Sustainable Development for The
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Meet the Faculty Candidates
MEET THE FACULTY CANDIDATES Candidates are displayed in alphabetically by last name. Prospective employers are invited to attend and while no event pre-registration is required however they must be registered for the BMES 2018 Annual Meeting. A business card will be required to enter the event. COMPLETE DETAILED CANDIDATE INFORMATION AVAILABLE AT www.bmes.org/faculty. Specialty - Biomaterials Alessia Battigelli Woo-Sik Jang Sejin Son John Clegg Patrick Jurney Young Hye Song R. Cornelison Kevin McHugh Ryan Stowers Yonghui Ding Yifeng Peng Varadraj Vernekar Victor Hernandez-Gordillo Shantanu Pradhan Scott Wilson Marian Hettiaratchi Eiji Saito Yaoying Wu Era Jain Andrew Shoffstall Specialty - Biomechanics Adam Abraham Vince Fiore Panagiotis Mistriotis Edward Bonnevie Zeinab Hajjarian Simone Rossi Alexander Caulk Xiao Hu Alireza Yazdani Venkat Keshav Chivukula Heidi Kloefkorn Rana Zakerzadeh Jacopo Ferruzzi Yizeng Li Specialty - Biomedical Imaging Mahdi Bayat Chong Huang Katheryne Wilson Zhichao Fan Jingfei Liu Kihwan Han Alexandra Walsh Specialty - BioMEMS Jaehwan Jung Aniruddh Sarkar Mengxi Wu Specialty - Cardiovascular Engineering Reza Avaz Kristin French Zhenglun (Alan) Wei Specialty - Cellular Engineering Annie Bowles Kate Galloway Kuei-Chun Wang Alexander Buffone Laurel Hind Mahsa Dabagh Matthew Kutys See other side for more candidates Specialty - Device Engineering (Microfluidics, Electronics, Machine-Body interface) Taslim Al-Hilal Brian Johnson David Myers Jungil Choi Tae Jin Kim Max Villa Haishui Huang Jiannan Li Ying Wang Specialty -
30 Years of Moving Individual Atoms
FEATURES 30 YEARS OF MOVING INDIVIDUAL ATOMS 1 2 l Christopher Lutz and Leo Gross – DOI: https://doi.org/10.1051/epn/2020205 l 1 IBM Research – Almaden, San Jose, California, USA l 2 IBM Research – Zurich,¨ 8803 Ruschlikon,¨ Switzerland In the thirty years since atoms were first positioned individually, the atom-moving capability of scanning probe microscopes has grown to employ a wide variety of atoms and small molecules, yielding custom nanostructures that show unique electronic, magnetic and chemical properties. his year marks the thirtieth anniversary of the publication by IBM researchers Don Eigler and Erhard Schweizer showing that individ- Tual atoms can be positioned precisely into chosen patterns [1]. Tapping the keyboard of a personal computer for 22 continuous hours, they controlled the movement of a sharp tungsten needle to pull 35 individ- ual xenon atoms into place on a surface to spell the letters “IBM” (Figure 1). Eigler and Schweitzer’s demonstration set in motion the use of a newly invented tool, called the scanning tunneling microscope (STM), as the workhorse for nanoscience research. But this achievement did even more than that: it changed the way we think of atoms. m FIG. 2: The STM that Don Eigler and coworkers used to position atoms. The It led us to view them as building blocks that can be tip is seen touching its reflection in the sample’s surface. (Credit: IBM) arranged the way we choose, no longer being limited by the feeling that atoms are inaccessibly small. with just one electron or atom or (small) molecule. FIG. -
Huda Y. Zoghbi, MD, Howard Hughes Medical Institute, Jan and Dan Duncan Neurological Research Institute at Texas Children’S Hospital and Baylor College of Medicine
Investigator Spotlight: Huda Y. Zoghbi, MD, Howard Hughes Medical Institute, Jan and Dan Duncan Neurological Research Institute at Texas Children’s Hospital and Baylor College of Medicine It is hard to believe that the 7th World Rett Syndrome Congress has come and gone with great success! Now with summer upon us, IRSF continues to move the spotlight to the committed scientists who have made the World Congress an impressive, high quality meeting with outstanding presentations and discussions. This month we are honored to focus on Dr. Huda Zoghbi who had co-chaired the Basic Research Symposium at the World Congress along with Dr. Gail Mandel. Together, they had produced an exciting lineup of speakers who were encouraged to present new, unpublished data in an effort to foster new ideas that will help chart the course for Rett syndrome research. Dr. Zoghbi is a Howard Hughes Medical Institute (HHMI) Investigator, the Director of the Jan and Dan Duncan Neurological Research Institute at Texas Children’s Hospital, and Professor of the Baylor College of Medicine in Houston, TX. She received her medical degree from Meharry Medical College and completed residency training in pediatrics and neurology at Baylor College of Medicine where she encountered her first Rett syndrome patient in 1983. Dr. Zoghbi was inspired to receive additional research training in the area molecular genetics and upon completion she joined the faculty of Baylor College of Medicine. In 1999, Dr. Zoghbi and collaborators including research fellow Ruthie Amir made a major breakthrough for Rett syndrome. They had discovered that mutations in MECP2, the gene encoding methyl-CpG-binding protein 2, causes Rett syndrome. -
UC San Diego UC San Diego Electronic Theses and Dissertations
UC San Diego UC San Diego Electronic Theses and Dissertations Title Spinocerebellar Ataxia Type 7 is Characterized by Defects in Mitochondrial and Metabolic Function Permalink https://escholarship.org/uc/item/02b7m809 Author Ward, Jacqueline Marie Publication Date 2016 Supplemental Material https://escholarship.org/uc/item/02b7m809#supplemental Peer reviewed|Thesis/dissertation eScholarship.org Powered by the California Digital Library University of California UNIVERSITY OF CALIFORNIA, SAN DIEGO Spinocerebellar Ataxia Type 7 is Characterized by Defects in Mitochondrial and Metabolic Function A dissertation submitted in partial satisfaction of the requirements for the degree Doctor of Philosophy in Biomedical Sciences by Jacqueline Marie Ward Committee in charge: Professor Albert La Spada, Chair Professor Eric Bennett Professor Lawrence Goldstein Professor Alysson Muotri Professor Miles Wilkinson 2016 Copyright Jacqueline Marie Ward, 2016 All rights reserved The Dissertation of Jacqueline Marie Ward is approved, and it is acceptable in quality and form for publication on microfilm and electronically: Chair University of California, San Diego 2016 iii DEDICATION This work is dedicated to my grandfather, Dr. Wayne Ward, the kindest person I’ve ever known. His memory inspires me to be a better person daily. iv TABLE OF CONTENTS SIGNATURE PAGE .......................................................................................... iii DEDICATION .................................................................................................. -
Elaine Fuchs
Women in Cell Science 4877 Elaine Fuchs FMW: How has your research career impacted on your personal life and vice Elaine Fuchs was born in the United versa? States and raised just outside Chicago. In 1972 she graduated with EF: My father was a geochemist who a B.S. and highest distinction in specialized in meteorites at Argonne the Chemical Sciences from the National Laboratories. My aunt, who University of Illinois. Her lived in the house next door, was a undergraduate thesis research in biologist at Argonne, and an ardent physical chemistry focused on the feminist. My sister, four years my senior, electrodiffusion of nickel through is now a neuroscientist. My mother is a quartz. She moved from Illinois to housewife, who loves gardening and Princeton University to study for her cooking and used to play piano and paint PhD in Biochemistry, investigating in oils. Growing up in such a family, and changes in bacterial cell walls during with farm fields, creeks and ponds in the sporulation in Bacillus megaterium. near vicinity, I developed a deep interest Elaine Fuchs in her lab in 1980. In 1977, she joined Howard Green, in science that has carried me through then at Massachusetts Institute my professional life. of Technology (MIT), for her If I think back to the family influences during Vietnam War protests. Although postdoctoral studies. There, she that shaped my choice of career, I my near perfect performances on tough focused on elucidating the remember that my Dad strongly physics and chemistry exams may have mechanisms underlying the balance advocated my being an elementary turned a few heads, I don’t feel that it between growth and differentiation in school teacher. -
Program Book
PARKINSON’SDISEASE2014 ADVANCING RESEARCH, IMPROVING LIVES PROGRAM MATERIALS Sponsored by: January 6 – 7, 2014 Natcher Conference Center National Institutes of Health Bethesda, MD About our cover: The program cover image is a stylized version of the Parkinson’s Disease Motor-Related Pattern (PDRP), an abnormal pattern of regional brain function observed in MRI studies which shows increased metabolism indicated by red in some brain regions (pallidothalamic, pontine, and motor cortical areas), and decreased metabolism indicated by blue in others (associated lateral premotor and posterior parietal areas). Original image used with permission of David Eidelberg, M.D. For further information see: Hirano et al., Journal of Neuroscience 28 (16): 4201-4209. Welcome Message from Dr. Story C. Landis Welcome to the National Institute of Neurological Disorders and Stroke (NINDS) conference, “Parkinson’s Disease 2014: Advancing Research, Improving Lives.” Remarkable new discoveries and technological advances are rapidly changing the way we study the biological mechanisms of Parkinson’s disease, identify paths to improved treatments, and design effective clinical trials. Elucidating mechanisms and developing and testing effective interventions require a diverse set of approaches and perspectives. The NINDS has organized this conference with the primary goal of seeking consensus on, and prioritizing, research recommendations spanning clinical, translational, and basic Parkinson’s disease research that we support. We have assembled a stellar and dedicated group of session chairs and panelists who have worked collaboratively to identify emerging research opportunities in Parkinson’s research. While we have divided our working groups into three main research areas, we expect each will inform the others over the course of the next two days, and we look forward to both complementary and unique perspectives. -
Huda Zoghbi: Taking Genetic Inquiry to the Next Level
Spectrum | Autism Research News https://www.spectrumnews.org NEWS, PROFILES Huda Zoghbi: Taking genetic inquiry to the next level BY RACHEL ZAMZOW 25 JUNE 2021 Listen to this story: Most mornings, Huda Zoghbi, 67, climbs a glass-encased, curling staircase to reach her lab on the top and 13th floor of the Jan and Dan Duncan Neurological Research Institute in Houston, Texas. The twisting glass tower, which she designed with a team of architects, echoes the double helix of DNA — a structure that has been central to her career-long quest to uncover genes underlying neurological conditions. As the institute’s director — and as a scientist— she is known for going beyond the standard job description. Genetics researchers often cast a wide net and sequence thousands of genes at a time. But in her prolific career, Zoghbi has focused on a handful of genes, methodically building up an understanding of their function one careful step at a time. Thanks to that approach, Zoghbi has made a number of landmark discoveries, including identifying the genetic roots of Rett syndrome, an autism-related condition that primarily affects girls, as well as the genetic mutations that spur spinocerebellar ataxia, a degenerative motor condition. She has authored more than 350 journal articles. Her accomplishments have earned her almost every major biology and neuroscience research award, including the prestigious Breakthrough Prize in 2017 and the Brain Prize in 2020. “She’s clearly the international leader in the field,” said the late Stephen Warren, professor of human genetics at Emory University in Atlanta, Georgia. Zoghbi never set out to lead a large research center, she says — her heart is in the lab. -
2016 Joint Meeting Program
April 15 – 17, 2016 Fairmont Chicago Millennium Park • Chicago, Illinois The AAP/ASCI/APSA conference is jointly provided by Boston University School of Medicine and AAP/ASCI/APSA. Meeting Program and Abstracts www.jointmeeting.org www.jointmeeting.org Special Events at the 2016 AAP/ASCI/APSA Joint Meeting Friday, April 15 Saturday, April 16 ASCI President’s Reception ASCI Food and Science Evening 6:15 – 7:15 p.m. 6:30 – 9:00 p.m. Gold Room The Mid-America Club, Aon Center ASCI Dinner & New Member AAP Member Banquet Induction Ceremony (Ticketed guests only) (Ticketed guests only) 7:00 – 10:00 p.m. 7:30 – 9:45 p.m. Imperial Ballroom, Level B2 Rouge, Lobby Level How to Solve a Scientific Puzzle: Speaker: Clara D. Bloomfield, MD Clues from Stockholm and Broadway The Ohio State University Comprehensive Cancer Center Speaker: Joe Goldstein, MD APSA Welcome Reception & University of Texas Southwestern Medical Center at Dallas Presidential Address APSA Dinner (Ticketed guests only) 9:00 p.m. – Midnight Signature Room, 360 Chicago, 7:30 – 9:00 p.m. John Hancock Center (off-site) Rouge, Lobby Level Speaker: Daniel DelloStritto, APSA President Finding One’s Scientific Niche: Musings from a Clinical Neuroscientist Speaker: Helen Mayberg, MD, Emory University Dessert Reception (open to all attendees) 10:00 p.m. – Midnight Imperial Foyer, Level B2 Sunday, April 17 APSA Future of Medicine and www.jointmeeting.org Residency Luncheon Noon – 2:00 p.m. Rouge, Lobby Level 2 www.jointmeeting.org Program Contents General Program Information 4 Continuing Medical Education Information 5 Faculty and Speaker Disclosures 7 Scientific Program Schedule 9 Speaker Biographies 16 Call for Nominations: 2017 Harrington Prize for Innovation in Medicine 26 AAP/ASCI/APSA Joint Meeting Faculty 27 Award Recipients 29 Call for Nominations: 2017 Harrington Scholar-Innovator Award 31 Call for Nominations: George M. -
Schedule of C Ourses
2017–2018 Schedule of Courses Schedule The David Rockefeller Graduate Program offers a Required reading: Molecular Biology of the Cell by Bruce Alberts et al.; Molecular Cell Biology by James E. Darnell et al. selection of courses, many of which students can Recommended reading: Basic Histology by Luiz Carlos Junqueira choose based on their interests and area of thesis et al. research. Organized by Rockefeller faculty, and taught Method of evaluation: Attendance, participation in the discussions, by scientists at the top of their fields, both from within student presentations, and a final oral exam and outside of the university, these courses are designed to provide a stimulating and dynamic curriculum that Cell Cycle Control students can tailor to fit their personal goals, in FREDERICK R. CROSS and HIRONORI FUNABIKI consultation with the dean of graduate studies. This seminar explores the current understanding of eukaryotic cell cycle control. Topics include the construction of a biochemical oscillator and overall structure of cell cycle control; positive and Biochemical and Biophysical Methods negative control of DNA replication; spindle morphogenesis and function; chromosome cohesion control; surveillance mechanisms SETH A. DARST and MICHAEL P. ROUT (checkpoints) monitoring spindle and DNA integrity; and control of This course presents the fundamental principles of biochemistry proliferation (start/restriction point control). The seminar relies heavily and biophysics, with an emphasis on methodologies. It addresses on studies in model organisms, but the emphasis throughout will be issues of protein and nucleic acid structure and the forces that on aspects of cell cycle control conserved among eukaryotes. underlie stability and govern the formation of specific three- Class length and frequency: 2.5-hour lecture and discussion, dimensional structures. -
An Eye to the Future Advances in Imaging Are Accelerating the Pace of Biological Discovery
fall 2007 An Eye to the Future Advances in imaging are accelerating the pace of biological discovery. A new cellular imaging initiative at the University has researchers seeing small and thinking big. story on page 8 p r o f i l e s college News c l a s s N o t e s from the dean Where curiosity- and solution- driven science meet ome scientists are driven by a curiosity to under- As a curiosity-driven college, it’s CBS’ job to keep S stand how life works—from molecules to eco- adding to the foundation of knowledge that supports systems—and to add to the world’s collective body of translational and solution-driven science in other col- knowledge. Others are searching for a puzzle piece leges. As such, we are the stewards of the foundational that may yield a better way to treat cancer, produce disciplines in the biological sciences: biochemistry, food or create renewable forms of energy. molecular biology, genetics, cell biology and develop- ment, ecology, plant biology, etc. Both are essential, and there is plenty of overlap Robert Elde, Dean between the two. Curiosity-driven research often turns In order to keep fueling translational and solution- up a bit of information that has immediate applications driven research, we need to infuse foundational disci- in medicine, agriculture or engineering. By the same plines with new technologies and other opportunities token, solution-driven research can add to knowledge. as science evolves. And some scientists travel between these two worlds. Fall 07 Vol. 5 No. 3 Cellular imaging, the subject of our cover story, is one As a whole, College of Biological Sciences faculty of those opportunities. -
Small Wonders, Endless Frontiers
Small Wonders, Endless Frontiers A Review of the National Nanotechnology Initiative Committee for the Review of the National Nanotechnology Initiative Division on Engineering and Physical Sciences National Research Council NATIONAL ACADEMY PRESS Washington, D.C. NOTICE: The project that is the subject of this report was approved by the Governing Board of the National Research Council, whose members are drawn from the councils of the National Academy of Sciences, the National Academy of Engineering, and the Institute of Medicine. The members of the committee responsible for the report were chosen for their special competences and with regard for appropriate balance. This material is based on work supported by the National Science Foundation under Grant No. CTS- 0096624. Any opinions, findings, and conclusions or recommendations expressed in it are those of the authors and do not necessarily reflect the views of the National Science Foundation. International Standard Book Number 0-309-08454-7 Additional copies of this report are available from: National Research Council 2101 Constitution Avenue, N.W. Washington, DC 20418 Internet, <http://www.nap.edu> Copyright 2002 by the National Academy of Sciences. All rights reserved. Printed in the United States of America Front cover: Three-dimensional scanning tunneling microscope image of a man-made lattice of cobalt atoms on a copper (111) surface. Courtesy of Don Eigler, IBM Almaden Research Center. Back cover: A nanoscale motor created by attaching a synthetic rotor to an ATP synthase. Reprinted with permission of the American Association for the Advancement of Science from Soong et al., Science 290, 1555 (2000). © 2000 by AAAS. -
Hhmi Bulletin 3 4 Hhmi Club
HHMI BULLETIN 4000 Jones Bridge Road • Chevy Chase, Maryland 20815-6789 Howard Hughes Medical Institute www.hhmi.org One Lump or Two? in this issue Once again, those fast-growing yeast find a way to turn a The Silicon Marvel long-held theory on its head. This time, it’s about prions, • Prions for Good which aren’t as universally nasty as once suspected. Some may actually help organisms evolve. The yeast colony shown here www.hhmi.org A Kaleidoscopic View contains a protein in its prion form. Because the prion, known as PSI+, is self-replicating and forms fibrous amyloids, the yeast look lumpy and bumpy—strikingly different from normally smooth yeast. Susan Lindquist’s group has found 19 yeast proteins that can switch back and forth between a normal and a prion version. The prions are thought to help the yeast adapt to changing conditions (see “A Silver Lining,” page 22). LIGHT MOVES v ol. 23 Heather True / Lindquist lab /no. 02 O b s e r v a t i O n s 16 Secret Agent MAn Skin cells do more than just cover our bodies. As a neurology resident, Stanley Prusiner saw Creutzfeldt–Jakob agent began to emerge. These data established, for the first time, that Keratinocytes, for example, anchor immune cells disease kill a patient in a matter of months. Researchers knew the rare a particular macromolecule was required for infectivity and that this within the epidermis, move and proliferate during neurodegenerative disease and scrapie, a similar disease in sheep, macromolecule was a protein …. wound healing, and even secrete inhibitory molecules were infectious but not as a result of a typical virus.