8Th Annual ENDURE Program Booklet 2018
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Happy Holidays
December 2006 VOL. 54, No. 9 S eason’s greetings Happy Holidays Send Address change and returns to the IEEE MONITOR, c/o Membership services, IEEE Service Center, PO Box 1331, Periodical Piscataway, NJ 08855 (ISSN 0164-9205) Time Sensitive Material NY Monitor Vol. 54 No. 9 — December 2006 OFFICERS The Monitor SECTION CHAIR – Kenneth E. Vought VICE CHAIR, OPERATIONS – Stanley Karoly Postmaster: Send Address change and returns to the VICE CHAIR, ACTIVITIES – David M. Weiss IEEE MONITOR, c/o Membership services, IEEE Service TREASURER – Warner W. Johnston Center, PO Box 1331, Piscataway, NJ 08855 - (ISSN SECRETARY – David K. Horn 0164-9205) Please note, the Editor cannot change/remove COMMITTEE CHAIRS addresses. AWARDS CHAIR – Amelie Gong Published monthly, except for June, July and August, by BY-LAW S – William Coyne the New York Section of the Institute of Electrical and CHAPTER ORGANIZATION CHAIR – Bertil C. Lindberg Electronics Engineers, Inc., IEEE Corporate Office, 3 Park EDUCATION – Henry Bertoni Avenue, 17th Floor, New York, NY 10016 -5997 HISTORIAN – Melvin Olken All communications concerning the LONG RANGE PLANNING – William Perlman NY IEEE MONITOR should be addressed to: MEMBERSHIP DEVELOPMENT – Leon Katz NY IEEE MONITOR P.A.C.E. CHAIR – Matt Nissen c/o: Victor Butler, PUBLICATIONS CHAIR – Frank E. Schink 7 Beacon Ct., PUBLICITY & PR – Joern Fellenberg Brooklyn, NY 11229 SPECIAL EVENTS – Ralph Tapino Phone: (718) 968-5199 Fax (216) 927-1235 STUDENT ACTIVITIES – Balvinder Blah E-mail: [email protected] TAPPEN ZEE SUBSECTION – Robert M. Pellegrino Annual subscription: $4.00 per member per year W EBMASTER – Harold Ruchelman (included in annual dues) for each member of the New EDITORIAL STAFF York Section: $10.00 per year for non -IEEE members. -
Huda Y. Zoghbi, MD, Howard Hughes Medical Institute, Jan and Dan Duncan Neurological Research Institute at Texas Children’S Hospital and Baylor College of Medicine
Investigator Spotlight: Huda Y. Zoghbi, MD, Howard Hughes Medical Institute, Jan and Dan Duncan Neurological Research Institute at Texas Children’s Hospital and Baylor College of Medicine It is hard to believe that the 7th World Rett Syndrome Congress has come and gone with great success! Now with summer upon us, IRSF continues to move the spotlight to the committed scientists who have made the World Congress an impressive, high quality meeting with outstanding presentations and discussions. This month we are honored to focus on Dr. Huda Zoghbi who had co-chaired the Basic Research Symposium at the World Congress along with Dr. Gail Mandel. Together, they had produced an exciting lineup of speakers who were encouraged to present new, unpublished data in an effort to foster new ideas that will help chart the course for Rett syndrome research. Dr. Zoghbi is a Howard Hughes Medical Institute (HHMI) Investigator, the Director of the Jan and Dan Duncan Neurological Research Institute at Texas Children’s Hospital, and Professor of the Baylor College of Medicine in Houston, TX. She received her medical degree from Meharry Medical College and completed residency training in pediatrics and neurology at Baylor College of Medicine where she encountered her first Rett syndrome patient in 1983. Dr. Zoghbi was inspired to receive additional research training in the area molecular genetics and upon completion she joined the faculty of Baylor College of Medicine. In 1999, Dr. Zoghbi and collaborators including research fellow Ruthie Amir made a major breakthrough for Rett syndrome. They had discovered that mutations in MECP2, the gene encoding methyl-CpG-binding protein 2, causes Rett syndrome. -
UC San Diego UC San Diego Electronic Theses and Dissertations
UC San Diego UC San Diego Electronic Theses and Dissertations Title Spinocerebellar Ataxia Type 7 is Characterized by Defects in Mitochondrial and Metabolic Function Permalink https://escholarship.org/uc/item/02b7m809 Author Ward, Jacqueline Marie Publication Date 2016 Supplemental Material https://escholarship.org/uc/item/02b7m809#supplemental Peer reviewed|Thesis/dissertation eScholarship.org Powered by the California Digital Library University of California UNIVERSITY OF CALIFORNIA, SAN DIEGO Spinocerebellar Ataxia Type 7 is Characterized by Defects in Mitochondrial and Metabolic Function A dissertation submitted in partial satisfaction of the requirements for the degree Doctor of Philosophy in Biomedical Sciences by Jacqueline Marie Ward Committee in charge: Professor Albert La Spada, Chair Professor Eric Bennett Professor Lawrence Goldstein Professor Alysson Muotri Professor Miles Wilkinson 2016 Copyright Jacqueline Marie Ward, 2016 All rights reserved The Dissertation of Jacqueline Marie Ward is approved, and it is acceptable in quality and form for publication on microfilm and electronically: Chair University of California, San Diego 2016 iii DEDICATION This work is dedicated to my grandfather, Dr. Wayne Ward, the kindest person I’ve ever known. His memory inspires me to be a better person daily. iv TABLE OF CONTENTS SIGNATURE PAGE .......................................................................................... iii DEDICATION .................................................................................................. -
Program Book
PARKINSON’SDISEASE2014 ADVANCING RESEARCH, IMPROVING LIVES PROGRAM MATERIALS Sponsored by: January 6 – 7, 2014 Natcher Conference Center National Institutes of Health Bethesda, MD About our cover: The program cover image is a stylized version of the Parkinson’s Disease Motor-Related Pattern (PDRP), an abnormal pattern of regional brain function observed in MRI studies which shows increased metabolism indicated by red in some brain regions (pallidothalamic, pontine, and motor cortical areas), and decreased metabolism indicated by blue in others (associated lateral premotor and posterior parietal areas). Original image used with permission of David Eidelberg, M.D. For further information see: Hirano et al., Journal of Neuroscience 28 (16): 4201-4209. Welcome Message from Dr. Story C. Landis Welcome to the National Institute of Neurological Disorders and Stroke (NINDS) conference, “Parkinson’s Disease 2014: Advancing Research, Improving Lives.” Remarkable new discoveries and technological advances are rapidly changing the way we study the biological mechanisms of Parkinson’s disease, identify paths to improved treatments, and design effective clinical trials. Elucidating mechanisms and developing and testing effective interventions require a diverse set of approaches and perspectives. The NINDS has organized this conference with the primary goal of seeking consensus on, and prioritizing, research recommendations spanning clinical, translational, and basic Parkinson’s disease research that we support. We have assembled a stellar and dedicated group of session chairs and panelists who have worked collaboratively to identify emerging research opportunities in Parkinson’s research. While we have divided our working groups into three main research areas, we expect each will inform the others over the course of the next two days, and we look forward to both complementary and unique perspectives. -
Huda Zoghbi: Taking Genetic Inquiry to the Next Level
Spectrum | Autism Research News https://www.spectrumnews.org NEWS, PROFILES Huda Zoghbi: Taking genetic inquiry to the next level BY RACHEL ZAMZOW 25 JUNE 2021 Listen to this story: Most mornings, Huda Zoghbi, 67, climbs a glass-encased, curling staircase to reach her lab on the top and 13th floor of the Jan and Dan Duncan Neurological Research Institute in Houston, Texas. The twisting glass tower, which she designed with a team of architects, echoes the double helix of DNA — a structure that has been central to her career-long quest to uncover genes underlying neurological conditions. As the institute’s director — and as a scientist— she is known for going beyond the standard job description. Genetics researchers often cast a wide net and sequence thousands of genes at a time. But in her prolific career, Zoghbi has focused on a handful of genes, methodically building up an understanding of their function one careful step at a time. Thanks to that approach, Zoghbi has made a number of landmark discoveries, including identifying the genetic roots of Rett syndrome, an autism-related condition that primarily affects girls, as well as the genetic mutations that spur spinocerebellar ataxia, a degenerative motor condition. She has authored more than 350 journal articles. Her accomplishments have earned her almost every major biology and neuroscience research award, including the prestigious Breakthrough Prize in 2017 and the Brain Prize in 2020. “She’s clearly the international leader in the field,” said the late Stephen Warren, professor of human genetics at Emory University in Atlanta, Georgia. Zoghbi never set out to lead a large research center, she says — her heart is in the lab. -
2016 Joint Meeting Program
April 15 – 17, 2016 Fairmont Chicago Millennium Park • Chicago, Illinois The AAP/ASCI/APSA conference is jointly provided by Boston University School of Medicine and AAP/ASCI/APSA. Meeting Program and Abstracts www.jointmeeting.org www.jointmeeting.org Special Events at the 2016 AAP/ASCI/APSA Joint Meeting Friday, April 15 Saturday, April 16 ASCI President’s Reception ASCI Food and Science Evening 6:15 – 7:15 p.m. 6:30 – 9:00 p.m. Gold Room The Mid-America Club, Aon Center ASCI Dinner & New Member AAP Member Banquet Induction Ceremony (Ticketed guests only) (Ticketed guests only) 7:00 – 10:00 p.m. 7:30 – 9:45 p.m. Imperial Ballroom, Level B2 Rouge, Lobby Level How to Solve a Scientific Puzzle: Speaker: Clara D. Bloomfield, MD Clues from Stockholm and Broadway The Ohio State University Comprehensive Cancer Center Speaker: Joe Goldstein, MD APSA Welcome Reception & University of Texas Southwestern Medical Center at Dallas Presidential Address APSA Dinner (Ticketed guests only) 9:00 p.m. – Midnight Signature Room, 360 Chicago, 7:30 – 9:00 p.m. John Hancock Center (off-site) Rouge, Lobby Level Speaker: Daniel DelloStritto, APSA President Finding One’s Scientific Niche: Musings from a Clinical Neuroscientist Speaker: Helen Mayberg, MD, Emory University Dessert Reception (open to all attendees) 10:00 p.m. – Midnight Imperial Foyer, Level B2 Sunday, April 17 APSA Future of Medicine and www.jointmeeting.org Residency Luncheon Noon – 2:00 p.m. Rouge, Lobby Level 2 www.jointmeeting.org Program Contents General Program Information 4 Continuing Medical Education Information 5 Faculty and Speaker Disclosures 7 Scientific Program Schedule 9 Speaker Biographies 16 Call for Nominations: 2017 Harrington Prize for Innovation in Medicine 26 AAP/ASCI/APSA Joint Meeting Faculty 27 Award Recipients 29 Call for Nominations: 2017 Harrington Scholar-Innovator Award 31 Call for Nominations: George M. -
Setting the Occasion for Incentive Motivation: Implications for Addiction
bioRxiv preprint doi: https://doi.org/10.1101/428409; this version posted September 26, 2018. The copyright holder for this preprint (which was not certified by peer review) is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under aCC-BY-NC-ND 4.0 International license. Fraser & Janak, 09.26.2018 – preprint copy - BioRxiv Setting the Occasion for Incentive Motivation: Implications for Addiction Kurt M. Frasera & Patricia H. Janaka,b,c a Department of Psychological & Brain Sciences, Krieger School of Arts and Sciences, Johns Hopkins University, Baltimore, MD 21218 b The Solomon H. Snyder Department of Neuroscience, Johns Hopkins School of Medicine, Baltimore, MD 21205 c Kavli Neuroscience Discovery Institute, Johns Hopkins School of Medicine, Baltimore, MD 21205 Correspondence: To either Kurt M. Fraser ([email protected]) or Patricia H. Janak ([email protected]) as above Abstract The context in which reward-paired cues are encountered sets the occasion for appropriate reward-seeking but may also spur inappropriate behaviors such as the renewal of drug-seeking. The psychological processes underlying occasion setting remain unclear as contexts are diffuse and difficult to isolate from other stimuli. To overcome this, we modeled a context as a phasic and discrete event – an occasion setter – which allowed for control over its presentation and influence on cue-driven reward-seeking. This allowed us to directly assess how occasion setters, like contexts, regulate the predictive and motivational significance of Pavlovian cues. Male rats (n=50) were trained in a Pavlovian paradigm where the presentation of an ambiguous conditioned stimulus was reinforced only if preceded by an occasion setting cue. -
Mu-Opioid Receptor Activation in the Medial Shell of Nucleus Accumbens Promotes Alcohol Consumption, Self-Administration and Cue-Induced Reinstatement
UCSF UC San Francisco Previously Published Works Title Ventral Pallidum Neurons Encode Incentive Value and Promote Cue-Elicited Instrumental Actions. Permalink https://escholarship.org/uc/item/6v2169m1 Journal Neuron, 90(6) ISSN 0896-6273 Authors Richard, Jocelyn M Ambroggi, Frederic Janak, Patricia H et al. Publication Date 2016-06-01 DOI 10.1016/j.neuron.2016.04.037 Peer reviewed eScholarship.org Powered by the California Digital Library University of California Neuropharmacology 108 (2016) 14e23 Contents lists available at ScienceDirect Neuropharmacology journal homepage: www.elsevier.com/locate/neuropharm Mu-opioid receptor activation in the medial shell of nucleus accumbens promotes alcohol consumption, self-administration and cue-induced reinstatement * Jocelyn M. Richard , Howard L. Fields Department of Neurology, The Wheeler Center for the Neurobiology of Addiction, Alcoholism and Addiction Research Group, University of California, San Francisco, CA, USA article info abstract Article history: Endogenous opioid signaling in ventral cortico-striatal-pallidal circuitry is implicated in elevated alcohol Received 15 November 2015 consumption and relapse to alcohol seeking. Mu-opioid receptor activation in the medial shell of the Received in revised form nucleus accumbens (NAc), a region implicated in multiple aspects of reward processing, elevates alcohol 6 April 2016 consumption while NAc opioid antagonists reduce it. However, the precise nature of the increases in Accepted 8 April 2016 alcohol consumption, and the effects of mu-opioid agonists on alcohol seeking and relapse are not clear. Available online 14 April 2016 Here, we tested the effects of the mu-opioid agonist [D-Ala2, N-MePhe4, Gly-ol]-enkephalin (DAMGO) in rat NAc shell on lick microstructure in a free-drinking test, alcohol seeking during operant self- Keywords: Alcohol administration, extinction learning and expression, and cue-reinforced reinstatement of alcohol Nucleus accumbens seeking. -
Program in Neuroscience
Harvard University Program in Neuroscience Faculty Directory 2016—2017 April 1, 2017 Disclaimer Please note that in the following descripons of faculty members, only students from the Program in Neuroscience are listed. You cannot assume that if no students are listed, it is a small or inacve lab. Many faculty members are very acve in other programs such as Biological and Biomedical Sciences, Molecular and Cellular Biology, etc. If you find you are interested in the descripon of a lab’s research, you should contact the faculty member (or go to the lab’s website) to find out how big the lab is, how many graduate students are doing there thesis work there, etc. Program in Neuroscience Faculty Albers, Mark (MGH-East)) Dong, Min (BCH) Lampson, Lois (BWH) Sabatini, Bernardo (HMS/Neurobio) Andermann, Mark (BIDMC) Drugowitsch, Jan (HMS/Neurobio) LaVoie, Matthew (BWH) Sahay, Amar (MGH) Anderson, Matthew (BIDMC) Dulac, Catherine (Harvard/MCB) Lee, Wei-Chung (BCH/Neurobio) Sahin, Mustafa (BCH/Neurobio) Anthony, Todd (BCH/Neurobio) Dymecki, Susan(HMS/Genetics) Lehtinen, Maria (BCH/Pathology) Samuel, Aravi (Harvard/ Physics) Arlotta, Paola (Harvard/SCRB) Engert, Florian (Harvard/MCB) Liberles, Steve (HMS/Cell Biology) Sanes, Joshua (Harvard/MCB) Assad, John (HMS/Neurobio) Engle, Elizabeth(BCH/Neurobio) Lichtman, Jeff (Harvard/MCB) Saper, Clifford (BIDMC) Bacskai, Brian (MGH/East) Eskandar, Emad (MGH) Lipton, Jonathan (BCH/Neurobio) Scammell, Thomas (BIDMC) Bean, Bruce (HMS/Neurobio) Fagiolini, Michela (BCH/Neurobio) Livingstone, Marge (HMS/Neurobio) -
Kurt Michael Fraser, Phd 142 Weill Hall Cell: #3200, Berkeley, CA 94720 Email: [email protected]
Updated May 2021 Kurt Michael Fraser, PhD 142 Weill Hall Cell: #3200, Berkeley, CA 94720 Email: [email protected] CURRENT POSITION Postdoctoral Scholar May 2021-Present University of California - Berkeley Supervisor: Stephan Lammel, PhD EDUCATION Johns Hopkins University, Baltimore, MD 2021 PhD in Psychological & Brain Sciences (Biopsychology) Supervisor: Patricia H. Janak, PhD Dissertation Topic: Setting the Occasion for Reward-seeking in Brain and Behavior Johns Hopkins University, Baltimore, MD 2017 MA in Psychological & Brain Sciences (Biopsychology) Supervisor: Patricia H. Janak, PhD Master’s Thesis: Dorsal and Ventral Striatal Systems in the Attribution of Incentive Salience to Reward-Paired Cues University of Michigan, Ann Arbor, MI 2015 BS in Neuroscience with High Honors & Distinction Supervisor: Shelly B. Flagel, PhD Thesis: Contributions of Dopamine D2 and D3 Receptors to Pavlovian Conditioned Approach RESEARCH INTERESTS Neurobiological mechanisms of cue-triggered motivated behavior: • How are reward learning and conditioned motivation separable in both behavior and neurobiology? • What neural circuits underlie the attribution of conditioned motivation to reward-paired cues? • How is ambiguity about the motivational value of conditioned cues in the environment resolved to produce reward-seeking? • What is the content of learning? • How do neural circuits supporting adaptive reward-seeking go awry in mental health disorders such as alcohol abuse and addiction? RESEARCH SUPPORT AND FELLOWSHIPS NIH BRAIN Initiative Fellows NRSA Postdoctoral Fellowship (F32 MH127792) 2021-2024 Using large-scale electrophysiology to study the role of midbrain dopamine neurons underlying motivated behavior NIH NRSA Predoctoral Fellowship (F31 DA046136) 2019-2021 The role of the basolateral amygdala in occasion setting Kurt M. Fraser Curriculum Vitae Updated May 2021 MANUSCRIPTS IN PREPARATION Fraser KM, Collins V, Pat F, Saunders BT, & Janak PH. -
Single-Cell Transcriptomics of the Developing Lateral PNAS PLUS Geniculate Nucleus Reveals Insights Into Circuit Assembly and Refinement
Single-cell transcriptomics of the developing lateral PNAS PLUS geniculate nucleus reveals insights into circuit assembly and refinement Brian T. Kalisha,b,1, Lucas Cheadlea,1, Sinisa Hrvatina, M. Aurel Nagya,c, Samuel Riveraa, Megan Crowd, Jesse Gillisd, Rory Kirchnere, and Michael E. Greenberga,2 aDepartment of Neurobiology, Harvard Medical School, Boston, MA 02115; bDivision of Newborn Medicine, Department of Medicine, Boston Children’s Hospital, Boston, MA 02115; cProgram in Neuroscience, Harvard Medical School, Boston, MA 02115; dCold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724; and eBioinformatics Core, Department of Biostatistics, Harvard T.H. Chan School of Public Health, Boston, MA 02115 Contributed by Michael E. Greenberg, December 18, 2017 (sent for review October 23, 2017; reviewed by Matthew B. Dalva and Sacha B. Nelson) Coordinated changes in gene expression underlie the early pattern- the cleft to organize synaptic architecture and composition (15– ing and cell-type specification of the central nervous system. 17). The process of synaptogenesis is accompanied by myelination, However, much less is known about how such changes contribute which accrues as the circuit matures, ensuring the efficiency of to later stages of circuit assembly and refinement. In this study, we action potential propagation within both local and long-range employ single-cell RNA sequencing to develop a detailed, whole- circuits (18, 19). Finally, synapses are strengthened or eliminated transcriptome resource of gene expression across four time points in based upon a process of activity-dependent synaptic refinement the developing dorsal lateral geniculate nucleus (LGN), a visual that is in part mediated through the tagging of synapses with structure in the brain that undergoes a well-characterized program complement proteins such as C1q and C3 (20–22). -
Science at Columbia — Brilliant Blue 2 Brilliant Science Is…
Added 3/4 pt Stroke Science at Columbia — Brilliant Blue 2 Brilliant Science is… Studying Cutting-Edge Interdisciplinary Fields Page 8 Working with Engaging in Faculty at the Forefront Research of Discovery from Day One Page 14 Page 20 Columbia Blue Earning Joining a Core Distinction Community of in the Trailblazers World of Science Page 12 Page 26 Living in New York City — A Premier Science City Page 28 …the imagination, creativity, and innovation of Columbia students. 3 “ Research has been a defin ing aspect for me as a science major here at Col umbia. A year ago I could not have imagined that I would be flown out to Texas to be acknowled ged for the research I have been conducting. It is because of the opportunities I have been offered by Columbia and my professors that m y career as a successful scientist is already begin ning to take shape.” amanda olivo Biochemistry 4 “ Research has been a defin ing aspect for me as a science major here at Col umbia. A year ago I could not have imagined that I would be flown out to Texas to be acknowled ged for the research I have been conducting. It is because of the opportunities I have been offered by Columbia and my professors that m y career as a successful scientist is already begin ning to take shape.” amanda olivo Biochemistry 5 Join a rich tradition of discovery and innovation Among the many that has changed history and human understanding research opportunities available to Columbia of the world.