Lonza's Chemical Network Diketene and HCN Derivatives, Heterocycles

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Lonza’s chemical network Diketene and HCN derivatives, heterocycles and basic chemicals catalog

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Content

About Lonza 3 Introduction 4 Diketene / ketene derivatives 6

Esters 6 Arylides 7 Alkylamides 8 Pyrazolones 9 Dehydroacetic acid 9 Lonzamon monomers 10 Other diketene derivatives 10 HCN derivatives 12 Heterocycles 14 Basic chemicals 16 Others 17 Alphabetical index 18 About Lonza

Lonza is the global leader in the production and support of active phar- From 1897 to the present day combining Swiss tradition with global maceutical ingredients both chemically and biotechnologically. Biophar- experience, the company has had an enterprising character, adapting maceuticals are one of the key growth drivers of the pharmaceutical and its offerings and services to the needs of customers and to changing biotechnology industries. technologies. Throughout our history, we have maintained a strong culture of performance, results and dependability that is valued by all Lonza has strong capabilities in large and small molecules, peptides, of our customers. amino acids and niche bioproducts which play an important role in the development of novel medicines and healthcare products. In addition, Lonza’s cracker in Visp is the back bone of a comprehensive fully back- Lonza is a leader in cell-based research, endotoxin detection and cell ward integrated chemical network. Our product portfolio consists of therapy manufacturing. Furthermore, the company is a leading provider HCN- and diketene derivatives as well as basic chemicals which are key of chemical and biotech ingredients to the nutrition, hygiene, preserva- raw materials and intermediates for many sophisticated applications. tion, agro and personal care markets.

3 Diketene and HCN derivatives, heterocycles and basic chemicals catalog

Diketenes / ketenes

Diketene is a colorless liquid produced by dimerization of ketene. It is Alkylamides: Aliphatic amines react with diketene to result in alkyl- a highly reactive building block which can be combined with numerous amides. Major products such as monomethyl- or dimethylacetoacet- other chemical compounds to make a wide range of products. Because amides are manufactured as aqueous solutions with continuous pro- of its high energy content, transport of diketene is forbidden. It is processes; other derivatives and water-free compounds are produced with cessed further at the site of manufacture. Lonza is one of the world’s batch processes. The (alkyl-) acetoacetamides are used principally in leading suppliers of diketene derivatives manufactured in its production the manufacture of insecticides. The derivatives are also deployed in facility in Visp, Switzerland. Our diketene derivatives are used in the the pigment, pharmaceutical and polymer industries. pharmaceutical, vitamin, agrochemical and pigment industries. The niche markets are in cosmetics, plasticizers, paints. The acetoacyl group DHS / NaDHS: The catalytic dimerization of diketene yields dehydroacetic in diketene derivatives has a broad functionality which can be used acid (DHS), which is a solid material. The free acid can be neutralized for the production of further products. Lonza’s most comprehensive with sodium hydroxide and is available as the salt NaDHS or its monohy- diketene product lines are those made with alcohols (aceto-acetic acid drate NaDHS-H2O. These products are used above all in the manufacture and acrylate derivatives), aliphatic amines (alkylamides) and aromatic of PVC stabilizers and as preservatives in the cosmetic industries. amines (arylamides). Lonza uses some of these to produce further components (pyrazolones, aminocrotonates, side chains). Acrylic acid esters (acetoacetoxy monomers): Acetoacetoxyethyl methacrylate (AAEMA), the most important product of this group, is made The following summary provides an overview of the diketene derivative in a multipurpose batch production plant. It is used as a copolymer for product groups: coatings and adhesives in emulsion polymerization (waterborne disper- sions) or solvent polymerization (high solids), and provides improved Diketene esters (acetoacetates): “Major” products such as methyl, mechanical and solvent resistance to water or organic solvents. It also ethyl, isopropylester of acetoacetic acid are produced in a continuous promotes adhesion to metallic, mineral and wood surfaces. process and purified by distillation. “Minor” derivatives are produced batchwise in stirred vessel reactors. The products are used mostly in Other diketene derivatives: 4-Chloroacetoacetic acid ester is a highly the dye, agrochemical, pharmaceutical and vitamin industries. versatile diketene derivative. It can be used in syntheses of various pharmaceutical intermediates. Arylamides: A large variety of arylamides are obtained by the reaction of aromatic amines with diketene. Our most important products are AAA, Ketene: Lonza has the specific capability to perform a variety of reac- AAOT, AAMX, AAOA, and AAOC; others are made regularly or on special tions with ketene. The production of ethyl 4, 4, 4-trifluoroacetoacetate request. These derivatives are used mainly in the production of azo is one example for such a ketene reaction. pigments; but also in the dye and agrochemical industries. For more information about ketene / diketene chemistry and its various derivatives, please ask for specific brochures and related literature or send mail to [email protected].

4 Hydrocyanic acid (HCN)

Hydrogen cyanide is a extremely poisonous colorless or pale-blue liquid that undergoes a wide variety of reactions. Lonza has manufacturing capabilities to offer a solution of hydrogen cyanide in water (hydrocyanic acid) and producing its derivatives. HCN is used in metallurgical and photographic processes. Furthermore, HCN is a starting material for cyanogen chloride, cyanoacetates, cyanohydrins, sodium cyanide, chelating agents and many more. Cyanogen chloride is a functional building block for other Lonza products like cyanuric chloride and malononitrile. The cyanohydrins, give access to a variety of useful organic compounds including the monomer methyl methacrylate, amino acids via the Strecker synthesis, and the chelating agents EDTA and NTA.

Basic chemicals

Beside ketene and HCN chemicals Lonza’s cracker related product portfolio also offers a selective number of basic chemicals. The chemicals can be used as starting materials and processed further to yield coatings, colorants, adhesives, medicines, agrochemicals and more.

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Various

5 Diketene and HCN derivatives, heterocycles and basic chemicals catalog

Methyl acetoacetate (MAA) Ethyl acetoacetate (EAA) Diketene / Esters C H O C H O ketene 5 8 3 5 10 3 derivatives

Molecular weight 116.12 130.14 CAS RN 105-45-3 141-97-9 Minimum assay 99.0 % 99.0 % Minimum stability 2 years 2 years Melting point ca. –28°C –43°C Boiling point ca. 170°C 180°C Density g/cm3 (20°C) 1.077 1.03 EU labeling Xi irritant – Packaging drums, bulk drums, bulk Transport information not restricted not restricted

Isopropyl acetoacetate (IPAA) Isobutyl acetoacetate (AAisobutyl) t-Butyl acetoacetate (AA-t-butyl)

C7H12O3 C8H14O3 C8H14O3

Molecular weight 144.17 158.20 158.20 CAS RN 542-08-5 7779-75-1 1694-31-1 Minimum assay 98.5 % 98.0 % 98.0 % Minimum stability 2 years 2 years 2 years Melting point ca. –27°C –20.5°C –38°C Boiling point ca. 185°C 205°C 71°C / 15hPa Density g/cm3 (20°C) 0.998 0.974 0.970 EU labeling Xi irritant – – Packaging drums, bulk drums drums Transport information not restricted not restricted not restricted

N-Benzyl-N-methyl-2-aminoethyl- Benzyl acetoacetate (BAA) acetoacetate (AABME) Dodecyl acetoacetate (AAdodecyl)

C11H12O3 C14H19NO3 C16H30O3

Molecular weight 192.22 249.31 270.42 CAS RN 5396-89-4 54527-65-0 52406-22-1 Minimum assay – 95.0 % 96.0 % Minimum stability 2 years 8 months 2–3 years Melting point ca. 12°C – – Boiling point ca. 275°C dec. 175°C dec. 190°C /20 hPa Density g/cm3 (20°C) 1.114 1.067 0.914 EU labeling Xi irritant – Xi irritant Packaging drums drums drums Transport information not restricted not restricted not restricted

6 2-Methoxyethyl acetoacetate 4-Nitrobenzyl acetoacetate Ethyl benzoylacetate-91 (BESethyl-91) (AAmethoxyethyl) (30 % in toluene) (PNBAA 30T)

C11H12O3 C7H12O4 C11H11NO5

Molecular weight 192.22 160.16 237.21 CAS RN 94-02-0 22502-03-0 61312-84-3 Minimum assay 91.0 % 97.5 % 270-330 g/l Minimum stability 2 years 2 years 9 months Melting point ca. – – – Boiling point ca. 93°C / 10 Pa 118°C / 26hPa – Density g/cm3 (20°C) – 1.091 – EU labeling – T toxic F, Xn; R11-38-48/20-63-65-67 Packaging drums drums iron drums 56.25 kg, 187.5 kg Transport information not restricted not restricted UN 1993, 3, PG II

Acetoacetanilide (AAA) Acetoacetanilide, flakes( AAA,flakes)

Arylides C10H11NO2 C10H11NO2

Molecular weight 177.20 177.20 CAS RN 102-01-2 102-01-2 Minimum assay 99.5 % 95.0 % Minimum stability 2 years 9 months Melting point ca. 83.0°C 62.0°C Boiling point ca. – – Density g/cm3 (20°C) – – EU labeling Xn harmful Xn harmful Packaging paper bags, big bags big bags Transport information not restricted not restricted

Acetoacet-o-toluidide (AAOT) Acetoacet-m-xylidide (AAMX)

C H NO C H NO 11 13 2 12 15 2 Pharma

Colorants

Agriculture Molecular weight 191.23 205.26 CAS RN 93-68-5 97-36-9 Minimum assay 99.5 % 99.5 % Polymers Minimum stability 2 years 2 years Melting point ca. 103.5°C 89°C Boiling point ca. – – Nutrition Density g/cm3 (20°C) – – EU labeling Xn harmful Xn harmful Various Packaging paper bags, big bags paper bags, big bags Transport information not restricted not restricted

7 Diketene and HCN derivatives, heterocycles and basic chemicals catalog

Acetoacet-4-chloro-2,5-dimethoxy- Acetoacet-o-chloroanilide (AAOC) Acetoacet-o-anisidide (AAOA) anilide (ASIRG) Diketene / C H ClNO C H NO C H ClNO ketene 10 10 2 11 13 3 12 14 4 derivatives

Molecular weight 211.65 207.23 271.70 CAS RN 93-70-9 92-15-9 4433-79-8 Minimum assay 99.5 % 99.5 % 98.0 % Minimum stability 2 years 2 years 2 years Melting point ca. 103.5°C 83.5°C 104°C Boiling point ca. – – – Density g/cm3 (20°C) – – – EU labeling Xn harmful Xn harmful Xn harmful Packaging paper bags paper bags, big bags paper bags Transport information not restricted not restricted not restricted

Acetoacet-5-chloro-2-methoxy- Potassium N-(acetoacetyl) anilide (AAMOC) sulfanilate (AAsulfanil-K)

C11H12ClNO3 C10H10KNO5S Alkylamides

Molecular weight 241.68 295.36 CAS RN 52793-11-0 70321-85-6 Minimum assay 99.0 % 96.0 % Minimum stability 2 years 2 years Melting point ca. 92°C >300°C Boiling point ca. – – Density g/cm3 (20°C) – – EU labeling – – Packaging paper bags paper bags, big bags Transport information not restricted not restricted

N,N-Dimethylacetoacetamide N-Methylacetoacetamide (MMAA) (DMAA-80) N,N-Diethylacetoacetamide (DEAA)

C5H9NO2 C6H11NO2 C8H15NO2

Molecular weight 115.13 129.16 157.21 CAS RN 20306-75-6 2044-64-6 2235-46-3 Minimum assay 70.0 % 80.0 % 98.0 % Minimum stability 2 months 6 months 3 months Melting point ca. – – – Boiling point ca. 110°C 106°C 213°C Density g/cm3 (20°C) 1.078 1.060 0.995 EU labeling – – – Packaging drums, bulk drums, bulk drums, bulk Transport information not restricted not restricted not restricted

8 Acetoacetamide (AAmid) 3-Methyl-5-pyrazolone (MP)

C4H7NO2 Pyrazolones C4H6N2O

Molecular weight 101.11 98.11 CAS RN 5977-14-0 108-26-9 Minimum assay 98.5 % 99.0 % Minimum stability 18 months 2 years Melting point ca. 52°C 217°C Boiling point ca. – – Density g/cm3 (20°C) – – EU labeling – – Packaging paper bags drums Transport information not restricted not restricted

3,5-Dimethylpyrazole (DMP) Dehydroacetic acid (DHS)

C5H8N2 Dehydroacetic acid C8H8O4

Molecular weight 96.13 168.15 CAS RN 67-51-6 520-45-6 Minimum assay 99.0 % 99.0 % Minimum stability 3 years 2 years Melting point ca. 107°C 109°C Boiling point ca. 218°C – Density g/cm3 (20°C) – – EU labeling – Xn harmful Packaging drums paper bags Transport information not restricted not restricted

Dehydroacetic acid, sodium salt Dehydroacetic acid, sodium salt (NaDHS) monohydrate (NaDHS-H2O)

C H O Na C H O Na 8 7 4 8 9 5 Pharma

Colorants

Agriculture Molecular weight 190.13 208.15 CAS RN 4418-26-2 64039-28-7 Minimum assay 99.0 % 98.0 % Polymers Minimum stability 2 years 2 years Melting point ca. – 109°C Boiling point ca. – – Nutrition Density g/cm3 (20°C) – – EU labeling Xn harmful Xn harmful Various Packaging drums drums Transport information not restricted not restricted

9 Diketene and HCN derivatives, heterocycles and basic chemicals catalog

2-(Acetoacetoxy) ethylmethacrylate Propane-1.1.1-triyltrimethyl tris (AAEMA) (acetoacetate) (AATMP) Diketene / Lonzamon monomers C H O C H O ketene 10 14 5 18 26 9 derivatives

Molecular weight 214.21 386.4 CAS RN 21282-97-3 22208-25-9 Minimum assay 95.0 % 92.0 % Minimum stability 1 year 2 years Melting point ca. –60°C –30°C Boiling point ca. 100°C / 1hPa 300°C Density g/cm3 (20°C) 1.122 – EU labeling Xi irritant – Packaging drums drums Transport information not restricted not restricted

Squaric acid (QS) Diethyl squarate (QS, diethyl)

Other diketene / ketene C4H2O4 C8H10O4 derivatives

Molecular weight 114.06 170.17 CAS RN 2892-51-5 5231-87-8 Minimum assay 98.5 % 98.0 % Minimum stability 2 years 12 months Melting point ca. 293°C 4–8°C (solidification) Boiling point ca. – 95°C / 0.1 hPa Density g/cm3 (20°C) 1.82 1.15 EU labeling – T toxic; R21-25-36/37/38-42-43 Packaging drums iron drums Transport information not restricted UN 2810, 6.1, PG III

Diacetoacet-1,4-phenylenediamide Diacetoacet-2,5-dimethyl-1,4- Diacetoacet-o-tolidide (DiAA-o-tolidid) (DiAAphen) phenylenediamide (DiAA DM)

C22H24N2O4 C14H16N2O4 C16H20N2O4

Molecular weight 380.45 276.29 304.38 CAS RN 91-96-3 24731-73-5 24304-50-5 Minimum assay 98.0 % 98.5 % 98.0 % Minimum stability 2 years 2 years 2 years Melting point ca. 206°C 171°C 232°C Boiling point ca. – – – Density g/cm3 (20°C) – – – EU labeling – – – Packaging bag-in-box, drums paper bags paper bags Transport information not restricted not restricted not restricted

10 Diacetoacet-2-chloro-5-methyl-1,4- Diacetoacet-2,5-dichloro-1,4- phenylenediamide (DiAA MC) phenylenediamide (DiAA DC) Methyl 3-aminocrotonate (ACMe)

C15H17ClN2O4 C14H14Cl2N2O4 C5H9NO2

Molecular weight 324.77 345.18 115.13 CAS RN 41131-65-1 42487-09-2 14205-39-1 Minimum assay 97.0 % 97.0 % 98.0 % Minimum stability 5 years 5 years – Melting point ca. 192°C 197°C 81°C Boiling point ca. – – 112°C / 55hPa Density g/cm3 (20°C) – – – EU labeling – – Xi irritant Packaging paper bags paper bags drums Transport information not restricted not restricted not restricted

1,4-Butyleneglycolbis Thiodiglycolbis (3-aminocrotonate) (BGAC) Diketene-acetone adduct (DAA) (3-aminocrotonate) (TGAC)

C12H20N2O4 C7H10O3 C12H20N2O4S

Molecular weight 256.30 142.16 288.37 CAS RN 14205-47-1 5394-63-8 13560-49-1 Minimum assay 96.0 % 93.0 % 96.0 % Minimum stability 2 years 3 months 2 years Melting point ca. 146°C 12°C 88°C Boiling point ca. – 66°C / 3mbar – Density g/cm3 (20°C) – 1.094 – EU labeling – F flammable N environment Packaging bag-in-box drums fibre container Transport information not restricted UN-No.: 1993, 3, PG II UN-No.: 3077, 9, PG III

2,5-Dimethyl-2,4-dihydro- pyrazol-3-on (DMPO) Ethyl 4-chloroacetoacetate (CAAEt)

C H N O C H ClO 5 8 2 6 9 3 Pharma

Colorants

Agriculture Molecular weight 112.13 164.59 CAS RN 2749-59-9 638-07-3 Minimum assay >98.0 % 97.0 % Polymers Minimum stability – 1 year Melting point ca. 117–118°C –8.5°C Boiling point ca. 105–115°C / 8 hPa 220°C Nutrition Density g/cm3 (20°C) 1.14 1.212 EU labeling Xi irritant T toxic, N environment Various Packaging – drums Transport information not restricted UN-No.: 2922, 8, PG II

11 Diketene and HCN derivatives, heterocycles and basic chemicals catalog

Ethyl 4,4,4-trifluoroacetoacetate Methyl 3,3-dimethoxypropanoate (E)-Methyl 3-methoxyacrylate (ETFAA) (PRSMe,DM) (E-MMA) Diketene / C H F O C H O C H O ketene 6 7 3 3 6 12 4 5 8 3 derivatives

Molecular weight 184.12 148.16 116.12 CAS RN 372-31-6 7424-91-1 34846-90-7, 5788-17-0 (linear structure) Minimum assay 98.0 % 98.0 % ≥98.0 % Minimum stability 6 months 12 months 2 years Melting point ca. –39°C <–65°C 2–3°C Boiling point ca. 131°C 77°C / 26 mbar 95°C / 100 hPa Density g/cm3 (20°C) 1.2586 1.06 1.07 EU labeling Xn harmful – – Packaging drums – – Transport information not restricted not restricted not restricted

Methyl 4-methyl-3-oxopentanoate (OPMe, 4-methyl)

C H O 7 12 3 Pharma

Colorants

Agriculture Molecular weight 144.17 CAS RN 42558-54-3 Minimum assay 98.0 % Polymers Minimum stability 12 months Melting point ca. –75°C Boiling point ca. 192°C Nutrition Density g/cm3 (20°C) 1.01 EU labeling – Various Packaging drum or iso-container Transport information not restricted

Adenine Cyanuric chloride A (CC A) Cyanuric chloride AS (CC AS) HCN C H N C Cl N C Cl N derivatives 5 5 5 3 3 3 3 3 3

Molecular weight 135.13 184.41 184.41 CAS RN 73-24-5 108-77-0 108-77-0 Minimum assay 98.0–102.0 % 99.5 % 99.5 % Minimum stability 2 years 6 months 6 months Melting point ca. 360°C 145.0–147.0°C 145.0–147.0°C Boiling point ca. – 193°C / 1013 hPa 193°C / 1013 hPa Density g/cm3 (20°C) – – – EU labeling – – – Packaging drums bags in box big bags Transport information not restricted not restricted not restricted

12 2-Methoxyethyl cyanoacetate Allyl cyanoacetate (CNESallyl) Butyl cyanoacetate (CNESbutyl) (CNES methoxyet)

C6H7NO2 C7H11NO2 C6H9NO3

Molecular weight 125.13 141.17 143.14 CAS RN 13361-32-5 5459-58-5 10258-54-5 Minimum assay 99.0 % 99.0 % ≥99.0 % Minimum stability 2 years 2 years 2 years Melting point ca. –40°C – – Boiling point ca. 89–90°C / 5 hPa 109.0°C / 13.0 hPa 257°C / 1000 hPa Density g/cm3 (20°C) – 0.998–1.002 – EU labeling T toxic; R25 – – Packaging drums 200 kg drums 200 kg iron drums 200 kg, container Transport information UN 3276, 6.1, PG III not restricted not restricted

Malononitrile (85 % in methanol) Chlorosulfonyl isocyanate (CSI) Malononitrile (MDN) (MDN)

CClNO3S C3H2N2 C3H2N2 ; CH4O

Molecular weight 141.53 66.06 98.11 CAS RN 1189-71-5 109-77-3 109-77-3 Minimum assay 99.0–100.3 % 99.0 % 83.5–86.5 % Minimum stability 12 months 18 months 2.5 months Melting point ca. – – 19.5°C Boiling point ca. 1060°C 218–219°C – Density g/cm3 (20°C) 1.626 1.0494 (35°C) 1.011 (35°C) EU labeling C corrosive; R14-20/21/22-34 T toxic, N environment; R23/24/25-50/53 T,N; R10-23/24/25-39/23/24/25-50/53 Packaging drums drums drums, rail tank wagon Transport information UN 3264, 8, PG I UN 2647, 6.1, PG ll UN 2929, 6.1 (3), PG ll

3-Aminocrotononitrile (Diacetonitril) Sodium dicyanamide (Na-dicyanamide) 1,1,3,3-Tetramethylguanidine (TMG)

C4H6N2 C2N3Na C5H13N3

Molecular weight 82.11 89.03 115.18 CAS RN 1118-61-2 1934-75-4 80-70-6 Minimum assay 96.0 % ≥97.0 % 99.0 % Minimum stability 8 months 2 years 1 year Melting point ca. 40–67°C >260°C – Boiling point ca. – – 162°C / 1013 hPa Density g/cm3 (20°C) 0.9520 (77°C) – 0.92 EU labeling – – – Packaging drums drums, BB packaging on request drums, bulk Transport information not restricted not restricted not restricted

13 Diketene and HCN derivatives, heterocycles and basic chemicals catalog

Akolidine 10 Akolidine 11 Akolidine 12 (Pyridine, alkyl derivatives) (Pyridine, alkyl derivatives) (Pyridine, alkyl derivatives) Heterocycles All akolidines contain the following components:

Molecular weight – – – CAS RN 68391-11-7 68391-11-7 68391-11-7 Minimum assay – – – Minimum stability – – – Melting point ca. – – – Boiling point ca. – – – Density g/cm3 (20°C) 0.978–0.990 1.018–1.034 1.024–1.038 EU labeling – – – Packaging iron drum, bulk iron drum, bulk iron drum, bulk Transport information not restricted not restricted not restricted

2-Amino-4,6-dimethoxypyrimidine 2-Chloro-4,6-dimethoxypyrimidine 2-(5-Ethyl-2-pyridyl)ethanol (ADMP) (DMP, 2-Chlor) (PRD-2-etol, 5-Et)

C6H9N3O2 C6H7ClN2O2 C9H13NO

Molecular weight 155.16 174.59 151.21 CAS RN 36315-01-2 13223-25-1 5223-06-3 Minimum assay 98.0–101.0 % 98.0–100.3 % 95.0 % Minimum stability 2 years 2 years 2 years Melting point ca. 96–98°C 102–104°C 45°C Boiling point ca. – – 147–149°C Density g/cm3 (20°C) – – 1.042 EU labeling – – – Packaging drums drums iron drum 200 kg Transport information not restricted not restricted not restricted

5-Ethyl-2-methylpyridine (MEP) 6-Hydroxynicotinic acid (NS,6-Hydroxy) Sodium nicotinate (NS-Na)

C8H11N C6H5NO3 C6H4NNaO2

Molecular weight 121.18 139.11 145.09 CAS RN 104-90-5 5006-66-6 54-86-4 Minimum assay – 97.5–100.3 % 99.0–100.3 % Minimum stability 1 year 2–3 years 3 years Melting point ca. –70.9°C 314–316°C 410°C Boiling point ca. 178.3°C – – Density g/cm3 (20°C) 0.918–0.921 – – EU labeling – – – Packaging iron drum 180 kg drums drums Transport information not restricted not restricted not restricted

14 Niacin min. 99.5 % (NS fg) Niacinamide USP (NSA USP) Meta™ metaldehyde (META tc)

C6H5NO2 C6H6N2O C8H16O4

Molecular weight 123.11 122.13 176.21 CAS RN 59-67-6 98-92-0 108-62-3 Minimum assay 99.5–100.3 % 99.0–101.0 % 98.0–99.8 % Minimum stability 3 years 3 years 3 years (10°C) Melting point ca. 234.0–237.0°C 128.0–131.0°C 246°C Boiling point ca. – – – Density g/cm3 (20°C) – – – EU labeling – – – Packaging paper bags, big bags bag-in-box 20 kg bag-in-box 25 kg Transport information not restricted not restricted not restricted

Paraldehyde (PARA) 2-Picoline (Picoline,2) 4-Picoline (Picoline,4)

C6H12O3 C6H7N C5H7N

Molecular weight 132.16 93.13 93.13 CAS RN 123-63-7 109-06-8 108-89-4 Minimum assay 99.5 % 99.0 % >98.0 % Minimum stability 60 days 2 years – Melting point ca. – –66.8°C 3.6°C Boiling point ca. – 125–130°C 145.4°C Density g/cm3 (20°C) 0.993–0.997 kg/l (20°C) – 0.954 EU labeling – – T toxic; R10, R20/22, R24, R36/37/38 Packaging iron drum 200 kg, bulk iron drum 180 kg, bulk – Transport information not restricted not restricted not restricted

4,6-Dimethoxy-2-[(phenoxy- Pyrimidine (<0.5 % water) carbonyl)amino]pyrimidine (Pyrimidine W<0.5) (ADMP-carbamat)

C H N C H N O 4 4 2 13 13 3 4 Pharma

Colorants

Agriculture Molecular weight 80.09 275.26 CAS RN 289-95-2 89392-03-0 Minimum assay 98.5–100.0 % 97.0–101.0 % Polymers Minimum stability 2 years 2 years Melting point ca. 20–22°C 120–122°C Boiling point ca. 122–24°C > 250°C Nutrition Density g/cm3 (20°C) 1.016 – EU labeling – – Various Packaging drums drums Transport information not restricted not restricted

15 Diketene and HCN derivatives, heterocycles and basic chemicals catalog

Acetaldehyde (AcAl) Acetic acid (glacial) (ES 99) Acetic anhydride (ESanhydrid) Basic C H O C H O C H O chemicals 2 4 2 4 2 4 6 3

Molecular weight 44.05 60.05 102.09 CAS RN 75-07-0 64-19-7 108-24-7 Minimum assay 99.5 % 99.5–100.0 % 99.5 % Minimum stability 1 year 2 years 2 years Melting point ca. –123.5°C 15.8–16.3°C –73°C Boiling point ca. 21°C 113–115°C / 933 hPa – Density g/cm3 (20°C) 0.784–0.786 kg/l (15°C) 1.050 g/ml (20°C) 1.0820 EU labeling – – – Packaging drums, bulk drum 200 kg, bulk drums 200 kg, rail tanker Transport information not restricted not restricted not restricted

Ammonia aqueous (Ammonia 24) Ammonia techn. (Ammonia tc) approx. 24.5–24.9 % chemically pure Nitric acid 65 %

NH3 NH3 HNO3

Molecular weight 17.03 17.03 63.01 CAS RN 7664-41-7 1336-21-6 7697-37-2 Minimum assay 99.8 % 24.5–24.9 % 65.0–65.5 % Minimum stability 2 years 2 years – Melting point ca. – – –33°C Boiling point ca. 33.4°C / 1013 hPa – 121°C / 1013 hPa Density g/cm3 (20°C) 0.609 0.9150–0.9110 g/ml (15°C) – EU labeling – – – Packaging rail tanker drums, road and rail tanker rail tanker Transport information not restricted not restricted not restricted

Nitrosylsulfuric acid 40 % (SS,Nitrosyl 40) Malonic acid (MA)

HNO5S C3H4O4

Molecular weight 127.08 104.06 CAS RN 7782-78-7 141-82-2 Minimum assay 39.5–40.5 % 99 % Minimum stability 2 years 1 year Melting point ca. –12 – –3°C 134°C (Mettler) Boiling point ca. 333°C – Density g/cm3 (20°C) 1.893 – EU labeling – Xi irritant; R36 Packaging rail tanker bags Transport information not restricted not restricted

16 2,6-Diethyl-4-methylaniline (DEMA) 2,6-Diisopropylaniline (DIPA) 4,4-Dimethoxy-butan-2-one (DMB) Others C11H17N C12H19N C6H12O3

Molecular weight 163.26 177.29 132.16 CAS RN 24544-08-9 24544-04-5 5436-21-5 Minimum assay >98.0 % 92.0 % >92.0 % Minimum stability 1 year 1 year 2 years Melting point ca. –12°C – –7°C –45°C –83 – –81°C Boiling point ca. – 257°C / 1013 mbar 169–71°C Density g/cm3 (20°C) 0.945 0.940 0.9977 EU labeling Xn harmful; R21/22 R52/53 – Packaging steel drums, bulk iron drum 180 kg, bulk drums, bulk Transport information not restricted not restricted not restricted

Valeronitrile (VN)

C H N 5 9 Pharma

Colorants

Agriculture Molecular weight 83.13 CAS RN 110-59-8 Minimum assay 99.5 % Polymers Minimum stability 2 years Melting point ca. – Boiling point ca. 139–141°C / 1013 hPa Nutrition Density g/cm3 (20°C) 0.7990 EU labeling – Various Packaging drums, bulk Transport information not restricted

17 Diketene and HCN derivatives, heterocycles and basic chemicals catalog

Alphabetical index

Page Product Abbreviation Page Product Abbreviation

A D 16 Acetaldehyde AcAl 9 Dehydroacetic acid DHS 16 Acetic acid (glacial) ES 99 9 Dehydroacetic acid sodium salt monohydrate NaDHS-H2O 16 Acetic anhydride ESanhydrid 9 Dehydroacetic acid sodium salt NaDHS 9 Acetoacetamide AAamid 11 Diacetoacet-2-chloro-5-methyl-1,4-phenylenediamide DiAA MC 7 Acetoacetanilide AAA 11 Diacetoacet-2,5-dichloro-1,4-phenylenediamide DiAA DC 8 Acetoacet-4-chloro-2,5-dimethoxyanilide ASIRG 10 Diacetoacet-2,5-dimethyl-1,4-phenylenediamide DiAA DM 8 Acetoacet-5-chloro-2-methoxyanilide AAMOC 10 Diacetoacet-1,4-phenylenediamide DiAAphen 7 Acetoacet-m-xylidide AAMX 10 Diacetoacet-o-tolidide DiAA-o-tolidid 8 Acetoacet-o-anisidide AAOA 8 N,N-Diethylacetoacetamide DEAA 8 Acetoacet-o-chloroanilide AAOC 10 Diethyl squarate QS, diethyl 7 Acetoacet-o-toluidide AAOT 16 2,6-Diethyl-4-methylaniline DEMA 10 2-(Acetoacetoxy)ethyl methacrylate AAEMA 11 Diketene-acetone adduct DAA 12 Adenine Adenine 16 2,6-Diisopropylaniline DIPA 14 Akolidine 10 Akolidine 10 16 4,4-Dimethoxy-butan-2-one DMB 14 Akolidine 11 Akolidine 11 15 4,6-Dimethoxy-2-[(phenoxy-carbonyl)amino]pyrimidine (ADMP-carbamat) 14 Akolidine 12 Akolidine 12 8 N,N-Dimethylacetoacetamide DMAA 13 Allyl cyanoacetate CNESallyl 11 2,5-Dimethyl-2,4-dihydro-pyrazol-3-on DMPO 14 2-Amino-4,6-dimethoxypyrimidine ADMP 9 3,5-Dimethylpyrazole DMP 13 3-Aminocrotononitrile Diacetonitril 6 Dodecyl acetoacetate AAdodecyl 16 Ammonia aqueous approx. 24.5–24.9 % chemically pure Ammonia 24 10 Ammonia techn. Ammonia tc E 6 Ethyl acetoacetate EAA B 7 Ethyl benzoylacetate BESethyl 6 Benzyl acetoacetate BAA 11 Ethyl 4-chloroacetoacetate CAAEt 6 N-Benzyl-N-methyl-2-aminoethylacetoacetate AABME 14 5-Ethyl-2-methylpyridine MEP 13 Butyl cyanoacetate CNESbutyl 14 2-(5-Ethyl-2-pyridyl)ethanol PRD-2-etol, 5-Et 6 t-Butyl cyanoacetate AA-t-butyl 12 Ethyl 4,4,4-trifluoroacetoacetate ETFAA 11 1,4-Butyleneglycolbis(3-aminocrotonate) BGAC H C 14 6-Hydroxynicotinic acid NS,6-Hydroxy 14 2-Chloro-4,6-dimethoxypyrimidine DMP, 2-Chlor 13 Chlorosulfonyl isocyanate CSI I 12 Cyanuric chloride A CC A 6 Isobutyl acetoacetate AAisobutyl 12 Cyanuric chloride AS CC AS 6 Isopropyl acetoacetate IPAA

M 16 Malonic acid MA 13 Malononitrile (85 % in methanol) MDN 13 Malononitrile MDN 15 Meta™ metaldehyde META tc 7 2-Methoxyethyl acetoacetate AAmethoxyethyl 13 2-Methoxyethyl cyanoacetate CNES methoxyet 9 3-Methyl-5-pyrazolone MP 12 Methyl 3,3-dimethoxypropanoate PRSMe,DM 11 Methyl 3-aminocrotonate ACMe 12 (E)-Methyl 3-methoxyacrylate E-MMA 12 Methyl 4-methyl-3-oxopentanoate OPMe, 4-methyl 8 N-Methylacetoacetamide MMAA 6 Methyl acetoacetate MAA

18 Page Product Abbreviation

N 15 Niacin min. 99.5 % NS fg 15 Niacinamide USP NSA USP 16 Nitric acid 65 % 7 4-Nitrobenzyl acetoacetate (30 % in toluene) PNBAA 30T 16 Nitrosylsulfuric acid 40 % SS,Nitrosyl 40

P 15 Paraldehyde PARA 15 2-Picoline Picoine,2 15 4-Picoline Picoline,4 8 Potassium N-(acetoacetyl)sulfanilate AAsulfanil-K 10 Propane-1,1,1-triyltrimethyl tris(acetoacetate) AATMP 15 Pyrimidine (<0.5 % water) Pyrimidine W<0.5

S 13 Sodium dicyanamide Na-dicyanamide 14 Sodium nicotinate NS-Na 10 Squaric acid QS

T 13 1,1,3,3-Tetramethylguanidine TMG 11 Thiodiglycolbis(3-aminocrotonate) TGAC

V 16 Valeronitrile VN www.lonza.com

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