IN THE BREST-IROISE SCIENCE PARK A 2000 M2 PURPOSE-BUILT BUILDING FOR BIOTECHNOLOGIES
AVAILABLE FOR SALE OR RENT
www.batiment-biotech-brest.net
AVAILABLE FOR SALE OR RENT ON THE BREST-IROISE SCIENCE PARK SITE
Contents
OVERVIEW 4-5 LABORATORIES 6-7 BL1 LABS 8-9 BL2 LABS 10-11 BL3 LABS 12-13 SERVICE AREAS 14-15 SERVICE FLOOR 16-17 BASEMENT SERVICE AREA 18-19 REFRIGERATION AND POWER AREA 18-19 LOGISTICS AREA 20-21 A superb view of Brest bay OFFICES 20-21 from the building’s top fl oor lobby PLAN 22-23 CROSS-SECTION 24-25 SURROUNDINGS 26-27 SCIENTIFIC SURROUNDINGS 28-29 GEOGRAPHICAL SURROUNDINGS 30-31 CONTACT US 33
APPENDIX BL2 LABORATORY BLOCK DIAGRAM 37 DETAILED PLAN OF BL2 LABORATORIES 39 BL3 LABORATORY BLOCK DIAGRAM 41 DETAILED PLAN OF BL3 LABORATORIES 43
3 The bay and Crozon peninsula seen from the building
4 www.batiment-biotech-brest.net
AVAILABLE FOR SALE OR RENT ON THE BREST-IROISE SCIENCE PARK SITE
Overview
Brest’s Urban Council proposes a recently-designed building devoted to biotechnologies con- taining 6 BL3 labs and 16 BL2 labs in scientifi c surroundings, on the Brest-Iroise science park site.
This multipurpose complex of 2000m2 is available immediately for sale or for rent. It is adapted General view of building to every sort of GLP or GMP biotechology activity: - manufacturing, inspecting, testing… - pharmaceutical, veterinary, cosmetic and other products.…
Its design makes shared occupancy possible between several organisations or companies.
Designed to the latest standards, the building provides
- a high degree of functionality : South side of building - for use : at the heart of an entirely wired building, the laboratories are framed by function- specifi c areas: - logistics, - service - offi ces (see plan p23) - for maintenance : all maintenance related to the fi ltering, HVAC and effl uent elimination systems is done outside of the laboratories, thanks to a service fl oor and basement service area (see cross section p25) - high levels of self-suffi ciency for power, entry authorisation and management.
5 380 and 220 Volt electrical power supply, mains and backup Access to changing rooms: through green door and to BL3 labs: through red doors
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Laboratories
2 rooms are ready for use in a BL1 type activity. (see plan p23)
The separate unit housing the 22 BL2 and BL3 laboratories at the heart of the building is framed by the service areas, logistics area and offi ces.
They have been particularly well equipped. The lab benches are made of Corian and have a built-in sink connected to the kill tank. The wall surfaces are covered with PET.
The electrical supply is generously designed: 380V, 220V mains, 220V UPS, 220 V backup.
The phone and computer networks provide links between each laboratory and the rest of the building. Extract from the plan
A central system can record and control the access, as well as the temperature and pres- sure parameters in these confi ned premises.
Laminar fl ow fume hood - Large observation windows onto the semi-clean corridor - Ease of movement and access to fi ltering equipment, fi ltres, power blowers
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BL1 labs
2 adjoining rooms of 75 m2 (see plan p23) are ready equipped for a BL1 type activity: - 220 volt electric current, mains and UPS, - computer wiring, - hot and cold water inlets and outlets, - wastewater collection
The layout of the premises makes it easy to install an air-conditioning system.
2 BL1-ready rooms in the East offi ce area
BL1 Lab: inside view
9 Airlock entry to a BL2 lab The 2 autoclaves in the BL2 section Laminar flow fume hood - Large observation windows onto the semi-clean corridor area
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BL2 labs
The fi fteen 20m2 labs and the 40 m2 lab each have 3 rooms: airlock entry, laboratory and airlock exit.
They are entered via a «clean corridor». Exits are made via a «semi-clean corridor», guaranteeing the one-way workfl ow principle.
Thanks to the airlocks, there is no air fl ow between the working room and the corridors. (see plan p23)
Two double-doored autoclaves located at the end of the semi-clean corridor can process the waste from these laboratories. BL2 lab measuring 40m2 Some of the labs have a CO2 supply
All maintenance can be done from the service fl oor and the basement service area (See cross section p25)
Each laboratory has an air treatment plant to: - fi lter the input air, - maintain pressure gradients between the compartments, - maintain a constant temperature
Using the latest technology, like the rest of the facilities, the plants adapt to pressure drops caused by fi ltering in real time.
Corridor leading to BL2 labs The fresh air is pretreated and its humidity stabilised in a shared plant. The exhaust air is fi ltered before being released into the natural environment.
Voir en annexe : BL2 laboratory block diagram (p37) 11 Detailed plan of BL2 laboratories (p39) Coving throughout the building One of 2 corridors leading to BL3 labs and equipment airlock
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BL3 labs
Each one of these 6 laboratories is compliant with BL3 standards. They are made up of 3 rooms (see detailed plan p43) : a shower airlock, an airlock for personnel and the laboratory itself. A system of latches guarantees the sequence of movements.
Each laboratory also has: - an equipment airlock - a double-doored autoclave located between the laboratory and the «semi-clean corridor» - a laminar fl ow fume hood - connection to the CO2 network
All maintenance can be done from the service fl oor and the basement service area. Observation window - CO² inlet - Fume hood - Autoclave Each laboratory has a totally separate air treatment plant (see BL3 block diagram p41). This makes it possible to ensure constant pressure gradients between the laboratory’s different com- partments.
Each laboratory is supplied with only fresh air.
This air is fi ltered and its temperature and humidity are stabilised .
Using the latest technology, like the rest of the facilities, the plants adapt to pressure drops cau- sed by fi ltering in real time.
The exhaust air is fi ltered before being released into the natural environment.
Semi-clean corridor: autoclave outlet and observation windows
Voir en annexe : BL3 laboratory block diagram (p41) 13 Detailed plan of BL3 laboratories (p43)
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Service areas
The building was designed so that the service functions actually «serve» the «Laboratory» areas. They are located in such a way that service operations are optimised.
The refrigeration and power area is outside
The air treatment systems are set up in a walk-on ceiling service fl oor area
The networks for fl uid circulation and treating of effl uents are located in the basement
Air treatment installations in the service fl oor
Separate wastewater networks: storm drainage, laboratory and autoclave effl uents – CO² supply
15 Footbridge access from the car park (100 spaces) The boiler room
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Service floor
The 7 air treatment plants in the BL3 area, one per laboratory and one for the outbuildings, as well as the 19 plants in the BL2 zone are located directly above the laboratories. (see BL2 block diagram p37 and BL3 block diagram p41)
Amongst other things, it includes: - the boiler room, the electrical distribution station, a storage area and the computer room.
A footbridge from it leads to a large car park for staff.
To the south, a sweeping mezzanine overlooking the mouth of the bay provides access to two terraces. Dual air-recovery system Ease of movement and access to equipment
The mezzanine: view of the bay and access to terraces
See appendix: BL2 laboratory block diagram (p37) 17 BL3 laboratory block diagram (p41) Kill tank: caustic, acid and other treatment tanks
The power generator set, transformer and refrigeration units
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Basement service area
It provides access to each laboratory. It holds the fl uid networks for: - water supply: - soft water, hot water loop, - wastewater: - from the laboratories (polypropylene pipes), - from the autoclaves (cast iron pipes) - and special gases.
It holds an effl uent treatment plant called a kill tank restoring neutral pH water.
3 separate wastewater networks: storm drainage, laboratory and autoclave effl uents – CO² supply Refrigeration and power area
The building’s electrical power supply includes its own electric transformer, a 250 KVA electric power generator and UPS surge protection for the computer systems.
Two refrigeration units provide a cold production capacity of 172.2 KW each.
Heating and the hot water loop supply are provided by two 345 KW gas-powered boilers
Refrigeration units with back-up - EDF utility-approved transformer - Power Generator 19 Storage area for special gases
Bayside view The reception area and access to the upper lobby
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Logistics area
This is made up of a temperature controlled reception area accessed via a 3 m wide roll-up door, storage areas, a room to store liquid nitrogen and an offi ce.
Three outdoor premises complement the zone for storage and distribution of special gases, storage of chemcial products and storage of waste.
Reception area for goods Offices
The 800 m2 of offi ce space directly overlooking the sea are made up of two separate platforms.
Each holds two individual offi ces with 40 m2 of fl oor space.
The East platform has two BL1-ready rooms.
Two 60 m2 meeting rooms complete the facility.
One of 2 column-free offi ce spaces
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Plan
Each function has been assigned a specifi c zone to make operations and maintenance easier.
In grey: the logistics area In yellow: the «laboratories» section In blue: the «offi ces» section
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Cross-section
The laboratories are at the heart of the building.
In grey: the logistics area In yellow: the «laboratories» section In blue: the «offi ces» section
25 Bridges over the Elorn river, Brest’s bay and narrows Brest, the city of the sea
Brest, top ranking ship repair site in France The castle and the military harbour
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Surroundings
Brest, a regional capital with 220,000 inhabitants
Brest, maritime city on the Atlantic, is located on a vast 150 km2 bay.
This area with a population of 380,000 enjoys the benefi ts of big-city life such as: the University, the Regional University Hospital Centre, the airport, an exciting cultural life and a full range of sporting activities.
The regional economy Siam high street Defence activities and industries are its mainstay. Other development orientations mainly include: maritime technologies and industries, electronics, information technology and telecommunications, mechanics, agri-business and life science technologies.
Technology – Defence: Thales radar antenna
27 Interactive modelling of coagulation phenomenon
ESMISAB (Brest graduate engineering school for microbio- logy and food safety)
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Scientific surroundings
Research and higher education
There are 2,500 people employed in research fi elds in Brest. It’s the top-ranking European centre for marine sciences, as well as a major centre for the Information technology sector.
The vitality of Brest’s life science sector is best seen in agribusiness and the fi eld of medicine (a faculty of medicine associated with the CHR - 2 INSERM labs: working with the ENSTB in genetics and medical imaging, etc.)
Research on hydrothermal bacteria is carried out by Ifremer. Investigations in bioinformatics on blood coagulation and myeloma are conducted by the European centre for Virtual Reality at the ENIB. Ifremer’s Nautile submersible
Higher education
Brest has over 23,000 students, notably in 6 UBO University of western Brittany research depart- ments and 7 engineering schools.
Several courses of study provide training in biotechnology: 2 IUT degrees in biological engineering with a «biological and biochemical analyses option», a master’s degree in cellular biology and in physiology and the ESMISAB graduate school of microbiology and food safety.
This diversifi ed array of training possibilities not only meets young people’s expectations, but also provides a pool of human resources and brain power for companies.
The university restaurant and the IUEM
29 The science park site, bay and city / drawing by N. Huchard Brest in Europe
The area located 30-40 min from Brest Getting to Brest Iroise science park
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Geographical surroundings
An outstanding site
The Biotech building is set up on the Brest-Iroise science park, an exceptional site on the sea- front. It overlooks the entrance to the bay of Brest, facing the Pointe des Espagnols headland on Crozon peninsula. 4,500 people work in the companies, research centres and insitutions of higher education found in the technopole science park.
Getting there
The international activity of large fi rms, many SMEs and public bodies explains the frequent air connections : The Biotech building overlooks the bay - 10 round trip fl ights daily to Orly and Roissy airports in Paris, with on-going fl ights to 63 European cities in the morning.
Brest can also be reached by TGV very high speed train service (Paris-Brest in 4 hours) and two toll-free motorways from: Nantes/Bordeaux and Rennes/Paris.
Brest - Paris (Montparnasse station) in 4 hours
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Contact us
Brest metropole oceane Economic Development Division 24 rue Coat ar Guéven BP 92242 – 29222 Brest cedex 2 tel : 33 (0)2 98 33 50 47 [email protected] tel : 33 (0)2 98 33 52 33 [email protected] tel : 33 (0)2 95 49 81 93
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APPENDIX
35
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BL2 laboratory block diagram
37
www.batiment-biotech-brest.net
AVAILABLE FOR SALE OR RENT ON THE BREST-IROISE SCIENCE PARK SITE
Detailed plan of BL2 laboratories
39
www.batiment-biotech-brest.net
AVAILABLE FOR SALE OR RENT ON THE BREST-IROISE SCIENCE PARK SITE
BL3 laboratory block diagram
41
www.batiment-biotech-brest.net
AVAILABLE FOR SALE OR RENT ON THE BREST-IROISE SCIENCE PARK SITE
Detailed plan of BL3 laboratories
43