10uM 0.1uM Torin1 IC50 Kinase Reference Description Labeling SiteSequence Torin1 1uM Torin1 Torin1 (mM) 10uM Torin2 1uM Torin2 ABL,ARG UniRef100_P00519Proto-oncogeneLys1 tyrosine-proteinYSLTVAVkTLKEDTMEVEEFLK kinase ABL125.8 [Homo sapiens17.2 (Human)]25.6 >10 -5.5 -5.6 ACK UniRef100_Q07912Activated CDC42Lys1 kinase 1 TVSVAVkCLKPDVLSQPEAMDDFIR[Homo sapiens (Human)]6.5 -4.0 -19.3 >10 9.2 -9.1 AKT2,AKT3 UniRef100_P31751RAC-beta serine/threonine-proteinATP Loop GTFGkVILVR kinase [Homo38.8 sapiens30.9 (Human)]29.7 >10 -36.2 -25.0 AMPKa1 UniRef100_Q131315'-AMP-activatedATP protein Loop IGHYILGDTLGVGTFGkVKkinase catalytic subunit-8.9 alpha-1-13.7 [Homo sapiens-22.3 (Human)]>10 -15.9 -8.1 AMPKa1,AMPKa2UniRef100_Q131315'-AMP-activatedLys1 protein VAVkILNRkinase catalytic subunit-16.9 alpha-1-32.4 [Homo sapiens-21.4 (Human)]>10 19.9 2.1 AMPKa1,AMPKa2UniRef100_Q131315'-AMP-activatedLys2 protein DLkPENVLLDAHMNAKkinase catalytic subunit-2.6 alpha-1-7.6 [Homo sapiens5.4 (Human)]>10 25.6 5.6 ARAF UniRef100_P10398A-Raf proto-oncogeneLys2 serine/threonine-proteinDLkSNNIFLHEGLTVK27.2 kinase23.6 [Homo sapiens8.3 (Human)]>10 23.4 5.3 ATM UniRef100_Q13315Serine-proteinATP kinase ATMQLVkGRDDLRQDAVMQQVFQMCNTLLQR [Homo sapiens (Human)]>95 79.1 42.8 0.15 >95 >95 ATR UniRef100_Q13535Serine/threonine-proteinATP FYIMMCkPKkinase ATR [Homo98.7 sapiens (Human)]95.5 70.3 0.039 99.5 99.5 ATR UniRef100_Q13535Serine/threonine-proteinProtein Kinase kAGHHQTAYNALLNAGESRkinase Domain ATR [Homo-0.9 sapiens (Human)]0.0 2.0 >10 -12.2 -7.0 AurA UniRef100_O14965Serine/threonine-proteinLys2 VIHRDIkPENLLLGSAGELKkinase 6 [Homo sapiens14.6 (Human)]-21.3 -30.2 >10 1.0 -3.0 AurA UniRef100_O14965Serine/threonine-proteinLys1 FILALkVLFKkinase 6 [Homo sapiens1.3 (Human)]5.3 -4.5 >10 21.1 5.9 AurA UniRef100_O14965Serine/threonine-proteinLys2 DIkPENLLLGSAGELKkinase 6 [Homo sapiens0.1 (Human)]5.4 1.6 >10 25.3 3.5 AurA,AurB,AurCUniRef100_Q9UQB9Serine/threonine-proteinATP Loop GkFGNVYLARkinase 13 [Homo -7.5sapiens (Human)]-7.2 3.6 >10 22.6 4.6 AurB UniRef100_Q96GD4Serine/threonine-proteinLys1 SHFIVALkVLFKkinase 12 [Homo sapiens3.4 (Human)]5.3 0.2 >10 23.1 13.4 BARK1 UniRef100_P25098Beta-adrenergicLys2 receptor DLkPANILLDEHGHVRkinase 1 n=1 Tax=Homo0.8 sapiens-21.0 RepID=ARBK1_HUMAN-5.0 >10 2.3 -0.3 BARK1,BARK2UniRef100_P25098Beta-adrenergicActivation receptor Loop kKPHASVGTHGYMAPEVLQKkinase 1 n=1 Tax=Homo-19.5 sapiens-31.8 RepID=ARBK1_HUMAN-13.4 >10 -13.2 -32.7 BLK UniRef100_P51451Tyrosine-proteinLys1 kinase BLKVAIkTLKEGTMSPEAFLGEANVMK n=2 Tax=Homo0.1 sapiens RepID=BLK_HUMAN51.6 4.4 >10 17.4 -1.4 BLK UniRef100_P51451Tyrosine-proteinActivation kinase BLK LoopIIDSEYTAQEGAkFPIK n=2 Tax=Homo-0.5 sapiens RepID=BLK_HUMAN27.5 26.9 >10 19.8 -4.5 BRAF UniRef100_P15056B-Raf proto-oncogeneLys2 serine/threonine-proteinDLkSNNIFLHEDLTVK3.2 kinase 4.9[Homo sapiens-15.1 (Human)]>10 -16.9 15.2 BTK UniRef100_Q06187Tyrosine-proteinActivation kinase BTK LoopYVLDDEYTSSVGSkFPVR [Homo sapiens]10.0 5.2 8.8 >10 35.1 -4.5 CaMK1d UniRef100_Q8IU85Calcium/calmodulin-dependentLys1 LFAVkCIPK protein kinase-1.6 type 1D-0.7 [Homo sapiens-1.7 (Human)]>10 10.6 -5.0 CaMK2a,CaMK2b,CaMK2d,CaMK2gUniRef100_Q9UQM7Calcium/calmodulin-dependentLys2 DLkPENLLLASK protein kinase-2.5 type II alpha-35.3 chain [Homo7.7 sapiens>10 (Human)] 36.1 5.5 CaMK2d UniRef100_Q13557Calcium/calmodulin-dependentLys1 IPTGQEYAAkIINTK protein kinase-9.1 type II delta12.1 chain n=214.0 Tax=Euarchontoglires>10 30.4RepID=KCC2D_HUMAN-10.6 CaMK2g UniRef100_Q13555Calcium/calmodulin-dependentLys1 TSTQEYAAkIINTK protein kinase3.0 type II gamma-12.2 chain-14.4 [Homo sapiens>10 (Human)]27.6 -1.2 CaMK2g UniRef100_Q13555Calcium/calmodulin-dependentLys1 KTSTQEYAAkIINTK protein kinase-0.7 type II gamma-22.1 chain14.1 [Homo sapiens>10 (Human)]27.8 -29.8 CaMK4 UniRef100_Q16566Calcium/calmodulin-dependentLys2 DLkPENLLYATPAPDAPLKIADFGLSK protein kinase-2.7 type IV -11.2[Homo sapiens-11.5 (Human)]>10 -5.6 -28.2 CaMK4 UniRef100_Q16566Calcium/calmodulin-dependentLys2 DLkPENLLYATPAPDAPLK protein kinase-7.7 type IV -20.7[Homo sapiens-9.6 (Human)]>10 7.5 3.1 CaMKK2 UniRef100_Q96RR4Calcium/calmodulin-dependentLys1 LAYNENDNTYYAMkVLSK protein kinase-3.1 kinase 2-19.6 [Homo sapiens-29.3 (Human)]>10 -11.9 -45.0 CASK UniRef100_O14936Peripheral plasmaLys1 membraneETGQQFAVkIVDVAK protein CASK-2.9 n=2 Tax=Catarrhini2.5 RepID=CSKP_HUMAN-5.8 >10 42.0 12.2 CDC2 UniRef100_P06493Cell division controlLys2 proteinDLkPQNLLIDDKGTIK 2 homolog [Homo6.6 sapiens 21.0(Human)] 12.6 >10 5.7 -15.3 CDK10 UniRef100_Q15131Cell division proteinLys2 kinaseDLkVSNLLMTDK 10 [Homo sapiens-10.3 (Human)]-1.4 2.0 >10 -0.1 -10.1 CDK11,CDK8UniRef100_P49336Cell division proteinLys2 kinaseDLkPANILVMGEGPER 8 [Homo sapiens82.5 (Human)] 39.8 6.8 1.52 50.9 3.9 CDK2 UniRef100_P24941Cell division proteinLys1 kinaseNKLTGEVVALkK 2 [Homo sapiens6.9 (Human)]-10.5 -10.1 >10 -2.4 -1.0 CDK2 UniRef100_P24941Cell division proteinLys2 kinaseDLkPQNLLINTEGAIK 2 [Homo sapiens-9.6 (Human)] -4.6 2.7 >10 14.5 -9.0 CDK5 UniRef100_Q00535Cell division proteinLys2 kinaseDLkPQNLLINR 5 [Homo sapiens-6.8 (Human)]-10.0 -9.1 >10 -4.5 -12.0 CDK5 UniRef100_Q00535Cell division proteinLys1 kinaseNRETHEIVALkR 5 [Homo sapiens-15.0 (Human)] 5.5 4.9 >10 -2.2 5.8 CDK6 UniRef100_Q00534Cell division proteinLys2 kinaseVVHRDLkPQNILVTSSGQIK 6 [Homo sapiens-29.3 (Human)]-36.0 -37.5 >10 -1.9 -8.5 CDK6 UniRef100_Q00534Cell division proteinLys2 kinaseDLkPQNILVTSSGQIK 6 [Homo sapiens13.7 (Human)] 9.3 -0.6 >10 5.3 -10.6 CDK7 UniRef100_P50613Cell division proteinLys2 kinaseDLkPNNLLLDENGVLK 7 [Homo sapiens-4.6 (Human)] -3.8 6.1 >10 33.3 -6.3 CDK9 UniRef100_P50750Cell division proteinLys2 kinaseDMkAANVLITR 9 [Homo sapiens-14.6 (Human)] -7.1 -7.3 >10 -0.8 -14.2 CHED UniRef100_Q14004Cell division cycleLys2 2-like proteinDIkCSNILLNNR kinase 5 [Homo-5.3 sapiens-71.3 (Human)] -6.8 >10 -23.3 18.2 CHK1 UniRef100_O14757Serine/threonine-proteinOther LSkGDGLEFKkinase Chk1 [Homo-12.7 sapiens (Human)]6.3 1.9 >10 1.1 6.8 CHK2 UniRef100_O96017Serine/threonine-proteinLys2 DLkPENVLLSSQEEDCLIKITDFGHSKkinase Chk2 [Homo-7.9 sapiens (Human)]-17.2 -27.3 >10 -6.5 25.0 CHK2 UniRef100_O96017Serine/threonine-proteinLys1 VAIkIISKkinase Chk2 [Homo-19.5 sapiens (Human)]-7.7 1.3 >10 -6.1 -7.2 CHK2 UniRef100_O96017Serine/threonine-proteinLys2 DLkPENVLLSSQEEDCLIKkinase Chk2 [Homo2.3 sapiens (Human)]28.0 1.8 >10 -2.2 -3.2 CK1a UniRef100_P48729Casein kinase ILys2 isoform alphaDIkPDNFLMGIGR [Homo sapiens-12.4 (Human)] -6.6 -7.7 >10 -3.6 0.3 CK1d,CK1e UniRef100_P48730Casein kinase ILys2 isoform deltaDVkPDNFLMGLGKK [Homo sapiens8.2 (Human)] -4.5 3.7 >10 11.7 -8.3 CLK3 UniRef100_P49761Dual specificityATP protein Loop kinaseYEIVGNLGEGTFGkVVECLDHAR CLK3 n=1 Tax=Homo6.0 sapiens-3.0 RepID=CLK3_HUMAN-6.1 >10 32.9 10.4 CSK UniRef100_P41240Tyrosine-proteinActivation kinase CSK LoopVSDFGLTkEASSTQDTGKLPVK [Homo sapiens-0.2 (Human)] -4.3 -4.1 >10 0.1 -0.6 CSK UniRef100_P41240Tyrosine-proteinActivation kinase CSK LoopEASSTQDTGKLPVkWTAPEALR [Homo sapiens-10.5 (Human)] -3.7 -2.6 >10 3.0 8.4 DGKA UniRef100_P23743Diacylglycerol kinaseATP alphaVLWkFQYILNPR [Homo sapiens 10.0(Human)] -10.9 -12.1 >10 -59.9 -11.7 DGKA UniRef100_P23743Diacylglycerol kinaseATP alphaIDPVPNTHPLLVFVNPkSGGK [Homo sapiens 37.5(Human)] 5.1 12.6 >10 -1.5 -9.2 DGKH UniRef100_Q86XP1Diacylglycerol kinaseATP eta2ATFSFCVSPLLVFVNSkSGDNQGVK [Homo sapiens (Human)]-21.6 3.6 3.9 >10 18.0 29.0 DMPK1 UniRef100_Q09013Myotonin-proteinLys1 kinase [HomoMKQTGQVYAmKIMNK sapiens (Human)]15.0 22.6 5.6 >10 7.8 9.7 DMPK1 UniRef100_Q09013Myotonin-proteinLys2 kinase [HomoDIkPDNILLDR sapiens (Human)]-5.4 22.9 20.0 >10 7.9 -9.6 DNAPK UniRef100_P78527DNA-dependentATP protein kinaseEHPFLVkGGEDLR catalytic subunit>98 [Homo96.6 sapiens (Human)]83.1 0.018 99.6 99.6 DNAPK UniRef100_P78527DNA-dependentATP protein kinaseGHDEREHPFLVkGGEDLR catalytic subunit98.6 [Homo93.4 sapiens (Human)]67.7 0.044 98.9 98.8 DNAPK UniRef100_P78527DNA-dependentATP protein kinasekGGSWIQEINVAEKNWYPR catalytic subunit98.8 [Homo94.9 sapiens (Human)]64.0 0.052 98.5 97.2 eEF2K UniRef100_O00418Elongation factorProtein 2 kinase KinaseYIkYNSNSGFVR [Homo Domain sapiens (Human)]-3.1 3.2 -0.7 >10 2.9 -1.3 Erk1 UniRef100_P27361Mitogen-activatedLys2 proteinDLkPSNLLINTTCDLK kinase 3 [Homo -3.6sapiens (Human)]-14.7 -26.4 >10 2.2 -10.7 Erk5 UniRef100_Q13164Mitogen-activatedLys2 proteinDLkPSNLLVNENCELK kinase 7 n=2 Tax=Homo13.4 sapiens14.6 RepID=MK07_HUMAN17.1 >10 13.3 30.8 FAK UniRef100_Q05397Focal adhesionLys1 kinase 1 [HomoCIGEGQFGDVHQGIYMSPENPALAVAIkTCK sapiens (Human)]13.9 -27.7 -16.5 >10 -15.8 -9.0 FER UniRef100_P16591Proto-oncogeneLys1 tyrosine-proteinTSVAVkTCKEDLPQELK kinase FER0.6 n=2 Tax=Homo-36.2 sapiens-10.1 RepID=FER_HUMAN>10 -3.3 0.6 FER UniRef100_P16591Proto-oncogeneActivation tyrosine-protein LoopQEDGGVYSSSGLkQIPIKWTAPEALNYGR kinase FER-12.0 n=2 Tax=Homo-26.1 sapiens-9.4 RepID=FER_HUMAN>10 10.7 20.4 FGR UniRef100_P09769Proto-oncogeneActivation tyrosine-protein LoopLIKDDEYNPCQGSkFPIK kinase FGR-0.8 [Homo sapiens4.4 (Human)]1.5 >10 7.2 6.6 FRAP UniRef100_P42345FKBP12-rapamycinATP complex-associatedIQSIAPSLQVITSkQRPR protein99.1 [Homo 98.8sapiens (Human)]98.3 <0.01 98.5 98.7 FYN UniRef100_P06241Proto-oncogeneLys1 tyrosine-proteinVAIkTLKPGTMSPESFLEEAQIMK kinase Fyn7.0 n=2 Tax=Homo-8.0 sapiens-2.9 RepID=FYN_HUMAN>10 -7.7 -13.8 FYN,SRC,YESUniRef100_P06241Proto-oncogeneActivation tyrosine-protein LoopQGAkFPIKWTAPEAALYGR kinase Fyn-27.6 n=2 Tax=Homo-52.7 sapiens-26.0 RepID=FYN_HUMAN>10 -16.0 -21.4 GCK UniRef100_Q12851Mitogen-activatedLys2 proteinIHRDIkGANLLLTLQGDVK kinase kinase kinase15.5 kinase -48.72 n=1 Tax=Homo-48.8 sapiens>10 RepID=M4K2_HUMAN-11.3 -27.8 GCK UniRef100_Q12851Mitogen-activatedLys1 proteinDTVTSELAAVkIVK kinase kinase kinase38.4 kinase 24.9 n=1 Tax=Homo-13.4 sapiens>10 RepID=M4K2_HUMAN8.2 -5.7 GCK UniRef100_Q12851Mitogen-activatedLys2 proteinDIkGANLLLTLQGDVK kinase kinase kinase40.6 kinase 28.3 n=1 Tax=Homo0.2 sapiens>10 RepID=M4K2_HUMAN19.8 -4.4 GCN2 domain2UniRef100_Q9P2K8Eukaryotic translationLys1 initiationVQNKLDGCCYAVkR factor 2-alpha4.1 kinase 4 5.3[Homo sapiens10.1 (Human)]>10 -0.4 -16.1 GSK3A UniRef100_P49840Glycogen synthaseLys2 kinase-3DIkPQNLLVDPDTAVLK alpha [Homo sapiens0.9 (Human)]-3.0 0.0 >10 61.6 3.4 GSK3B UniRef100_P49841Glycogen synthaseLys2 kinase-3DIkPQNLLLDPDTAVLK beta n=2 Tax=Homo-0.4 sapiens-10.0 RepID=GSK3B_HUMAN-11.9 >10 29.0 -0.7 HPK1 UniRef100_Q92918Mitogen-activatedLys1 proteinVSGDLVALkMVK kinase kinase kinase24.1 kinase 1-6.4 [Homo sapiens-21.3 (Human)]>10 -3.7 4.1 HPK1 UniRef100_Q92918Mitogen-activatedLys1 proteinDKVSGDLVALkMVK kinase kinase kinase16.6 kinase 1-5.1 [Homo sapiens-2.6 (Human)]>10 -1.9 -7.1 HPK1 UniRef100_Q92918Mitogen-activatedLys2 proteinDIkGANILINDAGEVR kinase kinase kinase23.2 kinase 14.5 [Homo sapiens4.0 (Human)]>10 15.2 3.0 IKKa UniRef100_O15111Inhibitor of nuclearLys2 factorIIHRDLkPENIVLQDVGGK kappa-B kinase alpha-16.4 subunit-36.3 [Homo sapiens-22.2 (Human)]>10 -2.6 -30.3 IKKa UniRef100_O15111Inhibitor of nuclearLys2 factorDLkPENIVLQDVGGK kappa-B kinase alpha-8.8 subunit-2.4 [Homo sapiens1.0 (Human)]>10 0.0 5.4 IKKb UniRef100_O14920Inhibitor of nuclearLys2 factorDLkPENIVLQQGEQR kappa B kinase beta-8.4 subunit -7.8[Homo sapiens-4.3 (Human)]>10 2.4 -13.0 IKKe UniRef100_Q14164Inhibitor of nuclearLys1 factorSGELVAVkVFNTTSYLRPR kappa-B kinase epsilon5.7 subunit-1.2 [Homo sapiens5.6 (Human)]>10 6.3 -4.9 IKKe UniRef100_Q14164Inhibitor of nuclearActivation factor LoopELDDDEkFVSVYGTEEYLHPDMYER kappa-B kinase epsilon8.5 subunit-22.1 [Homo sapiens7.8 (Human)]>10 9.8 -1.8 IKKe,TBK1 UniRef100_Q14164Inhibitor of nuclearLys2 factorDIkPGNIMR kappa-B kinase epsilon-14.0 subunit-36.5 [Homo sapiens-21.2 (Human)]>10 -8.0 -13.3 ILK UniRef100_Q13418Integrin-linkedProtein protein Kinase kinaseISMADVkFSFQCPGR Domain 1 [Homo sapiens-13.4 (Human)]-1.3 -6.6 >10 -13.6 -24.4 ILK UniRef100_Q13418Integrin-linkedLys1 protein kinaseWQGNDIVVkVLK 1 [Homo sapiens-19.5 (Human)]-1.2 2.1 >10 1.4 -12.8 INSR UniRef100_P06213Insulin receptorLys1 precursorVAVkTVNESASLR (EC 2.7.1.112) (IR)8.0 (CD220 antigen)-3.6 [Contains:9.4 Insulin >10receptor alpha24.5 subunit; Insulin30.3 receptor beta subunit] [Homo sapiens (Human)] IRAK4 UniRef100_Q9NWZ3Interleukin-1 receptor-associatedLys1 GYVNNTTVAVkK kinase 4 [Homo2.9 sapiens-5.1 (Human)]-8.7 >10 17.1 -9.7 IRAK4 UniRef100_Q9NWZ3Interleukin-1 receptor-associatedLys2 DIkSANILLDEAFTAK kinase 4 [Homo-0.3 sapiens-6.4 (Human)]-8.5 >10 18.8 -1.7 IRE1 UniRef100_O75460EndoribonucleaseLys2 n=1 Tax=HomoDLkPHNILISMPNAHGK sapiens RepID=ERN1_HUMAN7.3 -0.1 3.9 >10 -12.4 -19.4 ITPK1 UniRef100_Q13572Inositol-tetrakisphosphateATP ESIFFNSHNVSkPESSSVLTELDKIEGVFERPSDEVIR 1-kinase [Homo sapiens2.8 (Human)]4.0 23.2 >10 -13.3 10.4 JAK1 UniRef100_P23458Tyrosine-proteinOther kinase JAK1QLASALSYLEDKDLVHGNVCTkNLLLAR n=1 Tax=Homo5.9 sapiens RepID=JAK1_HUMAN6.7 -8.3 >10 88.3 50.0 JAK1 domain2UniRef100_P23458Tyrosine-proteinLys1 kinase JAK1YDPEGDNTGEQVAVkSLKPESGGNHIADLKK n=1 Tax=Homo3.0 sapiens RepID=JAK1_HUMAN-7.4 -7.3 >10 -26.9 -9.4 JAK1 domain2UniRef100_P23458Tyrosine-proteinActivation kinase JAK1 LoopIGDFGLTkAIETDKEYYTVK n=1 Tax=Homo10.2 sapiens RepID=JAK1_HUMAN9.1 6.0 >10 24.0 7.7 JAK1 domain2UniRef100_P23458Tyrosine-proteinActivation kinase JAK1 LoopIGDFGLTkAIETDKEYYTVKDDR n=1 Tax=Homo26.1 sapiens RepID=JAK1_HUMAN3.7 18.5 >10 27.0 2.4 JAK3 domain2UniRef100_P52333Tyrosine-proteinLys1 kinase JAK3YDPLGDNTGALVAVkQLQHSGPDQQR [Homo sapiens3.0 (Human)]13.2 6.3 >10 -7.9 -5.4 JNK1,JNK2,JNK3UniRef100_P45983Mitogen-activatedLys2 proteinDLkPSNIVVK kinase 8 [Homo 23.6sapiens (Human)]-2.4 0.0 >10 51.7 9.2 KHS1 UniRef100_Q9Y4K4Mitogen-activatedLys1 proteinNVHTGELAAVkIIK kinase kinase kinase16.7 kinase -19.85 [Homo sapiens-16.0 (Human)]>10 7.3 -4.3 KHS1 UniRef100_Q9Y4K4Mitogen-activatedLys2 proteinDIkGANILLTDHGDVKLADFGVAAK kinase kinase kinase12.4 kinase 51.5 [Homo sapiens-2.3 (Human)]>10 15.5 22.7 LATS1 UniRef100_O95835Serine/threonine-proteinLys1 ALYATkTLRkinase LATS1 [Homo-5.5 sapiens-16.6 (Human)] -13.5 >10 -0.9 -4.8 LCK UniRef100_P06239Proto-oncogeneActivation tyrosine-protein LoopEGAkFPIKWTAPEAINYGTFTIK kinase LCK-13.3 n=2 Tax=Homo-41.6 sapiens-21.9 RepID=LCK_HUMAN>10 3.4 -18.7 LIMK1 UniRef100_P53667LIM domain kinaseLys1 1 [HomoETGEVMVMkELIRFDEETQR sapiens (Human)]-15.6 -15.8 4.0 >10 1.9 -31.1 LIMK1 UniRef100_P53667LIM domain kinaseLys1 1 [HomoETGEVMVMkELIR sapiens (Human)]15.4 -29.1 4.4 >10 44.4 2.4 LKB1 UniRef100_Q15831Serine/threonine-proteinLys2 FPVCQAHGYFCQLIDGLEYLHSQGIVHKDIkPGNLLLTTGGTLKkinase 11 [Homo sapiens0.1 (Human)]2.5 0.5 >10 -23.9 -11.0 LKB1 UniRef100_Q15831Serine/threonine-proteinLys2 DIkPGNLLLTTGGTLKkinase 11 [Homo -0.5sapiens (Human)]4.2 24.2 >10 2.3 -3.2 LOK UniRef100_O94804Serine/threonine-proteinLys1 ETGALAAAkVIETKkinase 10 [Homo-14.0 sapiens (Human)]-1.1 5.5 >10 13.1 9.3 LOK UniRef100_O94804Serine/threonine-proteinLys1 NKETGALAAAkVIETKkinase 10 [Homo sapiens1.4 (Human)]-7.2 -10.3 >10 5.2 13.3 LOK UniRef100_O94804Serine/threonine-proteinLys2 IIHRDLkAGNVLMTLEGDIRkinase 10 [Homo -9.3sapiens (Human)]-51.3 -14.5 >10 -15.5 -30.1 LOK UniRef100_O94804Serine/threonine-proteinLys2 DLkAGNVLMTLEGDIRkinase 10 [Homo sapiens2.4 (Human)]-21.2 0.2 >10 11.6 -6.7 LYN UniRef100_P07948Tyrosine-proteinActivation kinase Lyn LoopEGAkFPIKWTAPEAINFGCFTIK n=1 Tax=Homo-3.9 sapiens RepID=LYN_HUMAN-20.4 -13.2 >10 7.8 -5.0 LYN UniRef100_P07948Tyrosine-proteinLys1 kinase LynVAVkTLKPGTMSVQAFLEEANLMK n=1 Tax=Homo 4.1sapiens RepID=LYN_HUMAN-3.2 -1.4 >10 12.3 -0.1 MAP2K1,MAP2K2UniRef100_Q02750Dual specificityLys2 mitogen-activatedDVkPSNILVNSR protein -15.6kinase kinase-24.3 1 n=4 Tax=Eutheria-16.1 RepID=MP2K1_HUMAN>10 -2.3 14.9 MAP2K3 UniRef100_P46734Dual specificityActivation mitogen-activated LoopMCDFGISGYLVDSVAkTMDAGCKPYMAPER protein kinase-5.7 kinase-49.3 3 [Homo sapiens-26.3 (Human)]>10 -2.6 6.9 MAP2K3 UniRef100_P46734Dual specificityLys2 mitogen-activatedDVkPSNVLINK protein -10.7kinase kinase-18.9 3 [Homo sapiens-11.2 (Human)]>10 0.5 8.6 MAP2K4 UniRef100_P45985Dual specificityLys2 mitogen-activatedDIkPSNILLDR protein -11.1kinase kinase-2.4 4 [Homo sapiens-5.2 (Human)]>10 -0.8 1.7 MAP2K4 UniRef100_P45985Dual specificityActivation mitogen-activated LoopLCDFGISGQLVDSIAkTR protein kinase-6.4 kinase4.7 4 [Homo sapiens1.7 (Human)]>10 7.3 -6.1 MAP2K6 UniRef100_P52564Dual specificityActivation mitogen-activated LoopMCDFGISGYLVDSVAkTIDAGCKPYMAPER protein kinase-5.7 kinase-30.1 6 [Homo sapiens-23.8 (Human)]>10 -13.6 3.3 MAP2K6 UniRef100_P52564Dual specificityLys2 mitogen-activatedDVkPSNVLINALGQVK protein kinase-1.7 kinase-15.1 6 [Homo sapiens-13.2 (Human)]>10 3.0 10.6 MAP2K6 UniRef100_P52564Dual specificityLys1 mitogen-activatedHVPSGQIMAVkR protein kinase2.8 kinase3.0 6 [Homo sapiens0.4 (Human)]>10 5.1 -6.8 MAP2K7 UniRef100_O14733Dual specificityLys2 mitogen-activatedDVkPSNILLDER protein -14.1kinase kinase0.6 7 [Homo sapiens-2.1 (Human)]>10 2.6 -17.5 MAP3K1 UniRef100_Q13233Mitogen-activatedLys2 proteinDVkGANLLIDSTGQR kinase kinase kinase-11.2 1 n=1 Tax=Homo-1.8 sapiens-9.2 RepID=M3K1_HUMAN>10 58.0 -2.1 MAP3K2 UniRef100_Q9Y2U5Mitogen-activatedLys1 proteinELAVkQVQFDPDSPETSKEVNALECEIQLLK kinase kinase kinase10.5 2 n=3 Tax=Homo25.5 sapiens6.7 RepID=M3K2_HUMAN>10 -2.8 12.9 MAP3K2 UniRef100_Q9Y2U5Mitogen-activatedLys1 proteinVYLCYDVDTGRELAVkQVQFDPDSPETSKEVNALECEIQLLK kinase kinase kinase41.1 2 n=3 Tax=Homo2.7 sapiens13.9 RepID=M3K2_HUMAN>10 9.5 10.5 MAP3K2,MAP3K3UniRef100_Q9Y2U5Mitogen-activatedLys2 proteinDIkGANILR kinase kinase kinase-15.8 2 n=3 Tax=Homo-4.1 sapiens-7.2 RepID=M3K2_HUMAN>10 2.5 3.5 MAP3K3 UniRef100_Q99759Mitogen-activatedLys1 proteinELASkQVQFDPDSPETSKEVSALECEIQLLK kinase kinase kinase-15.5 3 n=2 Tax=Homo14.9 sapiens-12.4 RepID=M3K3_HUMAN>10 2.7 12.6 MAP3K4 UniRef100_Q9Y6R4Mitogen-activatedLys2 proteinDIkGANIFLTSSGLIK kinase kinase kinase-11.3 4 [Homo3.8 sapiens (Human)]-10.7 >10 12.5 3.9 MAP3K5 UniRef100_Q99683Mitogen-activatedLys2 proteinDIkGDNVLINTYSGVLK kinase kinase kinase-14.2 5 [Homo-3.8 sapiens (Human)]-8.0 >10 -6.1 -25.7 MAP3K5,MAP3K6,MAP3K7UniRef100_Q99683Mitogen-activatedLys1 proteinIAIkEIPERDSR kinase kinase kinase-14.5 5 [Homo-30.9 sapiens (Human)]-28.1 >10 -5.7 3.9 MAP3K7,TAK1UniRef100_O43318Mitogen-activatedLys2 proteinDLkPPNLLLVAGGTVLK kinase kinase kinase-2.2 7 [Homo0.4 sapiens (Human)]-3.0 >10 41.9 32.5 MAPKAPK3UniRef100_Q16644MAP kinase-activatedATP Loop proteinKYAVTDDYQLSkQVLGLGVNGK kinase 3 [Homo26.5 sapiens -35.4(Human)] -24.0 >10 27.1 3.8 MARK2 UniRef100_Q7KZI7Serine/threonine-proteinLys1 HILTGKEVAVkIIDKTQLNSSSLQKkinase MARK2 [Homo1.6 sapiens-12.8 (Human)] -5.9 >10 -21.9 -53.4 MARK2 UniRef100_Q7KZI7Serine/threonine-proteinLys1 EVAVkIIDKTQLNSSSLQKkinase MARK2 [Homo-12.4 sapiens-24.7 (Human)] 9.0 >10 1.3 -10.1 MARK2,MARK3UniRef100_P27448MAP/microtubuleLys2 affinity-regulatingDLkAENLLLDADMNIK kinase0.4 3 [Homo sapiens2.6 (Human)]8.9 >10 2.6 -13.6 MARK3 UniRef100_P27448MAP/microtubuleLys1 affinity-regulatingEVAIkIIDKTQLNPTSLQK kinase-3.7 3 [Homo sapiens0.0 (Human)]4.5 >10 -9.7 -0.5 MAST1,MAST2UniRef100_Q6P0Q8Microtubule-associatedLys2 serine/threonine-proteinDLkPDNLLITSMGHIK-10.1 kinase-15.7 2 [Homo sapiens-7.6 (Human)]>10 3.5 1.6 MAST2,MAST4UniRef100_Q6P0Q8Microtubule-associatedLys2 serine/threonine-proteinDLkPDNLLVTSMGHIK3.1 kinase-28.0 2 [Homo sapiens-16.1 (Human)]>10 5.7 -8.3 MAST3 UniRef100_O60307Microtubule-associatedLys2 serine/threonine-proteinDLkPDNLLITSLGHIK-0.5 kinase1.6 3 [Homo sapiens5.0 (Human)]>10 2.4 -7.7 MASTL UniRef100_Q96GX5Microtubule-associatedATP Loop serine/threonine-proteinGAFGkVYLGQK -5.2 kinase-like-11.3 [Homo-8.7 sapiens (Human)]>10 17.6 7.6 MASTL UniRef100_Q96GX5Microtubule-associatedLys1 serine/threonine-proteinLYAVkVVK 0.5 kinase-like2.3 [Homo0.2 sapiens (Human)]>10 20.0 1.4 MLK3 UniRef100_Q16584Mitogen-activatedLys2 proteinDLkSNNILLLQPIESDDMEHK kinase kinase kinase11.1 11 [Homo-8.7 sapiens (Human)]-1.6 >10 49.9 0.3 MLKL UniRef100_Q8NB16CDNA FLJ34389Lys1 fis, clone APVAIkVFKHCHON2000087 [Homo-7.7 sapiens20.6 (Human)]2.5 >10 3.4 -11.6 MPSK1 UniRef100_O75716Serine/threonine-proteinLys2 DLkPTNILLGDEGQPVLMDLGSMNQACIHVEGSRkinase 16 n=1 Tax=Homo50.9 sapiens-7.0 RepID=STK16_HUMAN-17.6 >10 86.0 31.8 MSK1 domain1UniRef100_O75582Ribosomal proteinLys2 S6 kinaseDIkLENILLDSNGHVVLTDFGLSK alpha 5 [Homo7.1 sapiens (Human)]4.8 -4.3 >10 16.8 14.0 MSK1,MSK2UniRef100_O75582 domain1 Ribosomal proteinATP LoopS6 kinaseVLGTGAYGkVFLVR alpha 5 [Homo-3.7 sapiens (Human)]-3.2 7.2 >10 8.4 -14.8 MST1 UniRef100_Q13043Serine/threonine-proteinLys1 AIHKETGQIVAIkQVPVESDLQEIIKkinase 4 [Homo sapiens25.7 (Human)]3.3 4.1 >10 8.8 3.6 MST1 UniRef100_Q13043Serine/threonine-proteinLys1 ETGQIVAIkQVPVESDLQEIIKkinase 4 [Homo sapiens33.2 (Human)]21.1 9.0 >10 16.3 21.8 MST1,MST2UniRef100_Q13043Serine/threonine-proteinLys2 DIkAGNILLNTEGHAKkinase 4 [Homo sapiens5.4 (Human)]-61.4 -30.6 >10 -15.2 5.1 MST1,MST2UniRef100_Q13043Serine/threonine-proteinLys2 IHRDIkAGNILLNTEGHAKkinase 4 [Homo sapiens14.5 (Human)]1.6 -5.5 >10 1.2 -8.9 MST1,MST2UniRef100_Q13043Serine/threonine-proteinActivation Loop LADFGVAGQLTDTMAkRkinase 4 [Homo sapiens41.6 (Human)]20.1 18.8 >10 10.9 16.8 MST2 UniRef100_Q13188Serine/threonine-proteinLys1 ESGQVVAIkQVPVESDLQEIIKEISIMQQCDSPYVVKkinase 3 [Homo sapiens-24.8 (Human)]-15.4 -26.1 >10 -57.8 -11.3 MST2 UniRef100_Q13188Serine/threonine-proteinLys1 ESGQVVAIKQVPVESDLQEIIkkinase 3 [Homo sapiens21.3 (Human)]2.1 -7.0 >10 10.3 7.1 MST3 UniRef100_Q9Y6E0Serine/threonine-proteinLys2 DIkAANVLLSEHGEVKkinase 24 [Homo-19.2 sapiens (Human)]-17.2 -17.3 >10 7.2 -16.0 MST3,MST4,YSK1UniRef100_Q9Y6E0Serine/threonine-proteinActivation Loop LADFGVAGQLTDTQIkRkinase 24 [Homo sapiens0.4 (Human)]-3.6 -2.8 >10 -5.0 6.2 MST4 UniRef100_Q9P289Serine/threonine-proteinLys1 TQQVVAIkIIDLEEAEDEIEDIQQEITVLSQCDSSYVTKkinase MST4 [Homo12.3 sapiens -32.9(Human)] 6.5 >10 30.3 5.4 MST4,YSK1UniRef100_O00506Serine/threonine-proteinLys2 DIkAANVLLSEQGDVKLADFGVAGQLTDTQIKRkinase 25 [Homo -3.8sapiens (Human)]-85.8 -31.2 >10 -4.0 -25.7 MST4,YSK1UniRef100_O00506Serine/threonine-proteinLys2 DIkAANVLLSEQGDVKkinase 25 [Homo-14.1 sapiens (Human)]2.8 0.1 >10 12.0 -14.1 NDR1 UniRef100_Q15208Serine/threonine-proteinLys2 DIkPDNLLLDSKkinase 38 [Homo -2.0sapiens (Human)]6.5 7.6 >10 -17.9 -12.1 NDR2 UniRef100_Q9Y2H1Serine/threonine-proteinLys1 DTGHIYAMkILRkinase 38-like [Homo-16.8 sapiens-30.0 (Human)] -8.5 >10 -19.4 -10.7 NEK1 UniRef100_Q96PY6Serine/threonine-proteinLys2 DIkSQNIFLTKkinase Nek1 [Homo-3.7 sapiens (Human)]4.5 6.1 >10 1.2 -7.4 NEK3 UniRef100_P51956Serine/threonine-proteinActivation Loop SkNIFLTQNGKkinase Nek3 [Homo-4.8 sapiens (Human)]-11.9 -0.5 >10 -1.2 1.5 NEK4 UniRef100_P51957Serine/threonine-proteinLys2 DLkTQNVFLTRkinase Nek4 [Homo5.9 sapiens (Human)]10.4 4.3 >10 3.4 -2.8 NEK6,NEK7UniRef100_Q9HC98Serine/threonine-proteinLys2 VMHRDIkPANVFITATGVVKkinase Nek6 [Homo-7.1 sapiens (Human)]-3.2 -5.2 >10 -8.7 -32.9 NEK6,NEK7UniRef100_Q9HC98Serine/threonine-proteinLys2 DIkPANVFITATGVVKkinase Nek6 [Homo-22.2 sapiens (Human)]-40.1 -4.4 >10 -5.3 -4.7 NEK7 UniRef100_Q8TDX7Serine/threonine-proteinLys1 AACLLDGVPVALkKkinase Nek7 [Homo5.4 sapiens (Human)]17.9 4.9 >10 -1.3 0.5 NEK9 UniRef100_Q8TD19Serine/threonine-proteinLys1 RTEDDSLVVWkEVDLTRkinase Nek9 n=1 -14.0Tax=Homo sapiens-26.7 RepID=NEK9_HUMAN-18.3 >10 -3.2 -0.7 NEK9 UniRef100_Q8TD19Serine/threonine-proteinLys1 TEDDSLVVWkEVDLTRkinase Nek9 n=1 Tax=Homo7.1 sapiens-11.8 RepID=NEK9_HUMAN-8.5 >10 1.5 0.0 NEK9 UniRef100_Q8TD19Serine/threonine-proteinActivation Loop LGDYGLAkKkinase Nek9 n=1 Tax=Homo2.2 sapiens-14.4 RepID=NEK9_HUMAN-6.5 >10 8.3 -1.5 NEK9 UniRef100_Q8TD19Serine/threonine-proteinLys2 DIkTLNIFLTKkinase Nek9 n=1 Tax=Homo3.8 sapiens-1.3 RepID=NEK9_HUMAN14.4 >10 8.6 3.5 NuaK2 UniRef100_Q9H093Hypothetical proteinLys1 DKFZp434J037LVAIkSIR [Homo-16.5 sapiens (Human)]4.9 8.5 >10 25.3 7.6 p38a UniRef100_Q16539Mitogen-activatedLys2 proteinDLkPSNLAVNEDCELK kinase 14 n=3 Tax=Eutheria-0.9 RepID=MK14_HUMAN8.2 11.1 >10 2.2 -15.5 p38a UniRef100_Q16539Mitogen-activatedOther proteinQELNkTIWEVPER kinase 14 n=3 Tax=Eutheria33.9 38.1RepID=MK14_HUMAN11.2 >10 2.4 3.0 p38d,p38g UniRef100_P53778Mitogen-activatedLys2 proteinDLkPGNLAVNEDCELK kinase 12 [Homo2.1 sapiens (Human)]-12.1 -14.9 >10 29.3 6.2 p70S6K UniRef100_P23443Ribosomal proteinActivation S6 kinase LoopLTDFGLCkESIHDGTVTHTFCGTIEYMAPEILMR 1 (EC 2.7.1.37)21.9 (S6K) (S6K1)22.3 (70 kDa ribosomal-8.1 protein>10 S6 kinase-26.9 1) (p70 S6 kinase10.3 alpha) (p70(S6K)-alpha) [Homo sapiens (Human)] p70S6K UniRef100_P23443Ribosomal proteinLys2 S6 kinaseDLkPENIMLNHQGHVK 1 (EC 2.7.1.37)-16.4 (S6K) (S6K1)-8.8 (70 kDa ribosomal-2.2 protein>10 S6 kinase-4.4 1) (p70 S6 kinase7.4 alpha) (p70(S6K)-alpha) [Homo sapiens (Human)] p70S6Kb UniRef100_Q9UBS0Ribosomal proteinLys2 S6 kinaseDLkPENIMLSSQGHIK 2 [Homo sapiens0.6 (Human)]-17.3 -13.3 >10 -1.5 -13.1 p70S6Kb UniRef100_Q9UBS0Ribosomal proteinActivation S6 kinase LoopLTDFGLCkESIHEGAVTHTFCGTIEYMAPEILVR 2 [Homo sapiens29.4 (Human)]-19.0 8.0 >10 24.0 -7.5 PAN3 UniRef100_Q58A45PAB-dependentOther poly(A)-specificVMDPTkILITGK ribonuclease-5.4 subunit 3-2.2 10.6 >10 -2.8 -1.2 PCTAIRE1,PCTAIRE3UniRef100_Q00536Serine/threonine-proteinLys2 DLkPQNLLINERkinase PCTAIRE-1 8.1[Homo sapiens5.4 (Human)]12.4 >10 36.0 -8.3 PCTAIRE2 UniRef100_Q00537Serine/threonine-proteinLys2 DLkPQNLLINEKkinase PCTAIRE-224.6 [Homo sapiens9.0 (Human)]20.1 >10 48.5 16.5 PCTAIRE2,PCTAIRE3UniRef100_Q00537Serine/threonine-proteinLys1 SKLTENLVALkEIRkinase PCTAIRE-2-13.8 [Homo sapiens-41.8 (Human)]-25.2 >10 39.9 -2.5 PEK UniRef100_Q9NZJ5Eukaryotic translationLys2 initiationDLkPSNIFFTMDDVVK factor 2-alpha-0.9 kinase 3 -3.5precursor [Homo3.1 sapiens>10 (Human)] 0.3 4.0 PFTAIRE1 UniRef100_O94921Serine/threonine-proteinLys1 VNGKLVALkVIRLQEEEGTPFTAIRkinase PFTAIRE-112.3 n=1 Tax=Homo-7.8 sapiens -7.3RepID=PFTK1_HUMAN>10 27.4 4.7 PFTAIRE1 UniRef100_O94921Serine/threonine-proteinLys2 DLkPQNLLISDTGELKkinase PFTAIRE-1-3.1 n=1 Tax=Homo0.1 sapiens -6.3RepID=PFTK1_HUMAN>10 31.1 0.8 PFTAIRE1 UniRef100_O94921Serine/threonine-proteinLys1 LVALkVIRkinase PFTAIRE-1 8.2n=1 Tax=Homo9.1 sapiens RepID=PFTK1_HUMAN9.1 >10 31.9 2.6 PFTAIRE2 UniRef100_Q96Q40Serine/threonine-proteinLys2 DLkPQNLLISHLGELKkinase ALS2CR7 [Homo1.0 sapiens27.2 (Human)]-0.5 >10 13.9 8.5 PHKg1 UniRef100_Q16816PhosphorylaseLys2 b kinase gammaDLkPENILLDDNMNIK catalytic chain,-0.6 skeletal 4.2muscle isoform-6.3 n=2 Tax=Homo>10 sapiens15.8 RepID=PHKG1_HUMAN11.0 PHKg2 UniRef100_P15735PhosphorylaseLys1 b kinase gammaATGHEFAVkIMEVTAER catalytic chain,6.9 testis/liver-21.8 isoform -21.3[Homo sapiens>10 (Human)]-11.4 -14.2 PI4K2B UniRef100_Q8TCG2PhosphatidylinositolATP 4-kinaseSEEPYGQLNPkWTK type-II beta [Homo-26.5 sapiens-22.1 (Human)]-32.7 >10 -36.4 -7.1 PI4KA,PI4KAP2UniRef100_P42356PhosphatidylinositolATP 4-kinaseSGTPMQSAAkAPYLAK alpha n=2 Tax=Homo6.9 sapiens-18.2 RepID=PI4KA_HUMAN-2.1 >10 78.1 13.6 PI4KB UniRef100_Q9UBF8PhosphatidylinositolATP 4-kinaseVPHTQAVVLNSKDkAPYLIYVEVLECENFDTTSVPAR beta n=2 Tax=Homo4.8 sapiens-22.2 RepID=PI4KB_HUMAN-12.2 >10 96.4 95.0 PI4KB UniRef100_Q9UBF8PhosphatidylinositolATP 4-kinaseVPHTQAVVLNSkDKAPYLIYVEVLECENFDTTSVPARIPENR beta n=2 Tax=Homo4.9 sapiens-14.7 RepID=PI4KB_HUMAN-7.7 >10 97.4 85.7 PIK3C3 UniRef100_Q8NEB9PhosphatidylinositolATP 3-kinaseTEDGGKYPVIFkHGDDLR catalytic subunit90.1 type 3 [Homo62.8 sapiens33.6 (Human)] 0.35 >98 >98 PIK3C3 UniRef100_Q8NEB9PhosphatidylinositolATP 3-kinaseTEDGGKYPVIFkHGDDLRQDQLILQIISLMDK catalytic subunit92.2 type 3 [Homo59.3 sapiens2.9 (Human)] 0.75 96.3 91.5 PIK3CA UniRef100_P42336Phosphatidylinositol-4,5-bisphosphateATP RPLWLNWENPDIMSELLFQNNEIIFKNGDDLRQDMLTLQIIR 3-kinase>80 catalytic>80 subunit alpha39.4 isoform 0.11n=2 Tax=Homo>85 sapiens RepID=PK3CA_HUMAN>85 PIK3CB UniRef100_P42338Phosphatidylinositol-4,5-bisphosphateATP VFGEDSVGVIFkNGDDLRQDMLTLQMLR 3-kinase60.1 catalytic-2.2 subunit beta-9.7 isoform [Homo8.0 sapiens94.5 (Human)] 86.2 PIK3CD UniRef100_O00329Phosphatidylinositol-4,5-bisphosphateATP TKVNWLAHNVSkDNRQ 3-kinase81.0 catalytic51.7 subunit delta8.0 isoform [Homo1.0 sapiens91.2 (Human)] 94.6 PIK3CG UniRef100_P48736Phosphatidylinositol-4,5-bisphosphateATP KkPLWLEFK 3-kinase9.7 catalytic-51.3 subunit gamma-32.5 isoform>10 n=2 Tax=Homo42.7 sapiens32.6 RepID=PK3CG_HUMAN PIP4K2A UniRef100_P48426Phosphatidylinositol-4-phosphateATP AKELPTLkDNDFINEGQK 5-kinase -3.9type II alpha-23.2 (EC 2.7.1.68)-10.6 (1-phosphatidylinositol-4-phosphate>10 8.0 -7.0 5-kinase 2-alpha) (PtdIns(4)P-5- kinase isoform 2-alpha) (PIP5KII-alpha) (Diphosphoinositide kinase 2- alpha) (PtdIns(4)P-5-kinase B isoform) (PIP5KI PIP4K2A,PIP4K2BUniRef100_P48426Phosphatidylinositol-4-phosphateATP TVkHGAGAEISTVNPEQYSKR 5-kinase-25.8 type II alpha-17.7 (EC 2.7.1.68)-11.4 (1-phosphatidylinositol-4-phosphate>10 8.6 -10.2 5-kinase 2-alpha) (PtdIns(4)P-5- kinase isoform 2-alpha) (PIP5KII-alpha) (Diphosphoinositide kinase 2- alpha) (PtdIns(4)P-5-kinase B isoform) (PIP5KI PIP4K2C UniRef100_Q8TBX8Phosphatidylinositol-5-phosphateATP TLVIkEVSSEDIADMHSNLSNYHQYIVK 4-kinase10.1 type-2 gamma-0.1 n=1 Tax=Homo9.0 sapiens>10 RepID=PI42C_HUMAN87.8 48.0 PIP4K2C UniRef100_Q8TBX8Phosphatidylinositol-5-phosphateATP VKELPTLkDMDFLNK 4-kinase -4.4type-2 gamma-28.7 n=1 Tax=Homo-22.5 sapiens>10 RepID=PI42C_HUMAN85.1 44.2 PIP5K3 UniRef100_Q9Y2I7FYVE finger-containingATP phosphoinositideGGkSGAAFYATEDDRFILK kinase18.9 (EC 2.7.1.68)2.3 (1- phosphatidylinositol-4-phosphate0.9 >10 77.9 5-kinase)31.9 (Phosphatidylinositol-3- phosphate 5-kinase type III) (PIP5K) (PtdIns(4)P-5-kinase) [Homo sapiens (Human)] PITSLRE UniRef100_P21127PITSLRE serine/threonine-proteinLys2 DLkTSNLLLSHAGILK kinase CDC2L1-3.9 [Homo-13.8 sapiens (Human)]-23.6 >10 12.1 -0.2 PKD1,PKD2UniRef100_Q15139Serine/threonine-proteinLys2 NIVHCDLkPENVLLASADPFPQVKkinase D1 n=1 Tax=Homo-0.2 sapiens20.2 RepID=KPCD1_HUMAN2.6 >10 18.7 5.4 PKD2 UniRef100_Q9BZL6Protein kinase Lys1D2 [Homo DVAVkVIDKsapiens (Human)]6.8 0.6 -9.4 >10 1.7 9.0 PKD3 UniRef100_O94806Protein kinase Lys1D3 [Homo DVAIkVIDKsapiens (Human)]-15.3 -6.9 1.7 >10 -14.1 3.1 PKD3 UniRef100_O94806Protein kinase Lys2D3 [Homo NIVHCDLkPENVLLASAEPFPQVKsapiens (Human)]-0.9 -2.1 4.5 >10 -4.3 0.8 PKR UniRef100_P19525Interferon-induced,Lys2 double-strandedDLkPSNIFLVDTK RNA-activated-0.5 protein-5.4 kinase -0.5[Homo sapiens>10 (Human)]-4.6 -9.9 PKR UniRef100_P19525Interferon-induced,Activation double-stranded LoopIGDFGLVTSLKNDGkR RNA-activated3.5 protein15.5 kinase [Homo5.8 sapiens>10 (Human)]-1.3 -7.0 PLK1 UniRef100_P53350Serine/threonine-proteinLys1 CFEISDADTKEVFAGkIVPKkinase PLK1 [Homo-16.1 sapiens (Human)]-31.0 -15.8 >10 -7.0 -15.5 PLK1 UniRef100_P53350Serine/threonine-proteinLys2 VIHRDLkLGNLFLNEDLEVKkinase PLK1 [Homo-2.2 sapiens (Human)]-0.5 -6.3 >10 5.7 -3.1 PLK1 UniRef100_P53350Serine/threonine-proteinLys2 DLkLGNLFLNEDLEVKkinase PLK1 [Homo-4.8 sapiens (Human)]-29.6 -5.2 >10 11.4 19.5 PRKACB UniRef100_P22694cAMP-dependentLys2 proteinDLkPENLLIDHQGYIQ kinase catalytic subunit-15.6 beta-23.4 -24.9 >10 24.0 -22.4 PRP4 UniRef100_Q13523Serine/threonine-proteinOther AAGIGkDFKENPNLRkinase PRP4 homolog-8.2 [Homo-21.3 sapiens (Human)]-28.1 >10 -17.2 -12.1 PRP4 UniRef100_Q13523Serine/threonine-proteinLys2 CNILHADIkPDNILVNESKkinase PRP4 homolog-5.3 [Homo-13.5 sapiens (Human)]2.3 >10 -6.5 6.4 PRPK UniRef100_Q96S44TP53-regulatingATP kinase Loop [HomoFLSGLELVkQGAEAR sapiens (Human)]-11.0 -4.0 -11.5 >10 -3.3 -22.9 PYK2 UniRef100_Q14289Protein tyrosineActivation kinase 2 LoopbetaYIEDEDYYkASVTR [Homo sapiens-2.6 (Human)]-11.2 2.4 >10 25.6 14.6 QSK UniRef100_Q9Y2K2Serine/threonine-proteinLys1 VAIkIIDKTQLDEENLKKkinase QSK n=2 Tax=Homo17.8 sapiens8.5 RepID=QSK_HUMAN-17.4 >10 12.9 19.9 RIPK3 UniRef100_Q9Y572Receptor-interactingLys2 serine/threonine-proteinDLkPSNVLLDPELHVK13.0 kinase 313.0 n=1 Tax=Homo17.1 sapiens RepID=RIPK3_HUMAN>10 16.5 -17.6 ROCK1 UniRef100_Q13464Rho-associatedOther protein kinasekLQLELNQER 1 [Homo sapiens10.5 (Human)]4.9 -5.1 >10 -15.3 4.7 ROCK1,ROCK2UniRef100_O75116Rho-associatedLys2 protein kinaseDVkPDNMLLDK 2 [Homo sapiens-1.9 (Human)]-9.0 4.6 >10 -17.3 -3.6 RSK1 domain1UniRef100_Q15418Ribosomal proteinLys2 S6 kinaseDLKPENILLDEEGHIkLTDFGLSKEAIDHEK alpha 1 [Homo-8.5 sapiens (Human)]-40.2 -32.7 >10 13.6 -13.4 RSK1 domain2UniRef100_Q15418Ribosomal proteinLys2 S6 kinaseDLkPSNILYVDESGNPECLR alpha 1 [Homo17.2 sapiens (Human)]7.2 0.6 >10 55.9 12.4 RSK1 domain2UniRef100_Q15418Ribosomal proteinLys2 S6 kinaseTVEYLHSQGVVHRDLkPSNILYVDESGNPECLR alpha 1 [Homo1.8 sapiens (Human)]19.4 -10.4 >10 -38.1 -53.9 RSK1,RSK2 UniRef100_Q15418domain1 Ribosomal proteinLys2 S6 kinaseDLkPENILLDEEGHIKLTDFGLSK alpha 1 [Homo-11.5 sapiens (Human)]-33.5 -24.6 >10 7.0 2.6 RSK1,RSK2,RSK3UniRef100_Q15418 domain1Ribosomal proteinLys2 S6 kinaseDLkPENILLDEEGHIK alpha 1 [Homo10.4 sapiens (Human)]6.6 0.1 >10 14.0 -7.3 RSK1,RSK3UniRef100_Q15418Ribosomal proteinOther S6 kinaseSkRDPSEEIEILLR alpha 1 [Homo-6.0 sapiens (Human)]-18.0 -43.2 >10 31.8 27.4 RSK2 domain1UniRef100_P51812Ribosomal proteinATP LoopS6 kinaseVLGQGSFGkVFLVK alpha 3 [Homo-15.7 sapiens (Human)]-14.0 -12.7 >10 15.3 -6.4 RSK2 domain1UniRef100_P51812Ribosomal proteinActivation S6 kinase LoopLTDFGLSkESIDHEKK alpha 3 [Homo-16.1 sapiens (Human)]5.0 4.8 >10 15.6 2.3 RSK2 domain2UniRef100_P51812Ribosomal proteinLys2 S6 kinaseDLkPSNILYVDESGNPESIR alpha 3 [Homo1.5 sapiens (Human)]0.3 -0.2 >10 25.3 4.5 RSK2 domain2UniRef100_P51812Ribosomal proteinProtein S6 kinaseKinaseSkRDPTEEIEILLR alpha Domain 3 [Homo5.7 sapiens (Human)]10.5 0.7 >10 31.7 18.2 RSKL1 domain1UniRef100_Q96S38Ribosomal proteinProtein S6 kinaseKinaseVLGVIDkVLLVMDTR delta-1 Domain n=2 Tax=Homo3.1 sapiens-4.4 RepID=KS6C1_HUMAN-8.7 >10 -8.6 -3.6 SGK3 UniRef100_Q96BR1Serine/threonine-proteinLys1 FYAVkVLQKkinase Sgk3 [Homo-3.6 sapiens (Human)]-1.7 -3.1 >10 5.5 2.6 SLK UniRef100_Q9H2G2CTCL tumor antigenLys2 se20-9IIHRDLkAGNILFTLDGDIK [Homo sapiens-25.5 (Human)] -76.5 -40.8 >10 -16.0 -29.2 SLK UniRef100_Q9H2G2CTCL tumor antigenLys2 se20-9DLkAGNILFTLDGDIKLADFGVSAK [Homo sapiens-11.7 (Human)] -4.7 -8.7 >10 -6.6 -33.7 SLK UniRef100_Q9H2G2CTCL tumor antigenLys1 se20-9AQNKETSVLAAAkVIDTK [Homo sapiens-10.4 (Human)] -2.8 -8.7 >10 -5.9 -17.8 SLK UniRef100_Q9H2G2CTCL tumor antigenLys2 se20-9DLkAGNILFTLDGDIK [Homo sapiens 16.1(Human)] -44.7 -0.1 >10 17.3 -4.0 SMG1 UniRef100_Q96Q15Serine/threonine-proteinOther DTVTIHSVGGTITILPTkTKPKkinase SMG1 n=443.6 Tax=Homo sapiens1.6 RepID=SMG1_HUMAN-2.5 >10 98.1 85.2 SNRK UniRef100_Q9NRH2SNF-related serine/threonine-proteinLys2 DLkPENVVFFEK kinase10.7 [Homo sapiens27.3 (Human)]5.3 >10 15.7 -0.3 SRPK1 UniRef100_Q96SB4Serine/threonine-proteinLys2 IIHTDIkPENILLSVNEQYIRkinase SRPK1 n=1-7.7 Tax=Homo 4.0sapiens RepID=SRPK1_HUMAN-9.0 >10 4.4 -11.0 SRPK1,SRPK2UniRef100_Q96SB4Serine/threonine-proteinLys1 FVAMkVVKkinase SRPK1 n=1-22.2 Tax=Homo-20.0 sapiens RepID=SRPK1_HUMAN-4.9 >10 -12.6 11.0 STLK5 UniRef100_Q7RTN6STE20-related Activationadaptor protein LoopYSVkVLPWLSPEVLQQNLQGYDAK [Homo sapiens-1.2 (Human)]-7.0 -11.4 >10 -3.0 8.9 SYK UniRef100_P43405Tyrosine-proteinActivation kinase SYK LoopISDFGLSkALRADENYYK [Homo sapiens-9.9 (Human)] -24.7 -14.5 >10 -12.8 -35.7 SYK UniRef100_P43405Tyrosine-proteinLys1 kinase SYKTVAVkILKNEANDPALKDELLAEANVMQQLDNPYIVR [Homo sapiens-7.6 (Human)] -2.5 2.7 >10 -7.0 -33.8 SYK UniRef100_P43405Tyrosine-proteinActivation kinase SYK LoopISDFGLSkALR [Homo sapiens-2.7 (Human)] -19.2 7.1 >10 7.8 3.7 TAO1,TAO3UniRef100_Q9H2K8Serine/threonine-proteinLys2 DIkAGNILLTEPGQVKkinase TAO3 [Homo-13.2 sapiens (Human)]5.9 3.0 >10 15.4 -9.5 TAO2 UniRef100_Q9UL54Serine/threonine-proteinLys2 DVkAGNILLSEPGLVKkinase TAO2 n=2 Tax=Homo4.4 sapiens17.5 RepID=TAOK2_HUMAN5.6 >10 21.5 0.5 TAO3 UniRef100_Q9H2K8Serine/threonine-proteinLys2 KPLQEVEIAAITHGALHGLAYLHSHALIHRDIkAGNILLTEPGQVKkinase TAO3 [Homo-33.1 sapiens -16.9(Human)] -20.8 >10 11.3 1.1 TBK1 UniRef100_Q9UHD2Serine/threonine-proteinLys1 TGDLFAIkVFNNISFLRPVDVQMRkinase TBK1 [Homo1.8 sapiens (Human)]7.3 3.7 >10 -8.6 -8.2 TEC UniRef100_P42680Tyrosine-proteinActivation kinase Tec LoopYVLDDQYTSSSGAkFPVK n=2 Tax=Homo10.1 sapiens RepID=TEC_HUMAN24.2 30.9 >10 -32.1 -36.0 TLK1 UniRef100_Q9UKI8Serine/threonine-proteinLys1 YAAVkIHQLNKkinase tousled-like0.6 1 [Homo -16.6sapiens (Human)]-19.2 >10 -9.4 -12.0 TLK1 UniRef100_Q9UKI8Serine/threonine-proteinLys2 YLNEIkPPIIHYDLKPGNILLVDGTACGEIKkinase tousled-like-0.4 1 [Homo sapiens5.7 (Human)]2.6 >10 5.5 -6.5 ULK3 UniRef100_Q6PHR2Unc-51-like kinaseLys2 3 [HomoNISHLDLkPQNILLSSLEKPHLK sapiens (Human)]18.4 -10.5 -13.5 >10 2.8 -3.4 ULK3 UniRef100_Q6PHR2Unc-51-like kinaseLys1 3 [HomoEVVAIKCVAk sapiens (Human)]-3.7 -8.2 -6.5 >10 3.5 5.9 VRK2 UniRef100_Q86Y07Serine/threonine-proteinLys2 MLDVLEYIHENEYVHGDIkAANLLLGYKkinase VRK2 [Homo-3.5 sapiens (Human)]-6.8 5.6 >10 10.0 18.7 Wee1 UniRef100_P30291Wee1-like proteinLys2 kinase [HomoYIHSMSLVHMDIkPSNIFISR sapiens (Human)]5.1 2.7 6.9 >10 -12.2 -8.0 Wnk1,Wnk2,Wnk3UniRef100_Q9Y3S1Serine/threonine-proteinLys2 DLkCDNIFITGPTGSVKkinase WNK2 [Homo-6.1 sapiens -8.4(Human)] -23.2 >10 0.7 5.0 Wnk1,Wnk2,Wnk4UniRef100_Q9Y3S1Serine/threonine-proteinActivation Loop IGDLGLATLkRkinase WNK2 [Homo-6.6 sapiens -0.4(Human)] 4.8 >10 0.8 -1.3 YANK3 UniRef100_Q86UX6PKE protein kinaseLys2 [HomoDVkPDNILLDER sapiens (Human)]3.4 -3.2 12.3 >10 -3.9 -8.4 ZAK UniRef100_Q9NYL2Mitogen-activatedLys1 proteinWISQDKEVAVKk kinase kinase kinase-4.6 MLT [Homo-8.5 sapiens-12.3 (Human)] >10 82.7 25.6 ZAP70 UniRef100_P43403Tyrosine-proteinActivation kinase ZAP-70 LoopISDFGLSkALGADDSYYTAR [Homo sapiens-7.5 (Human)]-11.1 -36.5 >10 2.7 -6.2 ZC1/HGK UniRef100_O95819Mitogen-activatedLys1 proteinTGQLAAIkVMDVTEDEEEEIKLEINMLKK kinase kinase kinase-18.1 kinase -25.24 [Homo sapiens-14.4 (Human)]>10 14.0 7.8 ZC1/HGK UniRef100_O95819Mitogen-activatedLys1 proteinTGQLAAIkVMDVTEDEEEEIKLEINMLK kinase kinase kinase33.5 kinase 49.8 [Homo sapiens25.5 (Human)]>10 16.3 -5.5 ZC1/HGK,ZC2/TNIK,ZC3/MINKUniRef100_O95819Mitogen-activatedLys2 proteinDIkGQNVLLTENAEVK kinase kinase kinase-9.1 kinase 45.3 [Homo sapiens-4.6 (Human)]>10 40.7 -0.7 0.1uM Torin2 IC50 Torin2 (mM) -9.4 >10 6.2 >10 -43.8 >10 -3.1 >10 12.8 >10 4.0 >10 0.3 >10 >95 <0.01 98.8 <0.01 -2.1 >10 10.9 >10 16.1 >10 2.3 >10 6.5 >10 3.6 >10 12.1 >10 -1.7 >10 -11.3 >10 -17.4 >10 15.0 >10 1.7 >10 6.7 >10 7.3 >10 -5.5 >10 -0.9 >10 -23.0 >10 -7.1 >10 7.6 >10 -8.9 >10 7.5 >10 -25.7 >10 -10.4 >10 -6.0 10 4.0 >10 -3.5 >10 -3.9 >10 -5.7 >10 -1.7 >10 1.6 >10 -3.7 >10 2.7 >10 -25.4 >10 1.1 >10 6.8 >10 8.8 >10 2.6 >10 3.8 >10 0.4 >10 -9.7 >10 -7.2 >10 11.4 >10 11.3 >10 3.9 >10 14.1 >10 -1.5 >10 -12.5 >10 98.2 <0.01 97.2 <0.01 96.8 <0.01 3.0 >10 -0.9 >10 -0.8 >10 17.3 >10 11.9 >10 16.0 >10 5.9 >10 98.2 <0.01 7.2 >10 3.3 >10 -5.3 >10 -3.4 >10 -1.4 >10 4.4 >10 -0.3 7.3 -4.9 >10 5.3 >10 -3.7 >10 3.3 >10 0.4 >10 1.4 >10 -14.2 >10 2.6 >10 2.6 >10 2.3 >10 -11.6 >10 -6.6 >10 -5.9 >10 -4.3 >10 -0.8 >10 -1.2 >10 -4.0 >10 3.6 1.0 -18.9 >10 1.7 >10 -5.7 >10 -11.9 >10 4.1 9.7 -15.9 >10 23.1 >10 1.8 >10 -4.7 >10 -3.3 >10 -4.0 >10 13.9 >10 -4.8 >10 3.3 >10 2.8 >10 -4.2 >10 -5.6 >10 -1.0 >10 7.6 >10 0.7 >10 17.6 >10 8.3 >10 9.2 >10 -2.1 >10 12.1 >10 5.5 >10 3.0 >10 7.3 >10 3.1 8.7 3.9 >10 -8.3 >10 -2.5 >10 12.6 >10 -9.0 >10 -2.4 >10 6.2 >10 18.5 >10 21.9 >10 -25.4 >10 -5.2 >10 -9.0 >10 -2.6 >10 16.4 >10 4.3 >10 -3.2 >10 0.0 >10 6.2 >10 14.3 >10 -8.0 >10 17.6 2.2 6.1 >10 -8.5 >10 1.0 >10 10.1 >10 19.9 >10 13.9 >10 9.3 >10 36.3 >10 1.9 >10 1.2 >10 -0.7 >10 25.9 >10 -5.6 >10 0.7 >10 1.3 >10 9.7 >10 -9.1 >10 2.6 >10 -5.8 >10 -15.2 >10 3.0 >10 4.5 >10 3.6 >10 -0.9 >10 4.6 >10 -2.3 >10 1.4 >10 -13.4 >10 -1.9 >10 8.4 >10 -2.2 >10 0.7 >10 3.5 >10 -13.7 >10 -2.5 >10 -12.2 >10 2.5 >10 5.0 >10 -2.9 >10 16.4 >10 -2.5 >10 2.2 >10 5.0 >10 4.4 >10 -6.8 >10 2.4 >10 -3.9 3.9 50.8 0.093 43.4 0.13 92.5 <0.01 83.1 0.014 >85 <0.01 34.2 0.18 79.2 0.018 14.5 >10 8.9 >10 1.2 >10 15.6 0.99 16.8 1.1 10.5 2.0 5.3 >10 5.2 >10 7.2 >10 -2.2 >10 4.5 >10 -4.7 >10 -9.0 >10 -6.0 >10 0.2 >10 10.9 >10 -5.5 >10 -2.3 >10 3.4 >10 -10.1 >10 10.0 >10 -9.3 >10 -27.7 >10 -4.0 >10 7.1 >10 6.2 >10 -1.6 6.8 -43.4 >10 9.7 >10 -5.4 >10 0.8 >10 -4.2 >10 6.6 >10 4.7 >10 13.7 >10 -7.4 >10 -5.5 >10 -2.1 >10 -5.3 >10 0.1 >10 -10.5 >10 21.7 0.27 3.9 >10 0.6 >10 -0.3 >10 11.7 >10 -9.3 >10 -6.0 >10 3.5 >10 -3.1 >10 4.0 >10 40.0 >10 -1.5 >10 -16.3 >10 -13.1 >10 2.3 >10 2.7 >10 4.9 >10 7.9 >10 -3.1 >10 -4.1 >10 4.1 >10 -18.2 >10 1.8 2.6 -1.2 >10 6.3 >10 -26.8 >10 -4.2 >10