Dissociation Constants of Organic Acids and Bases ⇌ + - This Table Lists the Dissociation (Ionization) Constants of Over BH + OH
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A Monitoring of Allantoin, Uric Acid, and Malondialdehyde Levels In
A Monitoring of Allantoin, Uric Acid, and Malondialdehyde Levels in Plasma and Erythrocytes after a 10-Minute Running Activity ROMAN KANĎÁR, XENIE ŠTRAMOVÁ, PETRA DRÁBKOVÁ, JANA KŘENKOVÁ Department of Biological and Biochemical Sciences, Faculty of Chemical Technology, University of Pardubice, Pardubice, Czech Republic A running title: Allantoin and Uric Acid Levels after Running Activity Correspondence to: Roman Kanďár, Ph.D., Department of Biological and Biochemical Sciences, Faculty of Chemical Technology, University of Pardubice, Studentska 573, 532 10 Pardubice, Czech Republic Tel.: +420 466037714 Fax: +420 466037068 E-mail: [email protected] Keywords: allantoin, uric acid, oxidative stress, antioxidants, short-term intense exercise 1 Summary Uric acid is the final product of human purine metabolism. It was pointed out that this compound acts as an antioxidant and is able to react with reactive oxygen species forming allantoin. Therefore, the measurement of allantoin levels may be used for the determination of oxidative stress in humans. The aim of the study was to clarify the antioxidant effect of uric acid during intense exercise. Whole blood samples were obtained from a group of healthy subjects. Allantoin, uric acid, and malondialdehyde levels in plasma and erythrocytes were measured using a HPLC with UV/Vis detection. Statistical significant differences in allantoin and uric acid levels during short-term intense exercise were found. Immediately after intense exercise, the plasma allantoin levels increased on the average of two hundred per cent in comparison to baseline. Plasma uric acid levels increased slowly, at an average of twenty per cent. On the other hand, there were no significant changes in plasma malondialdehyde. -
Report of the Advisory Group to Recommend Priorities for the IARC Monographs During 2020–2024
IARC Monographs on the Identification of Carcinogenic Hazards to Humans Report of the Advisory Group to Recommend Priorities for the IARC Monographs during 2020–2024 Report of the Advisory Group to Recommend Priorities for the IARC Monographs during 2020–2024 CONTENTS Introduction ................................................................................................................................... 1 Acetaldehyde (CAS No. 75-07-0) ................................................................................................. 3 Acrolein (CAS No. 107-02-8) ....................................................................................................... 4 Acrylamide (CAS No. 79-06-1) .................................................................................................... 5 Acrylonitrile (CAS No. 107-13-1) ................................................................................................ 6 Aflatoxins (CAS No. 1402-68-2) .................................................................................................. 8 Air pollutants and underlying mechanisms for breast cancer ....................................................... 9 Airborne gram-negative bacterial endotoxins ............................................................................. 10 Alachlor (chloroacetanilide herbicide) (CAS No. 15972-60-8) .................................................. 10 Aluminium (CAS No. 7429-90-5) .............................................................................................. 11 -
Allantoin-Hydrolyzed Animal Protein Product
Patentamt JEuropaischesEuropean Patent Office ® Publication number: 0 087 374 Office européen des brevets B1 (Î2) EUROPEAN PATENT SPECIFICATION (45) Dateof publication of patent spécification: 27.05.87 ® Int. Cl.4: A 23 J 3/00, A 61 K 7/48 (§) Application number: 83400376.6 (22) Date of filing: 23.02.83 (54) Allantoin-hydrolyzed animal protein product. (30) Priority: 24.02.82 US 351722 (73) Proprietor: CHARLES OF THE RITZ GROUP LTD. 01.06.82 US 383404 40 West 57th Street 13.12.82 US 449117 New York, NY 10019 (US) (§) Dateof publication of application: (72) Inventor: Puchalski, Eugène 31.08.83 Bulletin 83/35 129 McAdoo Avenue Jersey City New Jersey (US) Inventor: Deckner, George E. (§) Publication of the grant of the patent: 645 Horst Street 27.05.87 Bulletin 87/22 Westfield New Jersey (US) Inventor: Dixon, Richard P. 23 Avondale Lane (§) Designated Contracting States: Aberdeen New Jersey (US) AT BE CH DE FR GB IT Ll LU NL SE Inventor: Donahue, Frances A. 2 Kimberley Court Apt. 16 Middletown New Jersey (US) (58) Références cited: FR-A-2510 563 Y- US-A-3 941722 (74) Représentative: Maiffret, Bernard et al Cû Law Offices of William J. Rezac 49, avenue SOAP, PERFUMERY AND COSMETICS, vol. 49, Franklin D. Roosevelt no. 11, November 1976, pages 481-485. S. B. F-75008 Paris (FR) ^ MECCA: "Uric acid, allantoin and allantoin ^ derivatives" SE1FEN- OLE - FETTE - WACHSE, vol. 97, no. 15, N 1971, pages 533-534. S. B. MECCA: "Neue 00 Allantoin-Derivate fur die kosmetische und O dermatologische Anwendung" C9 Note: Within nine months from the publication of t\the mention of the grant of the European patent, any person may give notice to the European Patent Office of opposopposition to the European patent granted. -
Inventory Size (Ml Or G) 103220 Dimethyl Sulfate 77-78-1 500 Ml
Inventory Bottle Size Number Name CAS# (mL or g) Room # Location 103220 Dimethyl sulfate 77-78-1 500 ml 3222 A-1 Benzonitrile 100-47-0 100ml 3222 A-1 Tin(IV)chloride 1.0 M in DCM 7676-78-8 100ml 3222 A-1 103713 Acetic Anhydride 108-24-7 500ml 3222 A2 103714 Sulfuric acid, fuming 9014-95-7 500g 3222 A2 103723 Phosphorus tribromide 7789-60-8 100g 3222 A2 103724 Trifluoroacetic acid 76-05-1 100g 3222 A2 101342 Succinyl chloride 543-20-4 3222 A2 100069 Chloroacetyl chloride 79-04-9 100ml 3222 A2 10002 Chloroacetyl chloride 79-04-9 100ml 3222 A2 101134 Acetyl chloride 75-36-5 500g 3222 A2 103721 Ethyl chlorooxoacetate 4755-77-5 100g 3222 A2 100423 Titanium(IV) chloride solution 7550-45-0 100ml 3222 A2 103877 Acetic Anhydride 108-24-7 1L 3222 A3 103874 Polyphosphoric acid 8017-16-1 1kg 3222 A3 103695 Chlorosulfonic acid 7790-94-5 100g 3222 A3 103694 Chlorosulfonic acid 7790-94-5 100g 3222 A3 103880 Methanesulfonic acid 75-75-2 500ml 3222 A3 103883 Oxalyl chloride 79-37-8 100ml 3222 A3 103889 Thiodiglycolic acid 123-93-3 500g 3222 A3 103888 Tetrafluoroboric acid 50% 16872-11-0 1L 3222 A3 103886 Tetrafluoroboric acid 50% 16872-11-0 1L 3222 A3 102969 sulfuric acid 7664-93-9 500 mL 2428 A7 102970 hydrochloric acid (37%) 7647-01-0 500 mL 2428 A7 102971 hydrochloric acid (37%) 7647-01-0 500 mL 2428 A7 102973 formic acid (88%) 64-18-6 500 mL 2428 A7 102974 hydrofloric acid (49%) 7664-39-3 500 mL 2428 A7 103320 Ammonium Hydroxide conc. -
Development of Novel Peptide Nucleic Acids A
b-Dicarbonyl compounds Compounds having two carbonyl groups separated by an intervening carbon atom are called b-dicarbonyl compounds, and these compounds are highly versatile reagents for organic synthesis. O O O O C C C R C C C OR' b b b-Dicarbonyl system b-Keto ester ** The pKa for such a proton is in the range 9-11, acidic enough to be removed easily by an alkoxide base to form an enolate. O O O H O OR C C C C C.. C + HOR H enolate anion pKa = 9-11 .. .. .. .. .. .. O . O . O O . O O C C C .. C C C R C OR' R C OR' R C OR' H H H Resonance structure of the anion of a b-keto ester Synthesis of b-keto ester (Claisen condensation) O O O NaOC H 2 2 5 CH3COC2H5 CH3CC..HCOC2H5 + C2H5OH + Na (removed by distillation) Sodiumacetoacetic ester HCl O O CH3CCH2COC2H5 Ethyl acetoacetate (acetoacetic ester) (76%) O O O O (1) NaOC2H5 R CH C + H CHC R CH2C CHCOC H + C H OH 2 OC2H5 OC2H5 + 2 5 2 5 (2) H3O R R (R may also be H) b-Keto ester Mechanism Step1 .. O O . .. + . OHC H + C H OH R CHC OC2H5 .. 2 5 RC.. H C OC2H5 2 5 H .. O . RCH C OC2H5 Step 2 .. .. .. .. O . O O O . RCH2C + . RCH2C CH C OC2H5 HC C OC2H5 . C H O . OC2H5 R 2 5 .. R .. O . O .. + . OC2H5 RCH2C CH C OC2H5 .. R Step 3 .. .. O . O H O O . -
The Use of Animal Models in Diabetes Research
Journal of Analytical & Pharmaceutical Research A Comprehensive Review: The Use of Animal Models in Diabetes Research Abstract Review Article Diabetes, a lifelong disease for which there is no cure yet. It is caused by reduced Volume 3 Issue 5 - 2016 production of insulin, or by decreased ability to use insulin. With high prevalence of diabetes worldwide, the disease constitutes a major health concern. Presently, it is an incurable metabolic disorder which affects about 2.8% of the global Iksula Services Pvt. Ltd, India population. Fifty percent of all people with Type I diabetes are under the age of 20. Insulin-dependent diabetes accounts for 3% of all new cases of diabetes *Corresponding author: Reena Rodrigues, Iksula Services each year. Hence, the search for compounds with novel properties to deal Pvt. Ltd, Mumbai, Maharashtra, India, Tel: 022-25924504; with this disease condition is still in progress. Due to time constrains, the use Email: of experimental models for the disease gives the necessary faster. The current review has attempted to bring together all the reported models, highlighted their Received: November 14, 2016 | Published: December 12, short comings and drew the precautions required for each technique. In Type 1 2016 or Diabetes mellitus, the body is unable to store and use glucose as an energy source effectively. Type 2 or diabetes insipidus is a heterogeneous disorder. In this review article we shall bring light as to how hyperglycemia, glucosuria and hyperlipidemia play an important role in the onset of diabetes. Keywords: Diabetes mellitus; Hyperglycemia; Diabetes insipidus; insulin Abbreviations: STZ: Streptozotocin; DNA: Deoxyribonucleic Acid; NAD: Nicotinamide Adenine Dinucleotide; GTG: Gold research. -
Toxicological Review of Chloral Hydrate (CAS No. 302-17-0) (PDF)
EPA/635/R-00/006 TOXICOLOGICAL REVIEW OF CHLORAL HYDRATE (CAS No. 302-17-0) In Support of Summary Information on the Integrated Risk Information System (IRIS) August 2000 U.S. Environmental Protection Agency Washington, DC DISCLAIMER This document has been reviewed in accordance with U.S. Environmental Protection Agency policy and approved for publication. Mention of trade names or commercial products does not constitute endorsement or recommendation for use. Note: This document may undergo revisions in the future. The most up-to-date version will be made available electronically via the IRIS Home Page at http://www.epa.gov/iris. ii CONTENTS—TOXICOLOGICAL REVIEW for CHLORAL HYDRATE (CAS No. 302-17-0) FOREWORD .................................................................v AUTHORS, CONTRIBUTORS, AND REVIEWERS ................................ vi 1. INTRODUCTION ..........................................................1 2. CHEMICAL AND PHYSICAL INFORMATION RELEVANT TO ASSESSMENTS ..... 2 3. TOXICOKINETICS RELEVANT TO ASSESSMENTS ............................3 4. HAZARD IDENTIFICATION ................................................6 4.1. STUDIES IN HUMANS - EPIDEMIOLOGY AND CASE REPORTS .................................................6 4.2. PRECHRONIC AND CHRONIC STUDIES AND CANCER BIOASSAYS IN ANIMALS ................................8 4.2.1. Oral ..........................................................8 4.2.2. Inhalation .....................................................12 4.3. REPRODUCTIVE/DEVELOPMENTAL STUDIES ..........................13 -
Chemical Resistance List
Chemical Resistance List Resistance Substance Permeation Time/Level to Degradation Fluoro- natural chloro- nitrile/ nitrile carbon butyl latex prene chloroprene rubber NR CR CR NBR FKM IIR NR NR CR CR NBR NBR NBR NBR NBR FKM IIR IIR NBR NBR 395 450, 451 720, 722 717 727 730, 732 740, 741 743 754 764 890 897 898 chemical physical 403 706 723, 725 733, 836 742, 757 state 708 726 736 - 739 759 - 0 - 0 0 + 1-methoxy-2-propanol paste 4 2 2 3 4 4 B 1 3 4 6 6 - 0 - 0 0 + 1-methoxy-2-propyl acetate liquid 3 1 1 3 3 A B 2 3 6 6 - 0 0 - 0 + 1-methyl-2-pyrrolidone liquid 5 2 3 3 3 2 A B 1 3 3 6 6 - 0 + + + - 1,1,2-trichlorotrifluoroethane liquid 1 0 5 4 6 6 1 1 2 1 6 1 2 - - - - - - 1.2-epoxy ethane (ethylene oxide) liquid B A A A A 0 0 0 B 1 2 - - - - - - 1.2-epoxy propane (propylene oxide) liquid B A A A 1 A 0 0 0 B 1 2 + + + + + + 1.2-propanediol liquid 6 6 6 6 6 6 6 6 6 6 6 6 6 - + - + + 0 2-ethyl hexyl acrylate liquid 2 1 1 5 6 1 1 2 6 2 3 - 0 0 0 + + 2-mercaptoethanol liquid 3 2 4 4 4 4 1 1 3 6 6 6 - - - 0 0 - 2-methoxy-2-methyl propane liquid 1 B B 2 4 A 1 4 1 3 2 2 - - - - - 0 3-hexanone liquid 1 B 1 1 1 0 0 0 0 0 3 3 - - - - - 0 4-heptanone liquid 1 A 1 1 1 A 0 0 0 B 3 3 - - - - - + acetaldehyde liquid 1 1 1 1 B 0 0 0 A 0 6 6 0 0 0 - - + acetic acid anhydride liquid 6 3 3 3 3 2 A B 1 B 2 6 6 + + + + + + acetic acid, 10 % liquid 6 6 6 6 6 6 6 6 6 6 6 6 6 0 + + + + + acetic acid, 50 % liquid 5 4 6 6 6 2 4 6 6 6 6 - - - - 0 + acetic acid, conc. -
Study on Accurate Determination of Volatile Fatty Acids in Rumen Fluid
5th International Conference on Information Engineering for Mechanics and Materials (ICIMM 2015) Study on Accurate Determination of Volatile Fatty Acids in Rumen Fluid by Capillary Gas Chromatography Cheng LUOa, Suyi CAI, Linyan JIA, Xiang TANG, Ruinan ZHANG, Gang JIA, Hua LI, Jiayong TANG, Guangmang LIU, Caimei WU*b Institute of Animal Nutrition, Key Laboratory for Animal Disease-Resistance Nutrition of Sichuan Province, Key Laboratory for Animal Disease-Resistance Nutrition and Feedstuffs of China Ministry of Agriculture, Sichuan Agricultural University, cheng’du 611130, China aemail: [email protected], *bemail:[email protected] Key Words: Capillary gas chromatography; Rumen fluid; Volatile fatty acids; Internal standard method Abstract. In order to obtain accurate results of volatile fatty acids (VFAs) in rumen fluid by capillary gas chromatography (GC), a pretreatment method was firstly conducted by dissolving VFAs in the methanol. An internal standard method (ISM) with crotonic acid as the internal standard was adopted in the detection. The results showed that the reproducibility of VFA (acetic acid, propanoic acid and butyric acid) was enhanced remarkably with methanol added as the solvent. The reproducibility was dependent on both of the VFA concentration and methanol amount. In conclusion, methanol solvent was more suitable than aqueous solvent for VFA accurate detection with ISM by capillary GC. Introduction Volatile fatty acids (VFAs) got through rumen fermentation were important energy sources for ruminant animals [1]. The acetic acid, propanoic acid, butyric acid accounted for about 95% of the total VFAs. Therefore, it was significant to determine acetic acid, propanoic acid and butyric accurately for the rumen fermentation study. In recent years, acetic acid, propanoic acid and butyric acid were detected by GC with packed column or capillary column [1-12]and ion chromatography (IC) [13]. -
Lonza's Chemical Network Diketene and HCN Derivatives, Heterocycles
Lonza’s chemical network Diketene and HCN derivatives, heterocycles and basic chemicals catalog Pharma&Biotech Nutrition Agriculture MaterialsScience PersonalCare Diketene and HCN derivatives, heterocycles and basic chemicals catalog Content About Lonza 3 Introduction 4 Diketene / ketene derivatives 6 Esters 6 Arylides 7 Alkylamides 8 Pyrazolones 9 Dehydroacetic acid 9 Lonzamon monomers 10 Other diketene derivatives 10 HCN derivatives 12 Heterocycles 14 Basic chemicals 16 Others 17 Alphabetical index 18 About Lonza Lonza is the global leader in the production and support of active phar- From 1897 to the present day combining Swiss tradition with global maceutical ingredients both chemically and biotechnologically. Biophar- experience, the company has had an enterprising character, adapting maceuticals are one of the key growth drivers of the pharmaceutical and its offerings and services to the needs of customers and to changing biotechnology industries. technologies. Throughout our history, we have maintained a strong culture of performance, results and dependability that is valued by all Lonza has strong capabilities in large and small molecules, peptides, of our customers. amino acids and niche bioproducts which play an important role in the development of novel medicines and healthcare products. In addition, Lonza’s cracker in Visp is the back bone of a comprehensive fully back- Lonza is a leader in cell-based research, endotoxin detection and cell ward integrated chemical network. Our product portfolio consists of therapy manufacturing. Furthermore, the company is a leading provider HCN- and diketene derivatives as well as basic chemicals which are key of chemical and biotech ingredients to the nutrition, hygiene, preserva- raw materials and intermediates for many sophisticated applications. -
Synthetic Turf Scientific Advisory Panel Meeting Materials
California Environmental Protection Agency Office of Environmental Health Hazard Assessment Synthetic Turf Study Synthetic Turf Scientific Advisory Panel Meeting May 31, 2019 MEETING MATERIALS THIS PAGE LEFT BLANK INTENTIONALLY Office of Environmental Health Hazard Assessment California Environmental Protection Agency Agenda Synthetic Turf Scientific Advisory Panel Meeting May 31, 2019, 9:30 a.m. – 4:00 p.m. 1001 I Street, CalEPA Headquarters Building, Sacramento Byron Sher Auditorium The agenda for this meeting is given below. The order of items on the agenda is provided for general reference only. The order in which items are taken up by the Panel is subject to change. 1. Welcome and Opening Remarks 2. Synthetic Turf and Playground Studies Overview 4. Synthetic Turf Field Exposure Model Exposure Equations Exposure Parameters 3. Non-Targeted Chemical Analysis Volatile Organics on Synthetic Turf Fields Non-Polar Organics Constituents in Crumb Rubber Polar Organic Constituents in Crumb Rubber 5. Public Comments: For members of the public attending in-person: Comments will be limited to three minutes per commenter. For members of the public attending via the internet: Comments may be sent via email to [email protected]. Email comments will be read aloud, up to three minutes each, by staff of OEHHA during the public comment period, as time allows. 6. Further Panel Discussion and Closing Remarks 7. Wrap Up and Adjournment Agenda Synthetic Turf Advisory Panel Meeting May 31, 2019 THIS PAGE LEFT BLANK INTENTIONALLY Office of Environmental Health Hazard Assessment California Environmental Protection Agency DRAFT for Discussion at May 2019 SAP Meeting. Table of Contents Synthetic Turf and Playground Studies Overview May 2019 Update ..... -
Study of Various Aqueous and Non-Aqueous Amine Blends for Hydrogen Sulfide Removal from Natural Gas
processes Article Study of Various Aqueous and Non-Aqueous Amine Blends for Hydrogen Sulfide Removal from Natural Gas Usman Shoukat , Diego D. D. Pinto and Hanna K. Knuutila * Department of Chemical Engineering, Norwegian University of Science and Technology (NTNU), 7491 Trondheim, Norway; [email protected] (U.S.); [email protected] (D.D.D.P.) * Correspondence: [email protected] Received: 8 February 2019; Accepted: 8 March 2019; Published: 15 March 2019 Abstract: Various novel amine solutions both in aqueous and non-aqueous [monoethylene glycol (MEG)/triethylene glycol(TEG)] forms have been studied for hydrogen sulfide (H2S) absorption. The study was conducted in a custom build experimental setup at temperatures relevant to subsea operation conditions and atmospheric pressure. Liquid phase absorbed H2S, and amine concentrations were measured analytically to calculate H2S loading (mole of H2S/mole of amine). Maximum achieved H2S loadings as the function of pKa, gas partial pressure, temperature and amine concentration are presented. Effects of solvent type on absorbed H2S have also been discussed. Several new solvents showed higher H2S loading as compared to aqueous N-Methyldiethanolamine (MDEA) solution which is the current industrial benchmark compound for selective H2S removal in natural gas sweetening process. Keywords: H2S absorption; amine solutions; glycols; desulfurization; aqueous and non-aqueous solutions 1. Introduction Natural gas is considered one of the cleanest forms of fossil fuel. Its usage in industrial processes and human activities is increasing worldwide, providing 23.4% of total world energy requirement in 2017 [1]. Natural gas is half of the price of crude oil and produces 29% less carbon dioxide than oil per unit of energy output [2].