DOCSLIB.ORG

B COUNCIL REGULATION (EU) No 1387/2013 of 17

Total Page：16

File Type：pdf, Size：1020Kb

Download full-text PDF Read full-text
B COUNCIL REGULATION (EU) No 1387/2013 of 17 02013R1387 — EN — 01.01.2019 — 010.001 — 1 This text is meant purely as a documentation tool and has no legal effect. The Union's institutions do not assume any liability for its contents. The authentic versions of the relevant acts, including their preambles, are those published in the Official Journal of the European Union and available in EUR-Lex. Those official texts are directly accessible through the links embedded in this document ►B COUNCIL REGULATION (EU) No 1387/2013 of 17 December 2013 suspending the autonomous Common Customs Tariff duties on certain agricultural and industrial products and repealing Regulation (EU) No 1344/2011 (OJ L 354, 28.12.2013, p. 201) Amended by: Official Journal No page date ►M1 Council Regulation (EU) No 722/2014 of 24 June 2014 L 192 9 1.7.2014 ►M2 Council Regulation (EU) No 1341/2014 of 15 December 2014 L 363 10 18.12.2014 ►M3 Council Regulation (EU) 2015/982 of 23 June 2015 L 159 5 25.6.2015 ►M4 Council Regulation (EU) 2015/2449 of 14 December 2015 L 345 11 30.12.2015 ►M5 Council Regulation (EU) 2016/1051 of 24 June 2016 L 173 5 30.6.2016 ►M6 Council Regulation (EU) 2016/2390 of 19 December 2016 L 360 14 30.12.2016 ►M7 Council Regulation (EU) 2017/1134 of 20 June 2017 L 164 6 27.6.2017 ►M8 Council Regulation (EU) 2017/2467 of 21 December 2017 L 351 7 30.12.2017 ►M9 Council Regulation (EU) 2018/914 of 25 June 2018 L 162 8 27.6.2018 ►M10 Council Regulation (EU) 2018/2069 of 20 December 2018 L 331 4 28.12.2018 Corrected by: ►C1 Corrigendum, OJ L 293, 9.10.2014, p. 57 (1387/2013) ►C2 Corrigendum, OJ L 293, 9.10.2014, p. 58 (722/2014) 02013R1387 — EN — 01.01.2019 — 010.001 — 2 ▼B COUNCIL REGULATION (EU) No 1387/2013 of 17 December 2013 suspending the autonomous Common Customs Tariff duties on certain agricultural and industrial products and repealing Regulation (EU) No 1344/2011 ▼M3 Article 1 1. The autonomous Common Customs Tariff duties for the agricultural and industrial products listed in ►M4 the Annex ◄ are hereby suspended. 2. Paragraph 1 does not apply to any mixtures, preparations or products made up of different components containing products listed in ►M4 the Annex ◄. ▼B Article 2 1. The Commission may at any time review the suspensions for the products listed in ►M4 the Annex ◄ in the following cases: (a) at its own initiative; (b) at the request of Member States. ▼M4 2. The Commission shall review the suspensions for products listed in the Annex during the year preceding the end date for mandatory review provided for in that Annex. Article 3 Where a declaration for release for free circulation is presented for the products in relation to which the supplementary units have been provided in the Annex, the exact quantity of the products imported shall be entered in ‘Box 41: Supplementary units’ of that declaration using the measurement unit set out in the Annex. ▼B Article 4 Regulation (EU) No 1344/2011 is hereby repealed. Article 5 This Regulation shall enter into force on the day of its publication in the Official Journal of the European Union. It shall apply from 1 January 2014. This Regulation shall be binding in its entirety and directly applicable in all Member States. 02013R1387 — EN — 01.01.2019 — 010.001 — 3 ▼M10 ANNEX Rate of Supple­ Date foreseen CN code TARIC Description autonomo­ mentary for mandatory us duty unit review ex 0709 59 10 10 Fresh or chilled chanterelles for treatment other than 0 % — 31.12.2020 simple repacking for retail sale (1 ) (2 ) *ex 0710 21 00 10 Peas in pods, of the species Pisum sativum of the 0 % — 31.12.2023 variety Hortense axiphium, frozen, of a thickness of not more than 6 mm, to be used, in their pods, in the manufacture of prepared meals (1 ) (2 ) *ex 0710 80 95 50 Bamboo shoots, frozen, not put up for retail sale 0 % — 31.12.2023 ex 0711 59 00 11 Mushrooms, excluding mushrooms of the genera 0 % — 31.12.2021 Agaricus, Calocybe, Clitocybe, Lepista, Leuco­ agaricus, Leucopaxillus, Lyophyllum and Tricholoma, provisionally preserved in brine, in sulphur water, or in other preservative solutions, but unsuitable in that state for immediate consumption, for the food-canning industry (2 ) *ex 0712 32 00 10 Mushrooms, excluding mushrooms of the genus 0 % — 31.12.2023 Agaricus, dried, whole or in identifiable slices or ex 0712 33 00 10 pieces, for treatment other than simple repacking ex 0712 39 00 31 for retail sale (1 ) (2 ) *ex 0804 10 00 30 Dates, fresh or dried, for use in the manufacture 0 % — 31.12.2023 (excluding packing) of products of drink or food industries (2 ) *0811 90 50 Fruit of the genus Vaccinium, uncooked or cooked 0 % — 31.12.2023 by steaming or boiling in water, frozen, not 0811 90 70 containing added sugar or other sweetening matter ex 0811 90 95 70 *ex 0811 90 95 20 Boysenberries, frozen, not containing added sugar, 0 % — 31.12.2023 not put up for retail sale *ex 0811 90 95 30 Pineapple (Ananas comosus), in pieces, frozen 0 % — 31.12.2023 *ex 0811 90 95 40 Rose-hips, uncooked or cooked by steaming or 0 % — 31.12.2023 boiling in water, frozen, not containing added sugar or other sweetening matter *ex 1511 90 19 20 Palm oil, coconut (copra) oil, palm kernel oil, for the 0 % — 31.12.2019 manufacture of: ex 1511 90 91 20 — industrial monocarboxylic fatty acids of ex 1513 11 10 20 subheading 3823 19 10, ex 1513 19 30 20 — methyl esters of fatty acids of heading 2915 or ex 1513 21 10 20 2916, ex 1513 29 30 20 — fatty alcohols of subheadings 2905 17, 2905 19 and 3823 70 used for the manufacture of cosmetics, washing products or pharmaceutical products, 02013R1387 — EN — 01.01.2019 — 010.001 — 4 ▼M10 Rate of Supple­ Date foreseen CN code TARIC Description autonomo­ mentary for mandatory us duty unit review — fatty alcohols of subheading 2905 16, pure or mixed, used for the manufacture of cosmetics, washing products or pharmaceutical products, — stearic acid of subheading 3823 11 00, — goods of heading 3401, or — fatty acids with high purity of heading 2915 (2 ) ex 1512 19 10 10 Refined safflower oil (CAS RN 8001-23-8) for use in 0 % — 31.12.2020 the manufacture of: — conjugated linoleic acid of heading 3823, or — ethyl- or methyl esters of linoleic acid of heading 2916 (2 ) *ex 1515 90 99 92 Vegetable oil, refined, containing by weight 35 % or 0 % — 31.12.2023 more but not more than 50 % of arachidonic acid or 35 % or more but not more than 50 % of docosa­ hexaenoic acid ex 1516 20 96 20 Jojoba oil, hydrogenated and interesterified, without 0 % — 31.12.2019 any further chemical modification and not subjected to any texturisation process ex 1517 90 99 10 Vegetable oil, refined, containing by weight 25 % or 0 % — 31.12.2021 more but not more than 50 % arachidonic acid or 12 % or more but not more than 65 % docosahex­ aenoic acid and standardized with high oleic sunflower oil (HOSO) *ex 1901 90 99 39 Preparation in powder form containing by weight: 0 % — 31.12.2023 ex 2106 90 98 45 — 15 % or more but not more than 35 % of wheat derived Maltodextrin, — 15 % or more but not more than 35 % of whey (milk serum), — 10 % or more but not more than 30 % of refined, bleached, deodorised and non-hydrogenated sunflower oil, — 10 % or more but not more than 30 % of blended, aged spray dried cheese, — 5 % or more but not more than 15 % of buttermilk, and — 0,1 % or more but not more than 10 % of sodium caseinate, disodium phosphate, lactic acid *ex 1902 30 10 10 Transparent noodles, cut in pieces, obtained from 0 % — 31.12.2023 beans (Vigna radiata (L.) Wilczek), not put up for ex 1903 00 00 20 retail sale 02013R1387 — EN — 01.01.2019 — 010.001 — 5 ▼M10 Rate of Supple­ Date foreseen CN code TARIC Description autonomo­ mentary for mandatory us duty unit review *ex 2005 91 00 10 Bamboo shoots, prepared or preserved, in immediate 0 % — 31.12.2023 packings of a net content of more than 5 kg ex 2007 99 50 83 Mango puree concentrate, obtained by cooking: 6 % (3 ) — 31.12.2022 ex 2007 99 50 93 — of the Genus Mangifera spp., ex 2007 99 93 10 — with a sugar content by weight of not more than 30 %, for use in the manufacture of products of food and drink industry (2 ) ex 2007 99 50 84 Papaya puree concentrate, obtained by cooking: 7,8 % (3 ) — 31.12.2022 ex 2007 99 50 94 — of the Genus Carica spp., — with a sugar content by weight of more than 13 % but not more than 30 %, for use in the manufacture of products of food and drink industry (2 ) ex 2007 99 50 85 Guava puree concentrate, obtained by cooking: 6 % (3 ) — 31.12.2022 ex 2007 99 50 95 — of the Genus Psidium spp., — with a sugar content by weight of more than 13 % but not more than 30 %, for use in the manufacture of products of food and drink industry (2 ) ex 2008 93 91 20 Sweetened dried cranberries, excluding packing alone 0 % — 31.12.2022 as processing, for the manufacture of products of food processing industries (4 ) ex 2008 99 48 94 Mango puree: 6 % — 31.12.2020 — not from concentrate, — of the genus Mangifera, — of a Brix value of 14 or more, but not more than 20, used in the manufacture of products of drink industry (2 ) ex 2008 99 49 30 Seedless boysenberry puree not containing added 0 % — 31.12.2019 spirit, whether or not containing added sugar ex 2008 99 99 40 ex 2008 99 49 70 Blanched vine leaves of the genus Karakishmish, in 0 % — 31.12.2022 brine, containing by weight: ex 2008 99 99 11 — more than 6 % of salt concentration, — 0,1 % or more but not more than 1,4 % of acidity expressed as citric acid monohydrate, and — whether or not but not more than 2 000 mg/kg of sodium benzoate according CODEX STAN 192- 1995, for use in the manufacture of stuffed vine leaves with rice (2 ) 02013R1387
Load more

Recommended publications
  • Information to Users
    Raman spectroscopic studies of calcium-phosphate, aluminum metaphosphate-sodium fluoride and calcium metaphosphate-calcium fluoride glasses Item Type text; Thesis-Reproduction (electronic) Authors Latifzadeh, Lida, 1956- Publisher The University of Arizona. Rights Copyright © is held by the author. Digital access to this material is made possible by the University Libraries, University of Arizona. Further transmission, reproduction or presentation (such as public display or performance) of protected items is prohibited except with permission of the author. Download date 27/09/2021 07:48:35 Link to Item http://hdl.handle.net/10150/278549 INFORMATION TO USERS The most advanced technology has been used to photograph and reproduce this manuscript from the microfilm master. UMI films the text directly from the original or copy submitted. Thus, some thesis and dissertation copies are in typewriter face, while others may be from any type of computer printer. The quality of this reproduction is dependent upon the quality of the copy submitted. Broken or indistinct print, colored or poor quality illustrations and photographs, print bleedthrough, substandard margins, and improper alignment can adversely affect reproduction. In the unlikely event that the author did not send UMI a complete manuscript and there are missing pages, these will be noted. Also, if unauthorized copyright material had to be removed, a note will indicate the deletion. Oversize materials (e.g., maps, drawings, charts) are reproduced by sectioning the original, beginning at the upper left-hand corner and continuing from left to right in equal sections with small overlaps. Each original is also photographed in one exposure and is included in reduced form at the back of the book.
    [Show full text]
  • 2020-29037.Pdf
    This document is scheduled to be published in the Federal Register on 01/19/2021 and available online at federalregister.gov/d/2020-29037,BILLING and on govinfo.gov CODE 3510-33-P DEPARTMENT OF COMMERCE Bureau of Industry and Security 15 CFR Parts 734, 738, 740, 742, 748, 750, 772, 774 [Docket No. 201221-0350] RIN 0694-AI33 Implementation in the Export Administration Regulations of the United States’ Rescission of Sudan’s Designation as a State Sponsor of Terrorism AGENCY: Bureau of Industry and Security, Commerce. ACTION: Final rule. SUMMARY: In this final rule, the Bureau of Industry and Security (BIS) amends the Export Administration Regulations (EAR) to implement the rescission of Sudan’s designation as a State Sponsor of Terrorism (SSOT). The Secretary of State rescinded this designation effective December 14, 2020 in accordance with established statutory procedures, including the President’s October 26, 2020 submission to Congress of a report justifying the rescission and certifying Sudan had not provided any support for acts of international terrorism during the preceding six month period and that Sudan had provided assurances that it would not support acts of international terrorism in the future. Accordingly, BIS amends the EAR by removing Anti-Terrorism (AT) controls on the country and by removing Sudan from Country Group E:1 (Terrorist supporting countries). These actions render the country eligible for a general 25 percent de minimis level. As a consequence of these actions, as well as the addition of the country to Country Group B, Sudan is also potentially eligible for several new license exceptions under the EAR.
    [Show full text]
  • Development of Novel Peptide Nucleic Acids A
    b-Dicarbonyl compounds Compounds having two carbonyl groups separated by an intervening carbon atom are called b-dicarbonyl compounds, and these compounds are highly versatile reagents for organic synthesis. O O O O C C C R C C C OR' b b b-Dicarbonyl system b-Keto ester ** The pKa for such a proton is in the range 9-11, acidic enough to be removed easily by an alkoxide base to form an enolate. O O O H O OR C C C C C.. C + HOR H enolate anion pKa = 9-11 .. .. .. .. .. .. O . O . O O . O O C C C .. C C C R C OR' R C OR' R C OR' H H H Resonance structure of the anion of a b-keto ester Synthesis of b-keto ester (Claisen condensation) O O O NaOC H 2 2 5 CH3COC2H5 CH3CC..HCOC2H5 + C2H5OH + Na (removed by distillation) Sodiumacetoacetic ester HCl O O CH3CCH2COC2H5 Ethyl acetoacetate (acetoacetic ester) (76%) O O O O (1) NaOC2H5 R CH C + H CHC R CH2C CHCOC H + C H OH 2 OC2H5 OC2H5 + 2 5 2 5 (2) H3O R R (R may also be H) b-Keto ester Mechanism Step1 .. O O . .. + . OHC H + C H OH R CHC OC2H5 .. 2 5 RC.. H C OC2H5 2 5 H .. O . RCH C OC2H5 Step 2 .. .. .. .. O . O O O . RCH2C + . RCH2C CH C OC2H5 HC C OC2H5 . C H O . OC2H5 R 2 5 .. R .. O . O .. + . OC2H5 RCH2C CH C OC2H5 .. R Step 3 .. .. O . O H O O .
    [Show full text]
  • Lonza's Chemical Network Diketene and HCN Derivatives, Heterocycles
    Lonza’s chemical network Diketene and HCN derivatives, heterocycles and basic chemicals catalog Pharma&Biotech Nutrition Agriculture MaterialsScience PersonalCare Diketene and HCN derivatives, heterocycles and basic chemicals catalog Content About Lonza 3 Introduction 4 Diketene / ketene derivatives 6 Esters 6 Arylides 7 Alkylamides 8 Pyrazolones 9 Dehydroacetic acid 9 Lonzamon monomers 10 Other diketene derivatives 10 HCN derivatives 12 Heterocycles 14 Basic chemicals 16 Others 17 Alphabetical index 18 About Lonza Lonza is the global leader in the production and support of active phar- From 1897 to the present day combining Swiss tradition with global maceutical ingredients both chemically and biotechnologically. Biophar- experience, the company has had an enterprising character, adapting maceuticals are one of the key growth drivers of the pharmaceutical and its offerings and services to the needs of customers and to changing biotechnology industries. technologies. Throughout our history, we have maintained a strong culture of performance, results and dependability that is valued by all Lonza has strong capabilities in large and small molecules, peptides, of our customers. amino acids and niche bioproducts which play an important role in the development of novel medicines and healthcare products. In addition, Lonza’s cracker in Visp is the back bone of a comprehensive fully back- Lonza is a leader in cell-based research, endotoxin detection and cell ward integrated chemical network. Our product portfolio consists of therapy manufacturing. Furthermore, the company is a leading provider HCN- and diketene derivatives as well as basic chemicals which are key of chemical and biotech ingredients to the nutrition, hygiene, preserva- raw materials and intermediates for many sophisticated applications.
    [Show full text]
  • Acetoacetic Ester Synthesis
    Programme: B.Sc. B.ed. (Integrated) Course: ORGANIC CHEMISTRY- III Semester: VI Code: CHE-352 Topic: ETHYLACETOACETATEE Date- 07/04/2020 y Only PPe Dr. Angad Kumar Singh ForF Department of Chemistry, Central University of South Bihar, Gaya (Bihar) Note: These materials are only for classroom teaching purpose at Central University of South Bihar. All the data taken from several books, research articles including Wikipedia. Note: These materials are only for classroom teaching purpose at Central University of South Bihar. All the data taken from several books, research articles including Wikipedia. Ethylacetoacetate The Claisen Condensation between esters containing - hdhydrogens, promotdted byabase such as sodium ethoxy ide, toproduce a !- ketoester. One equiv serves as the nucleophilele (enolate)(eno and the other is OnlyO the electrophile which undergoes additiontion andae elimination. The use of stronger bases, e.g. sodium amide or sodiumsodUse hydride instead of sodium ethoxide, often increases the yield.d. al onal Ethylacetoacetate Note: These materials are only for classroom teaching purpose at Central University of South Bihar. All the data taken from several books, research articles including Wikipedia. Mechanism of the Claisen Condensation The reaction is driven to product by the final deprotonation step. Note: These materials are only for classroom teaching purpose at Central University of South Bihar. All the data taken from several books, research articles including Wikipedia. Mixed Claisen Condensation Like mixed aldol reactions, mixed Claisen condensations are useful if differences in reactivity exist betweenn they two esters as for example when one of the esters has no -hydrogenydrogOnlyO . Examples of such esters are: e Use ers excess Note: These materials are only for classroom teaching purpose at Central University of South Bihar.
    [Show full text]
  • Classification of Chemicals
    Classification of Chemicals Flame & Detonation Arrester Specifications PROTECTOSEAL ® The Protectoseal Company recommends that the National Butadiene would qualify as a Group D material. In each of Electric Code (NEC) Article 500, rankings of various chemi - these cases, the chemicals were primarly listed in a higher cals be used, whenever possible, to determine the suitability category (Group B), because of relatively high pressure read - of a detonation arrester for use with a particular chemical. ings noted in one phase of the standard test procedure con - When no NEC rating of the particular chemical is available, ducted by Underwriters Laboratories. These pressures were the International Electrotechnical Commission (IEC) classifica - of concern when categorizing the chemicals because these tion (Groups IIA, IIB and IIC) is recommended as a secondary NEC groupings are also used as standard indicators for the source of information for determining the suitability of an ar - design strength requirements of electrical boxes, apparatus, rester for its intended service. In general, the IEC Group IIA is etc. that must withstand the pressures generated by an igni - equivalent to the NEC Group D; the IEC Group IIB is equiva - tion within the container. It should be noted that, in each of lent to the NEC Group C; and the IEC Group IIC includes these cases, the test pressures recorded were significantly chemicals in the NEC Groups A and B. In the event of a dis - lower than those commonly encountered when testing a deto - crepancy between the NEC and the IEC ratings, Protectoseal nation arrester for its ability to withstand stable and over - recommends that the NEC groups be referenced.
    [Show full text]
  • Method for Producing Difluorophosphate
    (19) TZZ _T (11) EP 2 826 747 A1 (12) EUROPEAN PATENT APPLICATION published in accordance with Art. 153(4) EPC (43) Date of publication: (51) Int Cl.: 21.01.2015 Bulletin 2015/04 C01B 25/455 (2006.01) (21) Application number: 12871541.4 (86) International application number: PCT/JP2012/057408 (22) Date of filing: 14.03.2012 (87) International publication number: WO 2013/136533 (19.09.2013 Gazette 2013/38) (84) Designated Contracting States: • SHOGAMI, Kazuhiko AL AT BE BG CH CY CZ DE DK EE ES FI FR GB Izumiotsu-shi GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO Osaka 595-0075 (JP) PL PT RO RS SE SI SK SM TR • SATOH, Tomoya Designated Extension States: Izumiotsu-shi BA ME Osaka 595-0075 (JP) (71) Applicant: Stella Chemifa Corporation (74) Representative: Winter, Brandl, Fürniss, Hübner, Osaka-shi, Osaka 541-0047 (JP) Röss, Kaiser, Polte - Partnerschaft mbB Patent- und Rechtsanwaltskanzlei (72) Inventors: Alois-Steinecker-Strasse 22 • NISHIDA,Tetsuo 85354 Freising (DE) Izumiotsu-shi Osaka 595-0075 (JP) (54) METHOD FOR PRODUCING DIFLUOROPHOSPHATE (57) A process for preparing difluorophosphate com- from the difluorophosphoric acid by solid-liquid separa- prising reacting difluorophosphoric acid with at least one tion, the precipitate being precipitated by crystallization salt, as a raw material, selected from a halide salt, a car- operation in the difluorophosphoric acid, and removing bonate, a phosphate, a hydroxide and an oxide of an the difluorophosphoric acid contained in the precipitate alkali metal, an alkaline earth metal or an onium in the by distillation to obtain difluorophosphate.
    [Show full text]
  • Ethyl Acetoacetate (Acetoacetic Ester) (B) Diethyl Molonote (Molonic Ester) the Structure of (A) and (B) Are As
    PRESENTATION OF ENOLATES Dr. Susmita Bajpai Department of Chemistry B.N.D. College, Kanpur ENOLATES The class of compounds which contain a methylene group (–CH2–) directly bonded to the electron withdrawing groups such as –COCH3, –COOC2H5, –CN, are called active methylene compounds. This is so because the –CH2 group in them is acidic and reactive. The two examples are (a) Ethyl acetoacetate (Acetoacetic ester) (b) Diethyl molonote (Molonic ester) The structure of (a) and (b) are as This reaction is known as claisen condensation Ethyl acetoacetate (CH3COOCH2COOC2H5) • It's IUPAC name is ethyl 3-oxobutanoate • Preparation: Ethyl acetoacetate is prepared by heating ethyl acetate with sodium ethoxide in ethanol, followed by acidification. Claisen condensation • It is a condensation reaction in which, two ester molecules condensed to form an alcohol and a b-Keto ester. Therefore ethyl acetoacetate is a b-Keto ester. • Mechanism: The mechanism involves three steps: + • Step-I :- First sodium ethoxide (C2H5O–Na ) breaks into ethoxide ion and sodium ion. This ethoxide ion attacks ethyl acetoacetate to give ethyl alcohol and ester anion. Step -II: Ester anion attacks the carbonyl group of a second molecules of ethyl acetate. • Step-III: Ethoxide ion is eliminated Properties • It is a colourless pleasant smelling liquid • b.p. - 180.4oC • It is sparingly soluble in water but freely so in organic solvent. • It is neutral to litmus. Chemical properties • It is a tautomeric mixture of Keto and enol forms. Therefore it gives the reaction of the various functional groups present in the two forms. Acidity of methylene hydrogen (Formation of salt) • In ethyl acetoacetate methylene group (–CH2–) flank by two carbonyl group.
    [Show full text]
  • Ethyl Acetoacetate
    21.6 The Acetoacetic Ester Synthesis Acetoacetic Ester O O C C H3C C OCH2CH3 H H Acetoacetic ester is another name for ethyl acetoacetate. The "acetoacetic ester synthesis" uses acetoacetic ester as a reactant for the preparation of ketones. Deprotonation of Ethyl Acetoacetate O O – C C + CH3CH2O H3C C OCH2CH3 H H Ethyl acetoacetate pKa ~ 11 can be converted readily to its anion with bases such as sodium ethoxide. Deprotonation of Ethyl Acetoacetate O O – C C + CH3CH2O H3C C OCH2CH3 H H Ethyl acetoacetate pKa ~ 11 can be converted readily to its anion K ~ 105 K ~ 10 with bases such as O O sodium ethoxide. C •• C + CH3CH2OH H3C –C OCH2CH3 3 2 H pKa ~ 16 Alkylation of Ethyl Acetoacetate O O The anion of ethyl C •• C acetoacetate can be H C C OCH CH 3 – C OCH2CH3 alkylated using an H alkyl halide (SN2: primary and R X secondary alkyl halides work best; tertiary alkyl halides undergo elimination). Alkylation of Ethyl Acetoacetate O O The anion of ethyl C •• C acetoacetate can be H C C OCH CH 3 – C OCH2CH3 alkylated using an H alkyl halide (SN2: primary and R X secondary alkyl O O halides work best; tertiary alkyl halides C C undergo elimination). H3C C OCH2CH3 H R Conversion to Ketone O O Saponification and C C acidification convert H3C C OH the alkylated H R derivative to the – 1. HO , H2O corresponding b-keto 2. H+ acid. O O The b-keto acid then undergoes C C decarboxylation to H C 3 C OCH2CH3 form a ketone.
    [Show full text]
  • Determination of Solvent Effects on Ketoðenol Equilibria of 1,3-Dicarbonyl Compounds Using NMR: Revisiting a Classic Physical C
    In the Laboratory Determination of Solvent Effects on Keto–Enol Equilibria W of 1,3-Dicarbonyl Compounds Using NMR Revisiting a Classic Physical Chemistry Experiment Gilbert Cook* and Paul M. Feltman Department of Chemistry, Valparaiso University, Valparaiso, IN 46383; *[email protected] “The influence of solvents on chemical equilibria was discovered in 1896, simultaneously with the discovery of keto–enol tautomerism in 1,3-dicarbonyl compounds” (1). The solvents were divided into two groups according to their ability to isomerize compounds. The study of the keto–enol tautomerism of β-diketones and β-ketoesters in a variety of solvents using proton NMR has been utilized as a physical Figure 1. The β-dicarbonyl compounds studied in the experiment. chemistry experiment for many years (2, 3). The first reported use of NMR keto–enol equilibria determination was by Reeves (4). This technique has been described in detail in an experiment by Garland, Nibler, and Shoemaker (2). panded (i) to give an in-depth analysis of factors influencing The most commonly used β-diketone for these experi- solvent effects in tautomeric equilibria and (ii) to illustrate ments is acetylacetone (Scheme I). Use of proton NMR is a the use of molecular modeling in determining the origin of viable method for measuring this equilibrium because the a molecule’s polarity. The experiment’s original benefits of tautomeric keto–enol equilibrium is slow on the NMR time using proton NMR as a noninvasive method of evaluating scale, but enol (2a)–enol (2b) tautomerism is fast on this scale equilibrium are maintained. (5). It has been observed that acyclic β-diketones and β- Experimental Procedure ketoesters follow Meyer’s rule of a shift in the tautomeric equi- librium toward the keto tautomer with increasing solvent Observations of the solvent effects for three other 1,3- polarity (6).
    [Show full text]
  • Atoa Wa Ni Mha La Maison
    ATOAUS009975847B2 WA NI MHA LA MAISON (12 ) United States Patent ( 10 ) Patent No. : US 9 ,975 , 847 B2 Gambogi et al. (45 ) Date of Patent: May 22 , 2018 ( 54 ) AMINO ACID DERIVATIVES AND THEIR 2006 /0013778 A1 1 / 2006 Hodosh 2008/ 0317839 Al * 12/ 2008 Quay .. .. .. .. .. A61K 9 / 1272 USES 424 / 450 ( 71) Applicant: Johnson & Johnson Consumer Inc ., 2010 /0330136 Al 12 /2010 Rocabayera Bonvila Skillman , NJ (US ) FOREIGN PATENT DOCUMENTS (72 ) Inventors : Robert J . Gambogi, Hillsborough , NJ JP 5982310 5 / 1984 (US ) ; Anthony R . Geonnotti, III , WO WO2000 /011022 2 / 2000 Princeton , NJ (US ) ; Michael C . Giano , WO WO2003 /013454 2 / 2003 Southampton , NJ ( US ) ; Latrisha WO WO 2005 /000261 AL 1 /2005 Petersen , Highland Park , NJ (US ) WO WO2008 / 137758 A2 11/ 2008 (73 ) Assignee : Johnson & Johnson Consumer Inc . , OTHER PUBLICATIONS Skillman , NJ (US ) Kazuhiko et al . JPS 5982310 ( A ) ( 1984 ) English Abstracts . * Pinazo , A . ; New cationic vesicles prepared with double chain ( * ) Notice : Subject to any disclaimer , the term of this surfactants fromarginine: Role of the hydrophobic group on the patent is extended or adjusted under 35 antimicrobial activityand cytotoxicity ; Colloids and Surfaces B : U . S . C . 154 (b ) by 15 days. Biointerfaces 141 ( 2016 ) 19 - 27 . International Search Report dated Jan . 21, 2016 ; — Int' l Appln . No. ( 21) Appl . No. : 14 /938 , 334 PCT/ US2015 / 060166 filed Nov . 11, 2015 . Morrison and Boyd , Organic Chemistry Fourth Edition , section ( 22 ) Filed : Nov . 11 , 2015 20 . 3 , p . 814 . Yang Xu and R . F . Pratt , “ -Lactam -Recognizing Enzymes Exhibit (65 ) Prior Publication Data Different Structural Specificity in Acyclic Amide and Ester Sub strates : A Starting point in B -Lactamase Evolution ? ” Bioorganic & US 2016 /0145203 A1 May 26 , 2016 Medicinal Chemistry Letters, vol .
    [Show full text]
  • Ethyl Acetoacetate
    EUROPEAN COMMISSION JOINT RESEARCH CENTRE Institute for Health and Consumer Protection European Chemicals Bureau I-21020 Ispra (VA) Italy ETHYL ACETOACETATE CAS No: 141-97-9 EINECS No: 205-516-1 Summary Risk Assessment Report 2002 Special Publication I.02.75 ETHYL ACETOACETATE CAS No: 141-97-9 EINECS No: 205-516-1 SUMMARY RISK ASSESSMENT REPORT 2002 Germany The Rapporteur for Ethyl acetoacetate is the Federal Institute for Occupational Safety and Health. Contact point: Bundesanstalt für Arbeitsschutz und Arbeitsmedizin Anmeldestelle Chemikaliengesetz (BAuA) (Federal Institute for Occupational Safety and Health Notification Unit) Friedrich-Henkel-Weg 1-25 44149 Dortmund (Germany) fax: +49 (231) 9071-679 e-mail: [email protected] Date of Last Literature Search : 1996 Review of report by MS Technical Experts finalised: March 2001 Final report: 2002 © European Communities, 2002 PREFACE This report provides a summary, with conclusions, of the risk assessment report of the substance ethyl acetoacetate that has been prepared by Germany in the context of Council Regulation (EEC) No. 793/93 on the evaluation and control of existing substances. For detailed information on the risk assessment principles and procedures followed, the underlying data and the literature references the reader is referred to the original risk assessment report that can be obtained from the European Chemicals Bureau1. The present summary report should preferably not be used for citation purposes. 1 European Chemicals Bureau – Existing Chemicals – http://ecb.jrc.it III
    [Show full text]