Acknowledgment of Reviewers, 2009
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Unesco High Panel on Science for Development
UNESCO HIGH PANEL ON SCIENCE AND TECHNOLOGY FOR DEVELOPMENT ** Attendees 15-16 September 2011 **Dr Atta-ur-Rahman President, Network of Academies of Science of Islamic Countries Distinguished National Professor of Chemistry, Karachi University Karachi, Pakistan **Dr Susan Avery President and Director, Woods Hole Oceanographic Institution Woods Hole, MA, USA **Dr Vijay Chandru Chief Executive Officer, Strand Life Sciences Bangalore, India Sir Partha Dasgupta Frank Ramsey Professor of Economics, University of Cambridge Cambridge, UK HRH Princess Sumaya bint El Hassan of Jordan President of the Royal Scientific Society Hashemite Kingdom of Jordan **HRH exceptionally to be replaced by Prof. Odeh Al-Jayyousi Vice-President of the Royal Scientific Society Hashemite Kingdom of Jordan Dr Rolf Heuer Director-General, CERN Geneva, Switzerland **Dr Sergei Kapitza Vice President, Academy of Natural Sciences, Russia Professor, Institute of Physics Moscow, Russia Dr Gong Ke President, Nankai University Tianjin, China **Prof. Dr Javier de Lucas Director, Cité internationale universitaire de Paris Paris, France **Prof. Dr Wolfram Mauser Dean of the Faculty of Geosciences Munich Ludwig Maximilian University 1 Munich, Germany **Prof. Gordon McBean Department of Geography, Social Science Centre The University of Western Ontario London, ON, Canada **Prof. Ahmadou Lamine N’Diaye President, African Academy of Sciences & President, National Academy of Science and Technology of Senegal Dakar, Senegal Prof. Tebello Nyokong Department of Chemistry Rhodes University -
Attachment 1
Appendix 1 Chemico-Biological Interactions 301 (2019) 2–5 Contents lists available at ScienceDirect Chemico-Biological Interactions journal homepage: www.elsevier.com/locate/chembioint An examination of the linear no-threshold hypothesis of cancer risk T assessment: Introduction to a series of reviews documenting the lack of biological plausibility of LNT R. Goldena,*, J. Busb, E. Calabresec a ToxLogic, Gaithersburg, MD, USA b Exponent, Midland, MI, USA c University of Massachusetts, Amherst, MA, USA The linear no-threshold (LNT) single-hit dose response model for evolution and the prominence of co-author Gilbert Lewis, who would be mutagenicity and carcinogenicity has dominated the field of regulatory nominated for the Nobel Prize some 42 times, this idea generated much risk assessment of carcinogenic agents since 1956 for radiation [8] and heat but little light. This hypothesis was soon found to be unable to 1977 for chemicals [11]. The fundamental biological assumptions upon account for spontaneous mutation rates, underestimating such events which the LNT model relied at its early adoption at best reflected a by a factor of greater than 1000-fold [19]. primitive understanding of key biological processes controlling muta- Despite this rather inauspicious start for the LNT model, Muller tion and development of cancer. However, breakthrough advancements would rescue it from obscurity, giving it vast public health and medical contributed by modern molecular biology over the last several decades implications, even proclaiming it a scientific principle by calling it the have provided experimental tools and evidence challenging the LNT Proportionality Rule [20]. While initially conceived as a driving force model for use in risk assessment of radiation or chemicals. -
ADA YONATH October, 2000
ADA YONATH - CURRICULUM VITAE May 21 Education 1959-1962 B.Sc. Chemistry, Hebrew University, Jerusalem, Israel 1962-1964 M.Sc. Biochemistry, Hebrew University, Jerusalem, Israel 1964-1968 Ph.D. X-ray crystallography, Weizmann Institute (WIS), Israel 1969 Post Doctoral Fellow, Mellon Inst. Pittsburgh, Pa., USA 1970 Post Doctoral Fellow, Dept. of Chemistry, MIT, Cambridge, MA, USA Professional Experience 1989- Director, the Kimmelman Center for Biomolecular Assemblies, WIS 1988- Kimmel Professor, Dept. of Structural Biology, WIS 1988-2004 Director, the Mazer Center for Structural Biology, WIS 1986-2004 Head, Max-Planck Research Unit, Hamburg, Germany 1989-1994 Chairperson, Dept. of Structural Chemistry & structural Biology, WIS 1984-1988 Associate Prof., Dept. of Structural Chemistry, WIS 1974-1983 Senior Scientist, Dept. of Structural Chemistry, WIS 1979-1983 Visiting Prof., Max-Planck Inst. for Mol. Genetics, Berlin, Germany 1978 summer Visiting Prof., Universidad Austral de Chile, Valdivia, Chile 1977-1978 Visiting Scientist, Biophysics, University of Chicago, IL, USA 1974 Visiting Scientist, Dental School, University of Alabama, USA 1971-1977 Consultant: The Open University, Israel 1971-1978 Lecturer, Tel-Aviv & Ben Gurion Uni, Israel 1970-1974 Scientist, Dept. of Chemistry, WIS Member of the USA National Academy of Sciences Member of the Israeli Academy of Sciences and Humanities Member of the Royal Society, London Member of the Leopoldina, German Academy for Sciences Member of the European Molecular Biology Organization (EMBO) Member -
The Cathedral Priory of St. Andrew, Rochester
http://kentarchaeology.org.uk/research/archaeologia-cantiana/ Kent Archaeological Society is a registered charity number 223382 © 2017 Kent Archaeological Society THE CATHEDRAL PRIORY OF ST. ANDREW, ROCHESTER By ANNE M. OAKLEY, M.A. THE church of St. Andrew the Apostle, Rochester, was founded by Ethelbert, King of Kent, as a college for a small number of secular canons under Justus, Bishop of Rochester, in A.D. 604. Very httle is known about the history of this house. It never seems to have had much influence outside its own walls, and though it possessed considerable landed estates, seems to have been relatively small and poor. It also suffered at the hands of the Danes. Bishops Justus, Romanus, Pauhnus and Ithamar were all remarkable men, but after Bishop Putta's transla- tion to Hereford in 676, very Httle is heard of Rochester. Their bishop, Siweard, is not mentioned as having been at Hastings with King Harold as were many of the Saxon bishops and abbots, and the house put up no opposition to William I when he seized their lands and gave them to his half brother Odo, Bishop of Bayeux, whom he had created Earl of Kent. The chroniclers say that the house was destitute, and that, when Siweard died in 1075, it was barely able to support the five canons on the estabHshment.1 Four years after his conquest of England, Wilham I invited his friend Lanfranc, Prior of Caen and a former monk of Bee in Normandy, to be bis archbishop at Canterbury. Lanfranc's task was specific: to reorganize EngHsh monasticism on the pattern of Bee; to develop a strict cloistered monasticism, but one of a kind that was not entirely cut off by physical barriers from the Hfe of the rest of the church. -
Female Fellows of the Royal Society
Female Fellows of the Royal Society Professor Jan Anderson FRS [1996] Professor Ruth Lynden-Bell FRS [2006] Professor Judith Armitage FRS [2013] Dr Mary Lyon FRS [1973] Professor Frances Ashcroft FMedSci FRS [1999] Professor Georgina Mace CBE FRS [2002] Professor Gillian Bates FMedSci FRS [2007] Professor Trudy Mackay FRS [2006] Professor Jean Beggs CBE FRS [1998] Professor Enid MacRobbie FRS [1991] Dame Jocelyn Bell Burnell DBE FRS [2003] Dr Philippa Marrack FMedSci FRS [1997] Dame Valerie Beral DBE FMedSci FRS [2006] Professor Dusa McDuff FRS [1994] Dr Mariann Bienz FMedSci FRS [2003] Professor Angela McLean FRS [2009] Professor Elizabeth Blackburn AC FRS [1992] Professor Anne Mills FMedSci FRS [2013] Professor Andrea Brand FMedSci FRS [2010] Professor Brenda Milner CC FRS [1979] Professor Eleanor Burbidge FRS [1964] Dr Anne O'Garra FMedSci FRS [2008] Professor Eleanor Campbell FRS [2010] Dame Bridget Ogilvie AC DBE FMedSci FRS [2003] Professor Doreen Cantrell FMedSci FRS [2011] Baroness Onora O'Neill * CBE FBA FMedSci FRS [2007] Professor Lorna Casselton CBE FRS [1999] Dame Linda Partridge DBE FMedSci FRS [1996] Professor Deborah Charlesworth FRS [2005] Dr Barbara Pearse FRS [1988] Professor Jennifer Clack FRS [2009] Professor Fiona Powrie FRS [2011] Professor Nicola Clayton FRS [2010] Professor Susan Rees FRS [2002] Professor Suzanne Cory AC FRS [1992] Professor Daniela Rhodes FRS [2007] Dame Kay Davies DBE FMedSci FRS [2003] Professor Elizabeth Robertson FRS [2003] Professor Caroline Dean OBE FRS [2004] Dame Carol Robinson DBE FMedSci -
The 2018 Chemistry Prize
Nobel Prize Lessons Teacher’s manuscript – the 2018 Chemistry Prize The Nobel Prize in Chemistry • The Nobel Prize in Chemistry is one of the five prizes founded by Alfred Nobel and awarded on December 10 every year. • Before Nobel died on December 10, 1896, he wrote in his will that the largest part of his fortune should be used to fund a prize to those who “have conferred the greatest benefit to humankind.” One of the five prizes should go to “the person who made the most important chemical discovery or improvement”. Who is rewarded with the Chemistry Prize? • The Nobel Prize in Chemistry is thus awarded to people who have made discoveries or improvements that have given us knowledge about the structure of various substances and how they are created and changed – how and why they react with each other, and even how we can create new molecules. • This is Ada Yonath, who was awarded the 2009 Nobel Prize in Chemistry for her pioneering contributions to studies of the ribosome. • Other Chemistry Prizes have been awarded to: • Marie Curie, for the discovery of radioactive elements, and Dorothy Crowfoot Hodgkin, for the discovery of the structure of penicillin. The 2018 Chemistry Prize • Two of this year’s Laureates in Chemistry have developed methods for producing new enzymes and antibodies in the lab. These enzymes can be used to speed up chemical reactions, and the antibodies can be used to produce pharmaceuticals. The Laureates’ methods are based on randomly creating numerous variants of a protein, testing how the different variants work and then selecting the protein that works best – a process known as “directed evolution”. -
Monitoring Synaptic and Neuronal Activity in 3D with Synthetic And
Journal of Neuroscience Methods 222 (2014) 69–81 Contents lists available at ScienceDirect Journal of Neuroscience Methods jou rnal homepage: www.elsevier.com/locate/jneumeth Basic Neuroscience Monitoring synaptic and neuronal activity in 3D with synthetic and genetic indicators using a compact acousto-optic lens two-photon microscopeଝ Tomás Fernández-Alfonso, K.M. Naga Srinivas Nadella, M. Florencia Iacaruso, ∗ Bruno Pichler, Hana Ros,ˇ Paul A. Kirkby, R. Angus Silver Department of Neuroscience, Physiology and Pharmacology, University College London, London WC1E 6BT, UK h i g h l i g h t s g r a p h i c a l a b s t r a c t • We expand the utility of acousto- optic lens (AOL) 3D 2P microscopy. • We show rapid, simultaneous moni- toring of synaptic inputs distributed in 3D. • First use of genetically encoded indicators with AOL 3D functional imaging. • Measurement of sensory-evoked neuronal population activity in 3D in vivo. • Strategies for improving the mea- surement of the timing of neuronal signals. a r t i c l e i n f o a b s t r a c t Article history: Background: Two-photon microscopy is widely used to study brain function, but conventional micro- Received 26 June 2013 scopes are too slow to capture the timing of neuronal signalling and imaging is restricted to one plane. Received in revised form 22 October 2013 Recent development of acousto-optic-deflector-based random access functional imaging has improved Accepted 26 October 2013 the temporal resolution, but the utility of these technologies for mapping 3D synaptic activity patterns and their performance at the excitation wavelengths required to image genetically encoded indicators Keywords: have not been investigated. -
Beendigung Der Entzündungsreaktion Durch Interleukin-9 Sezernierende
Beendigung der Entz¨undungsreaktion durch Interleukin-9 sezernierende angeborene Lymphozyten Der Naturwissenschaftlichen Fakult¨at der Friedrich-Alexander-Universit¨at Erlangen-Nurnberg¨ zur Erlangung des Doktorgrades Dr. rer. nat. vorgelegt von Simon Rauber Als Dissertation genehmigt von der Naturwissenschaftlichen Fakult¨at der Friedrich-Alexander-Universit¨at Erlangen-Nurnberg¨ Tag der mundlichen¨ Prufung:¨ 02. 05. 2919 Vorsitzender des Promotionsorgans: Prof. Dr. Georg Kreimer Gutachter: Prof. Dr. Steffen Backert Prof. Dr. Georg Schett Resolution of inflammation by interleukin-9 producing innate lymphoid cells To the Faculty of Natural Sciences of the Friedrich-Alexander-University Erlangen-Nuremberg for the obtainment of the academic degree doctor rerum naturalium (Dr. rer. nat.) submitted by Simon Rauber Approved by the Faculty of Natural Sciences of the Friedrich-Alexander-University Erlangen-Nuremberg Date of oral examination: 02. 05. 2019 Chairman of examination board: Prof. Dr. Georg Kreimer Referees: Prof. Dr. Steffen Backert Prof. Dr. Georg Schett Table of contents 1 Deutsche Kurzfassung1 2 English abstract3 3 Introduction 5 3.1 Innate lymphoid cells and the bridge between primary and adaptive immune response6 3.1.1 The discovery . .7 3.1.2 The classification of innate lymphoid cells and their integration into the im- mune system . 11 3.1.3 Are innate lymphoid cells only innate mirrors or fully-fledged immune cells . 12 3.2 The interleukin-9 . 15 3.2.1 The cellular source of interleukin-9 . 15 3.2.2 The immune-modulatory capacities of interleukin-9 . 17 3.2.2.1 Interleukin-9 in infection, tumour and allergy . 18 3.2.2.2 Interleukin-9 in autoimmune diseases . -
Moore Noller
2002 Ada Doisy Lectures Ada Doisy Lecturers 2003 in BIOCHEMISTRY Sponsored by the Department of Biochemistry • University of Illinois at Urbana-Champaign Dr. Peter B. 1970-71 Charles Huggins* and Elwood V. Jensen A76 1972-73 Paul Berg* and Walter Gilbert* Moore 1973-74 Saul Roseman and Bruce Ames Department of Molecular carbonyl Biophysics & Biochemistry Phe 1974-75 Arthur Kornberg* and Osamu Hayaishi Yale University C75 1976-77 Luis F. Leloir* New Haven, Connecticutt 1977-78 Albert L. Lehninger and Efraim Racker 2' OH attacking 1978-79 Donald D. Brown and Herbert Boyer amino N3 Tyr 1979-80 Charles Yanofsky A76 4:00 p.m. A2486 1980-81 Leroy E. Hood Thursday, May 1, 2003 (2491) 1983-84 Joseph L. Goldstein* and Michael S. Brown* Medical Sciences Auditorium 1984-85 Joan Steitz and Phillip Sharp* Structure and Function in 1985-86 Stephen J. Benkovic and Jeremy R. Knowles the Large Ribosomal Subunit 1986-87 Tom Maniatis and Mark Ptashne 1988-89 J. Michael Bishop* and Harold E. Varmus* 1989-90 Kurt Wüthrich Dr. Harry F. 1990-91 Edmond H. Fischer* and Edwin G. Krebs* 1993-94 Bert W. O’Malley Noller 1994-95 Earl W. Davie and John W. Suttie Director, Center for Molecular Biology of RNA 1995-96 Richard J. Roberts* University of California, Santa Cruz 1996-97 Ronald M. Evans Santa Cruz, California 1998-99 Elizabeth H. Blackburn 1999-2000 Carl R. Woese and Norman R. Pace 2000-01 Willem P. C. Stemmer and Ronald W. Davis 2001-02 Janos K. Lanyi and Sir John E. Walker* 12:00 noon 2002-03 Peter B. -
Physical Determinants of Vesicle Mobility and Supply at a Central
RESEARCH ARTICLE Physical determinants of vesicle mobility and supply at a central synapse Jason Seth Rothman1, Laszlo Kocsis2, Etienne Herzog3,4, Zoltan Nusser2*, Robin Angus Silver1* 1Department of Neuroscience, Physiology and Pharmacology, University College London, London, United Kingdom; 2Laboratory of Cellular Neurophysiology, Institute of Experimental Medicine, Hungarian Academy of Sciences, Budapest, Hungary; 3Department of Molecular Neurobiology, Max Planck Institute of Experimental Medicine, Go¨ ttingen, Germany; 4Team Synapse in Cognition, Interdisciplinary Institute for Neuroscience, Universite´ de Bordeaux, UMR 5297, F-33000, Bordeaux, France Abstract Encoding continuous sensory variables requires sustained synaptic signalling. At several sensory synapses, rapid vesicle supply is achieved via highly mobile vesicles and specialized ribbon structures, but how this is achieved at central synapses without ribbons is unclear. Here we examine vesicle mobility at excitatory cerebellar mossy fibre synapses which sustain transmission over a broad frequency bandwidth. Fluorescent recovery after photobleaching in slices from VGLUT1Venus knock-in mice reveal 75% of VGLUT1-containing vesicles have a high mobility, comparable to that at ribbon synapses. Experimentally constrained models establish hydrodynamic interactions and vesicle collisions are major determinants of vesicle mobility in crowded presynaptic terminals. Moreover, models incorporating 3D reconstructions of vesicle clouds near active zones (AZs) predict the measured releasable pool size and replenishment rate from the reserve pool. They also show that while vesicle reloading at AZs is not diffusion-limited at the onset of release, *For correspondence: nusser@ diffusion limits vesicle reloading during sustained high-frequency signalling. koki.hu (ZN); [email protected] DOI: 10.7554/eLife.15133.001 (RAS) Competing interests: The authors declare that no competing interests exist. -
Implicit Particle Filters for Data Assimilation Alexandre Chorin, Matthias Morzfeldand Xuemin Tu
Communications in Applied Mathematics and Computational Science IMPLICIT PARTICLE FILTERS FOR DATA ASSIMILATION ALEXANDRE CHORIN, MATTHIAS MORZFELD AND XUEMIN TU vol. 5 no. 2 2010 mathematical sciences publishers COMM. APP. MATH. AND COMP. SCI. Vol. 5, No. 2, 2010 IMPLICIT PARTICLE FILTERS FOR DATA ASSIMILATION ALEXANDRE CHORIN, MATTHIAS MORZFELD AND XUEMIN TU Implicit particle filters for data assimilation update the particles by first choosing probabilities and then looking for particle locations that assume them, guiding the particles one by one to the high probability domain. We provide a detailed description of these filters, with illustrative examples, together with new, more general, methods for solving the algebraic equations and with a new algorithm for parameter identification. 1. Introduction There are many problems in science, for example in meteorology and economics, in which the state of a system must be identified from an uncertain equation supplemented by noisy data (see, for instance,[9; 22]). A natural model of this situation consists of an Ito stochastic differential equation (SDE): dx D f .x; t/ dt C g.x; t/ dw; (1) where x D .x1; x2;:::; xm/ is an m-dimensional vector, f is an m-dimensional vector function, g.x; t/ is an m by m matrix, and w is Brownian motion which encapsulates all the uncertainty in the model. In the present paper we assume for simplicity that the matrix g.x; t/ is diagonal. The initial state x.0/ is given and may be random as well. The SDE is supplemented by measurements bn at times tn, n D 0; 1;::: . -
2005 – Building for the Future
2005 – 2006 2005 – Building for the future Working with communities is an important part of ZSL’s effort to involve local people in the welfare of their wildlife Reading this year’s Living Conservation report I am struck by the sheer breadth and vitality of ZSL’s conservation work around the world. It is also extremely gratifying to observe so many successes, ranging from our international animal conservation and scientific research programmes to our breeding of endangered animals and educational projects. Equally rewarding was our growing Zoology at the University of financial strength during 2005. In a year Cambridge. This successful overshadowed by the terrorist attacks collaboration with our Institute of in the capital, ZSL has been able to Zoology has generated numerous demonstrate solid and sustained programmes of research. We are financial growth, with revenue from our delighted that this partnership will website, retailing, catering and business continue for another five years. development operations all up on last Our research projects continued to year. influence policy in some of the world’s In this year’s report we have tried to leading conservation fields, including give greater insight into some of our the trade in bushmeat, the assessment most exciting conservation programmes of globally threatened species, disease – a difficult task given there are so risks to wildlife, and the ecology and many. Fortunately, you can learn more behaviour of our important native about our work on our award-winning* species. website www.zsl.org (*Best Website – At Regent’s Park we opened another Visit London Awards November 2005). two new-look enclosures.