Anti-Keratin Type II Monoclonal Antibody, Clone Ltqbo 2-9 (DMAB6594) This Product Is for Research Use Only and Is Not Intended for Diagnostic Use

Home , Cytokeratin, Keratin 6B, Type II keratin

Anti-Keratin Type II monoclonal antibody, clone Ltqbo 2-9 (DMAB6594) This product is for research use only and is not intended for diagnostic use.

PRODUCT INFORMATION

Product Overview Monoclonal Antibody to Keratin Type II

Antigen Description Cytokeratins, a group of at least 29 different proteins, are characteristic of epithelial and trichocytic cells. Cytokeratins 4, 5, 6 and 8 are members of the type II neutral-to-basic subfamily. Cytokeratin peptide 4 (59 kDa) is the secondary type II keratin expressed in non cornified stratified squamous epithelia. Cytokeratin peptide 5 (58 kDa) is the primary type II keratin in stratified epithelia, while cytokeratin type 8 (52 kDa) is a major type II keratin in simple epithelia. Cytokeratin 6 (56 kDa) is a "hyperproliferation" cytokeratin expressed in tissues with natural or pathological high turnover. Cytokeratins 10, 13 and 18 are members of the type I acidic subfamily. Cytokeratin peptide 10 (56 kDa) is the secondary type I keratin expressed in cornified epithelia. Cytokeratin 13 (54 kDa) is the secondary type I keratin expressed in non-cornified stratified squamous epithelia. Cytokeratin 18 (45 kDa) is the primary type I keratin expressed in simple epithelial cells.

Specificity Lt qbo 2-9 represents an excellent marker for distinguishing carcinomas from non-epithelial tumors. Polypeptides reacting: Mr 52 500 - Mr 68 000 keratins (type II keratins K1 - K8; formerly also designated cytokeratins 1-8) of human epithelial cells. Tumors specifically detected: all epithelium-derived neoplasms.

Immunogen Cytoskeletal proteins from cultured human MCF-7 cells.

Isotype IgG2a

Source/Host Mouse

Species Reactivity Human

Clone Ltqbo 2-9

Purification Protein A affinity chromatography

Conjugate Unconjugated

Applications IF

Size 1 ea

45-1 Ramsey Road, Shirley, NY 11967, USA Email: [email protected]

Storage Store at 2-8℃; for longer storage aliquots should be kept at -20℃.

BACKGROUND

Introduction Type II keratins (or Type II cytokeratins) constitutes the Type II intermediate filaments (IFs) of the intracytoplasmatic cytoskeleton, which is present in all mammalian epithelial cells. The type 2 cytokeratins consist of basic or neutral, high molecular weight proteins which in vivo are arranged in pairs of heterotypic Type I and Type II keratin chains, coexpressed during differentiation of simple and stratified epithelial tissues. Type II cytokeratins are encoded on chromosome 12q and encompasses: CK1, CK2, CK3, CK4, CK5, CK6, CK7 and CK8. Their molecular weight ranges from 52 kDa (CK8) to 67 kDa (CK18).

Keywords KRT6B; keratin 6B; K6B; PC2; CK6B; CK-6B; KRTL1; keratin, type II cytoskeletal 6B; keratin-6B; cytokeratin 6B; cytokeratin-6B type-II keratin Kb10; keratin, epidermal, type II, K6B keratin-like 1 (a type II keratin sequence); KRT6A; keratin 6A; K6A; K6C; K6D; CK6A; CK6C; CK6D; KRT6C; KRT6D; keratin, type II cytoskeletal 6A; cytokeratin 6A; cytokeratin 6C; cytokeratin 6D; type-II keratin Kb6; keratin, epidermal type II, K6A; keratin 6C; keratin 6D; Keratin, type II cytoskeletal 6A; Cytokeratin-6A; Cytokeratin-6D; Keratin-6A; Allergen Hom s 5; Keratin K6; Keratin Type II; Type II cytokeratins

GENE INFORMATION

Entrez Gene ID 3848

UniProt ID P04264

45-1 Ramsey Road, Shirley, NY 11967, USA Email: [email protected]