ANTIMICROBIAL AGENTS AND CHEMOTHERAPY VOLUME 38 0 DECEMBER 1994 0 NUMBER 12 Robert C. Moellering, Jr., Frederick G. Hayden, Editor (1995) Editor in Chief (1995) University of Virginia Health New England Deaconess Hospital Sciences Center Boston, Mass. George L. Drusano, Editor (1998) Charlottesville, Va. Albany Medical College Michael Barza, Editor (1995) Albany, N.Y Barbara E. Murray, Editor (1997) New England Medical Center Thomas D. Gootz, Editor (1995) University of Texas Health Science Hospitals Pfizer Inc. Center Boston, Mass. Groton, Conn. Houston, Tex. Karen Bush, Editor (1999) Herbert A. Kirst, Editor (1996) American Cyanamid Lilly Research Laboratories Pearl River, N.Y Indianapolis, Ind. EDITORIAL BOARD Peter C. Appelbaum (1994) George M. Eliopoulos (1994) Gary R. Matzke (1995) Richard S. Schwalbe (1994) Gordon L. Archer (1995) Roberta M. Fontana (1996) Douglas Mayers (1994) Charles Shipman, Jr. (1994) Devron R Averett (1996) John N. 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Abruzzo, G., 2750 Ellis, Brian, 2803 Kormbluth, Richard S., 2910 Radwanski, Elaine, 2758 Afrime, Melton B., 2758 Ellis, M. Nixon, 2792 Krogstad, Paul,.2929 Radzilowski, E., 2827 Agfindez, J. A. G., 2798 Entenza, J. M., 2683 Kukla, Michael J., 2863 Rando, Robert F., 2889 Andrei, G., 2710 Kurtz, M. B., 2750 Rathod, Pradipsinh K, 2871 Andries, Koen, 2863 Felgner, Jiin, 2792 Reardon, John E., 2743 Appelbaum, P. C., 2905 Felgner, Phillip L, 2792 Lagente, Michel, 2857 Reed, Michael D., 2817 Appelbaum, Peter C., 2902 Fennewald, Susan M., 2889 Iam, Kan, 2803 Reina, Jordi, 2917 Armstrong, M. E., 2827 Fernxindez-Gallardo, L. C., Lambe, Catherine U., 2722 Revankar, Ganapathi R., 2889 2798 Lambert, Thierry, 2925 Ricci, John, 2792 Baldwin, J., 2827 Fluckiger, U., 2846 Lecomte, S., 2810 Richman, Douglas D., 2792, Balkovec, J. M., 2750 Francioli, P., 2846 Le Conte, P., 2695 2910 Banzarini, J., 2710 Frick, Lloyd W., 2722 Le Gallou, F., 2695 Robinson, Tonya, 2883 Baron, D., 2695 Lemon, Eloise, 2817 Roilides, Emmanuel, 2883 Baron, M. H., 2810 Garcia, M. L., 2750 Letting, Dorcas J., 2689 Ros, Maria Jesus, 2917 Bartizal, K, 2750 Gardner, Mfichael F., 2792 Lewis, Arthur F., 2889 Rosing, Hilde, 2763 Beijnen, Jos H., 2763 Garrigues, Jean Christophe, Lewis, J., 2827 Rybak, Michael J., 2702 Benitez, J., 2798 2857 Lin, Chin-Chung, 2758 Saito, H., 2877 Bergogne-Berezin, E., 2780 Gassis, Safwat, 2871 Linas, Marie Denise, 2857 Sato, K, 2877 Bermudez, Luiz E., 2717 Georgakopoulos; Kathleen, Ludewig, Gabriele, 2850 Schentag, Jerome J., 2730 Bickle, M., 2846 2785 Lutz, Colleen, 2871 Schols, Dominique, 2863 Billstein, Stephan A., 2679 Giamarellou, Helen, 2925 Sedefio, J., 2798 Blaser, J., 2846 Glauser, M. P., 2683, 2846 Maesaki, Shigefumi, 2843 Seguela, Jean Paul, 2857 Blatter, M., 2683 Goldfarb, Johanna, 2817 Mandala, S., 2750 Sein, Tin, 2883 Blumer, Jeffrey L., 2817 Marfinan, J., 2750 Selleseth, Dean W., 2792 Bouffard, F. A., 2750 Hammond, M. L, 2750 Martin, J. Louise, 2743 Selnick, H., 2827 Bourgeois, M., 2827 Hara, Kohei, 2843 Matthews-Davis, Nicole, 2743 Seo, Susan M., 2702 Bourlioux, Pierre, 2925 Hastings, J., 2827 MdClements, W., 2827 Serra, Antonio, 2917 Breslin, Henry J., 2863 Hazuda, D., 2827 McGrath, Betty J., 2702 Shirtliff, Mark E., 2768 Brown, Chadwick E., 2743 Heifets, Leonid, 2738 McManus, 0. B., 2750 Smith, G., 2827 Bult, Auke, 2763 Helsberg, M., 2710 Meenhorst, Pieter L., 2763 Snoeck, R., 2710 Burger, David M., 2763 Hoskins, Stephen L, 2768 Meylan, Pascal R. A., 2910 Sommadossi, Jean-Pierre, 2889 Hostetler, Karl Y., 2792 Mezo, Nancy, 2738 Spangler, Sheila K, 2902 Cadet De Fontenay, G6rald, Hsu, Shari A., 2785 Milligan, J., 2750 Sridhar, C. N., 2792 2857 Huang, Hua-Bin, 2896 Mittler, E. Stewart, 2785 Staben, Chuck, 2850 Cayen, Mitchell N., 2758 Hulman, John H., 2889 Mojaverian, Parviz, 2758 St. John, Lisa, 2722 Chen, Minjun, 2838 Hyatt, Judith M., 2730 Monath, Thomas P., 2785 Struillou, L., 2695 Cheng, Yulin, 2838 Monteil, H., 2780 2929 Chenon, M. T., 2810 Ibanez, Maria A., 2908 Mor, Natan, 2738 Swanstrom, Ronald, Chin, Nai-Xun, 2896 Inderlied, Clark B., 2717 Moreau, N. J., 2810 Taylor, Lester C., 2722 Colmenero, J. D., 2798 Moreillon, P., 2683, 2846 Tebben, A., 2827 Costerton, J. William, 2803 Jacobs, Michael R., 2902 Morse, Gene D., 2689 ten Napel, Chris H. H., 2763 Coupry, C., 2810' Jacobs, M. R., 2905 Mulder, Jan W., 2763 Thompson, J., 2750 Courvalin, Patrice, 2925 Jihne, G., 2710 Muller-Serieys, C., 2780 Tomassini, J., 2827 Jansen, R. W., 2921 Tomioka, H., 2877 Davies, M. E., 2827 Janssen, Marcel A. C., 2863 Nelson, Donald J., 2722 Trieff, Norman M., 2768 Davis, C. Patrick, 2768 Janssen, Paul A. J., 2863 Neu, Harold C., 2896 Valverde, E., 2798 Davis, M. G., 2921 Jehl, F., 2780 Nets, J., 2710 Vanderkolk, Julie, 2738 Debyser, Zeger, 2863 Johnson, Frank, 2803 Nix, David E., 2730 Virta, Marko, 2775 De Clercq, E., 2710 Nollstadt, K, 2750 Pauli, 2775 De Clercq, Erik, 2863 Kaatz, Glenn W., 2702 Norbeck, Daniel W., 2929 Vuorinen, Dekio, S., 2877 Kaku, Mitsuo, 2843 Walsh, Thomas J., 2883 de Larminat, V., 2780 Kang, S. Lena, 2702 O'Donnell, Alice M., 2689 Warren, Michael M., 2768 DeRemer, Mary F., 2689 Kaplan, Andrew H., 2929 Onishi, J., 2750 Weltzin, Richard, 2785 Desmyter, Jan, 2863 Karp, Matti, 2775 Winkler, I., 2710 Dhople, Anita A., 2908 Kempf, Dale J., 2929 Pankuch, G. A., 2905 Woestenborghs, Robert, 2863 Dhople, Arvind M., 2908 Khosla, Mala, 2871 Pauwels, Rudi, 2863 Wolfe, A., 2827 Douglas, C., 2750 Khoury, Antoine E., 2803 Petrofsky, Mary, 2717 Yamashita, Toyoko S., 2817 Drach, John C., 2889 Klein, Oscr, 2896 Pizzo, Philip A., 2883 Young, Lowell S., 2717 Dreikorn, S., 2750 Koga, Hironobu, 2843 Ploy, Marie-Cecile, 2925 Young, Robert D., 2871 Dropinski, J. F., 2750 Kohno, Shigeru, 2843 Ponticello, G., 2827 Drugeon, H B., 2695 Koks, Cornelis H. W., 2763 Potel, G., 2695 Zambias, R. A., 2750 Duyts, Tineke, 2763 Kolonoskd, Peter, 2717 Ptak, Roger G., 2889 Zbinden, Irene, 2910 ACKNOWLEDGMENT

The following persons served as invited special reviewers for the journal during 1994, and their help is greatly appreciated. Sheldon Aaronson M. Cory Simeon Goldblum B. G. Kennedy Stephen Morse C. Agouridas J. W. Costerton E. C. J. Goldstein G. E. Kenny J. M. Mullin N. E. Allen Howard Cottam Gary L. Gorby Earl Kern R. S. Munford Carl Alving Donald Craven V. Gordeuk Jay S. Keystone Izumi Nakashima Raza Aly Alfred Crowle Michael Gottlieb S. Klebanoff Yuziro Namba S. G. B. Amyes Bryan Cullen M. A. Gougerot-Pocidalo Jerome Klein P. K Narang Deborah Anderson E. Cundliffe Richard Granneman Michael Kleinberg Mohamed Nasr R. Anderson Marinos Dalakas J. R. Graybill Sally Klemens Reza Nassiri Koen Andries Richard D'Aquilla S. J. Green Mark Klempner Jay Nelson S. Arai Franz Daschner Jeffrey Griffiths A. L. Koch T. Nicas Fausto Araujo Raymond Dattwyler Max Grogl Steve Kohl Ron Nichols Roberto Arduino Robert Daum Jerome Groopman Brent Korba S. D. Nightingale Eurico Arruda Peter G. Davey Jessie Groothuis J. A. Korvick Hiroshi Nikaido Michel Arthur Julian Davies Dieter Groschel Joseph Kovacs David Nix D. A. Ashtekar C. P. Davis J. H. Grosset Thomas Kozell Daniel Norbeck Mitchell Avery E. Patchen Dellinger S. Gudmundsson Bruce Kreter Frank Odds B. M. Babior B. Demple Laurent C. Gutmann Helmut Kropp Andrew Onderdonk Cyrus Bacchi A. Denis Richard Hafner T. Krulwich J. Orfila Fernando Baquero Francis Derouin Regine Hakenbeck Robert LaFemina I. M. Orme Alan Barbour Richard Diamond G. Hall J. H. Lakey Michael Otto Neil Barg Charles Dinarello Ruth Hall Brandon Larder Andr6 Ouellette Steven Barriere Julie Djeu Wendell Hall Timothy Lasar Gary Overturf K F. Bartizal Thomas J. Dougherty B. Halliwell Belle Lee Joseph Pagano Larry Bauer R. Gordon Douglas Davidson Hamer Matthew Levison Peter Palese Denis Beauchamp John Drach I. R. Hamilton Daniel Lew Tim Palzkill C. Bebear Larry Drew J. M. T. Hamilton-Miller Paul Lietman L. W. Parks John Bennett Donald Dubin M.-L. Hammerskjold Pin-Fang Lin Jan Patterson Michael Bennish W. M. Dunne D. J. Hardy Philip D. Lister Jean-Claude Pechere C. A. Benson Herbert Dupont James Harnisch David Livermore Charles Penn Brigitte Berger-Bachi Frank Dutko J. V. Heck Richard Locksley Miercio Pereira Jonathan Berman Dennis Dwyer Richard Hector Antonio Lopez Robert Perkins L. E. Bermudez Paul H. Edelstein M. Henry G. Lopez-Berenstein C. Perno Kevin Bertrand T. D. Edlind Betty Herndon Phillip Mackowiak C. Perronne Frank Bia John Edwards Mathias Herrmann Dennis Maki Edward Pesanti John A. Bilello J. M. Ehret Robert Hertberg M. H. Malamy W. Peters Jeffrey L. Blumer Anton Ehrhardt David R. Hill R. Marre Jaques Bolard Emilio Emini S. L. Hillier B. J. Marshall David Peterson Daniel P. Bonner Robert Eng T. B. Hinshaw W. J. Martin Lance Peterson John Boothroyd Ron Fayer M. J. M. Hitchcock P. K Mascharak William Petri P. T. Borgia Mary Jane Ferraro J. V. Holtje Anthony Maxwell Michael A. Pfaller F. Douglas Boudinot Giora Feuerstein Thomas Hooton William McCabe Elmer Pfefferkorn E. Boudreau Gregory Filice L. A. Horrocks Glenn McConkey Alain Philippon E. J. Bowman Scott Filler G. H. Hottendorf W. M. McCormack Gerald Pier John Boyce Courtney Fletcher W. T. Hughes G. H. McCracken A. Plasz C. Brinckerhoft Mary Fling Pentii Huovinen J. E. McDade J. J. Pocidalo Itzhak Brook Harry Flynn Joseph R. laconis J. W. McFarland Matthew Pollack M. R. W. Brown Dunne Fong Julia Inamine John McGowan Richard Pollard Sheldon Brown Alan Forrest C. B. Inderlied R. McLeod Bruce Polsky Robert Brummett H. Fraimow William Jacobs Gerald Medoff L. F. Povirk James Brunton Scott Franzblau Nilda Jacobus Cody Meissner D. A. Preston Thomas Butler C. Frey Edward L. Jarroll Peter C. Melby Steven Projan Enrico Cabib David Fromtling Baohong Ji Carmen Mendoza Sherry F. Queener Joseph Calocino Patricia Fultz Joseph F. John, Jr. Thomas Merigan John P. Quinn Stephen A. Chartrand Phillip Furman David Johns Jay Merluzzi J. A. Radding V. J. Chen Murray Gardner David Johnson W. G. Merz Ann Rajnicek Yung-Chi Cheng Patricia Gardner J. L. Johnson Steven Meshnick Reuben Ramphal Ambrose Cheung P. R. J. Gangadharam Victoria Johnson David Metzler Didier Raoult K. D. Chirgwin Robert Gelber Margaret Johnston Richard D. Meyer Neil Rastogi Ian Chopra Layne Gentry P. Johnston Wayne Meyers Thomas Rea Joanna Clancy John Gerin Keith A. Joiner Yuzuru Mikami D. E. Reed A. B. Clarkson M. A. Ghannoum R. N. Jones William Mitchell Michael Reed T. E. Clendennen David Gilbert Bernard Joris Harry L. T. Mobley R. L. Regnery Don B. Clewell Peter Gilbert R. L. Juliano Robert Modlin David Rekosh Tracey Coffey Charles M. Ginsburg Allen Kaiser Larry Mole Jack Remington Myron Cohen Arthur Girard S. W. Kaldor Robert Moore Philip Reyes Stewart Cole Richard H. Glew Edna Kaneshiro Glenn Morris E. Reynolds E. Collatz Andr6 Goffeau Thomas Kanyuk David Morrison Louis Rice Michael Corrado B. Goldberg Sheldon Kaplan Gene Morse G. L. Ridgway Y. Rikihisa George Shaw Larry Strausbaugh Jashvant Unadkat John W. Warren M. G. Rinaldi J. M. Shaw Kate Sullivan Eric Utt C. Watanakunakorn Michael K Riscoe Karen Joy Shaw Lars Sundstrom A. H. C. Uttley T. E. Wellens Philip Rosenthal Cheng-Kon Shih Brian Swanson Martti Vaara Richard Wenzel Ethan Rubenstein Gerald Shockman Michael Syvanen Hugo vanden Bossche Joseph Wheat Leon Sabath W. A. Simpson K Takayama H. W. van Wart J. C. Williams Nieto J. Saez P. L. Skatrud S. K Tanaka Jonathan Vennerstrom Walter Wilson Jan Sahai L. N. Slater W. Daniel Sahm Edgar Smith Gary Tarpley Mary Vermeulen J. Wolf Christine Sanders James Smith Martin Tauber J. Vila E. Wolinsky G. M. Scalarone Jeffrey Smith David Taylor Govinda Visvesvara K V. Wood Julius Schachter Rosemary Soave Amalio Telenti Volker Vogt Martin Woodle Dennis Schmatz J. D. Sobel Margaret Tisdale Kaye Wachsmuth Phillip Wyde G. P. Schmid Joseph Solomokin Richard Titus Mark Wainberg D. M. 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Abadi, Fariborz J. R., 1256 Aronovitz, Gerson, 315 Bassi, C., 830 Bischofberger, Norbert, 2387 Abadia, A., 632 Arri, Carol J., 260 Bateson, John H., 991 Bisignano, Giuseppe, 2651 Abadie, V., 1209 Arruda, E., 1425 Battaglia, Steven, 1303 Bito, Arnold, 1172 Abbas, H., 830 Arruda, Eurico, 66 Bauchet, Jacqueline, 1953 Black, Paul H., 1, 7 Abbott, K. H., 608 Arsenijevic, Denis, 1803 Bauer, Gerhard, 1386 Blahy, Olga M., 1404 Abdalla, Salah, 2668 Arthur, Michel, 1899 Bauer, Jens, 1501 Blaimont, Brigitte, 1675 Abdelghaffar, Houria, 1548 Arts, Eric J., 1008 Baughman, William L., 781 Blaser, J., 2846 Abe, Chiyoji, 2380 Asawamahasakda, Wanida, Baumgartner, J. D., 1309 Blatter, M., 2683 Abel, Steven R., 2101 1854 Bayer, Arnold S., 729, 1460 Blondelle, Sylvie E., 2280 Abramowsky, Carlos, 83 Ash, Peter W., 504 Beale, Angela S., 1937 Blum, M. Robert, 1534, 1590 Abrams, Michael, 668 Atanasova, Ivanka, 981 Beattie, Shona, 2357 Blumer, Jeffrey L., 2817 Abruzzo, G., 2750 Atassi, Maha, 326 Beatty, Carolyn C., 604 Bocanegra, R., 1604 Abuin, C. M. Franco, 1655 Atkinson, B. A., 1604 Beauchamp, Denis, 54, 189, Bodey, Gerald, 624 Acar, J. F., 2218 Au, Jessie L.-S., 1573 742, 750, 1027, 1555 Bodey, Gerald P., 134, 848 Acharya, Gopal, 2415 Aubertin, Anne-Marie, 1292 Beaulac, C., 1090 Bodey, G. P., 602 Adams, Ruth L., 1567 Auckenthaler, R., 1309 Beaulieu, Danielle, 937 Bodor, Frank, 315 Advikolanu, Kavitha, 1490 Aurelian, L., 675 Beauvais, Bernadette, 2440 Bodor, Nicholas, 817 Affrime, Melton B., 2758 Averett, Devron R., 616, 868, Becker, Jeffrey M., 648 Boersma, W. G., 872 Agarwal, Anshu, 588 1230, 1590 Beckett, Laurel A., 307 Bogaerts, Jos, 1647 Ager, A., 1753 Avril, Jean Loup, 438 Beckthold, Brenda, 1944 Bogaki-Shonai, Mayumi, 2014 Ager, A. L., 1862 Aweeka, Francesca T., 1190 Bedikian, Annet, 151 Bohm, Rudolf P., 1277 Agrofoglio, Luigi A., 2300 Ayala, Juan, 2150 Bedos, Jean-Pierre, 1953 Bohnen, John M. A., 2671 Agundez, J. A. G., 2798 Ayers, Kenneth M., 1590 Begg, E. J., 2480 Bolard, Jacques, 300, 963, 1079, Aikawa, M., 2258 Azeddoug, Houssine, 1047 Beggs, William H., 363 2373 Ajiki, Yoko, 138 Azoulay-Dupuis, Esther, 1953 Behm, Frederick G., 1644 Bollen, Alex, 969 Akahane, Kouichi, 2323 Beijnen, Jos H., 2763 Bonacorsi, Stephane P., 2655, Alaya, Majed, 396 Baba, Masanori, 688 Bekersky, Ihor, 79 481 Aldegheri, Marco, 1980 Babe, Lilia M., 2430 Belfayol, Laurence, 620 Bonora, A., 830 Alder, J., 1071 Bacchi, Cyrus J., 563 Belisle, John T., 330 Boon, Ron, 2454 Aldrich, P. E., 1635 Bacher, John, 713 Belliveau, Paul P., 2449 Bor, Amir, 2336 Aldridge, Kenneth E., 889, Bajaksouzian, Saralee, 1794 Benedetti, Jacqueline, 174 Borczyk, A. A., 2121 1671 Baker, E. R., 2458 Benini, A., 830 Bordon, Florence, 1085 Alfieri, Caroline, 126 Baker, H., 2458 Benitez, J., 2798 Borner, K., 455 Ali, Nasr M., 1303 Bakker-Woudenberg, Irma A. Bennett, Donald, 604 Borobio, Maria Victoria, 1442 Allende, Maria C., 518, 1303 J. M., 147 Bennett, Tamara K., 1711 Borotz, Susan E., 31 Allerheiligen, Sandra, 1178 Baldanti, Fausto, 38 Ben-Yaacov, Rina, 648 Bosio, Anne-Marie, 620 Allison, Anthony C., 126 Baldi, Gabriella, 2605 Berardi, Rosemary R., 326 Bossard, Gerald E., 504 Al-Obeid, Suleiman, 824 Baldwin, J., 2827 Berche, Patrick, 438 Bostrom, Alan, 260 Amantea, Michael A., 713, Balfour, Henry H., Jr., 604 Berenguer, Juan, 518, 1303 Bottger, Erik C., 228, 381 1580 Balis, F. M., 1726 Berger, Bradley J., 1298 Boudinot, F. Douglas, 504 Amicosante, Gianfranco, 1608 Balkovec, J. M., 2750 Berger-Bachi, Brigitte, 724 Boudinot, Sally G., 504 Amor, Penelope, 719 Balliano, Gianni, 1904 Bergeron, Michel G., 54, 189, Bouffard, F. A., 2750 Amouroux, Jacques H., 481 Balzarini, J., 2180, 2710 742, 750, 1027, 1555 Bouhajib, M., 1090 Amyes, S. G. B., 2143 Balzarini, Jan, 668 Bergeron, Yves, 54, 750, 1555 Boukari, Madjid, 620 Anaissie, Elias, 624 Banevicius, Mary A., 2449 Bergogne, Marie-Christine, Bourgeois, M., 2827 Anaissie, Elias J., 2541, 2660 Bange, Franz-Christoph, 228 1292 Bourget, Philippe, 1953 Anastasi, Alessandro, 2221 Baquero, Fernando, 122, 2150 Bergogne-Berezin, E., 2780 Bourlioux, Pierre, 2925 Anastassiadou, H., 602 Barakbah, Y., 2530 Berman, J., 1753, 1862 Bourne, David W. A., 2392 Andersen, S. L., 1753, 1862 Barbabietola, Giuliana, 2041 Bermudez, Luiz E., 1200, 1844, Bouza, Emilio, 1879 Anderson, Bradley D., 1107 Barbara-Burnham, Lucia, 1838 2717 Bowman, Lee, 2101 Anderson, J. W., 1397 Barbareschi, Mauro, 2605 Bermudez, Luiz E. M., 1838 Bowsher, Ronald R., 2134 Anderson, M. Marie, 96 Barbhaiya, R. H., 2210 Berne, Thomas V., 151 Boyd, Malcolm, 719 Andrei, G., 2710 Barcelo, Anna, 2477 Bernstein, David I., 2059 Boyer, Paul L., 1909 Andrews, J. M., 1096, 2369 Barchiesi, Francesco, 1530, Berryman, David I., 1041 Bradford, Patricia A., 761 Andries, Koen, 2863 2553 Bertazzoni, E. M., 830 Bradley, Charles A., 2415 Andriof, Elena, 681 Barclay, M. L., 2480 Bertino, Joseph S., Jr., 499 Bradley, Suzanne F., 326, 2495 Apitz, Rafael, 337 Baretton, G., 2564 Betriu, Carmen, 2183 Brajtburg, Janina, 294, 300 Appelbaum, P. C., 211, 369, Barkhimer, David B., 2387 Betts, Robert F., 1178 Brandt, Claudia M., 2191 898, 2065, 2317, 2471, 2599, Baron, D., 2695 Bevilacqua, Maurizio, 2605 Branger, J. M., 415 2905 Baron, Denis I., 883 Beyer, J., 1071 Breen, Gail A., 2227 Appelbaum, Peter C., 2902 Baron, M. H., 2810 Beyer, Jill, 1496 Brennan, Tara M., 1780 Appleman, Maria D., 151 Barrett-Bee, Keith J., 403 Beyer, Jorg, 911 Breslin, Henry J., 2863 Arakawa, Yoshichika, 71 Barrow, William W., 2287 Bhakdi, Sucharit, 13, 1331 Brewer, Thomas G., 1813 Araujo, Fausto G., 570 Barry, Arthur L., 2419 Bialer, Meir, 2336 Brewster, Marcus E., 817 Arbol, Francisca, 1103 Barsanti, F., 345 Bickle, M., 2846 Bridger, Gary, 668 Archer, Gordon L., 447, 2231 Barthold, Stephen W., 1567 Bilello, John A., 628, 1386 Bridges, C. Gordon, 1780 Arduino, Jean-Marie, 307 Bartizal, K, 2750 Bille, J., 1309 Bridges, Edward G., 924 Arisawa, Mikio, 1966 Bartlett, John A., 799 Billich, Andreas, 1763 Brierton, Dennis G., 2101 Armstrong, M. E., 2827 Bartlett, Marilyn S., 1834, 1859 Billot-Klein, Danielle, 824 Brisseau, Guy F., 2671 Arnold, Edward, 1909 Bartlett, M. S., 378 Billstein, Stephan A., 2679 Brocavich, Joseph M., 2227 Arnold, Renate, 465 Basco, Leonardo K, 1169 Bingen, Edouard H., 2655 Brodkey, Terri O., 1644 i ii AUTHOR INDEX ANTIMICROB. AGENTS CHEMOTHER.

Broeders, P. H. M., 487 Casadevall, Arturo, 580, 1507, Coakley, Dion, 1534 Darouiche, Rabih O., 1059 Brookshire, Kenneth W., 2633 1695, 2029, 2648 Coe, Christopher J., 1515 Dassiou, M., 602 Broun, E. Randolph, 576 Casellas, Jose M., 2150 Cohen, B. Eleazar, 1079 Datema, Roelf, 668, 1763 Brown, B. A., 1408 Cattel, Luigi, 1904 Cohen, Robert, 2655 Dautrey, Sophie, 757 Brown, Barbara A., 381 Causey, Dennis, 1190 Cohen, Sofie, 374 Davey, P. G., 1356 Brown, Chadwick E., 2743 Cawood, Pamela G., 1628 Colacino, J. M., 1997 Davey, Richard T., Jr., 1580 Brown, L., 1753 Cayen, Mitchell N., 2758 Cole, G., 534 Davidson, Ross J., 1165 Brown, Melissa H., 2311 Cercenado, Emilia, 49 Cole, Gerald A., 1386 Davies, Gareth M., 403 Brown, S., 2121 Cerniglia, Giuseppa, 2651 Cole, Stewart T., 238, 773 Davies, M. E., 2827 Bruce, Andrew W., 1490 Cerruti, F., 1219 Collatz, Ekkehard, 824 Davio, Stephen R., 1277 Bruguerolle, Bernard, 901 Ceruti, Maurizio, 1904 Collier, Ann C., 604 Davis, C. Patrick, 2768 Brummer, Elmer, 460, 2158, Cesana, Marina, 2651 Collins, Linda A., 144 Davis, Gray, 174 2162 Challier, Svetlana, 2440 Colmenero, J. D., 2798 Davis, M. G., 2921 Bruna, Costantino Della, 2346 Chambers, Henry F., 2568 Colombo, A. L., 1604 Davis, Roger, 1190 Bruno, R., 733 Chambers, S. T., 2480 Colombo, Arnaldo L., 1530, Day, Nicholas P. J., 1716 Brunton, J., 1678 Chan, Francis T. H., 1157 2553 Dazin, Paul F., 1460 Brusa, Paola, 1904 Chan, Gertrude P., 61, 515, Colombo, Delia, 2605 Dean, Brenda J., 2633 Bryan, Larry E., 1944 1651 Cometta, A., 1309 Dean, Robert, 1834 Bryskier, Andre, 1433 Chanal, Catherine, 2452 Compton, Joyce A., 2134 DeAngelis, B., 2458 Bucaneve, Giampaolo, 2041 Chandrasena, Gamini, 2398 Comte, Raymonde, 1803 Debyser, Zeger, 668, 2863 Buckley, Helen R., 1523 Chang, Hernan R., 1803, 2502 Condra, Jon H., 1404 Decaris, Bernard, 1984 Budeanu, Christina, 1501 Chang, Kieyoung, 1794 Condreay, Lynn D., 616 Decazes, Jean M., 195 Buelli, Maurizio, 2041 Chao, Chun C., 2465 Conejo, Maria del Carmen, de Clercq, E., 2180, 2710 Bugnon, Denis, 883 Chapman, Derek G., 2583 1442 De Clercq, Erik, 256, 668, 688, Bult, Auke, 2763 Charoenlarp, P., 511 Conforti, Paul, 184 2863 Burger, David M., 2763 Charpentier, Emmanuelle, 2330 Connell, Edward V., 348 DeCoster, Mark A., 1813 Burger, Richard M., 886 Charter, M., 1356 Cook, Perry, 1363 DeGirolami, P., 345 Burke, Donald, 307 Chavanet, Pascal, 963 Corachan, Manel, 2668 Dekio, S., 2877 Burm, Jin-Pil, 2073 Chavez, Virginia E., 61, 515, Cordova, B. C., 1635 De La Fuente, Ricardo, 2469 Burney, Sibte, 1668 1651 Cordovilla, Pilar, 1314 de Larminat, V., 2780 Burroughs, M., 2111 Chen, Ming, 1339, 1470 Corey, Lawrence, 174 de la Rosa, Mercedes, 337 Burstein, Aaron H., 2024 Chen, Ming S., 2387 Corlett, J., 90 de Lencastre, Herminia, 2590 Burt, Timothy, 1203 Chen, Minjun, 2838 Corneliussen, L., 2047 Del Favero, Albano, 2041 Bush, Karen, 392, 761, 2078, Cheng, Yulin, 2838 Cortopassi, Gino, 2517 de Micco, Philippe, 396, 901 2116, 2150 Cheng, Yung-Chi, 1824 Costerton, J. William, 2803 Dempsey, Maria H., 2270 Butler, Thomas, 2415 Chenon, M. T., 2810 Coulaud, Jean-Michel, 620 den Hollander, Jan G., 931 Butzler, J. P., 2488 Cheron, G., 1209 Coupry, C., 2810 Denning, David W., 1561 Byrne, Ann, 1580 Cheron, Monique, 177 Courvalin, Patrice, 702, 1149, Depardieu, Florence, 1899 Byrne, Mary E., 2238 Cherrier, Pascale, 620 1447, 1675, 1788, 1883, 1899, DeRemer, Mary F., 2689 Byrnes, Vera W., 1404 Cherubin, Charles E., 761 2330, 2925 Derouin, Francis, 2440 Chesa-Jimenez, Jesus, 842 Coustere, C., 1209 DeSante, Karl A., 2134 Cadet De Fontenay, Gerald, Cheung, Lawrence, 223 Coutaux, Anne F., 1419 Desmyter, Jan, 2863 2857 Chin, Nai-Xun, 2615, 2896 Couture, Michele, 742 Desplaces, Nicole, 1149 Caillon, Jocelyne, 883 Chinnaswamy, Jagannath, 170 Couturier, Martine, 2488 Dev, Inderjit K., 1590 Caldwell, Guy A., 648 Chiolero, R., 1309 Craik, Charles S., 2430 DeVore, Kimberly M., 282 Caldwell, John W., 547 Chochola, Jan, 969 Cramp, Rebecca, 767, 991 de Vreese, Karen, 668 Caliendo, Angela M., 282 Choi, Jae H., 905 Crawford, Jack T., 805, 2380 de Vries-Hospers, H. G., 872 Calvo, Rally F., 1651 Chong, Kong-Teck, 288 Cremieux, Anne Claude, 953 de Wilde, G. A., 2180 Cambau, Emmanuelle, 1991 Chopart, P., 1309 Crevoisier, Charles, 2415 Dhib, M., 733 Cameron, Janet, 275 Chopra, Ian, 637 Crowley, James H., 1004 Dholakia, Nizar, 848 Campbell, D. A., 2210 Chou, Ting-Chao, 656 Cruceyra, Antonio, 2183 Dhople, Anita A., 2908 Campillo, Bernard, 340 Chow, Andrew T., 799 Crump, Carolyn E., 66 Dhople, Arvind M., 2908 Camps, Wil, 1922, 1930 Chow, Joseph W., 1152 Crump, C. E., 1425 Diaz, Maria Dolores, 1879 Canadian Haemophilus Study Christensen, S0ren Br0gger, Crumpacker, Clyde S., 307 Diaz, Philip R., 2024 Group, 1678 1339, 1470 Cruz, M. C., 378 Diaz-Mitoma, Francisco, 1157 Cao, Yang, 1620 Chu, Chung K., 2172 Cuesta, F., 632 Diep, To S., 1716 Capobianco, John, 1496 Chu, D. T. W., 1071 Cundy, Kenneth C., 365, 2387 Dietrich, Manfred, 2249 Carbon, C., 1017 Chuard, Christian, 1703 Curnock, S. P., 1205 Dignani, M. Cecilia, 2541 Carbon, Claude, 177, 432, 757, Chung, Raymond, 307 Currie, Bart J., 1203 Di Modugno, Enza, 2362 953, 963 Cid, Dolores, 2469 Currie, Brian, 2029 Ding, Jianping, 1909 Carbonaro, Carol, 1363 Cioffe, C., 2111 Cushman, C. D., 675 Diver, Jonathan M., 1944 Carias, Lenore L., 2663 Cioufu, Oana, 2306 Cynamon, M. H., 234, 1452, Doit, Catherine P., 2655 Carlos, Rita Q., 2024 Civitico, Gilda, 719 1455, 1476, 1721, 2245 Dollenberg, Heidi, 518 Carlson, Petteri, 142 Clancy, Joanna, 2008 Domin, Barbara A., 1590 Carniel, Elisabeth, 481 Clarke, Cyril R., 2392 Dallegri, Franco, 2605 Dominguez-Gil Hurle, A., 2510 Carotenuto, Mario, 2041 Clarkson, Allen B., Jr., 563, Daluge, Susan M., 616, 1590 Donatsch, Peter, 1763 Carrano, Lucia, 1904 2545 Dan, M., 837 Doran, John, 2502 Carrier, Danielle, 742 Clasener, H. A. L., 409 D'Antonio, Domenico, 2041 Dornsife, Ronna E., 868, 1590 Carrillo, Carlos, 558 Clement, Jacob J., 1071 Danziger, Larry H., 170, 876, Dougherty, Thomas J., 205 Carter, Philip E., 1256 Clemmentsen, Inge, 2306 2106 Douglas, C., 1480, 2750 Cartier, Francois, 438 Clemons, Karl V., 460 D'Aquila, Richard T., 282, 656 Dowson, Christopher G., 49 Cartwright, Frank D., 2628 Clewell, Don B., 1152 Dargis, M., 973 Doyle, Laura J., 2194 Carver, Peggy L., 319, 326 Climo, Michael W., 2231 Darkes, Marilyn C., 504 Drach, John C., 2889 VOL. 38, 1994 AUTHOR INDEX iii

Dreikorn, S., 1480, 2750 Fauvelle, Francis, 620, 1519 Fullen, Glenda H., 1644 Gimema Infection Program, Dreyhaupt, T., 1849 Feinberg, Judith, 1190, 1534 Furihata, Kazuo, 2197 The, 2041 Drlica, Karl, 886 Felgner, Jiin, 2792 Furione, Milena, 38 Gips, Marina, 2336 Dropinski, J. F., 2750 Felgner, Phillip L., 2792 Furlong, Stephen T., 2534 Giralt, Ernest, 2477 Drugeon, H. B., 2695 Fennewald, Susan M., 2889 Furman, Phillip A., 616 Girmenia, Corrado, 2041 Drugeon, Henri B., 883 Fernandez, E. J. Quinto, 1655 Furneri, Pio Maria, 2651 Gitterman, S. R., 1726 Drusano, George L., 628, 1386 Fernandez-Baca, Victoria, 1879 Furney, Synthia K., 2557 Giwercman, Birgit, 2306 Drusano, G. L., 1726 Fernandez-Gallardo, L. C., Furuya, Nobuhiko, 528 Glasdorff, N., 2488 Dubois, J., 2276 2798 Fyfe, James A., 1590 Glauser, M. P., 1309, 2683, Dubois, Jacques, 1368 Ferone, Robert, 1590 2846 Dudley, Michael N., 1386, 2351 Ferrari, Livia, 2362 Gluzman, Yakov, 1658 Duffull, S. B., 2480 Ferraro, Mary Jane, 144 Gaillard, J.-L., 1209 Gmunder, Hans, 1966 Duong, Ngyuen M., 1716 Ferraro, M. J., 252 Gal, Peter, 2024 Gobert, Judy M., 861 Dupeyron, Catherine, 340 Feucht, Hubert, 1251 Galama, Joep, 1922, 1930 Goessens, W. H. F., 487 DuPont, Herbert L., 558 Ficari, Ferdinando, 2221 Galassi, Gianluca, 2362 Goh, Khye Seng, 1433, 2287 Dutka-Malen, Sylvie, 1675 Fillastre, J. P., 733 Gallant, Joel, 1534 Gokaslan, Ayse, 2541 Duval, Jean, 432, 1149 Finegold, Sydney M., 2504, Galleni, Moreno, 1608 Goldani, Luciano Z., 371 Duyts, Tineke, 2763 2513 Gallicano, Keith, 894, 2187 Goldberg, Burt, 563 Dworkin, Brad, 2215 Fink, Mitchell P., 547 Gallis, Harry A., 799 Goldberg, Erwin, 275 Dyke, K. G. H., 1205 Firestone, Raymond A., 2633 Galvez, Antonio, 1314, 1820 Goldfarb, Johanna, 315, 2817 Dykstra, Christine C., 1890 Firth, Neville, 2238 Gambertoglio, John G., 260, Goldman, Robert C., 1496 Fish, Douglas N., 876 1190 Goldstein, F. W., 2218 Echevarria, Juan, 558 Fishelevich, R., 675 Gambino, Laura F., 1773 Golin, John, 2492 Echols, Roger M., 547 Fishman, Jay A., 2534 Gangadharam, Pattisapu R. J., Golub, Lorne M., 400 Edelstein, Martha A. C., 200, Flamm, Robert, 392,1496 170 Gomez, Julian, 2668 217 Fletcher, Courtney V., 604 Gao, Qing, 275 Gomez, Maria, 2183 Edelstein, Paul H., 200, 217 Flexner, Charles, 1036 Garber, Gary, 2187 Gong, Yi-Fei, 1683 Edlind, T. D., 378, 2086 Flor, Soledad C., 799 Garcia, Isabel, 2426 Gonli, Pilar, 2477 Edlind, Thomas D., 1834 Flora, Karl P., 1107 Garcia, M. L., 2750 Goodwin, S. Diane, 799 Edwards, John E., Jr., 1460, Fluckiger, U., 2846 Garcia, Silvia, 2469 Gootz, Thomas D., 130 2029 Flynn, Patricia M., 1644 Garcia-Ignacio, Bernadette G., Gordon, V. R., 2086 Eggimann, P., 1309 Flynn, P. M., 115 1651 Gorelick, Kenneth J., 260 Ehrett, Stuart, 83 Fok, Eugene, 2671 Garcia-Ignacio, Bernadette Y., Gorz, Andreas, 13 Eiseman, Julie L., 628 Fontaine, Lise, 750 61, 515 Gosselin, Gilles, 1292, 2172, Eisenach, Kathleen, 2380 Fontana, Roberta, 1980 Gardner, Michael F., 2792 2300 Elbaggari, Ahmed, 1246 Forenza, Salvatore, 2633 Garrett, Kelsey, 518, 1303 Gotfried, Mark H., 876 Elbeik, Tarek, 1246 Forlenza, Susan, 2227 Garrigues, Jean Christophe, Gotlib, Leah, 1404 Elberg, Svetlana, 294, 300 Forrest, Alan, 2024 2857 Goto, Sachiko, 1118 Elhanan, Gai, 2612 Forsgren, Arne, 879 Garry, Louis, 1681 Gotuzzo, Eduardo, 558 Eliopoulos, G., 345 2409 Eliopoulos, George M., 144 Forstall, G. J., 1868 Gary, David, 1534 Goudgaon, Naganna M., 252, 534 Fosberry, Andrew P., 1182 Gascon, Joaquim, 2668 Gouin, Frangois, 901 Eliopoulos, G. M., Fothergill, Annette W., 1530, Gassis, Safwat, 2871 Gould, Ian M., 2583 Ellis, Brian, 2803 2553 Gatermann, S., 2564 Gourde, Pierrette, 189, 742, Ellis, M. Nixon, 616, 2792 Fouet, Paul, 340 Gatti, Giorgio, 260 750, 1555 Ellis, W., 1753, 1862 Fowler, C., 2369 Gaudebout, Claude, 1681 Gourdeau, M., 2276 Ellner, Jerrold J., 1794, 2557 Fowler, David A., 924 Gaudin, Claudie, 243 Gracheck, Stephen J., 1773 Elwell, Lynn P., 1890 Foy, Jilanna, 2572 Gaul, Forrest, 668 Grados, Pablo, 558 Emini, Emilio A., 1404 Frame, Peter T., 1541 Gaus, Wilhelm, 2249 Graham, Donald J., 1404 Endo, Takeshi, 945 Franceschini, Nicola, 1608 Gay, G., 733 Granero, Luis, 842 Endres, Matthias, 1251 Francioli, P., 2846 Gedris, Cheryl, 1363 Graybill, John R., 2676 Ennabli, Karim, 396 Francis, Peter, 518 Geers, A. B. M., 415 Graybill, J. R., 1604 Entenza, J. M., 2683 Francis, Peter A., 713 Geesey, G. G., 2125 Graziani, Amy, 1580 Erbetti, Isabelle, 2362 1808 1628 Franco, Robert J., 886 Gekker, Genya, 2465 Greenstein, Michael, Erickson-Viitanen, Susan, Frank, O., 2458 Gentile, Giuseppe, 2041 Grellier, Philippe, 1144 Eron, Joseph J., 282 Franzblau, Scott G., 61, 515, Gentry, Layne O., 1422 Grenier, Louis, 54, 750, 1027 Eskes, Tom, 1930 1651 Georgakopoulos, Kathleen, Greve, Jeffrey M., 1413 Espersen, F., 2047 Freeman, A., 1356 2785 Griffin, Johanna A., 388 Etienne, I., 733 Freeman, Collin D., 1515, 2449 George, Anthony M., 542 Gross, M. S., 1205 Etzel, Joseph V., 2227 Frei, R., 1309 George, Robert C., 49 Grosset, Jacques, 2521 Fairlamb, Alan H., 1298 Fremaux, Annick J., 2655 Georgopapadakou, N. H., 959 Grosset, Jacques H., 662 Falconi, M., 830 Frere, Jean-Marie, 1608 Gerbaud, Guy, 702, 1883, 2330 Grossi, M. A., 234, 1452, 2245 Falloon, Judith, 1580 Frick, Lloyd W., 2722 Gerna, Giuseppe, 38 Grossie, V. B., Jr., 2224 Fang, Hengsheng, 275 Fricker, Simon P., 504 Geslin, Pierre L., 2655 Gruter, Ludwig, 1251 Fantin, B., 1017 Fridland, A., 115 Ghannoum, Mahmoud A., Gu, Zhengxian, 275 Fantin, Bruno, 432 Fridland, Arnold, 1683 1460, 2029 Guan, Ming Xu, 1157 Faraj, Abdesslem, 924, 2172, Friedland, Ian, 83 Giamarellou, Helen, 2925 Guay, Gordon G., 857 2300 Frimodt-M0ller, N., 2047 Gilbert, Brian E., 356 Guerrero, Carmen, 773 Farino, John, 151 Frontespezi, Stefano, 1416 Gilbert, David N., 2169 Guerrero, Manuel L. Farinoti, Robert, 757 Frost, David J., 1378 Gilbert, Deborah H., 2351 Fernaindez, 1103 Farinotti, Robert, 177 Fuchs, Peter C., 2419 Gilbert, D. N., 1065 Guerrier, Marie-Louise, 824 Fasola, Giampiero, 2041 Fujihara, Masaya, 2665 Gill, Mark A., 151, 2073 Guillevin, Loic, 1519 FaBbender, M., 455 Fujii, Kenji, 1118 Gillis, Thomas P., 1651, 2380 Guimart, C., 733 Fattorini, Lanfranco, 1608 Fujioka, H., 2258 Gilmore, Michael S., 1194 Guito, Kenneth P., 1644 iv AUTHOR INDEX ANTIMICROB. AGENTS CHEMOTHER.

Guiyoule, Annie, 481 Hiestand, Peter, 1763 Inoue, Eiko, 1974 Kahn, James O., 260 Guo, Li, 2483 Higa, Henry, 2200 Irifune, Kenji, 738, 790 Kahn, Marcel-Francis, 243 Gupta, Chhitar M., 588 Higgins, Michael L., 1523 Ishida, Kazuo, 528, 738, 790 Kaiser, Allen B., 1325 Gupta, Haridwari P., 588 Hill, Craig L., 504 Ishii, Takanori, 653 Kaku, Mitsuo, 528, 738, 790, Gurnani, Komal, 742 Hinshaw, Roger R., 288 Ishii, Yoshikazu, 528 2843 Gutmann, Laurent, 195, 824, Hirakata, Yoichi, 528 Islam, Khalid, 1239 Kakuk, Thomas J., 1277 1085 Hirata, Takahiro, 1966 Issah, Abdul, 1363 Kamboji, A., 2530 Guy, Julie, 853 Hirsch, Martin S., 282, 656 Italian Foscarnet Study Group, Kamps, T., 2564 Hirschel, B., 1219 The, 38 Kanai, Kazuo, 2204 Ha, Huynh D., 1716 Hitchcock, Michael J. M., 2387 Ito, Hideaki, 2014 Kanamori, Masato, 353 Hachem, Ray, 2541 Ho, Dah Hsi, 848 Ito, Hideo, 71 Kanazawa, Akihiko, 945 Hackbarth, Corinne J., 2568 Ho, May, 2415 Ittarat, Isra, 1854 Kandpal, Hema, 588 Hacker, Jorg, 681 Ho, Rodney J. Y., 2398 Iwamoto, Kikuo, 2643 Kang, Mohinder S., 1780 Haddad, J., 2210 Hoa, Nguyen T. T., 1716 Iwasaki, Shigeo, 2197 Kang, S. Lena, 2034, 2702 Haggoud, Abdellatif, 1047 Hoban, Daryl J., 1165 Iyobe, Shizuko, 1466 Kanyok, Thomas P., 170 Hague, Christinia M., 2392 Hoban, D. J., 1678 Izumikawa, Kinichi, 790 Kapell, Kathi S., 2213 Hamaguchi, Hiroshi, 2204 Hodgson, J. E., 1205 Jabes, Daniela, 2346 Kaplan, Andrew H., 2929 Hamill, Richard J., 1059 Hodgson, John E., 1182 Jacobs, Michael R., 1794, 2557, Kaplan, Edward L., 1203 Hammer, Scott M., 307 Hoepelman, A. I. M., 415 2902 Kaplan, Joan C., 282 Hammerschlag, Margaret R., Hoeschele, James D., 319 Jacobs, M. R., 211, 369, 898, Kaplan, Sheldon L., 918 1402, 1588, 1873 Hoesterey, Barbara L., 1107 2065, 2317, 2471, 2599, 2905 Karlowsky, James A., 1165 Hammerschmid, Franz, 1763 Hof, Herbert, 1501 Jacobs, William R., 773 Karp, Matti, 2775 Hammond, M. L., 2750 H0iby, Niels, 2306 Jacobson, I., 1356 Karyotakis, Nicholas C., 2541, Hammond, Stephen M., 2362 Holden, J., 252 Jacobson, Mark A., 1190, 1534 2660 Hamzeh, Fayez M., 2404 Holfels, Ellen, 1392 Jacobus, Nilda, 2116 Katiyar, S. K., 2086 Hancock, Robert E. W., 2311 Holgate, Stephen T., 1413 Jacobus, Nilda V., 1808 Kato, Jun-Ichi, 2623 Handwerger, Sandra, 473 Holmes, King K, 1661 Jacopino, Pasquale, 2041 Kato, Nobuo, 71 Hansen, Gale L., 388 Honda, Yoshinobu, 653 Kau, C. L., 1678 238 Jacques-Palaz, Karen, 1915 Hara, Kohei, 738, 790, 2843 Honore, Nadine, Jadhav, P. K., 1635 Kauffman, Carol A., 326, 2495 Harding, Godfrey K M., 1368 Hooper, David C., 1345 Kaye, Keith, 1186 1413 Jaehde, Ulrich, 1129 Harris, Billie J., 79 Hoover-Litty, Helana, Jafari, Hamid S., 83 Kayser, Fritz H., 724 Harris, Jack, 1178 Horii, Toshinobu, 71 Jahne, G., 2710 Keane, Conor T., 2357 Harrison, Christopher J., 2059 Horowitz, Harold, 1363, 2215 Jakeman, Kenneth J., 1864 Keeney, David, 2078 Harrison, Richard, 1763 Hoshino, Kazuki, 2623 Jaksche, Herbert, 1763 Kellam, Paul, 23 Hart, H. C., 415 Hoskins, Stephen L., 2768 Jambou, Ronan, 953 Kelly, S., 1356 Hasegawa, Shiro, 2665 Hosoya, Mitsuaki, 653 Jansen, Robert, 868 Kempf, Dale J., 2929 Haskell, Suzanne L., 130 Hostetler, Karl Y., 2792 Kenny, George E., 2628 G. 79 Jansen, Robert W., 616 Hastings, J., 2827 Hottendorf, H., Jansen, R. W., 2921 Kent, Kenneth M., 2387 Hatcher, Barbara L., 2134 Hou, Li, 2169 Kern, Peter, 465, 681, 2249 2280 Janssen, Marcel A. C., 2863 Hattori, Hiroaki, 1757, 2014 Houghten, Richard A., Janssen, Paul A. J., 2863 Kern, Winfried V., 465, 681 Haverstock, Daniel C., 547 Hromas, Robert A., 576 Japour, Anthony J., 307 Kernodle, Douglas S., 1325, Hay, Birgit, 465 Hsiung, G. D., 1824 Jarlier, Vincent, 1991 1649 Hayakawa, Isao, 2323 Hsu, Ming-Chu, 348 Khan, W. N., 2210 Shari 2785 Jaskunas, S. R., 1997 Hayashi, Hideya, 1107 Hsu, A., Jason, David, 2583 Kharazmi, Arsalan, 1339, 1470 Hayden, F. G., 1425 Hu, Shuxian, 2465 Khardori, Nancy, 134 2896 Jehl, F., 2780 Hayden, Frederick G., 66, 1178 Huang, Hua-Bin, Jhee, Stanford S., 2073 Khosla, Mala, 2871 Hayden, Mary K., 1225 Huang, Wai Mun, 773, 2091 Ji, Baohong, 662, 2521 Khoury, Antoine E., 2803 Hayem, Gilles, 243 Huang, Wanzhi, 2266 Jimenez, Claribel L., 61, 515, Kieff, Elliott, 126 Haynes, M. Page, 1523 Huber, O., 1309 Kieft, H., 415 John 2889 1651 Hazuda, D., 2827 Huffman, H., Jimenez De Anta, Teresa, Kimura, Masashi, 2296 He, Qing, 865 Hughes, Stephen H., 1909 Kimura, Youichi, 2323 Walter 1644 2477, 2668 He, Xiaogang, 2495 Hughes, T., Jin, Y.-F., 422 Kinzig, M., 1849 Heard, Stephen O., 547 Huguenel, Edward, 1413 Kinzig, Martina, 905 C. 675 Joesoef, M. R., 2530 Heath, I. B., 1480 Hunter, J. R., Alan 49 Kirby, Geoffrey C., 96 Heifets, Leonid, 1161, 2738 Hutchin, Tim, 2517 Johnson, P., Kirkwood, Jeffrey A., 2134 1470 Johnson, Frank, 2803 Heijtink, R. A., 2180 Hviid, Lars, Johnson, Lance C., 616 Kirn, Andre, 1292 Heinemann, Murk-Hein, 1190 Hyatt, Judith M., 2730 Kirschner, Philip, 228, 381 David 2134 Johnson, Royce H., 547 Heinemann, Volker, 911 Hyslop, L., Johnston, Sebastian L., 1413 Kiso, Yoshiaki, 1107 Heinzinger, Nina K., 2483 Joiner, Keith A., 1620 Kitagawa, Masayuki, 707 Heisig, Peter, 1284 Ibanez, Maria A., 2908 Jolley, A., 2369 Kitamura, Akihiro, 2623 Helsberg, M., 2710 Ibrahim, Ashraf S., 2029 Joly, Veronique, 177, 963 Kitzes, R., 837 Hendrix, Craig W., 1036 Idajadi, A., 2530 Jones, C. David, 2134 Kitzis, Marie Dominique, 195, Hensey, D., 1071 Idemyor, Vincent, 761 Jones, Clare Edgar, 604 1085 Henson, Geoffrey, 668 Ikeda, Hideo, 2623 Joos, Beda, 1197 Kitzis, M. D., 2218 Henson, Geoffrey W., 504 Ikeda, Satoru, 256 Jorgensen, C., 90 Kivisto, Kari T., 248 Hermsmeyer, K, 1065 Ikeda, Tomiki, 945 Jude, David A., 403 Klabe, Ronald M., 1628 Hernandez, Jesus M., 184 Imada, Takuma, 2340 Jurewicz, Regina, 2454 Klatser, Paul R., 1959 Herrmann, M., 1219 Imbach, Jean-Louis, 1292, Marie 883 Klein, Oscar, 2896 Herter, C., 1309 2172, 2300 Juvin, E., Klein, Robert S., 2572 Herzig, Yaacov, 374 Imtiaz, Uzma, 1134 Kaatz, Glenn W., 2034, 2702 Klemens, S. P., 234, 1452, 1455, Heseltine, Peter N. R., 151 Incavo, Stephen J., 905 Kabha, Kisra, 374 1476, 1721, 2245 Hickey, Sheila M., 1320 Inderlied, Clark B., 1200, 1838, Kagami, Toshihide, 1140 Klopman, Gilles, 1794, 2557 Hien, Tran T., 1716 1844, 2717 Kageyama, Seiji, 1107 Kluyver, M., 415 VOL. 38, 1994 AUTHOR INDEX v

Knapp, C. C., 1868 Landman, David, 385, 1668 Liso, Vincenzo, 2041 Martinez-Bueno, Manuel, 1314, Knapp, Joan S., 155, 1688, Lane, H. Clifford, 1580 Livelo, Jocelyn B., 61, 515, 1820 2194, 2200 Lane, James, 307 1651 Martinez Cabarga, M., 2510 Knapp, J. S., 2530 Larder, Brendan A., 23, 1428 Livermore, David M., 1262, Martinez-Martinez, L., 1439 Knapp, Margaret J., 326 LaRocco, Mark, 2266 1732, 1742 Martinez-Suarez, Joaquin V., Kneebone, Patricia H., 576 LaRocco, Mark T., 1422 Lizak, Patricia, 1190 45 Knoller, Sara, 648 Larsson, Alison J., 2003 Lloyd, Robert M., Jr., 268 Martino, Piero, 2041 Knowles, David, 991 Laufs, Rainer, 1251 Locarnini, Stephen, 719 Mason, Edward O., Jr., 918 Knowles, David J. C., 767 Lauhio, Anneli, 400 Lode, H., 455 Masur, Henry, 1580 Ko, Yuan-Tih, 1378 Lavelle, James, 1580 Lokiec, F., 1209 Matha, V., 1209 Kobayashi, George S., 294, 300 Law, Derek, 1561 Long, William J., 1404 Mathe, Christophe, 2300, 1292, Koch, Michel, 1169 Lawlor, Elizabeth J., 1182 Lopez, Horacio, 1980 2172 Koduri, Raju K., 1507 Layton, Marcelle C., 1664 Lopez-Berestein, Gabriel, 223, Mathes, Lawrence E., 1573 Koenig, Gabriella I., 1225 Le, Quyen-Quyen, 2266 356, 2224 Matson, James A., 2633 Koeppe, P., 455 Lebbadi, Mariam, 1314, 1820 Lorenz, R. Todd, 1004 Matsubara, Kenichi, 707 Koeter, G. H., 872 LeBlanc, Barbara, 848 Lortholary, Olivier, 1519 Matsumoto, Takahiro, 812 Koga, Hironobu, 528, 738, 790, Le Bras, Jacques, 1169 Louchahi, Mohamed, 1519 Matthews-Davis, Nicole, 2743 2843 Leclercq, Roland, 432 Louie, Tom J., 1368 Mauff, Gottfried, 2488 Koga, Kazunori, 812 Lecomte, S., 2810 Lounis, Nacer, 2521 Mayer, Peter, 1763 Koga, Tetsufumi, 138 Le Conte, P., 2695 Low, D. E., 1678 Mayers, Douglas L., 307 Kohlhepp, S. J., 1065 Le Conte, Philippe, 883 Loza, Elena, 122 Mayers, M., 2111 Kohlhepp, Sue J., 2169 Lee, Chao H., 1834 Ludescher, Richard D., 1378 Maziere, Bernard, 432 Kohno, Shigeru, 528, 738, 790, Lee, F. Eun-Hyung, 2404 Ludewig, Gabriele, 1123, 2850 Mazzei, Teresita, 2221 2843 Lee, James, 1303 Lunceford, Jared K., 2577 Mazzoni, Carla, 2221 Koizumi, Fumiaki, 1140 Lee, James W., 518, 713 Luthy, Ruedi, 1197 Mazzulli, Tony, 656 Koks, Cornelis H. W., 2763 Lee, Sunhee, 1507 Lutz, Colleen, 2871 McAuley, James, 1392 Kolenda, H., 1849 Lee, William A., 365, 2387 Lyman, Caron A., 518 McBride, Michael O., 2577 Kolonoski, Peter, 1844, 2717 Leelaporn, Amornrut, 2238 Lyristis, Michael, 1041 McCaffrey, C., 959 Koltin, Yigal, 648 Leemann, T., 1219 McCann, Peter P., 563 Konno, Kimio, 1641 Leeper, Kenneth V., Jr., 547 Ma, Dzwokai, 1742 McClements, W., 2827 Kontiainen, Sirkka, 142 Leet, John E., 2633 Mabry, Thomas E., 2134 McClernon, Daniel R., 1890 Konttinen, Yrjo T., 400 Le Gallou, F., 2695 MacGregor, Rob Roy, 1580 McCracken, George H., Jr., 83, Korba, Brent E., 2172 Legnani, Maria Cristina, 1416 Mack, Douglas, 1392 1320 Kornbluth, Richard S., 2910 Lehan, Malcolm, 403 Mackenzie, Andrew M. R., McDaniel, D., 1071 Korten, Volkan, 611, 2091 Lehto, Pasi, 248 1157 McDonald, C., 115 Koszalka, George W., 868 Leitch, Gordon J., 865 MacKenzie, Fiona M., 2583 McFadden, D. C., 1397 Kovacs, Joseph A., 1580 Leiza, Marina Gonzalez, 2150 Madu, A., 2111 McFarland, Margaret M., 1271 Kovnar, Susanne Gidan, 1644 Leleu, Ghislaine, 195 Maesaki, Shigefumi, 2843 McGeer, A., 1678 Kreiswirth, Barry, 773 Leluan, Georges, 340 Maggiolo, Franco, 1416 McGough, Deanna A., 1530, Krenitsky, Thomas A., 1590 Lemon, Eloise, 2817 Maguinia, Ciro, 558 2553 Kresta, Anne, 2671 Leon, Anne, 1519 Mahut, B., 1209 McGrath, Betty J., 2034, 2702 Kretschmar, Marianne, 1501 Leonard, Peter J., 2492 Maier, Frieder, 1331 McGreevy, P., 1753, 1862 Krishnan, C., 2121 Leone, Anna, 1864 Maiese, William M., 1808 McGuirk, Paul R., 130, 2008 Krogstad, Paul, 2929 Lemer, Stephen A., 641, 1134 Mainardi, J. L., 1017 McKenna, Philip M., 2409 Kruining, J., 2180 Le Roux, Y., 733 Malaure, Helene, 2452 McLaughlin, G. L., 2086 Kuah, B. G., 2502 Leshem, Yoshua, 1176 Malcolm, S. K., 1997 McLeod, Gavin X., 307 Kuijper, Ed J., 1211 Lessard, Celine, 742, 1555 Mallet, Marie-Noelle, 396, 901 McLeod, Rima, 1392 Kukla, Michael J., 2863 Lessley, Bruce A., 2392 Malouin, F., 973 McLinn, Samuel E., 315 Kulka, M., 675 Letting, Dorcas J., 2689 Mamber, Stephen W., 2633 McManus, 0. B., 2750 Kumarasinghe, G., 2502 Levacher, Maryse, 243 Manavathu, Elias K., 1134 McMurry, Laura M., 542 Kuppermann, Baruch D., 1190 Levis, J., 675 Mandala, S., 2750 McPherson, Sylvia, 2300 Kurata, Satoshi, 353 Levy, Jack, 2488 Mangeney, Nicole, 340 Meade, R. P., 1635 Kureishi, Amar, 1944 Levy, Stuart B., 542 Manousos, Mary, 2008 Medeiros, Antone A., 2351 Kurtz, M. B., 1480, 2750 Lew, D., 1309 Maqueda, Mercedes, 1314, Medina, Daniel J., 1824 Kuwahara, Steven, 1036 Lew, Daniel P., 1703 1820 Meek, James L., 1628 Kuyvenhoven, J., 487 Lew, D. P., 1219 Marche, Claudie, 1681 Meenhorst, Pieter L., 2763 Lewis, Arthur F., 2889 Marco, Francesc, 2477, 2668 Meier, Albrecht, 228, 381 Labrecque, Gaston, 54 Lewis, Deborah A., 1590 Mariano, Noriel, 392 Meisner, D., 1397 Labro, Marie-Therese, 1548 Lewis, J., 2827 Markova, Boika, 981 Melchers, Willem, 1922, 1930 Lacaille, F., 1209 Li, Ju-Yun, 1794 Marre, Reinhard, 465, 681 Melissen, Pernella M. B., 147 Lacey, Simon F., 1428 Li, Xian-Zhi, 1732, 1742 Marrinan, J., 1480, 2750 Mellors, John W., 2409 Lacy, Steven A., 2387 Li, Yi, 1123 Marshall, A. J., 422 Mempel, Martin, 1251 Lagace, J., 1090 Li, Zhen-Hong, 2387 Marshall, Dana R., 1683 Mendel, Dirk B., 2387 Lagente, Michel, 2857 Liberator, P. A., 1397 Marshall, Sarah J., 96 Menichetti, Francesco, 2041 Lahdevirta, Juhani, 400 Lietman, Paul S., 1036, 2404 Marshall, Steven H., 693 Mentis, Andreas F., 2207 Lam, Kan, 2803 Lifson, Jeffrey D., 260 Martel, Alain, 1368 Mercure, Louis, 986 Lam, P. Y. S., 1635 Ligozzi, Marco, 1980 Martellucci, Stephen A., 504 Merrill, Debra P., 656 Lambe, Catherine U., 2722 Lin, Chin-Chung, 2758 Martin, Claude, 396, 901 Meshnick, Steven R., 1854 Lambert, J., 1356 Lin, Lesheng, 54, 742 Martin, Edith, 13, 1331 Meuwissen, Joep, 1922, 1930 Lambert, Thierry, 702, 1883, Linas, Marie Denise, 2857 Martin, J. Louise, 2743 Meyer, Kenneth S., 392 2925 Linnan, M., 2530 Martin, Louis N., 1277 Meyers, Wayne M., 2249 Lamothe, F., 2276 Linss, Werner, 1501 Martin, Robin A., 1490 Meylan, Pascal R. A., 2910 Land, R. A., 1065 Liotta, Dennis C., 2172 Martinez-Beltran, Jesus, 2150 Mezo, Nancy, 2738 vi AUTHOR INDEX ANTIMICROB. AGENTS CHEMOTHER.

Mghir, Azzam Saleh, 953 Moskal, Michael, 315 Nosari, Anna Maria, 2041 Patterson, Jan Evans, 1664 Mian, U., 2111 Mouton, Johan W., 931 Nosbisch, Connie, 781, 787 Pauwels, Rudi, 668, 2863 Michel, M. F., 487 Moynihan, Melinda S., 130 Novak, Paul, 1590 Payne, David J., 767, 991, 1182 Michelet, Christian, 438 Mtairag, El Mostafa, 1548 Novelli, Andrea, 2221 Pearson, Anthony J., 1794 Miick, Cathleen, 2568 Mueller, Bruce A., 2101 Nukaga, Michiyoshi, 1374 Pechere, Jean-Claude, 1803 Mikami, Yuzuru, 2197 Muffat-Joly, Martine, 953 O'Brien, William J., 853 Pecoraro, Vincent L., 319 Miles, R. S., 2143 Mukai, Fumie, 2340 O'Donnell, Alice M., 2689 Pederzoli, P., 830 Milhous, Wilbur K., 1392 Mukantabana, Veronique, 1647 O'Donnell, James J., 1190 Pefanis, A., 252 Milla, Paola, 1904 Mukherjee, Jean, 580, 1507 Oethinger, Margret, 681 Peichl, Peter, 668, 1763 Miller, Lincoln P., 805 Mukherjee, Sushovita, 1507 Ofek, Itzhak, 374 Pendland, Susan L., 2106 Miller, M., 2111 Mukherji, Elora, 1573 Ogata, Masanori, 812 Penn, Charles R., 2270 Miller, Paul F., 1773 Mulder, Jan W., 2763 Ogata-Arakaki, Debra, 1580 Pennington, T. Hugh, 1256 Miller, P. S., 675 Muller-Serieys, C., 2780 O'Hanley, P., 2530 Pennypacker, Susan, 1036 Miller, R., 1753 Munera, M. I., 632 Ohguro, Kinue, 2340 Perani, Evelyn G., 662 Miller, Richard L., 2059 Mufioz, Patricia, 1879 Ohkura, Hisanao, 428 Percivalle, Elena, 38 Miller, Wayne H., 1230 Muratani, Tetsuro, 1466 Ohlin, Ann, 1413 Perea, E. J., 1439 Millerioux, Valerie, 1144 Murphey-Corb, Michael, 1277 Ohmori, Kazunori, 2340 Perea, Evelio J., 1442, 2426 Milligan, J., 2750 Murray, Barbara E., 611, 1915, Ohnishi, Akihiro, 1140 Pereira, Conrad M., 781, 787 Mills, John, 1246 2091 Ohnishi, Sun-Ichi, 2373 Perez, Hilda A., 337 Mitaku, Sofia, 1169 Ohta, Michio, 71 Perez-Diaz, Jose C., 2150 Mitsuhashi, Susumu, 594, 1466, Naas, Thierry, 104, 1262 Ohye, Roy, 2200 Peris, Jos6 Esteban, 842 1974 Nafziger, Anne N., 499 Okamoto, Mark P., 151 Periti, Piero, 2221 Mitsuya, Hiroaki, 1107 Nagahata, Takemitsu, 707 Okazaki, Yoshimasa, 1757 Perrin, Philippe, 620 Mittelman, M. W., 2125 Nakada, Naoki, 1966 Okubo, Shuichi, 1140 Perron, Sylvie, 750 Mittler, E. Stewart, 2785 Nakahiro, Randall K., 151 Oliveras, Linda, 2187 Pershing, L. K, 90 Miyasaka, Tadashi, 688 Nakamura, Shinichi, 1757, 2014 Olliaro, Piero, 2346 Pesce, Amadeo J., 1541 Miyashita, Naoyuki, 2296 Nakata, Katsuhisa, 1757 Olsen, Kurt D., 83, 1320 Petersen, Peter J., 1808 Miyazaki, Shuichi, 1118 Nassar, Faris, 2158, 2162 O'Morain, Colm A., 2357 Peterson, Phillip K., 2465 Mizukane, Ryusuke, 528, 738, Nathan, Henry C., 563 Omri, A., 1090 Petinom, Corinne, 662 790 Nau, R., 1849 O'Neal, Patricia L., 1628 Petit, Patrice X., 243 Mobarakai, Neville, 385 Nau, Roland, 1186 O'Neill, P., 2369 Petitjean, Olivier, 620, 1519 Mobashery, Shahriar, 641, 1134 Navarro, Eileen E., 713 Onishi, J., 1480, 2750 Petitpas, Joan, 2008 Moellering, R. C., 534 Navarro, Ferran, 1788 Onyeji, Cyprian O., 523, 1112 Petrofsky, Mary, 2717 Moellering, R. C., Jr., 252 N'Deli, Laurent, 662 Oppegaard, Hanne, 2460 Pfaller, Michael A., 2419 Moellering, Robert C., Jr., 144 Neal, Sandra W., 2194, 2200 Opravil, Milos, 1197 Pfefferkorn, E. R., 31 Moguilevsky, Nicole, 969 Neale, Jane, 991 Oratore, Arduino, 1608 Phan, Lienhanh, 1246 Mohan, Prem, 256 Negri, Maria Cristina, 122 Orefici, Graziella, 1608 Phaneuf, Denis, 986 Mohler, J., 1017 Nelson, Donald J., 1230, 2722 Orme, Ian M., 2557 Philipp, Wolfgang, 773 Moine, Pierre, 1953 Neu, Harold C., 2615, 2896 Ortega, M. C., 1439 Phillips, Ian, 494 Mojaverian, Parviz, 2758 Neyts, J., 2710 Osano, Etsuo, 71 Phillipson, J. David, 96 Molinari, M., 872 Neyts, Johan, 256 Oseko, Fumimaro, 2643 Picazo, Juan J., 2183 Molitoris, Eric, 2504, 2513 Ng, Eva Y. W., 1345 Ossi, Michael J., 315 Piddock, Laura J. V., 163, 422 Monath, Thomas P., 2785 Nguyen, Hieu, 134 Otero, J. L. Rodriguez, 1655 Pieringer, Ronald A., 1523 Montalban, Gloria, 1402, 1588 Nguyen, M. Hong, 2409 Ottaviani, Michele, 432 Piers, Kevin L., 2311 Montay, G., 733 Ni, Lan, 504 Otter, Brian A., 2572 Pinder, Philip E., 403 Montecalvo, Marisa A., 1363 Nichols, Wright W., 403 Ownby, Kristin, 1580 Piot, Peter, 1647 Monteil, H., 2780 Nichterlein, Thomas, 1501 Piriz, Segundo, 2469 Montillo, Marco, 2041 Nicolau, David P., 523, 1112, Packer, Richard R., 2419 Piscitelli, Stephen C., 1303, Montplaisir, S., 1090 1515, 2449 Padmanabhan, Sreenivasan, 2106 Moody, Kathleen D., 1567 Nicoletti, Giuseppe, 2651 668 Pitt, William G., 2577 Mooney, John J., 1419 Nicolle, Lindsay E., 1368 Paessens, Arno, 1413 Pittet, D., 1309 Moonis, Mona, 656 Niederman, Michael S., 547 Paff, Melanie T., 616, 1230 Pivamik, Phil, 2351 Moore, Caroline B., 1561 Niemeyer, Debra M., 447 Pagano, Paul J., 288 Pizzo, P. A., 1726 Moore, Carol Wood, 1615 Niga, Toshiyuki, 2014 Painter, George R., 616 Pizzo, Philip A., 518, 713, 1303, Moore, Matthew R., 2404 Nightingale, Charles H., 523, Pakuts, Attila, 894 2883 Moore, T. C., 1678 1112, 1515, 2449 Palzkill, Timothy, 2266 Place, Gary D., 2134 Mor, Natan, 1161, 2738 Nikaido, Hiroshi, 1732, 1742 Pang, Y., 1408 Ploy, Marie-Cecile, 2925 Moran, J. S., 2530 Niki, Yoshihito, 2296 Pankuch, G. A., 369, 2065, Po, Alain Li Wan, 1271 Moreau, N. J., 2810 Nishiyama, Satoshi, 2665 2317, 2905 Poch, F., 837 Moreillon, P., 2683, 2846 Niwano, Yoshimi, 2204 Papazian, Laurent, 901 Pocidalo, Jean-Jacques, 243, Moreno, Asuncion, 2668 Nix, David E., 2730 Para, Michael F., 604 432, 953, 1681, 1953 Moreno, Francisco, 2676 Noda, Takeshi, 428 Parekh, Manhar C., 2194, 2200 Poest-Clement, E., 415 Morgan, Amy, 1580 Nolan, Charles M., 2380 Paris, Maria M., 1320 Polak, Annemarie, 1803 Morice, Natchez, 889 Nollstadt, K., 2750 Parker, Anita C., 1711 Polianski, Juliette, 1681 Morikawa, Keiko, 2643 Nollstadt, K. H., 2258 Parks, Leo W., 1004 Polis, Michael, 1580 Morikawa, Shigeru, 2643 Norbeck, Daniel W., 2929 Parniak, Michael A., 275 Polsky, Bruce, 1190 Morisaki, Naoko, 2197 Norbiato, Guido, 2605 Parr, Thomas R., Jr., 937 Ponticello, G., 2827 Morita, Koji, 353 Nord, C. E., 455 Parras, Francisco, 83 Pop, Emil, 817 Morosini, Maria Isabel, 122 Nordmann, Patrice, 104, 1262 Parrilla, Manuela Luisa R., 61, Portaels, Franscoise, 2380 Morris, R., 1205 Nordstr6m, Dan, 400 515, 1651 Portmann, R., 1219 Morrissey, Ian, 2623 Norgard, Michael V., 330 Parry, Nigel R., 868, 1590 Potel, G., 2695 Morrow, Casey D., 2300 Norris, Steven R., 1649 Pascual, Alvaro, 2426 Potel, Gilles, 883 Morse, Gene D., 2689 North, Thomas W., 388, 861 Paton, R., 2143 Poupart, Marie-Christine, 2452 VOL. 38, 1994 AUTHOR INDEX vii

Powdrill, Thomas F., 616 Revankar, Ganapathi R., 2889 Ru, Y., 1635 Scheidegger, C., 1309 Powles, M. A., 1397, 2258 Revel, Valerie, 1991 Rubinstein, Ethan, 374, 757 Schentag, Jerome J., 547, 2730 Prange, H. W., 1849 Revello, M. Grazia, 38 Ruiz, Joaquim, 2477 Schepers, Peter, 1959 Pravettoni, Grazia, 1416 Reynolds, Peter E., 1899 Ruiz-Santa-Quiteria, Jose Schievink-de Vries, W., 360 Precious, E., 1356 Reysset, Gilles, 1047 Antonio, 2469 Schiff, Paul L., Jr., 96 Preston, M. A., 2121 Rhame, Frank S., 604 Runck, Jennifer, 2572 Schildberg, F. W., 2564 Price, Margaret F., 1422 Rhodes, Audrey, 1404 Rusconi, Stefano, 656 Schinazi, Raymond F., 268, Prins, Jan M., 1211 Riber, U., 2047 Rush, Joanne, 1246 504, 1292, 2172, 2300, 2409 Prus, Karen L., 1230 Ricci, John, 2792 Russel, Frans, 1922 Schiphuis, J., 360 Ptak, Roger G., 2889 Ricci, Paolo, 2041 Russell, Peter F., 96 Schiro, Denise D., 889 Pu, Yu-Ming, 1854 Rice, Louis B., 693, 2663 Russell, Stuart, 1864 Schlabach, Abner J., 1404 Pucci, Michael J., 205, 447 Rice, Roselyn J., 155, 1688, Ruwart, Mary J., 1277 Schleif, William A., 1404 Puister, S. M. T., 872 2194, 2200 RV43 Study Group, the, 307 Schmal-Bauer, W. C., 487 Pukrittayakamee, S., 511 Richardson, James D., 1859 Ryan, D. Michael, 2270 Schmatz, D. M., 1397, 2258 Puleo, Catherine, 499 Richman, Douglas D., 348, Rybak, Michael J., 2034, 2702 Schneider, Christine L., 1404 Pulverer, Gerhard, 2488 2792, 2910 Ryffel, Cristina, 724 Schollaardt, Tineke, 1944 Purifoy, Dorothy J. M., 1590 Ricou, B., 1309 Schols, Dominique, 2863 Qian, Mingxin, 2398 Rider, Joan M., 326 Sachdeva, Meena, 1186 Schoondermark-Van de Ven, Quale, John M., 385, 1668 Riesbeck, Kristian, 879 Saez, A. Cepeda, 1655 Esther, 1922, 1930 Quassem, C., 837 Rigaud, Daniel, 963 Saez-Llorens, Xavier, 83 Schopfer, Lawrence M., 2483 Queener, Sherry F., 1834, 1859 Rigomier, Daniel, 1144 Safrin, Sharon, 1246 Schott, D., 733 Quesniaux, Valerie, 1763 Riley, G., 2121 Sagers, Richard D., 2577 Schouten, Diana, 2671 Quintero, Julio C., 1404 Rinaldi, Michael G., 1303, Sahai, Jan, 894, 2187 Schreckenberger, Paul C., 2106 Quintiliani, Richard, 523, 1112, 1530, 2553 Sahm, Daniel F., 1194 Schrenzel, J., 1219 1515, 2449 Rinderknecht, Steven, 83 Said, Rachid, 396 Schrevel, Joseph, 1144 Quinting, Birgit, 1608 Ritchie, John A., 2029 Saint-Julien, Line, 177 Schukkink, Rianne A. F., 1959 Rittenhouse, S. F., 2317 Saint-Pierre-Chazalet, Michele, Schumacher, Helga, 2306 Radding, Jeffrey A., 937 Ritz, M., 455 1079 Schunack, Walter, 1129 Radolf, Justin D., 330 Robbins, B. L., 115 Saito, Daizo, 428 Schuster, B. G., 1753, 1862 Radwanski, Elaine, 2758 Roberson, Paula K, 1644 Saito, H., 2877 Schutze, Gordon E., 918 Radzilowski, E., 2827 Roberts, Chester R., 307 Sakai, Noritaka, 1641 Schuurman, Henk-Jan, 1763 Raghavan, Krishnaswamy, 817 Roberts, E. Donald, 1277 Sakamoto, Tomoko, 2197 Schwab, J. Conrad, 1620 Rahal, James J., 392 Roberts, Grace B., 1590 Salazar, Leiria, 773 Schwartz, E., 2111 Rahman, Mahbubur, 2488 Roberts, Marilyn C., 1661 Salfinger, Max, 2380 Schwartz, Richard, 315 Rahmani, Rita, 374 Roberts, M. C., 1408 Salhany, James M., 2483 Schwartz, Stefan, 911 Rakita, Robert M., 1915 Robinson, Dana, 1246 Salibian, Mossi, 371 Schwebke, Jane R., 1661 Ramanathan, Chandra S., 268 Robinson, Tonya, 2883 Salo, Tuula, 400 Scott, Eileen M., 1271 Rambout, Lisa, 2187 Roblas, Ricardo Fernandez, Salomon, Horacio, 275 Scriver, S. R., 1678 Ramer, N., 1071 1103 Saltzman, Robin, 2454 Sebald, Madeleine, 1047 Ramirez, Encarnaci6n, 1442 Roblin, Patricia M., 1402, 1588 Sambuy, Yula, 1239 Sedeijo, J., 2798 Ramon, Jacob, 757 Rodman, J., 115 Samia, Julie A., 2534 Sedrati, Lyria, 340 Ramos, Herlinda, 1079 Rodriguez, L. Dominguez, 1655 Samonis, G., 602 Segreti, John, 2213 Ranaldi, Giulia, 1239 Rodriguez-Creixems, Marta, Sampayo, C. Fente, 1655 Seguela, Jean Paul, 2857 Rando, Robert F., 2889 1879 Sanchez, Ana, 2183 Sein, Tin, 2883 Ransom, J. Laurence, 2024 Rodriguez-Tudela, Juan L., 45 Sanchez, Jorge, 558 Sekiya, Kouichi, 688 Rasmussen, Beth A., 392, 761, Rodvold, Keith A., 876 Sanchez, Rosario, 1879 Sekiya, Takao, 428 1658, 2078, 2116 Rogge, M. C., 1476, 2369 Sanchez Navarro, A., 2510 Self, Pamela, 315 Rasmussen, Jan W., 2306 Roilides, Emmanuel, 2883 Sande, Eric R., 1186 Selleseth, Dean W., 616, 2792 Rastogi, Nalin, 1433, 2287 Rolston, Kenneth, 134, 624 Sanders, Christine C., 2095 Selnick, H., 2827 Rathod, Pradipsinh K, 476, Rolston, Kenneth V. I., 848 Sanders, Theodore W., Jr., 79 Selvarajan, Rita M., 853 2492, 2871 Romero, Jose, 2183 Sanderson, Gwen, 1413 Seo, Akira, 2204 Rau, H. G., 2564 Ronchetti, Peter J., 905 Sangeorzan, Jon A., 2495 Seo, Susan M., 2702 Ravelomanantsoa, Nicole, 1169 Rood, Julian I., 1041 Sarasini, Antonella, 38 Serra, Antonio, 2917 Rayner, M. M., 1635 Roper, Elise, 2238 Sardana, Vinod V., 1404 Severe Pneumonia Study Raz, Raul, 1176, 2612 Roper, Randall J., 2577 Sarfati, Claudine, 2440 Group, the, 547 Reardon, John E., 1590, 2743 Ros, Maria Jesus, 2917 Saric, Muhamed, 2545 Severien, Carlos, 83 Reddy, M. Venkata, 170 Rosdahl, V. Thamdrup, 2047 Saric, Muhammed, 563 Shah, Vijay, 2227 Reed, Michael D., 2817 Rose, Richard M., 2534 Sato, K., 2877 Shannon, Kevin, 494 Reeves, Denise, 2504 Rosenbaum, Beverly, 134 Sato, Kenichi, 2623 Sharkawi, M., 1090 Reichman, Richard, 307 Rosenblum, Michael G., 223 Satta, Giuseppe, 1980 Sharma, Sunaina, 1490 Reid, Gregor, 1490 Rosenwirth, Brigitte, 668, 1763 Sauer, Dean F., 1507 Sharpe, C. A., 1476 Reilly, J., 2210 Rosing, Hilde, 2763 Saux, Pierre, 901 Shaw, Jeng-Pyng, 365 Reina, Jordi, 2917 Rosner, Judah L., 1829 Savina, Paul M., 1590 Shaw, Margaret M., 1834, 1859 Reinhard, Mary K, 79 Rossan, R., 1753 Sawai, Tetsuo, 1374 Shaw, Tim, 719 Reinhart, Harald H., 547 Rossi, Rosaria, 2346 Scavizzi, Maurice R., 481 Shek, Pang N., 2671 Reist, Elmer J., 2165 Roth, Elizabeth, 1404 Schaad, Heinz J., 1703 Shelton, Sharon, 1320 Remington, J. S., 570 Rothstein, David M., 857 Schaad, U., 1309 Shenep, Jerry L., 1644 Remington, Kathryn Martin, Rotschafer, John C., 2003 Schaefer, Peter, 2227 Shi, Chaofu, 2409 861 Rotstein, Ori D., 2671 Schalm, S. W., 2180 Shigematsu, Akio, 812 Remington, Michael, 174 Rottensterich, Elimelech, 1176 Schardey, H. M., 2564 Shigeta, Shiro, 653, 688 Renkonen, Olli-Veikko, 142 Rouse, Mark S., 2191 Scharff, Matthew D., 580, 1507, Shih, Cheng-Kon, 388 Reshmi, Shalini, 476 Roy, Anindya K., 319 1695 Shimosato, Yukio, 428 Restrepo, M., 632 Rozenberg-Arska, M., 415 Schatz, Franz, 1763 Shinnick, Thomas M., 805 viii AUTHOR INDEX ANTIMICROB. AGENTS CHEMOTHER.

Shirtliff, Mark E., 2768 Steinberg, Deborah A., 1808 Taylor, Lester C., 2722 Uchida, Katsuhisa, 2204 Shlaes, David M., 2663 Steingrube, V. A., 1408 Tebben, A., 2827 Ueno, Yoshio, 2197 Shyu, W. C., 2210 Steingrube, Vincent A., 381 Telenti, Amalio, 773 Unadkat, Jashvant D., 781, 787, Siami, Ghodrat A., 547 Stephan, Ulrich, 1129 Tello, Waldina Martinez, 1647 2398 Siegert, Wolfgang, 911 Stephens, L. Clifton, 2541 Tempera, Gianna, 2651 Unal, S., 345 Silanos, Maria Antonietta, 1416 Stevens, David A., 460, 2158, ten Napel, Chris H. H., 2763 Upshon, Pauline A., 1937 Silly, C., 1209 2162 Tenover, Fred C., 1363 Urban, Carl, 392 Simard, Marie, 54, 189, 742, Stevenson, Mario, 2483 Terziivanov, Dimiter, 981 Uscher, Maria I., 1320 1027 Stewart, Philip S., 1052 Thain, John L., 403 U.S. Food Drug Sinave, Christian P., 1368 Sticht-Groh, V., 2380 Thaisrivongs, Suvit, 1277 Administration, 908 Singh, Maya P., 1808 St. John, Lisa, 2722 Thal, Lee Ann, 1152 Usui, Toshiaki, 738, 790 Singh, Nepal B., 588 Stoeckel, Klaus, 2415 Thanassi, Jane A., 447 Siregar, J. Joyce, 641 Storz, Gisela, 1829 Thauvin-Eliopoulos, C., 252 Vaara, Martti, 2498 Sirot, Danielle, 1085, 2452 Stragand, Linda, 499 Theander, Thor G., 1339, 1470 Vaara, Timo, 2498 Sirot, Jacques, 2452 Strassle, Anni, 724 Then, Rudolf L., 1803 Vadas, E. B., 1397 Sissia, Genevieve, 2655 Stratton, Charles W., 1649 Theobald, Brian R. C., 504 Vadillo, Santiago, 2469 Sjoerdsma, Albert, 563 Strayer, Andy H., 2351 Theriault, Guy, 750 Vago, Tarcisio, 2605 Skaltsounis, Alexios-Leandros, Stretcher, Brian N., 1541 Thibault, Nathalie, 1027 Valdivia, Eva, 1314, 1820 1169 Strosberg, A. Donny, 969 Thijs, J. C., 360 Valentin, Alexis, 1144 Skerlj, Renato, 668 Struillou, L., 2695 Thompson, J., 487, 2750 Valero, Gustavo, 2676 Skinh0j, P., 2047 Struyvenberg, A., 415 Thomson, Kenneth S., 2095 Valle, Jorge, 2469 Skinner, Pamela S., 2557 Stiuben, Annette, 13 Thornton, David, 668 Vallee, Eric, 1953 Skurray, Ronald A., 2238 Suarez, A. I., 1439 Tiballi, Robert N., 2495 Vallois, Jean Marie, 195, 432 Slifer, T., 570 Suarez, Ana Isabel, 1442 Ticehurst, Julia, 2270 Valverde, E., 2798 Slowik, Mark R., 1620 Subashi, Timothy, 2008 Tidwell, Richard R., 1890 van Altena, R., 872 Smee, Donald F., 2165, 2387 Sucari, Adriana, 1980 Tieszer, Christina, 1490 van Beugen, L., 415 Smet, Hilde, 1647 Suci, P. A., 2125 Tillequin, Francois, 1169 Vandel, Laurence, 1262 Smiley, M. Lynn, 1534 Sugano, Kokichi, 428 Tin-U, Caesar K., 2541 Vanderkolk, Julie, 1161, 2738 Smith, C. C., 675 Sugar, Alan M., 371 Tisdale, Margaret, 868, 1864 van der Vliet, Gabrielle M. E., Smith, C. Jeffrey, 1711 Sugiyama, Stephan T., 2165 Titus, Donna L., 1404 1959 Smith, G., 2827 Sulavik, Mark C., 1773 Tiwari, M., 2415 van Deventer, Sander J. H., Smith, G. M., 608 Sullam, Paul M., 1460 Tod, Michel, 620, 1519 1211 Smith, James W., 1834, 1859 Summers, William C., 2175 Tokue, Yutaka, 428 Vandewiele, Dominique, 1984 Smith, Jeffrey L., 2387 Sundberg, Richard J., 2572 Tom, Peggy, 853 van Draanen, Nanine A., 868 Smith, Michael D., 1716 Sundblad, Kimberly, 576 Tomassini, J., 2827 Van Dyck, Eddy, 1647 Snaith, Hilary A., 1899 Sunkara, Prasad S., 1780 Tomasz, Alexander, 2590 van Gemen, Bob, 1959 Snijder, J. A. M., 360 Susani, Markus, 1172 Tomayko, John F., 611 van Vianen, Wim, 147 Snoeck, R., 2710 Suter, Fredy, 1416 Tomioka, H., 2877 van Zwet, A. A., 360 Snydman, David R., 547 Suter, P., 1309 Tomono, Kazunori, 738, 790 Varma, T. R. K., 1356 Soback, Stefan, 2336 Suyama, Naoyuki, 738, 790 Tonelli, Francesco, 2221 Vartivarian, Shahe, 624 Soejima, Rinzo, 2296 Suzuki, Hitoshi, 653 Tong, William, 1190 Vasquez, J., 632 Soike, Kenneth F., 1277 Swanstrom, Ronald, 2929 Torres-Molina, Francisca, 842 Vaudaux, Pierre, 1703 Sommadossi, Jean-Pierre, 924, Sweet, Clive, 1864 Tortella, Frank C., 1813 Verdejo, Carlos, 1103 1292, 2172, 2300, 2889 Sylvester, D. R., 1205 Traber, Rene, 1763 Verdon, Renaud, 1681 Sorgel, F., 1849 Szebeni, Janos, 1036 Travis, Sharon J., 294 Verhoef, J., 415 Sorgel, Fritz, 905, 1129 Treanor, John J., 1178 Verma, Sandeep, 256 Soriano, Francisco, 1103 Tabenkin, Hava, 1176, 2612 Trenholme, Gordon M., 1225 Vertut-Doi, Aline, 2373 Sorsa, Timo, 400 Tagaya, Etsuko, 1641 Tricot, Guido, 576 Vesentini, S., 830 S0rum, Henning, 2460 Tait-Kamradt, Amelia, 2008 Trieff, Norman M., 2768 Vessels, Jenny M., 937 Sougakoff, Wladimir, 1262, Takahashi, Ema, 2280 Trucksis, Michele, 1345 Vidmar, Thomas J., 1277 1991 Takashima, Hideaki, 688 Truffot-Pernot, Chantal, 2521 Vila, Jordi, 2477, 2668 Spangler, Sheila K., 2902 Takemura, Hiromu, 738, 790 Tsai, Ching-Hwa, 1824 Viola, Franca, 1904 Spangler, S. K., 211, 898, 2471, Takemura, Hisashi, 1140 Tsai, Y., 2210 Viravan, C., 511 2599 Takiff, Howard E., 773 Tschesche, Harald, 400 Virta, Marko, 2775 Speelman, Peter, 1211 Tallan, Barbara M., 2191 Tschorny, Regina, 1284 Viviand, Xavier, 396 Spellberg, Brad J., 2029 Tally, Francis P., 1658 Tselentis, Y., 602 Vivier, N., 733 Spitzer, Eric D., 2029 Tamaoka, Hisashi, 2340 Ts'O, P. 0. P., 675 Vogel, Ulrich, 228 Sprigg, Helen, 624 Tamaoki, Jun, 1641 Tsoukas, Christos, 986 Vojtko, C., 1071 Springer, Burkhardt, 381 Tamarkin, Dove, 374 Tsuji, Akiyoshi, 1118 Volff, Jean-Nicolas, 1984 Squires, Leslie, 1534 Tan, Tina Q., 918 Tsukamoto, Kikuo, 1374 Vollaard, E. J., 409 Sramek, Hilda A., 2054 Tanaka, Hiromichi, 688 Tsutomi, Yumi, 2323 Voorn, G. P., 487 Sridhar, C. N., 2792 Tanaka, Hironori, 738, 790 Tuckman, Margareta, 857 Voskuil, J. H., 415 Srinivas, Ranga V., 1683 Tanaka, S. K., 1071 Tung, Peter P., 2175 Vree, Tom, 1922 Srinivas, R. V., 115 Tanaka, Teruji, 1140 Tunkel, Allan R., 1178 Vuorinen, Pauli, 2775 Staben, Chuck, 1123, 2850 Tang, Julia, 937 Tuomanen, E., 2111 Wacharotayankun, Rochaporn, Stamler, David A., 217 Tankovic, Jacques, 1149 Turgeon, P., 2276 71 Standiford, Harold C., 628 Taras, Alberto, 1416 Turgeon, V., 2276 Wagner, Kenneth F., 307 Staneva, Marina, 981 Tardif, Manon, 1555 Tuttle, Joel V., 868 Waguespack, Christy, 2380 Stanislawski, Marc, 969 Tarpley, W. Gary, 1277 Tyms, A. Stanley, 1780 Wain, John, 1716 St. Clair, Marty H., 1590 Tauber, Martin G., 1186 Tzelepi, Eva, 2207 Wainberg, Mark A., 275, 986, Steckelberg, James M., 2191 Taylor, Debra L., 1780 Tzouvelekis, Leonidas S., 2207 1008 Steele, Paul, 2572 Taylor, Ethan Will, 268 Wakabayashi, Eiji, 594 Stein, Daniel S., 1541 Taylor, Jerry L., 853 Ubasawa, Masaru, 688 Wakebe, Hirokazu, 2340 VOL. 38, 1994 AUTHOR INDEX ix

Wakefield, John K., 2300 Wennersten, C. B., 534 Wong, Frankie A., 799 Yeni, Patrick, 177, 963 Wald, Anna, 174 Wennersten, Christine B., 144 Wong, Melinda, 499 Yokota, Takeshi, 138 Waldvogel, Francis A., 1703 Werner, K., 345 Wood, Craig A., 1023 Yoneda, Hiromitsu, 2340 Walker, James L., 2392 Wesche, David L., 1813 Wormser, Gary P., 1363, 2215 Yoshida, Hiroaki, 2014 Walker, Karla J., 2003 Wexler, Hannah M., 2504, 2513 Wright, Colin W., 96 Yoshida, Ryoji, 738, 790 Walker, Richard T., 688 Wheat, Joseph L., 576 Wright, Esther L., 2287 Yoshida, Takuji, 1466 Wallace, Richard J., Jr., 381 White, Michael, 2572 Wu, Helen, 905 Yoshimura, Fuminobu, 71 Wallace, R. J., Jr., 1408 White, Nicholas J., 1716 Wu, Martin, 1838 Young, Lowell S., 1200, 1838, Walmsley, S. L., 1678 White, N. J., 511 Wu, Pei-Jun, 494 1844, 2717 Walsh, Thomas J., 518, 713, Whittington, W. L., 1661 Wu, Tai, 729 Young, Robert D., 2871 1303, 2883 Wickramasinghe, Anura, 256 Wunderink, Richard G., 547 Yu, F. P., 2125 Walzer, Peter D., 2572 Williams, Diana L., 1651, 2380 Wyble, Lance E., 2024 Yuasa, Satoshi, 688 Wang, Laurene H., 1534 Williams, Jennifer Marin, 1123 Wyde, Philip R., 356 Wang, Shaomeng, 1794 Williams, Roger, 260 Zabinski, Richard A., 2003 403 Xerri, Luigi, 2362 Zakula, Dorothy, 1496 Wang, Yulin, 2648 Wilson, R. Geoffrey, R. A., 2750 Warhurst, David C., 96 Wilson, R. J. M., 511 Xia, Huaxiang, 2357 Zambias, Q., 883 Zameck, Ricki L., 547 Warren, Michael M., 2768 Wilson, Samuel Z., 356 Xiong, Yan Zarins, Lidija T., 2495 Wasan, Kishor M., 223, 2224 Wilson, Walter R., 2191 Zaror-Behrens, Gloria, 894 Washington, J. A., 1868 Winkler, I., 2710 Yabuuchi, Youichi, 2340 Zbinden, Irene, 2910 Washington, John A., 2194 Winslow, Dean, 307 Yahalom, Rina, 2612 Zebedee, Suzanne L., 1507 Wasserman, Bruce P., 1378 Winstanley, David J., 767 Yakubu, Davis E., 1256 Zella, Davide, 38 Watanabe, Noboru, 353 Winter, Carol, 174 Yamaguchi, Hideyo, 2204 Zenke, Gerhard, 1763 Watkins, William J., 403 Winter, Helen R., 781 Yamaguchi, Hitomi, 1374 Zervos, Marcus J., 1152 Watts, Paul, 2008 Winterscheid, Karen K., 1661 Yamaguchi, Keizo, 528, 1118 Zhai, Lin, 1470 Wauters, Georges, 1675 Wirth, Dyann F., 1419 Yamaguchi, Yoshiyuki, 969 Zhanel, George G., 1165 Wayne, Lawrence G., 2054 Wise, R., 1096, 2369 Yamamoto, Naohiko, 668 Zhang, Da, 282 Weber, Patricia A., 2280 Wisniewski, Ralph M., 1023 Yamashita, Toyoko S., 2817 Zhou, Xiang Yang, 1085 Weidekamm, E., 1219 Witvrouw, Myriam, 668 Yan, S. Betty, 937 Zhu, Yaqi, 388, 861 Weigel, Linda M., 330 Witwicki, E., 1678 Yang, Youjun, 2078, 2116 Ziebuhr, Wilma, 1251 Weinberg, Geoffrey A., 997 Woestenborghs, Robert, 2863 Yarlett, Nigel, 563 Ziffer, Hermann, 1854 Weinstein, John N., 1036 Wolanski, Bohdan S., 1404 Yasuda, Hiroshi, 138 Zimmerli, W., 1309 Weller, Stephen, 1534 Wolfe, A., 2827 Yazawa, Katsukiyo, 2197 Zinner, Stephen H., 2351 Weller, Ulrich, 13 Wolff, Barbara, 1763 Yeaman, Michael R., 729, 1460 Zipeto, Donato, 38 Weltzin, Richard, 2785 Wolfgang, Jill A., 1404 Yeamput, C., 511 Zuckier, Lionel S., 580 Wenger, Roland, 1763 Wondrack, Lillian, 2008 Yellin, Albert E., 151 Zurini, Mauro, 1763 SUBJECT INDEX VOLUME 38 aadA2 combination, 853 treatment of murine infections by incor- pSA Amikacin poration into egg lecithin-bile salt revised analysis, 1172 human necrotizing pancreatitis mixed micelles, 294 Acanthamoeba spp. behavior, 830 cryptococcosis polyaminopropyl biguanide P. aeruginosa treatment of murine infections by incor- quantitation and kinetics of killing, 886 pharmacokinetic and pharmacodynamic poration into egg lecithin-bile salt Acinetobacter baumannii approach for comparing two thera- mixed micelles, 294 aac(6')-Ih peutic regimens, 981 errata characterization of plasmid gene, 1883 Tn1528 influence of lipoproteins on renal cyto- susceptibility testing characterization for resistance studies, toxicity and antifungal activity, clinical isolates from Singapore, 2502 702 2230 Acinetobacter calcoaceticus Aminocyclitols itraconazole ciprofloxacin Mycobactenum spp. comparison for experimental pulmonary serum bactericidal activities in 30 pa- in vitro susceptibilities, 134 aspergillosis, 1303 tients, 837 Aminoglycoside 3'-phosphotransferases murine cryptococcosis Acinetobacter sp. 13 type IIa in vitro renal toxicity and in vivo thera- aac(6')-Ij purification and characterization and peutic efficacy associated with in- characterization of gene, 1883 kinetic comparison with new mu- tralipid, 177 Acinetobacter spp. tant enzyme, 641 murine trichosporonosis PCR Aminoglycosides efficacy compared with those of tria- detection of aac(6')-I gene in amikacin- gentamicin zoles and amphotericin B-triazoles, resistant strains, 2925 once-daily dosing assessed by MIC re- 2541 Acridine alkaloids version time, 1165 mycoses P. falciparum LLC-PK1 cells molecular and cellular aspects of incor- in vitro activities, 1169 induction of increase in intracellular poration in egg lecithin-bile salt Acute otitis media calcium, 1065 mixed micelles, 294 amoxicillin-clavulanate Mycobacterium spp. pharmacokinetics comparison of suspensions for treat- in vitro susceptibilities, 134 concentration in serum and distribution ment of children, 315 pharmacokinetics in tissue in rats during intralipid cefuroxime axetil comparison with Asian, Hispanic, and infusion, 2224 comparison of suspensions for treat- Caucasian patients by using popu- safety of unilamellar liposomal formula- ment of children, 315 lation pharmacokinetic methods, tion in rabbits, 713 Acyclovir 2073 renal cytotoxicity comparative evaluation effect of fever and changes in glomeru- influence of lipoproteins, 223 high versus standard dose for first-epi- lar filtration rate, 620 saperconazole sode genital herpes infections, 174 tobramycin efficacy and interactions in therapy of herpes simplex virus once-daily dosing assessed by MIC re- murine disseminated candidiasis, regulation of thymidine kinase in cells version time, 1165 371 treated with synergistic antiviral Amoxicillin synergy combination, 853 bioavailability alkyl glycerol ethers, 1523 Aeromonas salmonicida effects of presystemic degradation in T. glabrata quinolone resistant the intestine of rats, 842 treatment of disseminated infection, gyrA mutations in isolates of the fish L. monocytogenes 1604 pathogen, 2460 inhibition of intracellular growth, 438 toxic pathways Aeromonas spp. pharmacokinetics endocytic process in CHO cells, 2373 P-lactam resistance simulation in humans for prevention of Amphotericin B deoxycholate motile isolates from clinical and envi- streptococcal endocarditis in rats, toxicity ronmental sources, 353 2846 influence of diet, 963 AIDS patients Y pestis Amphotericin B-liposomes cytomegalovirus treatment of murine infection, 481 Candida spp. effectiveness of foscarnet induction Amoxicillin-clavulanate systemic infections in mice, 356 treatment on quantitation of DNA, acute otitis media Ampicillin 38 comparison of suspensions for treat- C. albicans GLQ223 ment of children, 315 colonization of gastrointestinal tracts of safety, activity, and pharmacokinetics, C. albicans mice, 602 260 colonization of gastrointestinal tracts of E. faecium resistance Ajoene mice, 602 correlation with overproduction of low- malaria Amoxicillin-clavulanic acid affinity penicillin-binding protein, in vivo activity against infections in ro- B. burgdorferi 1980 dents, 337 effectiveness of treatment in mice, 1567 Anaerobic bacteria Albendazole Amphotericin B DU-6859a P. carinii antifungal activity in vitro activity, 2504 inhibition of proliferation in inoculated influence of lipoproteins, 223 glycylcyclines immunosuppressed mice, 1834 C. albicans in vitro activities of N,N-dimethylglycyl- Alkyl glycerol ethers accumulation in human monocytes po- amido derivatives of minocycline synergy tentiates killing, 13 and 6-demethyl-6-deoxytetracycline amphotericin B, 1523 antagonistic effects of fluconazole and against 339 strains, 2513 Alpha interferon 5-fluorocytosine with human se- GV104326 herpes simplex virus rum, 1331 in vitro activities of the tribactam, 2362 regulation of thymidine kinase in cells physicochemical cell damage, 363 Anaerobic organisms treated with synergistic antiviral candidiasis biapenem

x VOL. 38, 1994 SUBJECT INDEX xi

in vitro activity, 889 transcriptase inhibitor, 288 Bacteria CP 99,219 Azithromycin anastomotic insufficiency comparison with ciprofloxacin, grepa- B. burgdorferi major pathogenic factor, 2564 floxacin, metronidazole, cefoxitin, effectiveness of treatment in mice, 1567 Bacteroides fragilis piperacillin, and piperacillin-ta- bacterial enteric pathogens BAY Y 3118 zobactam, 2471 intracellular activity, 1915 comparative activities, 1442 WY-49605 chlamydia P-lactams activity compared with those of amoxi- in vitro and in vivo activities, 2296 contribution of enzymatic properties, cillin, amoxicillin-clavulanate, imi- L. pneumophila cell permeability, and enzyme ex- penem, ciprofloxacin, cefaclor, cef- pharmacokinetics and intracellular con- pression to microbiological activi- podoxime, cefuroxime, clindamycin, centrations in infected and unin- ties in isolates that harbor a met- and metronidazole against 384 fected guinea pigs, 217 allo-,B-lactamase gene, 2116 anaerobes, 2599 M. avium clinafloxacin Anthelmintic benzimidazoles comparative activities against infection comparative activities, 1442 C. neoformans in beige mice, 1452 E-4868 in vitro susceptibility, 378 intermittent dosing for treatment of comparative activities, 1442 Antimycobacterial agents beige mice, 1721 E-5065 efficacy M. avium complex comparative activities, 1442 bone marrow-derived murine macro- inhibition of binding to HT-29 intestinal E-5068 phage model for evaluation, 2557 mucosal cells, 1200 comparative activities, 1442 Antiviral nucleoside analogs M. kansasii susceptibility testing human DNA polymerases activities in beige mice, 1455 longitudinal study with five agents in effects, 2743 M. malmoense three medical centers, 2276 mitochondrial DNA synthesis activities in beige mice, 1455 Bacteroides spp. effects, 2743 M simiae metronidazole Arcanobacterium haemolyticum activities in beige mice, 1455 in vitro activities of drug and its hy- susceptibility testing, 142 M xenopi droxy metabolite, 2106 Arthritis activities in beige mice, 1455 5-nitroimidazole doxycycline murine malaria nucleotide sequence analysis, 1047 reduction of matrix metalloproteinase efficacy as a causal prophylactic agent, Bacteroides uniformis 8-neutrophil collegenase levels dur- 1862 cbL4 ing long-term treatment, 400 N. gonorrhoeae molecular and genetic analysis of Aspergillosis susceptibility of isolates from women cephalosporinase gene encoding amphotericin B colloidal dispersion with pelvic inflammatory disease, species-specific ,B-lactamase, 1711 dose-dependent antifungal activity and 1688 BAY Y 3118 nephrotoxicity, 518 Oxyrase agar dilution human polymorphonuclear leukocytes minireview comparison with reference agar dilution intracellular penetration and activity, strategies in prevention for immunosup- method for susceptibility testing of 2426 pressed or neutropenic patients, anaerobes, 211 Bay y3118 911 P. aeruginosa gram-negative bacteria Aspergillus fumigatus in vitro exoenzyme-suppressing activi- activity against quinolone-resistant amphotericin B ties, 528 strains, 422 new in vitro assay based on glucose penetration activity against quinolone-susceptible consumption for determining activ- intracellular and extracellular penetra- strains, 422 ities, 2857 tion into inflammatory and nonin- gram-positive bacteria antifungal agent combinations flammatory blister fluid, 2449 activity against quinolone-resistant effects of those administered simulta- T gondii strains, 422 neously and seqentially, 2843 localization in infected cells, 1620 activity against quinolone-susceptible (1,3)-p-D-glucan synthase T. gondii resistance strains, 422 characterization and cilofungin inhibi- comparison of mutants, 31 Benomyl tion, 937 Azlocillin C. albicans cyclosporin A P. aeruginosa gene encoding resistance is multidrug in vitro and ex vivo effects on phago- time-survival studies for quantifying resistance gene, 648 cytic host defenses, 2883 effects, 1271 Benzimidazoles itraconazole Azoles 13-tubulin sequence new in vitro assay based on glucose C. albicans resistance correlation and antiprotozoal activities, consumption for determining activ- oropharyngeal strains isolated from pa- 2086 ities, 2857 tients with human immunodefi- Benzoxazinorifamycins lipopeptides ciency virus, 2495 KRM 1648 morphological effects correlate with Aztreonam activity against M. avium complex in activities against (1,3)-,B-D-glucan typhoid fever vitro and in macrophages, 1838 synthase, 1480 randomized comparison, 558 1-Lactamases 3'-Azido-3'-deoxythymidine B. uniformis antiretroviral activities Babesia divergens molecular and genetic analysis of cblA, differential activities and intracellular lovastatin cephalosporinase gene, 1711 metabolism in human cells, 1573 inhibition of in vitro development in blaBII,l feline immunodeficiency virus human erythrocytes, 1144 cloning and sequence analysis of gene multiple-drug-resistant mutants, 861 simvastatin in E. coli BS, 1182 human immunodeficiency virus type 1 inhibition of in vitro development in carbamates effect of establishment of infection in human erythrocytes, 1144 hydrolysis, 959 cultured CD8+ lymphocytes, 986 Bacillus licheniformis CAZ-3 inhibition of replication in vitro with amoebicin M4-A sequence, 2452 bisheteroarylpiperazine reverse biological activity from strain M-4, 1820 chromosomal xii SUBJECT INDEX ANTIMICROB. AGENTS CHEMOTHER.

antibodies against, 2306 S. pneumoniae susceptibilities of isolates from patients, clavulanate resistance in vitro selective concentrations, 122 848 reversal conferred by mutant of TEM-1, synergy Candida albicans 1134 glycopeptides and glycopeptide-resistant 22,23-epoxy-2-aza-2,3-dihydrosqualene clavulanic acid strains of E. faecium, 824 inhibition of sterol synthesis in conjunc- comparative activities, 767 X maltophilia tion with corresponding N-oxide, CTX-2 susceptibilities of 123 strains tested by 1904 sequence, 2452 five methods, 2317 amoxicillin-clavulanate extended spectrum Biapenem colonization of gastrointestinal tracts of clinical isolates of E. gergoviae and E. anaerobic organisms mice, 602 coli resistant to ceftazidime in in vitro activity, 889 amphotericin B China, 2838 Bioavailability accumulation in human monocytes po- K pneumoniae amoxicillin tentiates killing, 13 gene sequence and biochemical charac- effects of presystemic degradation in antagonistic effects of fluconazole and terization of FOX-1, 2150 the intestine of rats, 842 5-fluorocytosine with human se- identification of extended-spectrum isoniazid rum, 1331 TEM-12 and TEM-10 in single iso- effect of antacids in didanosine tablet, physicochemical cell damage, 363 late, 761 894 ampicillin TEM-26 responsible for major outbreak Biofilms colonization of gastrointestinal tracts of of ceftazidime-resistant infections, antibiotic killing efficacy mice, 602 392 mechanism of electrical enhancement, azole resistant M. fortuitum 2803 oropharyngeal strains isolated from pa- use of chromosomal class A to study P. aeruginosa tients with human immunodefi- substrates and inhibitory P-lactam biofilm accumulation model that pre- ciency virus, 2495 compounds, 1608 dicts antibiotic resistance, 1052 benomyl metallo Bleomycin gene encoding resistance is multidrug rapid identification, 991 S. cerevisiae resistance gene, 648 P. aeruginosa potentiation of cytotoxicity, 1615 chloramphenicol sequence analysis of PER-1 and com- Borrelia burgdorferi colonization of gastrointestinal tracts of parison with class A ,-lactamases, amoxicillin-clavulanic acid mice, 602 104 effectiveness of treatment in mice, 1567 ciprofloxacin cephalosporin 3'-quinolone esters azithromycin colonization of gastrointestinal tracts of hydrolysis, 959 effectiveness of treatment in mice, 1567 mice, 602 S. aureus ceftriaxone D0870 production of A and C variants by me- effectiveness of treatment in mice, 1567 in vitro activity of the new antifungal thicillin-resistant strains, 1649 chloramphenicol triazole against isolates from oral serine effectiveness of treatment in mice, 1567 cavities of patients infected with rapid identification, 991 doxycycline human immunodeficiency virus, Sme-1 effectiveness of treatment in mice, 1567 2553 cloning and sequence analysis of gene erythromycin fluconazole from S. marcescens, 1262 effectiveness of treatment in mice, 1567 improved medium for susceptibility sulbactam oxytetracycline testing, 45 comparative activities, 767 effectiveness of treatment in mice, 1567 fluconazole resistant tazobactam penicillin G in vitro activity of itraconazole against comparative activities, 767 effectiveness of treatment in mice, 1567 isolates from oral cavities of hu- TEM-1 Bronchopneumoniae man immunodeficiency virus pa- effect of threonine-to-methionine sub- ciprofloxacin tients, 1530 stitution at position 265 on struc- penetration into bronchial secretions itraconazole ture and function, 2266 from mechanically ventilated pa- in vitro activity against fluconazole-sus- TEM-26 tients with nosocomial infections, ceptible and -resistant isolates from major outbreak of ceftazidime-resistant 901 oral cavities of human immunode- K pneumoniae, 392 Brucellosis ficiency virus patients, 1530 tertiary amines doxycycline-rifampin ketoconazole hydrolysis, 959 possible implications of interaction for in vivo pharmacokinetics and pharma- X maltophilia treatment, 2798 codynamics in human stratum cor- biochemical properties, 2143 neum, 90 ,B-Lactams Campylobacter spp. meningitis Aeromonas sp. resistance macrolides effects of antifungal therapy on inflam- motile isolates from clinical and envi- evolution of susceptibilities, 1879 mation, sterilization, and histology, ronmental sources, 353 quinolones 83 E. coli evolution of susceptibilities, 1879 methotrexate effect of hyperproduction of TEM-1 susceptibility testing gene encoding resistance is multidrug P-lactamase, 494 10 antimicrobial agents against strains resistance gene, 648 oxyimino isolated from feces of pediatric miconazole interaction with class C 13-lactamase patients, 2917 in vivo pharmacokinetics and pharma- and mutant with spectrum ex- Cancer codynamics in human stratum cor- tended to ,-lactams, 1374 ciprofloxacin neum, 90 penicillin-binding proteins susceptibilities of isolates from patients, sulfamethoxazole-trimethoprim study and purification, 973 848 colonization of gastrointestinal tracts of S. aureus levofloxacin mice, 602 comparison with glycopeptides in treat- susceptibilities of isolates from patients, Candida krusei ment of subcutaneous abscesses, 848 liposomal amphotericin B (AmBisome) 1023 ofloxacin efficacy of escalating doses for infection VOL. 38, 1994 SUBJECT INDEX xiii

in neutropenic mice, 2660 with pelvic inflammatory disease, in vitro activity, 2896 Candida lusitaniae 1688 Cephalothin liposomal amphotericin B (AmBisome) Cefprozil multivariate analysis efficacy of escalating doses for infection otitis media comparative evaluation, 184 in neutropenic mice, 2660 penetration into middle ear fluid of pa- Chemiluminescence Candida spp. tients, 2210 penicillin-binding proteins alkyl glycerol ethers Ceftazidime study and purification, 973 synergism, 1523 cefepime Chlamydia amphotericin B comparative evaluation for bacterial azithromycin synergism, 1523 infections and sepsis syndrome, 415 in vitro and in vivo activities, 2296 amphotericin B-liposomes P. aeruginosa Chlamydia pneumoniae systemic infections in mice, 356 killing during infusion in an in vitro clarithromycin fluconazole pharmacokinetic model, 931 isolates from children with pneumonia, inhibition of adherence to platelets in Ceftibuten 1588 vitro, 1460 experimental intra-abdominal infections erythromycin susceptibilities and distribution of spe- optimal times above MIC, 1112 isolates from children with pneumonia, cies recovered from blood culture Ceftriaxone 1588 isolates over 5-year period, 1422 B. burgdorfeni minireviews platelet microbicidal protein effectiveness of treatment in mice, 1567 antimicrobial susceptibility and therapy inhibition of adherence to platelets in enteric fever of infections, 1873 vitro, 1460 comparison with ofloxacin for short- ofloxacin Candidiasis course treatment, 1716 in vitro activities, 1402 amphotericin B Legionella spp. OPC-17116 treatment of murine infections by incor- in vitro extracellular and intracellular in vitro activities, 1402 poration into egg lecithin-bile salt activities, 200 sparfloxacin mixed micelles, 294 meningitis in vitro activities, 1402 lanoconazole concentrations in cerebrospinal fluid of protective effects in experimental pneu- therapeutic efficacy for experimental children receiving dexamethasone monia in leukopenic mice, 1757 cutaneous infections in guinea pigs, therapy, 1209 Chlamydia trachomatis 2204 N. gonorrhoeae amoxicillin-clavulanic acid Capreomycin susceptibility of isolates from women murine model of infection, 1937 M. avium with pelvic inflammatory disease, azithromycin pharmacokinetics, toxicity, and efficacy 1688 murine model of infection, 1937 of liposomal form in disseminated pharmacokinetics dirithromycin mouse model, 2695 patients with typhoid fever, 2415 in vitro activity, 2213 Carbapenems plasma exchange in polyarteritis nodosa tetracyclines letter to the editor patients, 1519 murine model of infection, 1937 retain intermittent dosing, 159 S. pneumoniae Chloramphenicol S. pneumoniae efficacy against penicillin-susceptible B. burgdorferi susceptibilities of penicillin-susceptible and -resistant strains in a mouse effectiveness of treatment in mice, 1567 and -resistant isolates, 898 pneumonia model, 1953 C. albicans Cecropin B sparfloxacin colonization of gastrointestinal tracts of enterobacterial outer membrane comparative evaluation for treatment of mice, 602 ability to penetrate, 2498 experimental endocarditis due to E. coli Cefaclor penicillin-susceptible and -resistant active efflux in susceptible strains and experimental intra-abdominal infections streptococci, 2683 multiple-antibiotic-resistant mu- optimal times above MIC, 1112 Y pestis tants, 542 Cefazolin treatment of murine infection, 481 typhoid fever high-performance liquid chromatography Ceftriaxone-tazobactam randomized comparison, 558 penetration of and bactericidal activity Legionella spp. Chlorhexidine within endothelial cells, 1059 in vitro extracellular and intracellular biocidal action Staphylococcus spp. activities, 200 annulment by nicotinic acid, 2458 prophylactic efficacy in an experimental Cefuroxime Chlorofluoroquinolones wound infection, 1325 high-performance liquid chromatography BAY y 3118 Cefepime penetration of and bactericidal activity increased activity compared with those ceftazidime within endothelial cells, 1059 by other antimicrobial agents, 1671 comparative evaluation for bacterial Cefuroxime axetil Chloroquine infections and sepsis syndrome, 415 acute otitis media P. falciparum resistance Cefixime comparison of suspensions for treat- enhancement of susceptibility by neuro- urinary tract infections ment of children, 315 nal monoamine reuptake inhibi- studies with women comparing 3-day Cephalexin tors, 1419 regimens, 1176 fosfomycin trometamol Cilofungin Cefotaxime comparative regimens for treatment of fluorescent probe Y pestis uncomplicated lower urinary tract monitoring of antifungal drug-mem- treatment of murine infection, 481 infections in women, 2612 brane interactions, 1378 Cefotetan Cephalosporins Ciprofloxacin penetration FK-037 A. calcoaceticus suction skin blister fluid and tissue ho- pharmacokinetics and distribution in serum bactericidal activities in 30 pa- mogenates in patients undergoing tissue, 2369 tients, 837 abdominal surgery, 2221 S. pneumoniae antagonism Cefoxitin susceptibilities of penicillin-susceptible GABAA receptor of rat vagus nerve, N. gonorrhoeae and -resistant isolates, 898 1356 susceptibility of isolates from women SCE-2787 bioavailabilities xiv SUBJECT INDEX ANTIMICROB. AGENTS CHEMOTHER.

effect of enteral feeding with Ensure, with norfloxacin to prevent sponta- Coagulase-negative staphylococci 2101 neous bacterial peritonitis, 340 minireviews bioavailability Clarithromycin antimicrobial susceptibility, 2231 effect of bismuth subsalicylate, 2187 C. pneumoniae susceptibility testing bronchopneumonia isolates from children with pneumonia, minireview, 2231 penetration into bronchial secretions 1588 Coagulase-negative streptococci from mechanically ventilated pa- H. influenzae platelet microbicidal protein tients with nosocomial infections, evaluation of activities by using an in in vitro resistance correlates with endo- 901 vitro pharmacodynamic model, carditis source, 729 C. albicans 2003 Colonization resistance colonization of gastrointestinal tracts of H. pyloni letter to the editor, 1693 mice, 602 tight binding to ribosomes, 1496 minireview, 409 cancer lepromatous leprosy Combinatorial libraries susceptibilities of isolates from patients, clinical trial, 515 water-soluble synthetic peptides 848 M. avium identification of antimicrobial peptides, E. cloacae comparative activities against infection 2280 serum bactericidal activities in 30 pa- in beige mice, 1452 Coryneforms tients, 837 treatment and prevention of dissemi- quinolones E. coli nated infection in beige mice, comparative activities of eight new serum bactericidal activities in 30 pa- alone and in combination with agents, 1439 tients, 837 dapsone, 2717 Co-trimoxazole E. coli resistance M. avium-M. intracellulare complex L. monocytogenes association between double mutation in liposome encapsulated, efficacies of, 523 inhibition of intracellular growth, 438 gyrA gene of clinical isolates and M. intracellulare resistance CP 99,219 MICs, 2477 identifications of mutations in 23S cefoxitin high-performance liquid chromatography rRNA gene, 381 comparative activities against 489 penetration of and bactericidal activity anaerobes, 2471 within endothelial cells, 1059 M. kansasii ciprofloxacin imipenem-cilastatin activities in beige mice, 1455 comparative activities against 489 comparative evaluation for treatment of M. malmoense anaerobes, 2471 severe pneumonia in hospitalized activities in beige mice, 1455 grepafloxacin patients, 547 M. simiae comparative activities against 489 letters to the editor activities in beige mice, 1455 anaerobes, 2471 treatment of severe pneumonia, 1871 activity in murine model of dissemi- metronidazole multivariate analysis nated infection, alone and with comparative activities against 489 comparative evaluation, 184 ethambutol, 2676 anaerobes, 2471 P. aeruginosa M. xenopi piperacillin effects on in vitro adhesion and survival activities in beige mice, 1455 comparative activities against 489 of strain AK1 on urinary catheters, Oxyrase agar dilution anaerobes, 2471 1490 comparison with reference agar dilution piperacillin-tazobactam investigation of penetration into bio- method for susceptibility testing of comparative activities against 489 films, 2125 anaerobes, 211 anaerobes, 2471 serum bactericidal activities in 30 pa- penetration Cryptococcosis tients, 837 lung tissues from patients undergoing amphotericin B penetration lung resection, 876 treatment of murine infections by incor- human brain tissue, 1356 S. epidermidis poration into egg lecithin-bile salt pharmacokinetics interaction between antibiotic and bio- mixed micelles, 294 strains of S. pneumoniae, S. aureus, and films, 138 interleukin-12 P. aeruginosa for which MICs are Clavulanic acid efficacy alone and synergy with conven- similar, 2730 P-lactamases tional antifungal therapy, 460 pneumococci comparative activities, 767 Cryptococcus neoforinans antipneumococcal activities by time-kill Legionella spp. amphotericin B susceptibility methodology, 2065 in vitro extracellular and intracellular decrease of growth in presence of L- rabbits activities, 200 dopa, 2648 intestinal elimination, 757 Clinafloxacin anthelmintic benzimidazoles S. aureus E. faecium in vitro susceptibility, 378 serum bactericidal activities in 30 pa- fluconazole tients, 837 activity against multidrug-resistant sterol composition in presence and ab- S. marcescens strains, 1668 sence of drug, 2029 in vivo activities in an experimental X maltophilia immunoglobulin Gl monoclonal antibody model of endocarditis, 883 susceptibilities of 123 strains, 369 2H1 Staphylococcus spp. Clindamycin therapeutic efficacy alone and in combi- prophylactic efficacy in an experimental N. gonorrhoeae nation with amphotericin B, 580 wound infection, 1325 susceptibility of isolates from women macrophage colony-stimulating factor temafloxacin with pelvic inflammatory disease, effect of in vivo factor on fungistasis of effects on T-lymphocyte function, 879 1688 bronchoalveolar and peritoneal X maltophilia T. gondii resistance macrophages, 2162 susceptibilities of 123 strains, 369 comparison of mutants, 31 mouse-human immunoglobulin Gl chi- susceptibilities of 123 strains tested by Clostridium perfringens meric antibodies five methods, 2317 macrolide-lincosamide-streptogramin B activities, 1507 Cirrhosis resistance Cryptococcus spp. quinolone resistance cloning and sequence analysis of ermQ, alkyl glycerol ethers rapid emergence in patients treated 1041 synergism, 1523 VOL. 38, 1994 SUBJECT INDEX xv

amphotericin B alone or with tobramycin in renal proxi- effect of establishment of infection in synergism, 1523 mal tubular cells, 189 cultured CD8+ lymphocytes, 986 Cryptosporidium parvum Dehydroepiandrosterone 2',3'-Dideoxynucleosides paromomycin Cryptosporidium spp. human pluripotent progenitors evaluation of curative anticryptospo- studies with immunodeficient mouse effects on proliferation and differentia- ridial activity in a dexamethasone- model, 865 tion in liquid culture, 924 treated rat model, 1681 Dexamethasone Dientamoeba fragilis Cryptosporidium spp. M. avium complex susceptibility testing dehydroepiandrosterone low doses as adjunctive therapy for dis- iodoquinol, 1157 studies with immunodeficient mouse seminated infections in AIDS pa- metronidazole, 1157 model, 865 tients, 2215 paromomycin, 1157 lasalocid meningitis tetracycline, 1157 studies with immunodeficient mouse effect on therapy of experimental peni- Diethyldithiocarbamate model, 865 cillin- and cephalosporin-resistant human immunodeficiency virus sinefungin strains, 1320 decreased counts of blood neutrophils, studies with immunodeficient mouse Dextranase monocytes, and platelets in in- model, 865 viridans streptococci fected children and young adults, D-Cycloserine enhancement of antibiotic efficacy in 1644 transport mechanisms experimental endocarditis, 953 Dihydroacridinediones use in human intestinal cell line Caco 2, 2',3'-Dideoxy-2',3'-didehydrothymidine WR 243251 1239 human immunodeficiency virus antimalarial activity, 1753 Cyclothialidine comparison of mitochondrial morphol- Dipyridamole DNA gyrases ogy, mitochondrial DNA content, human immunodeficiency virus mechanism of inhibition, 1966 and cell viability in cultured cells, effect on zidovudine pharmacokinetics Cytomegalovirus 1824 and short-term tolerance in asymp- (S)-1-(3-hydroxy-2-phosphonylme- 2',3'-Dideoxy-3'-thiacytidine tomatic patients, 1036 thoxypropyl) cytosine human immunodeficiency virus resistance Dirithromycin activity as single-bolus dose and contin- identification of a mutation in the C. trachomatis uous fusion in in vitro cell culture IKKK motif of reverse tran- in vitro activity, 2213 perfusion system, 2404 scriptase, 275 neutrophils AIDS patients 2',3'-Dideoxycytidine effect on degranulation, 1548 effectiveness of induction treatment on human immunodeficiency virus DNA gyrases quantitation of DNA, 38 comparison of mitochondrial morphol- cyclothialidine foscamet ogy, mitochondrial DNA content, mechanism of inhibition, 1966 effectiveness of induction treatment on and cell viability in cultured cells, D0870 quantitation of DNA, 38 1824 T. glabrata pharmacokinetic parameters of mainte- human immunodeficiency virus resistance treatment of disseminated infection, nance doses and clinical outcome identification of a mutation in the 1604 of retinitis, 1190 IKKK motif of reverse tran- Cytotoxicity scriptase, 275 Doxycycline bisbenzylisoquinolone alkaloids human immunodeficiency virus type 1 arthritis KB cell line, 96 inhibition of replication in vitro with reduction of matrix metalloproteinase bisheteroarylpiperazine reverse 8-neutrophil collegenase levels dur- Dapsone transcriptase inhibitor, 288 ing long-term treatment, 400 absorption resistance of reverse transcriptase con- B. burgdorferi evaluation of effects of altered gastric ferred by mutation in codon 65, effectiveness of treatment in mice, 1567 pH with healthy volunteers, 2227 282 N. gonorrhoeae M. avium Dideoxycytidine nucleosides susceptibility of isolates from women treatment and prevention of dissemi- hepatitis B virus with pelvic inflammatory disease, nated infection in beige mice, influence of stereochemistry on antiviral 1688 alone and in combination with cla- activities and resistance profiles, Y pestis rithromycin, 2717 868 treatment of murine infection, 481 P. carinii human immunodeficiency virus type 1 Duck hepatitis B virus levels in serum during once-weekly dos- influence of stereochemistry on antiviral penciclovir ing, 1197 activities and resistance profiles, in vitro activity, 719 pharmacokinetics 868 safety of weekly doses for prevention of Dideoxyinosine Encephalitozoon cuniculi pneumocystis pneumonia, 1580 pharmacokinetics microculture method Dapsone plus pyrimethamine neonatal pigtailed macaques, 787 in vitro model to assess effect of antimi- pharmacokinetics transplacental studies with pigtailed ma- crobial agents, 2440 safety of weekly doses for prevention of caques, 781 Endocarditis pneumocystis pneumonia, 1580 2',3'-Dideoxyinosine RP 59500 Daptomycin antiretroviral activities in vivo activities and penetration of two multivariate analysis differential activities and intracellular components, 432 comparative evaluation, 184 metabolism in human cells, 1573 S. aureus nephrotoxicity feline immunodeficiency virus activities of teicoplanin, vancomycin, gentamicin induced; attenuation of, multiple-drug-resistant mutants, 861 and gentamicin alone and in com- 1027 human immunodeficiency virus bination in an in vitro pharmacody- S. aureus comparison of mitochondrial morphol- namic model, 2034 role of tolerance in treatment and pro- ogy, mitochondrial DNA content, Endotoxins phylaxis of experimental endocardi- and cell viability in cultured cells, minireview tis, 487 1824 clinical relevance of antibiotic-induced subcellular distribution human immunodeficiency virus type 1 release, 1211 xvi SUBJECT INDEX ANTIMICROB. AGENTS CHEMOTHER.

Entamoeba histolytica multidrug resistant methodology, 2065 bisbenzylisoquinolone alkaloids activity of clinafloxacin, 1668 Erythromycylamine in vitro activities, 96 bactericidal activities of peptide antibi- neutrophils Enterobacter cloacae otics, 385 effect on degranulation, 1548 ciprofloxacin vancomycin resistant Escherichia coli serum bactericidal activities in 30 pa- bactericidal activities of antibiotics Aeromonas sobria AER 14M tients, 837 alone and in combination, 1225 cloning and expression of a cloxacillin- Enterobacter gergoviae outbreak of bacteremia in an adult on- hydrolyzing enzyme and a cepha- 1-lactamases cology unit, 1363 losporinase, 2078 clinical isolates resistant to ceftazidime Enterococcus flavescens ,B-lactamase inhibitor resistance in China, 2838 D-alanine-D-alanine ligases emergence of clinical isolates producing Enterobactenaceae analysis of genes encoding enzymes, TEM-1 derivatives or an OXA-1 meropenem 1788 3-lactamase, 1085 postantibiotic effect determined by five Enterococcus gallinarum 3-lactamases methods, 2583 glycopeptide resistant clinical isolates resistant to ceftazidime Enterococcus casseliflavus emergence of strains with high-level in China, 2838 D-alanine-D-alanine ligases resistance, 1675 ,-lactams analysis of genes encoding enzymes, Enterococcus spp. effect of hyperproduction of TEM-1 1788 fluoroquinolones 3-lactamase, 494 glycopeptide resistant dissociated resistance among strains, susceptibility in vitro, 494 emergence of strains with high-level 2095 bioluminescent resistance, 1675 gentamicin resistant nitric oxide-mediated killing, 2775 Enterococcus faecalis transferability and genetic relatedness, chloramphenicol CX19 1194 active efflux in susceptible strains and insertions of IS256-like element flank- Epiroprim multiple-antibiotic-resistant mu- ing chromosomal 1-lactamase T. gondii tants, 542 gene, 693 activity alone and in combination with ciprofloxacin DU-6859a dapsone, 1803 in vitro activities against strains isolated comparative in vitro activity against Epstein-Barr virus from diarrheic lambs and kids, gram-positive cocci, 611 mycophenolic acid 2469 gentamicin resistant effect on infection of human B lympho- serum bactericidal activities in 30 pa- encoding of high-level resistance by cytes, 126 tients, 837 Tn924, 1152 thymidine kinase ciprofloxacin resistant glycopeptide resistance substrate specificity, 2175 association between double mutation in contribution of VanY D,D-carboxypepti- Errata gyrA gene of clinical isolates and dase by hydrolysis of peptidoglycan A. fumigatus MICs, 2477 precursors, 1899 morphological effects of lipopeptides enoxacin PCR and correlation with activities in vitro activities against strains isolated analysis and direct DNA sequencing of against (1,3)-p-D-glucan synthase, from diarrheic lambs and kids, gyrA mutations associated with 2516 2469 fluoroquinolone resistance, 2091 acute otitis media enrofloxacin platelet microbicidal protein comparison of cefuroxime axetil and in vitro activities against strains isolated in vitro resistance correlates with endo- amoxicillin-clavulanate suspensions, from diarrheic lambs and kids, carditis source, 729 2516 2469 tetracycline resistance amphotericin B feline immunodeficiency virus presence of Listeria gene tet(S), 2330 influence of lipoproteins on renal cyto- expression of viral reverse transcriptase, vancomycin susceptibility toxicity and antifungal activity, 388 Tn9O7 insertion mutants, 473 2230 fluoroquinolone resistant Enterococcus faecium CP-99,219 characterization of mutants selected in aminoglycoside resistant in vitro activity, 909 vitro, 1284 outbreak of bacteremia in an adult on- Y pestis emergence at a cancer center, 681 cology unit, 1363 assessment of a fluoroquinolone, ,-lac- leukotriene inhibitors ampicillin resistant tams, aminoglycosides, and a cy- L-651,392 controls inflammatory pro- correlation with overproduction of low- cline, 1694 cess in pyelonephritis, 1555 affinity penicillin-binding protein, Erythromycin multiple antibiotic resistance 1980 B. burgdorferi genetic relationship between soxRS and outbreak of bacteremia in an adult on- effectiveness of treatment in mice, 1567 mar loci in promotion, 1773 cology unit, 1363 C. pneumoniae penicillin-binding proteins bacteremia isolates from children with pneumonia, regulation by rpoS during transitions in outbreak of vancomycin-, ampicillin-, 1588 growth states, 205 and aminoglycoside-resistant H. pylori quinolones strains in an adult oncology unit, tight binding to ribosomes, 1496 comparison of inhibition of topoisomer- 1363 lipopolysaccharide-induced airway inflam- ase IV with DNA gyrase inhibition, P-lactams mation 2623 synergy and resistance to synergy, 824 inhibition of vascular leakage and neu- sparfloxacin clinafloxacin trophil accumulation in rat trachea, in vitro activities against strains isolated activity against multidrug-resistant 1641 from diarrheic lambs and kids, strains, 1668 Oxyrase agar dilution 2469 DU-6859a comparison with reference agar dilution susceptibility testing comparative in vitro activity against method for susceptibility testing of isoniazid and peroxides, 1829 gram-positive cocci, 611 anaerobes, 211 glycopeptides pneumococci Famciclovir synergy and resistance to synergy, 824 antipneumococcal activities by time-kill genital herpes VOL. 38, 1994 SUBJECT INDEX xvii

safety in patients, 2454 in resistance, 1991 treatment of murine infection, 481 herpes zoster M. tuberculosis resistance GLQ223 safety in patients, 2454 cloning and nucleotide sequences of patients with AIDS FCE 22891 gyrA and gyrB genes, 773 safety, activity, and pharmacokinetics, H. influenzae magnesium 260 efficacy and tolerability in patients with effect of antibacterial properties, 2810 Glycopeptides chronic obstructive pulmonary dis- P. falciparum E. casseliflavus ease, 872 in vitro activities, 1169 emergence of strains with high-level FDA approvals resistance resistance, 1675 anti-infective agents, biologics, and vac- dissociated resistance among staphylo- E. gallinarum cines approved in 1993, 908 cocci and enterococci, 2095 emergence of strains with high-level Feline immunodeficiency virus S. aureus resistance resistance, 1675 3'-azido-3'-deoxythymidine in vivo selection of a mutant during Glycylcyclines multiple-drug-resistant mutants, 861 pefloxacin therapy, 1149 6-demethyl-6-desoxytetracycline 2',3'-dideoxyinosine (6S)-6-Fluoroshikimic acid effectiveness against tetracycline-resis- multiple-drug-resistant mutants, 861 E. coli tant gram-positive cocci, 2218 E. coli action on aromatic biosynthetic path- anaerobic bacteria expression of viral reverse transcriptase, way, 403 in vitro activities of N,N-dimethylglycyl- 388 Foscarnet amido derivatives of minocycline Fialuridine AIDS patients and 6-demethyl-6-deoxytetracycline mitochondrial DNA effectiveness of induction treatment on against 339 strains, 2513 effect on replication in CEM cells and quantitation of DNA, 38 CL 329,998 in human hepatoblastoma cells in cytomegalovirus in vitro activities, 1096 culture, 1997 effectiveness of induction treatment on in vitro activities against gram-positive radioimmunoassays quantitation of DNA, 38 bacteria, 534 initial assessment of pharmacokinetics pharmacokinetic parameters of mainte- CL 331,002 after single oral doses to healthy nance doses and clinical outcome in vitro activities, 1096 volunteers, 2134 of retinitis, 1190 in vitro activities against gram-positive Fleroxacin human immunodeficiency virus bacteria, 534 activity suppression of replication, 604 M. hominis experimental intra-abdominal abscesses, Fosfomycin trometamol susceptibility compared with that to 252 cephalexin older tetracyclines, 2628 clindamycin comparative regimens for treatment of M. pneumoniae activity in intra-abdominal abscesses, uncomplicated lower urinary tract susceptibility compared with that to 252 infections in women, 2612 older tetracyclines, 2628 metronidazole Fusidic acid N,N-dimethylglycyl-amido derivative of activity in intra-abdominal abscesses, leprosy minocycline 252 clinical trial, 1651 effectiveness against tetracycline-resis- pharmacokinetics tant gram-positive cocci, 2218 effects of a fat- and calcium-rich break- Ganciclovir U. urealyticum fast, 499 redox targeting susceptibility compared with that to single doses to bacteremic patients, enhanced delivery to the brain, 817 older tetracyclines, 2628 1219 Genaconazole Gram-negative organisms Fluconazole pharmacokinetics antibiotic action C. albicans healthy men after oral and intravenous ultrasonic enhancement, 2577 improved medium for susceptibility administration, 2758 GV104326 testing, 45 Genital herpes in vitro activities of the tribactam, 2362 C. neoformans famciclovir minireviews sterol composition in presence and ab- safety in patients, 2454 transfer of antibiotic resistance genes, sence of drug, 2029 Gentamicin 1447 Candida spp. E. faecalis resistance Gram-positive organisms inhibition of adherence to platelets in encoding of high-level resistance by GV104326 vitro, 1460 Tn924, 1152 in vitro activities of the tribactam, 2362 susceptibilities, 1422 E. faecium minireviews pharmacokinetics activities alone and in combinations, transfer of antibiotic resistance genes, validation of animal model used to 1225 1447 measure drug concentrations in Enterococcus sp. resistance Group B streptococci cerebrospinal fluid, 2111 transferability and genetic relatedness, susceptibility testing Fluoroquinolones 1194 antibiotic resistance and penicillin toler- A-80556 human necrotizing pancreatitis ance in clinical isolates, 2183 in vitro and in vivo evaluations, 1071 behavior, 830 Guanylhydrazones alkyl substituents mouse model P. carinii pneumonia placement on C-7 piperazine ring, 130 treatment in a new experimental model therapy of immunosuppressed rats, chondrotoxicity of foreign body infection, 2047 2572 cytofluorometric analysis, 243 multivariate analysis CP-99,219 comparative evaluation, 184 Haemophilus ducreyi in vitro activity, 2615 N. gonorrhoeae trimethoprim-sulfamethoxazole resistant E. coli susceptibility of isolates from women emergence in Rwanda, 1647 characterization of mutants selected in with pelvic inflammatory disease, Haemophilus infiuenzae vitro, 1284 1688 14-hydroxyclarithromycin emergence at a cancer center, 681 pig kidney cell membrane evaluation of activities by using an in M. smegmatis fluidity during exposure, 2169 vitro pharmacodynamic model, characterization of mutations involved Y pestis 2003 xviii SUBJECT INDEX ANTIMICROB. AGENTS CHEMOTHER.

,-lactamase producing alpha interferon effect on zidovudine pharmacokinetics experimental respiratory infections in regulation of thymidine kinase in cells and short-term tolerance in asymp- neutropenic rats, 608 treated with synergistic antiviral tomatic patients, 1036 broth microdilution combination, 853 foscarnet in vitro activities of 12 orally adminis- foscarnet suppression of replication, 604 tered antimicrobial agents against correlation between response and sus- JM3100 respiratory pathogens from U.S. ceptibility result for isolates from potent and selective inhibition, 668 medical centers in 1992 and 1993, human immunodeficiency virus- levofloxacin 2419 infected patients, 1246 pharmacokinetics and safety in patients, clarithromycin imiquimod 799 evaluation of activities by using an in posttherapy suppression of genital her- pharmacokinetics vitro pharmacodynamic model, pes simplex virus recurrences and zidovudine phosphorylation in periph- 2003 enhancement of T-cell memory in eral blood mononuclear cells of FCE 22891 guinea pigs, 2059 patients, 1541 efficacy and tolerability in patients with Herpes simplex virus type 1 phosphatidylazidothymidine chronic obstructive pulmonary dis- immediate-early mRNAs uptake in mouse lymphoid tissues and ease, 872 synergistic antiviral activities of oligo- antiviral activities, 2792 susceptibility testing nucleoside methylphosphonates, phosphatidyl-ddC susceptibilities of Canadian isolates and 675 uptake in mouse lymphoid tissues and characterization of their ,-lactama- Herpes simplex virus type 2 antiviral activities, 2792 ses, 1678 HPMPC protease Helicobacterpylori comparative evaluation with cHPMPC, nonpeptide cyclic urea, DMP 323, 14-(R)-hydroxy metabolite 2387 blocks intracellular processing of tight binding to ribosomes, 1496 Herpes zoster gag polyprotein, 1635 clarithromycin famciclovir potency and selectivity of inhibition by tight binding to ribosomes, 1496 safety in patients, 2454 small nonpeptide cyclic urea, DMP erythromycin Herpesvirus 323, 1628 tight binding to ribosomes, 1496 2-amino-7-[(1,3-dihydroxy-2-propoxy) protease inhibitor KNI-272 metronidazole methyl]purine protein binding and alteration of anti- standardization of disk diffusion test potent and selective inhibition of repli- retroviral activity, 1107 and clinical significance for suscep- cation, 2710 reverse transcription tibility testing, 2357 High-pressure liquid chromatography preferential incorporation of nucleoside metronidazole resistance pefloxacin analogs after template switching, in vitro studies on stability and develop- determination of concentration in mes- 1008 ment, 360 enteric lymph nodes, 632 T cells Hepatitis B virus Himastatin inhibition of a-glucosidase I of glycop- alpha interferon fatty acid sodium salts rotein-processing enzymes of 6-0- inhibition in tissue culture, 2921 inhibition of antibacterial activity of the butanoyl castanospermine (MDL ,B-2',3'-dideoxycytidine analogs antitumor antibiotic, 2633 28,574) and its consequences, 1780 pure nucleoside enantiomers as selec- Human cytomegalovirus Tat antagonist tive inhibitors in vitro, 2172 alkenyl guanine analogs combinative interactions with reverse (-) cis-5-fluoro-1-[2-(hydroxymethyl)-1,3- inhibition in culture, 2889 transcriptase inhibitors and a pro- oxathiolan-5-yl]cytosine Human hepatitis B virus tease inhibitor, 348 evaluation with mice, 616 (2'R,5'S)-cis-5-fluoro-1-[2-(hydroxy- valaciclovir dideoxycytidine nucleosides methyl)-1,3-oxathiolan-5-yl] cytosine phase I trial in patients with advanced influence of stereochemistry on antiviral pharmacokinetics, oral bioavailability, disease, 1534 activities and resistance profiles, and metabolism in mice and cyno- Human immunodeficiency virus type 1 868 molgus monkeys, 2722 acyclic 6-phenylselenenyl- and 6-phenyl- duck Human immunodeficiency virus thiopyrimidines inhibitory effects of acyclic nucleoside azoles in vitro resistance, 2409 phosphonates on infections in tis- resistant C. albicans strains isolated 3'-azido-3'-deoxythymidine sue culture, 2180 from patients, 2495 effect of establishment of infection in (+) cis-5-fluoro-1-[2-(hydroxymethyl)-1,3- C. albicans cultured CD8+ lymphocytes, 986 oxathiolan-5-yl]cytosine azole-resistant strains isolated from pa- inhibition of replication in vitro with intercellular metabolism, 1230 tients, 2495 bisheteroarylpiperazine reverse (-) cis-5-fluoro-1-[2-(hydroxymethyl)-1,3- in vitro activity of itraconazole against transcriptase inhibitor, 288 oxathiolan-5-yl]cytosine fluconazole-susceptible and -resis- combination chemotherapy intercellular metabolism, 1230 tant isolates from oral cavities, alternating versus continuous drug regi- human 1530 mens, 656 inhibitory effects of acyclic nucleoside 5-chloro-2',3'-dideoxy-3'-fluorouridine 2',3'-didehydro-2',3'-dideoxythymidine phosphonates on infections in tis- improved metabolic and toxicological novel mutation in reverse transcriptase sue culture, 2180 profile, 1590 confers resistance in cell culture, oxetanocin G (2'R,5'S)-cis-5-fluoro-1-[2-(hydroxy- 1428 effect on DNA synthesis by virions, 707 methyl)-1,3-oxathiolan-5-yl] cytosine 2',3'-didehydro-3'-deoxythymidine Herpes simplex virus pharmacokinetics, oral bioavailability, effect in hollow-fiber pharmacodynamic acyclovir and metabolism in mice and cyno- model system, 1386 correlation between response and sus- molgus monkeys, 2722 2',3'-dideoxycytidine ceptibility result for isolates from diethyldithiocarbamate inhibition of replication in vitro with human immunodeficiency virus- decreased counts of blood neutrophils, bisheteroarylpiperazine reverse infected patients, 1246 monocytes, and platelets in in- transcriptase inhibitor, 288 regulation of thymidine kinase in cells fected children and young adults, dideoxycytidine nucleosides treated with synergistic antiviral 1644 influence of stereochemistry on antiviral combination, 853 dipyridamole activities and resistance profiles, VOL. 38, 1994 SUBJECT INDEX xix

868 Imidazole 894 2',3'-dideoxyinosine P. carinii Itraconazole effect of establishment of infection in resistance, 1859 amphotericin B cultured CD8+ lymphocytes, 986 Imipenem comparison for experimental pulmonary L enantiomer of 2',3'-dideoxycytidine E. faecium aspergillosis, 1303 in vitro activities and those of its activities alone and in combinations, C. albicans 5-fluoro derivative, 1292 1225 in vitro activity against fluconazole-sus- MKC-442 letters to the editor ceptible and -resistant isolates from preclinical evaluation, 688 treatment of severe pneumonia, 1871 human immunodeficiency virus pa- myeloperoxidase multivariate analysis tients, 1530 virucidal effect on T cells, 969 comparative evaluation, 184 cyclosporin A protease inhibitors P. aeruginosa interaction, 1303 effects on particle maturation and con- pharmacodynamic effects of subinhibi- pharmacokinetics stitutive production of nonenvel- tory concentrations in an in vitro bioassay using hydroxyitraconazole stan- oped particles by a mammalian cell dynamic model, 1416 dards, 1561 line, 2430 peritonitis correlation between therapeutic re- pyridoxal 5'-phosphate comparison of monotherapy with ther- sponse and concentrations in inhibition of in vitro infection and apy with imipenem plus netilmicin plasma, 1303 gpl20-CD4 interaction, 2483 for severe infections in nonneutro- receptor antagonists penic patients, 1309 JM3100 assays for detection and characteriza- pneumonia human immunodeficiency virus tion, 2008 comparison of monotherapy with ther- potent and selective inhibition, 668 recombinant virus assay apy with imipenem plus netilmicin for severe infections in nonneutro- Ketoconazole assessment of drug susceptibility iso- patients, 1309 lates, 23 penic C. albicans sepsis in vivo pharmacokinetics and pharma- reverse transcriptase comparison of monotherapy with ther- antiviral drug resistance mutations, 268 codynamics in human stratum cor- apy with imipenem plus netilmicin neum, 90 resistance to 2',3'-dideoxycytidine con- for severe infections in nonneutro- ferred by mutation in codon 65, L. mexicana penic patients, 1309 effect on lethal action of amphotericin 282 Imipenem-cilastatin inhibition by 5'-triphosphate c enanti- B on promastigotes, 1079 ciprofloxacin sucralfate omers of cytidine analogs, 2300 comparative evaluation for treatment of of mutations that in vitro analysis of interaction, 319 subunit specificity severe pneumonia in hospitalized in volunteers, confer resistance to nonnucleoside patients, 547 in vivo interaction healthy inhibitors in drug resistance, 1909 human necrotizing pancreatitis 326 reverse transcriptase inhibitors behavior, 830 Kiebsiella pneumoniae susceptibilities of enzyme and viral vari- Imiquimod f3-lactam-1-lactamase inhibitor combina- ants expressing multiple resistance- herpes simplex virus tion engendering amino acid substitu- posttherapy suppression of genital her- in vivo efficacies against TEM-26-pro- tions, 1404 pes simplex virus recurrences and ducing strain, 2663 SDZ NIM 811 enhancement of T-cell memory in 1-lactamases inhibition of replication, 1763 guinea pigs, 2059 gene sequence and biochemical charac- Influenza A virus terization of FOX-1, 2150 surface glycoprotein identification of extended-spectrum influence of host cell type and V3 loop 2'-deoxy-2'-fluororibosides efficacy in ferrets, 1864 TEM-12 and TEM-10 in single iso- on susceptibility to polyanion com- late, 761 pounds, 2910 LY217896 prevention of infection and illness in baAT1 tetrahydroimidazo[4,5,1-jk][1,4]-benzodiaz- nucleotide sequence of plasmid-medi- epen-2(1H)-one and -thione deriva- humans, 1178 sulfonic acid polymers ated cephalosporinase gene, 2207 tives ceftazidime resistant inhibition of replication, 2863 in vitro and in vivo inhibition, 256 Influenza B virus TEM-26 responsible for major out- U-75875 break, 392 activities in human brain cell cultures, 2'-deoxy-2'-fluororibosides efficacy in ferrets, 1864 muramyl tripeptide phosphatidylethanol- 2465 Influenza virus amide U-90152 cap-dependent endonuclease treatment of septicemia in normal and activities in human brain cell cultures, inhibition by 2,4-dioxobutanoic acid leukopenic mice, 147 2465 compounds, 2827 piperacillin-tazobactam viral genomic RNA GG167 different ratios for treatment of experi- reverse transcription capabilities, 2929 inhibition in mice consistent with extra- mental meningitis, 195 zidovudine resistant cellular activity of viral neuramini- TEM-26 susceptibilities of variants to inhibition dase, 2270 responsibility for major outbreak of by acyclic nucleoside phosphonates, Interleukin-12 ceftazidime-resistant infections, 392 1683 cryptococcosis tumor necrosis factor 14-Hydroxyclarithromycin efficacy alone and synergy with conven- influence of antimicrobial therapy on H. influenzae tional antifungal therapy, 460 kinetics in experimental endocardi- evaluation of activities by using an in Iontophoresis tis, 1017 vitro pharmacodynamic model, antimicrobial chlorine-based substances 2003 quantification, qualification, and micro- Lanoconazole bial killing efficiencies, 2768 candidiasis ICI D1694 Isoniazid therapeutic efficacy for experimental P. falciparum bioavailability cutaneous infections in guinea pigs, susceptibility, 476 effect of antacids in didanosine tablet, 2204 xx SUBJECT INDEX ANTIMICROB. AGENTS CHEMOTHER.

Lasalocid Levofloxacin 2643 Cryptosporidium spp. cancer M. pneumoniae studies with immunodeficient mouse susceptibilities of isolates from patients, in vitro and in vivo activities, 790 model, 865 848 midecamycin acetate Legionella pneumophila human immunodeficiency virus immunomodulatory effects on human azithromycin pharmacokinetics and safety in patients, T-lymphocyte function in vitro, pharmacokinetics and intracellular con- 799 2643 centrations in infected and unin- M. tuberculosis roxithromycin fected guinea pigs, 217 inhibitory and bactericidal activities in protection against endotoxin-induced Legionella spp. vitro and in human macrophages, vascular leakage and neutrophil ceftriaxone 1161 accumulation in rat trachea, 1641 in vitro extracellular and intracellular pharmacokinetics Macrophage colony-stimulating factor activities, 200 safety in patients with human immuno- bronchoalveolar macrophages ceftriaxone-tazobactam deficiency virus, 799 effect of in vivo factor on fungistasis of in vitro extracellular and intracellular tuberculosis macrophages against C. neofor- activities, 200 activity in a murine model, 1476 mans, 2162 clavulanic acid Licochalcone A effect on anticryptococcal activity and in vitro extracellular and intracellular L. donovani synergy with fluconazole for killing, activities, 200 antileishmanial activity in hamsters, 2158 piperacillin 1339 peritoneal macrophages comparative activities against clinical L. major effect of in vivo factor on fungistasis of isolates, 144 antileishmanial activity in mice, 1339 macrophages against C. neofor- in vitro extracellular and intracellular P. falciparum mans, 2162 activities, 200 inhibition of in vitro growth, 1470 Malaria piperacillin-tazobactam P. yoelii ajoene protection of mice, 1470 in vivo activity against infections in ro- in vitro extracellular and intracellular Listeria monocytogenes dents, 337 activities, 200 amoxicillin Melarsamine hydrochloride (Cymelarsan) tazobactam inhibition of intracellular growth, 438 trypanosomiasis comparative activities against clinical Bay Y 3118 properties in aqueous solution, 1298 isolates, 144 eradication from infected mice and Meningitis Leishmania donovani L929 cells, 1501 C. albicans licochalcone A co-trimoxazole effects of antifungal therapy on inflam- activity in hamsters, 1339 inhibition of intracellular growth, 438 mation, sterilization, and histology, Leishmania major rifampin 83 licochalcone A inhibition of intracellular growth, 438 ceftriaxone activity in mice, 1339 sparfloxacin concentrations in cerebrospinal fluid of Leishmania mexicana inhibition of intracellular growth, 438 children receiving dexamethasone ketoconazole temafloxacin therapy, 1209 effect on lethal action of amphotericin inhibition of intracellular growth, 438 pneumococcal B on promastigotes, 1079 Listeria spp. effect on therapy of experimental peni- letters to the editor susceptibility testing cillin- and cephalosporin-resistant structure-function analysis of antimicro- activities of gentamicin, erythromycin, strains, 1320 tubule dinitroanilines, 1692 streptomycin, chloramphenicol, S. pneumoniae Leprosy ampicillin, sulfamethazine, cephalo- antibiotic therapy and acute outcome fusidic acid thin, penicillin G, and tetracycline, with strains intermediately suscep- clinical trial, 1651 1655 tible to broad-spectrum cephalo- multibacillary Lomefloxacin sporins, 918 international randomized study with trimethoprim-sulfamethoxazole Meropenem long-term follow-up of single ver- comparison for treatment of compli- Enterobacteriaceae sus combination chemotherapy, cated urinary tract infections, 1368 postantibiotic effect determined by five 2249 Lovastatin methods, 2583 Letters to the editor B. divergens pharmacokinetics carbapenems inhibition of in vitro development in patients with intra-abdominal infections, retain intermittent dosing, 159 human erythrocytes, 1144 151 ciprofloxacin P. falciparum Methicillin treatment of severe pneumonia, 1871 inhibition of in vitro development in mouse model imipenem human erythrocytes, 1144 treatment in a new experimental model treatment of severe pneumonia, 1871 of foreign body infection, 2047 L. mexicana Macrolides S. aureus resistance structure-function analysis of antimicro- Campylobacter spp. mechanisms of heteroresistance, 724 tubule evolution of susceptibilities, 1879 production of A and C variants of dinitroanilines, 1692 clarithromycin staphylococcal P-lactamase, 1649 M. avium immunomodulatory effects on human reassessment of number of auxiliary strains resistant to clarithromycin and T-lymphocyte function in vitro, genes essential for expression of azithromycin, 635 2643 high-level resistance, 2590 P. cepacia erythromycin S. epidermidis resistance analysis ofpenA gene, 407 protection against endotoxin-induced lack of mecA transcription in slime-neg- titles vascular leakage and neutrophil ative phase variants, 1251 new policy, 160 accumulation in rat trachea, 1641 Methotrexate Leukemia josamycin C. albicans roxithromycin immunomodulatory effects on human gene encoding resistance is multidrug randomized trial in patients, 465 T-lymphocyte function in vitro, resistance gene, 648 VOL. 38, 1994 SUBJECT INDEX xxi

Metronidazole Moraxella catarrhalis letter to the editor Bacteroides spp. broth microdilution strains resistant to clarithromycin and in vitro activities of drug and its hy- in vitro activities of 12 orally adminis- azithromycin, 635 droxy metabolite, 2106 tered antimicrobial agents against radiometric drug-inhibitor combination H. pyloni respiratory pathogens from U.S. techniques standardization of disk diffusion test medical centers in 1992 and 1993, definition of potential drug targets, and clinical significance for suscep- 2419 2287 tibility testing, 2357 Multivariate analysis rifabutin H. pylori resistance cephalothin effects alone and in combination with in vitro studies on stability and develop- comparative evaluation, 184 rifabutin on intracellular and extra- ment, 360 ciprofloxacin cellular replication, 2738 human necrotizing pancreatitis comparative evaluation, 184 Mycobacterium avium complex behavior, 830 daptomycin azithromycin M. tuberculosis comparative evaluation, 184 inhibition of binding to HT-29 intestinal bactericidal activity toward dormant gentamicin mucosal cells, 1200 cells, 2059 comparative evaluation, 184 beige mouse model Mezlocillin imipenem effectiveness of various antimicrobial human necrotizing pancreatitis comparative evaluation, 184 agents, 2521 behavior, 830 rifampin dexamethasone Miconazole comparative evaluation, 184 low doses as adjunctive therapy for dis- C albicans teicoplanin seminated infections in AIDS pa- in vivo pharmacokinetics and pharma- comparative evaluation, 184 tients, 2215 codynamics in human stratum cor- vancomycin ethambutol neum, 90 comparative evaluation, 184 activity in vitro and in macrophages, Minireviews Muramyl tripeptide phosphatidylethanol- 1838 aminoglycoside ototoxicity amide KRM 1648 proposed molecular and cellular mecha- K pneumoniae activity in vitro and in macrophages, nism, 2517 treatment of septicemia in normal and 1838 antibiotic resistance genes leukopenic mice, 147 paromomycin transfer between gram-positive and Murine cryptococcosis in vivo activity against susceptible and -negative bacteria, 1447 amphotericin B multidrug-resistant strains, 170 aspergillosis in vitro renal toxicity and in vivo thera- rifabutin strategies in prevention for immunosup- peutic efficacy associated with in- tralipid, 177 comparative in vivo activities, 234 pressed or neutropenic patients, inhibition of binding to HT-29 intestinal 911 Murine cytomegalovirus mucosal cells, 1200 C. pneumoniae nucleotide analogs analogs related to acyclovir and ganci- rifapentine antimicrobial susceptibility and therapy comparative in vivo activities, 234 of infections, 1873 clovir are effective against infection in BALB/c and severe combined roxithromycin central nervous system-immune system immunodeficient mice, 2165 activities alone and in combination with effect and immunomodulatory conse- Murine leukemia virus other drugs, 1433 quences of immune media- system zidovudine sparfloxacin tors on the 7 brain, impact of dosing schedule, 628 inhibition of binding to HT-29 intestinal psychoneuroendocrinology of stress and Mycobacterium avium mucosal cells, 1200 its immune consequences, 1 azithromycin Mycobacterium avium-M. intracellulare com- coagulase-negative staphylococci comparative activities against infection plex antimicrobial susceptibility, 2231 in beige mice, 1452 clarithromycin colonization resistance, 409 intermittent dosing for treatment of liposome encapsulated, efficacies of, 523 endotoxin release beige mice, 1721 ofloxacin clinical relevance of that induced by capreomycin liposome encapsulated, efficacies of, 523 antibiotics, 1211 pharmacokinetics, toxicity, and efficacy Mycobacterium fortuitum pharmaceutical industry of liposomal form in disseminated P-lactamases how an antibiotic drug is brought to mouse model, 2695 use of chromosomal class A to study market in the United States, 2679 clarithromycin substrates and inhibitory ,B-lactam quinolones comparative activities against infection compounds, 1608 gram-positive bacteria, 163 in beige mice, 1452 Mycobacterium intracellulare serum therapy effects alone and in combination with clarithromycin resistant animal models of infection and passive rifabutin on intracellular and extra- identifications of mutations in 23S antibody therapy, 1695 cellular replication, 2738 rRNA gene, 381 tetracyclines treatment and prevention of dissemi- Mycobactenum kansasii analogs whose primary target is not the nated infection in beige mice, bacterial ribosome, 637 azithromycin alone and in combination with in 1455 Minocycline dapsone, 2717 activities beige mice, high-performance liquid chromatography dapsone clarithromycin penetration of and bactericidal activity treatment and prevention of dissemi- activities in beige mice, 1455 within endothelial cells, 1059 nated infection in beige mice, Mycobacterium leprae S. aureus alone and in combination with cla- 2,2'-bipyridyl analogs comparison with vancomycin for treat- rithromycin, 2717 in vitro activities, 2908 ment of oxacillin-resistant experi- KRM 1648 ofloxacin mental endocarditis, 1515 activity alone or in combination with alone and in combination with dapsone MKC-442 ethambutol or clarithromycin in plus clofazimine, 662 human immunodeficiency virus type 1 beige mouse model of dissemi- sparfloxacin preclinical evaluation, 688 nated infection, 1844 clinical trial for lepromatous leprosy, 61 xxii SUBJECT INDEX ANTIMICROB. AGENTS CHEMOTHER.

Mycobacterium malmoense older tetracyclines, 2628 protection by ceftriaxone, 750 azithromycin Mycoplasma pneumoniae Neurotoxicity activities in beige mice, 1455 glycylcyclines artemisinin analogs clarithromycin susceptibility compared with that to in vitro studies, 1813 activities in beige mice, 1455 older tetracyclines, 2628 5-Nitroimidazole Mycobactenium simiae macrolides Bacteroides spp. azithromycin in vitro and in vivo activities, 790 nucleotide sequence analysis, 1047 activities in beige mice, 1455 sparfloxacin Nocardia spp. clarithromycin in vitro and in vivo activities, 738 erythromycin activities in beige mice, 1455 Myeloperoxidase inactivation, 2197 activity in murine model of dissemi- human immunodeficiency virus type 1 midecamycin nated infection, 2676 virucidal effect on T cells, 969 inactivation, 2197 clarithromycin plus ethambutol rokitamycin activity in murine model of dissemi- Naeglena fowleri inactivation, 2197 nated infection, 2676 amoebicins Norfloxacin ofloxacin characterization and biological activity P. aeruginosa activity in murine model of dissemi- against, 1314 effects on in vitro adhesion and survival nated infection, 2676 Nafcillin of strain AK1 on urinary catheters, Mycobacterium smegmatis high-performance liquid chromatography 1490 fluoroquinolone resistant penetration of and bactericidal activity sucralfate characterization of mutations involved within endothelial cells, 1059 effect on absorption, 248 in resistance, 1991 Naftifine susceptibility testing human polymorphonuclear leukocytes Ofloxacin isoniazid and peroxides, 1829 effects of allylamine antifungal drugs on bioavailabilities Mycobacterium spp. selected functions, 2605 effect of enteral feeding with Ensure, aminocyclitol Neisseria gonorrhoeae 2101 in vitro susceptibilities, 134 azithromycin C. pneumoniae aminoglycosides susceptibility of isolates from women in vitro activities, 1402 in vitro susceptibilities, 134 with pelvic inflammatory disease, cancer quinolones 1688 susceptibilities of isolates from patients, in vitro susceptibilities, 134 cefoxitin 848 rifampin resistant susceptibility of isolates from women enteric fever characterization in pathogenic strains, with pelvic inflammatory disease, comparison with ceftriaxone for short- 2380 1688 course treatment, 1716 RNA amplification ceftriaxone M. avium-M. intracellulare complex assessment of viability, 1959 susceptibility of isolates from women liposome encapsulated, efficacies of, 523 streptomycin resistance with pelvic inflammatory disease, M. leprae role of permeability barriers, 238 1688 alone and in combination with dapsone tetracycline resistance clindamycin plus clofazimine, 662 acquisition of determinants, 1408 susceptibility of isolates from women M. simiae Mycobacterium tuberculosis with pelvic inflammatory disease, activity in murine model of dissemi- fluoroquinolone resistant 1688 nated infection, 2676 cloning and nucleotide sequences of doxycycline oral absorption gyrA and gyrB genes, 773 susceptibility of isolates from women effects of administration with alumi- KRM-1648 with pelvic inflammatory disease, num, 2510 activity of the new benzoxazinorifamy- 1688 P. aeruginosa cin in a murine model, 2245 gentamicin effects on in vitro adhesion and survival levofloxacin susceptibility of isolates from women of strain AK1 on urinary catheters, inhibitory and bactericidal activities in with pelvic inflammatory disease, 1490 vitro and in human macrophages, 1688 pharmacokinetics 1161 quinolone resistant kinetics of ofloxacin and metabolites metronidazole in vitro resistance in penicillinase-pro- after single intravenous infusion, bactericidal activity toward dormant ducing strains in Hawaii, 2200 1849 cells, 2054 susceptibility testing respiratory tract infections paromomycin persistence of strains with decreased effective monitoring of concentrations in vivo activity against susceptible and susceptibilities to ciprofloxacin and in saliva of patients, 1140 multidrug-resistant strains, 170 ofloxacin in Cleveland, Ohio, 2194 Staphylococcus spp. PCR strains isolated in Surbaya, Indonesia, prophylactic efficacy in an experimental rpoB, 805 2530 wound infection, 1325 streptomycin resistance strains representing five distinct resis- sucralfate mapping of mutations, 228 tance phenotypes, 155 effect on absorption, 248 Mycobactenium xenopi Neisseria meningitidis urinary tract infections azithromycin rifampin resistant studies with women comparing 3-day activities in beige mice, 1455 molecular characterization, 1256 regimens, 1176 clarithromycin susceptibility testing X. maltophilia activities in beige mice, 1455 decreased susceptibility to penicillin G susceptibilities of 123 strains, 369 Mycophenolic acid and Tet M plasmids in genital and Y pestis Epstein-Barr virus anorectal isolates, 1661 treatment of murine infection, 481 effect on infection of human B lympho- Nephrotoxicity OPC-17116 cytes, 126 daptomycin C. pneumoniae Mycoplasma hominis gentamicin induced; attenuation of, in vitro activities, 1402 glycylcyclines 1027 respiratory tract infections susceptibility compared with that to tobramycin evaluation against important pathogens, VOL. 38, 1994 SUBJECT INDEX xxiii

2340 rpoB, 805 Pharmacodynamics Oral penems S. dysenteriae piperacillin SY5555 detection of 4-quinolone resistance mu- piperacillin-resistant and -susceptible in vivo antibacterial stability and 3-lac- tation in gyrA gene of type 1, 2488 organisms in an in vitro model of tamase stability, 1974 PD 131628 infection, 2351 Otitis media X maltophilia piperacillin-tazobactam cefprozil susceptibilities of 123 strains, 369 piperacillin-resistant and -susceptible penetration into middle ear fluid of pa- PD 138312 organisms in an in vitro model of tients, 2210 X maltophilia infection, 2351 Outer membrane permeabilization susceptibilities of 123 strains, 369 S. aureus antimicrobial cationic peptides PD 140248 levofloxacin, ofloxacin, and ciprofloxa- improvement, along with that of lipopo- X maltophilia cin, alone and in combination with lysaccharide-binding activity, by susceptibilities of 123 strains, 369 rifampin, in methicillin-susceptible C-terminal modification, 2311 Pefloxacin and -resistant strains, 2702 Oxacillin absorption Pharmacokinetics S. aureus resistance effect of antacid containing magnesium amikacin minocycline versus vancomycin for and aluminum in study with hu- comparison of two therapeutic regimens treatment of experimental endocar- mans, 1129 for P. aeruginosa, 981 ditis, 1515 high-pressure liquid chromatography aminoglycosides mupirocin resistance among consecutive determination of concentration in mes- comparison with Asian, Hispanic, and isolates at a university hospital, enteric lymph nodes, 632 Caucasian patients by using popu- 1664 human necrotizing pancreatitis lation pharmacokinetic methods, S. pneumoniae resistance behavior, 830 2073 genetics of oxacillin resistance in clini- mechanism of renal elimination effect of fever and changes in glomeru- cal isolates, 49 effect of antacid containing magnesium lar filtration rate, 620 Oxetanocin G and aluminum in study with hu- amoxicillin hepatitis B virus mans, 1129 simulation in humans for prevention of effect on DNA synthesis by virions, 707 metabolism streptococcal endocarditis in rats, Oxyrase agar dilution effect of antacid containing magnesium 2846 azithromycin and aluminum in study with hu- amphotericin B comparison with reference agar dilution mans, 1129 safety of unilamellar liposomal formula- method for susceptibility testing of S. marcescens tion in rabbits, 713 anaerobes, 211 in vivo activities in an experimental azithromycin clarithromycin model of endocarditis, 883 L. pneumophila in guinea pigs, 217 comparison with reference agar dilution Penciclovir ceftazidime method for susceptibility testing of duck hepatitis B virus killing of P. aeruginosa, 931 anaerobes, 211 in vitro activity, 719 ceftriaxone erythromycin Penicillin patients with typhoid fever, 2415 comparison with reference agar dilution S. pneumoniae resistance plasma exchange in polyarteritis nodosa method for susceptibility testing of genetics of oxacillin resistance in clini- patients, 1519 anaerobes, 211 cal isolates, 49 ciprofloxacin roxithromycin in vitro selective antibiotic concentra- strains of S. pneumoniae, S. aureus, and comparison with reference agar dilution P. aeruginosa for which MICs are tions of ,-lactams, 122 2730 method for susceptibility testing of treatment of experimental endocarditis, similar, anaerobes, 211 1103 (2'R,5'S)-cis-5-fluoro-1-[2-(hydroxy- Penicillin G methyl)-1,3-oxathiolan-5-yl] cytosine Paromomycin oral bioavailability and metabolism in B. burgdorferi mice and cynomolgus monkeys, C. parvum in 1567 evaluation of curative anticryptospo- effectiveness of treatment mice, 2722 pneumococci ridial in a dexamethasone- dapsone activity activities time-kill treated rat model, 1681 antipneumococcal by safety of weekly doses for prevention of methodology, 2065 M. avium complex pneumocystis pneumonia, 1580 in vivo activity against susceptible and Penicillin-binding proteins dapsone plus pyrimethamine multidrug-resistant strains, 170 P-lactams safety of weekly doses for prevention of M. tuberculosis study and purification, 973 pneumocystis pneumonia, 1580 in vivo activity against susceptible and chemiluminescence dideoxyinosine multidrug-resistant strains, 170 study and purification, 973 neonatal pigtailed macaques, 787 Pasteurella haemolytica digoxigenin-ampicillin conjugate transplacental studies with pigtailed ma- equilibrium dialysis detection by chemiluminescence, 330 caques, 781 effects of localized infection on erythro- E. coli fialuridine mycin-binding properties of bovine regulation by rpoS during transitions in initial assessment by radioimmunoassay alpha-i-acid glycoprotein, albumin, growth states, 205 after single oral doses to healthy serum, and tissue chamber fluids, E. faecium volunteers, 2134 2392 correlation of overproduction of low- FK-037 PCR affinity protein with ampicillin re- pharmacokinetics and distribution in Acinetobacter spp. sistance, 1980 tissue of the new cephalosporin, detection of aac(6')-I gene in amikacin- Pentamidine isethionate 2369 resistant strains, 2925 S. cerevisiae fleroxacin E. faecalis effects, 1123 effects of a fat- and calcium-rich break- analysis and direct DNA sequencing of Pharmaceutical industry fast, 499 gyrA mutations associated with minireviews single doses to bacteremic patients, fluoroquinolone resistance, 2091 how an antibiotic drug is brought to 1219 M. tuberculosis market in the United States, 2679 fluconazole 3odv SUBJECT INDEX ANTIMICROB. AGENTS CHEMOTHER.

validation of animal model used to Phytosterols comparative activities of penicillin G, measure drug concentrations in P. carinji RP 59500, erythromycin, sparfloxa- cerebrospinal fluid, 2111 presence, 2534 cin, ciprofloxacin, and vancomycin, foscarnet Piperacillin 2065 clinical outcome of cytomegalovirus ret- Legionella spp. Pneumococcus spp. initis, 1190 comparative activities against clinical penicillin resistant genaconazole isolates, 144 susceptibilities to eight 1-lactams, 2905 healthy men after oral and intravenous in vitro extracellular and intracellular penicillin susceptible administration, 2758 activities, 200 susceptibilities to eight P-lactams, 2905 GLQ223 pharmacokinetics Pneumocystis carinji safety, activity, and pharmacokinetics in single doses to children, 2817 albendazole patients with AIDS and AIDS-re- Piperacillin-tazobactam inhibition of proliferation in inoculated lated complex, 260 K pneumoniae immunosuppressed mice, 1834 human immunodeficiency virus different ratios for treatment of experi- 3-1,3-glucan-specific antibody zidovudine phosphorylation in periph- mental meningitis, 195 use to study cyst wall, 2258 eral blood mononuclear cells of Legionella spp. dapsone patients, 1541 in vitro extracellular and intracellular levels in serum during once-weekly dos- itraconazole activities, 200 ing, 1197 bioassay using hydroxyitraconazole stan- penetration imidazole dards, 1561 cancellous and cortical bone tissues, resistance, 1859 levofloxacin 905 iron chelators safety in patients with human immuno- in bronchial secretions after multiple use as therapeutic agents, 997 deficiency virus, 799 doses to intensive care patients, L-693,989 meropenem 2780 aerosolized form for prophylaxis in rats, patients with intra-abdominal infections, Plasmodium falciparum 1397 151 5-fluoroorotate resistance L-733,560 norfloxacin nicotinate selection and characterization of cells, effects of the pneumocandin Bo analog, effect of lactation on single doses to 2871 2258 ewes, 2336 acridine alkaloids ornithine decarboxylase ofloxacin in vitro activities, 1169 implications for therapy, 2545 kinetics of ofloxacin and metabolites antimalarial endoperoxides phytosterols after single intravenous infusion, reaction with specific parasite proteins, presence, 2534 1849 1854 pyrimethamine penicillin bisbenzylisoquinolone alkaloids levels in serum during once-weekly dos- concentrations after increased doses of in vitro activities, 96 ing, 1197 benzathine penicillin G for preven- chloroquine resistant topoisomerases tion of secondary rheumatic fever, enhancement of susceptibility by neuro- selective inhibition compared with that 1203 nal monoamine reuptake inhibi- of topoisomerases from mamma- 9-(2-phosphonylmethoxyethyl)adenine tors, 1419 lian cells, 1890 bioavailabilities in cynomolgus mon- fluoroquinolones Pneumocystis carinii pneumonia keys, 365 in vitro activities, 1169 guanylhydrazones piperacillin ICI D1694 therapy of immunosuppressed rats, single doses to children, 2817 susceptibility, 476 2572 polyoxometalates licochalcone A Polyaminopropyl biguanide inhibition of in vitro growth, T5 Acanthamoeba spp. rats, 504 lovastatin quantitation and kinetics of killing, 886 sparfloxacin inhibition of in vitro development in Polymyxin B influence of fecal flora of healthy male human erythrocytes, 1144 nonapeptide volunteers, 455 simvastatin experimental gram-negative infections patients with renal impairment, 733 inhibition of in vitro development in in mice, 374 spiramycin human erythrocytes, 1144 Polymyxin B sulfate transplacental passage and distribution thymidine agar plate diffusion in tissue of rhesus monkey fetus, susceptibility, 476 effects of agars on determination of po- 1922 Plasmodium vivax tency, 2665 tazobactam rifampin Polyoxometalates single doses to children, 2817 antimalarial effects, 511 pharmacokinetics ticarcillin-clavulanic acid Plasmodium yoelii rats, 504 preterm neonates with presumed sepsis, licochalcone A Prophylaxis 2024 protection of mice, T5 gram positive tobramycin Pneumocandins randomized trial with patients undergo- effects of polyaspartic acid in two L-733,560 ing bone marrow transplantation, strains of rat, 79 increased antifungal activity due to en- 576 zidovudine hanced inhibition of cell wall syn- standard effect of dipyridamole in asymptomatic thesis, 2750 randomized trial with patients undergo- human immunodeficiency virus- Pneumococci ing bone marrow transplantation, infected subjects, 1036 susceptibility testing 576 Phosphonium salts comparison of WY-49605 with penicil- Pseudomonas aeruginosa dimethyl and trimethyl substituted lin G, amoxicillin, amoxicillin-cla- amikacin synthesis and antimicrobial activity, 945 vulanate, cefixime, cefaclor, cefpo- pharmacokinetic and pharmacodynamic 9-(2-Phosphonylmethoxyethyl)adenine doxime, cefuroxime, and cefdinir approach for comparing two thera- pharmacokinetics with 187 penicillin-susceptible and peutic regimens, 981 bioavailabilities in cynomolgus mon- -resistant strains, 2902 azithromycin keys, 365 time-kill methodology in vitro exoenzyme-suppressing activi- VOL. 38, 1994 SUBJECT INDEX xxv

ties, 528 B. fragilis ants expressing multiple resistance- azlocillin comparative activities of eight agents, engendering amino acid substitu- time-survival studies for quantifying 1442 tions, 1404 effects, 1271 Bay Y 3118 Rhinovirus ,B-lactam resistant eradication of L. monocytogenes from soluble intercellular adhesion molecule 1 role of efflux pumps, 1742 infected mice and L929 cells, 1501 in vitro selection of relatively resistant ,-lactamases biphenylacetic acid strains, 66 sequence analysis of PER-1 and com- possible intermolecular interaction in- Ribavirin parison with class A P-lactamases, hibits aminobutyric acid receptor subacute sclerosing panencephalitis virus 104 sites, 2323 effect on infections in hamsters, 653 biofilms Campylobacter spp. Rifabutin biofilm accumulation model that pre- evolution of susceptibilities, 1879 M. avium complex dicts antibiotic resistance, 1052 coryneforms comparative in vivo activities, 234 ceftazidime comparative activities of eight new inhibition of binding to HT-29 intestinal killing during infusion in an in vitro agents, 1439 mucosal cells, 1200 pharmacokinetic model, 931 DU-6859a mouse tuberculosis chloramphenicol resistant in vitro and in vivo antimycobacterial effectiveness alone or in combination role of efflux pumps, 1732 activities, 2877 with isoniazid in preventive ther- ciprofloxacin E. coli apy, 2346 effects on in vitro adhesion and survival comparison of inhibition of topoisomer- toxoplasmosis of strain AK1 on urinary catheters, ase IV with DNA gyrase inhibition, murine models of infection, 570 1490 2623 Rifabutin-isoniazid investigation of penetration into bio- gram-positive bacteria mouse tuberculosis films, 2125 minireview, 163 effectiveness in preventive therapy, 2346 serum bactericidal activities in 30 pa- L. monocytogenes Rifampin tients, 837 eradication from infected mice and high-performance liquid chromatography imipenem L929 cells by Bay Y 3118, 1501 penetration of and bactericidal activity pharmacodynamic effects of subinhibi- minireview within endothelial cells, 1059 an 163 tory concentrations in in vitro gram-positive bacteria, L. monocytogenes dynamic model, 1416 Mycobacterium spp. in vitro susceptibilities, 134 inhibition of intracellular growth, 438 norfloxacin multivariate analysis on in vitro adhesion and survival N. gonorrhoeae effects evaluation, 184 of strain AK1 on urinary catheters, in vitro resistance in penicillinase-pro- comparative 1490 ducing strains in Hawaii, 2200 Mycobacterium spp. norfloxacin resistant OPC-17116 characterization in pathogenic strains, role of efflux pumps, 1732 in vitro activities against C. pneu- 2380 ofloxacin moniae, 1402 N. meningitidis resistance effects on in vitro adhesion and survival P. aeruginosa molecular characterization, 1256 of strain AK1 on urinary catheters, mechanisms of high-level resistance in P. vivax 1490 urinary tract isolates, 1466 antimalarial effects, 511 PAO1 resistance loci S. pneumoniae cloning and nucleotide sequence of mediation by norA and relationship to therapy of experimental meningitis in DNA gyrase gyrA gene from strain flqB, locus on S. aureus chromo- rabbits, 1186 and quinolone-resistant isolates, some, 1345 tuberculosis 1944 tuftsin-bearing liposomes in treatment quinolones Radioimnmunoassay of mice, 588 mechanisms of high-level resistance in zalcitabine Rifamycin urinary tract isolates, 1466 determination of levels in human KRM-1648 tetracycline resistant plasma, urine, and cerebrospinal in vitro and in vivo activities, 1118 role of efflux pumps, 1732 fluid, 2763 KRM-1657 tobramycin Radioimmunoassays in vitro and in vivo activities, 1118 pulmonary retention of free and lipo- fialuridine Rifapentine some-encapsulated forms after ad- initial assessment of pharmacokinetics M. avium complex ministration in rats, 1090 after single oral doses to healthy comparative in vivo activities, 234 time-survival studies for quantifying volunteers, 2134 Roxithromycin effects, 1271 zidovudine bone marrow transplantation Pseudomonas cepacia evidence of alkaline phosphatase inter- randomized trial in patients receiving letters to the editor ference, 2689 fluoroquinolone prophylaxis, 465 analysis ofpenA gene, 407 Recombinant virus assay Pyrimethamine human immunodeficiency virus type 1 leukemia assessment of drug susceptibility iso- randomized trial in patients, 465 P. carinii inflam- levels in serum during once-weekly dos- lates, 23 lipopolysaccharide-induced airway ing, 1197 Respiratory synctial virus mation intranasal monoclonal immunoglobulin A inhibition of vascular leakage and neu- Quinolones protection against upper and lower re- trophil accumulation in rat trachea, A. salmonicida spiratory tract infections in mice, 1641 gyrA mutations in isolates of the fish 2785 M. avium complex pathogen, 2460 Respiratory syncytial virus activities alone and in combination with AM-1155 sulfonic acid polymers other drugs, 1433 in vitro activity, 594 in vitro and in vivo inhibition, 256 Oxyrase agar dilution anti-M. avium activities Reverse transcriptase inhibitors comparison with reference agar dilution predicted active structures and mecha- human immunodeficiency virus type 1 method for susceptibility testing of nistic considerations, 1794 susceptibilities of enzyme and viral vari- anaerobes, 211 xxvi SUBJECT INDEX ANTIMICROB. AGENTS CHEMOTHER.

RP 59500 Soluble intercellular adhesion molecule type endocarditis endocarditis 1 activities of teicoplanin, vancomycin, in vivo activities and penetration of two rhinovirus and alone components, 432 gentamicin and in com- activities compared with those of chi- bination in an in vitro pharmacody- Rufloxacin meric soluble intercellular adhesion namic model, 2034 MF 922 molecule type 1/immunoglobulin A resistance in vitro antimycoplasmal activities, 2651 fluoroquinolone molecule, 1425 in vivo selection of a mutant during spectrum of activity against reference pefloxacin therapy, 1149 Saccharomyces cerevisiae strains and field isolates, 1413 methicillin resistance 22,23-epoxy-2-aza-2,3-dihydrosqualene Sparfloxacin altered of inhibition of sterol synthesis in conjunc- production penicillin-binding antagonism protein 2a can affect phenotypic tion with corresponding N-oxide, GABAA receptor of rat vagus nerve, 1904 expression, 2568 1356 comparison of tests for detection in a bleomycin C. pneumoniae clinical microbiology laboratory, potentiation of cytotoxicity, 1615 in vitro activities, 1402 345 cytosine protective effects in experimental pneu- methicillin resistant uptake affected by fenpropimorph, 1004 monia in 1757 PDR5 leukopenic mice, comparison of teicoplanin, teicoplanin- ceftriaxone rifampin, and vancomycin for treat- loss of function mutation in multiple comparative evaluation for treatment of ment and prophylaxis of experi- drug resistance gene causes reduc- experimental endocarditis due to mental foreign body infection, 1703 tion in chloramphenicol efflux, penicillin-susceptible and -resistant mechanisms 2492 of heteroresistance, 724 streptococci, 2683 production of A and C variants of pentamidine isethionate L. monocytogenes staphylococcal 3-lactamase, 1649 effects, 1123 inhibition of intracellular growth, 438 reassessment pentamidine resistance of number of auxiliary M. avium complex genes essential for expression of characterization of the PNT1 gene, inhibition of binding to HT-29 intestinal 2850 high-level resistance, 2590 mucosal cells, 1200 mupirocin uracil M. resistance leprae molecular characterization of gene en- uptake affected by fenpropimorph, 1004 clinical trial for lepromatous leprosy, 61 coding resistance of strain J2870, Saperconazole M. pneumoniae 1205 amphotericin B in vitro and in vivo activities, 738 nonradioisotopic single-strand conforma- efficacy and interactions in therapy of penetration tion polymorphism analysis murine disseminated candidiasis, human brain tissue, 1356 detection 371 of novel mutations in gyrA pharmacokinetics gene, 428 Serratia marcescens influence of fecal flora of f3-lactamases healthy male oxacillin resistant volunteers, 455 minocycline versus vancomycin for cloning and sequence analysis of gene patients with renal impairment, 733 treatment of experimental endocar- for Sme-1 from strain S6, 1262 pneumococci ditis, 1515 ciprofloxacin antipneumococcal activities by time-kill resistance in vivo activities in an experimental mupirocin among consecutive methodology, 2065 isolates at a university hospital, model of endocarditis, 883 Spiramycin 1664 metallo ,B-lactamases pharmacokinetics pharmacodynamics molecular characterization, 71 transplacental passage and distribution pefloxacin levofloxacin, ofloxacin, and ciprofloxa- in tissue of rhesus monkey fetus, cin, alone and in combination with in vivo activities in an experimental 1922 rifampin, in methicillin-susceptible model of endocarditis, 883 T. gondii and -resistant strains, 2702 Shigella dysenteriae effectiveness for treatment of congenital platelet microbicidal protein PCR infections in rhesus monkeys, 1930 in vitro detection of 4-quinolone resistance correlates with endo- resistance mu- T. gondii resistance carditis source, 729 tation in gyrA gene of type 1, 2488 comparison of mutants, 31 quinolone resistance Shigella spp. Staphylococcus aureus traveler's diarrhea mutations in the DNA gyrase gyrA and P-lactams gyrB genes, 2014 antimicrobial resistance of isolates, comparison with glycopeptides in treat- strain J2870 2668 ment of subcutaneous abscesses, molecular Simian immunodeficiency virus characterization of gene en- 1023 coding high-level mupirocin resis- U-75875 cephalosporin-rifampin tance, 1205 effect on infection in rhesus monkeys, failure of time-kill synergy studies to 1277 teicoplanin predict in vivo antagonism of com- role of tolerance in treatment and Simvastatin binations, 2191 pro- B. divergens phylaxis of experimental endocardi- inhibition ciprofloxacin tis, 487 of in vitro development in serum bactericidal activities in 30 pa- vancomycin human erythrocytes, 1144 tients, 837 efficacies of different P. falciparum clinafloxacin dosing regimens determined with a dynamic in vitro inhibition of in vitro development in bactericidal activities, 1868 human erythrocytes, 1144 model, 2480 daptomycin role of tolerance in treatment and Sinefungin role of tolerance in pro- Cryptosporidium treatment and pro- phylaxis of experimental endocardi- spp. phylaxis of experimental endocardi- tis, 487 studies with immunodeficient mouse tis, 487 Staphylococcus epidermidis model, 865 DNA sequencing clarithromycin Soluble intercellular adhesion molecule 1 detection of novel rhinovirus mutations in gyrA interaction between antibiotic and bio- gene, 428 films, 138 in vitro selection of relatively resistant DU-6859a strains, 66 methicillin resistant bactericidal activities, 1868 lack of mecA transcription in slime-neg- VOL. 38, 1994 SUBJECT INDEX xxvii

ative phase variants, 1251 with meningitis, 2655 10 antimicrobial agents against strains Staphylococcus spp. in vitro selective antibiotic concentra- isolated from feces of pediatric cefazolin tions of 1B-lacLams, 122 patients, 2917 prophylactic efficacy in experimental treatment of experimental endocarditis, Candida spp. wound model, 1325 1103 fluconazole, 1422 ciprofloxacin penicillin susceptible clarithromycin prophylactic efficacy in experimental genetics of oxacillin resistance in clini- C. pneumoniae isolates from children wound model, 1325 cal isolates, 49 with pneumonia, 1588 fluoroquinolones rifampin coagulase-negative staphylococci dissociated resistance among strains, therapy of experimental meningitis in minireview, 2231 2095 rabbits, 1186 D. fragilis ATCC 30948 methicillin resistant vancomycin iodoquinol, 1157 dissemination of DNA sequences, 438 susceptibilities of penicillin-susceptible metronidazole, 1157 ofloxacin and -resistant isolates, 898 paromomycin, 1157 prophylactic efficacy in experimental Streptococcus pyogenes tetracycline, 1157 wound model, 1325 broth microdilution E. coli trimethoprim resistant in vitro activities of 12 orally adminis- peroxides and isoniazid, 1829 possible role of IS257 in dissemination tered antimicrobial agents against erythromycin and expression of high and low respiratory pathogens from U.S. C. pneumoniae isolates from children levels of resistance, 2238 medical centers in 1992 and 1993, with pneumonia, 1588 vancomycin 2419 prophylactic efficacy in experimental Streptogramins fluconazole wound model, 1325 RP 59500 Candida spp., 1422 Streptococcus pneumoniae in vivo activities and penetration of two improved medium, 45 biapenem components, 432 foscarnet susceptibilities of penicillin-susceptible Streptomyces ambofaciens correlation between response and result and -resistant isolates, 898 fluoroquinolones for herpes simplex virus isolates, broth microdilution stimulation of genetic instability and 1246 in vitro activities of 12 orally adminis- associated large genomic rear- H. influenzae tered antimicrobial agents against rangements, 1985 susceptibilities of Canadian isolates and respiratory pathogens from U.S. Streptomyces spp. characterization of their P-lactama- medical centers in 1992 and 1993, tetracycline resistance ses, 1678 2419 acquisition of determinants, 1408 Listeria spp. cefepime Streptomyces viridodiastaticus activities of gentamicin, erythromycin, susceptibilities of penicillin-susceptible subsp. "littus" LL-31F508 streptomycin, chloramphenicol, and -resistant isolates, 898 mechanistic studies and biological activ- ampicillin, sulfamethazine, cephalo- cefotaxime ity of bioxalomycin a-2,1808 thin, penicillin G, and tetracycline, susceptibilities of penicillin-susceptible Streptomycin 1655 and -resistant isolates, 898 Mycobactenum sp. resistance M. smegmatis cefpirome role of permeability barriers, 238 peroxides and isoniazid, 1829 susceptibilities of penicillin-susceptible Subacute sclerosing panencephalitis virus N. gonorrhoeae and -resistant isolates, 898 ribavirin persistence of strains with decreased ceftazidime effect on infections in hamsters, 653 susceptibilities to ciprofloxacin and susceptibilities of penicillin-susceptible Sucralfate ofloxacin in Cleveland, Ohio, 2194 and -resistant isolates, 898 ketoconazole strains isolated in Surbaya, Indonesia, ceftriaxone in vitro analysis of interaction, 319 2530 efficacy against penicillin-susceptible in vivo interaction in healthy volunteers, strains representing five distinct resis- and -resistant strains in a mouse 326 tance phenotypes, 155 pneumonia model, 1953 norfloxacin N. meningitidis susceptibilities of penicillin-susceptible effect on absorption, 248 decreased susceptibility to penicillin G and -resistant isolates, 898 ofloxacin and Tet M plasmids in genital and FK 037 effect on absorption, 248 anorectal isolates, 1661 susceptibilities of penicillin-susceptible Sulbactam pneumococci and -resistant isolates, 898 P-lactamases comparison of WY-49605 with penicil- imipenem comparative activities, 767 lin G, amoxicillin, amoxicillin-cla- susceptibilities of penicillin-susceptible Sulfamethoxazole-trimethoprim vulanate, cefixime, cefaclor, cefpo- and -resistant isolates, 898 C. albicans doxime, cefuroxime, and cefdinir meningitis colonization of gastrointestinal tracts of with 187 penicillin-susceptible and antibiotic therapy and acute outcome mice, 602 -resistant strains, 2902 with strains intermediately suscep- Susceptibility testing X tible to broad-spectrum cephalo- A. baumannii maltophilia clinical isolates from Singapore, 2502 susceptibilities of 123 strains tested by sporins, 918 five methods, 2317 meropenem A. haemolyticum, 142 susceptibilities of penicillin-susceptible acyclovir Y enterocolitica and -resistant isolates, 898 correlation between response and result pathogenic strains isolated in Canada oxacillin resistant for herpes simplex virus isolates, from 1972 to 1990, 2121 genetics of oxacillin resistance in clini- 1246 Synergy cal isolates, 49 B. fragilis 1-lactams penicillin resistant longitudinal study with five agents in glycopeptide-resistant strains of E. fae- experimental respiratory infections in three medical centers, 2276 cium, 824 neutropenic rats, 608 C. albicans glycopeptides in vitro killing activities of antibiotics in improved medium for fluconazole, 45 glycopeptide-resistant strains of E. fae- cerebral spinal fluid from children Campylobacter spp. cium, 824 xxviii SUBJECT INDEX ANTIMICROB. AGENTS CHEMOTHER.

Tazobactam Torulopsis glabrata Trimethoprim-sulfamethoxazole 1-lactamases amphotericin B H. ducreyi resistance comparative activities, 767 treatment of disseminated infection, emergence in Rwanda, 1647 Legionella spp. 1604 lomefloxacin comparative activities against clinical D0870 comparison for treatment of compli- isolates, 144 treatment of disseminated infection, cated urinary tract infections, 1368 pharmacokinetics 1604 Trypanosoma brucei rhodesiense single doses to children, 2817 Toxicity DL-a-difluoromethylornithine Teicoplanin amphotericin B deoxycholate combination chemotherapy of drug- E. faecium influence of diet, 963 resistant infections in mice, 563 activities alone and in combinations, nephrotoxicity trypanocides 1225 daptomycin may attenuate that of to- combination chemotherapy of drug- hematologic malignancies bramycin by electrostatic complex- resistant infections in mice, 563 effects in initial empirical antibiotic reg- ation, 742 Tuberculosis imen for febrile, neutropenic pa- zidovudine rifampin tients, 2041 quantitative relationships between expo- tuftsin-bearing liposomes in treatment multivariate analysis sure and efficacy, 1726 of mice, 588 comparative evaluation, 184 Toxoplasma gondii Tumor necrosis factor S. aureus artemisinin ether K pneumoniae drug alone, teicoplanin-rifampin, and in vitro effects, 1392 influence of antimicrobial therapy on vancomycin for treatment and pro- azithromycin kinetics in experimental endocardi- phylaxis of experimental foreign localization in infected cells, 1620 tis, 1017 body infection by methicillin-resis- lipopolysaccharide-stimulated macro- azithromycin resistance phages tant strains, 1703 comparison of mutants, 31 role of tolerance in treatment and pro- modulation of secretion by unilamellar clindamycin resistance liposomes, 2671 phylaxis of experimental endocardi- comparison of mutants, 31 tis, 487 peripheral benzodiazepine receptor li- cycloguanil gands Temafloxacin in vitro effects, 1392 ciprofloxacin effect on activity in thioglycolate-treated cycloguanil-sulfadiazine mice, 812 effects on T-lymphocyte function, 879 in vitro effects, 1392 L. monocytogenes epiroprim Ureaplasma urealyticum inhibition of intracellular growth, 438 activity alone and in combination with glycylcyclines Terbinafine dapsone, 1803 susceptibility compared with that to human polymorphonuclear leukocytes mefloquine older tetracyclines, 2628 effects of allylamine antifungal drugs on in vitro effects, 1392 selected functions, 2605 Valaciclovir primaquine phosphate human immunodeficiency virus Tetracycline in vitro effects, 1392 E. faecalis resistance phase I trial in patients with advanced quinine sulfate disease, 1534 presence of Listeria gene tet(S), 2330 in vitro 1392 resistance effects, Vancomycin spiramycin tetA(B) gene and substrate specificity of hematologic malignancies effectiveness for treatment of congenital effects in initial antibiotic tetracycline efflux pump, 857 empirical reg- Tetracyclines infections in rhesus monkeys, 1930 imen for febrile, neutropenic pa- glycylcyclines spiramycin resistance tients, 2041 inhibition of protein synthesis occurring comparison of mutants, 31 high-performance liquid chromatography trifluoperazine hydrochloride penetration of and bactericidal activity on tetracycline-resistant, TetM- protected ribosomes, 1658 in vitro effects, 1392 within endothelial cells, 1059 verapamil multivariate analysis minireview comparative evaluation, 184 analogs whose primary target is not the in vitro effects, 1392 Toxoplasmosis penetration bacterial ribosome, 637 mediastinal and cardiac tissues in hu- Thymidine rifabutin murine models of infection, 570 mans, 396 P. falcipanrm pneumococci susceptibility, 476 Triazoles antipneumococcal activities by time-kill Ticarcillin-clavulanic acid D0870 methodology, 2065 pharmacokinetics in vitro activity against C. albicans iso- S. aureus preterm neonates with presumed sepsis, lates from oral cavities of patients comparison with minocycline for treat- 2024 infected with human immunodefi- ment of oxacillin-resistant experi- Tobramycin ciency virus, 2553 mental endocarditis, 1515 nephrotoxicity murine trichosporonosis comparison with teicoplanin and teico- attenuation by daptomycin, 742 efficacy compared with those of ampho- planin-rifampin for treatment and protection by ceftriaxone, 750 tericin B and amphotericin B-tria- prophylaxis of experimental foreign P. aeruginosa zoles, 2541 body infection by methicillin-resis- pulmonary retention of free and lipo- Tribactams tant strains, 1703 some-encapsulated forms after ad- GV104326 efficacies of different dosing regimens ministration in rats, 1090 in vitro activities against gram-positive, determined with a dynamic in vitro time-survival studies for quantifying gram-negative, and anaerobic bac- model, 2480 effects, 1271 teria, 2362 role of tolerance in treatment and pro- pharmacokinetics Trimethoprim phylaxis of experimental endocardi- effects of polyaspartic acid in two Staphylococcus sp. resistance tis, 487 strains of rat, 79 possible role of IS257 in dissemination S. pneumoniae pig kidney cell membrane and expression of high and low susceptibilities of penicillin-susceptible fluidity during exposure, 2169 levels of resistance, 2238 and -resistant isolates, 898 VOL. 38, 1994 SUBJECT INDEX xxix

Staphylococcus spp. susceptibilities of 123 strains, 369 fluid, 2763 prophylactic efficacy in an experimental PD 140248 Zidovudine wound infection, 1325 susceptibilities of 123 strains, 369 dideoxynucleoside resistance Viridans streptococci susceptibility patterns emergence with prolonged mono- dextranase implications for therapy, 624 therapy, 307 enhancement of antibiotic efficacy in human immunodeficiency virus type 1 re- experimental endocarditis, 953 Yersinia enterocolitica sistance platelet microbicidal protein susceptibility testing susceptibilities of variants to inhibition in vitro resistance correlates with endo- pathogenic strains isolated in Canada by acyclic nucleoside phosphonates, carditis source, 729 from 1972 to 1990, 2121 1683 Yersinia pestis murine leukemia virus impact of dosing schedule, 628 Xanthomonas maltophilia amoxicillin peripheral blood mononuclear cells ,-lactamases treatment of murine infection, 481 comparison of rates of intracellular me- biochemical properties, 2143 cefotaxime tabolism in human and primate ,B-lactams treatment of murine infection, 481 cells, 2398 susceptibilities of 123 strains tested by ceftriaxone pharmacokinetics five methods, 2317 treatment of murine infection, 481 effect of dipyridamole in asymptomatic ciprofloxacin doxycycline human immunodeficiency virus- susceptibilities of 123 strains, 369 treatment of murine infection, 481 infected subjects, 1036 susceptibilities of 123 strains tested by gentamicin radioimmunoassays five methods, 2317 treatment of murine infection, 481 evidence of alkaline phosphatase inter- clinafloxacin ofloxacin ference, 2689 susceptibilities of 123 strains, 369 treatment of murine infection, 481 toxicity quantitative relationships between expo- ofloxacin sure and efficacy, 1726 susceptibilities of 123 strains, 369 Zalcitabine Zidovudine triphosphate PD 131628 radioimmunoassay enzymatic assay susceptibilities of 123 strains, 369 determination of levels in human measurement in peripheral blood PD 138312 plasma, urine, and cerebrospinal mononuclear cells, 115