Producing knowledge to cure disease 2018–2019 Annual Report

Feinstein Institutes for Medical Research Northwell Health® Contents 3 A message from Michael J. Dowling and Kevin J. Tracey, MD 4 Select 2018 grants received 6 Achievements 12 Feinstein Institutes 22 Research directory 53 Financial summary 54 A message from the Chair of the Board of Directors 55 Board of Directors 56 2018 Honor Roll

The mission of The Feinstein Institutes for Medical Research is to produce knowledge to cure disease.

2 Feinstein Institutes for Medical Research | 2018–2019 Annual Report Two thousand eighteen was a year of achievements that has set the pace for our continuing growth Our scientists made breakthrough discoveries in producing knowledge to cure disease. We’ve had remarkable results in treating lupus, endometriosis and post-partum depression, while also making advancements with technology to restore limb movement and decoding signals the nervous system uses to communicate immune status and inflammation to and from the brain. In pursuing these breakthroughs, we doubled the size of our grants portfolio since 2015, garnering more than $76 million in funding last year for work in our labs. Building on our strategic partnerships with marquee names such as GE and United Therapeutics, we forged a new, exciting scientific collaboration with Boston Scientific, and “spun out” Sanguistat, a new company seeking to bring the neural tourniquet to market, a bioelectronic therapy that treats bleeding in post-partum mothers and may have use in protecting soldiers from grievous wounds in combat. We continue to grow our cancer and neurological research in partnership with Cold Spring Harbor Laboratory. On the philanthropic front, we received more than $20 million in endowed gifts to the Feinstein Institute, including a gift from the Elmezzi Foundation for the Elmezzi Graduate School of Molecular Medicine, and a gift from the Karches Family Foundation to support distinguished chair positions. Our growth as a major scientific institute and the home of research for the entire Northwell Health system is dramatic, fast and very exciting. To best manage it, we have embarked on a reorganization. Inspired by the National Institutes of Health, we are now known as The Feinstein Institutes for Medical Research at Northwell Health. The “new” Feinstein Institutes will be composed of five institutes led by internationally recognized leaders in their fields: Behavioral Science, led by John Kane; Bioelectronic Medicine, led by Yousef Al Abed; Cancer Research, led by Richard Barakat; Health Innovations and Outcomes Research, led by Tom McGinn; and Molecular Medicine, led by Betty Diamond. The five-institute structure gives us greater focus and accountability, and it allows us to tell our story simply and with power. With help from our board of directors and indispensable support from Northwell Health, we have laid the groundwork for great things to come in 2019 and beyond.

Michael J. Dowling Kevin J. Tracey, MD President and CEO President and CEO Northwell Health The Feinstein Institutes Northwell Health 3 Select 2018 grants received

Assistant Professor Monowar Aziz, PhD, received a $1.68 million R01 grant from the National Institutes of Health (NIH) to examine a protein’s role in increasing inflammation and injury in sepsis to develop new therapies. Dr. Aziz believes the key to a new treatment may be the mechanisms of inflammatory protein called extracellular cold-inducible RNA- binding protein (eCIRP).

Professor Todd Lencz, PhD, received a $2.75 million NIH grant to study cognitive genomics as a window on neurodevelopment and psychopathology. Because cognitive deficits are often the most disabling feature of mental illness, this research can provide critical insights into the treatment of schizophrenia, autism and other disorders.

Professor Michael A. Diefenbach, PhD, received a $3.5 million R01 grant from the NIH National Cancer Institute to develop a post-surgical care program for stage II bladder cancer patients and their caregivers. This is the first study to address the needs of bladder cancer patients and their caregivers with the goal of reducing infections and unplanned nurse/ER visits while improving their quality of life.

4 Feinstein Institutes for Medical Research | 2018–2019 Annual Report Professor Valentin A. Pavlov, PhD, received a $1.65 million R01 grant from the NIH to examine the vagus nerve’s role in the inflammation and metabolism associated with sepsis. Having a better understanding of the nervous system’s signaling during sepsis could lead to the identification of new therapeutic targets within the scope of bioelectronic medicine.

Assistant Professor Myoungsun Son, PhD, received a $2 million NIH National Institute of Allergy and Infectious Diseases (NIAID) grant to study mechanisms of polarization of monocytes by DAMPs/PAMPs and C1q. Dr. Son believes this study has implications for treating and preventing lupus and autoimmune disease and conditions on non-resolving inflammation.

Professor Larry Miller, MD, received a $1.4 million NIH grant to develop and test a non-invasive method that accesses nerves in the chest and abdomen. Gaining non-invasive access to these nerves has the potential to drive development of bioelectronic medicine devices for treatment of conditions like obesity, heart failure and pulmonary hypertension.

Northwell Health 5 Achievements

Grants –– Safiya Richardson, MD, was awarded a five-year, $850,000 NIH grant to Over the last three years, the Feinstein support her work in creating tools Institutes doubled extramural funding that help doctors make evidence- from $38 million to $76 million. In addition based clinical decisions. to the six awardees featured on the –– Loren Rieth, PhD, will collaborate with previous pages, our researchers received a global team of engineers, surgeons the following major grants and support in and medical researchers funded by 2018–2019. a $482,000 grant from the NIH Brain –– Catherine Benedict, PhD, was awarded Research through Advancing Innovative a five-year, $693,000 grant from the Neurotechnologies® (BRAIN) Initiative. National Institutes of Health (NIH) to The grant allows for the study of develop and test a digital health platform improved hearing treatment. to help young female cancer survivors Support evaluate their options for having children, make decisions and plan for the future. –– The Elmezzi Foundation provided a –– Lionel Blanc, PhD, received a five-year, $10 million endowed gift to the Elmezzi $2.5 million NIH grant to study improved Graduate School of Molecular Medicine, treatment for erythropoietic disorders, a PhD program for physicians who including Diamond-Blackfan anemia. wish to pursue careers in biomedical –– Chunyan Li, PhD, received a $1.3 million research. This is in addition to an existing research award from the U.S. Department $15 million gift, bringing the Elmezzi of Defense (DOD) to develop a novel Foundation’s contribution to $25 million. field resuscitation technology through –– Female Feinstein Institutes scientists trigeminal nerve stimulation (TNS), an received more than $300,000 in awards area of bioelectronic medicine. during the seventh annual Advancing –– Thomas G. McGinn, MD, was awarded by Women in Science and Medicine (AWSM the U.S. Department of Health & Human — pronounced “awesome”) luncheon Services Agency for Healthcare Research to celebrate and support excellence and and Quality (AHRQ) a three-year, $1.14 achievements of women in science. Since million grant for a clinical decision its inception, the organization has raised support system that reduces frontline more than $1 million to support female providers’ complications and frustrations. scientists. –– Renée Pekmezaris, PhD, received a $3.03 million research award from the Patient- Centered Outcomes Research Institute (PCORI) to study home telemonitoring for patients in the Hispanic community living with type 2 diabetes. This is Dr. Pekmezaris’ third PCORI award to develop a telemedicine program for underserved populations.

6 Feinstein Institutes for Medical Research | 2018–2019 Annual Report Members of the Office of Clinical Research Cynthia Aranow, MD

Clinical Research “Clinical Trial to Evaluate the Safety Publications & and Effectiveness of Using the Tendyne –– David Bernstein, MD, was ranked Mitral Valve System for the Treatment Presentations number one nationwide for enrollment of Symptomatic Mitral Regurgitation Our researchers published 1,331 scientific in the Enanta Pharmaceuticals PBC trial (SUMMIT).” and clinical research papers in 2018 in the “EDP 305-201: A Phase 2 Dose Ranging, –– Gregory Maniatis, MD, served as the world’s leading journals. Randomized, Double Blind, Placebo- principal investigator for the Myocardial Controlled Study Evaluating the Safety, Ischemia and traNsfusion Trial (MINT) –– Meghan E. Addorisio, BS, Sangeeta Tolerability, Pharmacokinetics and sponsored by the National Heart, Lung S. Chavan, PhD, Kevin J. Tracey, MD, Efficacy of EDP-305 in Subjects with and Blood Institute, in which he enrolled and others from our bioelectronic Primary Biliary Cholangitis (PBC) with 50 patients in collaboration with Lenox medicine labs, with collaborators from or without an Inadequate Response to Hill Hospital and Southside Hospital. Academic Medical Center at University Ursodeoxycholic Acid (UDCA).” –– Michael Nett, MD, was the first to initiate of Amsterdam, conducted pilot clinical –– Joan DeCelie-Germana, MD, and Janice a clinical trial in the new Northwell studies using a novel non-invasive Wang, MD, collaboratively enrolled 63 Health Orthopedics service line. bioelectronic device that showed to patients in 16 cystic fibrosis clinical –– Northwell Health Cardiology is a Center improve disease symptoms in patients trials, and are the first Northwell Health of Excellence in Clinical Research and in with rheumatoid arthritis. The findings Certified Principal Investigators provided 2018 had 103 clinical trials, enrolled 556 were published in Bioelectronic Medicine. by the Association of Clinical Research new participants, and conducted clinical –– Cynthia Aranow, MD, presented pilot Professionals. trials across six Northwell hospitals. clinical trial results which found that –– Richard Furie, MD, ranked number one –– Michael Poon, MD, enrolled 395 patients a bioelectronic medicine device was nationwide for enrolling 15 participants in his three investigator-initiated projects effective in reducing pain and fatigue in a trial, ranked in the top five for where he has received funding from GE, in patients with lupus at the American enrolling 11 patients in another trial, and Canon and Heartflow. College of Rheumatology/Association of was the first to enroll patients in a phase –– Gil Scuderi, MD, ranked third in Rheumatology Professional’s (ACR/ARHP) 2 lupus trial. enrollment for the KCI USA, Inc.- Annual Meeting. –– Jeffrey Katz, MD, and Richard Libman, sponsored trial “Closed Incision Negative –– Betsy J. Barnes, PhD, found that MD, enrolled more than 35 patients, Pressure Therapy Versus Standard of Care hemophagocytes, a newly identified ranking second nationwide, in the Surgical Dressing in Revision Total Knee population of phagocytes, may have a Medtronic sponsored trial “Rate of Atrial Arthroplasty (PROMISES).” direct impact on patients with a variety Fibrillation through 12 Months in Patients –– Varinder Singh, MD, and Nirav Patel, MD, of autoimmune diseases, and published with Recent Ischemic Stroke of Presumed were ranked second in the world for these findings in Science. Known Origin.” enrolling 28 patients in the NIH-funded –– Robert Kalimi, MD, and Larry Ong, MD, Hybrid trial. enrolled the first patient in the Northeast in the Abbot Vascular-sponsored Northwell Health 7 –– Sangeeta Chavan, PhD, Thomas R. –– Betty Diamond, MD, and colleagues –– Miji Kim, MD, and Anam Basharat, MD, Coleman, PhD, Adam M. Kressel, MD, discovered they can identify a person’s along with head of the Diabetes Research Tea Tsaava, MD, Kevin J. Tracey, MD, and risk for lupus by looking at the presence Laboratory, Jesse Roth, MD, examined the Stavros Zanos, MD, PhD, with GE Research and amount of antibodies and a protein latest data on nutrition and encouraged demonstrated potentially breakthrough complex in blood as published in the medical community to re-energize non-invasive methods to regulate Molecular Medicine. their recommendations on vitamins for dysfunction in the body’s metabolic or –– David Eidelberg, MD, and his team patient care as published in Diabetes & inflammatory control systems using uncovered that an emerging gene Metabolism: Research & Reviews. ultrasound. The findings were published therapy for Parkinson’s disease creates –– Chunyan Li, PhD, assistant in Nature Communications. new circuits in the brain associated professor, published a study in Critical –– Kristina M. Deligiannidis, MD, conducted with improved motor movement. The Care Medicine, the discovery that an integrated analysis of one phase 2 findings were published inScience stimulation of the trigeminal nerve can and two phase 3 clinical trials sponsored Translational Medicine. reverse hemorrhagic shock due to by Sage Therapeutics which found –– Mark Herceg, PhD, published a acute blood loss and improve survival that brexanolone injection 90 µg/ correspondence in The Lancet Neurology, in an animal model. This therapeutic kg/h demonstrated a reduction in asking for balance when reporting on approach, which is a form of bioelectronic depressive symptoms in women sports-related injury chronic traumatic medicine, could potentially represent a suffering from moderate and severe encephalopathy (CTE). CTE is a type of paradigm shift in the way that this deadly postpartum depression (PPD) compared dementia associated with exposure to condition is managed in the future. to placebo. Based on these findings, Sage repeated concussions, and has been –– Renee Pekmezaris, PhD, found that home Therapeutics applied for U.S. Food and linked with a variety of contact sports telemedicine programs for heart failure Drug Administration (FDA) approval of such as boxing, football, American are effective at preventing death for at brexanolone injection and, if approved, football and rugby. Dr. Herceg also least six months after hospitalization, it will be the first medication specifically presented at the 13th World Congress on but generally lose any benefit after one for the treatment of PPD. These findings Brain Injury in Toronto results of a study year. These findings were published in were published in The Lancet. on elite female youth ice hockey players Health Affairs. –– Betty Diamond, MD, found that the and their knowledge about concussions, –– Lucille Nichols Lee, MD, and Louis Potters, class of drugs commonly used to treat including how their behavior is influenced MD, identified methods to increase use hypertension, ACE inhibitors, can by their awareness. of the cutting-edge cancer radiation block cognitive decline in mice and therapy, hypofractionation, in breast might therefore be used to preserve cancer patients. These findings, published the memory of patients living with in Advances in Radiation Oncology, lupus as published in the Journal of demonstrate that most patients with Experimental Medicine. breast cancer can be treated with a type of radiation therapy that is as effective, but has lower toxicity levels, compared to current treatments.

Lior Brimberg, PhD, and Naomi Maria

8 Feinstein Institutes for Medical Research | 2018–2019 Annual Report call for the routine screening of intimate Alex C. Spyropoulos, MD partner violence only in women of and Celia Lu childbearing age. –– Rebecca Schwartz, PhD, found that exposure to natural disasters, such as Hurricane Harvey, are associated with increased stress and anxiety — data that will be used to better understand the mental health impact of future storms. These findings were presented during a roundtable discussion at the American Public Health Association annual meeting. –– Alex C. Spyropoulos, MD, uncovered an anticoagulant treatment strategy to reduce non-fatal blood clots and pulmonary embolism in acutely-ill hospitalized patients, as published in –– Todd Lencz, PHD, and Jian-Ping Zhang, The New England Journal of Medicine. MD, PhD, found that genetics can be This treatment strategy is associated used to predict a patient’s response with almost no critical or fatal bleeding to antipsychotic drug treatment for and with a very low incidence of schizophrenia, as published in the major bleeding. American Journal of Psychiatry. –– Joel N.H. Stern, PhD, with colleagues –– Naomi I. Maria, PhD, presented study at Rockefeller University, developed results at the American College a new understanding of how certain of Rheumatology/Association of psychiatric diseases — those that involve Rheumatology Health Professional’s uncontrollable reactions to stimuli (ACR/ARHP) Annual Meeting which such as the high and low experiences found in a mouse model that a human attributed to bi-polar disorder, the protein involved in activation of the impulsivity of an individual suffering immune system could cause pregnancy from attention deficit hyperactivity complications in women with lupus. disorder, and even suicidality — manifest This is the first step to developing new and potentially can be treated as therapies which could give hope to published in Proceedings of the National pregnant women with lupus — along Academy of Sciences (PNAS). with their unborn children. –– Kevin J. Tracey, MD, with leading –– Louis Potters, MD, demonstrated the scientists across Canada, Europe and Asia, safety and improved efficacy of increased discovered the critical role the chemical dosage of radiation when treating acetylcholine plays as a neurotransmitter prostate cancer, and published this in in combating chronic viral infection, and The International Journal of Radiation published this in Science. Oncology, Biology, Physics. –– Theodoros P. Zanos, PhD, and his –– According to an editorial published in collaborators were the first to decode the Journal of the American Medical specific signals the nervous system Association (JAMA) by Karin Verlaine uses to communicate immune status Rhodes, MD, MS, health systems need and inflammation to the brain, a major to expand the science around routine step forward for bioelectronic medicine screening and interventions for domestic as it provides insight into diagnostic abuse to include men, the elderly and therapeutic targets, and device and vulnerable populations. These development. These findings were recommendations were in response published in Proceedings of the National to the latest guidelines from the U.S. Academy of Sciences (PNAS). Preventative Services Task Force (USPSTF) released in the same issue of JAMA which

Northwell Health 9 –– The Feinstein Institutes, the Karolinska Maria Lopez and Loren Reith, PhD Institutet and its journal, the Journal of Internal Medicine, hosted “Bioelectronic Medicine: Technology Targeting Molecular Mechanisms,” in Stockholm, Sweden, which brought together leading researchers from neuroscience, molecular biology and bioengineering to discuss discoveries that drive the field of bioelectronic medicine forward. –– The Feinstein Institutes hosted a Marsh Lecture by Stanford University George A. Zimmerman Professor and Professor of Pediatrics Lawrence Steinman, MD. Dr. Steinman discussed his research into the role amyloid proteins play in slowing immune response in patients with multiple sclerosis (MS). –– The Feinstein Institutes and Center for NorthTrac, which was developed by the Partnerships & Programs Workforce Readiness named Hicksville Feinstein Institutes to help head and High School in Nassau County as the –– We improved our strategic partnership neck cancer patients manage their post- winner of its seventh annual Medical development pipeline with key partners treatment symptoms. Marvels competition. The Medical including Avanos, Boston Scientific, –– The 2018 Commencement Exercises for Marvels program encourages Long GE, Neurome, Sanguistat, United the Elmezzi Graduate School of Molecular Island high school students in 9th Therapeutics and others. Medicine and the presentation of two and 10th grades to pursue careers in –– Kevin J. Tracey, MD, and Martin honorary degrees took place on May 24 science, technology, engineering and Doerfler, MD, Northwell Health senior at the Feinstein Institutes. The honorary math (STEM). This year’s competition vice president, clinical strategy and degrees, which are given to researchers asked participants from 38 schools from development, and associate chief medical who advanced biomedical research four counties to develop a solution to officer, will play key roles in Connecticut- and improved medical treatment for curtail the prevalence of vaping on their based biotech company Sanguistat, Inc., patients, were presented to Mina respective school grounds. supporting the company’s mission to Bissell, PhD, distinguished scientist –– Jason Econome, a Stuyvesant High create bioelectronic medicine devices to in the Division of Biological Systems School science teacher and resident control bleeding. and Engineering at Lawrence Berkeley of Garden City, NY, spent the summer –– Andrew Galmer, DO, Mitchell Weinberg, National Laboratory, and Anthony Zador, at the Feinstein Institutes with lupus MD, and other members of the Sandra PhD, professor of biology and program scientist, Betty Diamond, MD, as part Atlas Bass Heart Hospital at North Shore chair for neuroscience at Cold Spring of The American Physiological Society’s University Hospital were the first in Harbor Laboratory. 2018 Frontiers in Physiology Research New York State — and among the first –– Entertainer Fergie took center stage Community Leaders Professional nationally — to treat a patient with a at the Feinstein Institutes Summer Development Fellowship program. new implantable device for uncontrolled Concert, which raised more than –– Olivia Frischman, 16 and a rising blood pressure as part of a recently- $3 million to support the Institutes’ junior from Westchester, NY, spent a launched clinical study. research initiatives. portion of her summer at Lenox Hill –– Lenox Hill Hospital and the Feinstein –– The Feinstein Institutes selected Baylor Hospital shadowing John Boockvar, MD, Institutes were selected as a study site College of Medicine’s Huda Zoghbi, neurosurgeon, director of the hospital’s to identify biomarkers for focal seizures MD, as the winner of the sixth annual Brain Tumor Center and professor at in patients with treatment-resistant Ross Prize in Molecular Medicine. The the Feinstein Institutes. Ms. Frischman epilepsy. Researchers hope the study, prize, which includes a $50,000 award, was inspired to pursue a career in called Human Epilepsy Project (HEP) 2, was presented to Dr. Zoghbi on June 5 neurosurgery after her father passed will help better understand the long- at the New York Academy of Sciences away from the most aggressive form of term challenges of living with focal (NYAS) in Manhattan, followed by brain cancer — glioblastoma multiforme seizures and better pinpoint severity and lectures from Dr. Zoghbi and other (GBM). treatment response. eminent researchers. The Ross Prize is –– Sewit Teckie, MD, and Michael A. awarded through the Feinstein Institutes’ Diefenbach, PhD, developed a pilot study peer-reviewed, open-access journal, that tests a new digital application, called Molecular Medicine.

10 Feinstein Institutes for Medical Research | 2018–2019 Annual Report Recognition & Honors Innovator of the Year awards by Innovate announced that the powerful and Long Island for their respective medical accessible automated 3D printing system –– In 2018, the Feinstein Institutes filed innovations in the fields of lupus research Form Cell has been incorporated into 29 patents. and telehealth options geared towards Northwell’s 3D Design and Innovation –– We distributed nearly 60 press releases the Spanish-speaking patient population. Center to increase production of generating 5 billion impressions, equating –– The “Fin” prosthesis won U.S. Food patient-specific anatomical models and to a publicity value of $2.4 million. and Drug Administration approval for surgical guides. Coverage included a CBS segment about general use. –– Members of the ACDS’ (formerly known Kelly Owens’ bioelectronic medicine –– Steven Gurien, MD, was honored by the as the Association for Children with experience, a Scientific American article Society of Critical Care Medicine (SCCM) Down Syndrome) DayHab Program about Dr. Theodoros Zanos’s research in with its Star Research Achievement in Plainview collected approximately decoding body-brain nerve signals, a BBC Award for his efforts to pinpoint specific 8,000 bottles and cans to raise money radio interview, which was picked up by molecules that can reduce inflammation to support Alzheimer’s research in the NPR, with Dr. Ona Bloom about her sea during sepsis. Litwin-Zucker Center for Alzheimer’s lamprey research, Dr. Meggan Mackay –– Bruce Volpe, MD, was recognized as Disease and Memory Disorders at the quoted in Self about lupus and Dr. a Heritage Healthcare Innovation Feinstein Institute. Kristina Deligiannidis quoted in Parents Award finalist, presented by Heritage –– David Eidelberg, MD, won the fourth about postpartum psychosis. Provider Network (HPN) and Crain’s annual Bachmann-Strauss Prize for –– Lance Becker, MD, and David Eidelberg, Custom Studio, a division of Crain’s New Excellence in Dystonia Research. MD, were elected into the Association of York Business, for his research using Dr. Eidelberg received an unrestricted American Physicians (AAP), a 134-year- technology to restore limb movement $100,000 grant for his use of innovative old society of the nation’s leading after neurological injury. brain imaging techniques and physician-scientists. Each year, clinicians –– Elmezzi Graduate School of Molecular computational algorithms to better are recognized by nomination for Medicine Scholar Gavin H. Imperato, MD, understand the pathophysiology of this membership by the AAP’s Council of the was named a Public Policy Fellow of the disorder and its treatment. Michael J. Fox Association. Their election gave them American Association of Immunologists and Todd Sherer, PhD, CEO of The Michael the opportunity to share their scientific (AAI) for 2018-2019. J. Fox Foundation for Parkinson’s Research discoveries and contributions with –– Elmezzi Graduate School of Molecular (MJFF), presented the prize at an MJFF their colleagues at the society’s annual Medicine Graduate Caroline Maloney, event in New York City. meeting. They join their previously MD, PhD, received The American –– Betty Diamond, MD, and her elected Feinstein Institutes colleagues, Pediatric Surgical Association’s (APSA) lab celebrated 10 years at the including Nicholas Chiorazzi, MD, M. Judah Folkman Memorial Award Feinstein Institutes. Betty Diamond, MD, Peter K. Gregersen, for her research in MD, John M. Kane, MD, Jesse Roth, MD, identifying a drug and Kevin J. Tracey, MD. that has the potential –– Chad Bouton joined leaders in to stop the spread of bioelectronic medicine to discuss osteosarcoma, the how nerve and brain implants can most common form of revolutionize treatment of disease childhood bone cancer. and debilitating injury during a –– Feinstein Institutes panel discussion at the 2018 BIO Professor Alex C. International Convention. Spyropoulos, MD, –– Karina Davidson, PhD, MASc, was earned the 2018 appointed as vice chair of the U.S. IPRO Quality Award Preventive Services Task Force. The Task for championing, Force is an independent, volunteer panel developing and of national experts in prevention and educating health evidence-based medicine. care professionals –– The Feinstein Institutes appointed Karina in anticoagulation W. Davidson, PhD, MASc, to lead a new management center, the Center for Personalized best practices. Health, focused on behavioral and –– Todd Goldstein, cardiovascular health research. PhD, Formlabs and –– Betty Diamond, MD, and Renee Northwell Health Pekmezaris, PhD, were presented

Northwell Health 11 The Feinstein Institutes

From left to right: David Battinelli, MD, Kevin J. Tracey, MD, and Ping Wang, MD

12 Feinstein Institutes for Medical Research | 2018–2019 Annual Report Back row, from left to right: Betty Diamond, MD, John Kane, MD, and Yousef Al-Abed, PhD Front row, from left to right: Thomas McGinn, MD, MPH, and Richard Barakat, MD

We are the home to five leading institutes in medical research — each with impressive track records of producing knowledge to cure disease and improve patients’ lives. Our researchers have made important discoveries in many medical fields, including cancer, sepsis, inflammation, autoimmune disorders, Parkinson’s disease, Alzheimer’s disease, schizophrenia and bioelectronic medicine.

Northwell Health 13 Director John Kane, MD, pictured right

Institute of Behavioral Science – Tackling debilitating mental health disorders

We are recognized as a world leader in research for effective treatments of debilitating mental health disorders. Our early treatment and comprehensive care programs for patients suffering from first-episode psychosis are national models of best practice research and care in the field.

The Institute of Behavioral Science leads and genetic markers for early identification the nation in research into intervention and treatment of mental health disease, and services for severe mental health and its work in using social media data disorders, including advancing new tools to generate early intervention strategies, and strategies for patient engagement, particularly with young people, are monitoring and clinical decision making recognized as leading the nation in for better care. A substantial portfolio of best practices. grants featuring federal government as At the heart of the institute is the Zucker well as private philanthropic support these Hillside Hospital, Northwell Health’s standard-setting efforts. The institute nationally recognized behavioral health Leading the field in runs a number of clinical trials not only center known for its pioneering clinical, advanced research and care to standardize outcome measurements teaching and research programs. The for schizophrenia, suicidal in psychiatric research but to ensure the National Institute of Mental Health has depression, addiction and translation of research into clinical practice. established a Clinical Research Center first-episode psychosis. The institute is known for pioneering for the Study of Schizophrenia at Zucker new treatments for schizophrenia and Hillside Hospital, one of only four such first-episode psychosis. Its most recent facilities nationwide. breakthroughs include using neuroimaging Director Yousef Al-Abed, PhD, pictured center

Institute of Bioelectronic Medicine – Using technology to treat disease and injury

We are the global, medical and scientific headquarters of bioelectronic medicine, where traditional approaches of treating disease are challenged through discoveries at the interplay of biology, engineering and medicine.

Bioelectronic medicine is a field of Our bioelectronic medicine scientists medicine that emerged from the Feinstein work to generate knowledge of the Institutes’ labs. It represents a convergence mechanisms of organ control by tapping of molecular biology, neuroscience and into neural pathways, develop technology bioengineering. Its two primary discoveries that delivers safe and effective therapies are, first, that inflammation is the central with fewer adverse effects, and rapidly phenomenon in virtually all disease, advance our knowledge into clinical from cancer to diabetes, and second, practice along a streamlined medical device inflammation can be controlled through the regulatory pathway. vagus nerve, the body’s main “highway” of One of the exciting aspects of bioelectronic Pioneering bioelectronic neural information that prompts and curbs medicine is its potential to supplement and medicine, which has the inflammation. even replace drugs, including their cost and potential to supplement The institute’s work in molecular biology often debilitating side effects. and even replace drugs, to fully understand the vagus system and significantly reducing their other nerve networks has led to a means to cost and often debilitating both monitor the neural signals produced side effects. by the body and decode them, not only to control inflammation, but to also anticipate incipient disease before it takes hold.

Northwell Health 15 Director Richard Barakat, MD, pictured back row center

Institute of Cancer Research – Discovering new paths that shape the delivery of cancer treatments

We research cancer and related aspects of cell biology to understand the abnormal growth and behavior of cells that have been malignantly transformed. This information is used to develop and test new diagnostics and treatments for patients suffering from several types of cancers.

We have robust areas of cancer research We have one of the largest cancer — clinical trials, basic research and programs in the New York metropolitan translational research — in order to better area and, through our residency and understand cancer, and to find new paths fellowship programs, we’re actively for shaping and delivering the best, most involved in educating the next generation effective cancer treatments. Our specialists of oncologists to provide superior clinical have expertise in research, prevention and care and develop new therapy and post-treatment care. treatment advances. Our discoveries are used to develop and Studying cancer to test new diagnostics and treatments for a variety of cancers. Because in understand the abnormal most cases of brain cancer, for example, growth and behavior treatment options are largely limited to of cells that have been surgery, radiation and chemotherapy. We malignantly transformed, are working to discover new and better and using this information treatments by designing and testing new to develop and test new drugs and drug delivery methods. diagnostics and treatments for patients suffering from various types of cancers.

16 Feinstein Institutes for Medical Research | 2018–2019 Annual Report Director Thomas McGinn, MD, MPH, pictured back row center

Institute of Health Innovations and Outcomes Research – Delivering innovative health care solutions to improve people’s health

We are a multidisciplinary team of scientists focused on developing evidence-based interventions to improve health outcomes. Our research uses mixed methodologies and the latest data analytical tools to uncover ways to improve how we deliver care and tackle health care’s most pressing issues.

We are examining how patients and Our team consists of a broad range of providers manage chronic medical clinical researchers and leverages the conditions, such as cancer, diabetes expertise of our behavioral psychologists, and heart failure, and identifying new economists, informaticists and medical approaches to lower cost, reduce disparities anthropologists. and improve quality of life. We’re changing We’re working together to develop the way physicians interact with patients multipronged interventions that engage Leveraging big data and and helping patients make personalized patients and communities to achieve the incorporating cutting-edge choices to improve their health and greatest impact on health care today. technologies to develop well-being. interventions and improve Our strength lies in our ability to collaborate health outcomes. across disciplines using innovative approaches to generate scientific evidence.

Northwell Health 17 Director Betty Diamond, MD, pictured center

Institute of Molecular Medicine – Collaborating with clinicians to better understand the treatment of disease

Our mission is to be a world leader in molecular medicine and the premier entity for the education of disease-focused molecular scientists by conducting outstanding, ground-breaking research directed at understanding molecular mechanisms of disease to promote cures and educating future generations of molecular scientists.

The Institute of Molecular Medicine is a Our collaborative approach with clinicians community of the world’s leading scientists enhances the understanding and treatment and physician-scientists conducting of disease. basic, computational, translational and clinical research. Our dedication to training future generations of molecular scientists includes Conducting outstanding, a flexible and dynamic curriculum to ground-breaking research educate post-doctoral students and junior directed at understanding faculty seeking to become successful independent investigators. molecular mechanisms of disease to promote cures and educate future generations of molecular scientists.

18 Feinstein Institutes for Medical Research | 2018–2019 Annual Report Investigators are listed below by Institute. Directors of each Institute are listed first in bold. Researchers may have appointments across Institutes, making it a collaborative environment.

Institute of Behavioral Institute of Cancer Science Research John Kane, MD Richard Barakat, MD Miklos Argyelan, MD Lionel Blanc, PhD Anita Barber, PhD Shih-Shih Chen, PhD Emily Barkley-Levenson, PhD Nicholas Chiorazzi, MD Michael Birnbaum, MD Yasmine Kieso, PhD Daniel Coletti, PhD Jeffrey Lipton, MD, PhD Barbara Cornblatt PhD, MBA Johnson Liu, MD Christoph Correll, MD Adrianna Vlachos, MD, PhD Kristina Deligiannidis, MD Xiao Jie Yan, MD, PhD Pamela Derosse, PhD Philipp Homan, MD, PhD Institute of Health Vivian Kafantaris, MD John Kane, MD Innovations and Outcomes Todd Lencz, PhD Research Anil Malhotra, MD Thomas McGinn, MD, MPH Jonathan Morgenstern, PhD Allan Abramson, MD Anthony Pinto, PhD Melissa Basile, PhD Delbert Robinson, MD Ruthee L. Bayer, MD Jose Rubio-Lorente, MD Catherine Benedict, PhD Keith Shafritz, PhD David Bernstein, MD Nehal Vadhan, PhD Lauren Block, MD, MPH Anna Van Meter, PhD Thomas Bradley, MD Jianping Zhang, MD, PhD Ronald Burakoff, DMD, MPH Jane Carleton, MD Institute of Maria T. Carney, MD Bioelectronic Medicine Kit Cheng, MD Jessica Cohen, MD Yousef Al-Abed, PhD Stuart Cohen, MD Lance Becker, MD Joseph Conigliaro, MD, MPH Stephan Bickel, MD Peter Costantino, MD Chad Bouton James Crawford, MD Eric Chang, PhD John D’Angelo, MD Sangeeta Chavan, PhD Rachel Dankner, MD, MPH Timir Datta-Chaudhuri, PhD Karina Davidson, PhD Daniel Grande, PhD Craig DeVoe, MD Jared Huston, MD John DiCapua, MD Junhwan Kim, PhD Michael Diefenbach, PhD Chunyun Li, PhD James Dolimpio, MD Ashesh Mehta, MD, PhD Laura Donahue, MD Larry Miller, MD Jonathan Dropkin, ScD, PT, CPE Raj Narayan, MD Bruce Farber, MD Valentin Pavlov, PhD Sherry Farzan, MD Michael Poon, MD Steven Fishbane, MD Loren Rieth, PhD Joanna Fishbein, MPH Kevin Tracey, MD Adiel Fleischer, MD Huan Yang, PhD Amit Garg, MD Stavros Zanos, PhD Cristina Ghiuzeli, MD Theo Zanos, PhD

Northwell Health 19 Gary L. Goldberg, MD Mariecel Pilapil, MD Anne Golden, PhD Leonid Poretsky, MD Harly Greenberg, MD Jill Maura Rabin, MD Blaine Greenwald, MD Karin Rhodes, MD Negin Hajizadeh, MD, MPH Sadia Riaz, DO Yael Tobi Harris, MD, PhD Safiya Richardson, MD, MPH Alan Hartman, MD Pina Sanelli, MD, MPH Bruce Hirsch, MD Steven Savona, MD Jamie Hirsch, MD Rebecca Schwartz, PhD Gloria Ho, PhD Julie Schwartzman-Morris, MD Mark Hoffman, MD Nagashree Seetharamu, MBBS Diane Lewis Horowitz, MD Yalini Senathirajah, PhD Tochi Iroku-Malize, MD Nicholas Sgaglione, MD Veena John, MD Amy Sharma, MD Artemio Jongco, MD, PhD Ruby Sharma, MBBS Barry Kaplan, MD Robert Silverman, MD, MS Corey Karlin-Zysman, MD, MPH Varinder Singh, MD Stanley Katz, MD Liron Sinvani, MD Elena Katzap, DO Cristina Sison, PhD Louis Kavoussi, MD Alex Spyropoulos, MD Eun Ji Kim, MD Adam Stein, MD D’Arcy King Kevin M. Sullivan, MD Myriam Kline, PhD Keith Scott Sultan, MD Nina Kohn, MBA, MA Arun Swaminath, MD Lewis Lane, MD Jamie Szeinuk, MD, MSc Martin Lesser, PhD, EMT-CC Anthony Szema, MD Anna Levy, DO Arunabh Talwar, MD Tara Liberman, DO Sewit Teckie, MD Brian Lima, MD Glenda Trujillo, PhD John N. Makaryus, MD James Tsang, MPH Prashant Malhotra, MD Ira Udell, MD Galina Marder, MD Omolara Uwemedimo, MD, MPH Lyndonna Marrast, MD, MPH Janice Wang, MD Simon Maybaum, MD Jason Wang, PhD Paul Mayo, MD Mae Ward, RN, MS, ANP, CCRN-k, CCRC Joseph McGowan, MD Lora Weiselberg, MD Andrew Menzin, MD Paul Wright, MD Larry Miller, MD Meng Zhang, PhD Jacqueline Moline, MD, MSc Xinhua Zhu, MD Christine Molmenti, PhD Jeanne Morley, MD Institute of Molecular Alyson Myers, MD Jason Naidich, MD Medicine Souhel Najjar, MD Betty Diamond, MD Sonali Narain, MD Yousef Al Abed, PhD Michael Nimaroff, MD Monowar Aziz, PhD Chris Nouryan, PhD Betsy Barnes, PhD Renee Pekmezaris, PhD Stephan Bickel, MD, PhD John S. Pellerito, MD Lionel Blanc, PhD Tony Philip, MD Ona Bloom, PhD

20 Feinstein Institutes for Medical Research | 2018–2019 Annual Report Vincent Bonagura, MD Jeffrey Nicastro, MD Ariel Brandwein, MD Mahendar Ochani, MD Max Brenner, MD, PhD Shresh Pathak, PhD Lior Brimberg, PhD Shahana Perveen, MD Thomas Chaly, PhD Jose Prince, MD Amanda (YanFan) Chan, PhD Tam Quach, PhD Wayne (Wenren) Chaung, PhD Jesse Roth, MD, FACP Shih-Shih Chen, PhD Lorry Rubin, MD Kai-Fan Cheng, PhD Rosamaria Ruggieri, PhD Nicholas Chiorazzi , MD Santiago Ruiz Perera, PhD Champa Codipilly, PhD Frances Santiago-Schwarz, PhD Gene Coppa, MD Richard Schanler, MD Cristina D’Abramo, PhD Steven Schneider, MD, FACS Anne Davidson, MD Michael Schulder, MD, FAANS Peter Davies, PhD Christine Sethna, MD Clifford Deutschman, MS, MD Archna Sharma, PhD James A. DeVoti, PhD Barbara Sherry, PhD Vijay Dhawan, PhD Andrew Shih, PhD David Eidelberg, MD Kim Simpfendorfer, PhD Douglas Frank, MD Pravin Singhal, MD Yun Freudenberg-Hua, MD Samuel Soffer, MD Sleiman Ghorayeb, PhD Myoungsun Son, PhD Luca Giliberto, MD, PhD Phoebe Spetsieris, PhD Jesus Gomar, PhD Bettie Steinberg, PhD Marc Gordon, MD Joel Stern, PhD Peter Gregersen, MD Jolien Suurmond, PhD Dorota Gruber, DHSc Marc Symons, PhD Patricio Huerta, PhD Chris Chengke Tang, MD, PhD Joyce Hui Yuen, MD Matthew Taylor, MD Mundeep Kainth, DO, MPH Sarah Rivkah Vaiselbuh, MD Yasmine Kieso, PhD Andrea Vambutas, MD Junhwan Kim, PhD Asha Varghese, PhD Sun Jung Kim, PhD Adrianna Vlachos, MD Aya Kitabayashi, PhD An Vo, PhD Jeremy Koppel, MD Bruce Volpe, MD Czeslawa Kowal, PhD Ping Wang, MD Xiqian Lan, PhD Rong Wu, MD, PhD David Langer, MD Xiao Yan, MD, PhD Annette Lee, PhD Weng Lang Yang, PhD Wentian Li, PhD Fangming Zhang, PhD Jeffrey Lipton, MD, PhD Mian Zhou, MD Johnson Liu, MD Yong-Rui Zou, PhD Yilong Ma, PhD Cynthia Aranow, MD Meggan Mackay, MD, MS Eric Chang, PhD Ashwani Malhotra, PhD Sangeeta Chavan, PhD Susan Malkiel, PhD Daniel Grande, PhD Philippe Marambaud, PhD Valentin Pavlov, PhD Bharati Matta, MS Haichao Wang, PhD Paul Mattis, PhD, ABPP-CN Christine Metz, PhD Debra Morrison, PhD

Northwell Health 21 Research directory

There are 4,000 Feinstein Institutes investigators and staff who collaborate with more than 15,000 physicians across Northwell Health. Together, they touch the lives of millions of patients each year.

The directory on the following pages includes those with Feinstein Institutes appointments – they are listed alphabetically by name.

22 Feinstein Institutes for Medical Research | 2018–2019 Annual Report ALLAN ABRAMSON, MD YOUSEF AL-ABED, PhD STEVEN ALLEN, MD CYNTHIA ARANOW, MD Professor Professor Professor Professor

Dr. Abramson’s research focus Dr. Al-Abed leads the Dr. Allen conducts clinical Dr. Aranow specializes in is on otolaryngology and Institute of Bioelectronic trials involving the treatment lupus and rheumatoid diseases of the airway. He Medicine, which aims to of patients with hematologic arthritis. She is the clinical is collaborating with others discover and develop novel malignancies like chronic director of the Feinstein on a clinical trial studying therapeutics for human lymphocytic leukemia. Institute Center for Clinical a treatment for recurrent diseases including lupus, Research in Autoimmune respiratory papillomatosis. arthritis, diabetes, Alzheimer’s Disease and co-director of disease and sepsis. This the Clinical Trials Unit. She research integrates target conducts studies to better discovery with medicinal understand and develop chemistry to generate small treatments for diseases such organic compounds and as lupus and rheumatoid potential drugs. arthritis.

MIKLOS ARGYELAN, MD MONOWAR AZIZ, PhD RICHARD BARAKAT, MD ANITA BARBER, PhD Assistant Professor Assistant Professor Professor Assistant Professor

Dr. Argyelan’s research Dr. Aziz’s research focus is on Dr. Barakat leads the Institute Dr. Barber’s research focuses projects are in schizophrenia understanding the underlying of Cancer Research. He is an on brain networks underlying and electroconvulsive mechanisms of sepsis to internationally recognized cognitive control functions therapy, and he aims to develop better therapies to surgeon and clinical and their development, develop new insights in prevent progression of organ investigator specializing in both in the neurotypical and the pathophysiology of injury and septic shock. robotic and laparoscopic clinical populations. She uses neuropsychiatric disorders. treatment of uterine cancer task and resting state fMRI and radical debulking to understand how brain procedures for ovarian cancer. networks synchronize and His research focuses on de-synchronize their activity lymphedema in women with to perform these functions. gynecologic cancer as well as identifying the best surgical methods to treat various gynecologic cancers.

Northwell Health 23 BETSY BARNES, PhD JACQUELINE C. MELISSA BASILE, PhD DAVID BATTINELLI, MD Professor BARRIENTOS, MD Instructor Professor Associate Professor

Dr. Barnes’ laboratory studies Dr. Barrientos’ research focus Dr. Basile is a medical Dr. Battinelli’s research a family of transcription is on chronic lymphocytic anthropologist in the area focuses on clinical education, factors that demonstrate leukemia (CLL) and lymphoma. of implementation and faculty development being immune regulators She is a principal investigator dissemination science. of teaching skills and and tumor suppressors. Her of numerous clinical research Her research is focused on internal medicine. lab’s specific interests are in studies from early stage processes of deliberation and blood cancers, breast cancer development to registration decision making for patients and autoimmune diseases, trials investigating new with advanced chronic including lupus. CLL therapies. lung diseases.

RUTHEE L. BAYER, MD LANCE BECKER, MD, FAHA DAVID BERNSTEIN, MD STEPHAN BICKEL, MD, PHD Assistant Investigator Professor Professor Assistant Professor

Dr. Bayer is an oncologist Dr. Becker’s research focuses Dr. Bernstein’s research Dr. Bickel’s research focuses with a focus on bone on the acute resuscitation focus is on viral hepatitis, on understanding neural marrow transplants. of dying and critically sick nonalcoholic fatty liver networks involved in epilepsy patients. A current focus of his disease, primary biliary and cognitive functions such lab at the Feinstein Institutes cholangitis, autoimmune liver as attention and memory. is on developing emergency disease, liver cancer, cirrhosis; He aims to develop new cardiopulmonary bypass outcomes in liver disease, non-invasive and invasive coupled with advanced drugs access to care and public electrical stimulation to save lives of patients who policy. His most recent work approaches modulate these fail traditional advanced is concentrated on developing networks for diagnostic and cardiovascular life support new treatments for chronic therapeutic purposes. (ACLS) treatment. hepatitis C.

24 Feinstein Institutes for Medical Research | 2018–2019 Annual Report MICHAEL BIRNBAUM, MD LIONEL BLANC, PhD LAUREN BLOCK, MD, MPH ONA BLOOM, PhD Assistant Professor Associate Professor Assistant Professor Associate Professor

Dr. Birnbaum’s research Dr. Blanc’s research focuses on Dr. Block’s research focus Dr. Bloom’s research focuses focuses primarily on developmental erythropoiesis is on trainee wellness, on identifying the molecular psychotic disorders with and its impairment in interprofessional education, factors necessary to recover an emphasis on the early pathological conditions and curriculum development. from central nervous system stages of illness and first- and why genetic disorders (CNS) injury or disease. episode schizophrenia. He in erythroid development Towards that goal, her lab has explored components trigger a cancer predisposition is investigating factors that essential for the development in children, notably influence the course of CNS of successful early osteogenic sarcoma. injury or disease, as well as intervention services, reducing the process to recover from the duration of untreated CNS injury or disease. psychosis, and improving engagement and long-term functional outcomes.

VINCENT BONAGURA, MD JOHN BOOCKVAR, MD CHAD BOUTON THOMAS BRADLEY, MD Professor Professor Professor Associate Professor

Recurrent respiratory Dr. Boockvar’s research Mr. Bouton researches Dr. Bradley is an oncologist papillomatosis (RRP) is a interests focus on malignant and develops biomedical specializing in genitourinary disease caused by the human brain tumor formation, technology with a focus in malignancies — prostate papillomavirus (HPV)—it is treatment and ways to neurotechnology and cancer, kidney cancer, the recurrence of tumors of overcome resistance to analytics. Most recently, he bladder cancer and testicular the upper airway that can therapy. In addition to his developed neural decoding cancers — and is involved in lead to airway blockages and basic science interests, he methods allowing the first conducting clinical trials of suffocation. Dr. Bonagura currently conducts multiple paralyzed person with a brain treatments associated with studies the immune response clinical trials using blood- implant to move again with these conditions. to HPV to understand why brain barrier disruption his own thoughts. RRP patients do not produce to deliver high-dose the needed immune response chemotherapy for patients to prevent or control the virus. with malignant brain tumors.

Northwell Health 25 MAX BRENNER, MD, PhD LIOR BRIMBERG, PhD DANIEL BUDMAN, MD RONALD BURAKOFF, Assistant Professor Assistant Professor Professor DMD, MPH Professor

Dr. Brenner’s research goal Dr. Brimberg’s research Dr. Budman conducts Dr. Ronald Burakoff is is to discover and develop focuses on maternal brain preclinical, translational Chairman of the Department better treatments for reactive autoantibodies in and phase I, II and III of Dental Medicine at Long patients with autoimmune autism. She discovered that clinical research in an effort Island Jewish Medical Center and inflammatory diseases. mothers of children with to determine new drug and North Shore University Recent areas of focus include autism have an increased developments for cancer. Hospital. He is the founding rheumatoid arthritis and frequency of anti-brain chair and professor of the inflammatory bowel disease. antibodies and is working to Department of Dental develop a therapeutic target Medicine at the Zucker School for autism. of Medicine at Hofstra/ Northwell. He is also the chair of the Appointments & Promotions Committee of the new medical school. His research focuses on Dental Health Service Delivery Systems.

JANE CARLETON, MD MARIA T. CARNEY, MD THOMAS CHALY, PhD AMANDA (YANFAN) CHAN, Assistant Professor Associate Professor Associate Investigator PhD Assistant Investigator

Dr. Carleton’s research focuses Dr. Carney’s Research focuses Dr. Chaly’s research focuses on Dr. Chan is manager of the on breast cancer prevention on advanced care planning, the development of Positron Light Microscopy Facility and treatment. vulnerable populations, Emission Tomography (PET) at the Feinstein Institutes, capacity assessment, shared radiopharmaceuticals, an where she trains investigators decision making, elder abuse innovative new technology for and staff to use various and palliative medicine the diagnosis of Parkinson’s imaging systems. disease, Alzheimer’s disease and tumor monitoring. He has recently received FDA approval for three radiopharmaceuticals for PET imaging.

26 Feinstein Institutes for Medical Research | 2018–2019 Annual Report ERIC CHANG, PhD WAYNE (WENREN) CHAUNG, SANGEETA CHAVAN, MD SHIH-SHIH CHEN, PhD Assistant Professor PhD Professor Assistant Professor Assistant Investigator

Dr. Chang is a neuroscientist Dr. Chaung’s research looks to The major focus of Dr. Dr. Chen’s research focuses with expertise in develop therapies to prevent Chavan’s research is in on the crosstalk between electrophysiology and septic onset and progression. bioelectronic medicine, tumor cells and tumor microscopy. His research His work is looking at several and developing knowledge microenvironment, and focuses on how neural potential drug candidates about the neuroanatomical translating findings into signals can be used to for the treatment of sepsis pathways and neural codes in the clinic. She also develops modulate physiological and and other organ injuries the vagus nerve that underlie xenograft mouse models immunological responses including hemorrhagic shock, its regulation of the immune using primary patient cells to disease and injury. acute kidney injury, ischemia- response. She also works to and employs these models for Through an understanding reperfusion injury, stroke and develop targeted therapeutics pre-clinical studies. Her work of the neurophysiology radiation injury. for the treatment has suggested potential new that mediates brain-body of long-term effects therapeutic targets in B-cell communication, he hopes of inflammatory diseases. leukemia and lymphoma. to open new avenues for bioelectronic treatments.

KAI-FAN CHENG, PhD KIT CHENG, MD NICHOLAS CHIORAZZI, MD CHAMPA CODIPILLY, PhD Instructor Instructor Professor Associate Investigator

Dr. Kai Fan Cheng’s research Dr. Cheng’s research focuses Dr. Chiorazzi studies the Dr. Codipilly’s research is interest is in synthesizing the on breast and gynecologic activation and maturation investigating transformation small organic compounds that oncology. of B-lymphocytes and uses patterns of gut microflora target pathogenic proteins this information to develop in premature infants as a and inhibit their bioactivity and test new diagnostics function of diet aimed at with the aim of strategizing and treatments for patients understanding and preventing novel therapeutic approaches suffering from chronic infantile necrotizing in inflammatory diseases. lymphocytic leukemia (CLL), a enterocolitis (NEC) — a Currently, his research B-lymphocyte cancer residing serious gastrointestinal focuses is on the synthesis of in the blood, bone marrow disease of unknown etiology peptidomimetic molecules for and lymphoid tissues. His and a major cause of drug discovery. studies have impacted CLL morbidity and mortality in patient prognosis and care. preterm infants.

Northwell Health 27 JESSICA COHEN, MD STUART COHEN, MD DANIEL COLETTI, PhD JOSEPH CONIGLIARO, Assistant Professor Assistant Professor Assistant Professor MD, MPH Professor

Dr. Cohen’s research focuses Dr. Cohen is a cardiothoracic Dr. Daniel Coletti’s research Dr. Conigliaro’s research on anticoagulation, rapid radiologist who uses clinical focuses on patient adherence focuses on the evaluation of reversal of anticoagulants effectiveness research to to medical recommendations, provider behavior change, and protocol development for transform clinical practice. He in particular, decisions brief interventions to inpatient anticoagulation. focuses on determining the people make about reduce hazardous drinking optimal diagnostic strategy taking medication. using computer interfaces, for pregnant women with health care disparities, suspicion of pulmonary and implementation of embolism. He also evaluates best practices. screening for lung disease, cardiovascular disease and malignancy in Asbestos- exposed workers and has developed an important cyclic ultra-low dose CT technique for evaluation of tracheomalacia.

GENE COPPA, MD BARBARA CORNBLATT, PhD CHRISTOPH CORRELL, MD PETER COSTANTINO, MD Professor Professor Professor Professor

Dr. Coppa’s research Dr. Cornblatt’s research Dr. Correll’s research and Dr. Constantino’s research focuses on surgery and focuses on the early clinical work focus on the focuses on the development surgical techniques. identification and treatment identification, characterization of new biomaterials and of adolescents and young and psychopharmacological surgical techniques to replace adults who are considered management of adults the facial skeleton and to be at-risk for developing and youth with severe soft tissue, enhancing the serious psychiatric illness psychiatric disorders. His ability of surgeons to restore as adults, especially areas of expertise include patients to their pre-surgical schizophrenia and other schizophrenia, bipolar appearance and function. psychotic disorders. She disorder, major depression directs the Recognition and and other psychotic, mood Prevention (RAP) program. and autism/disruptive behavior spectrum disorders.

28 Feinstein Institutes for Medical Research | 2018–2019 Annual Report JAMES CRAWFORD, MD, PhD CRISTINA D’ABRAMO, PhD JOHN D’ANGELO, MD TIMIR DATTA-CHAUDHURI, Professor Assistant Professor Assistant Professor PhD Assistant Professor

Dr. Crawford’s research Dr. D’Abramo’s research Dr. D’Angelo’s research focuses Dr. Datta’s focus is on the focuses on advancing the focuses on Alzheimer’s on identifying the signs of intersection of biology role of pathology and the disease and how to study sepsis and developing sepsis and electronics. His early clinical laboratory in the tau and amyloid precursor treatment protocols. work involved neural effective delivery of health proteins (APP) as an early networks and neuromorphic care. This includes effective biomarker of the disease and computing. Now his work utilization and interpretation to track the condition during focuses on the development of laboratory testing, the use pharmacological treatments. of implantable neural of laboratory data to manage interfaces for treatment of patient populations and diseases and for augmenting determining the efficacy of human capability. the clinical management of patients as driven by critical laboratory values.

ANNE DAVIDSON, MBBS KARINA DAVIDSON, PHD PETER DAVIES, PhD KRISTINA DELIGIANNIDIS, Professor Professor Professor MD Associate Professor

Dr. Davidson’s current Dr. Davidson focuses on The major goal of Dr. Davies’ Dr. Deligiannidis interests are focused on innovations in personalized research is to improve the research focuses on pathogenesis and therapy of trials to creatively disrupt understanding of Alzheimer’s psychoneuroendocrinology lupus. Her lab’s first goal is to the way we manage chronic disease to allow for the and neuroendocrine understand more about the diseases, conditions, discovery, development and biomarkers of depression in regulation of autoantibody- symptoms and behaviors. Her testing of effective therapies. women during peripartum producing B cells and to use previous research investigated Recent work focuses on period; gender differences in newly-discovered pathways of the etiologies, mechanisms activation of cell cycle depressions and treatment immune activation to design and interventions of mechanisms in Alzheimer’s response; and complementary and test novel therapies psychological and behavioral disease and modifications of and alternative/integrative for lupus. factors thought to the microtubule-associated treatments. influence hypertension and protein tau as a reporter for cardiovascular disease. signal transduction in the human brain.

Northwell Health 29 PAMELA DEROSSE, PhD CLIFFORD DEUTSCHMAN, CRAIG DEVOE, MD VIJAY DHAWAN, PhD Assistant Professor MD Assistant Professor Professor Professor

Dr. DeRosse’s research focuses Dr. Deutschman’s research Dr. DeVoe’s research focuses Dr. Dhawan’s research on the biological, behavioral focuses on sepsis. He has on identifying and testing focuses on how biophysics and environmental factors recently become involved in innovative treatments and bioengineering can be that contribute to the some aspects of epidemiology, for cancer including applied to neuroscience, development of psychotic care delivery and health immunotherapies. and particularly to the study disorders. She is particularly service responses in patients of disease mechanisms in interested in understanding with sepsis. movement disorders and how these risk factors might other neurodegenerative inform treatment approaches conditions. to improve short- and long- term outcomes in those suffering from these disorders.

BETTY DIAMOND, MD JOHN DICAPUA, MD MICHAEL DIEFENBACH, PhD DAVID EIDELBERG, MD Professor Associate Professor Professor Professor

Dr. Diamond leads the Dr. DiCapua’s research focuses Dr. Diefenbach’s research Dr. Eidelberg directs an Institute of Molecular on pain management issues focuses on the cognitive imaging research program in Medicine. She studies the and perioperative operational and affective factors as they brain disease. His program induction and pathogenicity management and clinical relate to health behaviors has developed novel imaging of DNA-reactive antibodies staffing models. and decision making. He techniques to characterize in lupus. These studies is translating these basic and quantify neural circuits in are designed to provide findings into patient-centered neurodegenerative disorders new strategies to prevent interventions, with the goal of and to study their modulation autoimmunity or protect improving patient adjustment by using functional imaging against tissue damage in to disease and treatment and with PET and fMRI. This lupus. She also studies the quality of life. approach has provided unique contribution of maternal insights into Parkinson’s antibody to abnormal disease and related brain development. movement disorders.

30 Feinstein Institutes for Medical Research | 2018–2019 Annual Report DEBORAH ELKIS-ABUHOFF, BRUCE FARBER, MD SHERRY FARZAN, MD STEVEN FISHBANE, MD PhD Professor Assistant Professor Professor Assistant Professor

Dr. Elkis-Abuhoff’s research Dr. Farber’s research Dr. Farzan’s research focuses Dr. Fishbane’s research interests bring together focuses on the treatment on asthma and obesity. focuses on hyperkalemia behavioral medicine and and prevention of Asthma is a chronic condition management, complications creative/medical art therapy infectious diseases. that affects children and of kidney disease, with neuroscience. Her recent adults. The severity and inflammation in kidney research projects connect art control of asthma is adversely disease, quality management therapy with those diagnosed affected by obesity, and in kidney disease anemia with Parkinson’s disease, asthma medications do and iron management and cancer and connecting not work as well in obese outcomes of kidney disease. the creative process to patients. Dr. Farzan studies neurological responses. the underlying reasons for the adverse effects of obesity on asthma.

JOANNA FISHBEIN, MPH ADIEL FLEISCHER, MD GIOVANNI FRANCHIN, PhD DOUGLAS FRANK, MD Assistant Investigator Professor Assistant Professor Associate Investigator

Ms. Fishbein is a Dr. Fleischer specializes in Dr. Franchin’s recent focus Dr. Frank’s research interests biostatistician with a research maternal/fetal medicine and is on clinical research and include investigations into focus on identifying and obstetrics and gynecology. He patient care. He is interested the pathogenesis of HPV evaluating a set of short-term oversees clinical operations in lupus and rheumatoid associated oropharynx cancer renal measurements that for both obstetrics and arthritis, and is involved in collaboration with Feinstein predict long-term responses gynecology and is involved in with clinical trials looking Institutes investigators for use in future lupus the development of women’s at new therapeutic targets Drs. Bettie Steinberg and nephritis clinical trials. health services. for these diseases. He is also Vincent Bonagura. investigating the link between metabolism and disease activity in patients with lupus.

Northwell Health 31 YUN FREUDENBERG-HUA, RICHARD A. FURIE, MD AMIT GARG, MD SLEIMAN GHORAYEB, PhD MD Professor Professor Investigator Assistant Professor

Dr. Freudenberg-Hua’s The goal of Dr. Furie’s Dr. Garg’s research focuses Dr. Ghorayeb’s research research focuses on research is to investigate on developing instruments includes diagnostic and psychiatry and geriatric the signaling pathways in and assessing clinical and therapeutic ultrasound in psychiatry. myeloproliferative diseases patient-centered outcomes orthopaedics, dentistry, — a group of conditions that in psoriasis. He has also ophthalmology, urology and cause blood cells to grow developed innovative teaching obstetrics and gynecology. abnormally in the bone strategies to improve training Projects include assessment marrow, over the course of and education outcomes. of osteoporosis; dental the disease. Understanding Dr. Garg’s recent research pulp stem cells; penile, these mechanisms could has focused on improving testicular and cervical tissue allow for the development of teaching and assessment characterization; retinal more efficacious and better- methods in undergraduate reattachment; and evaluation targeted therapies. and graduate medical of cartilage implanted with education. preconditioned scaffolds.

LUCA GILIBERTO, PhD ANNE GOLDEN, PHD TODD GOLDSTEIN, PhD JESUS GOMAR, PHD Assistant Professor Associate Investigator Instructor Assistant Professor

Dr. Giliberto’s work focuses Dr. Golden is an Dr. Goldstein’s research Dr. Gomar’s research on the hypothesis that epidemiologist whose focuses on utilizing 3D focuses on multimodal alterations of cell cycle research focuses on the technologies for tissue neuroimaging techniques signaling can disrupt neuronal carcinogenic effects engineering and patient to study neurodegeneration networks, with accumulation of occupational and specific treatments. Most in Alzheimer’s disease. of amyloid and tau, leading environmental exposures, and recently, his team has These techniques include to neurodegeneration. Other the development of methods developed and 3D-printed magnetic resonance imaging interests are the function applicable to studying these living lab grown tracheas. and molecular imaging to of tau as a fundamental issues. Current projects Additionally he has developed measure amyloid and tau neuroplasticity molecule, and include an Occupational Lung amphibious prosthetic legs for proteinopathies as well as the effects of brain trauma on Disease Registry of asbestos- both civilians and wounded neuroinflammation. He also the accumulation of tau and exposed workers and a warriors. investigates potential risk neurodegeneration. cohort study of cancer among factors that contribute to the firefighters in New York. development of Alzheimer’s disease in healthy aging.

32 Feinstein Institutes for Medical Research | 2018–2019 Annual Report MARC GORDON, MD DANIEL A. GRANDE, PhD HARLY GREENBERG, MD BLAINE GREENWALD, MD Professor Professor Professor Associate Professor

Dr. Gordon’s research focuses Dr. Grande’s research aims Dr. Greenberg’s research Dr. Greenwald’s research on behavioral neurology and to improve treatments efforts are in the field of sleep focuses on geriatric neuropsychiatry. He leads for injuries of the medicine. Recent work has mental health. clinical research studies in musculoskeletal focused on the cardiovascular Alzheimer’s disease, mild system, including cartilage pathophysiology of sleep cognitive impairment and regeneration and repair, apnea and intermittent vascular dementia. His current meniscus repair, tendon hypoxia, assessing functional research involves clinical repair and bone fracture outcomes of sleep apnea trials of novel medications, augmentation and fusion. therapy and on biomarker studies and Recent focus has been developing novel diagnostic imaging techniques. on developing novel cell- and screening modalities for modified scaffolds for sleep-disordered breathing. enhancing tendon repair and methods to provide gene therapy and tissue- engineered constructs for bone injuries.

PETER GREGERSEN, MD DOROTA GRUBER, DHSC NEGIN HAJIZADEH MD, PhD YAEL TOBI HARRIS, MD, PhD Professor Assistant Investigator Assistant Professor Assistant Professor

Dr. Gregersen conducts Dr. Gruber is investigating Dr. Hajizadeh’s research Dr. Harris’ research focuses on international collaboration the genetic basis of focuses on improving end- diabetes mellitus, medication efforts to achieve a congenital heart disease. of-life care in patients with adherence in patients comprehensive genetic Her research objective is advanced chronic disease, by with diabetes, obesity and description for autoimmune to integrate careful clinical informing decision making endocrine complications of diseases, with a particular characterization of patients with prognostic data and iron overload. focus on lupus and and families with cutting- effective doctor-patient rheumatoid arthritis. He edge genetic analyses in communication in advance of also studies a number of order to gain insight into critical illness. newly-defined risk genes for the molecular mechanisms autoimmunity, several of underlying heart disease which are potential targets of and discover new genetic new drugs. syndromes.

Northwell Health 33 ALAN HARTMAN, MD BRUCE HIRSCH, MD JAMIE HIRSCH, MD GLORIA HO, PhD Associate Professor Assistant Investigator Assistant Professor Professor

Dr. Hartman’s research Dr. Hirsch’s research focus Dr. Hirsch’s research focuses Dr. Ho’s research examines focuses on aortic aneurysm, is on the role of the gut on leveraging large-scale the potential of circulating pulmonary embolectomy, microbiome in health electronic health record data microRNA and circulating valve repair, minimally and disease. to improve the quality of tumor DNA as early detection invasive surgery, coronary care delivery on individual and prognostic biomarkers bypass surgery and and population health for cancers. mechanical assist devices. levels. His work examines disparate data sources and types and uses machine learning and artificial intelligence methodologies to create predictive models of disease progression and risk stratification.

MARK HOFFMAN, MD PHILIPP HOMAN, MD, PhD DIANE LEWIS HOROWITZ, PATRICIO T. HUERTA, PhD Associate Professor Assistant Professor MD Professor Assistant Professor

Dr. Hoffman’s interests Dr. Homan uses Dr. Lewis Horowitz’s research Dr. Huerta is interested in include breast cancer, computational methods focuses on rheumatology, exploring the interactions gynecologic malignancies, and brain imaging to study studying novel therapeutics between the nervous system benign hematology, individual differences in for rheumatoid arthritis, and the immune system hematological malignancies treatment response in medical decision-making, in health and disease. He and supportive care. He schizophrenia. rheumatoid arthritis currently studies brain is especially focused on therapeutic use, shared abnormalities occurring in communication skills training decision-making and bone lupus and sepsis-induced for oncology fellows. health in rheumatoid arthritis. long-term cognitive deficit, with the goal to isolate key immune and neural mechanisms with the purpose of creating therapies for autoimmunity and brain disorders.

34 Feinstein Institutes for Medical Research | 2018–2019 Annual Report JARED HUSTON, MD TOCHI IROKU-MALIZE, MD, VEENA JOHN, MD ARTEMIO JONGCO III, Assistant Professor Professor Assistant Investigator MD, PhD Assistant Professor

Dr. Huston’s research focuses Dr. Iroku-Malize’s research Dr. John’s research focuses Dr. Jongco’s research focuses on the understanding of how focuses on clinical on gynecologic malignancies, on expanding newborn the central nervous system medicine, public health, working with new drugs to screening to include primary maintains homeostasis and health care systems and find better treatment options immunodeficiencies, which protects against traumatic academic medicine. in ovarian cancer, endometrial includes close collaboration injury. He is currently studying cancer and cervical cancer. She with the NYS Department of the beneficial effects of vagus is involved with phase I, II, and Health’s newborn screening nerve stimulation with the III studies. She is the principal program to develop and hope that it can improve care investigator to all gynecologic optimize multiplex assays to of traumatized patients. oncology group studies and detect infants with T and/or many pharmaceutical studies. B cell lymphopenia shortly She is also involved with after birth using existing investigator-initiated trials in infrastructure. gynecology.

VIVIAN KAFANTARIS, MD MUNDEEP KAINTH, JOHN KANE, MD BARRY KAPLAN, MD Assistant Professor DO, MPH Professor Assistant Professor Instructor

Dr. Kafantaris’ main Dr. Kainth’s research focuses Dr. Kane leads the Institute of Dr. Kaplan’s research focuses research focuses on the on influenza vaccine immune Behavioral Science. His focus on specialized inpatient care pharmacological treatment responses in children and is in the field of schizophrenia for cardiovascular patients. of bipolar disorder and the modifying factors of research. His work has the related area of severe obesity and metabolic focused on improving the dysregulated aggression health. Her previous research early diagnosis and treatment associated with conduct includes investigation of the of schizophrenia, as well as disorder or oppositional relationship between HIV developing new treatments defiant disorder. She and human herpes virus 6 and treatment strategies currently studies the infections. to enhance patient long- neurodevelopmental term effectiveness and underpinnings of bipolar quality of life. disorder and treatment with lithium.

Northwell Health 35 COREY KARLIN- STANLEY KATZ, MD ELENA KATZAP, DO LOUIS KAVOUSSI, MD ZYSMAN MD, MPH Professor Assistant Investigator Professor Assistant Investigator

Dr. Karlin-Zysman research Dr. Katz’s research focuses Dr. Katzap is an attending Dr. Kavoussi is dedicated to focuses on hospital medicine on intervention and acute physician with the Division of the treatment of urological co-management, medicine in myocardial infarction. Rheumatology and is involved disease through innovative inpatient psychiatry and unit- in many clinical trials relating surgical procedures, based care models. to osteoarthritis as well as diagnostics and medical care. other autoimmune diseases.

YASMINE KIESO, PHD JUNHWAN KIM, PhD SUN JUNG KIM, PhD D’ARCY KING, PhD Assistant Investigator Assistant Professor Assistant Professor Assistant Investigator

Yasmine Kieso’s research Dr. Kim’s research background Dr. Kim’s research focus is Dr. King’s research focuses focuses on chronic is in synthetic chemistry, to identify the regulatory on developing solutions lymphocytic leukemia (CLL). analytical biochemistry and mechanism of inflammatory geared towards addressing She is intimately involved mitochondrial physiology. His function of dendritic cells and the changing patient-centric in translational clinical research interests are focused to understand the molecular business needs of pharma research relating to a benign on understanding the role mechanisms underlying and health care organizations. CLL precursor, monoclonal that mitochondria and lipids inhibition of development b-cell lymphocytosis (MBL), play for ischemia/ reperfusion of autoimmune diseases, to define biomarkers as injury in cardiac arrest and the particularly in lupus and targets to prevent or delay the translation of these findings inflammatory bowel diseases. progression to CLL. into clinical practice.

36 Feinstein Institutes for Medical Research | 2018–2019 Annual Report MYRIAM KLINE, PhD NINA KOHN, MBA, MA JONATHAN KOLITZ, MD JEREMY KOPPEL, MD Assistant Investigator Associate Investigator Professor Associate Professor

Dr. Kline is a biostatistician Nina Kohn is a biostatistician Dr.Kolitz is an oncologist Dr. Koppel is a basic science with a focus on with a focus on analysis with a specialty in and clinical researcher psychometrics, multivariate of longitudinal data, hematologic malignancies at focusing on the neurobiology modeling, survival analysis, including missing data or Northwell Health’s Monter of psychosis in Alzheimer’s and nonparametric methods. data collected at irregular Cancer Center. disease, and the impact of intervals, non-parametric and antipsychotic medications on exact methods, statistical disease pathology. graphics, and the design of clinical trials.

CZESLAWA KOWAL, PhD XIQIAN LAN, PhD LEWIS LANE, MD DAVID J. LANGER, MD Associate Professor Assistant Professor Professor Associate Professor

Dr. Kowal’s research focuses Dr. Lan’s research focuses Dr. Lane is an orthopaedic Dr. Langer has focused his on the mechanisms of the on the effect of the APOL1 surgeon with a specialty clinical attention to diseases antibody-mediated neuronal gene on the health of in surgery of the hand and of the brain vessels, including abnormalities leading to brain African Americans. focuses his research on cerebral revascularization and pathology and to hormonal tendon healing. cerebral aneurysms. serum alterations in lupus. Projects include the function of the blood-brain barrier in the antibody-mediated pathology of the adult brain and of the maternal antibody- mediated abnormalities in the developing brain.

Northwell Health 37 ANNETTE LEE, PhD TODD LENCZ, PhD MARTIN LESSER, PhD, EMT-CC CHUNYAN LI, PhD Associate Professor Associate Professor Professor Assistant Professor

Dr. Lee’s current research Dr. Lencz researches the use of Dr. Lesser is a biostatistician Dr. Li’s research focuses on focus is to discover and biomarkers, especially novel and assists investigators monitoring and treating validate new biomarkers for genetic technologies, to better in data analysis, research the injured brain. Projects early detection, prediction of understand the causes and question formulation, study include developing the disease course and outcome treatment of schizophrenia. design, data management, next generation brain and treatment response in He develops and implements storage and retrieval, as well multimodality monitoring cancer, particularly breast and strategies for identifying as publication preparation devices using BioMEMS ovarian cancers. relationships between genetic and patient safety and data technology, and investigating variation and psychiatric quality monitoring. trigeminal nerve stimulation disease, and examines the as a novel therapeutic role that schizophrenia risk approach to traumatic brain genes play in brain structure, injury by the activation of function and development. endogenous neuroprotective mechanisms.

WENTIAN LI, PHD HAIXIANG LIANG, MD TARA LIBERMAN, DO BRIAN LIMA, MD Investigator Assistant Investigator Assistant Investigator Professor

Dr. Li is a bioinformatician Dr. Liang’s research focuses Dr. Liberman’s research Dr. Lima’s research focuses with a focus on assessing, on tissue engineering focuses on goals of care in the on clinical outcomes in analyzing and annotating studies for the repair of the advanced illness population. the surgical treatment of biomedical data to musculoskeletal system. Her current endeavors advanced heart failure, aid biologists in their include hospice evaluation including heart transplant study, and to generate in emergency medical rooms and mechanical circulatory theoretical hypothesis on and transitions of care, as well support. He also is interested biological phenomena and as the integration of geriatric in the molecular biology human disease. trained social workers into the of heart failure, based on emergency room setting to assessment of tissue samples improve available resources in the heart biobank. for the treatment of older adults.

38 Feinstein Institutes for Medical Research | 2018–2019 Annual Report JEFFREY LIPTON, MD, PhD JOHNSON LIU, MD YILONG MA, PhD MEGGAN MACKAY, MD, MS Professor Associate Professor Associate Professor Professor

The goal of Dr. Lipton’s Dr. Liu’s research career has Dr. Ma’s research focuses Dr. Mackay is a research is the elucidation focused on the molecular on the development, rheumatologist whose of the genetics and basis of hematopoietic implementation and primary interests are in pathophysiology of Diamond- stem cell disorders, validation of innovative lupus, rheumatoid arthritis, Blackfan anemia (DBA), a collectively referred to as solutions in multimodality scleroderma and vasculitis. disorder of the bone marrow. the inherited bone marrow brain imaging applications She is a co-director of He is working with numerous failure syndromes. His with PET and MRI to study the Clinical Trials Unit collaborators to develop current research is aimed different neurodegenerative and conducts studies to genotype-phenotype at understanding the and neuropsychiatric better understand and correlations, resulting in the molecular pathophysiology disorders such as develop treatments for discovery of a number of of Diamond-Blackfan anemia Parkinson’s disease and autoimmune disease. DBA genotypes. and Shwachman-Diamond Huntington’s disease. syndrome. His lab also researches erythropoiesis and sickle cell anemia.

JOHN N. MAKARYUS, MD ANIL MALHOTRA, MD PRASHANT MALHOTRA, MD PHILIPPE MARAMBAUD, PhD Assistant Investigator Professor Assistant Professor Professor

Dr. Makaryus focuses his Dr. Malhorta works Dr. Malhotra’s research Dr. Marambaud’s research research on optimizing the on identifying the focuses on respiratory viral focuses on the molecular application and integration biological underpinning infections and the impact basis of neuronal of cardiac imaging into the of schizophrenia and of respiratory panel on degeneration in Alzheimer’s diagnosis and therapeutic determining how antibiotic use and length of disease and other dementias. management of patients antipsychotic drugs work to stay, analysis of pleural fluid His laboratory studies the with cardiovascular disease. quell the symptoms of the by genome sequencing in early biochemical changes His research also seeks to disease. His group assesses empyema, clinical prediction leading to the formation of enhance the use of multi- genes and neural circuits rules for pulmonary two classic lesions of the modality cardiovascular associated with increased tuberculosis and early Alzheimer’s disease brain: imaging to guide complex risk of schizophrenia with markers for sepsis in patients the senile plaques and the interventional, structural and the goal of developing more with intracranial hemorrhage. neurofibrillary tangles. electrophysiologic procedures. effective treatments.

Northwell Health 39 GALINA MARDER, MD LYNDONNA MARRAST, BHARATI MATTA, MS PAUL MATTIS, PhD, Assistant Professor MD, MPH Assistant Investigator ABPP-CN Assistant Professor Assistant Investigator

Dr. Mader’s research Dr. Marrast’s research Dr. Matta’s research focuses Dr. Mattis’ research focus focuses on rheumatology, interests include physician on understanding the role examines the relationship inflammatory muscle disease, workforce diversity, improving of IRF5 in the development, between cognition and vasculitis and systemic lupus access to care for underserved differentiation and effector brain functioning. erythematosus. populations and improving function of B cells, especially the delivery of primary antibody-secreting B cells. care to racial and ethnic minorities with diabetes. She plans to use technology- based interventions to reduce disparities.

THOMAS MCGINN, MD, MPH JOSEPH MCGOWAN, MD ASHESH MEHTA, MD, PhD CHRISTINE METZ, PhD Professor Professor Associate Professor Professor

Dr. McGinn leads the Institute Dr. McGowan’s research Dr. Mehta’s lab uses multiple Dr. Metz’s research focuses of Health Innovations and focuses on HIV and AIDS with methods for measuring brain on inflammation in both Outcomes Research. He a particular focus on HIV drug structure and function to pregnant and non-pregnant has taught, researched resistance, management of advance understanding of populations and identifying and worked in the area of HIV in pregnancy, anal cancer human brain function and ways to reduce and prevent academic general internal screening in HIV and the role the treatment of epilepsy. dysfunctional inflammation. medicine with a focus on of alteration in the microbiota The lab works to improve the Much of her work centers providing high-quality health in HIV immune reconstitution. diagnosis of epilepsy patients, on endothelial cells, which care in urban communities. and better understand the facilitate the rapid transport Recent areas of focus include root causes of epilepsy, and of blood and immune the validation of clinical the physiological basis of cells throughout the body, prediction rules, as well as the brain structure, function particularly to sites of prevalence, risk factors and and cognition. infection and inflammation. treatment of hepatitis C.

40 Feinstein Institutes for Medical Research | 2018–2019 Annual Report LARRY MILLER, MD JACQUELINE MOLINE, MD CHRISTINE MOLMENTI, PHD ALYSON MYERS, MD Professor Professor Assistant Professor Assistant Professor

Dr. Miller’s research focuses Dr. Moline develops initiatives Dr. Molmenti is a cancer Dr. Meyer’s research focuses on gastrointestinal physiology aimed at promoting and epidemiologist and clinical on diabetes and depression, with a focus on sphincter engaging health and wellness, researcher focused on the and understanding the mechanisms in the GI tract. and she oversees a population primary and secondary pathophysiology of these health and epidemiology prevention of colorectal two diseases and how research program. Her cancer through screening/ they interact. She also research interests include early detection and lifestyle. examines metabolic World Trade Center health Her specific research interests syndrome in patients effects, asbestos exposure, include early onset colorectal treated with antipsychotic occupational lung disorders cancer, its prevention, medications; the effects of and heavy metal toxicity. detection, screening methods, various medications on the and familial communication metabolic profile of patients of risk guidelines among first- treated with antipsychotic degree relatives. medications and the use of telehealth in persons with diabetes.

JASON NAIDICH, MD, MBA SOUHEL NAJJAR, MD RAJ NARAYAN, MD MICHAEL NIMAROFF, MD Associate Professor Professor Professor Assistant Professor

Dr. Naidich’s research Dr. Najjar’s research Dr. Narayan’s research aims to Dr. Nimaroff is a gynecologist focuses on health care policy, focuses on epilepsy, develop the next generation whose research focuses quality, and noninvasive neuroinflammation-related of human monitoring devices, on developing non- vascular imaging. neuropsychiatric disorders with a particular focus on invasive methods for and autoimmune disorders of the monitoring of the injured gynecologic surgery. central nervous system. brain. His recent work has focused on the development of a “smart catheter” for the monitoring of multiple physiological parameters simultaneously with a single monitor.

Northwell Health 41 CHRIS NOURYAN, PhD LARS PEDER S. SHRESH PATHAK, PhD VALENTIN PAVLOV, PhD Assistant Professor OLOFSSON, MD, PhD Assistant Professor Professor Professor

Dr. Nouryan’s research focuses Dr. Olofsson studies Dr. Pathak’s research focuses Dr. Pavlov’s research focuses on developing telemedicine biomedical science and on the molecular mechanisms on the regulation of immune for congestive heart failure how nerve reflexes regulate of pro-inflammatory function and inflammation patients, chart reviews of the body’s defense to cytokines in peripheral blood by the nervous system. He all shapes and sizes, surveys microorganisms and injury. immune cells from patients studies the role of brain and on a variety of topics, and a with immune-mediated peripheral neuronal pathways breast cancer project which hearing loss. in controlling cytokine randomly assigns participants responses and inflammation, to see a geriatrician or receive and the therapeutic efficacy of usual care and follows cholinergic modalities in their progress through the inflammatory and continuum of care. obesity-driven disorders and cancer-associated immune dysfunction.

RENEE PEKMEZARIS, PhD JOHN S. PELLERITO, MD SHAHANA PERVEEN, MD TONY PHILIP, MD Professor Investigator Assistant Investigator Assistant Investigator

With an emphasis on the Dr. Pellerito specializes in Dr. Perveen’s research focuses Dr. Philip’s research focuses growing population of seniors, diagnostic radiology and on pulmonary angiogenesis on the personalized care of Dr. Pekmezaris conducts has dedicated his practice and lung growth after gastrointestinal cancers and community-based research to taking care of patients hyperoxia and hypoxic injury. sarcoma (cancers of the soft investigations with seniors, with a wide range of medical She is currently working on tissue and bone) after surgery including telehealth trials for conditions including the new therapeutic modality to to reduce risk of recurrence, patients living with congestive chest, abdomen, pelvis be used in prenatal period and the prevention of heart failure. and extremities. His to improve angiogenesis these diseases. research interests include and fetal lung growth in evaluations of obstetric and association with congenital gynecologic conditions and diaphragmatic hernia to vascular diseases. improve postnatal morbidity and mortality in newborns.

42 Feinstein Institutes for Medical Research | 2018–2019 Annual Report MARIECEL PILAPIL MD, MPH ANTHONY PINTO, PhD LEONID PORETSKY, MD LOUIS POTTERS, MD, FACR, Assistant Investigator Associate Professor Professor FASTRO Professor

Dr. Pilapil’s research focuses Dr. Pinto conducts clinical Dr. Poretsky’s research focuses Dr. Potters conducts on young adults with special research in obsessive on clinical studies in diabetes research on prostate cancer, health care needs, particularly compulsive disorder (OCD) and endocrinological aspects with a focus on prostate those with conditions and obsessive compulsive of HIV infection. His current brachytherapy techniques and originating in childhood. Her personality disorder (OCPD) research interests include outcomes. He also works on research focus is aimed at and has an interest in the effects of a recently systems and process research identifying opportunities to maladaptive traits such as discovered hormone, irisin, for high-quality and safe improve care of this patient perfectionism and rigidity. in the reproductive system, treatment of innovative care population (including the the potential role of vitamin and delivery models. importance of preventative D in preventing type 2 care) and to increase diabetes; and developing provider comfort in caring for clinical strategies to reduce these patients. readmission rates in patients with diabetes.

JOSE PRINCE, MD TAM QUACH, PhD JILL MAURA RABIN, MD KANTI RAI, MD Associate Investigator Instructor Associate Professor Professor

Dr. Price’s research focuses on Dr. Quach’s research focuses Dr. Rabin’s research Dr. Rai collaborates in exploring the fundamental on human B cell biology ranges from basic science basic and clinical research mechanisms involved in the and autoimmunity, and work (estrogen receptor to conduct a number of immune response to trauma understanding mechanisms heterogeneity) to clinical experimental drug trials and organ injury. that balance the pathogenic (ambulatory care, for patients suffering from versus protective functions urogynecology) and medical chronic lymphocytic leukemia of different immune device development (seven (CLL), a cancer that resides in cells to develop new patents, one copyright). the blood, bone marrow and immunotherapies to chronic She is currently focusing on lymphoid tissues. His studies inflammation, degenerative methods to improve quality have impacted CLL patient diseases and cancer. and patient safety and in the prognosis and care. “voltage change” that occurs from the hospital to the outpatient setting.

Northwell Health 43 KARIN RHODES, MD SAFIYA RICHARDSON MD, LOREN RIETH, PhD DELBERT ROBINSON, MD Professor MPH Associate Professor Associate Professor Assistant Professor

Dr. Rhodes’ research focuses Dr. Richardson’s primary Dr. Rieth’s primary research Dr. Robinson and his first- on developing effective research interest is in the use focuses on highly effective episode schizophrenia patient-centered responses to of information technology bi-directional neural research network, which health-related social problems to integrate evidence-based interfaces to the central, includes sites across the impacting individual and medicine into daily clinical peripheral, and autonomic U.S. and in Canada, study public health. Specifically, she practice. Her current work has nervous systems. This pharmacotherapy for has addressed policy-relevant focused on usability testing, research is from basic science schizophrenia. The network questions around improving implementing, monitoring through device translation, is currently conducting the value of an acute health and evaluating clinical and focuses on the interface the RAISE trial, which care visit and use of patient- decision support. of microfabrication, assesses psychosocial and centered health IT as an materials science, biophysics, pharmacological treatments opportunity for screening, neurophysiology and for schizophrenia. brief intervention and referral. medical device design and architecture.

JESSE ROTH, MD LORRY GLEN RUBIN, MD JOSE RUBIO-LORENTE, MD ROSAMARIA RUGGIERI, PhD Professor Professor Assistant Investigator Associate Professor

Dr. Roth’s research focuses on Dr. Rubin’s current research Dr. Rubio conducts research Dr. Ruggieri’s research obesity and diabetes. Projects focuses on the epidemiology on psychotic disorders. focuses on glioblastoma include devising earlier and prevention of hospital- His focus is on treatment- and medulloblastoma, the ways to diagnose and treat acquired (nosocomial) resistant schizophrenia. most common types of brain diabetes, understanding how infection in pediatric patients. Most recently, he is studying tumors in adults and children. excess body weight brings out Most recently he has shown the clinical implications She is working on the diabetes, and uncovering how that enhanced isolation of breaking through development of an inhibitor the microbiome, the microbes precautions of inpatients antipsychotic maintenance that could provide novel in the intestine of the host, with viral respiratory infection treatment, and the treatments for these types influence the host’s food reduces nosocomial viral neurobiological correlates of tumors. intake and body weight. respiratory tract infections. of psychosis in treatment resistant patients.

44 Feinstein Institutes for Medical Research | 2018–2019 Annual Report PINA SANELLI, MD, MPH FRANCES SANTIAGO-SCHWARZ, STEVEN SAVONA, MD RICHARD SCHANLER, MD Professor PhD Assistant Investigator Professor Professor

Dr. Sanelli’s research interests Dr. Santiago-Schwarz’s Dr. Savona’s research focuses Dr. Schanler researches are focused in the technology research is concerned with on issues related to cancer neonatal nutrition and critical assessment and outcomes- the control of monocyte and including tobacco dependency inflammatory disorders of based research of brain dendritic cell development and smoking cessation, newborns. His nutritional perfusion and permeability in normal and abnormal redeveloping lifestyles and and anti-inflammatory imaging in patients with physiology as well as physical activity levels after studies aim to provide better cerebrovascular diseases, developing new therapeutic completion of chemotherapy, outcomes for infants in the particularly aneurysmal agents for autoimmune the prevention of infections neonatal intensive care unit. subarachnoid hemorrhage diseases. Current work in patients with impaired and acute stroke. Dr. Sanelli focuses on disrupted cytokine immunity and prevention has developed a research and immunoreceptor of hot flashes in patients on program focused on clinical networks affecting monocyte/ hormonal therapy. effectiveness and outcomes dendritic cell activity, research for demonstrating particularly in rheumatoid the value of imaging in health arthritis and lupus. care at Northwell Health.

CHARLES SCHLEIEN, MD, MICHAEL SCHULDER, MD, REBECCA SCHWARTZ, PhD JULIE SCHWARTZMAN- MBA FAANS Associate Professor MORRIS, MD Professor Professor Associate Professor

Dr. Schleien researches Dr. Schulder investigates Dr. Schwartz’s research Dr. Schwartzman- cardiopulmonary new methods of image focuses the role of mental Morris’ research focuses resuscitation, including guidance for neurosurgery, health and abuse on HIV- on rheumatology, brain-blood flow, drug effects, including the incorporation related outcomes and STI/ psoriatic arthritis and, metabolism and mechanics of functional MRI as well as HIV-risk, how natural disasters spondyloarthropathy and of CPR. Recently, his focus intraoperative MRI. and other types of trauma rheumatoid arthritis. has been in pediatric CPR impact mental health and and hypothermia following impact of lung cancer surgery cardiac arrest in children. on quality of life (QoL).

Northwell Health 45 NAGASHREE SEETHARAMU, CHRISTINE SETHNA, MD NICHOLAS SGAGLIONE, MD KEITH SHAFRITZ, PhD MBBS Associate Professor Professor Professor Assistant Investigator

Dr. Seetharamu’s research Dr. Sethna’s clinical and Dr. Sgaglione’s research Dr. Shafritz’s research focuses on predictive and research interests focus focuses on arthroscopy, examines the neural and prognostic biomarkers in on hypertension and minimally invasive surgery cognitive mechanisms of lung and head/neck cancers, cardiovascular outcomes and knee, shoulder and attention, executive function immuno-oncology, and in kidney disease, cartilage surgery. and emotion. He also studies precision medicine. specifically in children with psychological disorders nephrotic syndrome and that involve dysregulation kidney transplants. of these processes, such as autism and attention deficit hyperactivity disorder. He works to determine the brain mechanisms underlying behavioral disorders so that future treatments can target those specific brain areas.

ARCHNA SHARMA, PhD RUBY SHARMA, MBBS BARBARA SHERRY, PhD ROBERT SILVERMAN, MD, MS Assistant Professor Assistant Investigator Professor Associate Professor

Dr. Sharma’s research focuses Dr. Sharma’s research Dr. Sherry’s research interest Dr. Silverman researches on understanding the focuses on the prevention of is in the mechanisms that pre-diabetes and diabetes in molecular mechanisms and breast cancer, prevention of coordinate the innate emergency room patients, roles of various immune cells recurrence after surgery, and immune response. Her as well as the effects of air and inflammatory mediators treatment of recurrences. ultimate goal is to gain a pollution on asthma-related in inflammation, infection better understanding of the hospital admissions. He also and injury with a focus on molecular mechanisms that studies air pollution and sepsis and an aim to develop regulate chemokine and cardiac deaths that occur new therapeutic approaches. chemokine receptor responses outside of the hospital. in healthy individuals, and to identify how these pathways are dysregulated in sepsis, HIV infection and chronic lymphocytic leukemia.

46 Feinstein Institutes for Medical Research | 2018–2019 Annual Report KIM R. SIMPFENDORFER, PhD VARINDER SINGH, MD PRAVIN SINGHAL, MD LIRON SINVANI, MD Assistant Professor Assistant Professor Professor Assistant Professor

Dr. Simpfendorfer’s research Dr. Singh’s work is focused Dr. Singhal’s research focuses Dr. Sinani’s research focuses focuses on the functional on the quality and delivery of on studying the mechanism on geriatrics and aging analysis of immune-related cardiovascular care. of the progression of renal research, improving quality genes associated with lupus lesions in patients with of care of hospitalized older and rheumatoid arthritis. HIV-associated nephropathy adults, the management of (HIVAN), a complication of dementia and delirium in the AIDS. He also studies the hospital setting and models of effects of opiates and ethanol inpatient care. on T-cell injury.

CRISTINA SISON, PhD SAMUEL Z. SOFFER, MD MYOUNGSUN SON, PhD PHYLLIS W. SPEISER, MD Assistant Investigator Associate Professor Assitant Professor Associate Professor

Dr. Sison is a biostatistician Dr. Soffer studies mechanisms Dr. Son’s research interest is in Dr. Speiser’s research focuses with a focus multinomial of metastasis and resistance understanding inflammation, on congenital adrenal modeling, parametric to antiangiogenic therapies in inflammation resolution hyperplasia (CAH) and related bootstrap techniques, design pediatric soft tissue sarcomas. and providing therapeutics disorders, as well as childhood and analysis of clinical trials, The goal is to prevent micro- in systemic autoimmune growth, obesity and diabetes. issues in diagnostic testing, metastatic disease following diseases. Her current work regression modeling, and tumor resection in a host of focuses on the mechanisms longitudinal analysis, among pediatric solid tumors. of polarization of monocytes others. Her primary areas of by damage/pathogen- application include cardiology, associated molecular patterns immunology, endocrinology, (DAMPs/PAMPs) and C1q. rheumatology, infectious Her study will explore diseases, radiology and whether C1q-mimics can anesthesiology. resolve inflammation and potentially limit flares of autoimmune diseases.

Northwell Health 47 PHOEBE SPETSIERIS, PhD ALEX SPYROPOULOS, MD ADAM STEIN, MD BETTIE STEINBERG, PhD Investigator Professor Professor Professor

Dr. Spetsieris’ research focuses Dr. Spyropoulos studies the Dr. Stein’s research focuses Dr. Steinberg’s research is on incorporating novel neuro- prevention and treatment on osteoporosis in spinal primarily focused on diseases computational algorithms in of venous thromboembolic cord injury, management of of the airway caused by a versatile software package disease, including pulmonary spasticity and other aspects of human papillomaviruses for brain scan analysis and embolism, and has lead the medical management of (HPVs). One of these diseases visualization (ScAnVP) to multiple international clinical spinal cord disease. is recurrent respiratory study movement disorders trials in thromboembolic papillomatosis (RRP). She also such as Parkinson’s disease, disease. studies HPV-induced head Huntington’s disease and neck cancers. and dystonia, as well as a wide range of other neurodegenerative functional brain conditions.

JOEL STERN, PhD KEITH SCOTT SULTAN, MD JOLIEN SUURMOND, PHD ARUN SWAMINATH, MD Assistant Professor Assistant Professor Instructor Associate Professor

Dr. Stern’s current research Dr. Sultan’s major research Dr. Suurmond’s work is Dr. Swaminath’s areas of is focused on identifying interests include inflammatory focused on understanding interest include diet in the genetic and cellular bowel disease (IBD), i.e. autoantibody production and inflammatory bowel disease factors associated with Crohn’s disease and ulcerative plasma cell differentiation in (IBD), determining cause of neurological autoimmune colitis. He is the principal systemic lupus erythematosus death in IBD patients using diseases such as multiple investigator on multiple (SLE). Her goals are to the city and state department sclerosis, neuromyelitis optica investigator-initiated projects determine if heterogeneity of health databases, studying (NMO) and autoimmune including those evaluating in plasma cell differentiation the best treatments for IBD encephalitis. the relationship between IBD pathways can be used to complicated by Clostridium in different areas including stratify patients and develop difficile, and management opiate pain medication novel therapeutic targets. of iatrogenic injury in usage, opiate use indications, colitis patients. venous thromboembolism, microbiome analysis, dual therapy, disparities, myocardial infarction, Clostridium difficile infection and fatty liver.

48 Feinstein Institutes for Medical Research | 2018–2019 Annual Report MARC SYMONS, PhD ARUNABH TALWAR, MD CHRIS CHENGKE TANG, MD, MATTHEW TAYLOR, MD Professor Associate Professor PhD Instructor Assistant Professor

Dr. Symons has focused his Dr. Talwar studies Dr. Tang’s research focuses Dr. Taylor’s research focuses research on the molecular translational research in on utilizing brain imaging on the effects of prior dissection of signaling pulmonary medicine with techniques to study the infection on the response pathways that are responsible a focus on pulmonary functional pathways to sepsis. Specifically, he for tumor cell invasion hypertension and advanced and biomarkers for examines the role of T cell and survival, with current lung disease. He also neurodegenerative diseases activation and T cell memory emphasis on brain tumors. researches comorbidities (e.g., Parkinson’s disease in the modification to the The research focuses on of these diseases and their and Huntington’s disease) response of the immune two types of malignant impact on patients’ mental and other disorders (e.g., system and the body to severe tumors: glioblastoma and health and quality of life. Alzheimer’s disease, systemic inflammation, infection medulloblastoma. lupus erythematosus), aimed and sepsis along with T to improve the diagnostic cell development from the accuracy and assessment of neonatal period to adulthood. treatment effects for patients with these diseases.

SEWIT TECKIE, MD KEVIN TRACEY, MD JAMES TSANG, MPH IRA UDELL, MD Assistant Professor Professor Assistant Investigator Professor

Sewit Teckie, MD is a radiation Dr. Tracey’s research Mr. Tsang develops web- Dr. Udell is an oncologist and researcher focuses on inflammation, based, database-driven ophthalmologist with a practicing at Lenox Hill the physiological and applications that assist research focus on corneal Hospital. Her research focuses immunological response to researchers in accomplishing transplantation, DSAEK, on improving the quality infection and injury and the their data management tasks ocular infections and ocular of life outcomes of head mechanism by which neurons for large-scale NIH funded surface disorders. and neck cancer patients, control the immune system. multi-site clinical trials as well and testing novel digital Most recently, he has made as smaller single-site studies. technologies and clinical discoveries in bioelectronic innovations to enhance medicine, an emerging field patient care. of medicine that taps into the nervous system to treat disease and injury.

Northwell Health 49 OMOLARA UWEMEDIMO NEHAL VADHAN, MD SARAH RIVKAH ANDREA VAMBUTAS, MD MD, MPH Assistant Professor VAISELBUH, MD Professor Assistant Professor Assistant Professor

Dr. Uwemedimo has served as Dr. Vadhan’s research focuses Dr. Vaiselbuh specializes in Dr. Vambutas’s research a consultant for maternal and on the neuropsychological histiocytic disorders, pediatric interests are in the restoration newborn health initiatives in antecedents and leukemia and lymphoma and of natural hearing in patients Africa. Her current research consequences of substance her research focuses on stem with immune-mediated focuses on evaluating abuse, including cognitive, cell niche biology and the hearing loss who are resistant interventions to improve motivational and psychiatric tumor microenvironment. to conventional corticosteroid the quality of child health factors. Most recently, he has therapy. She is currently services and ultimately, health made discoveries in the acute studying how to prevent outcomes for children living in effects of smoked marijuana further hearing loss and sub-Saharan Africa. and their relationship to identify new biologic markers psychotic disorders. Heavy in these patients. marijuana use is a risk factor for psychotic illness.

ANNA VAN METER, PHD ASHA VARGHESE, PhD VINCENT VINCIGUERRA, MD ADRIANNA VLACHOS, MD Assistant Professor Associate Professor Professor Associate Professor

Dr. Van Meter’s research Dr. Varghese’s research Dr. Vinciguerra is an Dr. Vlachos’s research focuses focuses on subclinical and focuses on the effects of oncologist and active in on inherited bone marrow prodromal presentations of alcohol in the brain and clinical cancer research. failure syndromes, particularly mood disorders in youth, and the healing process of Diamond-Blackfan anemia on the factors that predict the skin wounds. (DBA). Her goal is to better trajectory of a young person understand the epidemiology at risk of developing a mood and biology of this red cell disorder. She is particularly disorder, and ultimately interested in the use of discover better diagnostic and technology to improve the treatment options. accuracy and speed of mood disorder diagnosis, in order to improve clinical services and facilitate access to evidence- based care.

50 Feinstein Institutes for Medical Research | 2018–2019 Annual Report AN VO, PhD BRUCE VOLPE, MD HAICHAO WANG, PhD JANICE WANG, MD Assistant Professor Professor Professor Assistant Professor

Dr. Vo’s research focuses on Dr. Volpe studies recovery Dr. Wang’s research is looking Dr. Wang’s research focuses developing imaging and after neurological injury with to uncover the mechanisms on cystic fibrosis (CF), analysis techniques for non-invasive technology underlying the pathogenesis pharmaceutical research trials the study of human brain including interactive robot of inflammatory diseases, investigating new medicines functions and structures training and transcranial including cerebral ischemic targeting the abnormal CF with magnetic resonance direct current stimulation injury and sepsis. He is transmembrane conductance imaging (MRI). (tDCS). His group is also working to identify novel regulator protein responsible exploring the effect of therapeutic targets to fight for the clinical manifestations repetitive trans-cranial against severe injury- and of CF as well as antibiotic and magnetic stimulation (rTMS) infection-elicited dysregulated airway clearance therapies for on brain metabolism using inflammation. CF-related lung disease. PET technology.

JASON WANG, PhD PING WANG, MD XIAO YAN MD, PhD HUAN YANG, MD Associate Professor Professor Assistant Investigator Associate Professor

Dr. Wang is a health Dr. Wang’s research goal is Dr. Yan’s research focuses Dr. Yang studies the immune economist, with extensive to develop better therapies on the activation and system and diseases caused experience in health care, to prevent septic onset and maturation of B-lymphocytes by inflammation, with a focus health equity, and health progression. His team is in health and disease, in on sepsis. Specifically, she economics research. studying several potential particular chronic lymphocytic studies the molecular basis His research focuses on drug candidates for the leukemia (CLL). of sepsis in order to develop population health, quality treatment of sepsis and an improved treatment improvement, clinical trials, other organ injuries including for sepsis. cost-effectiveness analysis, hemorrhagic shock, acute decision models, electronic kidney injury, ischemia- health record systems and reperfusion injury, stroke and related fields. radiation injury.

Northwell Health 51 WENG LANG YANG, PhD STAVROS ZANOS, PhD THEODOROS P. ZANOS, PhD JIANPING ZHANG, MD, PhD Professor Assistant Professor Assistant Professor Assistant Professor

Dr. Yang’s research focuses on Dr. Zanos focuses his Dr. Zanos’ research Dr. Zhang’s research goal studying cellular responses research on neural circuits interests span the areas of is to improve treatment and molecular mechanisms underlying integrative computational neuroscience, outcomes of patients with that cause organ damage autonomic function in neuroengineering and schizophrenia and other under various medical health and disease, adaptive neurophysiology. Recently, he psychiatric disorders. His conditions, and on developing neurostimulation of the has been working on projects current research is focused therapeutic interventions central and peripheral nervous involving neurostimulation on pharmacogenomics of to attenuate these system and bioelectronic that affects single neuron antipsychotic drug response, organ injuries. medicine therapies of firing, intracortical using genomic markers to immune, cardiovascular and oscillations, and connectivity predict medication efficacy neurological diseases. between brain areas, and side effects. He treats and sensory processing, learning studies patients with early and behavior. stages of schizophrenia.

MENG ZHANG, PhD XINHUA ZHU, MD YONG-RUI ZOU, PhD Assistant Professor Assistant Investigator Associate Professor

Dr. Zhang’s research interest Dr. Zhu’s research focuses Dr. Zou studies hematopoietic includes multilevel modelling, on identifying molecular stem cell (HSC) function longitudinal analysis, survival biomarkers of cisplatin- under normal and analysis, clinical trials, based chemo sensitivity for inflammatory conditions. meta-analysis and machine muscle-invasive bladder Another current focus is on learning. Currently, she cancer, identifying novel how inflammatory factors conducts research linking U.S. targets for prostate cancer affect the bone morrow Census Bureau census-tract therapy as well as conducting microenvironment and level socioeconomic data with clinical trials on therapies for differentiation of stromal patient-level data simply by metastatic breast, pancreatic cells in lymphoid organs in patient addresses, to identify and prostate cancer. autoimmune diseases. risk factors at both levels for treatment outcomes.

52 Feinstein Institutes for Medical Research | 2018–2019 Annual Report Financial summary For the year ending December 31, 2018 (unaudited dollars)

Grants $55,745,317 Licensing, royalties 4,189,579 and other Total revenue $121,183,280 Philanthropy and 61,248,384 health system support

Research $87,235,273 Administrative 19,469,967

Total expense Facilities and capital 14,478,039 $121,183,280 spending

Northwell Health 53 We are on an ambitious journey to reinvent health care and better the lives of the more than 2 million people we serve.

On October 17, 2018, we launched Northwell’s first than $3 million, bringing the total to more than $20 system-wide fundraising campaign, Outpacing the million in just 11 years. Impossible, with the goal to raise $1 billion by 2023. –– More than $300,000 in awards were distributed By the end of 2018 — just two short months after the to top female scientists during the seventh annual public launch — we reached the halfway milestone of Advancing Women in Science and Medicine (AWSM) more than $520 million, which includes all gifts since luncheon to celebrate and support excellence the campaign’s inception in 2016. and achievements of women in science. Since its inception in 2011, this program has distributed more Because we are driven to discover in our relentless than $1 million in support of Feinstein Institutes’ pursuit to make the impossible possible, research is female scientists. at the forefront of what our campaign will support. Additionally, the campaign will raise funds to build an Last year was an extraordinary year of philanthropic endowment program to support teaching and research support. Looking forward, we have a bold vision for initiatives — all for the benefit of our patients and the future of research and improving health care. This their families. report lays out this vision and focuses on our newly established five institutes that reflect our forward- As a nonprofit organization, we rely on the generosity thinking areas of excellence. This is an exciting and support of our communities to help us push our chapter for us, and philanthropy will continue to be an standards even further so we can provide the best care important driver of our growth. for every person we touch. Philanthropic contributions fuel innovation and allow our scientists, educators I am honored and excited to lead this organization and and clinicians to create new approaches, treatments I look forward to working to advance its mission and and therapies to keep the people in our communities promise. Thank you for your support, for believing in us well. Donor support also enables us to attract the and for sharing in our commitment to make health care best and brightest researchers in the country — and better tomorrow than it is today. the world — to join our outstanding physicians and scientists who are leading our work and reimagining how we practice medicine. Sincerely, Every gift to the Feinstein Institutes through this campaign matters and helps us fulfill our promise to our communities. Consider the following: –– Last year, we raised $39 million for research initiatives, which included the incredible growth of endowed gifts from Feinstein donors — more than $20 million — which will help us recruit Lewis Ranieri world-renowned talent and guarantee funding Chair, Board of Directors for research leadership posts that will propel the Feinstein Institutes for Medical Research Feinstein Institutes’ work even further. –– The annual Feinstein Institutes Summer Concert continues to be an important source of gifts to support research. Last year’s concert raised more

54 Feinstein Institutes for Medical Research | 2018–2019 Annual Report Board of Directors

David Acker Seth B. Lipsay

Robert B. Catell Edward D. Miller

Susan B. Claster Ralph A. Nappi

Steven M. Cohen Peter J. Pappas, Jr.

David E.R. Dangoor Lewis S. Ranieri

Michael A. Epstein Scott Rechler

Leonard Feinstein Jack J. Ross

Edward C. Forst Michael C. Slade

Lloyd M. Goldman Kevin J. Tracey, MD

Susan Karches Barbara Hrbek Zucker

Curt N. Launer

Bold denotes Chair

Honorary Directors

Anthony Cerami, PhD Nancy A. Marks

Nicholas Chiorazzi, MD Susan L. Merinoff

Thomas J. Degnan, MD

Northwell Health 55 2018 Honor Roll

Northwell Health is grateful for the continued support of so many friends. We wish to thank all of our donors whose generosity and ongoing partnership enable us to reimagine the world of health care and help us to take care of the Mr. and Mrs. Michael L. Ashner l communities we serve. Association for Macular We make every effort to be accurate and complete in this donor listing. If you Diseases have any questions with regard to how your name and/or organization appears, Drs. Donna and Mark Astiz  please contact the Northwell Health Foundation at 516-321-6300. AstraZeneca, LP The names listed below represent donors, corporations and foundations that have made cumulative gifts of $5,000 or more in 2018. Symbols appearing next to listings reflect Atalaya Capital Management lifetime giving. Dr. Lori Ann Attivissimo  Note: the data presented in this section does not capture financial information from Phelps Au Bon Pain Memorial Hospital, Northern Westchester Hospital or Peconic Bay Medical Center. Mr. and Mrs. Jeffrey C. Aurigema Auxiliary of North Shore A&D Entrances, LLC Dr. Patti and Mr. Brian Adelman American Mortgage University Hospital n u and Family  Consultants, Inc. Lorraine S. Aaron Mr. and Mrs. Matthew u Aaronson Rappaport Feinstein Mr. Paul R. Ades American Securities Bacchioni u Foundation u & Deutsch, LLP The Adikes Family BAE Systems Foundation u Amster, Rothstein & The Richard and Terez Abatecola Ms. Tara Baker Otto Foundation ADJO Contracting Corporation Ebenstein, LLP Balemian Family Foundation Mr. Steven Abbass Adria Infrastructure, LLC Mr. and Mrs. Arthur A. Anderman s Dr. Sandy Balwan and Abbott Vascular Aesthetic Plastic Surgery, P.C. u  Andersen Windows and Doors Mr. Paul Balwan Mr. Arthur A. Abeles AFCO Insurance Finance Mr. and Mrs. Jay I. Anderson Mr. and Mrs. Thomas M. Abilene, Inc. Mr. Greg A. Agran u Bancroft s Mr. and Mrs. Jonathan Andrews Abiomed, Inc. Ainslie Foundation Norwood Foundation, Inc. Andrews Foundation, Inc. ABM Industries, Inc. Airway, LLC Banfi Vintners Foundation s Anesthesia Management u s Mr. and Mrs. Michael Aboff Mr. Philip F. Alba Services, LLC Bank of America u Aboff’s, Inc. Mona Fishman Albert and Angels on the Bay, Inc. u Jeanine and Merrill Banks Andrew Albert s Abrams, Fensterman, The Anikstein Family u Lloyd Staffing Fensterman, Eisman, Formato, Mr. and Mrs. Wayne Albinder Anonymous BankUnited Ferrara, Wolf & Carone, LLP Mr. and Mrs. Michael W. l Mr. Michael Bapis Mrs. Lorraine Abramson l Alderman u Anonymous l  Barbash Family Fund, Inc. Louis and Anne Abrons Mr. and Mrs. John W. Anonymous l Foundation, Inc. Alexander u Anonymous u  Mrs. Cathy Barbash l Mr. Pasquale Acciarino Allergan Dr. Brahim Ardolic  Mrs. Lillian Barbash l Ace American Insurance Allscripts Mr. and Mrs. Alex L. Arker Mr. Shep Barbash l Company Ms. Maria Consuelo Almonte u Arthrex Mrs. Susan Barbash Mr. and Mrs. William Mr. and Mrs. Philip S. Altheim u Arthritis National Research Mr. and Mrs. Christopher J. Achenbaum l u Barber u Marianne and Paulson Foundation u Acker Family Charitable Fund Ambookan  ASCAP u Barclays Capital Dr. and Mrs. Angelo The Alvarenga Family  Mr. and Mrs. George Asch u Dr. Agnes and Acquista u  Mr. Thomas Barden  Asher Foundation Dr. Stephen Barone 

56 Feinstein Institutes for Medical Research | 2018–2019 Annual Report Lifetime Giving: H $10,000,000+ n $5,000,000 l $1,000,000 s $500,000 u $100,000 |  Northwell Employee

Mr. and Mrs. Manuel H. Blue Harbor Group, L.P. Mr. John M. Broder and Ms. The Capitano Foundation n Barron Blue Sky Real Estate Services & Karolyn Wallace Cardinal Health, Inc. s Mr. and Mrs. Daniel D. Barry Development Mr. and Mrs. Bert E. Brodsky Mr. and Mrs. Michael G. Mr. and Mrs. Stanley F. Mr. Eric S. Blumencranz s Alzheimer’s Foundation of Caridi l u Barshay BWD Group, LLC America The Vincent Gruppuso l  Mrs. Jean Baruch Mr. and Mrs. Marc J. Mr. and Mrs. David Brody Foundation Inc. Mrs. Sandra Atlas Bass H Blumencranz u Dr. Judith P. Brody and Dr. Bruce Mr. Joseph F. Carillo, Sr.  Mr. Ned H. Bassen Mr. and Mrs. Roger A. F. Farber Carillon Nursing & l Mr. Alan Batt Blumencranz Mr. Laurence Brody Rehabilitation Center Dr. David L. Battinelli  BWD Group, LLC Dr. and Mrs. Gerard X. Carle Place Union Free School Brogan, Jr.  District Mr. David W. Baum u Mr. and Mrs. Edward Blumenfeld and Family n Brooklyn Community The Carleigh Mac Foundation l The Bernard and Muriel Lauren l Foundation Foundation Mr. and Mrs. Andrew Boas Mr. and Mrs. Robert A. u Marjorie and Robert S. Boas n The Robert & Nancy Brooks Carlstrom Mr. and Mrs. Peter J. Baum Foundation, Inc. Dr. and Mrs. Richard S. Boas l Dr. Maria Torroella Carney and Mr. Kevin S. Beiner  Mr. and Mrs. Dayton T. Mr. Joseph M. Carney  Mr. and Mrs. John Bohlsen n l Dr. and Mrs. Steven Beldner  Brown, Jr. CARRA Mr. and Mrs. Geoffrey T. Boisi s  Stephen and Kim Bello  Dr. Zenobia Brown Carrier Corporation Mr. and Mrs. Al Bolivar  Dr. and Mrs. Alessandro G. Mr. George M. Browne Maxine and Hugh u Bellucci  Adam and Christina Boll  Ms. Susan Browning Carrington  u  Mr. Lawrence B. Benenson Dr. Vincent R. Bonagura  Boubour Bonnie Cashin Fund u The Benjamin Family Estate of Selma Borenstein Mr. and Mrs. Clyde Brownstone Ms. Kathryn Cashin  Dr. Nancy Beran  Mr. Jim Bosco  Mr. and Mrs. Bryan Brownyard Mr. and Mrs. Frank Castagna l Dr. Gayle Berg and Mr. and Mrs. John L. Bosco  Mr. and Mrs. Michael Broxmeyer Fifth Avenue of L.I. Realty u Mr. Al Berg Boston Scientific Doris Bry Trust l Associates s Mr. and Mrs. Paul Berger Corporation Bryan Cave Leighton Paisner LLP Robert, Carol and Caroline u  Ms. Aygun Berley Botto Mechanical BTG Pharmaceuticals Castano u Corporation u l The Berlin Family Foundation Ronald Burakoff, DMD and Mr. and Mrs. Robert B. Catell  Mr. and Mrs. Sidney Berman u Chris Boukas, MBA, RN Arlene Bregman, DRPH  Mr. Neil Cavuto Mr. Martin W. Bernard u Mr. and Mrs. Frank Boulton Agatha and John Burns & Century Elevator Maintenance  Family u Corporation Jill and Jay Bernstein Family Carol and Steven Boyer Foundation u The Brain Aneurysm Burns & McDonnell Engineering The Anthony Cerami and Ann u Company, Inc. Dunne Foundation for World Mr. and Mrs. Frank J. Foundation Health l Besignano u Mr. E. Steve Braun H Cablevision-Lightpath s Certainteed Bethpage Federal Credit Dr. and Mrs. Richard E. Dr. Jean M. Cacciabaudo and Union s Braunstein u  Dr. William A. Maiorino  Certilman Balin Adler & Hyman, LLP u Ms. Jennifer L. Bickhardt Mr. and Mrs. Fred Calamos Advisors, LLC u Mr. and Mrs. Sanjiv Chadha Biotronik, Inc. Brettschneider Caldera Medical, Inc. Clifford Chance US, LLP Dr. and Mrs. Adam Bridgehampton National Bank Mr. and Mrs. William J. Candee, III Bitterman  Dr. Derek Brinster  Ann and Peter Cannell u Ms. Lorraine Chambers Lewis  Dr. Victoria B. Bjorklund and The Bristal Assisted Living Jonathan S. Canno and Pierce Drs. Lucy and John Chang u Mr. Hank Bjorklund The Bristal at Lake Success Canno Roberts s s Mr. and Mrs. Robert W. Bloomingdale’s Brock Solutions Capital Interiors Chasanoff l

Northwell Health 57 The Elizabeth and Frank Chau Simon & Eve Colin Mr. and Mrs. William J. Mrs. Vincent de Roulet l Family Foundation Foundation, Inc. l Cunningham, III  Mr. Richard DeCastro Mr. and Mrs. Jay Chazanoff Community Foundation of Mr. F. Allan Curran Mr. James DeFranco u Mr. and Mrs. Edward A. Jackson Hole Michele and James Cusack  Marcella and Gianluigi Chernoff l Computershare Mr. and Mrs. Roderick H. De Geronimo  MARS Concerned Parents for AIDS Cushman s Peter & Jeri Dejana Family Research Chestnut Investors, LLC Drs. Patricia and Foundation u Estate of Gloria Slattery Fred Cushner  Mr. and Mrs. Michael Chi Mr. and Mrs. Frank J. DellaFera l Confort Custom Computer Specialists, Inc. CHIESI USA, Inc. Deloitte Services, LP s Dr. Joseph Conigliaro and Dr. Mr. Joseph Cusumano Children’s Medical Fund of Rosemarie Conigliaro  Delta Air Lines s New York H Mr. Robert Cuzzi Connecticut Sports Foundation Mr. and Mrs. Manfred E. Children’s Miracle Network Against Cancer, Inc. The Cypress Foundation, Inc. Demenus Hospitals H l Mr. and Mrs. Kevin B. Cystic Fibrosis Foundation Ms. Kathy DeRosa u Chipotle Mexican Grill Connolly  Drs. Catherine A. D’Agostino- Irving B. Deutschman Mr. and Mrs. Alan Chopp Mr. Thomas M. Conwell Barakat and Richard R. Foundation Barakat  Mr. and Mrs. Warren A. Dr. Gene F. Coppa  Dr. Barbara A. DeVoe  Christie u Mr. and Mrs. Ralph D’Ambrosio Corgan Associates Architects, P.C. Mr. and Mrs. Thomas E. Chubb Group of Insurance Mr. and Mrs. Gilbert J. D’Andrea Dewey, Jr. s Companies u Cornerstone Biopharma, Inc. Dr. and Mrs. John K. D’Angelo  S. Sydney DeYoung Mr. and Mrs. John Corrado u Cianna Medical, Inc. Jillian E. Daly Foundation u Foundation  Suffolk Transportation Dina E. Cicillini, RN, CPEN Damaghi Families l The Bruce and Sue Diamond Service, Inc. u Dr. Eric Cioe Pena  Charitable Foundation Mr. and Mrs. Konstantine Farahnaz and Babak Damaghi s Michael Diefenbach, PhD  Citigroup Costalas  Haleh and Kambiz Damaghi Rich and Debra Diem  RJ and Christos Dr. and Mrs. Peter Mitra and Nader Damaghi Civello-Bakolias  D. Costantino  Dr. Randolph and Shahnaz and Nasser Damaghi n Mrs. Melissa DiLorenzo  Mr. and Mrs. Mark L. Claster Mr. and Mrs. Bernard Costelli Mr. and Mrs. David E. R. Mr. and Mrs. Joseph Carl Marks Foundation, Inc. Ms. Eileen V. Costello u Dangoor DiMartino u Ms. Patti A. Clement Dr. and Mrs. James M. Daniel Gale MacCrate Dime Community Bank Ms. Kerry Clyne-Ivkovic  Crawford u  Real Estate, Inc. Dr. and Mrs. Yosef D. Credit Suisse Cohen Children’s Circle H Daniel Gale Sotheby’s Dlugacz  u Credit Union Miracle Day, Inc. International Realty Mrs. Gene W. Cohen Martin E. Doerfler, MD and  Hiram Cohen & Son, Inc. Crest Hollow Country Club at Frank and April Danza Kristin R. Huckshorn  Woodbury Mr. and Mrs. Ronald P. Cohen Morris & Rose Danzig Domain Integrated, LLC u Mr. and Mrs. Brad W. Cronin u Charitable Trust Ms. Sharon J. Cohen l Ms. Kathleen A. Donovan  Ms. Margaret M. Crotty and Mr. Bernard J. David Mr. and Mrs. Steven A. Mr. and Mrs. Thomas E. Mr. Rory B. Riggs s Cohen H Mr. Michel A. David-Weill Dooley n Ellen and Daniel Crown n  Mr. and Mrs. Steven M. Mr. Daniel Davies Doppelt Family Foundation u u The Crown Family Foundation Cohen Ms. Judy Davis Barbara Dorsch Foundation Eric Cruzen, MD and Christian The Charles Cohn Mrs. Katherine M. Davis Douglas Elliman Real Estate u  Foundation, Inc. u Sipaco l Davis Vision Visionworks Andrea Dowd and Crystal & Company Mr. and Mrs. Thomas L. Cole The De Rosa Foundation for Steven Ceely  Mr. and Mrs. John K. Mr. Richard Cunniff, Jr. Colon Cancer Research and Colgate, Jr. s Prevention u

58 Feinstein Institutes for Medical Research | 2018–2019 Annual Report Lifetime Giving: H $10,000,000+ n $5,000,000 l $1,000,000 s $500,000 u $100,000 |  Northwell Employee

Mr. and Mrs. Michael J. Epilepsy Study Consortium, Mr. Michael C. Fener  Fried, Frank, Harris, Shriver & Dowling u  Inc. u Jacobson, LLP Salvatore Ferragamo Robert N. and Nancy A. Mr. Michael Epstein l Mr. and Mrs. L. Keith Friedlander The Ferriday Fund Charitable Downey l Mr. and Mrs. Scott Erlich u Trust Claire Friedlander Family Donna and Robert Foundation The Boomer Esiason Mr. and Mrs. Sal Ferro  Drummond Foundation l Mr. and Mrs. Cliff Friedman u Alure Home Improvements u Ms. Helen Duryea Mr. and Mrs. Bernard Cold Spring Ventures, Inc. Dr. and Mrs. David H. Fields u  u Dystonia Medical Research Ettinger Dr. Karen A. Friedman  Foundation Mr. and Mrs. Joel A. Fierman Maryann Evans and Edwin G. Dr. and Mrs. Richard A. l Estate of Elizabeth A. Filer Eastern Waste Systems, Inc. Roos Friedman  Joel Finkelstein Cancer Trust of William Eaves Evercore Partners Services East, The Russell Friedman Law Foundation H The EBB Point Foundation L.L.C. Group, LLP Dr. Steven Fishbane  Edrington Americas Excel at Woodbury for The Gerald J. and Dorothy Rehabilitation & Nursing Mr. and Mrs. Michael G. Fisch u Edwards Lifesciences R. Friedman New Faegre Baker Daniels, LLP Mr. and Mrs. Daniel Fisher s York Foundation H Mr. Eugene J. Eichenberg u Mr. and Mrs. Peter M. Fahey u Dr. and Mrs. Nick Fitterman  Friends and Angels: The Tracy u The Einbinder Family “32” Vicere Foundation, Inc. Anne & Isidore Falk Charitable Dr. and Mrs. Adiel Fleischer  Eisai, Inc. Foundation n Mr. Scott H. Frishman u Florence Corporation u Mr. and Mrs. Saul Eisenberg Michael David Falk Philip J. Hahn Foundation n Flushing Bank The Charles L. Read Foundation Foundation Future Tech Enterprise, Inc. Mr. and Mrs. Sidney Forbes Mr. and Mrs. Warren Mr. and Mrs. David Fanning G2 Secure Staff Eisenberg l Fort Salonga Market, LLC Mr. and Mrs. Peter D. Fante Mr. and Mrs. Thomas J. u Mr. and Mrs. Robert Mr. and Mrs. Adam Elberg Mr. and Mrs. Steven Farbman u Gahan u Fortunoff u Mr. and Mrs. Christopher Eler Farrell Fritz, P.C. u Mr. Kenneth Gainer Dr. and Mrs. Richard N. Mr. Martin Elias l Ms. Patricia M. Farrell  Foster s Mr. Eugene K. Galbraith Ike, Molly & Steven Elias Fashion Accessories Benefit Ball Foundation for Surgical Mr. and Mrs. Gregory G. Foundation u The Louis and Gertrude Feil Fellowships u Galdi Thomas and Jeanne Elmezzi Family H Fan Fox and Leslie R. Samuels Gale International u Private Foundation H Ms. Amy Feinstein u Foundation, Inc. l Dr. Kathleen Gallo and Mr. EMI Music Publishing u  Mr. and Mrs. Jeffrey L. The Michael J. Fox Foundation Leonard L. Gallo Empire General Contracting Feinstein u for Parkinson’s Research s Gambino Medical & Science H Empire National Bank Mr. and Mrs. Leonard Mr. Michael Franco Foundation, Inc. Empire State Development l Feinstein H Mrs. Margrit Franitza Mr. and Mrs. Thomas F. Gambino, Sr. EnCap Investments, L.P. Mr. and Mrs. Richard S. Abraham B. & Sarah Frank Feinstein u s Mr. and Mrs. Leif Arntzen enCourage Kids Foundation s Fund Dory and Rich Feldman   Mr. and Mrs. Carl Gambino Jay B. Enden, MD  Douglas K. Frank, MD, FACS Mr. and Mrs. Michael E.  Mr. and Mrs. Thomas Endicott Management Company Mr. Edward C. Fraser Feldman u Gambino, Jr. Energy Capital Partners Mr. and Mrs. William H. Mr. and Mrs. Marshall Frazier u Mr. and Mrs. Andrew Rotondi Management, L.P. u Felenstein Howard L. and Judie Ganek Mr. and Mrs. Peter Engel u Freedom Mortgage Corporation Nicole and P.J. Felix  Philanthropic Fund l Mr. and Mrs. Leonard J. Enicoff Fresh Meadow Country Club Ms. Barbara Felker  Mr. and Mrs. Edward L. Gardner Ennead Architects LLP Mrs. Carolyn W. Fried Mr. Ron Felt Amit and Alpa Garg  Estate of Robert Entenmann H

Northwell Health 59 Mr. and Mrs. Peter E. Gaslow u Mr. and Mrs. Ralph Glogower u Grandstand Sports & Mrs. Souzan Hanna and Memorabilia, Inc. Dr. Nader Hanna  Empire Office Equipment Roy Henry Glover Memorial l Dr. and Mrs. Albert L. Granger Harborglow, Inc. George A. Gaston Charitable Trust Trust s GM Advisory Group, Inc. Graybar Electric Harding Real Estate, Ltd. Gates Capital Corporation Mr. and Mrs. Robert Goebert The Nancy A. Green Revocable Mr. Gregory Harlow Trust Gavin’s Got Heart Mr. Howard B. Gold  Dr. Yael Tobi Harris  Dr. Harly E. Greenberg  Mr. Michael J. Geiger Mr. and Mrs. Arthur H. Mortimer J. Harrison Trust u s Mr. and Mrs. Martin B. Mr. Richard L. Gelfond Goldberg Alan R. Hartman, MD u  Greenberg l Gene DX, Inc. Michael H. and Mr. Walter H. Haydock Alyson Goldberg  Mr. and Mrs. Alan I. Greene H Genentech, Inc. Mr. and Mrs. Stuart M. Mr. and Mrs. Robert M. The David and Alan Greene Hayim u Mr. and Mrs. Robert Genser Goldberg n Family Foundation, Inc. Mr. and Mrs. Ira Hazan l Ms. Gladys George and Dr. The Fay J. Lindner Foundation Mr. and Mrs. Richard M. Stuart Orsher s  u Dr. and Mrs. William A. u Greene Mrs. Mildred Golden Healy, III  Ms. Anne Gerken Blaine and Jayne Greenwald  Mr. Yoel Goldenberg The William Randolph Hearst Mr. and Mrs. Elbridge T. Greenwich Biosciences Foundations, Inc. l Gerry, Jr. u Ms. Dana J. Golding and Mr. Richard Scharf The Guenther E. Greiner The Hecht-Levi Foundation Richard S. Gershman & l Charitable Fund Associates, P.C. Goldman Sachs Heidell, Pittoni, Murphy & Bach, The Aryn and Matthew Mr. Jay Goldman l LLP u Mr. and Mrs. Fredric B. Gershon Grossman Foundation u Mr. and Mrs. Lloyd M. Benjamin J. Heitner, Mr. and Mrs. Melvin Gershon Dr. and Mrs. Michael B. Goldman H C.P. A ., P.C. u Mr. and Mrs. Raymond Gershon Grosso  The Joyce and Irving Goldman Dr. and Mrs. Lawrence Helfant The Gershwind Family Paul and Diane Guenther l Family Foundation Mr. and Mrs. Jonathan N. Foundation l Guggenheim Securities, LLC The Sol Goldman Charitable Helfat s Mr. and Mrs. George S. Getz l Trust Mr. and Mrs. Frank Gulden Alex and Yve Hellinger  Mrs. Ronnie P. Getz Mrs. Lola Goldring Mr. and Mrs. Arnold S. Henry Schein Cares Gumowitz Barrie-Getz Family Charitable Mr. and Mrs. Richard D. Foundation s Fund l Goldstein Mrs. Louise F. Gunderson Hercules Corporation Mr. and Mrs. Christopher C. u u Gordon & Silber, P.C. Dr. Leo A. Guthart Dr. and Mrs. Elliott B. Giamo u Mr. Lawrence Gottesman s Patricia and Edward Gutman l Hershman u  Dr. and Mrs. Gary Giangola  Lawrence Scott Events, Ltd. H.M. Hughes Co., Inc. Mr. and Mrs. Jerry Herz Mr. Louie Giaquinto Mr. and Mrs. Ronald A. The Marc Haas Foundation s Mr. and Mrs. William Hickey Estate of John V. Gibson u u Gottlieb Estate of Amy Hagedorn H MBH Foundation Mr. Vincent Giffuni l Mr. George E. Gottridge Mr.and Mrs. Allen A. Hakim Judy and William Hiltz l Gil-Bar Industries, Inc. Dr. JoAnne Gottridge-Patrizi and Halo Branded Solutions Mr. and Mrs. Randall S. Mrs. Gail Gilbert u Mr. Lester Patrizi u  u Mr. and Mrs. Douglas Hammond Hinden s The Clark Gillies Foundation l Mr. and Mrs. Fredric H. Gould  Mr. and Mrs. Richard C. Hand Dr. and Mrs. Jerrold E. Hirsch Drs. Michael and Cindy The Gould-Shenfeld Family Milton and Miriam Handler Dr. Judy I. Hirsch Gitman  Foundation Foundation s Mr. and Mrs. Peter J. Mr. and Mrs. Stephen J. Giuntini Paul E. and Sandra A. Graf l Hoffman u Charitable Fund Mr. Bernard Hann Mrs. Jeri L. Glaser Jeri Finesilver Cancer Mr. and Mrs. Steven R. Ms. Veronica Grandone u Glen Oaks Club, Inc. u Foundation Hoffman Mr. and Mrs. Mark A. Gloade 

60 Feinstein Institutes for Medical Research | 2018–2019 Annual Report Lifetime Giving: H $10,000,000+ n $5,000,000 l $1,000,000 s $500,000 u $100,000 |  Northwell Employee

Helen Hoffritz Charitable ISS Facility Services Inc. u John Kane, MD  Drs. Yashodhara and Sanjay Trust s Kirtane  Mr. Chander S. Iyer u Emily W. Kao  Hofstra University Mr. and Mrs. William H. Kissam Mr. Anthony T. Izzo u Dr. Barry M. Kaplan u  Mr. and Mrs. Ronald P. Pyramid Air Conditioning, Inc. Benefits Planning Corporation Mr. and Mrs. Neal S. Kaplan Hohmann Mrs. Virginia Mariani-Kitt and June Jacobs and Rochelle Silpe Mr. Ramesh Kapoor s Mr. and Mrs. Jeffrey H. Mr. Errol Kitt u Jacobs The Karches Foundation H Holtzman Kiwanis Pediatric Trauma Center The Sy & Felicia Jacobs The Honeysuckle Foundation for Dr. Corey Karlin-Zysman and Mr. Foundation l Charitable Fund u Warren Zysman  Children with Cancer The Nancy Klauber Forest Mr. Mark Jacobson l Christine and Andrew R. Mr. Harold M. Karten, II Foundation u  Mr. and Mrs. Mitchell L. Hong Mr. and Mrs. Mitchell B. Kase s Mr. Howard M. Kleet Jacobson l u Mr. and Mrs. James B. Hoover Kasowitz, Benson, Torres & Mr. and Mrs. Warren Kleet Mr. David Jakob Friedman, LLP Mr. and Mrs. Richard A. Dr. Victor R. Klein and Kathleen u Jam Kancer In The Kan Horowitz Kat’s Ribbon of Hope, Inc. u M. Csillag  Foundation Fund P&F Industries, Inc. Ms. Karen L. Katen Mr. and Mrs. Richard P. Janssen Biotech, Inc. Mr. Samuel T. Horowitz  Mr. and Mrs. Michael Katz l Kleinknecht s Dr. and Mrs. Mark P. Jarrett u  Mr. and Mrs. Stuart J. Horowitz Mrs. Phyllis Katz u Mrs. Marion Kleinkramer u J.C. Steel Corporation Mr. and Mrs. Randolph G. Mr. and Mrs. Saul B. Katz H KLS Martin, L.P.  Mr. and Mrs. Matthew Howard, Jr. Knapp Family Foundation l Jelavic  Mrs. Florence Kaufman n  Ms. Kathryn A. Howell Ms. Catherine Knips and Mr. JFK Air Ventures II JV Mr. and Mrs. Steven Estate of Samuel J. Hughes H Kaufman u Joseph Ferrara, Sr. JFK International Air Hugoton Foundation n Ms. Susan Knoepffler, RN  Terminal, LLC u Ms. Tara M. Kazak and Huntington Hospital - Mr. Fan Tao  Mr. and Mrs. David M. Knott u Mr. Dakis S. Joannou s Medical Staff Mr. and Mrs. John A. Kazickas u Kohl’s Cares l Grace Jones Richardson Estate of Frank Hutter u Testamentary Trust Mr. and Mrs. John C. Kean, III u Stephanie Kollar l Mr. and Mrs. M. Allan Hyman u Mr. and Mrs. Hoyle C. Jones Kean Development Susan G. Komen Greater New Ilberman Family Philanthropic Company, Inc. York City s Jones Lang Lasalle Americas u Fund Keefe, Bruyette & Woods, Inc. Karen M. Kostroff, MD and Jorge Family Mr. and Mrs. Richard C. Jon R. Cohen, MD u  Foundation Trust u Allan and Margaret Keene l Imbert Charitable Fund u Mr. Alexander Kouperman Mr. and Mrs. Elliott Joseph u Indus Valley Partners Mr. and Mrs. John P. Kelly Anastasios and Laura Sharon and Michael Joy  InfoHedge Technologies Mr. and Mrs. Marc Kemp u Kozaitis  The Joy in Childhood Mr. and Mrs. Francis Mr. and Mrs. Laurence A. Foundation Donald M. Kendall Sr. and Sigrid J. Ingrassia u R.V.C. Kendall Foundation Kraemer  J. Petrocelli Contracting, Inc. Intelli-Tec Security Services Mr. Charles Kenney  Kramer Levin Naftalis & JP Morgan Chase Bank l Frankel, LLP International Asbestos Mr. and Mrs. Michael I. Khan  Removal, Inc. Ann Jurdem Mr. Christopher Kraus Kids Connect Charitable Fund International Psychoanalytical Edward and Marjorie Jeffrey and Ellen Kraut  Goldberger Foundation Dr. Michael Kim  Association Mr. and Mrs. Cary A. Kravet l Mr. and Mrs. Harvey B. The David Kimmel Investors Bank Kravet, Inc. Kadden u Foundation u Investors Foundation, Inc Ms. Francine Kreuter Mr. and Mrs. Eric Kaltman s Natalie Bailey & Herbert J.  Dr. Tochi I. Iroku-Malize Kirshner Foundation Ms. Daphna D. Krim Mr. and Mrs. Fred Kamel Islanders Children’s Foundation Mr. and Mrs. Ralph M. Kube 

Northwell Health 61 Joseph Rees Kuh Charitable Dr. and Mrs. Lyle S. Long Island Jewish Medical Patricia Marcin, Esq. u u  Remainder Trust Leipziger Center - Medical Staff Mrs. Antonia Marcos u Society s Kunz Family Limited Partnership Mr. Barry Leistner Mr. Jeffrey A. Marcus The Kupferberg Foundation l Lencore Acoustics Corporation Long Island Real Estate Group u Dr. and Mrs. Joseph Marino  Jack & Dorothy Kupferberg Lenox Hill Medical Mario’s General Contracting Family Foundation l Anesthesiology, PLLC s Long Island Spine Specialists, P.C. Mr. and Mrs. Brian Marks Mr. and Mrs. Seth Mr. Evan Leonard l The Longhill Charitable Mr. and Mrs. George R. Marks Kupferberg The Lerner Family  Foundation, Inc. Ms. Susan Kwiatek  Mrs. Nancy A. Marks H Mr. and Mrs. Marc Lessner Mr. Glenn S. Lostritto Everett La Forge Trust The Nancy Lurie Marks Family Mr. and Mrs. David Lester 2200 Northern Steel, LLC Foundation s Lakeville Pace Mechanical, Inc. Levin Capital Strategies, LP Mr. and Mrs. James Loughlin Ms. Nancy Marquez Mejia Mr. and Mrs. Frank Lalezarian l n Mr. and Mrs. Arthur S. Levine LM & Co Marron Foundation Granite Building 2, LLC u Mr. and Mrs. Stuart R. Levine Dr. William M. Lowe  Dr. and Mrs. Bradley J. Marsh s Mony at Lake Success, LLC l The Leviton Foundation, Inc. Robin Ludwig Cohen JemCap, LLC Mr. and Mrs. Brian T. Lally  u Charitable Fund Estate of Leo J. Levy Mr. and Mrs. Peter J. Marsh u The Robert E. Landreth and Yali Li, PhD  Mr. Terry Lynam  Donna Landreth Family Fund s JemCap, LLC Mr. and Mrs. Randall A. Lico Mr. and Mrs. Patrick J. Lyons Mr. and Mrs. Jerry Landsberg u Brian P. and Gina M. Marshall Mr. and Mrs. George J. Liebner Steve and Sharron MacDonald Charitable Trust n Mr. and Mrs. Clifford P. Lane Family Foundation Mr. and Mrs. Martin Lifton l Mr. Steven H. Marvin l Mr. and Mrs. Jeffrey B. Lane Mr. and Mrs. James P. Lilling Family Fund for Neonatal Gertie F. Marx Private  MacGilvray Mr. Robert E. Lane Research u Foundation s Mrs. Lorraine R. Machiz l The Lanier Law Firm, P.C. Mr. and Mrs. Mark S. Lilling The Page & Otto Marx Mr. and Mrs. David S. Mack n s Larkfield IGA LLC Mr. and Mrs. Adam S. Lilling Foundation Mr. and Mrs. William L. Mack H Allison and Jed Laskowitz Mr. and Mrs. Matthew S. Lilling Mr. and Mrs. Frank P. u Winnie and Bill Mack  Marzano Mr. and Mrs. Andrew E. Laufer Seymour V. & Zena Lipkowitz Mr. and Mrs. Mark Lauria u Foundation, Inc. Irene Macyk, PhD, RN, Mr. Patrick Marzano NEA-BC  u The Alice Lawrence Mr. and Mrs. Seth B. Lipsay s Mr. Harold Matzner Madison Square Garden Foundation Inc. Jeffrey and Linda Lipton  Mr. Benjamin Mayer Mr. Edward A. Mafoud Ms. Maureen J. Lawrence, RN, The Litwin Foundation, Inc. H Mayer Brown, LLP BSN, CNML  Mr. David S. Magrone LiveOnNY Mr. and Mrs. Ronald J. Mazzucco Dr. and Mrs. Richard S. William K. Main, MD, P.C. Mr. and Mrs. James McCahill Lazzaro  Lizardos Mechanical & Electrical Engineering Diane and Darryl Mallah l James and Tara McCahill Family Mr. Paul Lebowitz s Lodging Solutions, LLC Manhasset Women’s Coalition Foundation Primary Care Ambulance Against Breast Cancer s Mr. and Mrs. F. J. McCarthy u Service Corporation Mr. and Mrs. Allen F. London Dr. Theodore Maniatis  341 Commack Road, Inc. Sol and Mildred Lederman London Fischer, LLP Mr. and Mrs. Alan J. Mann Supporting Foundation u Long Island Community Site Selection Advisory Group u Dr. and Mrs. Paul Lee  Foundation Teri Manno and Stacey Mr. and Mrs. James W. Amato  McCormack s Mr. and Mrs. Michael S. Leeds l Long Island Hearing & Speech Society u Mr. and Mrs. Ben Manu  Mr. and Mrs. Fred P. Mr. David W. Lehr Mr. John Z. Marangos McCready, Jr.  Mr. Thomas J. Marano

62 Feinstein Institutes for Medical Research | 2018–2019 Annual Report Lifetime Giving: H $10,000,000+ n $5,000,000 l $1,000,000 s $500,000 u $100,000 |  Northwell Employee

Mr. and Mrs. C. Richard Mr. and Mrs. Edward D. Mr. and Mrs. Robert Murray u Henry Nias Foundation, Inc. l McDaniel u Miller l Morris and Gertrude Furman Dr. Jeffrey Nicastro  Mrs. Marianne McDermott Dr. and Mrs. Larry S. Miller  Foundation Jamie Nicholls & Fran Biondi Mr. and Mrs. Patrick F. Mr. and Mrs. Richard Mr. Vincent P. Murray Charitable Trust McDermott u Miller  Mr. and Mrs. Alvin Murstein u Estate of Mary Niklas Mr. and Mrs. Kevin McGeachy  Mrs. Rona Miller Mr. and Mrs. Stanley Muss u Carole and Dr. Michael The McGinn Family  Mr. and Mrs. Sidney A. Miller u  Hyman and Ruth Muss Nimaroff John P. McGovern  Mr. and Mrs. Thomas Milone Foundation, Inc. North American Partners in n Mr. and Mrs. J. Stewart Mr. Stephen E. Milstein Mr. and Mrs. Robert J. Myers u Anesthesia, LLP McLaughlin u Dr. Bushra Mina  Dr. Jason J. Naidich  The North Beach Club, Inc. Victoria and Mark McLaughlin  Mind & Life Institute Dr. Souhel Najjar  North Shore Implant & Oral Mrs. Marybeth C. McManus  Surgery Associates The Nina Miness Ms. Rosemary J. Nalbone The McMillan Family  Revocable Trust North Shore University Hospital The Joe Namath Charitable - Medical Staff Society u Medtronic, Inc. u The David Minkin Foundation u Foundation u The Northern Trust Company Mr. Dennis Mehiel Mr. and Mrs. Ralph A. u  Northfield Bank R. K. Mellon Family Foundation Ms. Holly Minott Nappi Northfield Bank Foundation s Mr. Bruce G. Meltzer u The Mission Hospital Wendy and Tom Naratil  Northwestern Mutual Triangle Building Products Dr. and Mrs. Mark A. Drs. Tina and Raj K. Narayan Mittler u  Foundation Corporation Mr. and Mrs. Lenny Northwestern Mutual Wealth u Jacqueline Moline, MD, MSC  Nartowicz  Mr. and Mrs. Lewis S. Meltzer Management Company Estate of John P. Monaghan Nash Family Foundation H Millennium Foundation Trust Nouveau Elevator  Mr. Michael Mennella The Ambrose Monell Drs. Beth and Ira Nash Foundation l Mr. and Mrs. Edward M. Novick Dr. and Mrs. Alan R. Mensch  Mr. Boris Natenzon s The Penny Smith Novick Monster’s Kids u Dr. and Mrs. Andrew Mr. and Mrs. Raffiq Nathoo Foundation u The Don Monti Memorial W. Menzin  Nean Enterprises Inc. Research Foundation, Inc. H Ms. Bette Nussbaum Ms. Rita Mercieca  Mrs. Denise M. Francesca Stanfill Nye and Erin and Richard D. Monti u Mrs. Susan L. Merinoff H Neiditch-Breger Richard B. Nye l Caroline and Arthur Saladino Merkle, Inc. Mr. and Mrs. James L. Mr. and Mrs. William s Mr. and Mrs. Patrick Neisloss O’Connell  Estate of Harold Metal u Moravick  n Mrs. Ruth T. Nelkin Michael and Pamela Odlum  Metro-Star Contracting Morgan Stanley u Corporation Nelson Mullins Riley & Mr. and Mrs. Morris W. Offit Joe and Melissa Moscola  Scaraborough, LLP Metropolitan Commercial Bank Ms. Doreen M. O’Grady  Sara Moss and Neuberger Berman, LLC Mr. and Mrs. James E. Meyer Michael Gould s The Olin Family Mr. and Mrs. Gregg J. Nevola  Foundation, Inc. s Michael Kors (USA), Inc. Mr. and Mrs. Paul Mullins s The New York Community Mr. and Mrs. Stuart P. Olsten l Michaels Philanthropic Mr. Richard Mulry  Trust l Foundation s Once Upon a Time Susan Munro and Douglas New York Crohn’s Foundation s Drs. Michael F. and Mary Ann Borheck  Foundation l Michelis u  Mr. and Mrs. Kevin O’Neil Mr. and Mrs. Robert J. New York Fire Alarm Dr. Jennifer H. Mieres  Murphy  Association Inc. The John W. Engeman Theater Estate of Helen R. Miller Newman-Tanner Foundation Optum360, LLC  Mr. David Newton Marianne L. Oross, RN, MBA

Northwell Health 63 Dr. Viola Ortiz and Mr. and Mrs. Frank P. Patafio Mr. and Mrs. Warner Posen  Rampart Benefit Planning, Inc. Dr. James Kenny u  Sulabha and Nirav Patel, MD  Mr. and Mrs. Paul F. Posillico The Randolph Foundation Mrs. Barry M. Osborn The Paul Foundation Drs. Lenore and Louis Mr. and Mrs. Lewis S. Ranieri l u  Osteo Science Foundation Mr. and Mrs. Peter Pavlakis Potters Michael and Paula Rantz Mr. Daniel Ostersehlte PAX Assist, Inc. Dr. Purna Prasad and Veena Foundation Vijayendra  OTG Charities, Inc. PCORI n Mr. and Mrs. Charles Rappaport Premier Mechanical Services, Inc. Mr. and Mrs. Jonathan B. Nicholas Pedone Foundation u Drs. George Raptis and Otto u Presidio Networked Irene Draga  Ms. Ilene Penn Outerbridge Commons, LP Solutions, Inc. Estate of Arthur Rath u Penn Toyota, Ltd. Oxford Airport Technical The Louis & Harold Price Dr. Suzanne Ravitz-Nemshin u Services Mr. and Mrs. Arnold Foundation, Inc. and Mr. Jeff Nemshin S. Penner u u Oyster Bay Senior Residence, Inc. Price Waterhouse Coopers, LLP RBC Capital Markets, LLC Mr. Joseph Perella Richard and Lois Pace Charitable Professional Physical Therapy RC Structures, Inc. and Cultural Fund u Performance Trust Capital Project to Cure l Partners Frank J. Reali III Family The Michael Pachtman Donna Proske  Foundation, Inc. u Mr. and Mrs. Bruce D. Charitable Fund  Pergament s Protecting One Young Heart at a Mr. and Mrs. Thomas Reca Mr. and Mrs. Dennis L. Palmgren Time, Inc. Ms. Nora C. Perry  Mr. and Mrs. Bennett L. Wrightson Ramsing Foundation Phyllis L. Pullman u Rechler s Mrs. Sandra S. Pershing u Ms. Nancy Palumbo  Mr. and Mrs. Mark D. Purdy Mr. and Mrs. Donald Rechler s Mr. and Mrs. Jeffrey Persky PAN Long Island Pure Mr. and Mrs. Scott Rechler l s Challenge, Inc. u Ms. Patricia J. Petersen Pyramid Foundation, Inc. l Save the Starfish Foundation Mr. and Mrs. Attilio F. Dr. and Mrs. Joseph L. Pando  l Petrocelli H PyroSignal & Suppression, Inc. Mr. and Mrs. Charles Reichert Mr. and Mrs. Jason M. Pantzer Michael J. Pettei, MD, PhD  Queens College Foundation Charles and Helen Reichert Mr. and Mrs. James A. Pappas u Family Foundation Dr. Barrie L. Peyser and Questus Capital, LLC P.J. Mechanical Corporation Ms. Patricia Reimerdes u Mr. Eliot Peyser The Quinn Family  Mr. and Mrs. John D. Pappas u Dr. Carl D. Reimers  The Pfizer Foundation, Inc. l Mr. and Mrs. Nicholas Racanelli Mr. and Mrs. Peter J. Reliance Trading Corporation of PGA Tour, Inc. u Mr. Richard M. Racanelli u Pappas, Jr. s America Phase 3 Interiors, LLC Racanelli Construction P.J. Mechanical Corporation Drs. Maria and Company, Inc. The Phelan Foundation u  135 West 18th Street Realty Angelo D. Reppucci Charna Radbell Private Corporation Philips Ms. Brenda R. Rezak Foundation s Paragon Group, LLC Mr. and Mrs. John P. Picone Dr. Charlotte A. Rhee  Radiological Society of North u The Paramount Theatre, LLC Sharon and Rubin Pikus America Research & Education Drs. Dae-Sik and u Richard Rho u  Pariser Family Charitable Trust Pink Aid, Inc. Mr. John Raggio, Sr. and Dr. n Parkinson’s Foundation Mr. and Mrs. Ira Pittelman Donna Raggio Walter and Judith Rhulen Family Foundation Mr. and Mrs. A. Richard Plumbers Local Union, No. 200 Lindsay and John Raggio Richmond County Bar Parkoff l Plumbing Contractors Lauren Raggio Hall and Association Moses L. Parshelsky Association of LI, Inc. Kyle Hall Richmond County Savings Foundation u Dr. Carolyn Raia and Dr. Douglas PNC Institutional Asset l  Foundation Mr. and Mrs. Douglas S. Partrick Management Decorato  Richmond Pain Management ASC Dovedale Sales Corporation Mrs. Nancy Polk Mr. Greg Radinsky Richmond University Medical Dr. Michelle J. Portnof Dr. Ramanathan Raju  Mr. James Pascale Center

64 Feinstein Institutes for Medical Research | 2018–2019 Annual Report Lifetime Giving: H $10,000,000+ n $5,000,000 l $1,000,000 s $500,000 u $100,000 |  Northwell Employee

Dr. and Mrs. James J. Richter s Waterfall Asset Scaran Oil Service SEJ Properties L.P. Management LLC Company, Inc. u Mr. and Mrs. Dennis Riese l Mr. and Mrs. David Seligman  Mr. and Mrs. Laurence Roth l Mr. and Mrs. Dominick The Irene Ritter Foundation u Mr. Jon Sendach  Dr. and Mrs. Philip Roth  Scaringella Mr. and Mrs. Frank P. Rizzo  Mr. and Mrs. Stewart Senter u  Marcia and Philip Rothblum Mr. Michael Scarpelli Dr. David M. Roane  Ms. Marcela Sepe Foundation, Inc. Heather and Andy Schachter  Robert DeFalco Realty, Inc. Mr. Joshua Setton u Trust of Louise Rothschild Mary and Richard Schanler  Mr. and Mrs. Joseph Roberto u Mr. and Mrs. Robert C. u Mr. and Mrs. Richard J. Rouse Mr. and Mrs. Norman A. Setton s The Robin Hood Foundation l Schefer n Royal Waste Services, Inc. Seventh District Mr. and Mrs. Allan Rodolitz u Mr. and Mrs. Brian Ruane The Fay J. Lindner Foundation Association, Inc. u Roland’s Electric, Inc.  Mr. and Mrs. Barry Mr. Jonathan P. Scheidt SFA Agency, LLC Mr. and Mrs. James C. Romanelli H Rubenstein Cindy and S. Jacob Scheinerman, Dr. Nicholas Sgaglione  Dr. James N. Romanelli u  u MD u  Herbert Rubin, Esq. Shaare Shalom Synagogue Mr. and Mrs. Rosario P. Mr. and Mrs. Bernhard R. Mr. and Mrs. Michael Rubinberg Mr. and Mrs. John M. Shall Romanelli Schiel u The Louis and Rachel Rudin Mrs. Libby Shapiro u Dr. Paul P. Romanello and Dr. Foundation u Mrs. Deborah Schiff and Jamie A. Fortunoff  Dr. Russell Schiff  The Philip and Janet Shapiro The Florina Rusi-Marke Cancer u  Family Foundation, Inc. u The Umberto Romano and Foundation l Dr. Mark B. Schiffer Clorinda Romano Foundation, Inc. Mr. and Mrs. Robert S. u Mr. Norman Schlanger and Russo’s on the Bay Shapiro u  Mrs. Donna Rosen and Ms. Judith Kay l RXR Co. Property Mr. Glen Wolther u Mrs. Nancy S. Shea Management, LLC Mrs. Jill Schlanger-Kalogeras Jeannette and Jonathan Mr. and Mrs. Steven Shenfeld u u Dr. Charles and Mrs. Debra l Mr. and Mrs. Arthur F. Ryan Rosen Schleien  The Gould-Shenfeld Family Ryan Family Foundation The Abner Rosen Foundation Dr. and Mrs. Steven Foundation Edmond J. Safra Foundation l Admiral and Mrs. J. Schneider u  Dr. Bradley Sherman  l u Robert A. Rosen Mr. and Mrs. Michael H. Sahn Brooke and Steven B. Mr. Myron P. Shevell Schonfeld l Dr. Stacey E. Rosen and Sahn Ward Coschignano, PLLC Shock Society Dr. Mark K. Silverman  Ms. Sadie Schonfeld Mr. and Mrs. Mohammed Francis Shook Trust u Dr. David Rosenberg  Saleh Joseph and Janice Schulman  Mr. and Mrs. Arthur T. Shorin u Dr. and Mrs. Richard F. Dr. Jennifer M. Saleta and Mr. u Robin and Eric R. Schuss u Rosenberg David Saleta  Mr. and Mrs. Jeffrey Siegel Schwab Charitable Fund u Mr. Samuel W. Rosenblatt The Salice Family Foundation Ms. Merryl Siegel  Mr. and Mrs. Alan Siemens Medical Solutions Mr. and Mrs. Martin Sandler O’Neill & Partners, LP Schwalberg  u Health Services Corporation u Rosenman Ms. Rachel M. Sands Ms. Anna Schwartz u Katten Muchin Rosenman Mr. and Mrs. Steven C. Silva Sanford C. Bernstein & Co., LLC Dr. and Mrs. Foundation, Inc. The Louis and Martha Silver  Drs. Maria and Guillermo Benjamin Schwartz u Mr. and Mrs. Robert D. Foundation Santiago  The Lorraine and Richard Rosenthal l Dr. and Mrs. Peter Silver  The Lawrence and Carol Saper Schwarz Family Foundation Roslyn Union Free School Mr. and Mrs. Angelo J. Silveri u Foundation, Inc. Richard B. Schwarz, MD  District Alison and David Simon Sarah K. Linkie, MD, P.C. Mr. Tom Sclafani  Dr. and Mrs. Bernard M. Mr. and Mrs. Don Simon  Rosof u  Dr. and Mrs. Homayoun Mr. Robert M. Scoskie, II  Sasson  Mr. and Mrs. Richard Sims H Mr. and Mrs. George H. Ross l Mr. and Mrs. Gordon L. Kerri and Kevin Scanlon  Seaman, Jr. Mr. Gurvinder Singh Robin and Jack Ross l  Dr. Robert F. Scanlon  Securamerica, LLC. Dr. Varinder P. Singh u 

Northwell Health 65 Staten Island University Staten Island University Swim Across America u Mr. William B. Troy u Hospital - Service Auxiliary u Hospital - Medical & Dental Swing for Smiles l Mr. and Mrs. Charles M. n SK Foundation l Staff u Taffner Family Trunz Renee F. Stave and Mr. and Mrs. Michael C. Slade l Charitable Trust l Mr. and Mrs. Peter K. Tully u Howard D. Stave u Mr. and Mrs. Richard A. Slone l Takeda Pharmaceuticals Tully Construction Mr. Onisis Stefas  Dr. Kristofer L. Smith  Talisen Construction Company, Inc. Dr. Adam B. Stein and Dr. Fran R. Corporation Mr. Yaron Turgeman Dr. Lawrence G. Smith  Wallach-Stein  Taly Diamonds, LLC Turner Construction Dr. Mark L. Smith  Dr. and Mrs. Hermann Stein s Company u Mr. and Mrs. Michael S. Mr. and Mrs. Edward Tam Jane B. Stein l Smith s Drs. Monica and Neil Tanna Mr. and Mrs. Howard Tytel Jane and Frances Stein u  U.S. Bancorp Fund Services, LLC Estate of Raymond J. Smith Foundation H s Mr. and Mrs. Laurence Tarica l UCB Inc. Richard Mark Smith Fund Mrs. Judy Stein and u  Mr. and Mrs. Steven J. Smith Dr. Andrew Lipschitz Mrs. David S. Taylor Dr. Ira Udell l Snowlift, LLC u Estate of Lotte Steingart TD Ameritrade Clearing UJA-Federation of New York l Mr. and Mrs. Mark J. Mr. Murray Steingart TD Bank UMJCA INC.-GENERAL u Solazzo  Mr. and Mrs. Dr. and Mrs. Myron United Cabs, Inc. s Soros Fund Charitable Bertram Steinman s Teitelbaum United Fund of Manhasset, Inc s Foundation - Matching Gift u Step-by-Step Charitable Mr. William ten Broeke United Hospital Fund of Mr. Ramon Soto  Foundation Inc The Tepper Family New York l u Sottile & Megna, MD P.C. u Sterling Equities, Inc. Foundation United States-Israel Binational u Sound Point Capital Sterling National Bank The Torch Relay for CMN, Inc. Science Foundation Management The Lou and Harry Stern Family Thompson Land Services, Inc. United Way of Long Island s SouthWest Airlines Company Foundation Alisa Thorne, MD and Charles Unitex/A&P Coat, Apron &  u Spectranetics Mr. and Mrs. Russell N. Stern l Thorne, MD Linen Supply, Inc. Mrs. Leslie Spelke Mr. and Mrs. Steven S. Stern Thrasher Research Fund Upper East Side Rehabilitation l and Nursing Center Dr. Lawrence Spielberger & Mrs. Sybil Sternlieb Mr. and Mrs. Peter Tilles Dr. Jeffrey Vacirca  Dr. Greta Spanierman Family Joan K. Stout, RN l Edward R. Tinker Charitable Foundation Trust u New York Cancer & Blood Dr. and Mrs. Specialists Mr. and Mrs. Charles H. Theodore Strange u  Mr. and Mrs. Andrew H. Tisch Spielman l Ms. Lisa Valentine Edward K. Straus Fund u Tissuetech, Inc. Mr. Harold M. Spielman u Horace and Amy Mr. and Mrs. George Mr. and Mrs. Steven L. Tomback Mr. and Mrs. Robert A. Spielman Hagedorn Fund Strausman l The Townwide Fund of l Dr. Andrea Vambutas  St. Baldrick’s Foundation Mr. and Mrs. Edward H. Huntington u St. John’s University Streim l Toyota Motor North America, Van Deusen & Associates Erwin P. and Pearl F. Staller Subaru of America, Inc u Inc. - Corporate Giving Vanderlande Industries, Inc Program u Charitable Fund Suffolk Maintenance Service Mr. Vinson K. Varghese  Mr. Robert O. Stallone  Corporation Trailhead Institute Varnum-DeRose Charitable Staten Island Board of Sundheimer Foundation u Trane Company Remainder Annuity Trust Realtors, Inc. Super Shuttle H. Craig and Lora B. Treiber u Marianna Vazquez, RN  Staten Island Devildogs Mr. Eric Sutherland The Treiber Family Veejay Foundation u Foundation Foundation, Inc. s Mr. and Mrs. Fred Vicom Computer Services, Inc Staten Island Performing Sweetapple, Jr.  Tri-Star Construction Corp. Violette’s Cellar, LLC u Provider System, LLC

66 Feinstein Institutes for Medical Research | 2018–2019 Annual Report Lifetime Giving: H $10,000,000+ n $5,000,000 l $1,000,000 s $500,000 u $100,000 |  Northwell Employee

ViOptix, Inc. Maureen T. White  Mrs. Gilda S. Zirinsky u Visionworks of America, Inc. Whitehall Foundation, Inc. Mr. and Mrs. Marc D. Zisselman u Vista Equity Partners Mrs. Susan Wiener l Management LLC Mr. and Mrs. Donald Zucker H Mr. and Mrs. Stuart B. Wilkins s Vital Projects Fund, Inc. u Mr. Roy J. Zuckerberg H Rab Wilkinson Foundation u Ms. Carolyn M. Vivaldi  Willkie Farr & Gallagher, LLP Mr. and Mrs. Donald G. Vogel Mr. and Mrs. Robert B. Nassau Flyers Willumstad l Mr. Frederick A. Volk Mr. and Mrs. Fred Wilpon n Mr. and Mrs. Alex Wagman u Wilson Family Charitable Fund Dr. and Mrs. John R. Wagner u  Wilson, Elser, Moskowitz, u Dr. Tina J. Walch and Dr. Mitchell Edelman & Dicker, LLP Shuwall  Ann and Tony Wimpfheimer l Ira Waldbaum Family Mr. John G. Winchester Foundation u Dr. and Mrs. Nathaniel Wisch  Ellen M. Walker, Esq. and The Mr. and Mrs. M. Kenneth Honorable Paul Creditor Witover Mr. and Mrs. Emmett F. Mr. and Mrs. Arnold Wolowitz s Walker, Jr. u Women’s Club of Great Kills Mr. and Mrs. Bruce Waller s World Hellenic Biomedical Roberta Schaefer Family Association Foundation Worldwide Facilities, LLC Walsdorf Agency, Inc. Mr. Peter J. Worth u Mr. and Mrs. Stuart Walton Michael P. Wright and Peter J. Dr. Jason Wang and Newman  Ms. Bei Sheng  Mr. and Mrs. Henry T. Wu Ping Wang and Family  John Xikis Foundation, Inc. Mr. and Mrs. John A. Ward, III Dr. Andrew C. Yacht  Mr. and Mrs. Bradford G. Weekes u Dr. Mary A. Yatsinko Weil, Gotshal & Manges, LLP u Mrs. Lauren Yedvab  Theodore & Renee Weiler Dr. Benson Yeh  Foundation, Inc. u Estate of Joe Young Mrs. Pepi Weis u YourCause, LLC Mr. and Mrs. Ted D. Weiss M.B. & Edna Zale Foundation u T. Weiss Realty Corporation Zallinger/David Foundation Welltower Charitable The Bradley Zankel Foundation u Foundation, Inc. u Westat Mr. Leonard L. Zigelbaum u WGM Obstetrics & Ms. Laura Zimmerman Gynecology P.C. Mr. Ivan Q. Zinn Mr. Dennis P. Whalen  Ms. Judith A. Zipp Payson Wharton Legacy Society

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Anonymous (25) Mr. Willard H. DaSilva Mrs. Iris J. Katz Mr. Ralph A. Nappi Mr. John M. Simpson Mr. Roger E. Acker Mrs. Katherine M. Davis Mr. Saul B. Katz Mrs. Ruth T. Nelkin Mrs. Marion B. Simpson Mr. Paul R. Ades Mr. Maurice A. Deane Mr. Martin Kaufman Mr. Thomas Newman Ms. Mary Slavin Mr. Alex O. Aliksanyan Mrs. Elinor DeNicola Ms. Stephanie Kollar Ms. Judith Niebur Mrs. Merry Slone Mr. Philip S. Altheim Mr. Joseph DeNicola Mr. Cary A. Kravet Mrs. Ruth H. Norwood Mr. Richard A. Slone Mrs. Elizabeth Apelian Mrs. Lorinda P. de Roulet Mrs. Lisa Kravet Mrs. Elizabeth A. Perley Mrs. Margaret O. Small Mr. Gerald Appel Mr. Kevin J. Dwyer Mrs. Harriet Laxer Mr. John P. Picone, Jr. Mr. Theodore B. Smith, Jr. Mr. Stanley A. Mr. Eugene J. Eichenberg Mrs. Marion Leber Dr. Robert M. Pillar Mr. Harold M. Spielman Applebaum Mr. Lewis Eisenberg Mr. Steven Leber Mr. John Stephen Mrs. Joan Spiro Mr. Kenneth Asch Mr. Peter Engel Mrs. Linda Leshnick Popeleski Ms. Joan Hutcheson Mrs. Lillie G. Bain Ms. MaryAnn Evans Mr. Stephen Leshnick Mr. Warner Posen Stein Mr. Bernard Bartley Mr. Paul Farber Mrs. Sylvia M. Lester Dr. Daniel J. Powsner Mr. Murray Steingart Dr. Richard Berg Mr. Franklin Flower Mr. Donald I. Levin Ms. Phyllis L. Pullman Mr. Edward Stertz Mrs. Willa Bernhard Mrs. Anne Fried Mr. Arthur S. Levine Mr. Martin Rabinowitz Mrs. Frances Stertz Mr. Frank J. Besignano Dr. Gregory Fried Dr. Frederick W. Lipfert Mr. John Raggio, Sr. Mrs. E. Nancy Strausman Mrs. Laura Besignano Mr. Kenneth Gainer Ms. Catherine Lomuscio Mr. Gary Reed Mr. George Strausman Ms. Barbara Birnbaum Dr. Kathleen Gallo Mr. George M. Lyons Mr. Marc J. Reiss Mr. Carl J. Studer Mr. Norman E. Blankman Mr. Leonard L. Gallo Mrs. Lorraine R. Machiz Mrs. Arlene Richards Mr. Jay Tarantino Mr. Adrian T. Bogart, Jr. Mr. Albert Garshall Mr. Kevin Mahony Mr. H. Richard Roberts Mrs. Nancy B. Taylor Mr. Moe Bordwin Mr. J. Ronald Gaudreault Mr. Herbert Maletz Mr. Edwin G. Roos Mr. Robert Tremayne Mr. Murray Breidbart Mrs. Joan M. Gaudreault Mr. Howard Mann Mrs. Florence Rose Mrs. Ellen Tuchler Mr. Dayton T. Brown, Jr. Mr. Eugene L. Gazza Mrs. Naomi Mann Mr. Robert Rose Mrs. Mary D. Vessio Ms. Sandra Brown Mrs. Frances L. Gazza Mrs. Antonia Marcos Mr. Martin Rosenman Mr. Nicholas F. Vessio Mr. Simon Burton Ms. Helen Georgiadis Mrs. Diane Martakis Mrs. Jodi Rosenthal Mr. Frederick A. Volk Ms. Carole Kissel Mr. Edward M. Giles Mr. John Martakis Mr. Robert D. Rosenthal Mrs. Joan Wachtler Cameron Ms. Bernadette Goggin Ms. Lena Mazzarella Mrs. Doris Rosman The Honorable Sol Ms. Vera Capovilla Mr. Arthur H. Goldberg Ms. Rose Mazzarella Mrs. Adrienne Rosof Wachtler Mrs. Patricia Case Mrs. Candice Goldstein Mr. Ronald J. Mazzucco Dr. Bernard M. Rosof Mr. Paul E. Warburgh, Jr. Mr. Marvin Chaikin Mr. Richard D. Goldstein Mr. C. Richard McDaniel Mr. Jack J. Ross Mr. Robert W. Warburgh Ms. Lucy Chang Dr. Merrill Goodman Mr. James E. Meyer Mrs. Robin J. Ross Mrs. Pepi Weis Ms. Cathy Chen Mr. George E. Gottridge Mrs. Roberta Meyer Mrs. Karen Rothman Mr. Gabriel Wiesenthal Mr. Edward A. Chernoff Mr. Martin B. Greenberg Mr. Edward D. Miller Mr. Sheldon Rothman Mrs. Shoshanna Wingate Mrs. Dorothea Christie Mr. Alan I. Greene Mrs. Rona Miller Mr. Herbert Rubin Mr. Samuel H. Wolcott, III Mr. Warren A. Christie Mrs. Helen T. Greene Dr. Samuel L. Miller Mr. Edward S. Sacks Mr. Irving Zapinsky Mrs. Maria Ciccarelli Mr. Gerald Halpern Mr. Sidney A. Miller Mr. Henry Salzhauer Mr. Erwin Zeuschner Mr. Rocco Ciccarelli Mr. Carl D. Harnick Mrs. Elayne Mischna Ms. Janice Sands Mr. Werner J. Zumbrunn Mr. Jerry Clair Mrs. Elaine Hecht Mrs. Colette Mordo Mr. Dominick Scaringella Ms. Sharon J. Cohen Mr. Norman Hecht Mrs. Patricia Mullins Mrs. Peggy Scherr Mrs. Dulce M. Correa Mr. Arnold Holtzman Mr. Paul Mullins Ms. Janet Senecal Mr. Fidias N. Correa Mrs. Linda Holtzschue Mr. Charles Munro Mrs. Nancy S. Shea Ms. Tamela Corrieri Mrs. Johanna Hurwitz Mrs. Aileen J. Murstein Mr. Arthur T. Shorin Mr. Anthony Dalessio Mr. Chander S. Iyer Ms. Rosemary I. Nalbone Mrs. Beverly Shorin Mr. Joseph F. D’Angelo Mr. Jay Kaplowitz Mrs. Maureen L. Nappi Mr. Burton Simon

68 Feinstein Institutes for Medical Research | 2018–2019 Annual Report Designed and produced by Onward Publishing, Inc. 631-757-8300 www.onwardpublishing.com

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