventing malodor as judged by the panel. topical prevention or treatment of various cosmetic condi The composition may be used, for example, in the topical tions, dermatological indications and other disorders includ prevention or treatment of various cosmetic conditions, ing, but not limited to, melasma, age spots and wrinkles. dermatological indications and other disorders including, but not limited to, melasma, age spots and wrinkles. EXAMPLE 9 0078. An anti-odor test was carried out as follows: EXAMPLE 13 N-Acetyl-L-cysteine (MW 163) 8.15 g was dissolved in 0082 An anti-odor test was carried out as follows. water, and the total volume was 100 ml. This solution N-Acetyl-L-cysteine (MW 163) 8.15 g was dissolved in contained N-Acetyl-L-cysteine 0.5 M, or 81.5 mg per ml water, and the total volume was 100 ml. This solution N-Acetyl-L-cysteine. The above 0.5 M N-Acetyl-L-cysteine contained N-Acetyl-L-cysteine 0.5 M or 81.5 mg per ml 50 ml was mixed with 30 ml water containing 1 g cytosine N-Acetyl-L-cysteine. The above 0.5 M N-Acetyl-L-cysteine (MW 111), and the final volume was made up to 100 ml with 50 ml was mixed with 30 ml water containing 1 g guanosine water. This solution contained 4% N-Acetyl-L-cysteine and (MW 283), and the final volume was made up to 100 ml with 1% cyosine. This composition had a slight malodor and was water. This solution contained 4% N-Acetyl-L-cysteine and 50% effective in preventing malodor as judged by the panel. 1% guanosine. This composition had a slight malodor and The composition may be used, for example, in the topical was 50% effective in preventing malodor as judged by the prevention or treatment of various cosmetic conditions, panel. The composition may be used, for example, in the dermatological indications and other disorders including, topical prevention or treatment of various cosmetic condi but not limited to, melasma, age spots and wrinkles. tions, dermatological indications and other disorders includ ing, but not limited to, melasma, age spots and wrinkles. EXAMPLE 10 0079 An anti-odor test was carried out as follows: EXAMPLE 1.4 N-Acetyl-L-cysteine (MW 163) 8.15 g was dissolved in 0083. An anti-odor test was carried out in an anhydrous water, and the total volume was 100 ml. This solution Solvent according to the following example. In a series of contained N-Acetyl-L-cysteine 0.5 M or 81.5 mg per ml test tubes, 4.5 ml of a solvent was added to a test tube such N-Acetyl-L-cysteine. The above 0.5 M N-Acetyl-L-cysteine that each test tube comprised a single solvent. The solvents 50 ml was mixed with 30 ml water containing 1 g adenine added to the test tubes included water, ethanol, acetone, (MW 135), and the final volume was made up to 100 ml with n-propanol, isopropyl alcohol, propylene glycol, butylenes water. This solution contained 4% N-Acetyl-L-cysteine and glycol, benzyl alcohol, ethoxydiglycol, 2-ethyl-1,3-hex 1% adenine. This composition had a slight malodor and was anediol. N-Acetyl-L-cysteine (MW 163) 0.5 g was then 50% effective in preventing malodor as judged by the panel. added and dissolved in each solvent. The test tubes were The composition may be used, for example, in the topical warmed slightly to enhance dissolution of N-acetyl-L-cys prevention or treatment of various cosmetic conditions, teine crystals. Each test tube contained 10% N-acetyl-L- dermatological indications and other disorders including, cysteine and 90% solvent. but not limited to, melasma, age spots and wrinkles. 0084. The panel judged the anti-odor effect in each test EXAMPLE 11 tube. We found that water, ethanol, propylene glycol, and 0080. An anti-odor test was carried out as follows: butylene glycol each did not Suppress the malodor. On the N-Acetyl-L-cysteine (MW 163) 8.15 g was dissolved in other hand, acetone, n-propanol, isopropyl alcohol, benzyl water, and the total volume was 100 ml. This solution alcohol, ethoxydiglycol, and 2-ethyl-1,3-hexanediol each contained N-Acetyl-L-cysteine 0.5 M, or 81.5 mg per ml effectively prevented the malodor produced by N-acetyl-L- N-Acetyl-L-cysteine. The above 0.5 M N-Acetyl-L-cysteine cysteine. The anti-odor effect by acetone, n-propanol, iso 50 ml was mixed with 30 ml water containing 1 g adenosine propyl alcohol, benzyl alcohol, ethoxydiglycol, and 2-ethyl (MW 267), and the final volume was made up to 100 ml with 1.3-hexanediol was judged to be 100%. water. This solution contained 4% N-Acetyl-L-cysteine and 0085. The anhydrous composition comprising 10% 1% adenosine. This composition had a slight malodor and N-acetyl-L-cysteine and 90% solvent(s) selected, singly or US 2006/025 1597 A1 Nov. 9, 2006 in combination, from acetone, n-propanol, isopropyl alco prepared from isopropyl alcohol 50 parts, diethyl tartarate hol, benzyl alcohol, ethoxydiglycol and 2-ethyl-1,3-hex 25 parts, and triethylcitrate 25 parts volume by volume. This anediol does not have malodor, and may be used, for Solution contained 2% N-propanoyl-L-cysteine in an anhy example, in the topical prevention or treatment of various drous composition, and did not have any malodor as judged cosmetic conditions, dermatological indications and other by the panel. The composition may be used, for example, in disorders including melasma, age spots and wrinkles. the topical prevention or treatment of various cosmetic conditions, dermatological indications and other disorders EXAMPLE 1.5 including, but not limited to, melasma, age spots and 0.086 An anti-odor test was carried out in an anhydrous wrinkles. composition according to the following example. In a series of test tubes, 4.5 ml of a liquid ingredient was added to a test EXAMPLE 19 tube such that each test tube comprised a single liquid 0091 An anti-odor test was carried out as follows: ingredient. The liquid ingredients added to a test tube N-Acetyl-L-glutathione, 2 g was dissolved in 98 ml solution included ethyl glycolate, ethyl-L-lactate, diethyl tartrate, prepared from isopropyl alcohol 50 parts, diethyl tartarate triethylcitrate, tripropyl citrate, ethyl-DL-mandelate, benzyl 25 parts and triethylcitrate 25 parts volume by volume. This N-acetyl-prolinate, ethyl N-acetyl-prolinate, propyl Solution contained 2% N-acetyl-L-glutathione in an anhy N-acetyl-prolinate. N-Acetyl-L-cysteine (MW 163) 0.5 g. drous composition, and did not have any malodor as judged was then added and dissolved in each liquid ingredient. The by the panel. The composition may be used, for example, in test tubes were warmed slightly to enhance dissolution of the topical prevention or treatment of various cosmetic N-acetyl-L-cysteine crystals. Each test tube contained 10% conditions, dermatological indications and other disorders N-acetyl-L-cysteine and 90% liquid ingredient. The panel including, but not limited to, melasma, age spots and judged the anti-odor effect in each test tube. We found that wrinkles. the above liquid ingredients effectively prevented the mal odor produced by N-acetyl-L-cysteine. The anti-odor effect EXAMPLE 20 by the above liquid ingredients was judged to be 100%. 0092 An anti-odor test was carried out as follows: 0087. The anhydrous composition comprising 10% L-Glutathione diethyl ester 10 g was dissolved in 90 ml N-acetyl-L-cysteine and 90% liquid ingredient(s) selected, solution prepared from isopropyl alcohol 50 parts, diethyl singly or in combination, from ethyl glycolate, ethyl-L- tartarate 25 parts, and triethyl citrate 25 parts volume by lactate, diethyl tartrate, triethyl citrate, tripropyl citrate, volume. This solution contained 10% L-glutathione diethyl ethyl-DL-mandelate, benzyl N-acetyl-prolinate, ethyl ester in an anhydrous composition, and did not have any N-acetyl-prolinate, propyl N-acetyl-prolinate does not have malodor as judged by the panel. The composition may be malodor, and may be used, for example, in the topical used, for example, in the topical prevention or treatment of prevention or treatment of various cosmetic conditions, various cosmetic conditions, dermatological indications and dermatological indications and other disorders including other disorders including, but not limited to, melasma, age melasma, age spots and wrinkles. spots and wrinkles. EXAMPLE 16 EXAMPLE 21 0088 An anti-odor test was carried out as follows. 0093. An anti-odor test was carried out as follows: N-Acetyl-L-cysteine (MW 163) 10 g was dissolved in N-Acetyl-L-glutathione diethyl ester 10 g was dissolved in 2.2-sulfonyldiethanol 60% in water, 90 g. This liquid com 90 ml solution prepared from isopropyl alcohol 50 parts, position contained 10% N-Acetyl-L-cysteine, 54%. 2.2-sul diethyl tartarate 25 parts, and triethylcitrate 25 parts volume fonyldiethanol and 36% water. This composition did not by volume. This solution contained 10% N-acetyl-L-glu have any malodor as judged by the panel. The composition tathione diethyl ester in an anhydrous composition, and did may be used, for example, in the topical prevention or not have any malodor as judged by the panel. The compo treatment of various cosmetic conditions, dermatological sition may be used, for example, in the topical prevention or indications and other disorders including, but not limited to, treatment of various cosmetic conditions, dermatological melasma, age spots and wrinkles. indications and other disorders including, but not limited to, EXAMPLE 17 melasma, age spots and wrinkles. 0089 An anti-odor test was carried out as follows: N.S.- EXAMPLE 22 Diacetyl-L-cysteine methyl ester 10 g was dissolved in a 90 ml solution prepared from isopropyl alcohol 50 parts, 0094. An anti-odor test was also carried out as follows: diethyl tartarate 25 parts and triethylcitrate 25 parts volume N-Acetyl-L-glutathione diethyl ester 10 g was dissolved in by volume. This solution contained 10% N.S.-diacetyl-L- 90 ml diethyl tartarate. This solution contained 10% cysteine methyl ester in an anhydrous composition, and did N-acetyl-L-glutathione diethyl ester in an anhydrous com not have any malodor as judged by the panel. The compo position, and did not have any malodor as judged by the sition may be used, for example, in the topical prevention or panel. The composition may be used, for example, in the treatment of various cosmetic conditions, dermatological topical prevention or treatment of various cosmetic condi indications and other disorders including, but not limited to, tions, dermatological indications and other disorders includ melasma, age spots and wrinkles. ing, but not limited to, melasma, age spots and wrinkles. EXAMPLE 1.8 EXAMPLE 23 0090 An anti-odor test was carried out as follows: 0095) An anti-odor test was also carried out as follows: N-Propanoyl-L-cysteine 2 g was dissolved in 98 ml solution N.S.-Diacetyl-L-cysteine ethyl ester 10 g was dissolved in 90 US 2006/025 1597 A1 Nov. 9, 2006 ml solution prepared from isopropyl alcohol 50 parts, N-acetyl-L-cysteine and 5% diphenylsulfone in water, and diethyl tartarate 25 parts and triethylcitrate 25 parts volume did not have any malodor as judged by the panel. The by volume. This solution contained 10% N.S.-diacetyl-L- composition may be used, for example, in the topical cysteine ethyl ester in an anhydrous composition, and did prevention or treatment of various cosmetic conditions, not have any malodor as judged by the panel. The compo dermatological indications and other disorders including, sition may be used, for example, in the topical prevention or but not limited to, melasma, age spots and wrinkles. treatment of various cosmetic conditions, dermatological indications and other disorders including, but not limited to, EXAMPLE 30 melasma, age spots and wrinkles. 0102) An anti-odor test was carried out as follows: EXAMPLE 24 N-Acetyl-L-cysteine 10 g and dimethyl sulfone 5 g were dissolved in water 85 ml. This aqueous solution contained 0096. An anti-odor test was carried out as follows: 10% N-acetyl-L-cysteine and 5% dimethyl sulfone, and did N-Acetyl-L-cysteine 10 g and dimethyl sulfone 10 g were not have any malodor as judged by the panel. The compo dissolved in water 80 ml. This aqueous solution contained sition may be used, for example, in the topical prevention or 10% N-acetyl-L-cysteine and 10% dimethylsulfone, and did treatment of various cosmetic conditions, dermatological not have any malodor as judged by the panel. indications and other disorders including, but not limited to, melasma, age spots and wrinkles. EXAMPLE 25 0097. A malodor test was carried out as follows: EXAMPLE 31 N-Acetyl-L-cysteine 10 g and dimethyl sulfone 10 g were 0103) An anti-odor test was carried out as follows: dissolved in ethanol 80 ml. This alcoholic solution contained N-Acetyl-L-cysteine 10g and 4,4'-sulfonyl-bis(methylben 10% N-acetyl-L-cysteine and 10% dimethyl sulfone, and Zoate) 5 g were mixed with water 85 ml. This mixture had a very strong malodoras judged by the panel. This result contained 10% N-acetyl-L-cysteine and 5% 4,4'-sulfonyl shows that ethanol may enhance the malodor produced by bis(methylbenzoate), and did not have any malodor as N-acetyl-L-cysteine. judged by the panel. The composition may be used, for example, in the topical prevention or treatment of various EXAMPLE 26 cosmetic conditions, dermatological indications and other 0098. An anti-odor test was carried out as follows: disorders including, but not limited to, melasma, age spots N-Acetyl-L-cysteine 10 g was dissolved in water 80 ml and wrinkles containing dapsone 10 g. This aqueous mixture contained 10% N-acetyl-L-cysteine and 10% dapsone, and did not EXAMPLE 32 have any malodor as judged by the panel. The composition 0104. An anti-odor test was carried out as follows: may be used, for example, in the topical prevention or N-Acetyl-L-cysteine 10 g and 4,4'-sulfonyl-bis(2-meth treatment of various cosmetic conditions, dermatological ylphenol) 5 g were mixed with water 85 ml. This mixture indications and other disorders including, but not limited to, contained 10% N-acetyl-L-cysteine and 5% 4,4'-sulfonyl melasma, age spots and wrinkles. bis(2-methylphenol), and did not have any malodor as judged by the panel. The composition may be used, for EXAMPLE 27 example, in the topical prevention or treatment of various 0099. A malodor test was carried out as follows: cosmetic conditions, dermatological indications and other N-Acetyl-L-cysteine 10 g and dapsone 10 g were dissolved disorders including, but not limited to, melasma, age spots in ethanol 40 ml and propylene glycol 40 ml. This solution and wrinkles. contained 10% N-acetyl-L-cysteine and 10% dapsone in ethanol and propylene glycol, and had a very strong malodor EXAMPLE 33 as judged by the panel. This result shows that ethanol and 0105. An anti-odor test was carried out as follows: propylene glycol may enhance the malodor produced by N-Acetyl-L-cysteine 10g and 2,2'-sulfonyldiethaol 60-65% N-acetyl-L-cysteine. by weight in water 8 g were dissolved in water 82 ml. This aqueous solution contained 10% N-acetyl-L-cysteine and EXAMPLE 28 5%. 2,2'-sulfonyldiethaol, and did not have any malodor as 0100. An anti-odor test was carried out as follows: judged by the panel. The composition may be used, for N-Acetyl-L-cysteine 10g and dapsone 5 g were mixed with example, in the topical prevention or treatment of various water 85 ml. This mixture contained 10% N-acetyl-L- cosmetic conditions, dermatological indications and other cysteine and 5% dapsone in water, and did not have any disorders including, but not limited to, melasma, age spots malodor as judged by the panel. The composition may be and wrinkles. used, for example, in the topical prevention or treatment of various cosmetic conditions, dermatological indications and EXAMPLE 34 other disorders including, but not limited to, melasma, age 0106 An anti-odor test was carried out as follows: spots and wrinkles. N-Acetyl-L-cysteine, 10 g and ethyl acetoacetate 5 g were mixed with water 85 ml. This mixture contained 10% EXAMPLE 29 N-acetyl-L-cysteine and 5% ethyl acetoacetate, and did not 0101. An anti-odor test was carried out as follows: have any malodor as judged by the panel. The composition N-Acetyl-L-cysteine, 10 g and diphenylsulfone 5 g were may be used, for example, in the topical prevention or mixed with water 85 ml. This mixture contained 10% treatment of various cosmetic conditions, dermatological US 2006/025 1597 A1 Nov. 9, 2006

indications and other disorders including, but not limited to, bis(2-methylphenol): 4,4'-sulfonyldiphenol. 2,2'-sulfonyldi melasma, age spots and wrinkles. ethanol, and any combination thereof. 9. The composition of claim 2, wherein the anti-odor EXAMPLE 35 ingredient is an organic amine. 0107 N-Acetyl-L-cysteine 10 g and 4,4'-sulfonyldiphe 10. The composition of claim 9, wherein the organic nol 5 g were dissolved in propylene glycol 10 ml and the amine is a heterocyclic amine. solution thus obtained was mixed with hydrophilic ointment 11. The composition of claim 9, wherein the organic or oil-in-water emulsion 5 g. The cream thus prepared amine is selected from the group consisting of adenine, contained 10% N-acetyl-L-cysteine and 5% 4,4'-sulfonyl amantadine (1-adamantanamine), 2-adamantylamine, diphenol, and the composition did not have any malodor as adenosine, agnatine, agroclavine, 1-(2-aminoethyl)pipera judged by the panel. This result shows that 4,4'-sulfonyl Zine, 5-amino-4-imidazolecarboxamide, 2-aminoimidazole, diphenol can completely eliminate or prevent the malodor 2-amino-2-methyl-1-propanol, 2-aminoperimidine, 3-ami produced by N-acetyl-L-cysteine in a cream or oil-in-water noquinuclidine, 4-amino-2.2.6,6-tetramethylpiperidine, emulsion. The composition may be used, for example, in the 5-aminotetrazole, benzoctamine, benztropine, 1-benzylpip topical prevention or treatment of various cosmetic condi erazine; 4.4-bipiperidine chlorhexidine, cocamine, creati tions, dermatological indications and other disorders includ nine, cytidine, cytosine, dicocamine, diethanolamine, diiso ing, but not limited to, melasma, age spots and wrinkles. propanolamine, dimethyl behenamine, dimethyl cocamine, edamine, glucamine, guanine, guanosine, meglumine 0108) While the invention has been described with ref (N-methylglucamine), memantine, methenamine, morpho erence to particularly preferred embodiments and examples, line, oleamine, piperazine, porphine, quinuclidine, 3-quinu those skilled in the art recognize that various modifications clidinol, quinupramine, rimantadine, Soyamine, soyamino may be made to the invention without departing from the propylamine, triethylenediamine, trizma base spirit and scope thereof. tris(hydroxymethyl)aminomethane), tropane, tromanta What is claimed is: dine, tromethamine (2-amino-2-hydroxymethyl-1,3-pro 1. A composition comprising a malodor compound and an panediol), tropine, tropinone, and any combination thereof. anti-odor ingredient, wherein the anti-odor ingredient is 12. The composition of claim 9, wherein the organic effective in reducing the presence or production of malodor. amine is selected from the group consisting of amantadine, 2. The composition of claim 1, wherein the malodor 1-(2-aminoethyl)piperazine, chlorhexidine, glucamine, compound is selected from the group consisting of an meglumine (N-methylglucamine), memantine, meth organic mercaptan, organic thiol, organic dithiol, and any enamine, piperazine, porphine, quinuclidine, 3-quinuclidi combination thereof. nol, quinupramine, rimantadine, triethylenediamine, tro 3. The composition of claim 2, wherein the composition pane, tromantadine, tropine, tropinone, and any combination has a pH from about 3 to about 6. thereof. 4. The composition of claim 2, wherein the organic thiol 13. The composition of claim 1, wherein the composition is selected from the group consisting of glyceryl monomer is an anhydrous composition and wherein the anti-odor captan, thioglycolic acid, cysteine, cysteine esters, N-acetyl ingredient is present at a concentration of about 1% or higher cysteine, N-acetyl-cysteine esters; N.S.-diacetyl-cysteine concentration by weight of the total composition. esters, glutathione, glutathione esters, N-acetyl-glutathione, 14. The composition of claim 13, wherein the anti-odor N-acetyl-glutathione esters, methionine, ammonium ingredient is selected from the group consisting of alpha thioglycolate, calcium thioglycolate, Zinc thioglycolate, hydroxyacid esters, N-acetylamino acid esters, and any potassiumm thioglycolate, monoethanolammonium thiogly combination thereof. colate, mercaptopurine, lipoic acid, 6,8-dimercaptooctanoic 15. The composition of claim 13, wherein the anti-odor acid (dihydrolipoic acid), and any combination thereof. ingredient is selected from the group consisting of methyl 5. The composition of claim 2, wherein organic thiol is glycolate, methyl lactate, methyl 2-methylactate, methyl N-acetyl-L-cysteine. 2-hydroxybutanoate, methyl 2-hydroxypentanoate, methyl 6. The composition of claim 2, wherein the anti-odor 2-hydroxyhexanoate, methyl 2-hydroxyheptanoate, methyl ingredient is a Sulfone. 2-hydroxyoctanoate, methyl 2-hydroxyeicosanoate, methyl 7. The composition of claim 6, wherein the sulfone is cerebronate, methyl 2-hydroxynervonate, methyl mandelate, represented by the generic structure of methyl benzilate, methyl 3-phenylactate, methyl atrolac tate, dimethyl malate, dimethyl tartarate, trimethyl citrate, RSO R2 trimethyl isocitrate, methyl 3-hydroxypropanoate, methyl where R and R are independently NH NHCONH2, 3-hydroxybutanoate, methyl 3-hydroxypentanoate, methyl NHC(=NH)NH, an alkyl, aralkyl or aryl group hav tropate, ethyl glycolate, ethyl lactate, ethyl 2-methylactate, ing 1 to 14 carbon atoms, and R and R may also carry ethyl 2-hydroxybutanoate, ethyl 2-hydroxypentanoate, ethyl OH, NH, CONH, COOR, NHCONH, 2-hydroxyhexanoate, ethyl 2-hydroxyheptanoate, ethyl NHC(=NH)NH, imidazole, pyrrolidine or other het 2-hydroxyoctanoate, ethyl 2-hydroxyeicosanoate, ethyl erocyclic group; R is H, an alkyl, aralkyl or aryl group cerebronate, ethyl 2-hydroxynervonate, ethyl mandelate, having 1 to 9 carbon atoms; and the H attached to any ethyl benzilate, ethyl 3-phenylactate, ethyl atrolactate, carbon atom may be substituted by I, F, Cl, Br, OH or diethyl malate, diethyl tartarate, triethyl citrate, triethyl alkoxy group having 1 to 9 carbon atoms. isocitrate, ethyl 3-hydroxypropanoate, ethyl 3-hydroxybu 8. The composition of claim 6, wherein the sulfone is tanoate, ethyl 3-hydroxypentanoate, ethyl tropate, propyl selected from the group consisting of dimethyl Sulfone, glycolate, propyl lactate, propyl 2-methylactate, propyl diethyl sulfone, diphenyl sulfone, methyl phenyl sulfone, 2-hydroxybutanoate, propyl 2-hydroxypentanoate, propyl dapsone; 4,4'-sulfonylbis(methylbenzoate); 4,4'-sulfonyl 2-hydroxyhexanoate, propyl 2-hydroxyheptanoate, propyl US 2006/025 1597 A1 Nov. 9, 2006

2-hydroxyoctanoate, propyl 2-hydroxyeicosanoate, propyl nate, diisopropyl N-acetyl-aspartate, isopropyl N-acetyl cerebronate, propyl 2-hydroxynervonate, propyl mandelate, glycinate, diisopropyl N-acetyl-glutamate, isopropyl propylbenzilate, propyl 3-phenylactate, propyl atrolactate, N-acetyl-glutaminate, isopropyl N-acetyl-histidinate, iso dipropyl malate, dipropyl tartarate, tripropyl citrate, tripro propyl N-acetyl-isoleucinate, isopropyl N-acetyl-leucinate, pyl isocitrate, propyl 3-hydroxypropanoate, propyl 3-hy isopropyl N-acetyl-lysinate, isopropyl N-acetyl-phenyla droxybutanoate, propyl 3-hydroxypentanoate, propyl tro laninate, isopropyl N-acetyl-prolinate, isopropyl N-acetyl pate, isopropyl lactate, isopropyl 2-methylactate, isopropyl serinate, isopropyl N-acetyl-threoninate, isopropyl 2-hydroxybutanoate, isopropyl 2-hydroxypentanoate, iso N-acetyl-tryptophanate, isopropyl N-acetyl-tyrosinate, iso propyl 2-hydroxyhexanoate, isopropyl 2-hydroxyhep propyl N-acetyl-valinate, isopropyl N-acetyl-3-alaninate, tanoate, isopropyl 2-hydroxyoctanoate, isopropyl 2-hydrox isopropyl N-acetyl-y-aminobutanoate, isopropyl N-acetyl-3- yeicosanoate, isopropyl cerebronate, isopropyl aminoisobutanoate, isopropyl N-acetyl-citrullinate, isopro 2-hydroxynervonate, isopropyl mandelate, isopropylbenzi pyl N-acetyl-homoserinate, isopropyl N-acetyl-ornithinate, late, isopropyl 3-phenylactate, isopropyl atrolactate, diiso isopropyl N-acetyl-phenylglycinate, isopropyl N-acetyl-4- propyl malate, diisopropyl tartarate, triisopropyl citrate, hydroxyphenylglycinate, isopropyl N.O-diacetyl-4-hydrox triisopropyl isocitrate, isopropyl 3-hydroxypropanoate, iso yphenylglycinate, and any combination thereof. propyl 3-hydroxybutanoate, isopropyl 3-hydroxypen 17. The composition of claim 13, wherein the anti-odor ingredient is selected from the group consisting of butoxy tanoate, isopropyl tropate, and any combination thereof. diglycol, butoxyethanol, butoxypropanol, butyl acetate, 16. The composition of claim 13, wherein the anti-odor ingredient is selected from the group consisting of methyl butanol, butyloctanol, cycloethoxymethicone, cyclohexane, N-acetyl-alaninate, methyl N-acetyl-argininate, methyl cyclomethicone, dibutyl adipate, diisobutyl adipate, diiso N-acetyl-asparaginate, dimethyl N-acetyl-aspartate, methyl propyl adipate, diisopropyl oxalate, diisopropyl sebacate, N-acetyl-glycinate, dimethyl N-acetyl-glutamate, methyl dimethicone, dimethoxydiglycol, dimethyl adipate, dim N-acetyl-glutaminate, methyl N-acetyl-histidinate, methyl ethyl glutarate, dioctyl adipate, dioctyl sebacate, dioctyl N-acetyl-isoleucinate, methyl N-acetyl-leucinate, methyl Succinate, dipropyl adipate, dipropylene glycol, ethoxydig N-acetyl-lysinate, methyl N-acetyl-phenylalaninate, methyl lycol, ethoxyethanol, 2-ethyl-1,3-hexanediol, isododecane, N-acetyl-prolinate, methyl N-acetyl-serinate, methyl isooctane, isoparaffin, isopropyl acetate, isopropyl alcohol, N-acetyl-threoninate, methyl N-acetyl-tryptophanate, isopropyl myristate, isopropyl palmitate, methicone, octa methyl N-acetyl-tyrosinate, methyl N-acetyl-valinate, decane, octanol, octylbenzoate, oleyl alcohol, oleyl lactate, methyl N-acetyl-3-alaninate, methyl N-acetyl-y-aminobu PEG, phenyl methicone, n-propanol, ethyl acetoacetate, tanoate, methyl N-acetyl-3-aminoisobutanoate, methyl methyl acetoacetate, propyl acetoacetate, isopropyl acetoac N-acetyl-citrullinate, methyl N-acetyl-homoserinate, methyl etate, silicone oil, and any combination thereof. N-acetyl-ornithinate, methyl N-acetyl-phenylglycinate, 18. The composition of claim 2, where the composition is methyl N-acetyl-4-hydroxyphenylglycinate, methyl N.O-di formulated for topical administration to a subject. acetyl-4-hydroxyphenylglycinate, ethyl N-acetyl-alaninate, 19. The composition of claim 18, wherein the composi ethyl N-acetyl-argininate, ethyl N-acetyl-asparaginate, tion further comprises at least one additional ingredient, diethyl N-acetyl-aspartate, ethyl N-acetyl-glycinate, diethyl wherein the additional ingredient is a cosmetic or pharma N-acetyl-glutamate, ethyl N-acetyl-glutaminate, ethyl ceutically active agent. N-acetyl-histidinate, ethyl N-acetyl-isoleucinate, ethyl 20. A method of reducing the presence or production of N-acetyl-leucinate, ethyl N-acetyl-lysinate, ethyl N-acetyl malodor from a malodor compound comprising topically phenylalaninate, ethyl N-acetyl-prolinate, ethyl N-acetyl administering to a subject a malodor compound and an serinate, ethyl N-acetyl-threoninate, ethyl N-acetyl-tryp anti-odor ingredient, wherein the anti-odor ingredient is tophanate, ethyl N-acetyl-tyrosinate, ethyl N-acetyl effective in reducing the presence or production of malodor, valinate, ethyl N-acetyl-f-alaninate, ethyl N-acetyl-y- wherein the malodor compound is selected from the group aminobutanoate, ethyl N-acetyl-3-aminoisobutanoate, ethyl consisting of an organic mercaptan, organic thiol, organic N-acetyl-citrullinate, ethyl N-acetyl-homoserinate, ethyl dithiol, and any combination thereof. N-acetyl-ornithinate, ethyl N-acetyl-phenylglycinate, ethyl 21. The method of claim 20, wherein organic thiol com N-acetyl-4-hydroxyphenylglycinate, ethyl N, O-diacetyl-4- pound is N-acetyl-L-cysteine. hydroxyphenylglycinate, propyl N-acetyl-alaninate, propyl 22. The method of claim 20, wherein the anti-odor ingre N-acetyl-argininate, propyl N-acetyl-asparaginate, dipropyl dient is a Sulfone. N-acetyl-aspartate, propyl N-acetyl-glycinate, dipropyl 23. The method of claim 20, wherein the anti-odor ingre N-acetyl-glutamate, propyl N-acetyl-glutaminate, propyl dient is an organic amine selected from the group consisting N-acetyl-histidinate, propyl N-acetyl-isoleucinate, propyl of adenine, amantadine (1-adamantanamine), 2-adamanty N-acetyl-leucinate, propyl N-acetyl-lysinate, propyl lamine, adenosine, agmatine, agroclavine, 1-(2-aminoeth N-acetyl-phenylalaninate, propyl N-acetyl-prolinate, propyl yl)piperazine, 5-amino-4-imidazolecarboxamide, 2-ami N-acetyl-serinate, propyl N-acetyl-threoninate, propyl noimidazole, 2-amino-2-methyl-1-propanol, N-acetyl-tryptophanate, propyl N-acetyl-tyrosinate, propyl 2-aminoperimidine, 3-aminoquinuclidine, 4-amino-2,2.6.6- N-acetyl-valinate, propyl N-acetyl-3-alaninate, propyl tetramethylpiperidine, 5-aminotetrazole, benzoctamine, N-acetyl-y-aminobutanoate, propyl N-acetyl-3-aminoisobu benztropine, 1-benzylpiperazine; 4.4-bipiperidine chlo tanoate, propyl N-acetyl-citrullinate, propyl N-acetyl-ho rhexidine, cocamine, creatinine, cytidine, cytosine, dico moserinate, propyl N-acetyl-ornithinate, propyl N-acetyl camine, diethanolamine, diisopropanolamine, dimethyl phenylglycinate, propyl N-acetyl-4- behenamine, dimethyl cocamine, edamine, glucamine, gua hydroxyphenylglycinate, propyl N.O-diacetyl-4- nine, guanosine, meglumine (N-methylglucamine), meman hydroxyphenylglycinate, isopropyl N-acetyl-alaninate, tine, methenamine, morpholine, oleamine, piperazine, por isopropyl N-acetyl-argininate, isopropyl N-acetyl-asparagi phine, quinuclidine, 3-quinuclidinol, quinupramine, US 2006/025 1597 A1 Nov. 9, 2006 rimantadine, Soyamine, soyaminopropylamine, triethylene conditions, dermatological indications, and thiol compound diamine, trizma base tris(hydroxymethyl)aminomethane). responsive indications. tropane, tromantadine, tromethamine (2-amino-2-hy 28. The claim of 27, wherein the conditions and indica droxymethyl-1,3-propanediol), tropine, tropinone, and any tions are selected from the group consisting of deranged or combination thereof. disordered cutaneous tissues relevant to skin, nail and hair; 24. A method of reducing the presence or production of oral, vaginal and anal mucosa; promotion of wound healing; malodor from a malodor compound comprising topically disturbed keratinization; inflammation; and changes associ administering to a subject an anhydrous composition com ated with intrinsic and extrinsic aging; acne, age spots; prising a malodor compound and an anti-odor ingredient; blemished skin; blotches; cellulite; dermatoses; dandruff; wherein the anti-odor ingredient is effective in reducing the dry skin; eczema, elastosis; herpes; hyperkeratosis; hyper presence or production of malodor; wherein the malodor pigmented skin; severe dry skin, ichthyosis; keratoses; len compound is selected from the group consisting of an tigines; melasmas; mottled skin; pseudofolliculitis barbae; organic mercaptan, organic thiol, and organic dithiol; and photoaging and photodamage; pruritus; psoriasis; skin lines; wherein the anti-odor ingredient is present at a concentration stretch marks; thinning of skin, nail plate and hair, warts; of about 1% or higher concentration by weight of the total wrinkles: Xerosis; oral or gum disease; irritated, inflamed, composition. unhealthy, damaged or abnormal mucosa, skin, hair, nail, 25. The method of claim 24, wherein the anti-odor ingre nostril, ear canal, anal or vaginal conditions; defective dient is selected from the group consisting of alpha-hy synthesis or repair of dermal components; abnormal or droxyacid esters, N-acetylamino acid esters, and any com diminished synthesis of collagen, glycosaminoglycans, pro bination thereof. teoglycans and elastin as well as diminished levels of Such 26. The method of claim 24, wherein the anti-odor ingre components in the dermis; uneven and rough Surface of skin, dient is selected from the group consisting of butoxydigly nail and hair, loss or reduction of skin, nail and hair col, butoxyethanol, butoxypropanol, butyl acetate, butanol, resiliency, elasticity and recoilability; lack of skin, nail and butyloctanol, cycloethoxymethicone, cyclohexane, cyclom hair lubricants and luster, fragility and splitting of nail and ethicone, dibutyl adipate, diisobutyl adipate, diisopropyl hair, yellowing skin; reactive, irritating or telangiectatic adipate, diisopropyl oxalate, diisopropyl sebacate, dimethi skin; dull and older-looking skin, nail and hair; for skin cone, dimethoxydiglycol, dimethyl adipate, dimethyl glut bleach and lightening and wound healing, for plumping the arate, dioctyl adipate, dioctyl sebacate, dioctyl Succinate, skin; for increasing skin thickness by Stimulating biosyn dipropyl adipate, dipropylene glycol, ethoxydiglycol, thesis of collagen and glycosaminoglycans; and any com ethoxyethanol, 2-ethyl-1,3-hexanediol, isododecane, isooc bination thereof. tane, isoparaffin, isopropyl acetate, isopropyl alcohol, iso 29. The composition of claim 28, wherein the organic propyl myristate, isopropyl palmitate, methicone, octade thiol is selected from the group consisting of N-acetyl cane, octanol, octyl benzoate, oleyl alcohol, oleyl lactate, cysteine, N.S.-diacetyl-cysteine esters, glutathione, glu PEG, phenyl methicone, n-propanol, ethyl acetoacetate, tathione esters, N-acetyl-glutathione, N-acetyl-glutathione methyl acetoacetate, propyl acetoacetate, isopropyl acetoac esters, lipoic acid, 6,8-dimercaptooctanoic acid (dihydroli etate, silicone oil, and any combination thereof. poic acid), and any combination thereof. 27. The composition of claim 2, wherein the composition is formulated for topical administration to improve cosmetic k k k k k